Hub : Genes

LRRC58

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Subcutaneous 0.0780 0.0330 0.00260 0.034 NA 0.051 NA 0.040 7.8e-04 NA 5.4e-05 NA 3.2e-04
2 GTEx Brain Hippocampus 0.3502 0.1139 0.00059 -0.002 NA 0.003 NA -0.012 3.7e-01 NA 2.7e-01 NA 8.6e-01
3 GTEx Muscle Skeletal 0.0687 0.0262 0.00032 0.022 NA 0.028 NA 0.017 2.6e-03 NA 7.7e-04 NA 7.2e-03
4 GTEx Pituitary 0.2860 0.1140 0.00720 0.000 NA 0.006 NA 0.029 3.1e-01 NA 2.2e-01 NA 6.2e-02
5 NTR Blood 0.0218 0.0099 0.00280 -0.001 0.005 0.000 0.006 0.000 6.7e-01 5.9e-03 2.3e-01 4.8e-03 2.8e-01
6 YFS Blood 0.1247 0.0261 0.00000 0.142 0.114 0.137 0.141 0.140 4.5e-44 2.7e-35 1.1e-42 9.2e-44 1.7e-43
7 TCGA Kidney Renal Clear Cell Carcinoma 0.0383 0.0210 0.00310 0.002 0.007 0.003 NA 0.000 2.0e-01 4.4e-02 1.4e-01 NA 3.4e-01
8 TCGA Lung Squamous Cell Carcinoma 0.0209 0.0126 0.00750 0.018 0.007 0.003 NA 0.010 3.1e-03 4.8e-02 1.5e-01 NA 2.4e-02
9 TCGA Prostate Adenocarcinoma 0.0326 0.0189 0.00210 0.009 0.025 0.021 NA 0.016 3.6e-02 9.8e-04 2.4e-03 NA 6.9e-03
10 TCGA Testicular Germ Cell Tumors 0.1530 0.0770 0.00010 0.091 0.094 0.107 NA 0.103 4.0e-04 3.3e-04 1.3e-04 NA 1.8e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bipolar Disorder (2018) 0.7 1.2 3.7 1.9 0.0 -0.6 1.2 0.2 -1.0 1.5 1.4 0.7 0.9
Bipolar Disorder or Schizophrenia 0.5 1.1 6.0 1.5 0.0 0.1 0.4 -0.5 -0.4 0.9 -0.1 1.2 2.4
Depressed Affect (Nagel 2018) 0.2 0.4 1.8 -0.1 0.0 0.6 0.8 -1.3 0.4 -0.8 -0.4 -0.3 -0.3
Depression (Nagel 2018) 0.1 0.1 0.3 0.4 0.0 0.4 -0.1 -0.4 -0.4 0.1 -0.0 0.6 0.2
Intelligence (Savage-Jansen 2018) 0.2 0.6 1.5 1.2 0.0 -0.1 1.2 -0.4 1.1 -0.6 -0.5 -0.6 0.5
Neuroticism (Nagel 2018) 0.2 0.5 2.6 -0.4 0.0 1.6 1.0 -0.5 0.2 -0.4 -0.8 0.3 0.5
Schizophrenia (2018) 0.5 1.0 6.0 0.4 0.0 0.7 -0.5 -0.8 0.3 -0.0 -1.3 1.0 2.5
Schizophrenia vs Biploar Disorder 0.1 0.1 0.4 -0.7 0.0 -0.1 0.1 -0.0 -0.1 -0.5 0.0 0.0 -0.2
Worry (Nagel 2018) 0.6 1.3 4.1 -0.5 0.0 1.9 2.0 0.5 -0.0 0.0 -1.3 1.0 1.4
Alzheimer’s Disease (in mother) 0.5 0.6 1.9 1.4 0.0 0.1 0.8 0.4 -1.0 0.8 0.2 1.0 0.7
Alzheimer’s Disease (in father) 1.0 1.1 3.2 -0.2 0.0 -0.9 1.3 -1.8 0.9 -1.3 0.3 -1.2 -1.1
Alzheimer’s Disease (including proxy) 0.5 0.7 3.8 0.9 0.0 -0.9 1.9 -0.6 -0.4 0.6 0.9 0.2 0.1
Crohns Disease (2017) 1.4 3.1 11.7 1.2 0.0 -2.2 0.5 0.6 -1.6 2.7 3.4 -0.3 -1.6
Irritable Bowel Disease (IBD) 0.6 1.3 5.2 0.8 0.0 -1.2 -0.2 -0.6 -0.5 1.0 2.3 -0.9 -1.9
Ulcerative Colitis (UC) 0.3 0.5 1.5 0.5 0.0 0.7 -0.7 -1.1 -0.1 -0.6 0.3 -0.6 -1.2
Major Depression (MDD) 0.6 0.8 4.5 -0.4 0.0 -0.9 2.1 0.5 0.4 0.5 0.5 -0.7 -0.9
Reaction Time 0.3 0.6 3.1 -0.5 0.0 -0.0 1.8 -1.4 0.4 -0.7 0.3 -0.3 -0.4
Verbal and Numeric Reasoning (VNR) 0.1 0.3 1.5 1.2 0.0 -0.4 0.7 0.4 0.1 0.2 0.1 -0.0 0.5
Breast Cancer 0.2 0.5 2.2 -1.5 0.0 -0.4 -1.1 0.2 0.2 -0.3 -0.0 -0.4 -1.0
Ovarian Cancer 1.4 1.9 4.8 2.2 0.0 2.2 -1.1 -0.2 -0.5 -0.3 -1.2 1.4 2.1
Prostate Cancer 0.9 1.3 4.7 0.2 0.0 -2.2 0.6 -0.1 0.9 -0.3 1.4 -1.7 -1.4
Age at First Birth 0.5 0.8 2.8 1.7 0.0 -1.1 1.0 0.6 0.8 -0.3 -0.7 -0.0 1.1
Bipolar Disorder (2011) 0.4 0.4 1.3 0.6 0.0 -0.6 -0.2 0.3 -0.6 0.9 1.1 0.3 0.6
Body Mass Index (BMI) (2010) 0.4 0.6 3.1 -1.8 0.0 -0.5 -0.6 -1.2 -0.1 0.1 0.5 -0.2 -0.4
Coronary Artery Disease (CAD) 0.3 0.4 2.0 -1.1 0.0 -0.1 1.4 -0.2 0.3 -0.1 0.4 -0.5 -0.2
Crohns Disease (2012) 1.5 2.4 9.9 -0.0 0.0 -2.0 0.9 0.9 -1.1 2.4 3.1 -0.4 -1.2
Mean Putamen Volume 0.9 1.0 3.8 -1.2 0.0 -0.6 1.6 -0.4 -0.1 -0.5 0.8 -0.8 -1.9
Fasting Glucose 0.7 0.8 1.6 0.1 0.0 1.2 -1.1 -1.1 1.3 -1.2 -0.6 -0.9 -0.3
HbA1C 1.1 1.3 6.9 -0.1 0.0 0.4 -2.6 1.4 -0.6 0.5 -0.3 1.0 1.3
HDL Cholesterol 0.6 1.1 4.3 1.3 0.0 -1.3 2.1 0.1 0.6 0.8 1.1 -0.8 -0.1
LDL Cholesterol 0.3 0.4 1.6 -0.6 0.0 -0.7 0.4 -0.3 -0.3 0.6 1.1 -0.6 -1.2
Lupus 1.0 1.5 6.9 1.6 0.0 0.8 0.4 -1.0 0.8 -0.5 -1.5 0.8 2.6
