Best TWAS P=2.02e-12 · Best GWAS P=6.79e-12 conditioned to 0.0119
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Visceral Omentum | MKRN2 | 0.20 | 0.05 | enet | 11 | 0.09 | 1.7e-05 | -6.6 | -6.2 | 5.1e-10 | -0.81 | 0.01 | 0.98 | FALSE |
2 | GTEx | Artery Tibial | MKRN2 | 0.27 | 0.09 | enet | 20 | 0.25 | 3.1e-19 | -2.6 | -6.1 | 8.3e-10 | -0.68 | 0.27 | 0.73 | FALSE |
3 | GTEx | Artery Tibial | TSEN2 | 0.14 | 0.10 | lasso | 6 | 0.07 | 5.3e-06 | -6.0 | 6.2 | 7.0e-10 | 0.82 | 0.18 | 0.82 | FALSE |
4 | GTEx | Cells EBV-transformed lymphocytes | MKRN2 | 0.32 | 0.26 | lasso | 4 | 0.21 | 1.5e-07 | -5.2 | 5.3 | 1.1e-07 | 0.74 | 0.57 | 0.39 | FALSE |
5 | GTEx | Esophagus Gastroesophageal Junction | MKRN2 | 0.17 | 0.10 | enet | 13 | 0.07 | 1.9e-03 | -6.6 | -7.0 | 2.0e-12 | -0.73 | 0.04 | 0.86 | TRUE |
6 | GTEx | Esophagus Muscularis | MKRN2 | 0.15 | 0.05 | lasso | 8 | 0.12 | 8.9e-08 | 6.4 | -6.2 | 6.8e-10 | -0.76 | 0.02 | 0.98 | FALSE |
7 | GTEx | Heart Atrial Appendage | MKRN2 | 0.14 | 0.09 | lasso | 3 | 0.08 | 1.5e-04 | -6.1 | -6.5 | 6.5e-11 | -0.76 | 0.05 | 0.94 | FALSE |
8 | GTEx | Heart Left Ventricle | MKRN2 | 0.21 | 0.05 | enet | 15 | 0.14 | 1.1e-07 | -6.6 | -6.7 | 2.3e-11 | -0.74 | 0.03 | 0.97 | FALSE |
9 | GTEx | Thyroid | MKRN2 | 0.11 | 0.04 | enet | 14 | 0.05 | 6.3e-05 | -6.5 | -5.7 | 1.5e-08 | -0.70 | 0.06 | 0.93 | FALSE |
10 | YFS | Blood | RAF1 | 0.02 | 0.03 | lasso | 2 | 0.03 | 2.1e-10 | -6.4 | -6.5 | 5.8e-11 | -0.77 | 0.05 | 0.95 | FALSE |
11 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | RAF1 | 0.03 | 0.02 | blup | 59 | 0.02 | 1.6e-03 | -4.5 | 5.8 | 4.9e-09 | 0.61 | 0.03 | 0.88 | FALSE |
12 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | RAF1 | 0.31 | 0.16 | lasso | 4 | 0.16 | 3.8e-06 | 6.7 | 6.2 | 4.9e-10 | 0.74 | 0.01 | 0.98 | FALSE |