Best TWAS P=4.7e-15 · Best GWAS P=7.31e-15 conditioned to 1.93e-08
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Esophagus Muscularis | ZNF414 | 0.18 | 0.09 | lasso | 3 | 0.07 | 3.2e-05 | -5.7 | -6.3 | 3.1e-10 | 0.01 | 0.07 | 0.92 | FALSE |
| 2 | GTEx | Nerve Tibial | ZNF414 | 0.18 | 0.08 | lasso | 6 | 0.09 | 5.3e-07 | -5.6 | -5.8 | 8.7e-09 | 0.00 | 0.89 | 0.10 | FALSE |
| 3 | ROSMAP | Brain Pre-frontal Cortex | ZNF414 | 0.07 | 0.07 | lasso | 4 | 0.06 | 2.7e-08 | -5.7 | -5.7 | 1.3e-08 | 0.00 | 0.89 | 0.11 | FALSE |
| 4 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | PRAM1 | 0.04 | 0.00 | blup | 44 | 0.00 | 8.7e-02 | -5.7 | -5.2 | 2.0e-07 | 0.01 | 0.01 | 0.30 | FALSE |
| 5 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | ZNF414 | 0.09 | 0.14 | lasso | 4 | 0.13 | 9.6e-08 | -5.7 | -5.8 | 6.3e-09 | 0.01 | 0.77 | 0.22 | FALSE |
| 6 | The Cancer Genome Atlas | Brain Lower Grade Glioma | MYO1F | 0.05 | 0.01 | blup | 42 | 0.03 | 2.2e-04 | -7.1 | -7.8 | 4.7e-15 | 0.31 | 0.00 | 0.94 | TRUE |
| 7 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | MYO1F | 0.04 | 0.00 | blup | 42 | 0.02 | 1.4e-03 | -7.1 | -5.3 | 1.0e-07 | 0.13 | 0.00 | 0.85 | FALSE |
| 8 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ZNF414 | 0.04 | 0.01 | blup | 39 | 0.02 | 1.9e-03 | -5.8 | -6.4 | 1.5e-10 | 0.05 | 0.18 | 0.50 | FALSE |
| 9 | The Cancer Genome Atlas | Stomach Adenocarcinoma | PRAM1 | 0.05 | 0.02 | blup | 44 | 0.01 | 3.4e-02 | -5.5 | -5.9 | 4.5e-09 | 0.04 | 0.01 | 0.74 | FALSE |