Best TWAS P=7.4e-17 · Best GWAS P=1.29e-11 conditioned to 0.479
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | CRELD1 | 0.46 | 0.16 | enet | 51 | 0.27 | 2.2e-22 | -6.8 | -8.3 | 7.4e-17 | 0.76 | 0.00 | 1.00 | TRUE |
| 7 | GTEx | Cells Transformed fibroblasts | CRELD1 | 0.39 | 0.19 | enet | 39 | 0.28 | 4.5e-21 | -6.8 | -8.2 | 1.9e-16 | 0.79 | 0.00 | 1.00 | FALSE |
| 13 | GTEx | Skin Sun Exposed Lower leg | CRELD1 | 0.29 | 0.15 | enet | 36 | 0.23 | 8.2e-19 | -6.8 | -7.7 | 1.6e-14 | 0.75 | 0.00 | 1.00 | FALSE |
| 4 | GTEx | Artery Aorta | RP11-1020A11.1 | 0.15 | 0.01 | lasso | 3 | 0.00 | 4.0e-01 | -6.8 | -7.5 | 5.9e-14 | 0.91 | 0.01 | 0.83 | FALSE |
| 3 | GTEx | Artery Aorta | CRELD1 | 0.30 | 0.07 | lasso | 7 | 0.12 | 2.4e-07 | -6.8 | -7.3 | 3.7e-13 | 0.88 | 0.00 | 1.00 | FALSE |
| 8 | GTEx | Cells Transformed fibroblasts | RP11-1020A11.1 | 0.20 | 0.10 | enet | 67 | 0.09 | 1.9e-07 | -6.8 | -7.0 | 2.0e-12 | 0.66 | 0.00 | 1.00 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | CRELD1 | 0.19 | 0.12 | lasso | 4 | 0.10 | 4.1e-06 | -6.8 | -7.0 | 2.5e-12 | 0.91 | 0.00 | 1.00 | FALSE |
| 5 | GTEx | Artery Tibial | CRELD1 | 0.43 | 0.15 | enet | 41 | 0.21 | 1.1e-16 | -6.8 | -6.8 | 1.2e-11 | 0.78 | 0.00 | 1.00 | FALSE |
| 10 | GTEx | Esophagus Muscularis | CRELD1 | 0.21 | 0.10 | lasso | 1 | 0.08 | 1.7e-05 | -6.8 | -6.8 | 1.3e-11 | 1.00 | 0.00 | 1.00 | FALSE |
| 6 | GTEx | Breast Mammary Tissue | CRELD1 | 0.25 | 0.19 | lasso | 6 | 0.18 | 2.2e-09 | -6.8 | -6.7 | 2.6e-11 | 1.00 | 0.00 | 1.00 | FALSE |
| 12 | GTEx | Skin Not Sun Exposed Suprapubic | CRELD1 | 0.29 | 0.07 | enet | 25 | 0.13 | 9.7e-08 | -1.9 | -6.6 | 4.0e-11 | 0.44 | 0.02 | 0.96 | FALSE |
| 14 | GTEx | Testis | CRELD1 | 0.22 | 0.22 | lasso | 8 | 0.26 | 1.1e-11 | 4.3 | -6.5 | 7.2e-11 | 0.67 | 0.12 | 0.88 | FALSE |
| 11 | GTEx | Nerve Tibial | CRELD1 | 0.17 | 0.05 | enet | 9 | 0.13 | 2.0e-09 | -6.8 | -6.5 | 1.0e-10 | 0.81 | 0.00 | 1.00 | FALSE |
| 15 | METSIM | Adipose | CRELD1 | 0.23 | 0.16 | bslmm | 480 | 0.21 | 3.1e-30 | -6.8 | -6.5 | 1.0e-10 | 0.74 | 0.00 | 1.00 | FALSE |
| 17 | The Cancer Genome Atlas | Soft Tissue Sarcoma | CRELD1 | 0.12 | 0.01 | enet | 22 | 0.04 | 1.4e-03 | -2.7 | -6.1 | 1.2e-09 | 0.39 | 0.01 | 0.09 | FALSE |
| 9 | GTEx | Esophagus Mucosa | CRELD1 | 0.14 | 0.06 | enet | 7 | 0.11 | 7.7e-08 | -6.8 | -5.9 | 2.8e-09 | 0.81 | 0.00 | 0.99 | FALSE |
| 16 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | CRELD1 | 0.03 | 0.00 | blup | 49 | 0.01 | 1.4e-02 | -3.2 | -5.3 | 1.2e-07 | 0.35 | 0.00 | 0.05 | FALSE |