Best TWAS P=2.61e-20 · Best GWAS P=4.39e-17 conditioned to 0.000144
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | METTL8 | 0.07 | 0.05 | lasso | 4 | 0.06 | 1.0e-07 | 5.2 | -5.7 | 9.2e-09 | 0.03 | 0.99 | 0.00 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | CYBRD1 | 0.33 | 0.10 | lasso | 10 | 0.26 | 4.6e-14 | -2.7 | 5.3 | 1.1e-07 | -0.04 | 1.00 | 0.00 | FALSE |
| 3 | GTEx | Artery Coronary | CYBRD1 | 0.29 | 0.01 | enet | 44 | 0.11 | 2.0e-04 | -2.7 | 9.2 | 2.6e-20 | -0.57 | 0.05 | 0.57 | TRUE |
| 4 | GTEx | Esophagus Muscularis | CYBRD1 | 0.33 | 0.07 | lasso | 9 | 0.22 | 1.3e-13 | -3.2 | 5.7 | 1.5e-08 | -0.06 | 1.00 | 0.00 | FALSE |
| 5 | GTEx | Lung | CYBRD1 | 0.14 | 0.05 | enet | 8 | 0.10 | 5.6e-08 | 3.2 | 5.2 | 1.7e-07 | -0.07 | 0.99 | 0.00 | FALSE |
| 6 | GTEx | Spleen | METTL8 | 0.39 | 0.34 | lasso | 2 | 0.29 | 4.4e-08 | 6.2 | -6.1 | 8.7e-10 | -0.01 | 0.88 | 0.01 | FALSE |
| 7 | GTEx | Testis | GORASP2 | 0.17 | 0.12 | lasso | 3 | 0.11 | 1.5e-05 | -8.1 | 8.0 | 1.7e-15 | -0.91 | 0.07 | 0.92 | FALSE |
| 8 | NTR | Blood | METTL8 | 0.03 | 0.02 | lasso | 7 | 0.02 | 1.7e-08 | 5.2 | -6.1 | 8.1e-10 | 0.03 | 1.00 | 0.00 | FALSE |
| 9 | YFS | Blood | METTL8 | 0.04 | 0.03 | lasso | 9 | 0.03 | 4.4e-11 | 6.2 | -6.1 | 1.2e-09 | 0.00 | 1.00 | 0.00 | FALSE |
| 10 | The Cancer Genome Atlas | Breast Invasive Carcinoma | TLK1 | 0.02 | 0.02 | blup | 95 | 0.02 | 1.3e-04 | -8.4 | 7.1 | 1.6e-12 | -0.96 | 0.02 | 0.97 | FALSE |
| 11 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | CYBRD1 | 0.14 | 0.04 | enet | 12 | 0.09 | 2.2e-05 | -5.6 | -5.3 | 1.4e-07 | 0.08 | 0.00 | 0.94 | FALSE |
| 12 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | METTL8 | 0.06 | 0.01 | enet | 15 | 0.04 | 4.4e-05 | 6.3 | -6.3 | 3.4e-10 | 0.04 | 0.00 | 0.99 | FALSE |
| 13 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | GAD1 | 0.09 | 0.04 | blup | 57 | 0.04 | 1.3e-03 | -3.0 | -5.4 | 5.3e-08 | 0.54 | 0.01 | 0.11 | FALSE |