Hub : Genes

GORASP2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Testis	0.1690	0.0550	8.9e-05	0.117	NA	0.067	NA	0.109	7.4e-06	NA	0.00066	NA	1.5e-05
2	NTR	Blood	0.0194	0.0100	1.4e-02	0.002	0.002	-0.001	0.002	0.002	5.3e-02	0.091	0.73000	0.051	7.5e-02
3	TCGA	Brain Lower Grade Glioma	0.0400	0.0263	7.5e-03	0.000	-0.002	0.004	NA	-0.002	3.5e-01	0.780	0.10000	NA	9.8e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	1.1	1.8	3.3	-0.6	1.4	1.8
Bipolar Disorder or Schizophrenia	0.2	0.4	1.2	-1.1	-0.3	0.1
Depressed Affect (Nagel 2018)	2.6	5.5	9.3	1.2	-3.0	-2.4
Depression (Nagel 2018)	1.5	2.3	3.5	-0.4	-1.8	-1.9
Intelligence (Savage-Jansen 2018)	0.3	1.0	2.3	-1.5	0.5	0.7
Neuroticism (Nagel 2018)	2.3	5.4	8.6	1.3	-2.9	-2.4
Schizophrenia (2018)	1.0	2.0	2.7	-1.0	-1.6	-1.7
Schizophrenia vs Biploar Disorder	2.3	3.0	6.5	-1.6	0.2	-2.5
Worry (Nagel 2018)	1.9	3.9	5.9	1.5	-2.4	-1.9
Alzheimer’s Disease (in mother)	0.5	0.5	0.9	-0.8	0.9	0.4
Alzheimer’s Disease (in father)	0.4	0.5	0.6	0.8	-0.6	0.6
Alzheimer’s Disease (including proxy)	0.2	0.3	0.4	-0.3	0.6	0.6
Crohns Disease (2017)	1.2	2.7	5.5	-0.9	-1.3	-2.3
Irritable Bowel Disease (IBD)	0.9	2.0	3.0	-0.2	-1.7	-1.7
Ulcerative Colitis (UC)	0.5	1.0	1.9	0.5	-1.4	-0.9
Major Depression (MDD)	2.2	2.7	4.7	0.5	-1.8	-2.2
Reaction Time	0.7	1.3	2.2	-1.5	0.8	1.0
Verbal and Numeric Reasoning (VNR)	0.5	1.3	2.4	-0.6	-1.5	-1.1
Breast Cancer	0.5	1.1	2.0	-1.4	-0.1	1.1
Ovarian Cancer	5.0	6.7	9.1	-3.0	2.7	2.0
Prostate Cancer	1.1	1.6	2.2	0.9	1.4	1.5
Age at First Birth	1.1	1.6	4.5	2.1	-0.4	-0.2
Bipolar Disorder (2011)	0.9	0.9	1.4	0.8	0.8	1.2
Body Mass Index (BMI) (2010)	1.4	1.9	3.5	-0.4	1.9	1.4
Coronary Artery Disease (CAD)	2.6	3.1	6.5	0.8	1.5	2.5
Crohns Disease (2012)	0.3	0.4	0.8	-0.1	-0.7	-0.9
Mean Putamen Volume	0.7	0.8	1.5	-0.1	-1.2	-0.9
Fasting Glucose	0.3	0.4	1.0	1.0	0.3	0.3
HbA1C	0.4	0.5	0.6	0.8	0.8	0.5
HDL Cholesterol	0.2	0.3	0.5	-0.7	-0.5	-0.1
LDL Cholesterol	0.0	0.0	0.1	0.1	-0.1	-0.3
Lupus	0.7	1.1	2.7	-0.8	1.6	-0.0
Neuroticism (2016)	0.8	1.2	2.9	0.9	-1.7	-0.1
Primary Biliary Cirrhosis	0.3	0.5	0.9	-0.9	0.2	-0.7
Rheumatoid Arthritis	0.4	0.5	1.3	-0.1	-0.5	-1.1
Schizophrenia (2014)	0.9	2.0	4.4	-1.1	-0.5	-2.1
Triglycerides	1.0	1.6	3.5	0.5	-1.0	-1.9
Type 2 Diabetes (T2D) (2012)	0.7	0.8	1.6	-1.3	0.8	-0.3
Ulcerative Colitis	0.3	0.4	0.6	0.8	-0.7	0.3
Blood Eosinophil Count	0.3	2.3	4.0	0.2	-1.7	-2.0
Blood Platelet Count	0.8	9.5	16.1	4.0	-2.1	2.8
