Hub : Genes

TMPRSS9

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	NTR	Blood	0.0357	0.0111	7.0e-06	0.022	0.008	0.029	0.026	0.035	7.9e-08	0.00083	8.3e-10	8.6e-09	1.3e-11
2	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0510	0.0270	2.8e-03	0.044	0.060	0.038	NA	0.040	1.6e-03	0.00023	3.2e-03	NA	2.4e-03
3	TCGA	Liver Hepatocellular Carcinoma	0.3000	0.1040	4.2e-05	0.087	0.075	0.027	NA	0.059	6.5e-05	0.00021	2.0e-02	NA	9.2e-04
4	TCGA	Stomach Adenocarcinoma	0.0830	0.0520	7.1e-03	0.016	0.007	0.006	NA	0.007	2.2e-02	0.09700	1.0e-01	NA	9.7e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.2	0.3	0.5	0.4	-0.7	-0.1	-0.7
Bipolar Disorder or Schizophrenia	0.1	0.3	0.7	-0.6	0.0	-0.3	-0.8
Depressed Affect (Nagel 2018)	0.4	0.8	2.4	-0.1	0.7	-0.2	-1.6
Depression (Nagel 2018)	0.4	0.6	2.2	-1.5	0.5	0.0	-0.4
Intelligence (Savage-Jansen 2018)	0.4	1.3	2.7	0.6	1.1	-1.6	-1.0
Neuroticism (Nagel 2018)	0.4	1.0	3.7	0.4	1.9	-0.5	-0.1
Schizophrenia (2018)	0.2	0.5	1.1	-1.1	0.5	-0.3	-0.6
Schizophrenia vs Biploar Disorder	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Worry (Nagel 2018)	0.3	0.6	1.3	-0.1	1.1	1.0	-0.0
Alzheimer’s Disease (in mother)	2.2	2.6	5.6	0.3	-2.0	0.8	-2.4
Alzheimer’s Disease (in father)	0.0	0.0	0.1	-0.1	-0.4	-0.2	0.0
Alzheimer’s Disease (including proxy)	1.4	2.0	4.6	0.1	-2.1	0.4	-1.8
Crohns Disease (2017)	0.7	1.6	2.0	1.4	1.1	-1.2	1.4
Irritable Bowel Disease (IBD)	0.1	0.2	0.6	0.4	-0.1	-0.8	0.5
Ulcerative Colitis (UC)	0.1	0.2	0.4	-0.6	-0.5	-0.1	0.0
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Reaction Time	0.2	0.4	0.9	-0.7	-1.0	-0.1	-0.4
Verbal and Numeric Reasoning (VNR)	0.5	1.1	2.6	-1.6	0.4	1.1	-0.7
Breast Cancer	0.2	0.5	1.6	1.3	-0.1	0.3	-0.6
Ovarian Cancer	0.2	0.3	0.7	-0.3	-0.8	-0.6	0.1
Prostate Cancer	0.1	0.2	0.5	0.3	-0.5	0.1	-0.7
Age at First Birth	0.3	0.4	0.7	-0.5	-0.6	0.8	-0.6
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.3	0.4	0.8	-0.2	0.9	-0.8	0.6
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.4	0.6	1.1	0.5	1.1	-1.0	0.0
Mean Putamen Volume	0.3	0.3	1.1	-0.2	0.3	0.2	1.0
Fasting Glucose	0.2	0.2	0.3	-0.6	0.3	0.4	-0.4
HbA1C	0.7	0.8	2.6	0.1	0.2	0.7	1.6
HDL Cholesterol	0.6	1.0	1.3	1.1	0.5	-1.1	1.1
LDL Cholesterol	0.3	0.5	1.1	0.1	-0.5	1.0	-0.9
Lupus	0.3	0.5	0.8	-0.9	0.9	0.6	0.3
Neuroticism (2016)	0.4	0.6	1.1	1.0	1.0	-0.4	0.3
Primary Biliary Cirrhosis	0.1	0.1	0.3	-0.2	-0.6	-0.0	-0.0
Rheumatoid Arthritis	0.5	0.8	1.7	1.3	0.5	-1.0	0.2
Schizophrenia (2014)	0.2	0.4	1.3	-1.1	0.5	-0.3	0.3
Triglycerides	0.7	1.1	2.8	-0.8	1.7	0.4	1.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ulcerative Colitis	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Blood Eosinophil Count	0.3	2.1	5.2	-0.5	-2.3	0.3	-1.7
