TWAS hub - AP3D1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.2700	0.0680	3.1e-04	0.118	NA	0.124	NA	0.129	4.7e-07	NA	2.6e-07	NA	1.3e-07
2	GTEx	Artery Tibial	0.1676	0.0448	4.0e-04	0.162	NA	0.152	NA	0.158	1.0e-12	NA	6.0e-12	NA	2.1e-12
3	GTEx	Brain Cerebellum	0.4610	0.1260	5.5e-04	0.035	NA	0.045	NA	-0.002	3.3e-02	NA	1.8e-02	NA	3.9e-01
4	GTEx	Cells Transformed fibroblasts	0.2210	0.0600	2.5e-04	0.010	NA	0.046	NA	0.032	5.8e-02	NA	2.2e-04	NA	2.0e-03
5	GTEx	Colon Transverse	0.3110	0.0840	8.1e-04	0.135	NA	0.130	NA	0.156	5.7e-07	NA	9.1e-07	NA	7.2e-08
6	GTEx	Esophagus Mucosa	0.1810	0.0520	1.7e-04	0.210	NA	0.202	NA	0.214	4.2e-14	NA	1.6e-13	NA	2.5e-14
7	GTEx	Esophagus Muscularis	0.3160	0.0640	2.5e-06	0.237	NA	0.228	NA	0.244	1.5e-14	NA	5.5e-14	NA	5.7e-15
8	GTEx	Lung	0.1437	0.0482	2.9e-03	0.113	NA	0.057	NA	0.121	5.5e-09	NA	3.6e-05	NA	1.6e-09
9	GTEx	Muscle Skeletal	0.1110	0.0405	6.9e-03	0.070	NA	0.047	NA	0.068	1.9e-07	NA	1.8e-05	NA	2.9e-07
10	ROSMAP	Brain Pre-frontal Cortex	0.3884	0.0368	0.0e+00	0.396	0.333	0.426	0.413	0.425	2.1e-54	4.8e-44	8.7e-60	2.2e-57	1.3e-59
11	TCGA	Bladder Urothelial Carcinoma	0.0490	0.0280	9.9e-03	0.000	0.015	0.013	NA	0.008	2.9e-01	1.7e-02	2.6e-02	NA	6.6e-02
12	TCGA	Breast Invasive Carcinoma	0.0133	0.0073	6.6e-03	0.007	0.009	0.002	NA	0.003	9.6e-03	5.4e-03	8.8e-02	NA	7.6e-02
13	TCGA	Cervical Squamous Cell Carcinoma	0.1820	0.0680	1.4e-03	0.006	0.027	0.023	NA	0.023	1.5e-01	1.8e-02	2.4e-02	NA	2.6e-02
14	TCGA	Kidney Renal Clear Cell Carcinoma	0.0365	0.0184	4.2e-03	0.040	0.028	0.035	NA	0.036	2.3e-05	3.7e-04	7.5e-05	NA	6.1e-05
15	TCGA	Lung Adenocarcinoma	0.0293	0.0153	6.5e-03	0.038	0.022	0.023	NA	0.031	2.4e-05	1.3e-03	8.8e-04	NA	1.4e-04
16	TCGA	Prostate Adenocarcinoma	0.0565	0.0235	7.2e-05	0.052	0.034	0.039	NA	0.034	3.3e-06	1.7e-04	5.7e-05	NA	1.5e-04
17	TCGA	Stomach Adenocarcinoma	0.0950	0.0330	4.7e-06	0.068	0.061	0.056	NA	0.077	1.1e-05	3.3e-05	6.2e-05	NA	3.2e-06
18	TCGA	Thyroid Carcinoma	0.0470	0.0230	5.0e-03	0.052	0.011	0.034	NA	0.039	8.2e-06	2.7e-02	2.7e-04	NA	1.0e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
Tense / ‘highly strung’	5.4	9.0	12.0	3.4	3.2	0.5	1.1	3.4	3.3	3.3	3.3	3.0	3.5	2.9	3.3	1.4	3.1	3.2	3.2	3.3	3.1
Illness, injury, bereavement, stress in last 2 years	5.3	6.4	11.3	-2.6	-2.7	-0.7	-0.6	-2.5	-2.6	-2.7	-2.9	-2.3	-2.4	-2.8	-3.4	-2.2	-2.8	-2.3	-2.9	-2.8	-2.8
Blood Red Count	5.2	50.6	130.0	7.2	6.7	2.0	1.3	7.4	7.3	7.3	6.9	5.6	7.4	9.9	11.4	4.0	6.5	7.2	8.9	7.2	6.5
Hair/balding pattern: Pattern 3	5.2	7.7	12.5	3.5	2.5	2.4	0.4	3.2	3.5	3.1	2.9	1.8	3.1	1.7	2.6	3.1	2.7	2.9	3.0	3.1	2.7
Frequency of depressed mood in last 2 weeks	4.3	6.0	9.4	2.3	2.6	2.7	1.1	2.4	2.3	2.6	2.6	3.1	2.8	2.1	1.6	1.5	2.6	2.9	2.6	2.5	2.6
Ever had stillbirth, spontaneous miscarriage or termination	4.1	4.4	6.4	2.2	2.2	1.1	0.3	2.4	2.3	2.3	2.2	1.9	2.2	1.9	2.0	2.1	2.2	2.4	2.5	2.3	2.2
Neuroticism (2016)	4.0	5.8	7.9	2.5	2.6	1.5	0.7	2.3	2.4	2.6	2.6	2.8	2.8	2.8	1.8	1.8	2.7	2.1	2.7	2.6	2.7
Impedance of arm (left)	3.8	17.7	24.9	4.9	4.6	3.0	2.7	4.4	5.0	4.6	4.7	4.0	4.8	3.4	2.6	3.7	4.4	4.2	4.5	4.7	4.4
Blood White Count	3.6	26.7	46.1	-5.3	-5.3	-2.7	-4.0	-5.0	-5.4	-5.2	-5.3	-5.2	-5.2	-5.7	-6.8	-3.7	-5.4	-5.1	-5.5	-5.5	-5.4
Pulse wave reflection index	3.6	4.5	7.4	1.7	2.2	2.4	1.9	1.8	1.5	2.1	2.2	2.6	1.8	2.7	2.6	0.7	2.3	2.4	2.0	2.1	2.3
Impedance of whole body	3.5	18.0	27.5	5.1	4.5	2.4	2.7	4.5	5.2	4.7	4.7	3.9	5.0	3.3	2.8	4.1	4.3	4.3	4.4	4.7	4.3
Hearing difficulty/problems with background noise	3.3	5.3	9.0	2.5	2.4	0.5	1.7	2.5	2.5	2.5	2.4	2.3	3.0	2.0	2.4	1.9	2.4	2.4	2.0	2.5	2.4
Comparative body size at age 10	3.3	9.2	21.5	-3.4	-3.0	-0.4	-1.1	-3.4	-3.4	-3.3	-3.1	-2.6	-3.5	-3.5	-4.6	-1.0	-3.0	-3.0	-2.8	-3.3	-3.0
Ever taken oral contraceptive pill	3.3	3.7	5.5	1.9	2.3	0.2	0.2	1.9	1.9	2.1	2.2	2.1	2.1	1.8	1.7	1.4	2.2	2.2	2.3	2.1	2.2
Irritability	3.2	5.4	9.0	2.4	2.7	0.6	0.8	2.4	2.3	2.6	2.6	2.8	2.6	2.1	1.9	0.5	2.6	3.0	2.7	2.5	2.6
Blood Platelet Count	3.1	35.6	53.3	-6.4	-6.2	-0.2	-3.9	-5.8	-6.3	-6.2	-6.4	-6.0	-5.9	-7.0	-7.3	-4.0	-6.3	-6.2	-6.7	-6.5	-6.3
Number of children fathered	3.1	3.5	5.3	1.9	1.9	1.5	0.4	2.3	2.0	2.1	2.0	1.8	1.8	1.9	1.9	1.6	1.9	1.7	2.3	2.1	1.9
Hearing aid user	3.1	3.5	5.7	-2.0	-1.9	-1.9	0.2	-2.0	-2.0	-2.0	-2.0	-2.0	-1.9	-2.4	-0.9	0.2	-2.0	-2.1	-2.4	-2.0	-2.0
Comparative height size at age 10	3.0	16.4	64.9	3.7	3.6	-0.1	-1.4	4.3	3.8	4.2	3.8	3.8	3.9	5.7	8.1	0.8	3.6	3.7	4.2	3.9	3.6
Relative age of first facial hair	2.9	5.9	11.7	-2.8	-2.1	-2.3	-0.8	-3.3	-2.9	-2.8	-2.5	-2.3	-2.7	-2.0	-3.4	-1.8	-2.1	-2.1	-2.0	-2.6	-2.1
Impedance of leg (right)	2.8	13.5	21.6	4.5	3.8	1.3	1.9	4.0	4.7	4.1	4.1	3.2	4.4	2.7	2.4	4.1	3.7	3.7	3.7	4.1	3.7
Fasting Glucose	2.7	3.3	5.4	1.5	1.9	1.9	2.2	1.5	1.4	1.8	2.0	2.3	1.8	1.5	1.8	1.1	1.9	2.0	1.9	1.8	1.9
Eye problems/disorders: Cataract	2.7	3.1	4.8	-1.4	-1.9	-2.0	-0.3	-1.8	-1.4	-1.8	-1.8	-2.2	-1.8	-1.5	-1.6	-2.1	-2.0	-1.8	-1.9	-1.8	-2.0
Impedance of arm (right)	2.6	12.1	18.7	4.2	3.6	2.5	2.4	3.6	4.3	3.8	3.9	3.3	4.1	2.5	2.0	3.4	3.5	3.5	3.6	3.8	3.5
Impedance of leg (left)	2.4	11.6	18.5	4.2	3.5	0.9	2.1	3.6	4.3	3.8	3.8	3.1	4.1	2.4	2.2	3.8	3.5	3.4	3.3	3.8	3.5
Cholesterol lowering medication	2.3	3.5	5.3	2.1	1.9	1.5	0.3	2.3	2.1	2.1	2.0	1.9	1.8	2.0	1.9	1.1	2.0	1.6	1.9	2.1	2.0
Systolic Blood Pressure	2.2	11.2	23.1	-1.9	-4.1	-1.7	-4.5	-1.6	-1.7	-3.0	-3.5	-4.8	-2.8	-4.7	-1.9	-1.8	-4.0	-4.4	-3.3	-3.1	-4.0
Happiness	2.2	2.6	4.6	-1.8	-1.8	-1.7	-2.1	-1.1	-1.7	-1.5	-1.7	-1.9	-1.5	-1.6	-1.9	-0.3	-1.8	-1.5	-0.5	-1.7	-1.8