Neuroticism (2016) 0.1 0.2 1.0 -0.1 0.0 0.2 1.0 0.2 -0.1 -0.7 -0.1 -0.2 -0.3
Primary Biliary Cirrhosis 0.6 0.8 2.6 -0.9 0.0 0.6 1.4 -1.6 0.4 -1.0 -1.0 -0.1 0.4
Rheumatoid Arthritis 0.7 0.9 3.6 -0.7 0.0 0.2 1.0 -0.9 1.0 -0.8 -1.9 0.4 1.2
Schizophrenia (2014) 0.4 1.0 4.8 1.0 0.0 -0.1 0.8 -0.2 -0.6 1.2 0.1 1.2 2.2
Triglycerides 0.3 0.5 2.4 -1.0 0.0 -0.1 -0.3 -0.5 -0.1 -0.2 0.9 -0.9 -1.6
Type 2 Diabetes (T2D) (2012) 1.6 1.9 5.3 1.9 0.0 1.0 -0.5 0.8 -1.1 0.2 -1.7 2.0 2.3
Ulcerative Colitis 0.3 0.5 2.3 0.3 0.0 0.3 0.2 -1.0 0.1 -0.8 0.2 -0.7 -1.5
Blood Eosinophil Count 0.4 3.2 11.0 -3.3 0.0 1.9 -2.6 -0.2 0.1 -2.0 -1.8 -0.3 -1.7
Blood Platelet Count 0.2 2.1 4.8 -0.2 0.0 2.2 -1.6 -1.9 1.4 -2.0 -1.8 -0.5 0.2
Blood Red Count 0.2 1.9 8.1 2.2 0.0 -1.2 0.7 -2.9 1.3 -0.6 0.7 -1.4 0.1
Blood White Count 0.2 1.2 3.2 -0.7 0.0 1.4 -1.1 -1.8 0.1 -1.1 -1.6 0.2 -1.2
Heel T-Score 0.5 3.7 12.0 -1.1 0.0 2.1 -1.3 -1.1 2.4 -3.0 -3.5 -0.9 0.6
BMI 0.3 1.6 5.8 0.2 0.0 2.4 1.8 -1.8 -0.1 -0.5 -1.5 0.7 0.6
Height 0.5 10.6 38.8 -6.2 0.0 -2.0 0.2 -2.4 3.8 -3.6 -0.7 -4.1 -3.6
Waist Hip Ratio (WHR) 0.7 3.4 9.9 3.1 0.0 -0.0 0.5 1.8 -1.6 2.0 -0.2 2.3 2.9
Systolic Blood Pressure 0.1 0.7 2.4 1.6 0.0 0.7 -0.6 0.6 -0.7 0.4 -0.4 1.1 1.4
Smoking Status 0.6 1.5 5.9 0.7 0.0 -1.0 -0.2 1.0 -1.5 2.4 1.1 1.5 0.7
Allergy or Eczema 0.6 1.6 4.3 2.1 0.0 -0.3 0.4 1.9 -1.1 1.1 -0.6 1.6 1.7
Cardiovascular Disease 0.1 0.4 1.4 0.1 0.0 0.6 -0.1 -0.7 1.2 -0.3 -0.3 -0.5 1.1
Hypothyroidism (self reported) 0.5 1.2 3.3 -0.9 0.0 -1.6 1.8 0.5 0.8 1.3 1.1 -1.0 -0.3
Respiratory disease 0.8 1.9 3.9 1.3 0.0 -1.7 -1.2 2.0 -1.0 1.8 2.0 0.0 -0.9
Type 2 Diabetes (T2D) (2018) 1.0 1.8 4.1 1.6 0.0 1.8 1.6 2.0 -1.4 0.2 -0.9 1.6 0.8
Lung FEV1/FVC ratio 0.8 4.0 13.0 3.0 0.0 2.0 1.0 -0.5 -0.7 0.3 -2.4 2.5 3.6
Lung FVC 1.3 6.5 24.8 5.0 0.0 0.0 1.8 2.6 -2.0 2.8 -0.0 2.8 3.1
Neuroticism 0.2 0.6 2.8 -1.0 0.0 1.7 0.7 -0.1 0.1 -0.6 -1.0 0.4 0.3
Chronotype (morning person) 1.2 2.8 13.5 -1.4 0.0 2.3 -3.7 -0.2 1.3 -1.7 -1.6 -0.5 0.2
Hair Pigment 0.1 3.2 8.6 2.4 0.0 2.1 -1.4 1.2 -2.9 1.0 -0.2 2.7 1.2
Tanning 0.1 1.8 5.2 -0.0 0.0 1.1 -0.8 -1.7 1.4 -2.1 -2.3 -0.1 1.1
Hand grip strength (left) 1.5 4.0 9.3 -3.1 0.0 -2.1 2.3 -1.0 1.3 0.1 2.4 -2.7 -2.4
Number of treatments/medications taken 0.8 1.5 3.5 1.0 0.0 1.9 0.4 1.4 -1.1 0.4 -1.3 1.9 1.3
Average weekly spirits intake 0.2 0.2 1.6 -0.4 0.0 -0.1 -1.3 -0.1 -0.1 -0.1 -0.6 0.1 -0.5
Sensitivity / hurt feelings 1.1 1.9 9.1 -2.7 0.0 1.0 -3.0 -0.9 -0.1 -0.1 -0.2 0.0 -1.0
Frequency of depressed mood in last 2 weeks 0.4 0.5 1.1 0.7 0.0 -0.8 -0.9 -1.1 -0.3 0.6 0.9 -0.2 -0.9
Hearing difficulty/problems: Yes 3.2 4.9 12.0 1.1 0.0 0.4 2.8 2.2 -3.4 3.5 1.0 2.9 1.1
Relative age of first facial hair 0.1 0.3 1.1 -0.5 0.0 -0.7 0.6 -0.0 0.3 0.5 1.1 -0.6 -0.1
Other serious medical condition/disability diagnosed by doctor 0.6 0.8 2.1 -0.8 0.0 1.3 0.2 0.7 -0.9 0.4 -1.0 1.5 1.1
Ever used hormone-replacement therapy (HRT) 0.9 1.1 2.6 -1.5 0.0 -0.8 -0.3 0.3 -1.4 1.4 1.3 0.3 -1.6
Ever had hysterectomy (womb removed) 0.4 0.5 2.7 1.6 0.0 -0.2 0.1 -0.8 0.8 -0.5 0.2 -0.7 -0.1
Systolic blood pressure, automated reading 0.3 1.0 4.6 2.2 0.0 -0.2 -0.1 -0.9 1.3 -0.2 0.1 -0.6 1.4
Eye problems/disorders: Diabetes related eye disease 1.4 1.6 10.3 3.2 0.0 0.6 -0.4 1.0 -0.6 0.2 -0.9 1.2 1.2
Angina 0.5 0.7 3.0 1.5 0.0 0.8 -1.7 -0.9 -0.1 -0.4 -0.2 0.2 0.5
Medication for hormone replacement therapy 0.8 0.9 2.0 -0.1 0.0 -0.1 1.0 1.4 -1.4 1.3 0.2 1.4 0.6
Vitamin and mineral supplements 0.3 0.4 1.2 -0.3 0.0 -1.1 -0.6 0.8 0.1 0.5 0.7 -0.5 -0.7
Supplements: Zinc 0.8 0.9 2.6 0.3 0.0 1.4 -0.8 1.6 -0.6 0.2 -1.2 1.1 0.7
Medication: Co-codamol 0.3 0.3 2.2 0.4 0.0 0.5 1.5 0.3 0.5 0.3 -0.2 -0.1 0.6
Medication: Metformin 0.6 0.8 2.2 1.2 0.0 0.8 1.5 0.5 -0.5 -0.3 -1.3 1.2 0.6