Blood Platelet Count	0.1	1.5	4.1	0.0	-2.0	0.1	-1.4
Blood Red Count	1.2	11.2	35.6	-6.0	-1.4	2.7	0.1
Blood White Count	0.0	0.3	0.5	0.5	-0.6	0.7	-0.4
Heel T-Score	0.5	4.1	13.2	3.6	-0.2	-1.1	1.5
BMI	0.1	0.6	1.6	0.6	1.3	-0.5	0.2
Height	0.5	10.2	38.3	-6.2	-0.9	1.2	-0.3
Waist Hip Ratio (WHR)	0.5	2.5	4.9	2.0	-0.3	0.9	2.2
Systolic Blood Pressure	0.4	2.2	5.5	-0.3	-1.2	2.4	1.4
Smoking Status	0.3	0.8	1.2	-0.7	0.6	1.0	-1.1
Allergy or Eczema	0.1	0.2	0.4	-0.2	0.7	-0.6	-0.0
Cardiovascular Disease	0.2	0.5	0.9	0.9	-0.4	0.8	0.5
Hypothyroidism (self reported)	0.3	0.6	1.8	0.0	-0.7	1.4	-0.2
Respiratory disease	0.6	1.2	3.4	-1.0	-1.9	0.1	-0.7
Type 2 Diabetes (T2D) (2018)	0.9	1.7	3.0	1.4	0.6	-1.2	1.7
Lung FEV1/FVC ratio	0.5	2.4	7.8	2.8	0.4	-0.8	-1.0
Lung FVC	0.1	0.6	1.5	0.9	-0.2	-0.0	-1.2
Neuroticism	0.5	1.1	3.3	1.0	1.8	-0.2	-0.2
Chronotype (morning person)	1.2	2.8	7.8	-2.8	-1.2	-0.6	-1.2
Hair Pigment	0.1	2.4	3.3	1.6	0.6	-1.7	1.8
Tanning	0.1	0.9	1.7	-0.8	-0.8	0.7	-1.3
Hand grip strength (left)	0.9	2.5	6.9	-2.6	-0.8	0.2	-1.6
Number of treatments/medications taken	0.5	0.9	2.3	0.6	0.2	0.9	1.5
Average weekly spirits intake	0.4	0.6	2.0	-0.0	-1.4	0.1	0.4
Sensitivity / hurt feelings	0.4	0.7	1.6	-0.1	1.3	-0.6	0.8
Frequency of depressed mood in last 2 weeks	0.5	0.8	2.0	0.3	1.4	-0.8	0.5
Hearing difficulty/problems: Yes	3.8	5.9	11.0	-1.4	-3.3	2.8	-1.6
Relative age of first facial hair	0.8	1.7	3.1	0.5	-1.8	1.3	-1.3
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.3	-0.3	-0.0	0.5	1.1
Ever used hormone-replacement therapy (HRT)	1.2	1.5	2.3	1.1	1.5	-0.5	1.5
Ever had hysterectomy (womb removed)	0.4	0.4	0.8	0.9	-0.6	0.3	0.6
Systolic blood pressure, automated reading	0.1	0.3	0.8	-0.2	-0.0	0.7	0.9
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	1.3	-1.1	0.0	0.3	0.8
Angina	0.5	0.6	2.1	-0.0	-0.4	1.4	-0.6
Medication for hormone replacement therapy	0.7	0.8	1.8	0.1	1.4	1.1	0.2
Vitamin and mineral supplements	0.1	0.1	0.1	0.3	-0.1	-0.3	0.3
Supplements: Zinc	0.7	0.7	2.2	0.7	0.1	-1.5	-0.5
Medication: Co-codamol	1.4	1.6	4.5	-0.9	-1.1	2.1	-0.2
Medication: Metformin	1.0	1.5	3.1	0.8	0.7	-1.3	1.8
Diabetes (father)	0.7	0.9	1.5	0.4	1.1	-0.9	1.2
Diabetes (mother)	0.5	0.6	1.6	0.4	1.3	-0.6	-0.4
Severe depression (siblings)	0.5	0.5	2.2	-1.5	0.0	-0.1	0.1
Pack years adult smoking proportion	0.5	0.8	1.7	-0.0	-0.1	1.2	1.3
Impedance of leg (right)	0.2	1.1	1.3	1.1	-1.1	-1.0	-1.1
Leg fat-free mass (left)	1.2	6.5	19.8	-4.5	0.3	2.2	1.1
Trunk fat percentage	0.0	0.1	0.1	0.1	0.1	0.3	0.4
Hand grip strength (right)	0.8	2.2	7.5	-2.7	-0.2	0.6	-1.0