Birth weight of first child	2.2	4.0	7.7	-2.4	-2.0	-0.7	0.3	-2.3	-2.4	-2.3	-2.2	-2.0	-1.9	-2.8	-2.1	-0.3	-2.0	-1.4	-2.4	-2.3	-2.0
Ever highly irritable/argumentative for 2 days	2.2	2.6	3.6	1.6	1.8	0.9	1.3	1.6	1.5	1.8	1.9	1.7	1.9	1.1	1.0	1.5	1.9	1.9	1.4	1.8	1.9
Forced expiratory volume in 1-second (FEV1), predicted	2.2	4.5	16.1	2.0	2.0	-0.9	-1.3	2.3	2.0	2.2	2.1	1.7	2.2	2.7	4.0	1.2	2.0	1.7	2.2	2.1	2.0
Average weekly champagne plus white wine intake	2.2	3.0	4.6	-1.8	-1.7	-0.1	-0.3	-2.0	-1.9	-2.0	-2.0	-1.6	-2.0	-1.7	-2.1	-1.1	-1.8	-1.5	-2.1	-1.9	-1.8
Medication for hormone replacement therapy	2.1	2.4	5.1	-1.7	-1.7	-0.5	0.4	-1.9	-1.7	-1.7	-1.7	-1.2	-1.5	-2.0	-2.3	-0.8	-1.5	-1.2	-1.5	-1.7	-1.5
Financial difficulties in last 2 years	2.1	2.9	6.6	1.5	1.7	0.7	0.3	1.5	1.4	1.7	1.7	1.5	1.4	2.2	2.6	1.4	1.9	1.5	2.3	1.7	1.9
Lung FEV1/FVC ratio	2.0	10.3	18.4	-3.8	-3.1	-2.8	-1.8	-4.3	-3.8	-3.6	-3.3	-2.7	-3.1	-3.0	-3.0	-3.1	-3.1	-2.8	-2.8	-3.6	-3.1
Severe depression (siblings)	2.0	2.3	4.4	2.0	1.4	0.4	0.8	1.9	2.1	1.6	1.4	1.1	1.9	1.6	1.6	0.6	1.2	1.3	2.0	1.6	1.2
Hair/balding pattern: Pattern 4	2.0	4.9	8.2	2.8	2.0	1.2	1.5	2.9	2.8	2.5	2.2	2.1	2.5	1.6	1.6	2.4	2.1	2.1	2.5	2.4	2.1
Systolic blood pressure, automated reading	1.9	5.4	11.9	-1.3	-2.8	-1.2	-3.0	-1.0	-1.1	-2.0	-2.4	-3.5	-2.0	-3.2	-1.4	-1.0	-2.8	-3.5	-2.2	-2.1	-2.8
Chronic bronchitis/emphysema (father)	1.9	2.2	3.3	1.8	1.8	0.5	1.1	1.5	1.7	1.6	1.5	1.7	1.6	0.5	1.2	1.8	1.5	1.4	1.6	1.6	1.5
Medication: Simvastatin	1.9	2.7	4.8	1.9	1.6	0.5	1.7	1.6	1.9	1.6	1.6	1.6	1.6	1.4	2.2	1.3	1.7	2.1	1.4	1.7	1.7
Illnesses of mother	1.9	2.3	5.9	1.4	1.5	2.4	1.0	1.5	1.4	1.6	1.6	1.5	1.4	1.7	0.8	1.5	1.5	1.7	1.2	1.6	1.5
Unable to work because of sickness or disability	1.9	2.4	6.7	1.5	1.5	1.4	0.5	1.9	1.5	1.8	1.6	1.5	1.7	1.5	2.6	0.5	1.5	1.4	1.5	1.6	1.5
Friendships satisfaction	1.8	2.2	8.0	-1.4	-1.6	-1.9	-2.8	-1.1	-1.3	-1.3	-1.5	-1.4	-1.0	-1.2	-1.5	-1.0	-1.6	-1.4	-0.6	-1.4	-1.6
Medication: Lisinopril	1.8	2.4	6.0	1.4	1.4	1.6	2.0	1.2	1.4	1.3	1.3	1.6	1.5	1.1	2.5	1.7	1.4	1.8	1.0	1.4	1.4
Ever had prostate specific antigen (PSA) test	1.8	2.1	4.1	-1.5	-1.3	-2.0	-1.1	-1.4	-1.5	-1.3	-1.3	-1.5	-1.5	-1.3	-1.2	-1.8	-1.4	-1.5	-1.5	-1.4	-1.4
Past tobacco smoking	1.7	3.1	5.0	-1.8	-1.8	-0.6	-1.5	-1.8	-1.8	-1.9	-1.9	-2.2	-2.0	-1.3	-1.3	-1.8	-1.9	-1.8	-1.8	-1.9	-1.9
Frequency of tiredness / lethargy in last 2 weeks	1.7	2.8	4.3	1.8	1.5	1.5	1.3	1.9	1.7	1.8	1.8	2.0	2.0	0.8	0.7	1.6	1.8	2.1	1.8	1.7	1.8
Standing height	1.7	16.4	90.1	3.4	3.2	-0.3	-0.4	3.7	3.5	3.7	3.4	3.5	3.9	6.6	9.5	0.0	3.3	3.7	3.9	3.5	3.3
Breast Cancer	1.6	3.8	10.9	-1.8	-1.9	-0.4	-2.2	-1.4	-1.8	-1.7	-1.9	-1.6	-1.8	-2.4	-3.3	-1.2	-2.0	-2.2	-1.9	-1.9	-2.0
Number of incorrect matches in round	1.6	2.6	7.3	1.7	1.4	-0.6	-0.6	2.0	1.7	1.7	1.4	1.2	1.7	2.4	2.1	0.0	1.3	1.1	2.7	1.6	1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	1.6	2.1	3.9	1.5	1.3	0.2	1.0	1.5	1.5	1.5	1.4	1.3	1.5	1.9	2.0	0.7	1.3	1.7	2.0	1.5	1.3
Qualifications: NVQ or HND or HNC or equivalent	1.6	2.0	4.1	1.5	1.2	1.1	-0.6	2.0	1.6	1.6	1.5	1.0	1.6	1.5	0.7	-1.2	1.3	1.6	1.9	1.5	1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.6	3.4	8.2	-2.1	-1.7	0.3	-0.9	-2.1	-2.1	-2.0	-2.0	-1.7	-1.7	-1.8	-2.9	-1.6	-1.9	-1.2	-1.7	-2.1	-1.9
Mother’s age at death	1.6	2.0	4.2	1.3	1.6	-0.4	0.3	1.6	1.4	1.6	1.6	1.5	1.3	2.1	1.6	0.8	1.4	1.1	1.7	1.6	1.4
Hayfever/allergic rhinitis (self-reported)	1.5	2.0	3.6	-1.3	-1.3	-1.6	-1.7	-1.3	-1.3	-1.2	-1.2	-1.8	-1.3	-1.8	-1.1	-0.7	-1.3	-1.9	-1.7	-1.3	-1.3
Emphysema/chronic bronchitis	1.5	1.6	4.1	1.4	1.0	1.5	0.5	1.3	1.4	1.2	1.2	1.1	1.2	1.1	2.0	0.5	1.1	1.8	1.2	1.3	1.1
Family relationship satisfaction	1.5	1.8	6.8	-1.2	-1.7	-0.7	-2.6	-1.1	-1.2	-1.4	-1.4	-1.5	-1.2	-0.7	-0.8	-1.0	-1.5	-1.3	-0.7	-1.4	-1.5
Vitamin and mineral supplements	1.4	1.8	3.4	1.8	1.4	-0.2	0.5	0.9	1.8	1.3	1.4	1.4	1.5	1.7	0.8	1.3	1.4	0.8	1.9	1.5	1.4
High blood pressure (mother)	1.4	2.0	4.2	-1.0	-1.6	-1.3	-2.0	-0.7	-0.9	-1.3	-1.4	-1.9	-1.2	-1.6	-1.0	-1.1	-1.6	-2.0	-1.0	-1.4	-1.6
Shortness of breath walking on level ground	1.4	1.6	3.0	1.4	1.1	0.7	-0.4	1.4	1.3	1.3	1.2	1.2	1.5	1.6	1.7	0.7	1.2	1.2	1.5	1.3	1.2
Medication: Aspirin	1.4	1.9	3.4	1.6	1.3	1.2	1.7	1.3	1.6	1.4	1.4	1.3	1.6	0.2	1.3	1.9	1.3	1.2	1.0	1.4	1.3
Height	1.3	24.4	146.4	4.0	3.9	-0.5	-0.1	4.0	4.1	4.2	4.1	4.0	4.5	8.0	12.1	0.3	3.9	4.4	5.3	4.0	3.9
Diabetes (father)	1.3	1.6	3.1	-1.1	-1.4	-0.1	-1.1	-1.4	-1.1	-1.4	-1.3	-1.7	-1.5	-1.8	-0.4	-0.4	-1.3	-1.6	-1.2	-1.3	-1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.3	2.0	5.6	1.5	1.3	-0.0	0.8	1.4	1.5	1.4	1.4	1.4	1.5	1.4	1.2	1.4	1.3	1.4	2.4	1.4	1.4
Illnesses of siblings: Diabetes	1.3	1.6	3.2	-1.5	-1.3	-0.7	-0.7	-1.4	-1.4	-1.4	-1.4	-1.5	-1.4	-1.3	-0.1	-0.7	-1.3	-1.0	-1.8	-1.4	-1.3
Mouth/teeth dental problems: Mouth ulcers	1.3	2.1	3.6	1.6	1.5	1.3	0.4	1.4	1.7	1.5	1.4	1.6	1.9	1.4	0.8	1.1	1.5	1.9	1.5	1.5	1.5
Waist Hip Ratio (WHR)	1.2	5.6	22.5	-2.4	-1.7	-1.2	0.4	-2.7	-2.6	-2.3	-2.0	-1.7	-2.2	-3.8	-4.7	0.1	-1.6	-2.4	-2.7	-2.2	-1.6
Serious illness, injury or assault to yourself	1.2	1.4	2.5	1.2	1.2	-1.0	1.6	0.8	1.1	1.1	1.3	0.8	1.0	1.1	1.5	1.2	1.3	1.2	1.2	1.2	1.3
Body mass index (BMI)	1.2	5.2	8.6	-2.6	-2.6	-1.6	-1.5	-2.2	-2.7	-2.5	-2.6	-1.8	-2.9	-2.2	-1.9	-1.1	-2.3	-2.4	-2.4	-2.5	-2.4
Had menopause	1.2	1.4	3.7	1.2	1.2	1.1	1.9	0.9	1.2	1.1	1.2	1.8	1.2	0.4	0.2	1.2	1.2	1.2	1.1	1.2	1.2
Medication: Cholesterol lowering	1.2	1.9	3.6	1.6	1.4	0.7	1.8	1.1	1.6	1.2	1.3	1.3	1.4	0.1	1.1	1.9	1.4	1.7	1.1	1.4	1.4