Diabetes (father) 1.3 1.6 5.1 1.6 0.0 0.4 -0.5 1.8 -1.7 2.2 0.9 1.1 -0.2
Diabetes (mother) 0.5 0.7 3.1 1.8 0.0 -0.2 0.9 -0.3 0.4 0.1 -0.4 0.4 1.5
Severe depression (siblings) 1.3 1.5 4.5 -0.6 0.0 -1.9 2.1 0.4 -0.6 1.6 1.8 0.1 -0.1
Pack years adult smoking proportion 1.3 2.1 9.9 0.2 0.0 3.1 -0.9 -0.2 -0.3 -0.9 -2.2 1.4 1.5
Impedance of leg (right) 0.8 4.0 12.7 2.8 0.0 0.7 -1.9 2.7 -0.5 1.0 -1.5 2.2 3.6
Leg fat-free mass (left) 1.0 5.3 23.2 -4.8 0.0 0.6 1.2 -2.4 1.7 -2.4 -0.5 -2.2 -2.8
Trunk fat percentage 0.4 1.5 4.2 -0.8 0.0 1.0 1.1 -1.9 1.4 -1.1 -2.0 -0.1 0.9
Hand grip strength (right) 1.6 4.3 9.1 -3.0 0.0 -1.6 2.3 -2.2 1.5 -0.6 2.1 -2.9 -2.5
Townsend deprivation index at recruitment 0.4 0.6 1.9 -0.1 0.0 1.2 -1.1 -0.4 0.5 -1.4 -0.7 -0.4 -0.4
Current tobacco smoking 0.8 1.4 4.2 1.8 0.0 0.4 -0.2 0.1 -1.3 1.0 -1.0 2.1 1.6
Average weekly fortified wine intake 0.3 0.4 1.4 0.6 0.0 0.5 0.5 0.6 0.2 -0.2 -0.9 0.5 1.2
Maternal smoking around birth 1.3 1.9 9.5 -0.1 0.0 0.7 -0.3 -3.1 1.8 -1.8 -0.9 -1.3 -0.4
Fed-up feelings 0.3 0.5 1.9 0.4 0.0 1.4 -0.4 -0.3 -0.7 -0.1 -1.0 1.1 0.4
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.3 0.8 -0.3 0.0 -0.4 0.4 -0.2 -0.9 0.7 -0.0 0.9 -0.0
Relative age voice broke 0.7 1.1 2.8 -0.1 0.0 -1.5 1.7 1.3 0.3 1.3 1.5 -0.6 -0.4
Taking other prescription medications 0.8 1.2 2.9 1.1 0.0 0.8 1.1 0.8 -1.1 1.6 -0.5 1.7 1.3
Age when periods started (menarche) 0.9 2.2 7.6 1.4 0.0 0.3 -0.8 2.8 -2.0 2.0 0.8 1.6 0.6
Bilateral oophorectomy (both ovaries removed) 0.7 0.8 1.9 0.1 0.0 1.4 1.1 -0.9 -1.0 -0.5 -1.2 1.2 0.3
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.8 4.2 -0.6 0.0 0.3 -0.4 -0.7 1.0 -1.0 -2.0 0.1 0.5
Tinnitus: Yes, but not now, but have in the past 0.5 0.6 1.9 0.6 0.0 0.0 0.3 0.3 -1.1 1.4 1.1 0.8 0.5
Qualifications: CSEs or equivalent 0.7 0.9 2.7 0.7 0.0 1.6 -1.2 -0.3 -0.1 -0.5 -1.7 1.0 0.9
Serious illness, injury or assault to yourself 0.8 0.9 2.7 0.1 0.0 1.6 -0.4 1.2 -1.1 0.2 -0.8 1.5 1.1
High blood pressure 0.1 0.3 1.3 0.0 0.0 1.1 0.2 -0.6 0.2 -0.4 -0.7 0.3 0.7
Hayfever, allergic rhinitis or eczema 1.0 2.3 6.0 1.9 0.0 0.3 0.1 2.4 -1.4 1.9 -0.3 1.9 1.9
Multivitamins +/- minerals 0.4 0.6 3.4 0.7 0.0 0.3 0.1 -1.8 0.3 -0.8 -0.8 0.2 0.6
Stomach or abdominal pain in last month 0.7 0.9 4.3 0.4 0.0 -0.7 -0.0 0.3 -1.2 2.1 1.4 0.9 0.3
Supplements: Glucosamine 0.2 0.2 0.6 -0.4 0.0 -0.6 -0.8 -0.2 0.6 -0.4 -0.3 -0.6 -0.1
Diverticular disease/diverticulitis (self-reported) 1.5 1.8 6.5 -0.8 0.0 -0.1 -0.7 -0.9 1.9 -2.5 -0.7 -1.9 -1.5
Medication: Atenolol 0.4 0.4 1.3 -0.5 0.0 1.2 0.7 0.2 -1.2 -0.2 -0.3 0.9 -0.3
Medication: Levothyroxine sodium 0.1 0.2 0.7 -0.6 0.0 -0.4 0.9 0.3 0.3 0.7 0.2 -0.2 0.1
Sitting height 0.4 3.0 15.5 -3.9 0.0 0.2 1.6 -1.2 1.3 -2.1 -1.1 -1.3 -1.3
Chronic bronchitis/emphysema (father) 1.5 1.8 8.7 -2.9 0.0 -0.4 -1.7 -0.4 1.1 0.1 0.8 -1.5 -1.3
High blood pressure (mother) 1.0 1.3 2.9 1.5 0.0 0.0 1.6 1.7 -1.3 1.1 0.3 1.3 1.0
Body mass index (BMI) 0.3 1.1 5.2 -0.6 0.0 1.2 1.2 -2.3 0.7 -0.9 -0.7 -0.5 -0.6
Impedance of leg (left) 0.8 3.9 13.6 3.0 0.0 0.1 -1.4 2.4 -0.7 1.5 -1.1 2.2 3.7
Leg predicted mass (left) 1.0 5.3 23.4 -4.8 0.0 0.5 1.2 -2.5 1.7 -2.3 -0.5 -2.2 -2.9
Trunk fat mass 0.5 2.3 5.9 -1.9 0.0 0.9 1.5 -2.4 1.7 -1.8 -1.9 -0.8 -0.1
Waist circumference 0.2 0.6 2.0 -1.1 0.0 0.6 1.0 -1.4 0.6 -0.5 -0.3 -0.6 -0.5
Number of incorrect matches in round 0.1 0.2 1.8 0.4 0.0 -0.4 -0.2 -1.4 0.3 -0.2 -0.2 0.0 0.4
Past tobacco smoking 0.4 0.7 3.0 1.7 0.0 -0.7 -0.3 -1.0 0.6 -1.2 -0.3 -0.7 -0.5
Alcohol usually taken with meals 0.5 0.9 2.6 1.6 0.0 0.3 1.2 0.5 -1.2 0.7 0.2 1.2 0.9
Nervous feelings 0.9 1.7 5.9 -1.8 0.0 1.3 2.4 0.8 -1.4 1.3 0.2 1.1 -0.1
Frequency of tenseness / restlessness in last 2 weeks 2.3 3.6 10.2 0.8 0.0 -0.9 1.2 1.5 -2.9 3.2 3.1 1.1 -1.1