Townsend deprivation index at recruitment	0.7	1.0	1.6	1.2	-1.3	0.7	-0.7
Current tobacco smoking	0.2	0.4	0.6	-0.6	0.2	0.8	-0.7
Average weekly fortified wine intake	0.2	0.2	0.4	-0.4	-0.7	0.1	-0.3
Maternal smoking around birth	0.6	0.8	1.5	0.7	1.1	-1.2	-0.3
Fed-up feelings	0.4	0.8	1.9	0.8	0.5	-0.6	-1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.1	2.5	-1.6	0.7	0.9	-0.7
Relative age voice broke	0.5	0.8	2.0	0.3	-0.8	1.4	-0.6
Taking other prescription medications	0.8	1.3	4.4	0.1	0.9	-0.2	2.1
Age when periods started (menarche)	0.2	0.5	0.7	0.8	0.7	-0.5	-0.7
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	0.7	-0.4	-0.6	0.8	-0.0
Heel bone mineral density (BMD) T-score, automated (left)	0.0	0.1	0.1	0.4	0.4	-0.3	0.2
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	2.3	-1.5	0.3	1.4	0.6
Qualifications: CSEs or equivalent	0.2	0.2	0.4	0.6	0.6	0.2	0.4
Serious illness, injury or assault to yourself	0.5	0.6	1.8	-0.1	-0.8	-0.3	1.3
High blood pressure	0.5	1.4	3.3	1.8	-0.4	-0.1	1.4
Hayfever, allergic rhinitis or eczema	0.4	0.8	1.3	0.8	1.1	-0.9	0.7
Multivitamins +/- minerals	0.4	0.5	0.8	-0.9	-0.7	0.4	-0.8
Stomach or abdominal pain in last month	1.3	1.7	3.5	1.9	1.1	0.4	-1.4
Supplements: Glucosamine	1.4	1.8	2.9	1.7	1.3	-1.4	0.8
Diverticular disease/diverticulitis (self-reported)	0.1	0.2	0.4	0.6	-0.0	0.3	0.5
Medication: Atenolol	0.6	0.8	2.2	1.5	-0.1	-0.9	0.2
Medication: Levothyroxine sodium	0.6	1.0	1.7	-0.9	-0.5	1.3	-1.0
Sitting height	0.7	5.2	20.0	-4.5	0.1	0.6	-0.5
Chronic bronchitis/emphysema (father)	0.3	0.4	1.1	-0.6	0.0	1.1	-0.1
High blood pressure (mother)	0.2	0.3	1.0	0.4	-0.3	0.1	-1.0
Body mass index (BMI)	0.1	0.6	1.2	-0.3	0.8	0.7	1.1
Impedance of leg (left)	0.4	1.9	2.5	1.4	-1.0	-1.6	-1.4
Leg predicted mass (left)	1.2	6.3	19.4	-4.4	0.4	2.1	1.1
Trunk fat mass	0.1	0.6	1.6	-1.3	0.5	0.5	0.7
Waist circumference	0.2	0.9	1.8	-0.7	0.6	0.9	1.3
Number of incorrect matches in round	0.1	0.2	0.3	-0.5	0.1	-0.3	0.5
Past tobacco smoking	0.4	0.8	1.8	-0.7	-1.4	0.0	0.9
Alcohol usually taken with meals	1.0	1.6	3.2	0.7	0.9	-1.8	1.4
Nervous feelings	0.4	0.8	2.5	0.4	1.6	-0.1	0.7
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.7	1.7	0.5	0.8	-0.5	-1.3
Hearing difficulty/problems with background noise	1.7	2.7	3.8	-1.9	-1.7	1.9	-0.7
Hair/balding pattern: Pattern 2	0.6	0.7	2.3	-0.0	-0.0	0.8	-1.5
Had menopause	1.1	1.3	2.3	1.5	0.6	-1.2	1.0
Had other major operations	0.4	0.5	1.5	0.3	-1.2	0.1	0.4
Forced vital capacity (FVC)	0.8	3.2	9.4	-3.1	-0.3	0.8	-1.7
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.8	0.9	0.1	-0.4	0.6
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	2.1	-0.2	0.7	0.3	1.4