Blood Red Count	0.4	4.0	4.7	1.7	-2.2	-2.1
Blood White Count	0.4	3.0	4.0	-1.7	1.5	2.0
Heel T-Score	0.2	1.7	2.3	-1.3	1.1	1.5
BMI	0.5	2.8	5.0	-2.2	1.7	-0.6
Height	3.3	64.5	96.4	9.8	-7.5	-6.4
Waist Hip Ratio (WHR)	0.6	2.5	7.0	-0.4	-2.6	-0.6
Systolic Blood Pressure	1.7	8.6	12.6	-3.3	3.5	1.6
Smoking Status	0.3	0.6	0.9	-0.6	0.8	-0.9
Allergy or Eczema	2.9	7.7	17.1	-4.1	2.4	0.5
Cardiovascular Disease	0.8	2.7	5.1	-2.3	1.0	-1.5
Hypothyroidism (self reported)	0.9	2.2	6.0	-0.3	-0.6	-2.5
Respiratory disease	1.0	2.2	4.5	0.5	-2.1	-1.4
Type 2 Diabetes (T2D) (2018)	1.5	2.9	6.3	-1.2	2.5	1.0
Lung FEV1/FVC ratio	1.2	6.3	15.6	-4.0	1.2	1.3
Lung FVC	0.8	3.9	11.2	3.4	-0.4	0.5
Neuroticism	1.8	4.4	7.0	1.3	-2.1	-2.6
Chronotype (morning person)	1.0	2.2	6.1	-2.5	0.8	-0.3
Hair Pigment	0.0	0.5	1.3	0.5	0.2	-1.1
Tanning	0.1	1.3	3.5	0.0	0.6	1.9
Hand grip strength (left)	4.3	11.3	16.7	4.1	-3.6	-2.1
Number of treatments/medications taken	2.7	4.9	13.4	-3.7	1.1	-0.4
Average weekly spirits intake	6.8	8.4	11.1	-3.3	2.9	2.4
Sensitivity / hurt feelings	0.6	1.1	2.4	-0.8	-0.5	-1.6
Frequency of depressed mood in last 2 weeks	0.7	1.0	1.7	-0.6	-1.0	-1.3
Hearing difficulty/problems: Yes	0.5	0.8	2.1	0.6	-1.4	-0.3
Relative age of first facial hair	1.6	3.3	5.3	-2.3	1.9	1.0
Other serious medical condition/disability diagnosed by doctor	0.4	0.6	1.3	-0.7	-0.1	-1.1
Ever used hormone-replacement therapy (HRT)	4.5	5.7	12.0	-3.5	2.2	0.6
Ever had hysterectomy (womb removed)	0.5	0.5	1.3	0.5	-1.1	-0.2
Systolic blood pressure, automated reading	4.1	12.1	20.6	-3.0	4.5	2.6
Eye problems/disorders: Diabetes related eye disease	0.8	0.8	1.8	-1.3	0.5	0.7
Angina	0.4	0.5	1.1	0.3	-0.5	-1.0
Medication for hormone replacement therapy	0.1	0.1	0.3	-0.5	0.3	-0.0
Vitamin and mineral supplements	0.8	1.1	1.9	-1.4	0.9	-0.7
Supplements: Zinc	1.3	1.4	1.6	1.2	-1.1	-1.3
Medication: Co-codamol	1.8	2.1	3.0	-1.6	1.0	1.7
Medication: Metformin	0.2	0.2	0.4	0.6	-0.2	-0.6
Diabetes (father)	0.5	0.6	1.7	-1.3	0.4	-0.1
Diabetes (mother)	0.5	0.7	1.1	-1.0	-0.1	-1.1
Severe depression (siblings)	0.8	0.9	1.0	-1.0	1.0	0.9
Pack years adult smoking proportion	0.4	0.6	1.4	-0.7	-0.1	1.2
Impedance of leg (right)	0.6	2.9	3.9	-2.0	-1.5	1.6
Leg fat-free mass (left)	2.0	10.8	20.3	4.5	-1.4	-3.2
Trunk fat percentage	0.9	3.5	6.9	-2.6	1.4	1.2
Hand grip strength (right)	3.8	10.2	13.1	3.6	-3.1	-2.8
Townsend deprivation index at recruitment	0.5	0.7	1.5	-0.8	-0.2	-1.2
Current tobacco smoking	0.8	1.3	3.2	-1.8	0.9	-0.4