Blood clot in the leg (DVT)	1.2	1.6	3.5	1.4	1.3	0.1	0.8	1.4	1.4	1.4	1.4	1.9	1.3	1.2	1.1	0.6	1.4	1.1	1.3	1.4	1.4
Exposure to tobacco smoke outside home	1.2	1.6	3.4	-1.0	-1.6	-1.0	-1.2	-1.0	-1.1	-1.3	-1.5	-1.8	-1.1	-1.0	-0.6	-0.2	-1.6	-1.4	-0.7	-1.4	-1.6
Eye problems/disorders: None of the above	1.2	1.3	2.8	1.0	1.3	0.9	0.3	1.0	0.9	1.1	1.2	1.6	1.0	1.1	1.1	1.7	1.3	1.1	1.0	1.2	1.3
Neck or shoulder pain in last month	1.2	1.6	3.9	1.1	1.1	2.0	2.0	1.4	1.1	1.2	1.1	1.2	1.5	0.9	1.7	0.4	1.0	1.3	1.1	1.1	1.0
Had major operations	1.2	1.4	2.0	1.4	1.2	-1.1	0.2	1.3	1.4	1.4	1.2	1.3	1.3	1.4	1.2	0.6	1.1	1.1	1.3	1.3	1.1
Medication: Aspirin	1.2	1.5	3.7	1.5	1.1	1.5	1.3	1.2	1.6	1.2	1.2	1.1	1.4	-0.1	1.1	1.9	1.1	0.9	0.9	1.3	1.1
Basal cell carcinoma (self-reported)	1.2	1.4	3.7	-1.0	-1.2	-1.1	-0.1	-1.0	-1.0	-1.1	-1.1	-1.0	-0.8	-1.9	-1.9	1.9	-1.1	-0.6	-0.7	-1.1	-1.1
Deep venous thrombosis (DVT) (self-reported)	1.2	1.6	3.3	1.3	1.3	0.1	0.9	1.4	1.3	1.4	1.4	1.8	1.2	1.3	1.2	0.4	1.4	1.1	1.2	1.4	1.4
Depression (Nagel 2018)	1.1	1.6	2.6	1.4	1.2	1.2	-0.5	1.6	1.4	1.4	1.4	1.3	1.5	1.1	1.1	0.1	1.2	1.5	1.3	1.3	1.2
Smoking Status	1.1	2.7	5.7	1.6	1.5	0.6	1.1	1.7	1.6	1.7	1.7	1.8	1.8	2.4	1.8	0.8	1.7	1.6	2.0	1.7	1.7
Chronic bronchitis/emphysema (mother)	1.1	1.3	2.8	1.3	1.1	-1.0	1.4	1.0	1.2	1.0	1.2	1.7	1.0	0.9	0.5	0.4	1.2	1.0	1.4	1.2	1.2
Average weekly red wine intake	1.1	1.6	3.6	-1.4	-1.2	-0.7	-0.3	-1.3	-1.3	-1.3	-1.3	-1.4	-1.3	-1.9	-1.6	-0.2	-1.4	-1.0	-1.6	-1.3	-1.4
Number of operations (self-reported)	1.1	1.6	3.1	1.5	1.4	0.1	0.1	1.7	1.5	1.6	1.4	1.6	1.5	0.7	0.1	0.6	1.4	1.1	1.8	1.5	1.4
Hair/balding pattern: Pattern 2	1.0	1.2	4.0	-1.7	-0.8	-0.5	0.1	-1.5	-1.7	-1.3	-1.0	-0.3	-1.3	0.0	-0.9	-2.0	-0.8	-0.8	-1.0	-1.2	-0.8
Gout (self-reported)	1.0	1.4	5.7	-0.6	-1.0	-2.4	-1.3	-1.0	-0.5	-1.1	-1.1	-1.0	-1.2	-1.4	-0.5	-0.5	-1.1	-1.5	-1.6	-1.0	-1.1
Smoking status: Previous	1.0	1.5	2.3	1.4	1.3	0.1	1.2	1.3	1.4	1.3	1.3	1.5	1.4	0.3	0.6	1.5	1.3	1.2	1.3	1.4	1.3
Number of self-reported non-cancer illnesses	1.0	1.7	3.1	1.7	1.3	-0.8	1.1	1.8	1.7	1.6	1.4	1.0	1.4	0.4	1.2	1.3	1.2	1.1	1.3	1.5	1.2
Eye problems/disorders: Glaucoma	1.0	1.2	1.7	-1.2	-1.2	-0.6	-0.7	-1.2	-1.2	-1.1	-1.2	-1.1	-1.1	-0.8	-1.2	-1.3	-1.1	-0.8	-1.1	-1.2	-1.1
Fractured/broken bones in last 5 years	1.0	1.2	4.2	0.4	1.2	-0.9	1.8	0.4	0.4	0.8	0.9	1.3	0.4	1.8	2.0	0.5	1.1	1.4	0.5	0.9	1.1
Birth weight	0.9	1.9	3.6	-1.4	-1.2	1.4	0.2	-1.7	-1.4	-1.5	-1.4	-1.2	-1.2	-1.3	-1.4	-1.4	-1.3	-1.3	-1.9	-1.5	-1.3
Medication: Blood pressure	0.9	1.6	4.7	-0.8	-1.5	-0.5	-0.4	-0.9	-0.7	-1.2	-1.4	-1.5	-1.4	-2.2	-1.4	-0.5	-1.3	-1.6	-1.4	-1.2	-1.3
Illnesses of father: Heart disease	0.9	1.2	4.0	0.7	1.2	0.5	-0.4	1.1	0.6	1.3	1.3	1.3	0.6	0.1	1.5	2.0	1.4	1.0	0.8	1.2	1.4
Ever had bowel cancer screening	0.9	1.1	2.5	0.8	1.3	-0.0	0.2	0.7	0.8	1.2	1.2	1.6	1.2	0.8	1.1	0.0	1.3	1.3	1.0	1.2	1.3
Prostate Cancer	0.8	1.1	2.4	1.4	0.9	0.4	1.6	1.1	1.5	1.0	0.8	0.7	1.5	1.4	0.8	0.2	0.7	0.9	1.3	1.0	0.7
Heel T-Score	0.8	6.4	39.8	-1.1	-2.0	2.0	1.2	-1.6	-1.0	-1.9	-2.0	-1.5	-1.4	-5.2	-6.3	0.8	-2.0	-1.9	-2.7	-1.9	-2.0
Lung FVC	0.8	3.9	19.1	-1.9	-1.7	1.0	0.4	-2.1	-2.0	-2.0	-1.8	-1.8	-1.8	-2.2	-4.4	-2.1	-1.6	-0.6	-1.9	-1.8	-1.6
Hand grip strength (right)	0.8	2.1	9.4	1.3	0.7	-0.5	-2.4	1.7	1.4	1.2	0.9	0.5	1.2	2.5	3.1	0.3	0.8	0.2	1.7	1.1	0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.8	4.6	-0.9	-1.6	0.6	0.4	-1.2	-0.9	-1.4	-1.5	-1.1	-0.8	-2.1	-2.1	-0.5	-1.6	-1.2	-1.4	-1.4	-1.6
Mouth/teeth dental problems: Loose teeth	0.8	0.9	2.8	0.8	0.9	-0.0	0.2	0.7	0.8	1.0	0.9	1.0	0.9	1.6	1.7	0.2	1.0	1.0	0.8	1.0	1.0
Mood swings	0.8	1.5	3.4	1.2	1.3	0.5	0.9	1.3	1.2	1.3	1.3	1.4	1.5	1.1	0.6	0.3	1.3	1.8	1.3	1.2	1.3
Pain type(s) experienced in last month: Hip pain	0.8	1.0	2.7	-1.6	-0.9	0.3	-0.5	-1.3	-1.6	-1.1	-1.1	-0.8	-1.2	0.4	0.4	-0.9	-0.8	-1.2	-1.0	-1.1	-0.8
Average weekly beer plus cider intake	0.8	1.1	2.8	1.2	0.7	0.2	-0.6	1.6	1.3	1.2	1.0	0.5	0.9	1.7	1.3	0.6	0.9	0.8	1.2	1.1	0.9
Alzheimer’s Disease (in father)	0.7	0.8	2.5	-0.8	-1.0	-0.0	-0.1	-1.1	-0.8	-1.0	-0.8	-0.9	-1.0	-0.8	0.6	-0.2	-1.0	-0.9	-1.6	-0.9	-1.0
Lupus	0.7	1.1	4.0	1.5	0.2	-2.0	-0.1	1.5	1.6	0.9	0.5	-0.0	1.1	0.3	1.7	0.7	0.2	0.7	1.0	0.8	0.2
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	4.4	0.8	0.8	-1.4	2.1	1.0	0.9	1.0	0.9	0.8	0.7	-0.0	-0.1	0.2	0.8	0.6	1.0	0.9	0.8
Sitting height	0.7	5.3	39.8	1.4	1.5	0.8	0.9	1.6	1.3	1.7	1.5	2.0	1.8	4.2	6.3	-0.6	1.5	2.0	2.0	1.5	1.5
Medication: Lansoprazole	0.7	0.8	3.1	1.0	0.9	-0.1	1.3	0.7	1.0	0.8	0.7	1.1	0.8	-0.1	0.2	1.8	0.7	0.8	0.7	0.8	0.7
Pulse wave Arterial Stiffness index	0.7	0.9	3.8	0.2	0.8	0.8	1.4	0.5	0.2	0.7	0.7	1.1	0.5	1.5	1.9	0.5	0.8	1.4	0.6	0.6	0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.9	3.2	1.0	0.7	0.2	-0.0	1.2	1.1	1.0	0.8	1.0	0.7	1.2	1.8	-0.5	0.7	0.2	0.9	0.9	0.7
Handedness (chirality/laterality): Left-handed	0.7	0.8	4.1	0.5	0.5	-1.4	2.0	0.5	0.6	0.5	0.5	0.7	0.5	1.3	1.2	-0.7	0.5	0.8	1.1	0.5	0.5
Commuting to job workplace: Cycle	0.7	0.8	1.5	0.8	1.0	-0.7	1.2	0.8	0.8	0.9	0.8	0.8	0.9	0.8	0.1	1.2	0.9	1.0	0.9	0.9	0.9
Worry (Nagel 2018)	0.6	1.2	2.4	1.3	1.3	-0.0	-0.3	1.3	1.2	1.2	1.3	1.1	1.5	0.4	1.5	0.6	1.1	1.1	1.1	1.1	1.1
Alzheimer’s Disease (in mother)	0.6	0.7	1.3	-0.8	-1.0	-0.3	-0.5	-0.6	-0.7	-0.8	-1.0	-0.9	-0.5	-0.8	-0.2	-1.0	-1.1	-0.8	-0.8	-0.9	-1.1
Reaction Time	0.6	1.1	2.3	-1.0	-1.1	-1.4	-0.1	-1.1	-1.0	-1.2	-1.2	-0.9	-0.8	-0.7	0.4	-0.9	-1.1	-1.0	-1.5	-1.1	-1.1
Age when periods started (menarche)	0.6	1.5	2.6	-1.3	-1.6	0.2	0.0	-1.0	-1.3	-1.4	-1.5	-1.6	-1.0	-1.0	-1.0	-1.3	-1.4	-0.7	-1.4	-1.4	-1.4
