Best TWAS P=6.25e-09 · Best GWAS P=2.38e-08 conditioned to 0.00796
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | LRRC58 | 0.08 | 0.03 | enet | 11 | 0.05 | 5.4e-05 | 4.1 | -5.3 | 1.4e-07 | 0.74 | 0.00 | 0.99 | TRUE |
| 2 | GTEx | Brain Frontal Cortex BA9 | IQCB1 | 0.34 | 0.24 | enet | 48 | 0.22 | 1.7e-06 | -3.8 | -5.5 | 3.1e-08 | -0.02 | 0.26 | 0.28 | FALSE |
| 3 | GTEx | Liver | SEC22A | 0.21 | -0.01 | lasso | 5 | 0.00 | 2.3e-01 | 4.8 | -5.3 | 1.2e-07 | 0.01 | 0.04 | 0.60 | FALSE |
| 4 | NTR | Blood | HCLS1 | 0.06 | 0.04 | bslmm | 351 | 0.05 | 1.2e-16 | -3.4 | 5.6 | 2.7e-08 | 0.02 | 0.74 | 0.07 | FALSE |
| 5 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SEC22A | 0.01 | 0.01 | blup | 76 | 0.01 | 2.4e-02 | 4.9 | -5.2 | 2.3e-07 | 0.01 | 0.03 | 0.92 | FALSE |
| 6 | The Cancer Genome Atlas | Colon Adenocarcinoma | IQCB1 | 0.61 | 0.27 | blup | 50 | 0.34 | 3.1e-20 | -3.4 | -5.7 | 1.2e-08 | -0.03 | 0.60 | 0.11 | TRUE |
| 7 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SEC22A | 0.04 | 0.01 | blup | 76 | 0.04 | 2.1e-05 | -4.7 | -5.8 | 6.2e-09 | 0.01 | 0.04 | 0.94 | TRUE |