Average weekly fortified wine intake	0.9	1.0	2.6	-0.5	0.5	1.6
Maternal smoking around birth	1.3	1.8	3.3	-1.8	1.3	0.7
Fed-up feelings	0.9	1.6	2.9	1.0	-1.7	-1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	1.0	2.1	-0.6	-1.5	-0.6
Relative age voice broke	1.1	1.7	2.4	-1.2	1.2	1.5
Taking other prescription medications	1.2	1.9	5.4	-2.3	0.4	-0.4
Age when periods started (menarche)	1.4	3.3	6.8	-2.6	1.3	1.2
Bilateral oophorectomy (both ovaries removed)	1.1	1.3	1.7	1.3	-1.3	-0.8
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.2	6.2	-0.2	0.5	2.5
Tinnitus: Yes, but not now, but have in the past	0.6	0.7	1.0	1.0	-0.8	-0.7
Qualifications: CSEs or equivalent	1.4	1.8	4.9	0.5	-2.2	0.4
Serious illness, injury or assault to yourself	1.3	1.6	2.9	-1.7	1.3	0.2
High blood pressure	1.4	3.9	6.6	-2.2	2.6	-0.8
Hayfever, allergic rhinitis or eczema	2.8	6.0	13.0	-3.6	2.0	0.9
Multivitamins +/- minerals	0.1	0.2	0.4	0.7	0.2	0.3
Stomach or abdominal pain in last month	0.5	0.6	1.7	-0.3	-1.3	-0.3
Supplements: Glucosamine	0.2	0.2	0.5	0.1	0.3	-0.7
Diverticular disease/diverticulitis (self-reported)	1.5	1.8	4.8	-2.2	0.7	0.3
Medication: Atenolol	0.4	0.5	1.0	-1.0	-0.8	-0.0
Medication: Levothyroxine sodium	1.7	2.8	6.2	-0.8	-1.3	-2.5
Sitting height	2.6	18.2	30.7	5.5	-3.4	-3.5
Chronic bronchitis/emphysema (father)	2.7	3.2	7.9	-2.8	1.0	0.8
High blood pressure (mother)	0.3	0.5	1.2	-0.4	1.1	0.3
Body mass index (BMI)	0.9	3.7	5.5	-2.3	2.4	0.4
Impedance of leg (left)	0.6	3.0	3.6	-1.9	-1.9	1.4
Leg predicted mass (left)	1.9	10.1	19.4	4.4	-1.2	-3.1
Trunk fat mass	0.1	0.2	0.4	-0.7	0.5	-0.1
Waist circumference	0.0	0.1	0.1	-0.3	-0.0	-0.3
Number of incorrect matches in round	3.2	5.4	6.9	2.5	-2.6	-1.7
Past tobacco smoking	0.1	0.2	0.3	-0.0	-0.6	0.5
Alcohol usually taken with meals	0.8	1.2	3.4	1.9	0.2	-0.4
Nervous feelings	1.1	2.0	4.7	0.8	-2.2	-0.8
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.2	1.5	-0.9	-1.1	-1.2
Hearing difficulty/problems with background noise	0.7	1.2	3.5	0.1	-1.9	-0.4
Hair/balding pattern: Pattern 2	0.2	0.3	0.5	-0.7	0.3	-0.5
Had menopause	3.5	4.3	5.2	-2.2	2.3	1.7
Had other major operations	2.2	2.7	7.0	-2.6	1.0	0.1
Forced vital capacity (FVC)	2.6	10.1	21.9	4.7	-2.3	-1.8
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.7	0.2	-0.5	0.8
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	1.7	-1.3	-0.5	0.8
Qualifications: None of the above	0.7	1.4	1.9	-1.4	0.8	1.4