Qualifications: None of the above	0.4	0.9	1.9	-0.1	-1.0	1.4	-0.9
Financial difficulties in last 2 years	3.0	4.1	9.4	-3.1	0.3	2.6	-0.2
Mouth/teeth dental problems	0.3	0.4	0.9	0.7	0.3	-0.5	1.0
Heart attack	2.1	2.6	3.9	2.0	-1.6	0.7	-1.9
Allergy	0.6	1.4	3.0	-0.8	-1.0	1.7	-1.0
Pain all over the body in last month	1.5	1.6	2.9	0.3	1.2	-1.7	1.4
Diabetes (self-reported)	0.9	1.4	2.2	1.4	0.1	-1.5	1.2
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	0.9	1.0	0.4	0.9	0.3
Medication: Ramipril	0.3	0.4	0.6	0.8	-0.4	-0.7	0.6
Medication: Simvastatin	0.1	0.1	0.2	0.5	0.0	-0.3	0.5
Fluid intelligence score	0.4	0.9	2.7	-0.7	-0.4	0.4	-1.6
Illnesses of siblings	0.6	0.9	2.1	-1.4	-1.0	0.3	0.6
Neuroticism score	0.6	1.3	4.8	-0.0	2.2	0.5	0.5
Weight	0.6	2.8	8.9	-3.0	0.3	1.3	0.7
Impedance of arm (right)	0.2	0.9	1.8	1.3	-0.4	-1.2	0.0
Arm fat percentage (right)	0.1	0.4	1.3	0.4	0.6	0.0	1.1
Trunk fat-free mass	1.2	7.1	24.6	-5.0	0.2	1.8	0.7
Hip circumference	0.4	1.8	6.5	-2.5	0.3	0.8	0.2
Time employed in main current job	2.2	2.6	4.0	-0.2	-1.8	1.8	-2.0
Alcohol intake versus 10 years previously	0.8	1.2	2.8	-0.7	-1.7	-0.2	-1.2
Father’s age at death	1.0	1.3	3.5	0.6	-0.8	-1.9	-0.7
Worrier / anxious feelings	0.2	0.3	0.7	0.0	0.5	0.9	-0.4
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.7	0.5	-0.3	0.9	-0.4
Falls in the last year	1.4	1.9	3.0	1.5	1.3	-1.7	1.0
Hair/balding pattern: Pattern 3	0.1	0.2	0.4	-0.7	0.2	0.3	-0.4
Number of live births	1.5	2.1	4.4	-0.9	-1.8	2.1	-0.1
Forced expiratory volume in 1-second (FEV1)	0.9	2.9	8.0	-2.8	-0.5	1.0	-1.5
Pulse rate	2.0	3.3	6.9	-1.6	-2.6	1.9	-0.6
Happiness	3.1	3.8	6.5	-2.5	-2.2	1.9	-0.3
Noisy workplace	1.4	1.8	2.8	-1.7	-1.1	1.2	-1.3
Qualifications: A levels/AS levels or equivalent	0.6	1.3	1.7	-1.3	1.0	1.1	1.0
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.1	3.9	0.1	2.0	-0.4	0.4
Mouth/teeth dental problems: Dentures	1.6	2.7	7.5	0.1	-1.5	1.1	-2.7
Asthma	0.3	0.6	2.0	-0.0	-1.4	0.1	0.5
Medication: Ibuprofen (e.g. Nurofen)	1.2	1.6	4.1	-2.0	-0.5	1.3	-0.3
Medication: Cholesterol lowering	0.6	0.9	1.4	0.8	1.2	-0.3	1.1
Depression (self-reported)	1.6	1.9	4.7	-0.0	1.6	-0.3	2.2
Medication: Lansoprazole	0.3	0.4	0.9	-0.1	-0.2	-0.8	-0.9
Prospective memory result	2.1	2.6	4.9	-1.8	1.5	-0.4	2.2
Lung cancer (father)	0.9	1.0	2.5	1.0	0.6	-1.6	-0.3
Illnesses of mother	0.8	1.0	1.7	-1.2	-0.8	0.2	1.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	2.8	6.0	-2.5	-0.8	1.6	-1.3
Pulse wave Arterial Stiffness index	1.9	2.2	7.3	-2.7	1.1	0.1	0.5
Impedance of arm (left)	0.2	0.8	1.6	1.1	-0.5	-1.3	-0.3
Arm fat mass (right)	0.2	0.7	1.0	-1.0	0.6	0.7	0.9