Hearing difficulty/problems with background noise 1.3 2.0 5.7 0.2 0.0 0.8 1.1 1.3 -1.6 2.0 -0.5 2.4 2.1
Hair/balding pattern: Pattern 2 0.7 0.9 5.1 -2.3 0.0 0.4 0.6 -1.4 0.7 -0.5 -0.4 -0.5 -0.7
Had menopause 2.6 3.3 12.0 -0.6 0.0 -3.5 1.1 0.4 -0.4 1.8 3.1 -1.3 -2.0
Had other major operations 1.8 2.2 9.3 -0.5 0.0 -2.0 0.4 -0.7 -0.2 1.2 3.1 -1.5 -2.0
Forced vital capacity (FVC) 0.2 0.6 2.4 -0.2 0.0 0.2 0.7 0.2 0.8 -0.8 -1.5 0.3 1.4
Heel bone mineral density (BMD) T-score, automated (right) 0.4 1.0 5.5 -0.5 0.0 0.8 -0.4 -0.7 0.9 -1.0 -2.3 0.5 1.0
Ever unenthusiastic/disinterested for a whole week 0.5 0.6 2.6 -1.6 0.0 -1.4 -0.2 0.5 0.1 0.2 0.3 -0.5 -1.0
Qualifications: None of the above 0.8 1.7 6.1 -1.1 0.0 0.2 -2.5 -0.6 0.2 -0.1 1.7 -1.3 -2.0
Financial difficulties in last 2 years 0.2 0.3 1.0 -1.0 0.0 1.0 0.6 0.1 -0.7 -0.1 0.3 0.2 -0.5
Mouth/teeth dental problems 0.5 0.7 2.8 0.5 0.0 0.5 -0.2 -0.1 1.0 -1.7 -1.7 -0.3 0.4
Heart attack 0.6 0.8 3.5 -1.3 0.0 0.1 -1.9 -1.1 0.4 -0.5 -0.2 -0.6 -1.1
Allergy 1.0 2.2 7.6 -1.2 0.0 -0.2 0.5 -2.8 1.7 -2.4 -0.7 -1.6 -1.1
Pain all over the body in last month 1.1 1.2 4.4 2.1 0.0 -0.8 0.9 0.5 -0.8 1.3 0.4 1.1 1.4
Diabetes (self-reported) 1.3 2.0 6.3 2.5 0.0 1.7 -0.0 1.3 -1.5 0.5 -1.0 2.0 1.2
Hayfever/allergic rhinitis (self-reported) 0.6 0.8 2.5 1.5 0.0 -0.7 0.0 0.3 -0.1 1.6 1.5 0.0 0.8
Medication: Ramipril 0.8 1.1 3.9 -1.3 0.0 0.3 0.2 -1.0 1.6 -0.9 -2.0 -0.3 0.6
Medication: Simvastatin 0.1 0.2 0.4 0.6 0.0 0.1 0.6 -0.2 0.5 -0.4 -0.3 -0.5 -0.1
Fluid intelligence score 0.3 0.7 4.2 -0.1 0.0 -0.6 0.7 2.1 -0.3 0.8 0.8 -0.1 -0.5
Illnesses of siblings 0.2 0.2 0.9 0.1 0.0 0.3 0.5 0.4 -0.8 -0.3 0.3 0.3 -1.0
Neuroticism score 0.3 0.6 2.4 -1.4 0.0 1.5 0.7 -0.4 -0.5 -0.1 -0.5 0.6 -0.2
Weight 0.7 3.5 10.2 -3.2 0.0 0.7 1.7 -2.6 1.9 -2.2 -1.1 -1.7 -1.5
Impedance of arm (right) 0.6 2.7 11.0 -0.3 0.0 1.1 -1.7 0.5 1.2 -1.1 -3.3 1.1 2.7
Arm fat percentage (right) 0.4 1.6 4.4 -0.7 0.0 1.5 1.4 -2.1 1.1 -1.1 -2.0 0.0 0.7
Trunk fat-free mass 0.8 4.6 18.1 -4.3 0.0 0.2 1.5 -2.1 1.2 -2.6 -0.4 -2.1 -3.0
Hip circumference 0.4 1.9 5.7 -2.4 0.0 0.0 0.5 -2.1 1.1 -1.1 0.1 -1.6 -1.8
Time employed in main current job 0.7 0.8 4.5 -1.1 0.0 -0.5 2.1 0.1 -0.5 1.2 0.3 0.6 0.1
Alcohol intake versus 10 years previously 0.1 0.2 0.7 0.2 0.0 -0.2 -0.3 -0.3 0.8 -0.6 -0.7 -0.2 0.6
Father’s age at death 1.1 1.4 5.1 -0.3 0.0 -2.3 1.0 0.8 -0.3 1.3 2.0 -0.6 -1.2
Worrier / anxious feelings 0.1 0.3 1.3 -0.4 0.0 1.1 0.9 0.2 -0.3 0.1 -0.1 0.3 0.1
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.2 0.5 0.4 0.0 0.2 0.7 -0.6 -0.3 0.7 0.6 0.5 0.4
Falls in the last year 0.3 0.4 1.3 0.5 0.0 0.7 -1.1 -0.6 -0.2 -0.9 -0.7 0.0 -0.4
Hair/balding pattern: Pattern 3 0.6 0.8 4.7 2.2 0.0 -0.4 0.3 -1.0 0.8 -1.1 -0.7 -0.4 0.3
Number of live births 2.2 3.1 8.3 -0.2 0.0 -1.7 -2.1 -0.4 1.0 0.5 2.9 -2.6 -2.6
Forced expiratory volume in 1-second (FEV1) 0.3 0.9 3.7 0.2 0.0 0.3 1.3 0.0 0.6 -0.3 -1.6 0.7 1.9
Pulse rate 0.1 0.2 0.6 0.2 0.0 0.1 0.6 0.8 0.3 0.6 0.4 -0.1 0.3
Happiness 0.7 0.8 3.0 -1.2 0.0 1.7 0.3 -0.1 -1.1 -0.3 -1.1 1.1 -0.2
Noisy workplace 1.0 1.2 4.4 -2.1 0.0 -0.9 1.1 -1.2 0.7 -0.3 0.9 -1.1 -1.3
Qualifications: A levels/AS levels or equivalent 0.8 1.8 6.6 1.8 0.0 0.6 -0.3 -0.5 0.6 -1.1 -2.2 1.0 2.6
Serious illness, injury or assault of a close relative in last 2 years 0.9 1.0 4.3 -2.1 0.0 -0.4 1.2 -0.6 -0.8 1.1 1.3 0.1 -0.6
Mouth/teeth dental problems: Dentures 0.9 1.5 3.8 -1.2 0.0 -0.1 0.6 -0.9 -1.8 1.7 2.0 0.3 -1.4
Asthma 0.6 1.2 3.9 1.0 0.0 -0.3 -0.8 2.0 -1.3 1.7 1.0 0.9 0.2
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.2 0.5 -0.6 0.0 -0.6 0.6 0.2 -0.5 0.1 -0.6 0.7 0.2
Medication: Cholesterol lowering 0.2 0.4 0.8 0.7 0.0 0.7 0.4 -0.7 -0.5 -0.3 -0.9 0.8 0.5
Depression (self-reported) 0.5 0.5 2.3 0.2 0.0 1.5 -0.6 -0.1 -1.3 0.1 0.8 0.4 -0.6