Financial difficulties in last 2 years	0.2	0.3	0.8	0.9	-0.1	0.1
Mouth/teeth dental problems	2.5	3.8	10.0	3.2	-0.8	-0.9
Heart attack	0.3	0.4	0.8	-0.5	-0.3	0.9
Allergy	0.7	1.6	3.2	1.8	1.0	0.8
Pain all over the body in last month	2.6	2.8	4.2	-2.1	1.2	1.6
Diabetes (self-reported)	0.8	1.2	3.5	0.1	1.9	-0.0
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	1.8	-1.1	1.4	0.7
Medication: Ramipril	0.3	0.3	0.7	0.9	-0.5	-0.1
Medication: Simvastatin	0.4	0.5	1.1	-0.1	1.0	0.7
Fluid intelligence score	0.4	0.9	2.1	-1.5	-0.4	-0.5
Illnesses of siblings	0.5	0.7	2.0	1.4	-0.3	-0.2
Neuroticism score	0.9	2.0	3.2	0.8	-1.8	-1.4
Weight	0.4	2.1	3.3	1.7	-0.4	-1.8
Impedance of arm (right)	0.4	1.9	4.9	-0.7	-0.7	2.2
Arm fat percentage (right)	1.5	5.8	9.6	-3.1	2.4	1.4
Trunk fat-free mass	2.8	15.9	29.1	5.4	-2.3	-3.7
Hip circumference	0.1	0.4	0.8	-0.2	0.9	-0.4
Time employed in main current job	0.4	0.5	0.8	0.4	-0.7	0.9
Alcohol intake versus 10 years previously	0.5	0.7	1.5	-0.3	-0.8	-1.2
Father’s age at death	3.2	4.3	10.7	3.3	-0.9	-1.2
Worrier / anxious feelings	0.9	1.8	2.4	1.5	-1.6	-0.8
Frequency of tiredness / lethargy in last 2 weeks	2.1	3.5	5.4	-1.5	-1.7	-2.3
Falls in the last year	1.1	1.6	3.1	-0.9	-0.9	-1.8
Hair/balding pattern: Pattern 3	1.3	1.9	3.6	1.2	-1.9	-0.7
Number of live births	0.8	1.2	2.2	-0.7	1.5	0.9
Forced expiratory volume in 1-second (FEV1)	1.9	6.3	12.4	3.5	-2.1	-1.5
Pulse rate	0.8	1.3	2.0	1.1	-0.9	-1.4
Happiness	0.1	0.1	0.2	-0.4	0.4	0.0
Noisy workplace	0.9	1.1	1.7	-0.3	-1.2	-1.3
Qualifications: A levels/AS levels or equivalent	0.8	1.8	4.3	2.1	-0.7	-0.7
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.3	3.6	-1.9	0.4	-0.1
Mouth/teeth dental problems: Dentures	0.9	1.6	3.6	-1.9	-1.0	0.0
Asthma	0.6	1.2	2.5	-0.7	-1.6	-0.9
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	1.2	-0.8	0.1	-1.1
Medication: Cholesterol lowering	0.5	0.8	1.7	-0.8	-0.1	1.3
Depression (self-reported)	0.2	0.3	0.7	0.1	0.2	-0.9
Medication: Lansoprazole	1.7	2.0	4.0	-0.1	-2.0	-1.4
Prospective memory result	0.2	0.2	0.4	0.6	0.0	0.4
Lung cancer (father)	1.4	1.6	3.3	-1.8	0.2	-1.3
Illnesses of mother	0.1	0.1	0.2	0.3	-0.5	-0.0
Forced expiratory volume in 1-second (FEV1), Best measure	2.4	7.7	12.0	3.5	-2.6	-2.1
Pulse wave Arterial Stiffness index	0.6	0.7	1.6	0.7	-0.3	-1.3
Impedance of arm (left)	0.4	1.7	3.4	-1.0	-0.8	1.9
Arm fat mass (right)	0.2	1.0	1.7	-1.1	1.3	0.0
Trunk predicted mass	2.8	15.8	28.6	5.3	-2.3	-3.7