Trunk predicted mass	1.2	6.7	23.5	-4.8	0.3	1.7	0.7
Standing height	1.1	11.0	41.0	-6.4	-0.8	1.5	-0.5
Length of working week for main job	0.3	0.3	0.7	0.4	0.8	0.4	-0.5
Exposure to tobacco smoke at home	1.5	1.7	3.2	-1.8	-0.8	1.6	-0.6
Breastfed as a baby	1.3	1.6	3.5	-0.1	-0.8	-1.5	-1.9
Tense / ‘highly strung’	0.1	0.2	0.8	-0.0	0.3	0.9	0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	0.7	0.7	0.6	-0.4	0.9
Hair/balding pattern: Pattern 4	0.8	2.0	3.4	-0.5	1.3	-1.6	1.8
Birth weight of first child	0.2	0.3	0.7	0.7	-0.8	0.3	0.3
Peak expiratory flow (PEF)	1.3	3.1	8.0	-2.8	-1.4	1.5	-0.2
Pulse wave reflection index	0.5	0.7	1.1	-0.6	1.1	-0.9	0.7
Ever highly irritable/argumentative for 2 days	0.5	0.6	2.1	1.5	-0.6	-0.3	0.2
Loud music exposure frequency	0.5	0.6	1.2	-0.3	-1.1	-0.2	-0.9
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	3.1	-1.8	-0.5	0.9	0.3
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.6	-1.3	-0.0	0.2	0.6
Blood clot in the leg (DVT)	0.2	0.2	0.4	0.0	-0.3	-0.6	-0.6
Medication: Paracetamol	2.2	3.7	10.2	-0.6	-1.7	3.2	-1.2
Headache pain in last month	0.5	0.9	1.9	0.5	-0.6	1.0	-1.4
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	1.5	-0.7	-0.2	-0.3	-1.2
Glaucoma (self-reported)	2.3	2.7	3.5	1.9	1.7	-1.8	1.2
Gout (self-reported)	0.4	0.5	1.1	0.8	0.6	-0.1	1.1
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.6	-0.1	0.2	0.8	0.4
Medication: Amlodipine	0.2	0.3	0.5	0.2	0.5	0.6	0.7
Medication: Ventolin 100micrograms inhaler	2.1	2.7	4.1	-2.0	-1.7	2.0	0.1
Birth weight	0.2	0.5	1.5	0.8	0.0	0.1	-1.2
Chronic bronchitis/emphysema (mother)	0.3	0.4	1.0	-1.0	0.3	-0.2	0.6
High blood pressure (siblings)	0.2	0.3	0.7	0.8	0.8	-0.1	-0.3
Forced vital capacity (FVC), Best measure	0.8	3.0	8.2	-2.9	-0.4	1.1	-1.5
Body fat percentage	0.0	0.1	0.4	0.3	0.2	0.0	0.6
Leg fat percentage (right)	0.1	0.2	0.5	0.4	0.2	-0.1	0.7
Arm fat-free mass (right)	1.0	5.4	18.7	-4.3	0.3	1.5	0.6
Exposure to tobacco smoke outside home	0.3	0.4	0.9	-0.8	0.3	1.0	-0.2
Comparative body size at age 10	0.8	2.3	4.3	2.1	1.0	-0.9	1.7
Number of full brothers	1.0	1.3	4.5	0.4	-2.1	0.3	-0.6
Worry too long after embarrassment	1.4	2.3	6.7	-0.1	2.6	0.7	1.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.7	-0.3	0.1	-0.9	0.3
Wheeze or whistling in the chest in last year	0.2	0.4	0.6	-0.5	0.8	0.2	0.7
Number of children fathered	1.9	2.1	6.2	-1.3	-0.6	0.6	-2.5
Reason for reducing amount of alcohol drunk: Health precaution	2.1	2.4	6.2	2.5	-0.1	-1.8	-0.4
Age at first live birth	0.2	0.3	0.7	-0.8	-0.1	-0.3	-0.6
Pulse wave peak to peak time	1.6	1.9	6.3	2.5	-0.9	-0.2	-0.6
Health satisfaction	1.1	1.4	2.8	-1.5	-0.2	1.7	0.8
