Best TWAS P=2.46e-23 · Best GWAS P=8.72e-22 conditioned to 1.54e-05
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | RP11-723O4.9 | 0.12 | 0.04 | lasso | 5 | 0.06 | 3.4e-05 | 1.5 | 6.4 | 2.0e-10 | -0.52 | 0.08 | 0.86 | FALSE |
| 2 | GTEx | Brain Cortex | COPG1 | 0.24 | 0.00 | enet | 57 | 0.03 | 5.3e-02 | -8.2 | -5.5 | 4.9e-08 | 0.50 | 0.02 | 0.48 | FALSE |
| 3 | GTEx | Testis | HMCES | 0.75 | 0.56 | lasso | 8 | 0.55 | 8.4e-29 | 6.4 | 6.4 | 1.2e-10 | -0.15 | 1.00 | 0.00 | FALSE |
| 4 | METSIM | Adipose | COPG1 | 0.04 | 0.02 | bslmm | 303 | 0.03 | 7.6e-06 | 6.5 | -5.9 | 3.0e-09 | 0.33 | 0.78 | 0.02 | FALSE |
| 5 | YFS | Blood | H1FX | 0.02 | 0.01 | lasso | 3 | 0.01 | 1.4e-03 | -8.2 | 8.2 | 1.9e-16 | -0.84 | 0.10 | 0.44 | FALSE |
| 6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | H1FX | 0.02 | 0.02 | lasso | 5 | 0.03 | 6.5e-07 | 6.6 | 9.9 | 2.5e-23 | -0.62 | 0.10 | 0.88 | TRUE |
| 7 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | H1FX | 0.02 | 0.00 | blup | 36 | 0.00 | 5.1e-01 | -9.6 | 9.5 | 2.5e-21 | -0.65 | 0.00 | 0.68 | FALSE |