Standing height	4.4	44.1	71.6	8.5	-5.9	-5.1
Length of working week for main job	1.9	2.1	5.4	0.1	-1.0	-2.3
Exposure to tobacco smoke at home	1.2	1.4	2.9	-1.7	0.8	0.7
Breastfed as a baby	2.6	3.2	8.9	3.0	-0.8	-0.2
Tense / ‘highly strung’	0.3	0.5	0.9	-0.0	-0.8	-0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.7	-0.8	0.0	0.1
Hair/balding pattern: Pattern 4	0.0	0.1	0.1	-0.4	-0.3	0.2
Birth weight of first child	0.2	0.4	0.6	0.4	-0.7	-0.7
Peak expiratory flow (PEF)	0.6	1.4	2.2	1.5	-1.2	-0.7
Pulse wave reflection index	0.4	0.5	0.8	-0.7	0.6	0.9
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.3	-0.3	-0.3	-1.2
Loud music exposure frequency	0.1	0.1	0.3	-0.5	0.1	0.3
Qualifications: O levels/GCSEs or equivalent	0.7	1.0	2.2	0.8	-0.5	-1.5
Mouth/teeth dental problems: Bleeding gums	0.3	0.3	0.6	0.3	-0.5	-0.8
Blood clot in the leg (DVT)	3.6	4.6	10.7	3.3	-1.6	-0.8
Medication: Paracetamol	3.8	6.3	11.0	-3.3	2.7	0.8
Headache pain in last month	0.1	0.2	0.6	0.2	-0.8	-0.2
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	2.8	1.7	0.4	-0.0
Glaucoma (self-reported)	0.2	0.2	0.7	-0.2	0.1	-0.8
Gout (self-reported)	0.2	0.2	0.4	-0.6	0.3	0.4
Hypothyroidism/myxoedema (self-reported)	0.9	1.8	4.4	-0.3	-0.9	-2.1
Medication: Amlodipine	0.9	1.3	1.9	-1.4	1.0	-1.0
Medication: Ventolin 100micrograms inhaler	2.8	3.6	9.1	-3.0	0.6	1.2
Birth weight	4.9	10.5	17.4	4.2	-3.3	-1.8
Chronic bronchitis/emphysema (mother)	0.3	0.3	0.7	0.8	-0.0	-0.4
High blood pressure (siblings)	1.0	1.4	2.1	-1.3	1.4	-0.7
Forced vital capacity (FVC), Best measure	3.7	13.4	24.7	5.0	-3.0	-2.6
Body fat percentage	1.3	5.1	9.7	-3.1	1.9	1.4
Leg fat percentage (right)	1.4	5.2	12.1	-3.5	1.6	1.0
Arm fat-free mass (right)	2.1	10.6	15.9	4.0	-1.8	-3.5
Exposure to tobacco smoke outside home	3.3	4.4	12.3	-3.5	0.9	0.3
Comparative body size at age 10	0.6	1.8	5.2	2.3	0.1	-0.3
Number of full brothers	0.8	1.0	2.1	0.7	-0.5	-1.5
Worry too long after embarrassment	0.2	0.3	0.5	0.5	-0.7	-0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	0.9	0.5	-0.9	0.2
Wheeze or whistling in the chest in last year	1.0	1.8	3.3	-0.8	-1.8	-1.2
Number of children fathered	0.4	0.5	1.3	1.2	-0.2	-0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	0.6	0.6	-0.7	0.8
Age at first live birth	1.1	2.0	5.1	2.3	0.0	-0.9
Pulse wave peak to peak time	0.3	0.4	1.0	-0.3	-0.2	1.0
Health satisfaction	0.1	0.2	0.5	0.1	-0.7	-0.3
Shortness of breath walking on level ground	0.4	0.5	0.6	-0.7	-0.8	0.6