Mouth/teeth dental problems	0.6	0.9	2.8	-1.1	-0.7	-0.5	-0.1	-1.1	-1.0	-1.0	-0.9	-0.8	-1.2	-1.0	-1.7	0.2	-0.8	-1.5	-0.1	-1.0	-0.8
Alcohol intake versus 10 years previously	0.6	0.9	2.6	0.8	1.0	0.7	0.7	0.4	0.7	0.8	0.8	1.6	1.1	1.3	0.7	0.3	1.0	1.1	1.3	0.8	1.0
Noisy workplace	0.6	0.8	3.0	0.6	0.9	1.7	1.0	0.8	0.6	0.7	0.8	1.3	0.8	0.7	0.2	-0.6	0.9	1.1	0.6	0.8	0.9
Glaucoma (self-reported)	0.6	0.7	2.2	-0.8	-0.8	-1.2	0.1	-0.9	-0.7	-0.8	-0.9	-1.0	-0.6	-0.4	-1.1	-1.5	-0.9	-0.2	-0.7	-0.9	-0.9
Pulse wave peak to peak time	0.6	0.7	2.4	-0.1	-0.7	-0.9	-1.6	-0.5	-0.1	-0.7	-0.6	-1.0	-0.4	-1.1	-1.3	-0.6	-0.7	-1.3	-0.5	-0.6	-0.7
Alcohol intake frequency.	0.6	1.5	4.0	1.3	1.0	0.3	0.8	1.4	1.3	1.4	1.2	0.9	1.3	1.6	2.0	0.5	1.2	1.1	1.4	1.2	1.2
Qualifications: nursing, teaching	0.6	0.9	1.8	1.0	1.1	0.4	1.3	1.1	0.9	1.1	1.1	1.2	0.7	0.0	-0.1	1.3	1.0	0.8	0.3	1.1	1.0
High cholesterol (Self-reported)	0.6	1.1	2.0	1.4	1.2	0.1	0.5	1.2	1.3	1.2	1.1	0.9	1.1	0.4	1.3	1.1	1.1	0.9	1.0	1.2	1.1
Illnesses of father: High blood pressure	0.6	0.7	2.2	1.4	0.5	-0.5	-0.5	1.5	1.5	1.0	0.7	0.3	1.0	-0.6	0.2	0.9	0.6	0.3	0.4	1.0	0.6
Ever smoked	0.6	1.0	2.9	1.0	1.0	0.0	1.1	0.8	1.0	0.9	1.0	1.4	1.1	0.5	0.4	1.7	1.0	0.8	1.0	1.0	1.0
Respiratory disease	0.5	1.1	2.5	0.8	0.9	1.4	-1.1	1.5	0.8	1.1	0.9	0.9	0.9	1.6	1.6	0.6	0.8	0.1	1.0	1.0	0.8
Average weekly spirits intake	0.5	0.6	2.1	0.4	0.5	1.3	-0.5	0.7	0.4	0.6	0.5	0.7	0.7	1.4	1.2	-0.7	0.5	0.7	0.6	0.5	0.5
Supplements: Zinc	0.5	0.6	7.0	-0.6	-0.4	2.6	-0.0	-0.4	-0.6	-0.3	-0.4	-0.1	-0.2	-0.4	-1.1	0.2	-0.3	-0.1	-0.6	-0.4	-0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	1.3	0.9	0.7	0.3	-0.5	1.0	0.9	0.9	0.9	0.9	0.9	1.1	0.7	-0.4	0.8	0.8	1.0	0.8	0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.0	5.6	-0.6	-1.1	1.3	0.1	-0.7	-0.5	-0.9	-1.0	-0.6	-0.5	-1.6	-2.4	-0.3	-1.0	-0.8	-0.6	-0.9	-1.0
Multivitamins +/- minerals	0.5	0.6	1.1	-0.9	-0.9	-0.0	-0.7	-0.2	-0.8	-0.7	-0.8	-0.9	-0.9	-1.1	-0.2	-0.9	-1.0	-0.5	-0.8	-0.8	-1.0
Medication: Levothyroxine sodium	0.5	0.8	4.9	1.1	0.4	0.9	0.4	1.4	1.2	0.9	0.6	0.1	0.8	-0.4	0.2	2.2	0.5	0.4	1.0	0.7	0.5
Had other major operations	0.5	0.6	1.0	0.8	0.9	0.8	-0.7	1.0	0.8	0.9	0.9	1.0	0.7	-0.3	-0.5	0.9	0.8	0.0	1.0	0.8	0.8
Medication: Ramipril	0.5	0.6	2.4	-0.4	-1.0	-1.6	-0.5	-0.5	-0.4	-0.7	-0.9	-0.9	-0.7	-0.6	-0.6	-0.6	-0.9	-0.6	-0.7	-0.7	-0.9
Number of live births	0.5	0.7	1.1	-0.8	-0.7	-0.5	-0.8	-1.0	-0.8	-0.9	-0.9	-1.0	-1.1	-0.9	-0.7	-0.8	-0.7	-0.4	-1.0	-0.8	-0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.5	4.6	-1.3	-1.1	-0.9	-1.8	-1.3	-1.3	-1.3	-1.3	-1.4	-1.0	-0.2	-0.1	-2.1	-1.2	-0.5	-0.7	-1.3	-1.2
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	2.0	-0.8	-1.0	-0.4	-0.3	-0.8	-0.7	-1.1	-0.9	-1.4	-0.8	-1.2	-0.5	-0.6	-1.0	-0.5	-1.2	-0.9	-1.0
Age at first live birth	0.5	1.0	2.6	-1.2	-0.8	-1.6	-0.4	-0.9	-1.2	-0.9	-0.9	-0.9	-1.0	-0.9	-0.9	-0.1	-0.9	-1.1	-1.1	-1.0	-0.9
Medication: Allopurinol	0.5	0.6	3.6	-0.5	-0.4	-1.9	-0.7	-0.6	-0.4	-0.6	-0.6	-0.4	-0.9	-0.6	0.1	-0.8	-0.5	-0.9	-1.3	-0.5	-0.5
Age at last live birth	0.5	0.7	3.0	-0.8	-0.8	-0.9	-1.7	-0.6	-0.7	-0.7	-0.8	-0.8	-0.8	-0.8	-0.2	0.1	-0.8	-0.8	-1.2	-0.7	-0.8
Commuting to job workplace: Walk	0.5	0.5	2.8	0.5	0.6	-1.0	0.6	0.5	0.5	0.7	0.6	0.2	0.4	0.9	0.2	0.3	0.6	0.8	1.7	0.7	0.6
Breast cancer (self-reported)	0.5	0.6	1.3	-0.8	-0.7	-0.7	-0.9	-0.9	-0.8	-0.7	-0.7	-0.5	-0.7	-1.0	-1.2	-0.9	-0.7	-0.8	-0.5	-0.8	-0.7
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.4	1.0	0.7	-0.3	0.8	1.0	1.1	0.9	0.8	0.6	0.9	0.6	0.0	-0.2	0.8	0.5	1.2	0.9	0.8
Medication: Blood pressure	0.5	0.9	3.1	1.2	0.5	-0.6	-1.0	1.5	1.2	0.9	0.6	0.4	1.0	0.2	1.6	1.7	0.5	0.3	0.8	0.8	0.5
Arm fat-free mass (left)	0.5	2.5	10.1	-1.6	-1.5	-2.1	-2.0	-1.0	-1.6	-1.3	-1.5	-0.7	-1.3	0.9	3.2	-2.0	-1.3	-0.9	-1.0	-1.4	-1.3
Arm predicted mass (left)	0.5	2.7	9.4	-1.8	-1.6	-2.0	-2.0	-1.2	-1.8	-1.4	-1.6	-0.9	-1.6	0.7	3.1	-1.8	-1.4	-1.0	-1.2	-1.5	-1.4
Neuroticism (Nagel 2018)	0.4	1.0	2.3	0.8	1.1	0.3	0.8	0.8	0.8	1.0	1.1	1.5	1.2	1.0	1.5	0.0	1.0	1.3	0.9	0.9	1.0
Schizophrenia (2018)	0.4	0.8	5.2	-0.5	0.0	0.0	-0.9	-0.2	-0.3	-0.9	-1.0	0.0	0.0	-2.3	0.1	0.7	-1.3	-1.3	-0.9	-0.9	-1.3
Neuroticism	0.4	0.9	2.5	0.6	1.0	0.1	1.1	0.6	0.5	0.8	1.0	1.6	1.0	1.1	1.1	-0.5	1.0	1.5	0.9	0.8	1.0
Hand grip strength (left)	0.4	1.1	6.0	0.9	0.3	-0.0	-1.7	1.3	1.0	0.7	0.4	0.3	0.6	1.8	2.5	-0.2	0.4	0.1	1.2	0.7	0.4
Medication: Metformin	0.4	0.6	1.1	-0.9	-1.1	0.7	-0.2	-0.9	-0.9	-0.9	-0.9	-0.5	-0.6	-0.9	-0.8	0.0	-0.8	-0.4	-0.5	-0.9	-0.8
Maternal smoking around birth	0.4	0.6	1.8	0.7	0.5	1.1	-0.5	0.9	0.7	0.7	0.7	0.5	0.7	0.4	0.5	0.7	0.7	1.1	1.3	0.7	0.7
Illnesses of siblings	0.4	0.5	1.2	-0.5	-0.5	0.8	-0.9	-0.9	-0.6	-0.8	-0.5	-0.4	-0.7	-0.4	-0.4	-0.9	-0.6	-1.1	-0.8	-0.7	-0.6
Neuroticism score	0.4	0.8	1.9	0.4	0.9	-0.7	0.8	0.4	0.3	0.7	0.9	1.4	0.9	1.1	1.2	-0.7	1.0	1.3	0.7	0.7	1.0
Trunk fat-free mass	0.4	2.5	14.4	-1.3	-1.2	-1.8	-2.3	-0.8	-1.3	-1.0	-1.3	-0.7	-1.0	1.6	3.8	-2.2	-1.1	-0.8	-0.6	-1.1	-1.1
Father’s age at death	0.4	0.5	1.0	1.0	0.7	-0.7	-0.6	1.0	1.0	0.8	0.7	0.4	0.8	0.1	0.4	0.8	0.6	0.2	0.6	0.8	0.6
Mouth/teeth dental problems: Dentures	0.4	0.6	1.1	1.0	0.5	0.4	0.9	0.9	1.0	0.9	0.9	0.6	0.8	0.6	0.7	-0.4	0.8	1.0	0.0	0.9	0.8
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	2.8	-0.3	0.5	-0.3	0.9	-0.4	-0.5	0.1	0.3	0.9	-0.0	1.7	0.5	-1.4	0.6	0.3	0.5	0.1	0.6
Lung cancer (father)	0.4	0.5	1.2	1.0	0.4	0.7	0.3	1.0	1.1	0.7	0.5	0.2	1.1	0.1	0.6	0.9	0.3	0.8	1.0	0.6	0.3