Medication: Lansoprazole 1.0 1.2 3.8 1.0 0.0 0.4 -0.4 1.0 -1.7 1.9 0.6 1.4 0.4
Prospective memory result 0.6 0.8 3.1 0.2 0.0 0.4 0.1 -0.9 0.8 -0.7 -1.8 0.6 1.5
Lung cancer (father) 0.9 1.0 3.4 0.1 0.0 -0.1 -0.1 1.4 -1.0 1.0 1.9 -0.4 -1.6
Illnesses of mother 2.1 2.6 13.7 -3.7 0.0 1.8 -1.1 -0.5 0.5 -1.9 -0.7 -0.9 -1.7
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 1.1 4.6 1.0 0.0 -0.2 1.6 0.8 0.3 0.7 -1.0 0.9 2.1
Pulse wave Arterial Stiffness index 0.1 0.1 0.7 0.0 0.0 0.1 0.8 0.1 -0.5 0.1 -0.4 0.4 0.2
Impedance of arm (left) 0.3 1.4 4.8 -0.8 0.0 0.1 -1.5 0.0 1.4 -0.8 -2.2 0.3 1.8
Arm fat mass (right) 0.5 2.0 5.9 -1.4 0.0 1.3 1.7 -2.4 1.3 -1.6 -1.7 -0.6 -0.1
Trunk predicted mass 0.8 4.8 19.2 -4.4 0.0 0.2 1.5 -2.2 1.3 -2.6 -0.4 -2.2 -3.0
Standing height 0.7 7.1 36.7 -6.1 0.0 -0.6 0.8 -1.4 2.8 -3.2 -1.6 -2.6 -2.0
Length of working week for main job 0.6 0.6 1.6 -0.8 0.0 -1.1 -1.3 -0.6 0.6 0.0 0.9 -0.9 -0.7
Exposure to tobacco smoke at home 0.9 1.0 4.5 2.1 0.0 1.1 -1.3 0.4 -0.7 0.6 -0.5 0.9 0.9
Breastfed as a baby 0.5 0.7 2.6 -1.0 0.0 0.1 0.4 -0.2 0.5 -0.0 -1.6 0.6 1.5
Tense / ‘highly strung’ 0.2 0.4 2.0 -0.5 0.0 0.1 0.2 0.3 -0.0 1.4 1.2 -0.2 -0.2
Seen doctor (GP) for nerves, anxiety, tension or depression 0.4 0.6 2.1 -0.5 0.0 -0.1 1.2 0.1 -1.0 1.4 0.2 1.0 0.6
Hair/balding pattern: Pattern 4 0.6 1.3 5.8 -0.0 0.0 -1.1 -0.9 1.2 -0.7 1.6 2.4 -0.5 -1.0
Birth weight of first child 0.9 1.7 9.5 -0.8 0.0 3.1 0.1 -0.4 -0.2 -1.5 -1.9 0.8 0.5
Peak expiratory flow (PEF) 0.3 0.8 4.6 -0.8 0.0 -0.8 2.1 0.2 0.9 0.1 -0.6 -0.1 1.0
Pulse wave reflection index 0.4 0.5 1.4 -1.1 0.0 0.6 -0.8 -0.4 0.2 -1.2 -1.0 -0.2 -0.4
Ever highly irritable/argumentative for 2 days 0.1 0.1 0.6 -0.8 0.0 0.2 -0.2 -0.0 0.2 -0.1 0.1 -0.3 -0.3
Loud music exposure frequency 0.7 0.8 1.7 -0.7 0.0 -0.6 -1.0 1.2 -1.1 1.3 0.7 0.4 -1.0
Qualifications: O levels/GCSEs or equivalent 1.0 1.6 7.7 2.8 0.0 1.0 0.9 0.3 -1.2 0.0 -0.9 1.5 1.3
Mouth/teeth dental problems: Bleeding gums 1.0 1.3 4.0 1.3 0.0 -1.4 -0.3 1.1 -0.5 2.0 2.0 0.2 0.3
Blood clot in the leg (DVT) 0.8 1.0 2.2 0.7 0.0 1.4 -1.5 0.6 -0.9 0.2 -1.2 1.4 0.8
Medication: Paracetamol 0.1 0.2 0.9 -0.9 0.0 0.9 -0.6 -0.4 0.2 -0.2 -0.2 0.0 0.0
Headache pain in last month 0.2 0.4 0.9 -0.9 0.0 -0.6 0.4 -0.3 1.0 0.0 0.1 -0.8 -0.8
Medication for cholesterol, blood pressure or diabetes 0.4 0.7 1.7 0.8 0.0 -0.9 -0.9 -0.6 1.1 -0.6 0.6 -1.3 -0.4
Glaucoma (self-reported) 0.5 0.6 1.7 1.3 0.0 0.2 1.1 1.2 0.1 0.4 -0.6 0.4 0.9
Gout (self-reported) 0.8 1.1 4.2 -2.1 0.0 -1.3 -0.7 -0.4 0.4 0.5 0.9 -1.1 -1.6
Hypothyroidism/myxoedema (self-reported) 0.3 0.5 1.9 -0.8 0.0 -0.9 0.6 -0.4 1.4 0.4 -0.0 -1.0 -0.0
Medication: Amlodipine 0.3 0.4 2.2 -0.7 0.0 -0.0 1.5 0.1 -0.8 0.5 0.4 0.4 -0.4
Medication: Ventolin 100micrograms inhaler 0.3 0.4 1.5 1.0 0.0 -0.1 -0.0 1.2 -0.5 0.5 -0.3 0.6 0.4
Birth weight 1.6 3.5 16.5 -4.1 0.0 -1.7 1.2 -1.1 1.5 -1.5 0.3 -2.1 -2.0
Chronic bronchitis/emphysema (mother) 0.5 0.6 3.4 -1.8 0.0 -0.4 -0.6 -0.2 -0.0 -0.1 0.6 -0.5 -1.3
High blood pressure (siblings) 0.2 0.3 2.3 -0.3 0.0 -0.1 -1.5 0.1 0.4 0.3 -0.3 -0.2 0.3
Forced vital capacity (FVC), Best measure 0.2 0.8 3.7 0.8 0.0 -0.3 1.0 1.0 0.5 0.6 -0.7 0.6 1.9
Body fat percentage 0.3 1.0 3.2 -0.6 0.0 0.9 1.1 -1.8 1.2 -0.9 -1.5 -0.2 0.5
Leg fat percentage (right) 0.1 0.5 1.2 0.6 0.0 0.7 0.9 -1.1 0.8 -0.5 -0.8 -0.3 0.4
Arm fat-free mass (right) 0.7 3.8 11.5 -3.4 0.0 -0.4 1.4 -2.1 1.3 -1.9 0.5 -2.3 -3.0
Exposure to tobacco smoke outside home 1.3 1.7 6.1 -0.5 0.0 0.7 -0.7 -2.5 0.6 -1.9 -2.3 0.1 0.2
Comparative body size at age 10 0.1 0.2 1.7 -0.3 0.0 -0.1 0.3 -1.3 0.2 -0.2 0.2 -0.3 -0.1
Number of full brothers 1.4 1.7 5.6 -2.4 0.0 -0.8 -0.8 -1.2 1.8 -0.9 0.9 -1.9 -0.7