Qualifications: College or University degree	0.5	1.7	5.0	2.2	-0.1	-0.1
Eye problems/disorders: None of the above	2.2	2.5	4.0	-1.5	2.0	1.1
Mouth/teeth dental problems: Loose teeth	5.9	7.0	12.6	-1.4	3.5	2.5
Emphysema/chronic bronchitis	1.7	1.9	3.5	-1.0	-1.2	-1.9
Medication for pain relief, constipation, heartburn	1.5	2.5	6.0	2.4	-1.2	-0.3
Neck or shoulder pain in last month	0.4	0.5	1.5	0.2	-0.2	-1.2
Medication: Blood pressure	0.6	1.1	3.1	-1.8	0.1	-0.4
Angina (self-reported)	0.6	0.8	1.6	0.6	-0.7	-1.3
Migraine (self-reported)	0.6	0.7	1.0	-0.9	1.0	0.6
Medication: Ibuprofen	0.5	0.6	1.5	-0.5	0.3	-1.2
Medication: Allopurinol	0.1	0.1	0.3	-0.1	0.4	0.5
Medication: Omeprazole	0.6	0.7	1.8	-0.4	-0.3	-1.3
Medication: Seretide 50 evohaler	0.9	1.1	2.6	-0.7	0.2	-1.6
Mean time to correctly identify matches	0.5	1.0	2.0	-1.0	0.5	1.4
Heart disease (mother)	1.4	1.7	5.0	-2.2	-0.4	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	0.9	-0.5	-0.8	-0.9
Whole body fat mass	0.1	0.4	0.8	-0.9	0.7	-0.2
Leg fat mass (right)	0.1	0.3	0.6	-0.7	0.4	-0.5
Arm predicted mass (right)	2.4	12.2	18.8	4.3	-2.0	-3.7
Pulse rate, automated reading	0.7	2.3	5.3	0.1	-1.3	-2.3
Alcohol intake frequency.	0.2	0.5	0.9	-0.8	0.9	0.1
Comparative height size at age 10	7.0	38.3	63.4	8.0	-5.0	-5.1
Number of full sisters	0.1	0.1	0.4	-0.2	0.2	-0.6
Suffer from ‘nerves’	0.5	0.8	1.3	0.7	-1.1	-0.8
Overall health rating	1.4	3.0	7.4	-2.7	0.6	-1.2
Chest pain or discomfort	1.0	1.5	3.6	-1.9	-0.1	0.9
Had major operations	0.8	1.0	1.3	-1.0	0.8	-1.1
Age at last live birth	3.4	5.0	10.2	3.2	-1.3	-1.8
Family relationship satisfaction	0.5	0.6	1.6	0.3	1.3	0.1
Leg pain on walking	1.3	1.6	3.3	0.5	-1.8	-1.1
Qualifications: NVQ or HND or HNC or equivalent	1.7	2.1	5.9	-2.4	0.5	0.3
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.5	-1.2	-0.2	-0.1
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.3	1.1	-0.3	0.2
Medication: Aspirin	0.1	0.1	0.2	0.1	-0.2	0.4
Supplements: Vitamin C	0.8	0.9	1.8	1.0	-1.3	-0.1
Knee pain experienced in last month	1.0	1.6	2.6	-1.6	-0.0	-1.5
Hypertension (Self-reported)	0.9	2.6	3.5	-1.9	1.9	-0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.3	0.4	0.3	-0.7	0.5
Illnesses of father: Heart disease	1.0	1.4	3.2	0.5	-0.9	-1.8
Illnesses of siblings: Diabetes	1.7	2.1	3.2	-1.8	-0.7	-1.6
Smoking status: Previous	0.0	0.1	0.2	0.4	0.2	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	4.5	9.3	17.3	4.2	-2.5	-2.1