Arm fat mass (right)	0.4	1.5	3.0	-1.4	-1.5	-1.3	-1.0	-1.0	-1.4	-1.3	-1.5	-0.8	-1.7	-0.9	-0.1	-0.3	-1.3	-1.3	-1.0	-1.4	-1.3
Trunk predicted mass	0.4	2.6	13.8	-1.4	-1.3	-1.8	-2.4	-0.8	-1.4	-1.1	-1.3	-0.8	-1.1	1.4	3.7	-2.3	-1.2	-0.8	-0.7	-1.2	-1.2
Hypothyroidism/myxoedema (self-reported)	0.4	0.7	2.4	1.1	0.4	-0.8	0.8	1.3	1.2	0.8	0.6	0.1	0.8	-0.5	0.1	1.6	0.4	0.4	1.1	0.7	0.4
Medication: Amlodipine	0.4	0.6	4.1	-0.2	-0.5	-0.0	-1.2	-0.1	-0.2	-0.5	-0.5	-0.8	-0.6	-2.0	-0.6	0.6	-0.5	-0.8	-0.7	-0.5	-0.5
Medication: Ventolin 100micrograms inhaler	0.4	0.5	2.6	0.6	0.5	-0.0	-0.9	0.7	0.6	0.6	0.5	0.2	0.6	1.1	1.6	0.6	0.5	-0.0	0.7	0.6	0.5
Arm fat-free mass (right)	0.4	2.1	12.5	-1.3	-1.1	-1.9	-2.0	-0.8	-1.3	-0.9	-1.1	-0.4	-1.1	1.5	3.5	-1.8	-0.9	-0.6	-0.6	-1.0	-0.9
Health satisfaction	0.4	0.5	4.6	0.6	0.4	-0.8	0.2	0.5	0.5	0.5	0.5	0.4	0.6	-0.0	0.4	2.1	0.5	0.3	1.3	0.5	0.5
Arm predicted mass (right)	0.4	2.2	10.8	-1.5	-1.2	-1.8	-1.8	-1.0	-1.5	-1.1	-1.3	-0.6	-1.3	1.3	3.3	-2.0	-1.0	-0.7	-0.8	-1.2	-1.0
Supplements: Vitamin C	0.4	0.5	4.5	-1.0	-0.1	2.1	-1.3	-0.4	-1.1	-0.3	-0.1	-0.1	-0.4	-0.6	-0.5	-0.2	-0.1	-0.1	-0.5	-0.4	-0.1
Whole body fat-free mass	0.4	2.6	12.2	-1.5	-1.3	-1.8	-2.1	-1.0	-1.6	-1.2	-1.4	-0.7	-1.2	1.4	3.5	-2.3	-1.2	-0.8	-0.8	-1.3	-1.2
Leg fat-free mass (right)	0.4	2.2	8.9	-1.6	-1.2	-1.5	-1.7	-1.0	-1.7	-1.2	-1.3	-0.5	-1.4	1.2	3.0	-2.3	-1.0	-0.8	-0.9	-1.3	-1.0
Diabetes diagnosed by doctor	0.4	0.7	3.2	0.7	0.6	1.6	0.1	0.7	0.7	0.7	0.7	0.7	0.8	-0.2	0.3	1.8	0.7	0.8	0.8	0.7	0.7
Whole body water mass	0.4	2.5	12.1	-1.5	-1.3	-1.8	-2.1	-1.0	-1.6	-1.2	-1.4	-0.7	-1.3	1.4	3.5	-2.3	-1.2	-0.8	-0.8	-1.3	-1.2
Leg predicted mass (right)	0.4	2.3	8.4	-1.7	-1.2	-1.5	-1.7	-1.1	-1.8	-1.3	-1.4	-0.5	-1.4	1.1	2.9	-2.4	-1.1	-0.8	-1.0	-1.3	-1.1
Wears glasses or contact lenses	0.4	0.5	2.1	-0.5	-0.5	-0.3	0.1	-0.6	-0.5	-0.5	-0.5	-0.5	-0.3	-1.0	-1.5	-1.4	-0.5	-0.3	-0.5	-0.6	-0.5
Medication: Bendroflumethiazide	0.4	0.6	2.0	1.1	0.6	-0.2	0.1	1.0	1.2	0.8	0.6	0.3	0.9	0.1	0.6	1.4	0.5	0.7	0.3	0.8	0.5
Basal metabolic rate	0.4	2.0	11.5	-1.3	-1.1	-1.7	-1.9	-0.7	-1.3	-1.0	-1.2	-0.4	-1.1	1.4	3.4	-1.9	-1.0	-0.6	-0.6	-1.1	-1.0
Alcohol drinker status: Previous	0.4	0.5	1.1	1.0	0.5	-0.9	0.9	0.7	1.1	0.7	0.6	0.4	0.9	0.4	0.9	0.1	0.5	0.7	0.6	0.7	0.5
Crohns Disease (2017)	0.3	0.6	2.1	0.6	1.0	0.7	-0.0	0.6	0.6	0.8	0.9	1.4	0.7	-0.0	-0.6	-0.5	0.9	0.6	-0.1	0.8	0.9
Mean Putamen Volume	0.3	0.3	1.7	-0.7	-0.2	0.0	1.3	-0.8	-0.7	-0.6	-0.4	0.2	-0.6	0.5	-0.5	-0.4	-0.2	-0.2	-0.3	-0.5	-0.2
BMI	0.3	1.7	4.2	-1.8	-1.3	-0.8	-1.3	-1.1	-1.9	-1.4	-1.4	-0.5	-2.0	-1.3	-0.7	0.1	-1.2	-1.1	-1.3	-1.4	-1.2
Chronotype (morning person)	0.3	0.7	2.6	-1.1	-0.8	-1.5	0.9	-0.5	-1.1	-0.7	-0.7	-0.4	-0.9	0.5	1.6	-0.8	-0.7	0.1	-0.3	-0.7	-0.7
Hearing difficulty/problems: Yes	0.3	0.4	1.4	0.1	0.8	0.2	0.1	0.3	0.1	0.6	0.7	0.5	0.7	1.0	1.2	0.1	0.9	0.4	0.3	0.5	0.9
Diabetes (mother)	0.3	0.4	2.3	0.2	0.7	-0.3	0.5	0.3	0.2	0.5	0.6	0.7	0.6	0.4	1.5	0.5	0.7	0.8	0.8	0.5	0.7
Pack years adult smoking proportion	0.3	0.4	1.2	0.7	0.6	0.4	0.4	0.6	0.7	0.6	0.6	0.4	0.4	1.1	0.8	0.7	0.6	0.8	0.9	0.6	0.6
Leg fat-free mass (left)	0.3	1.8	9.5	-1.4	-1.0	-1.3	-1.8	-0.8	-1.4	-1.0	-1.1	-0.4	-1.2	1.3	3.1	-2.0	-0.9	-0.6	-0.7	-1.0	-0.9
Townsend deprivation index at recruitment	0.3	0.5	1.8	0.5	0.1	-0.6	1.4	0.3	0.5	0.3	0.2	0.2	0.6	1.3	1.1	0.4	0.3	0.4	1.1	0.3	0.3
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	5.3	0.1	-0.2	-2.3	-0.4	0.1	0.2	0.1	-0.1	-0.1	0.2	0.4	0.1	-0.9	-0.2	-0.1	0.3	-0.1	-0.2
Tinnitus: Yes, but not now, but have in the past	0.3	0.4	0.7	-0.5	-0.8	-0.7	-0.9	-0.5	-0.5	-0.6	-0.5	-0.8	-0.7	-0.7	-0.3	0.2	-0.6	-0.4	-0.6	-0.6	-0.6
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	1.9	-0.5	-0.5	-0.5	0.1	-0.6	-0.5	-0.5	-0.4	-0.3	-1.1	-0.8	-1.4	0.1	-0.4	-1.0	0.3	-0.4	-0.4
Leg predicted mass (left)	0.3	1.8	9.9	-1.4	-1.0	-1.3	-1.7	-0.7	-1.4	-0.9	-1.1	-0.3	-1.2	1.4	3.1	-2.0	-0.8	-0.5	-0.7	-1.0	-0.8
Waist circumference	0.3	1.1	2.9	-1.3	-1.2	-1.7	-0.8	-0.9	-1.4	-1.1	-1.2	-0.5	-1.4	-0.9	-0.2	-0.1	-1.0	-1.1	-1.1	-1.1	-1.0
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	1.2	-0.2	-0.7	-1.1	0.5	-0.4	-0.2	-0.6	-0.6	-0.5	-0.1	-0.3	-1.1	0.4	-0.6	-0.3	0.3	-0.5	-0.6
Qualifications: None of the above	0.3	0.6	1.7	0.5	0.5	1.1	1.3	0.1	0.4	0.4	0.5	0.6	0.6	1.3	0.5	0.5	0.6	0.7	1.2	0.4	0.6
Diabetes (self-reported)	0.3	0.4	2.5	0.7	0.3	0.6	0.1	0.6	0.7	0.6	0.5	0.5	0.7	-0.5	0.3	1.6	0.5	0.5	0.6	0.5	0.5
Arm fat percentage (right)	0.3	1.2	2.4	-1.0	-1.3	-0.8	-0.5	-0.7	-1.0	-1.1	-1.2	-0.7	-1.4	-1.5	-1.5	0.6	-1.1	-1.2	-0.8	-1.1	-1.1
Hip circumference	0.3	1.3	11.5	0.6	0.3	-0.8	-1.0	1.1	0.7	0.8	0.5	0.9	0.4	1.8	3.4	0.0	0.5	0.9	1.0	0.7	0.5
Forced expiratory volume in 1-second (FEV1)	0.3	0.9	5.1	-1.0	-0.8	-0.4	-1.2	-1.0	-1.0	-0.9	-0.9	-0.9	-0.7	0.3	0.6	-2.3	-0.9	-0.1	-0.6	-0.9	-0.9
Pulse rate	0.3	0.6	1.1	-0.7	-0.8	-0.3	-0.6	-0.7	-0.7	-0.7	-0.8	-1.1	-0.8	-0.8	-0.2	1.0	-0.9	-0.5	-1.0	-0.8	-0.9
Headache pain in last month	0.3	0.5	1.8	-0.9	-0.4	-0.7	-0.1	-1.0	-1.0	-0.7	-0.7	-0.1	-0.4	-1.4	-0.6	0.7	-0.4	-0.3	-0.9	-0.7	-0.4
High blood pressure (siblings)	0.3	0.4	1.3	0.7	0.4	-0.0	0.9	1.1	0.8	0.8	0.6	0.3	0.9	0.1	-0.0	1.0	0.5	0.5	0.9	0.7	0.5
Number of full brothers	0.3	0.4	3.7	0.0	0.5	-0.6	-0.2	0.4	0.0	0.4	0.4	0.3	0.4	0.1	0.6	1.9	0.5	0.5	0.9	0.3	0.5
Medication for pain relief, constipation, heartburn	0.3	0.5	2.4	-0.3	-0.8	-0.8	-1.6	-0.0	-0.2	-0.4	-0.5	-1.3	-0.4	-0.5	-0.5	-0.0	-0.8	-0.7	-0.5	-0.5	-0.8
Medication: Ibuprofen	0.3	0.4	3.0	-0.3	0.4	-0.0	0.6	-0.4	-0.5	-0.0	0.2	0.7	-0.0	1.4	0.3	-1.7	0.4	0.3	0.3	0.1	0.4