Shortness of breath walking on level ground	0.4	0.5	0.9	0.6	0.7	-1.0	0.3
Qualifications: College or University degree	0.4	1.1	2.9	-0.7	1.0	-0.4	1.7
Eye problems/disorders: None of the above	0.3	0.3	0.7	-0.9	-0.3	0.5	-0.4
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.1	0.6	0.8	-1.0	0.2
Emphysema/chronic bronchitis	0.2	0.2	0.7	-0.8	0.1	-0.3	0.2
Medication for pain relief, constipation, heartburn	0.3	0.5	0.7	-0.8	0.6	-0.7	0.6
Neck or shoulder pain in last month	0.4	0.5	1.1	1.0	0.1	0.2	-0.9
Medication: Blood pressure	0.5	0.9	1.6	1.1	-0.7	0.3	1.2
Angina (self-reported)	0.5	0.7	2.1	-0.1	-0.4	1.4	-0.6
Migraine (self-reported)	0.6	0.7	1.8	1.4	0.0	-0.7	0.7
Medication: Ibuprofen	1.0	1.2	3.6	-1.9	-0.1	1.2	0.1
Medication: Allopurinol	0.2	0.3	0.4	0.6	0.6	-0.5	0.6
Medication: Omeprazole	0.1	0.2	0.5	0.7	0.0	0.3	-0.3
Medication: Seretide 50 evohaler	0.8	0.9	2.5	1.6	0.7	-0.6	0.5
Mean time to correctly identify matches	0.2	0.4	1.4	0.2	-1.2	-0.1	-0.5
Heart disease (mother)	0.9	1.0	3.6	1.9	0.6	-0.2	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	0.7	-0.8	-0.2	0.0	0.7
Whole body fat mass	0.2	0.8	1.8	-1.3	0.5	0.7	0.9
Leg fat mass (right)	0.2	0.9	1.8	-1.4	0.6	0.6	1.0
Arm predicted mass (right)	1.1	5.4	18.3	-4.3	0.3	1.8	0.4
Pulse rate, automated reading	0.7	2.4	5.4	-1.6	-2.3	1.3	0.3
Alcohol intake frequency.	0.7	1.5	3.1	-1.0	-1.4	1.8	0.5
Comparative height size at age 10	2.1	11.4	37.8	-6.1	-1.2	2.5	0.4
Number of full sisters	1.1	1.3	2.6	1.2	1.0	-0.3	1.6
Suffer from ‘nerves’	0.9	1.4	3.8	-0.5	1.9	0.5	1.2
Overall health rating	0.0	0.1	0.2	0.1	0.5	0.4	-0.0
Chest pain or discomfort	1.4	2.0	5.6	2.4	1.1	-0.7	0.9
Had major operations	1.2	1.4	2.9	-0.8	-1.7	0.6	1.3
Age at last live birth	0.6	0.9	1.4	-1.2	-1.2	0.5	-0.7
Family relationship satisfaction	1.2	1.4	3.7	-1.9	-0.5	1.3	-0.4
Leg pain on walking	0.8	1.0	1.8	-0.9	1.3	-0.8	1.0
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.3	-0.2	-1.1	0.7	-0.2
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.3	-0.1	0.6	-0.3	1.2
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.5	1.2	-0.8	-0.3	-0.4
Medication: Aspirin	0.7	1.0	2.7	1.6	-0.2	-1.1	-0.3
Supplements: Vitamin C	0.6	0.8	1.9	0.4	-0.6	0.8	-1.4
Knee pain experienced in last month	0.1	0.2	0.3	-0.2	-0.6	0.4	-0.2
Hypertension (Self-reported)	0.6	1.7	3.4	1.8	0.4	-0.9	1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	2.1	0.3	-1.5	0.4	-0.7
Illnesses of father: Heart disease	0.6	0.8	1.7	-1.2	-0.4	1.3	0.0
Illnesses of siblings: Diabetes	0.6	0.7	1.8	1.4	0.8	-0.5	-0.2
Smoking status: Previous	0.5	0.8	2.0	1.4	0.8	-0.5	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	2.1	4.4	15.2	-3.9	-0.4	1.5	-0.3