Whole body fat-free mass	2.6	14.9	27.5	5.2	-2.0	-3.6
Leg fat-free mass (right)	2.4	12.8	24.0	4.9	-1.7	-3.4
Arm fat percentage (left)	1.5	5.9	10.6	-3.3	2.3	1.2
Average weekly red wine intake	0.6	0.9	2.3	1.5	-0.4	0.4
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.3	0.3	-0.6	-1.2
Mood swings	0.6	1.2	2.2	0.5	-1.5	-1.0
Loneliness, isolation	0.2	0.3	0.5	-0.0	-0.6	0.7
Long-standing illness, disability or infirmity	0.9	1.4	4.2	-2.0	-0.1	-0.3
Ever had bowel cancer screening	0.2	0.2	0.5	-0.1	0.7	0.4
Diabetes diagnosed by doctor	1.5	2.5	6.9	-0.3	2.6	0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.3	0.1	0.5	0.5
Friendships satisfaction	0.1	0.2	0.4	0.2	-0.6	0.2
Qualifications: nursing, teaching	1.1	1.7	4.7	2.2	-0.4	-0.6
Commuting to job workplace: Walk	0.5	0.5	1.1	1.1	0.3	-0.6
Eye problems/disorders: Cataract	2.3	2.6	4.4	2.1	-0.9	-1.6
Mouth/teeth dental problems: Mouth ulcers	1.7	2.7	4.0	-2.0	1.6	1.2
Medication for cholesterol	2.1	3.1	5.5	2.3	-2.0	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.1	2.2	-0.9	-0.7	-1.5
Back pain experienced in last month	0.3	0.4	0.8	-0.9	0.2	-0.6
Mineral and other dietary supplements	1.0	1.3	3.3	-1.8	0.8	0.2
Breast cancer (self-reported)	0.2	0.2	0.4	0.6	0.3	0.4
Asthma (self-reported)	0.7	1.3	2.7	-0.7	-1.6	-0.9
Osteoporosis (self-reported)	3.0	3.8	7.0	1.1	-1.8	-2.6
Osteoarthritis (self-reported)	0.4	0.5	1.2	-1.1	0.5	0.3
Medication: Aspirin	0.1	0.1	0.2	0.3	-0.4	0.3
Medication: Gliclazide	1.7	1.9	4.0	2.0	-1.1	-0.7
Illnesses of father: None of the above (group 1)	1.0	1.3	3.7	-0.3	-0.0	1.9
Smoking status: Current	0.6	1.0	2.4	-1.6	0.5	-0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.6	1.9	1.4	-1.2	-1.2
Whole body water mass	2.5	14.2	26.0	5.1	-1.9	-3.6
Leg predicted mass (right)	2.4	12.8	24.0	4.9	-1.7	-3.4
Arm fat mass (left)	0.3	1.2	1.8	-1.3	1.4	-0.2
Number of self-reported non-cancer illnesses	1.0	1.8	4.2	-2.1	0.3	-1.0
Average weekly champagne plus white wine intake	0.5	0.7	1.8	-0.2	1.4	-0.2
Miserableness	1.1	1.9	3.9	0.0	-1.4	-2.0
Guilty feelings	0.4	0.7	1.9	-0.2	-1.4	0.0
Wears glasses or contact lenses	0.4	0.4	0.7	0.1	-0.8	-0.8
Ever taken oral contraceptive pill	0.7	0.8	1.9	-0.2	-1.4	0.7
Hearing aid user	1.0	1.1	3.1	0.5	-1.8	0.3
Mother’s age at death	0.5	0.6	1.4	0.3	-1.2	0.5
Financial situation satisfaction	0.6	0.7	1.2	1.0	0.1	-1.1
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.4	-1.2	-0.5	0.5