Worry too long after embarrassment 0.3 0.4 1.1 -1.1 0.0 0.5 0.5 0.6 -0.5 -0.2 -1.1 0.8 0.4
Seen a psychiatrist for nerves, anxiety, tension or depression 0.1 0.1 0.4 -0.0 0.0 -0.0 -0.5 -0.1 0.6 0.3 -0.3 -0.2 0.6
Wheeze or whistling in the chest in last year 0.6 1.2 2.7 0.0 0.0 1.2 -1.2 1.4 -1.4 1.3 1.6 0.5 -0.6
Number of children fathered 0.3 0.3 1.0 -0.1 0.0 0.0 0.7 0.5 -0.5 0.5 1.0 -0.3 -0.9
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.2 1.2 -0.5 0.0 -0.2 -0.2 -1.1 0.6 -0.2 -0.1 -0.4 0.2
Age at first live birth 1.0 1.7 6.4 0.6 0.0 -1.7 2.2 2.5 -0.1 1.4 0.8 0.2 0.4
Pulse wave peak to peak time 0.1 0.1 0.6 -0.2 0.0 -0.0 -0.8 -0.1 0.4 -0.1 0.3 -0.3 -0.1
Health satisfaction 0.6 0.8 2.1 0.8 0.0 1.4 0.8 0.3 -0.5 -0.2 -1.3 1.2 1.3
Shortness of breath walking on level ground 0.2 0.2 0.6 0.7 0.0 0.6 0.6 0.3 -0.5 0.2 0.1 0.5 0.2
Qualifications: College or University degree 0.4 1.1 4.2 0.3 0.0 -1.4 1.3 0.0 1.3 -0.5 -1.3 0.0 2.0
Eye problems/disorders: None of the above 0.5 0.6 1.7 -0.8 0.0 -0.6 0.7 1.3 -0.9 1.0 0.3 0.7 -0.2
Mouth/teeth dental problems: Loose teeth 0.9 1.0 3.0 0.5 0.0 0.2 1.6 0.7 -1.7 1.2 1.2 1.0 -0.5
Emphysema/chronic bronchitis 0.7 0.8 2.3 -1.5 0.0 -0.4 0.1 1.1 0.0 0.5 1.5 -0.7 -0.8
Medication for pain relief, constipation, heartburn 0.1 0.2 0.5 0.5 0.0 -0.6 -0.0 0.1 0.7 0.3 0.6 -0.6 0.2
Neck or shoulder pain in last month 0.8 1.1 2.5 1.0 0.0 1.6 -0.2 1.1 -0.8 -0.2 -1.3 1.6 1.3
Medication: Blood pressure 0.8 1.5 3.8 -0.5 0.0 0.9 1.2 1.8 -2.0 1.4 0.1 1.7 0.3
Angina (self-reported) 0.6 0.7 3.4 1.3 0.0 0.6 -1.9 -1.1 0.1 -0.6 -0.2 -0.1 0.2
Migraine (self-reported) 0.7 0.9 2.3 -0.5 0.0 -0.9 1.3 -0.4 -0.9 0.8 1.5 -0.2 -1.5
Medication: Ibuprofen 0.3 0.4 1.3 -0.4 0.0 -0.3 0.6 0.4 -1.0 0.1 -0.8 1.1 0.5
Medication: Allopurinol 0.8 1.1 3.4 -1.8 0.0 -1.2 -0.4 -1.3 1.1 -0.1 0.2 -1.1 -1.1
Medication: Omeprazole 0.3 0.4 1.8 -0.2 0.0 -0.6 -0.2 0.4 -0.8 0.2 0.8 0.0 -1.3
Medication: Seretide 50 evohaler 0.1 0.1 0.3 0.1 0.0 0.2 -0.4 0.3 0.1 -0.2 0.1 -0.3 -0.5
Mean time to correctly identify matches 0.4 0.7 2.9 0.1 0.0 -0.3 1.6 -1.7 0.3 -0.5 0.8 -0.6 -0.6
Heart disease (mother) 0.4 0.5 2.8 1.7 0.0 0.4 -0.8 0.8 0.1 0.1 -0.4 0.4 0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.6 0.7 2.5 0.5 0.0 -1.6 -0.2 0.4 0.2 0.1 1.3 -1.0 -1.3
Whole body fat mass 0.4 1.8 5.7 -1.6 0.0 0.8 1.3 -2.4 1.6 -1.5 -1.4 -0.9 -0.4
Leg fat mass (right) 0.4 1.4 4.0 -1.3 0.0 0.8 1.4 -2.0 1.3 -1.3 -0.9 -1.0 -0.7
Arm predicted mass (right) 0.7 3.5 12.3 -3.5 0.0 -0.6 1.5 -1.6 0.9 -1.4 0.9 -2.1 -3.1
Pulse rate, automated reading 0.2 0.8 2.3 0.8 0.0 -0.3 0.9 1.4 -0.2 1.5 1.2 0.4 0.8
Alcohol intake frequency. 0.9 2.0 3.9 2.0 0.0 1.8 1.1 1.5 -1.8 0.7 -0.5 2.0 1.1
Comparative height size at age 10 1.7 9.4 27.8 -5.3 0.0 -1.3 1.2 -3.4 4.1 -4.0 -2.0 -3.4 -1.8
Number of full sisters 0.8 1.0 2.2 0.7 0.0 -0.7 -0.4 1.1 -1.4 1.4 1.5 0.3 -1.1
Suffer from ‘nerves’ 0.3 0.5 2.0 -0.9 0.0 0.5 1.4 -0.7 -0.7 0.4 -0.3 0.7 0.2
Overall health rating 0.5 1.0 3.6 1.3 0.0 1.9 -0.4 0.8 -1.1 0.5 -0.2 1.3 0.7
Chest pain or discomfort 0.2 0.3 1.1 0.8 0.0 -0.3 -0.4 0.5 -0.7 0.8 1.1 0.3 -0.1
Had major operations 0.4 0.5 1.9 -0.5 0.0 1.4 0.1 0.6 -0.9 -0.5 -0.5 0.8 0.6
Age at last live birth 1.5 2.2 7.1 1.3 0.0 -2.1 1.5 1.0 0.8 1.1 2.7 -1.7 -1.0
Family relationship satisfaction 0.3 0.4 1.5 -0.4 0.0 1.2 0.4 -0.3 -0.1 -0.7 -1.1 0.5 0.4
Leg pain on walking 1.5 1.8 5.2 -0.7 0.0 -1.1 -0.9 -2.1 2.3 -1.4 -0.4 -1.9 -0.7
Qualifications: NVQ or HND or HNC or equivalent 0.9 1.1 3.0 0.3 0.0 -0.4 0.1 1.5 -1.4 1.7 1.5 0.6 -0.8
Commuting to job workplace: Car/motor vehicle 0.8 0.9 3.3 -0.3 0.0 -0.9 1.8 0.9 -0.7 1.3 1.1 0.3 -0.1
Illness, injury, bereavement, stress in last 2 years 0.2 0.3 1.4 0.3 0.0 0.2 1.2 -0.0 0.3 -0.6 -0.9 0.1 0.2
Medication: Aspirin 1.2 1.6 5.4 0.6 0.0 1.5 0.5 1.1 -0.8 -0.7 -2.3 1.7 1.4