Whole body fat-free mass	1.2	6.9	22.9	-4.8	0.2	2.0	0.8
Leg fat-free mass (right)	1.1	5.9	18.7	-4.3	0.4	1.9	0.9
Arm fat percentage (left)	0.1	0.5	1.4	0.2	0.7	-0.0	1.2
Average weekly red wine intake	0.7	1.1	2.5	-0.7	1.1	-0.4	1.6
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.6	-1.3	0.8	-0.2	0.3
Mood swings	0.3	0.5	0.9	-0.8	0.9	0.2	-0.6
Loneliness, isolation	0.3	0.4	0.9	0.7	-0.4	0.9	-0.4
Long-standing illness, disability or infirmity	0.3	0.4	1.3	-1.1	0.3	0.3	0.3
Ever had bowel cancer screening	0.8	0.9	1.8	0.5	1.1	-1.3	-0.7
Diabetes diagnosed by doctor	0.6	1.0	1.5	1.1	0.5	-1.2	1.0
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	0.8	-0.4	-0.8	0.1	-0.9
Friendships satisfaction	1.4	1.8	5.0	-0.3	-2.2	0.4	-1.3
Qualifications: nursing, teaching	0.4	0.6	1.0	-0.7	0.7	0.6	1.0
Commuting to job workplace: Walk	1.0	1.1	3.0	-0.6	-0.7	0.8	-1.7
Eye problems/disorders: Cataract	1.3	1.5	1.9	1.3	1.4	-1.4	0.8
Mouth/teeth dental problems: Mouth ulcers	1.0	1.6	4.3	0.5	1.2	-0.7	2.1
Medication for cholesterol	0.6	0.9	2.6	-1.6	-0.6	-0.1	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	0.5	0.5	0.6	-0.2	0.7
Back pain experienced in last month	0.5	0.8	1.7	-0.7	-1.3	0.3	-0.8
Mineral and other dietary supplements	0.7	0.9	1.4	-1.1	-0.8	0.6	-1.2
Breast cancer (self-reported)	3.2	3.8	4.8	2.2	-1.8	-2.0	-1.8
Asthma (self-reported)	0.2	0.4	1.5	0.0	-1.2	0.1	0.3
Osteoporosis (self-reported)	0.7	0.8	1.6	0.3	0.5	1.2	1.3
Osteoarthritis (self-reported)	1.2	1.6	3.3	0.1	1.6	-0.8	1.8
Medication: Aspirin	0.8	1.1	2.7	1.7	-0.0	-1.3	0.1
Medication: Gliclazide	1.0	1.1	2.1	-1.5	-1.0	1.1	0.1
Illnesses of father: None of the above (group 1)	0.3	0.4	1.3	-0.3	0.0	-0.3	-1.1
Smoking status: Current	0.4	0.6	1.3	-0.9	0.0	1.2	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	1.1	-0.8	-1.0	0.8	-0.1
Whole body water mass	1.2	7.0	23.1	-4.8	0.1	2.1	0.7
Leg predicted mass (right)	1.1	5.8	18.5	-4.3	0.3	1.9	0.9
Arm fat mass (left)	0.2	0.7	1.1	-1.0	0.7	0.6	0.9
Number of self-reported non-cancer illnesses	0.7	1.2	2.3	1.5	0.7	-0.4	1.4
Average weekly champagne plus white wine intake	0.1	0.1	0.3	-0.0	-0.5	-0.5	0.3
Miserableness	0.4	0.8	2.1	-0.8	0.5	1.4	-0.1
Guilty feelings	3.2	4.7	9.0	2.1	3.0	-1.8	1.5
Wears glasses or contact lenses	1.5	1.7	4.4	2.1	1.1	-1.0	0.4
Ever taken oral contraceptive pill	0.3	0.3	0.5	-0.6	-0.7	-0.1	-0.5
Hearing aid user	0.5	0.6	1.3	-0.1	-0.5	1.1	0.8
Mother’s age at death	1.0	1.3	5.1	-2.2	0.0	-0.3	-0.3
Financial situation satisfaction	2.2	2.7	7.0	-2.6	0.9	1.4	-1.0
Tinnitus: Yes, now most or all of the time	3.9	4.6	8.7	-2.9	-2.0	1.4	-1.9