Commuting to job workplace: Public transport	1.2	1.4	3.9	2.0	-0.1	0.6
Eye problems/disorders: Glaucoma	0.1	0.1	0.2	-0.2	-0.4	-0.4
Medication: Blood pressure	1.2	2.3	4.5	-2.1	1.6	0.1
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.7	-0.2	-0.6	-0.9
Supplements: Fish oil (including cod liver oil)	1.2	1.6	3.2	1.8	-1.2	-0.2
High cholesterol (Self-reported)	0.0	0.0	0.1	-0.0	0.2	0.3
Medication: Bendroflumethiazide	0.6	0.9	2.4	-1.6	-0.2	-0.4
Medication: Paracetamol	2.8	4.3	6.3	-2.5	2.4	0.8
Medication: Lisinopril	0.6	0.8	0.9	-0.9	0.9	-0.8
Medication: Atorvastatin	1.1	1.3	2.9	0.5	-1.7	-0.9
Illnesses of father: High blood pressure	0.9	1.2	1.9	-1.4	0.9	-0.9
Alcohol drinker status: Never	0.2	0.2	0.4	0.6	0.1	-0.6
Ever smoked	0.4	0.6	0.9	-0.9	0.7	-0.8
Basal metabolic rate	2.0	11.1	20.0	4.5	-1.7	-3.2
Leg fat percentage (left)	1.5	5.3	12.5	-3.5	1.6	1.0
Arm fat-free mass (left)	1.8	9.1	14.6	3.8	-1.7	-3.1
Number of operations (self-reported)	0.5	0.7	1.8	-1.3	0.1	-0.6
Average weekly beer plus cider intake	1.1	1.6	3.3	-1.8	-0.6	-1.1
Irritability	1.4	2.4	3.5	0.9	-1.7	-1.9
Risk taking	2.5	3.7	6.4	-2.5	1.6	1.4
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.2	1.1	-0.7	-0.3
Fractured/broken bones in last 5 years	0.4	0.5	0.7	-0.8	0.8	0.0
Age started oral contraceptive pill	0.3	0.4	0.7	0.8	0.5	0.6
Diastolic blood pressure, automated reading	2.2	6.9	11.0	-3.1	3.3	-0.4
Ever depressed for a whole week	0.9	1.1	2.7	-0.7	0.3	1.6
Unable to work because of sickness or disability	3.0	3.8	10.0	-3.2	0.5	-1.1
Commuting to job workplace: Cycle	0.4	0.5	1.3	0.2	-0.4	1.1
Myopia	0.1	0.2	0.3	-0.5	0.3	-0.6
Vascular/heart problems diagnosed by doctor	1.3	3.5	5.0	2.0	-2.2	1.3
Cholesterol lowering medication	0.3	0.4	1.0	0.4	0.4	-1.0
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	2.4	0.1	-0.8	-1.5
Pain experienced in last month	1.1	1.8	4.2	0.6	1.0	2.1
Supplements: Calcium	1.9	2.1	4.1	1.5	-0.4	-2.0
Basal cell carcinoma (self-reported)	0.3	0.3	0.9	-0.3	0.0	1.0
Heart attack/myocardial infarction (self-reported)	0.2	0.2	0.3	-0.2	-0.5	0.5
Deep venous thrombosis (DVT) (self-reported)	3.8	4.9	10.1	3.2	-1.9	-0.9
Heart disease (siblings)	0.3	0.4	0.5	-0.4	-0.7	-0.7
Alcohol drinker status: Previous	0.9	1.0	2.8	-0.1	1.7	0.4
Pack years of smoking	0.5	0.7	1.5	-0.7	-0.1	1.2
Impedance of whole body	0.6	2.8	4.0	-1.7	-1.3	2.0
Leg fat mass (left)	0.1	0.3	0.6	-0.7	0.3	-0.5
Arm predicted mass (left)	1.7	8.5	13.2	3.6	-1.5	-3.1