Medication: Omeprazole	0.3	0.4	1.8	-0.7	-0.2	-0.8	0.6	-0.7	-0.8	-0.4	-0.3	-0.5	-0.8	-0.5	-0.1	-1.3	-0.2	-0.2	-0.7	-0.4	-0.2
Back pain experienced in last month	0.3	0.5	2.8	0.1	0.4	0.6	0.5	0.6	0.1	0.4	0.5	0.7	0.4	1.5	1.7	-0.6	0.4	0.2	0.3	0.3	0.4
Mineral and other dietary supplements	0.3	0.4	1.5	-0.3	-0.7	-0.2	-1.0	-0.2	-0.3	-0.4	-0.6	-0.5	-0.4	-0.7	-0.1	0.8	-0.6	-1.2	-0.3	-0.5	-0.6
Osteoporosis (self-reported)	0.3	0.4	1.7	-0.5	-0.6	-0.1	-0.1	-0.3	-0.4	-0.4	-0.5	-0.6	-0.3	-1.3	-1.1	0.5	-0.6	-0.1	-0.7	-0.5	-0.6
Illnesses of father: None of the above (group 1)	0.3	0.4	2.1	-0.3	-0.3	0.3	1.1	-0.5	-0.3	-0.4	-0.4	-0.3	0.1	1.1	-0.3	-1.5	-0.5	0.2	0.0	-0.4	-0.5
Miserableness	0.3	0.6	1.8	0.2	0.8	-1.2	0.8	0.1	0.1	0.5	0.7	1.1	0.5	1.1	0.6	-0.5	0.8	1.4	0.3	0.5	0.8
Guilty feelings	0.3	0.5	1.5	-0.8	-0.3	-1.0	1.0	-1.2	-0.9	-0.7	-0.4	0.2	-0.4	-0.1	-0.5	-1.1	-0.3	-0.4	-0.5	-0.6	-0.3
Alcohol drinker status: Never	0.3	0.4	1.6	0.6	0.3	-0.0	0.5	1.0	0.6	0.7	0.5	0.1	0.6	0.4	1.3	0.7	0.4	0.5	0.7	0.5	0.4
Leg fat percentage (left)	0.3	1.0	3.1	-1.0	-1.1	-1.8	-0.2	-0.7	-1.0	-1.0	-1.1	-0.6	-1.3	-1.1	-0.9	0.7	-1.0	-0.9	-1.1	-1.0	-1.0
Age started oral contraceptive pill	0.3	0.3	1.3	0.6	0.3	1.0	1.1	0.3	0.6	0.3	0.3	0.5	0.5	0.2	-0.1	0.9	0.3	0.3	0.9	0.4	0.3
Diastolic blood pressure, automated reading	0.3	0.9	4.5	0.9	0.7	0.5	0.4	0.9	0.8	0.8	0.7	0.3	0.9	0.8	1.8	2.1	0.7	0.4	1.0	0.8	0.7
Myopia	0.3	0.4	1.5	-0.6	-0.5	-0.4	-1.2	-0.2	-0.5	-0.3	-0.4	-0.8	-0.4	-0.1	-1.1	-1.0	-0.4	-0.6	0.0	-0.4	-0.4
Pain experienced in last month	0.3	0.5	3.3	0.1	-0.1	0.5	-1.7	-0.1	0.1	-0.1	-0.0	-0.6	-0.3	-0.7	-1.8	0.6	-0.2	-0.8	0.0	-0.0	-0.2
Supplements: Calcium	0.3	0.3	1.1	0.3	0.6	1.1	0.9	0.2	0.2	0.4	0.6	0.6	0.4	-0.3	0.0	0.3	0.6	0.7	0.0	0.4	0.6
Bipolar Disorder (2018)	0.2	0.3	1.9	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.0	1.0	0.0	1.4	1.0
Alzheimer’s Disease (including proxy)	0.2	0.3	0.6	-0.5	-0.6	0.2	-0.4	-0.4	-0.4	-0.5	-0.5	-0.6	-0.4	-0.5	0.6	-0.3	-0.7	-0.5	-0.8	-0.5	-0.7
Irritable Bowel Disease (IBD)	0.2	0.5	1.5	0.8	0.8	0.5	0.1	0.8	0.8	0.8	0.8	1.2	0.8	-0.4	0.1	0.4	0.7	1.0	0.2	0.8	0.7
Verbal and Numeric Reasoning (VNR)	0.2	0.4	2.9	-0.4	-0.1	-1.7	-0.3	-0.3	-0.4	-0.2	-0.3	-0.6	-0.5	-1.0	-1.0	0.7	-0.3	-0.5	-0.5	-0.3	-0.3
HbA1C	0.2	0.2	1.0	0.1	0.2	0.1	-0.4	0.5	0.1	0.4	0.3	-0.0	0.3	-0.7	-0.5	1.0	0.3	0.5	0.1	0.2	0.3
Schizophrenia (2014)	0.2	0.5	3.5	0.0	0.0	0.0	-0.6	0.2	0.2	-0.4	-0.5	-0.8	0.0	-1.9	0.7	1.2	-0.9	-0.8	-0.6	-0.5	-0.9
Cardiovascular Disease	0.2	0.7	2.2	1.2	0.2	-0.5	-0.5	1.4	1.3	0.8	0.4	-0.0	0.9	-0.6	0.8	1.5	0.2	0.4	1.0	0.6	0.2
Hypothyroidism (self reported)	0.2	0.5	2.9	-0.0	-0.7	-1.1	0.0	0.1	0.0	-0.4	-0.6	-0.7	-0.3	-1.7	-1.1	0.3	-0.7	-0.5	-0.1	-0.5	-0.7
Type 2 Diabetes (T2D) (2018)	0.2	0.3	2.6	0.1	-0.2	1.2	0.4	-0.0	0.0	-0.1	-0.0	0.2	0.2	-1.2	-0.6	1.6	0.0	0.2	0.0	-0.1	0.0
Tanning	0.2	1.9	4.1	1.6	1.2	2.0	-0.6	1.7	1.6	1.5	1.3	0.9	1.4	1.8	0.3	-0.3	1.2	0.9	2.0	1.4	1.2
Ever used hormone-replacement therapy (HRT)	0.2	0.3	1.0	-0.4	-0.6	-0.5	0.2	-0.5	-0.4	-0.6	-0.6	-0.1	-0.5	-0.9	-1.0	0.1	-0.6	-0.5	-0.1	-0.6	-0.6
Medication: Co-codamol	0.2	0.3	1.1	0.6	0.4	1.1	0.5	0.6	0.6	0.5	0.4	0.2	0.7	0.3	0.2	0.7	0.3	0.3	0.4	0.4	0.3
Relative age voice broke	0.2	0.3	2.2	-0.4	0.0	-1.5	-0.6	-0.6	-0.5	-0.3	-0.2	-0.0	-0.3	-0.8	-1.1	0.2	0.0	-0.2	-0.6	-0.2	0.0
Taking other prescription medications	0.2	0.3	2.2	-0.4	-0.0	-1.5	1.0	-0.4	-0.4	-0.3	-0.2	0.0	-0.2	-0.1	0.6	-0.1	-0.2	0.2	-0.2	-0.3	-0.2
Hayfever, allergic rhinitis or eczema	0.2	0.3	2.7	-0.3	-0.4	-0.9	-1.6	-0.3	-0.3	-0.4	-0.3	-0.4	-0.1	-0.7	-0.4	0.2	-0.3	-0.8	-0.5	-0.3	-0.3
Supplements: Glucosamine	0.2	0.2	2.1	0.0	0.3	0.0	1.4	-0.1	-0.1	0.0	0.3	0.2	-0.0	0.8	0.2	-0.7	0.3	0.8	-0.1	0.1	0.3
Alcohol usually taken with meals	0.2	0.3	1.5	-0.4	-0.1	-1.2	0.0	-0.7	-0.4	-0.4	-0.4	-0.1	-0.6	-0.1	0.3	-0.2	-0.3	-0.9	-0.6	-0.4	-0.3
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	1.1	0.5	0.5	0.1	0.4	0.2	0.4	0.4	0.6	0.7	0.7	0.8	0.6	-0.0	0.5	1.0	0.6	0.4	0.5
Forced vital capacity (FVC)	0.2	0.7	3.3	0.5	0.3	-0.1	-0.4	0.6	0.6	0.5	0.3	0.2	0.6	1.8	1.7	-1.5	0.3	1.1	0.9	0.5	0.3
Allergy	0.2	0.5	1.3	-0.8	-0.6	0.8	1.1	-1.0	-0.8	-0.7	-0.7	-0.5	-0.9	-0.7	-1.1	-0.3	-0.6	-0.2	-0.4	-0.7	-0.6
Weight	0.2	1.1	6.2	-0.9	-0.9	-1.7	-1.5	-0.4	-0.9	-0.7	-0.9	-0.1	-1.0	0.9	2.5	-1.0	-0.7	-0.5	-0.4	-0.7	-0.7
Worrier / anxious feelings	0.2	0.5	2.3	-0.5	-0.4	-1.5	-0.4	-0.7	-0.5	-0.5	-0.5	-0.7	-0.5	-1.0	-0.3	-0.5	-0.6	-0.9	-0.3	-0.6	-0.6
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.6	0.4	0.4	-0.1	0.1	0.5	0.4	0.5	0.5	0.8	0.2	0.8	-0.0	0.0	0.6	0.6	0.5	0.5	0.6
Length of working week for main job	0.2	0.2	1.1	-0.1	-0.7	0.0	-0.5	-0.1	-0.2	-0.4	-0.6	-0.4	-0.1	-1.0	-0.2	-0.2	-0.6	-0.5	-0.1	-0.5	-0.6
Exposure to tobacco smoke at home	0.2	0.3	3.3	-0.3	-0.3	0.4	-1.8	-0.1	-0.3	-0.2	-0.3	-0.4	-0.2	0.1	-0.2	0.5	-0.3	-0.0	0.3	-0.3	-0.3
Breastfed as a baby	0.2	0.2	1.3	-0.1	-0.2	-1.0	-0.4	-0.1	-0.1	-0.2	-0.3	-0.1	-0.3	0.6	-0.1	-1.1	-0.3	-0.3	0.1	-0.3	-0.3
Worry too long after embarrassment	0.2	0.3	1.9	-0.0	0.3	-0.7	1.4	-0.3	-0.1	0.1	0.3	0.5	0.1	0.6	0.5	-0.9	0.3	0.2	-0.1	0.1	0.3
Wheeze or whistling in the chest in last year	0.2	0.3	1.4	-0.4	-0.6	1.2	-0.8	-0.4	-0.4	-0.5	-0.5	0.1	-0.1	-0.3	0.2	0.6	-0.5	-0.4	-0.1	-0.5	-0.5
Heart disease (mother)	0.2	0.3	0.7	-0.6	-0.4	-0.4	0.1	-0.8	-0.6	-0.7	-0.6	-0.5	-0.5	-0.4	-0.4	-0.4	-0.4	-0.6	-0.2	-0.6	-0.4
Leg fat mass (right)	0.2	0.7	3.5	-0.9	-1.0	-1.9	-0.7	-0.5	-0.9	-0.8	-0.9	-0.4	-1.2	-0.2	0.7	0.2	-0.8	-0.7	-0.8	-0.8	-0.8