Supplements: Vitamin C 0.6 0.7 2.2 -1.0 0.0 1.5 0.4 1.1 -1.2 -0.6 -0.2 0.7 -0.4
Knee pain experienced in last month 0.3 0.5 1.9 -0.4 0.0 1.1 -1.4 -0.0 -0.6 -0.8 -0.6 0.3 -0.4
Hypertension (Self-reported) 0.1 0.2 0.4 -0.2 0.0 0.5 0.6 -0.7 0.3 -0.1 -0.2 0.0 0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.4 1.6 4.5 -0.8 0.0 -0.0 0.2 1.8 -2.1 2.0 1.2 1.3 -0.5
Illnesses of father: Heart disease 2.0 2.8 10.2 0.7 0.0 0.9 2.3 0.4 -0.1 0.2 -2.6 2.0 3.2
Illnesses of siblings: Diabetes 0.2 0.2 0.9 0.9 0.0 -0.2 0.6 -0.2 -0.1 0.3 0.4 0.2 0.7
Smoking status: Previous 0.5 0.8 6.3 -2.5 0.0 0.3 0.1 0.4 -0.2 0.8 0.7 0.0 -0.1
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.9 5.1 -2.3 0.0 1.3 0.4 0.8 0.2 -0.4 -0.9 0.2 0.3
Whole body fat-free mass 0.9 5.2 21.9 -4.7 0.0 0.2 1.4 -2.3 1.4 -2.5 -0.3 -2.2 -3.1
Leg fat-free mass (right) 1.0 5.5 23.6 -4.9 0.0 0.1 1.4 -2.7 1.7 -2.2 -0.1 -2.4 -3.1
Arm fat percentage (left) 0.4 1.5 5.8 -0.7 0.0 1.0 1.4 -2.4 1.2 -1.1 -1.6 -0.3 0.2
Average weekly red wine intake 0.8 1.2 6.2 2.5 0.0 0.2 0.6 0.6 -1.3 1.0 1.4 0.6 -0.0
Handedness (chirality/laterality): Left-handed 0.5 0.6 2.6 -0.5 0.0 -1.3 1.6 -0.1 1.0 0.3 0.5 -0.6 0.4
Mood swings 0.3 0.6 2.9 0.0 0.0 0.2 1.7 -1.7 0.5 -0.4 -0.3 -0.2 -0.0
Loneliness, isolation 0.9 1.2 3.4 -1.0 0.0 1.3 -1.4 -1.8 0.4 -1.3 -0.3 -0.7 -1.3
Long-standing illness, disability or infirmity 0.6 0.9 3.0 0.4 0.0 1.7 -0.0 0.7 -1.3 0.6 -0.4 1.6 0.9
Ever had bowel cancer screening 0.4 0.5 2.3 0.8 0.0 1.0 0.3 -1.5 -0.8 0.2 0.3 0.4 -0.1
Diabetes diagnosed by doctor 1.1 1.8 4.5 2.1 0.0 1.9 0.7 1.5 -1.2 -0.1 -1.4 1.7 1.0
Ever had stillbirth, spontaneous miscarriage or termination 0.2 0.2 0.7 0.4 0.0 -0.5 -0.1 -0.8 0.0 0.8 0.5 -0.1 -0.1
Friendships satisfaction 0.4 0.5 2.3 -1.5 0.0 0.4 -0.7 -0.2 0.4 -0.9 -0.1 -0.7 -0.6
Qualifications: nursing, teaching 0.7 1.1 6.0 0.1 0.0 0.7 2.4 1.6 -0.3 0.1 -1.0 0.8 0.8
Commuting to job workplace: Walk 0.7 0.7 2.7 1.4 0.0 0.4 -1.7 -1.4 -0.2 -0.6 -0.4 0.2 0.4
Eye problems/disorders: Cataract 0.9 1.1 4.2 -0.7 0.0 -0.1 -2.0 -1.9 0.8 -0.8 0.3 -1.0 -0.2
Mouth/teeth dental problems: Mouth ulcers 1.1 1.7 9.2 -0.3 0.0 1.0 0.3 -0.1 1.0 -0.8 -2.1 1.0 3.0
Medication for cholesterol 0.2 0.3 0.8 -0.6 0.0 -0.6 -0.9 0.8 -0.5 0.5 0.4 0.1 -0.8
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.5 1.7 4.8 -1.5 0.0 0.5 1.1 2.1 -2.2 1.0 1.0 1.1 -0.9
Back pain experienced in last month 0.4 0.7 1.8 -0.8 0.0 -0.4 -1.1 -0.4 1.0 -0.2 0.9 -1.3 -0.9
Mineral and other dietary supplements 0.4 0.5 1.6 0.6 0.0 -0.5 -1.1 0.5 -0.4 1.1 1.3 -0.1 -0.0
Breast cancer (self-reported) 0.2 0.3 0.7 -0.5 0.0 -0.1 0.2 -0.9 0.6 -0.7 -0.7 -0.2 0.2
Asthma (self-reported) 0.6 1.3 3.9 0.9 0.0 -0.5 -0.9 2.0 -1.5 1.7 1.0 0.9 -0.0
Osteoporosis (self-reported) 0.5 0.7 2.4 -0.0 0.0 1.5 -0.3 0.3 -0.5 -0.9 -1.3 0.9 0.8
Osteoarthritis (self-reported) 0.2 0.2 1.5 1.2 0.0 0.5 -0.1 0.4 -0.3 0.3 -0.3 0.3 0.3
Medication: Aspirin 0.7 0.9 3.0 0.4 0.0 0.9 0.2 1.4 -0.7 -0.4 -1.7 1.3 1.0
Medication: Gliclazide 0.6 0.7 2.7 0.4 0.0 0.6 1.3 0.1 0.5 -1.2 -1.6 -0.0 -0.3
Illnesses of father: None of the above (group 1) 1.5 1.8 5.5 -1.4 0.0 -1.3 -1.4 -0.1 0.9 -1.1 1.1 -1.9 -2.3
Smoking status: Current 1.0 1.7 5.4 2.3 0.0 0.4 -0.4 0.5 -1.6 1.4 -0.4 2.0 1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 1.0 2.5 1.4 0.0 -0.4 1.3 1.0 0.2 -0.2 -1.3 0.7 1.6
Whole body water mass 0.9 5.2 21.3 -4.6 0.0 0.1 1.6 -2.2 1.4 -2.4 -0.2 -2.3 -3.1
Leg predicted mass (right) 1.0 5.4 23.0 -4.8 0.0 0.1 1.4 -2.6 1.7 -2.1 -0.1 -2.3 -3.0
Arm fat mass (left) 0.5 2.0 6.8 -1.6 0.0 1.1 1.6 -2.6 1.3 -1.5 -1.4 -0.8 -0.5
Number of self-reported non-cancer illnesses 0.2 0.3 1.2 -0.0 0.0 -0.3 0.2 -0.7 0.2 0.9 1.1 -0.6 -0.5
Average weekly champagne plus white wine intake 0.5 0.7 2.5 -0.3 0.0 0.8 -0.1 -1.2 0.8 -1.3 -1.6 -0.0 0.7