Commuting to job workplace: Public transport	0.4	0.4	0.8	-0.9	0.0	0.9	-0.0
Eye problems/disorders: Glaucoma	2.2	2.6	3.9	2.0	1.6	-1.4	1.4
Medication: Blood pressure	0.4	0.7	2.3	0.7	0.2	0.3	1.5
Pain type(s) experienced in last month: Hip pain	1.8	2.2	4.9	-1.6	0.1	2.2	1.2
Supplements: Fish oil (including cod liver oil)	0.7	0.9	1.4	1.2	1.1	-0.3	1.0
High cholesterol (Self-reported)	0.2	0.3	1.0	-0.1	0.3	1.0	0.2
Medication: Bendroflumethiazide	0.1	0.2	0.5	0.7	-0.1	0.4	0.1
Medication: Paracetamol	2.5	3.8	10.0	-0.7	-1.9	3.2	-1.0
Medication: Lisinopril	0.8	1.1	2.2	-1.5	-0.4	1.1	0.8
Medication: Atorvastatin	0.4	0.4	1.0	0.6	1.0	0.1	0.6
Illnesses of father: High blood pressure	0.6	0.8	2.7	-0.0	0.5	-0.2	1.6
Alcohol drinker status: Never	0.7	0.9	1.4	-1.0	-1.2	1.0	-0.6
Ever smoked	1.0	1.8	4.1	0.5	1.7	-0.1	-2.0
Basal metabolic rate	1.1	6.1	20.2	-4.5	0.3	1.9	0.8
Leg fat percentage (left)	0.1	0.2	0.3	0.5	0.4	-0.5	0.4
Arm fat-free mass (left)	0.9	4.7	15.5	-3.9	0.7	1.6	0.7
Number of operations (self-reported)	0.2	0.3	0.7	-0.3	-0.6	0.1	0.8
Average weekly beer plus cider intake	1.8	2.5	7.1	-1.3	0.3	1.2	-2.7
Irritability	0.4	0.7	1.6	-1.0	1.3	0.5	0.1
Risk taking	0.5	0.7	1.4	-0.2	-1.1	0.6	-1.2
Ever had prostate specific antigen (PSA) test	2.3	2.7	9.3	0.1	-0.7	1.0	-3.0
Fractured/broken bones in last 5 years	0.4	0.5	1.1	-0.7	0.0	0.6	1.1
Age started oral contraceptive pill	0.5	0.6	1.8	-0.7	0.1	-0.3	1.3
Diastolic blood pressure, automated reading	1.0	2.9	4.3	-1.8	-2.0	2.1	-0.2
Ever depressed for a whole week	0.7	0.8	1.3	1.2	0.9	-0.7	0.7
Unable to work because of sickness or disability	0.6	0.8	2.2	-0.5	-1.5	0.7	-0.5
Commuting to job workplace: Cycle	0.3	0.4	0.8	0.6	0.1	0.9	0.5
Myopia	0.6	0.9	1.9	-0.4	-1.1	0.5	-1.4
Vascular/heart problems diagnosed by doctor	0.6	1.7	5.2	-2.3	0.5	0.1	-1.2
Cholesterol lowering medication	1.0	1.4	2.2	1.1	1.5	-1.0	1.1
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	0.9	0.1	-0.4	0.9	-0.9
Pain experienced in last month	0.1	0.1	0.3	-0.5	0.1	0.1	0.3
Supplements: Calcium	0.4	0.4	1.5	1.2	-0.0	-0.1	-0.2
Basal cell carcinoma (self-reported)	0.5	0.6	1.6	0.2	-0.7	-1.2	-0.5
Heart attack/myocardial infarction (self-reported)	1.7	2.2	5.0	2.2	-1.2	0.2	-1.6
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.6	0.1	-0.2	-0.6	-0.8
Heart disease (siblings)	0.3	0.4	0.8	0.4	-0.3	0.8	0.9
Alcohol drinker status: Previous	0.2	0.2	0.6	0.1	-0.3	0.5	0.8
Pack years of smoking	0.4	0.7	1.8	0.4	0.2	0.8	1.3
Impedance of whole body	0.3	1.4	2.3	1.5	-0.6	-1.4	-0.9
Leg fat mass (left)	0.2	0.9	1.9	-1.4	0.8	0.3	1.0
Arm predicted mass (left)	1.0	4.9	16.3	-4.0	0.5	1.7	0.5