Pulse rate, automated reading	0.2	0.5	1.4	-0.8	-0.5	-1.2	-0.4	-0.9	-0.7	-0.6	-0.6	-0.8	-0.8	-0.6	0.5	0.6	-0.6	-0.8	-0.8	-0.7	-0.6
Number of full sisters	0.2	0.2	1.0	0.2	-0.2	0.6	-1.0	0.3	0.3	0.0	-0.2	-0.8	0.2	-0.2	-0.3	-0.5	-0.2	-0.6	0.4	-0.0	-0.2
Leg pain on walking	0.2	0.2	0.9	0.4	0.4	0.1	0.2	0.4	0.3	0.5	0.5	0.5	0.3	-0.0	-0.1	-0.6	0.6	0.5	0.9	0.5	0.6
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.6	-0.4	-0.2	0.4	-0.7	-0.4	-0.4	-0.4	-0.4	-0.3	-0.4	-0.1	0.1	-0.8	-0.3	-0.5	-0.3	-0.4	-0.3
Knee pain experienced in last month	0.2	0.3	4.0	0.3	-0.1	-0.7	2.0	-0.2	0.3	-0.1	-0.2	0.3	0.4	0.4	0.7	-0.3	0.0	0.7	-0.0	-0.0	0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	1.0	0.4	0.3	-0.0	1.0	0.4	0.3	0.3	0.3	-0.1	0.3	0.1	0.5	1.0	0.2	0.5	0.2	0.3	0.2
Medication for cholesterol	0.2	0.3	2.7	-0.7	-0.1	-0.2	-0.3	-0.7	-0.7	-0.5	-0.3	-0.4	-0.5	0.4	-0.0	-1.7	-0.3	-0.5	-0.5	-0.4	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.6	0.4	0.6	0.2	0.4	0.2	0.4	0.4	0.5	0.5	0.3	0.7	0.2	-0.8	0.5	0.5	0.3	0.5	0.5
Osteoarthritis (self-reported)	0.2	0.2	1.4	0.3	0.2	-0.4	1.2	0.4	0.4	0.2	0.2	0.1	0.4	0.1	1.0	-0.4	0.1	0.4	0.4	0.2	0.1
Medication: Gliclazide	0.2	0.2	1.3	-0.2	-0.4	-0.1	-0.3	-0.4	-0.2	-0.3	-0.2	-0.3	-0.1	-1.2	-0.7	0.8	-0.3	0.1	-0.1	-0.3	-0.3
Arm fat mass (left)	0.2	1.0	2.0	-1.1	-1.2	-1.2	-1.1	-0.7	-1.1	-1.0	-1.2	-0.6	-1.4	-0.5	0.2	-0.1	-1.0	-1.1	-0.7	-1.1	-1.0
Commuting to job workplace: Public transport	0.2	0.3	2.0	-0.0	-0.6	-1.4	0.0	0.4	0.1	-0.1	-0.4	-0.8	-0.0	-0.1	0.3	-0.3	-0.6	-0.3	-0.5	-0.3	-0.6
Medication: Atorvastatin	0.2	0.2	2.1	-0.0	-0.3	1.4	-0.0	-0.1	-0.0	-0.1	-0.2	-0.6	-0.2	-0.9	-0.3	0.1	-0.2	-0.2	-0.4	-0.2	-0.2
Risk taking	0.2	0.2	1.3	0.5	0.3	0.5	-0.5	0.6	0.5	0.5	0.4	0.4	0.3	-0.1	1.1	-0.0	0.6	0.3	0.2	0.6	0.6
Ever depressed for a whole week	0.2	0.2	1.8	0.2	0.2	-1.4	-0.5	0.0	0.2	0.2	0.2	0.0	0.3	-0.1	-1.0	0.2	0.2	-0.1	0.7	0.2	0.2
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.7	-0.5	-0.2	-0.1	0.4	-0.5	-0.6	-0.3	-0.3	-0.6	-0.6	-0.7	0.0	-0.8	-0.2	0.1	-0.7	-0.3	-0.2
Heart disease (siblings)	0.2	0.2	0.9	-0.4	0.3	-0.2	0.6	-0.1	-0.4	0.2	0.2	0.3	-0.1	0.9	-0.0	-0.2	0.4	0.9	1.0	0.1	0.4
Leg fat mass (left)	0.2	0.8	3.8	-1.0	-1.0	-1.9	-0.6	-0.6	-1.0	-0.9	-1.0	-0.4	-1.2	-0.1	0.8	-0.1	-0.8	-0.6	-0.8	-0.9	-0.8
Bipolar Disorder or Schizophrenia	0.1	0.4	1.7	0.7	0.0	0.0	-1.3	1.2	0.9	0.6	0.4	0.0	0.0	-1.0	0.0	0.0	-0.0	-0.1	0.5	0.4	-0.0
Depressed Affect (Nagel 2018)	0.1	0.2	0.9	-0.1	0.1	0.1	1.0	-0.1	-0.1	0.0	0.2	0.7	0.3	0.5	0.5	-0.6	0.1	0.8	-0.1	-0.0	0.1
Intelligence (Savage-Jansen 2018)	0.1	0.3	2.7	-0.0	0.3	-1.6	-0.2	-0.1	-0.0	0.1	0.2	0.1	-0.2	-0.8	-0.6	0.9	0.1	-0.3	-0.2	0.1	0.1
Ovarian Cancer	0.1	0.2	2.6	0.1	0.1	1.6	-0.5	0.0	0.2	0.0	-0.1	0.1	0.3	-0.4	-0.4	0.1	0.0	-0.1	0.3	-0.0	0.0
Age at First Birth	0.1	0.2	0.6	-0.4	-0.3	-0.3	-0.4	-0.4	-0.5	-0.4	-0.4	-0.4	-0.3	-0.5	-0.8	-0.8	-0.4	0.1	-0.4	-0.4	-0.4
HDL Cholesterol	0.1	0.1	0.3	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	-0.3	-0.3	0.6	-0.5	-0.5	-0.4	-0.4	-0.5
Primary Biliary Cirrhosis	0.1	0.1	1.1	0.2	-0.3	-1.1	-0.2	0.1	0.2	-0.1	-0.3	-0.3	0.1	0.0	-0.2	0.0	-0.4	-0.7	0.5	-0.2	-0.4
Rheumatoid Arthritis	0.1	0.2	0.6	-0.6	-0.3	0.0	-0.3	-0.2	-0.6	-0.2	-0.1	0.1	-0.8	0.0	-0.4	-0.4	-0.2	-0.7	-0.5	-0.3	-0.2
Ulcerative Colitis	0.1	0.1	1.5	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	-0.7	0.1	1.2	0.1	-0.0	-0.0	0.2	0.1
Allergy or Eczema	0.1	0.2	0.6	0.2	0.6	-0.4	-0.8	0.1	0.2	0.3	0.4	0.5	0.3	0.2	0.1	0.5	0.4	-0.2	0.6	0.3	0.4
Number of treatments/medications taken	0.1	0.2	0.8	-0.5	-0.3	-0.3	0.2	-0.6	-0.5	-0.5	-0.5	-0.0	-0.3	-0.9	-0.2	-0.3	-0.3	-0.1	-0.5	-0.5	-0.3
Sensitivity / hurt feelings	0.1	0.2	1.1	-0.4	0.0	0.7	1.0	-0.3	-0.4	-0.1	0.1	0.4	-0.2	0.6	0.5	-0.4	0.1	0.4	-0.1	-0.1	0.1
Ever had hysterectomy (womb removed)	0.1	0.1	0.3	-0.1	-0.2	-0.6	0.3	0.2	-0.0	0.0	-0.1	0.1	0.1	0.3	0.0	-0.5	-0.2	0.5	0.1	-0.1	-0.2
Eye problems/disorders: Diabetes related eye disease	0.1	0.2	1.3	0.0	0.1	-0.1	1.2	-0.2	0.0	-0.1	0.1	0.1	0.2	0.6	0.9	-0.1	0.1	0.3	0.1	0.0	0.1
Angina	0.1	0.1	0.4	0.2	0.5	0.3	0.2	0.0	0.2	0.4	0.4	0.4	0.1	-0.3	0.6	0.6	0.6	0.0	0.3	0.4	0.6
Current tobacco smoking	0.1	0.1	1.4	-0.2	-0.1	-0.3	0.3	-0.1	-0.2	-0.1	0.0	0.2	-0.2	1.2	0.2	-0.0	0.1	-0.0	0.4	-0.0	0.1
Average weekly fortified wine intake	0.1	0.1	0.4	0.3	0.1	0.0	-0.0	0.4	0.3	0.2	0.2	0.1	0.2	0.4	-0.3	0.7	0.1	0.0	0.0	0.2	0.1
Fed-up feelings	0.1	0.3	1.5	-0.1	0.3	0.1	1.0	-0.1	-0.2	0.1	0.4	1.2	0.2	0.6	-0.2	-0.7	0.4	0.6	0.0	0.1	0.4
High blood pressure	0.1	0.3	1.3	0.8	-0.4	-0.3	-0.7	0.9	0.9	0.2	-0.1	-0.7	0.4	-1.1	0.3	0.6	-0.3	-0.6	0.2	0.1	-0.3
Stomach or abdominal pain in last month	0.1	0.2	0.4	0.1	0.4	0.3	0.6	0.4	0.0	0.5	0.5	0.6	0.2	0.4	-0.1	-0.4	0.6	0.5	0.3	0.4	0.6
Medication: Atenolol	0.1	0.2	0.7	0.5	-0.5	-0.7	-0.7	0.2	0.5	-0.1	-0.3	-0.1	0.2	-0.8	0.1	-0.7	-0.4	-0.3	-0.2	-0.1	-0.4
Trunk fat mass	0.1	0.3	1.3	-0.4	-0.5	-1.0	-0.7	0.1	-0.4	-0.3	-0.4	0.1	-0.6	0.3	1.2	0.2	-0.4	-0.2	-0.2	-0.3	-0.4
Nervous feelings	0.1	0.2	2.2	-0.2	-0.1	-1.5	-0.5	-0.1	-0.2	-0.2	-0.1	-0.2	-0.0	-0.7	0.6	-0.0	-0.2	-0.3	-0.4	-0.3	-0.2
Heart attack	0.1	0.2	1.1	-0.3	0.1	0.7	0.9	-0.2	-0.4	-0.0	-0.0	0.1	-0.3	-1.0	-0.3	0.4	0.2	-0.0	-0.5	-0.1	0.2
Pain all over the body in last month	0.1	0.1	0.6	-0.3	-0.3	0.2	0.8	-0.2	-0.3	-0.3	-0.3	0.0	-0.3	-0.4	0.4	-0.5	-0.2	0.4	-0.5	-0.3	-0.2
Fluid intelligence score	0.1	0.3	1.6	-0.2	-0.2	-0.8	0.0	-0.0	-0.1	-0.1	-0.4	-0.6	-0.3	-0.5	-1.3	1.2	-0.4	-0.6	0.2	-0.2	-0.4
