Best TWAS P=1.43e-19 · Best GWAS P=8.59e-14 conditioned to 0.00324
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | S1PR2 | 0.07 | 0.02 | bslmm | 369 | 0.03 | 5.3e-05 | -3.9 | 5.1 | 3.0e-07 | 0.01 | 0.32 | 0.14 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | ZNF788 | 0.08 | 0.05 | lasso | 6 | 0.04 | 5.9e-06 | 5.8 | 5.5 | 3.2e-08 | 0.06 | 0.01 | 0.99 | TRUE |
| 3 | GTEx | Adipose Subcutaneous | ILF3-AS1 | 0.18 | 0.05 | enet | 27 | 0.12 | 1.2e-09 | -5.1 | -8.2 | 2.0e-16 | 0.09 | 0.14 | 0.73 | FALSE |
| 4 | GTEx | Artery Aorta | ILF3-AS1 | 0.13 | 0.05 | lasso | 6 | 0.06 | 4.5e-04 | -6.0 | -6.9 | 5.9e-12 | -0.05 | 0.36 | 0.30 | FALSE |
| 5 | GTEx | Colon Transverse | ILF3-AS1 | 0.17 | 0.11 | lasso | 4 | 0.10 | 2.1e-05 | -5.1 | -6.1 | 1.4e-09 | -0.07 | 0.20 | 0.14 | FALSE |
| 6 | GTEx | Esophagus Mucosa | SLC44A2 | 0.13 | 0.00 | lasso | 6 | 0.02 | 1.4e-02 | 3.6 | -5.4 | 8.5e-08 | -0.01 | 0.06 | 0.66 | FALSE |
| 7 | GTEx | Esophagus Mucosa | ILF3-AS1 | 0.11 | 0.00 | lasso | 4 | 0.00 | 2.5e-01 | 7.0 | -9.0 | 1.4e-19 | 0.01 | 0.02 | 0.89 | TRUE |
| 8 | GTEx | Heart Left Ventricle | ILF3-AS1 | 0.16 | 0.06 | lasso | 9 | 0.04 | 3.1e-03 | -6.0 | -7.3 | 3.1e-13 | -0.04 | 0.13 | 0.08 | FALSE |
| 9 | GTEx | Lung | ILF3-AS1 | 0.11 | 0.10 | lasso | 4 | 0.09 | 1.8e-07 | -6.0 | -7.2 | 7.2e-13 | -0.03 | 0.68 | 0.28 | FALSE |
| 10 | GTEx | Muscle Skeletal | SLC44A2 | 0.19 | 0.18 | lasso | 5 | 0.19 | 5.1e-18 | 6.5 | 6.9 | 4.3e-12 | 0.01 | 0.10 | 0.90 | FALSE |
| 11 | GTEx | Nerve Tibial | ILF3-AS1 | 0.14 | 0.04 | lasso | 3 | 0.08 | 3.8e-06 | 6.8 | -8.6 | 8.6e-18 | 0.02 | 0.01 | 0.98 | FALSE |
| 12 | GTEx | Skin Sun Exposed Lower leg | ILF3-AS1 | 0.14 | 0.08 | enet | 14 | 0.06 | 5.9e-06 | -6.0 | -6.2 | 5.8e-10 | -0.03 | 0.74 | 0.24 | FALSE |
| 13 | ROSMAP | Brain Pre-frontal Cortex | ILF3-AS1 | 0.15 | 0.04 | bslmm | 354 | 0.18 | 7.1e-22 | -5.1 | -8.3 | 8.6e-17 | -0.02 | 0.04 | 0.96 | FALSE |
| 14 | The Cancer Genome Atlas | Breast Invasive Carcinoma | S1PR2 | 0.02 | 0.00 | blup | 32 | 0.01 | 1.5e-02 | -4.2 | 5.3 | 1.5e-07 | -0.06 | 0.01 | 0.03 | TRUE |
| 15 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | LOC147727 | 0.13 | 0.02 | blup | 28 | 0.04 | 7.2e-05 | 6.8 | -8.5 | 1.2e-17 | 0.03 | 0.01 | 0.88 | FALSE |
| 16 | The Cancer Genome Atlas | Brain Lower Grade Glioma | KANK2 | 0.28 | 0.26 | lasso | 3 | 0.26 | 4.6e-29 | -7.1 | -7.0 | 2.3e-12 | 0.82 | 0.02 | 0.98 | TRUE |
| 17 | The Cancer Genome Atlas | Brain Lower Grade Glioma | LOC147727 | 0.07 | 0.02 | lasso | 2 | 0.02 | 5.4e-03 | 7.0 | -7.3 | 2.9e-13 | 0.04 | 0.01 | 0.87 | FALSE |
| 18 | The Cancer Genome Atlas | Prostate Adenocarcinoma | KANK2 | 0.09 | 0.04 | blup | 76 | 0.06 | 9.5e-07 | -7.0 | -5.6 | 2.5e-08 | 0.64 | 0.01 | 0.98 | FALSE |
| 19 | The Cancer Genome Atlas | Thyroid Carcinoma | LOC147727 | 0.24 | 0.02 | enet | 18 | 0.07 | 6.1e-07 | 6.4 | -7.4 | 1.0e-13 | -0.06 | 0.01 | 0.30 | FALSE |