Time employed in main current job	0.1	0.1	0.8	-0.4	0.1	0.2	0.5	-0.4	-0.4	-0.2	-0.1	0.3	-0.4	0.1	-0.9	0.7	-0.0	-0.3	-0.2	-0.2	-0.0
Falls in the last year	0.1	0.2	1.0	0.4	0.4	0.0	-0.1	0.2	0.3	0.4	0.3	0.6	0.4	0.5	1.0	-0.5	0.4	0.6	0.1	0.4	0.4
Qualifications: A levels/AS levels or equivalent	0.1	0.3	1.2	0.5	0.5	-0.3	0.9	0.6	0.6	0.5	0.4	-0.2	0.5	-0.4	1.1	0.6	0.3	0.3	-0.4	0.5	0.3
Asthma	0.1	0.2	2.0	0.2	0.1	0.3	-1.4	0.7	0.2	0.3	0.1	-0.1	0.2	0.3	0.7	0.8	-0.0	-0.6	0.1	0.2	-0.0
Depression (self-reported)	0.1	0.1	0.5	0.1	0.0	-0.7	0.5	-0.1	0.1	-0.0	0.0	-0.0	0.1	0.5	0.3	-0.3	-0.1	0.1	-0.2	-0.0	-0.1
Prospective memory result	0.1	0.1	0.8	-0.3	0.1	0.5	-0.9	-0.2	-0.3	0.0	0.2	0.4	-0.2	-0.5	0.3	0.4	0.2	0.3	-0.3	0.1	0.2
Peak expiratory flow (PEF)	0.1	0.3	0.9	-0.0	0.6	-0.4	-0.1	-0.1	0.0	0.3	0.4	0.6	0.2	0.9	0.9	-0.8	0.5	0.6	0.6	0.4	0.5
Loud music exposure frequency	0.1	0.1	1.1	-0.1	-0.3	1.1	-0.1	-0.0	-0.2	-0.2	-0.2	-0.1	0.1	0.1	-0.8	0.3	-0.2	-0.3	-0.2	-0.2	-0.2
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.5	-0.4	-0.3	0.3	-0.5	-0.1	-0.3	-0.1	-0.3	-0.1	-0.1	0.0	0.6	-0.6	-0.3	0.0	-0.7	-0.2	-0.3
Medication: Paracetamol	0.1	0.2	0.7	-0.7	0.0	0.7	-0.1	-0.5	-0.8	-0.3	-0.2	0.3	-0.4	-0.5	-0.3	0.5	0.1	-0.1	-0.3	-0.3	0.1
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.9	-0.5	-0.2	-0.4	-0.8	-0.3	-0.6	-0.2	-0.2	-0.2	-0.2	0.8	0.1	-0.9	-0.3	-0.3	-0.1	-0.3	-0.3
Forced vital capacity (FVC), Best measure	0.1	0.3	1.9	-0.0	-0.2	-0.5	-1.0	0.0	0.1	-0.1	-0.3	-0.5	0.1	1.0	0.9	-1.4	-0.3	0.4	0.4	-0.2	-0.3
Leg fat percentage (right)	0.1	0.5	2.4	-0.5	-0.7	-1.5	-0.3	-0.2	-0.5	-0.5	-0.6	-0.3	-0.9	-0.8	-0.7	1.2	-0.6	-0.5	-0.6	-0.5	-0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.3	-0.1	-0.1	-0.4	0.5	-0.2	-0.0	-0.2	-0.1	-0.1	0.2	-0.5	-0.5	-0.1	-0.3	0.2	0.1	-0.2	-0.3
Qualifications: College or University degree	0.1	0.3	1.6	0.3	0.8	-1.3	1.0	-0.2	0.2	0.4	0.5	0.6	0.3	-0.3	0.5	0.1	0.7	0.3	-0.5	0.5	0.7
Angina (self-reported)	0.1	0.1	0.5	0.1	0.4	0.1	0.0	-0.0	0.1	0.3	0.3	0.4	-0.0	-0.4	0.7	0.7	0.5	-0.0	0.3	0.3	0.5
Migraine (self-reported)	0.1	0.2	1.3	0.4	0.3	0.5	-1.1	0.1	0.4	0.2	0.3	0.5	0.5	0.3	0.4	-0.3	0.2	0.1	-0.2	0.2	0.2
Medication: Seretide 50 evohaler	0.1	0.1	1.4	-0.2	-0.3	-0.3	-0.5	-0.3	-0.2	-0.3	-0.3	-0.0	-0.0	-0.2	-1.2	-0.4	-0.1	-0.5	-0.2	-0.2	-0.1
Mean time to correctly identify matches	0.1	0.1	0.9	-0.2	-0.3	-0.2	1.0	-0.3	-0.2	-0.3	-0.3	-0.2	0.0	-0.2	0.5	0.5	-0.3	0.2	-0.2	-0.3	-0.3
Whole body fat mass	0.1	0.4	1.7	-0.6	-0.7	-1.3	-0.7	-0.2	-0.6	-0.5	-0.6	-0.1	-0.9	0.2	1.0	0.1	-0.5	-0.4	-0.5	-0.5	-0.5
Suffer from ‘nerves’	0.1	0.1	0.6	-0.2	-0.1	-0.2	-0.7	-0.1	-0.2	-0.2	-0.1	0.1	-0.2	-0.0	0.1	-0.8	-0.1	-0.2	-0.4	-0.2	-0.1
Overall health rating	0.1	0.2	1.3	-0.5	-0.4	0.3	1.1	-0.1	-0.6	-0.2	-0.2	0.1	-0.4	0.1	0.7	-0.0	-0.2	0.0	0.5	-0.3	-0.2
Chest pain or discomfort	0.1	0.1	0.4	-0.5	0.1	0.0	-0.3	-0.5	-0.6	-0.2	0.0	0.4	-0.2	0.2	0.0	-0.6	0.1	-0.4	-0.1	-0.2	0.1
Hypertension (Self-reported)	0.1	0.4	1.4	1.1	-0.2	-0.2	-0.3	1.2	1.2	0.5	0.1	-0.4	0.7	-0.8	0.7	0.9	-0.1	-0.3	0.4	0.4	-0.1
Arm fat percentage (left)	0.1	0.5	1.2	-0.7	-0.8	-0.6	-0.2	-0.3	-0.6	-0.7	-0.7	-0.3	-1.1	-1.0	-1.1	0.7	-0.7	-0.8	-0.4	-0.7	-0.7
Long-standing illness, disability or infirmity	0.1	0.1	0.6	0.2	-0.2	0.6	0.6	0.4	0.2	0.1	-0.1	-0.0	0.1	0.3	-0.2	0.5	-0.2	-0.2	0.8	-0.0	-0.2
Asthma (self-reported)	0.1	0.3	2.0	0.2	-0.0	0.4	-1.4	0.8	0.2	0.2	0.1	-0.2	0.2	0.4	0.8	0.7	-0.1	-0.6	0.2	0.2	-0.1
Smoking status: Current	0.1	0.1	1.3	-0.4	-0.2	-0.2	0.4	-0.3	-0.4	-0.3	-0.1	0.0	-0.3	1.1	0.1	-0.0	-0.0	-0.1	0.3	-0.2	-0.0
Financial situation satisfaction	0.1	0.1	0.5	-0.1	-0.1	-0.7	-0.7	-0.2	-0.1	-0.2	-0.1	-0.0	0.0	0.4	0.3	0.5	-0.1	-0.2	0.4	-0.2	-0.1
Supplements: Fish oil (including cod liver oil)	0.1	0.2	0.5	-0.5	-0.2	0.0	0.1	-0.6	-0.6	-0.5	-0.5	-0.3	-0.4	0.1	-0.4	-0.7	-0.4	0.2	-0.3	-0.4	-0.4
Medication: Paracetamol	0.1	0.2	1.0	-0.7	-0.1	1.0	-0.4	-0.5	-0.8	-0.3	-0.3	0.1	-0.4	-0.3	-0.6	-0.1	-0.1	0.1	-0.4	-0.4	-0.1
Vascular/heart problems diagnosed by doctor	0.1	0.3	1.3	-1.1	0.0	-0.3	-0.1	-1.0	-1.1	-0.5	-0.2	0.3	-0.6	0.7	-0.5	-0.8	-0.0	0.3	-0.4	-0.4	-0.0
Heart attack/myocardial infarction (self-reported)	0.1	0.2	1.2	-0.4	0.1	0.7	1.1	-0.3	-0.4	-0.1	-0.0	0.2	-0.3	-0.9	-0.2	0.3	0.2	-0.0	-0.4	-0.1	0.2
Pack years of smoking	0.1	0.2	0.6	0.4	0.3	0.5	0.4	0.3	0.4	0.3	0.4	0.2	0.2	0.8	0.5	0.3	0.4	0.6	0.5	0.4	0.4
Schizophrenia vs Biploar Disorder	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ulcerative Colitis (UC)	0.0	0.1	0.6	0.0	-0.3	-0.4	-0.4	0.1	0.1	-0.1	-0.2	-0.0	-0.0	-0.8	-0.1	0.3	-0.3	0.5	-0.1	-0.1	-0.3
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
LDL Cholesterol	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Triglycerides	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Blood Eosinophil Count	0.0	0.3	3.2	0.2	0.3	1.8	-0.7	0.6	0.2	0.6	0.3	0.4	0.5	-0.2	-0.5	-0.2	0.3	0.7	0.0	0.2	0.3
Hair Pigment	0.0	1.0	2.5	-1.5	-0.5	-0.3	0.1	-1.2	-1.5	-0.9	-0.9	-0.3	-1.2	-0.8	-1.0	-1.6	-0.7	-0.3	-1.3	-1.0	-0.7
Trunk fat percentage	0.0	0.1	1.3	0.1	-0.0	-0.4	0.0	0.4	0.2	0.2	0.1	0.4	-0.2	-0.1	0.3	1.1	0.1	0.2	0.0	0.2	0.1
Qualifications: CSEs or equivalent	0.0	0.1	0.2	-0.3	0.2	-0.1	0.2	-0.3	-0.4	-0.1	0.1	0.1	-0.2	0.1	-0.2	-0.4	0.2	0.2	0.2	0.0	0.2
Body fat percentage	0.0	0.1	1.5	-0.1	-0.2	-0.7	-0.0	0.2	-0.1	-0.0	-0.1	0.3	-0.4	-0.3	-0.0	1.2	-0.1	-0.1	-0.2	-0.0	-0.1
Loneliness, isolation	0.0	0.1	0.4	-0.2	-0.0	0.1	0.6	0.1	-0.1	0.1	0.1	0.4	0.1	-0.4	-0.4	0.1	0.1	0.1	0.4	-0.0	0.1

Hub : Genes

AP3D1

Models

Trait associations