Miserableness 0.3 0.5 3.3 1.8 0.0 -0.7 -0.2 -0.6 0.5 0.0 0.4 -0.4 0.2
Guilty feelings 0.6 0.9 5.0 -0.3 0.0 1.4 -2.2 0.1 -0.7 0.1 -0.6 0.6 -0.4
Wears glasses or contact lenses 0.3 0.3 1.1 0.9 0.0 -1.0 0.0 -0.1 -0.4 0.8 0.2 0.2 -0.1
Ever taken oral contraceptive pill 0.3 0.4 0.9 -0.1 0.0 0.3 -0.5 -0.1 0.8 -1.0 -0.9 -0.0 0.9
Hearing aid user 1.3 1.5 5.5 0.7 0.0 1.7 2.3 1.2 -0.9 0.3 -0.9 1.4 1.1
Mother’s age at death 0.7 0.9 4.7 2.2 0.0 -0.6 -0.6 0.7 -1.0 0.8 0.8 0.6 0.2
Financial situation satisfaction 1.1 1.4 3.6 -1.5 0.0 -0.2 1.1 0.4 -1.9 1.6 1.7 0.7 -0.9
Tinnitus: Yes, now most or all of the time 0.9 1.1 3.3 -1.3 0.0 -0.6 0.1 -0.4 1.1 -0.5 1.1 -1.8 -1.7
Commuting to job workplace: Public transport 0.7 0.9 1.8 0.6 0.0 1.2 -1.3 -1.3 0.2 -0.7 -1.0 0.6 1.4
Eye problems/disorders: Glaucoma 0.5 0.5 2.8 0.9 0.0 0.5 0.2 1.7 -0.7 0.6 -0.2 0.7 0.4
Medication: Blood pressure 0.2 0.3 2.1 -0.1 0.0 0.6 0.4 -1.5 0.2 -0.5 0.3 -0.2 0.1
Pain type(s) experienced in last month: Hip pain 0.2 0.3 1.3 0.6 0.0 -1.1 0.7 0.4 0.0 0.4 0.1 -0.0 -0.2
Supplements: Fish oil (including cod liver oil) 0.4 0.5 1.9 -0.1 0.0 0.1 0.2 -1.0 0.8 -1.4 -0.8 -0.7 -0.7
High cholesterol (Self-reported) 0.4 0.8 2.7 0.3 0.0 0.4 0.2 -0.3 1.6 -1.4 -1.3 -0.8 0.7
Medication: Bendroflumethiazide 0.6 0.8 2.7 0.6 0.0 1.6 -0.9 -0.1 -1.2 -0.4 -0.9 1.3 0.8
Medication: Paracetamol 0.3 0.4 1.9 -1.0 0.0 0.5 -1.4 -0.8 0.4 -0.4 -0.2 -0.2 -0.2
Medication: Lisinopril 2.5 3.2 9.5 1.7 0.0 3.1 1.5 2.0 -1.5 -0.7 -1.6 2.2 1.9
Medication: Atorvastatin 1.8 2.2 5.6 2.0 0.0 1.2 0.2 1.4 -2.1 1.1 -0.8 2.4 1.6
Illnesses of father: High blood pressure 2.4 3.0 9.9 3.1 0.0 1.2 -0.2 1.1 -1.8 1.3 -0.7 2.5 2.4
Alcohol drinker status: Never 0.7 0.8 3.3 0.3 0.0 1.0 0.2 1.8 -0.7 0.9 -0.2 1.1 0.9
Ever smoked 0.5 0.8 2.5 -0.9 0.0 0.2 0.1 1.5 -0.6 1.6 0.1 1.1 1.1
Basal metabolic rate 0.8 4.6 18.4 -4.3 0.0 0.4 1.6 -2.4 1.5 -2.3 -0.5 -2.1 -2.7
Leg fat percentage (left) 0.1 0.4 1.5 0.5 0.0 0.4 1.2 -1.2 0.7 -0.2 -0.5 -0.3 0.4
Arm fat-free mass (left) 0.7 3.4 11.6 -3.4 0.0 -0.1 1.6 -1.8 1.4 -1.8 0.1 -2.1 -2.6
Number of operations (self-reported) 0.7 1.1 3.8 -0.1 0.0 -0.2 1.8 0.4 -1.5 1.2 1.9 0.2 -0.5
Average weekly beer plus cider intake 1.5 2.2 4.9 -1.2 0.0 -2.2 -1.9 -1.7 2.0 -0.2 0.3 -1.9 -1.2
Irritability 0.5 0.8 3.8 -0.2 0.0 0.2 1.9 0.7 -1.1 1.1 0.8 0.6 -0.3
Risk taking 1.4 2.0 9.2 3.0 0.0 -1.6 0.4 0.3 0.5 1.4 0.9 0.2 2.2
Ever had prostate specific antigen (PSA) test 0.5 0.6 2.8 0.8 0.0 0.2 -0.1 0.1 -0.6 0.6 -0.4 1.2 1.7
Fractured/broken bones in last 5 years 0.3 0.4 1.2 -0.2 0.0 -0.8 -1.1 -0.8 0.4 -0.8 0.1 -0.6 -0.5
Age started oral contraceptive pill 0.8 1.0 2.8 -0.7 0.0 -1.7 1.1 0.8 0.1 -0.1 1.4 -1.1 -1.2
Diastolic blood pressure, automated reading 0.2 0.5 1.5 -0.0 0.0 -0.1 0.8 -1.2 1.1 -0.6 0.4 -1.0 0.1
Ever depressed for a whole week 0.9 1.1 2.9 -1.1 0.0 -1.7 0.3 -0.2 -0.4 1.4 1.6 -0.6 -1.3
Unable to work because of sickness or disability 0.5 0.6 2.3 1.5 0.0 0.5 -1.5 -0.2 -0.5 0.6 0.5 0.5 0.4
Commuting to job workplace: Cycle 2.1 2.6 7.8 2.8 0.0 1.0 0.9 1.5 -1.0 0.2 -1.3 2.0 2.6
Myopia 0.3 0.4 2.2 1.5 0.0 0.1 -0.9 0.7 -0.3 0.6 -0.2 0.5 0.4
Vascular/heart problems diagnosed by doctor 0.1 0.4 1.4 0.1 0.0 -0.9 -0.1 1.2 -0.6 0.7 0.6 0.2 -0.4
Cholesterol lowering medication 0.5 0.7 3.0 1.7 0.0 0.5 0.3 1.3 0.4 0.5 -0.5 0.2 1.3
Medication: Omeprazole (e.g. Zanprol) 0.5 0.6 1.3 0.9 0.0 -0.6 -0.6 0.9 -1.1 0.9 0.6 0.8 -0.2
Pain experienced in last month 0.4 0.6 1.7 0.1 0.0 0.7 1.0 -0.1 -0.4 -0.2 -1.3 1.1 1.3
Supplements: Calcium 0.5 0.5 2.6 1.6 0.0 0.8 -0.3 0.9 -0.2 0.3 -0.0 0.4 0.8
Basal cell carcinoma (self-reported) 0.3 0.4 1.0 -0.0 0.0 0.5 0.8 -0.8 1.0 -0.4 -0.5 -0.3 1.0
Heart attack/myocardial infarction (self-reported) 0.8 1.1 3.6 -1.1 0.0 -0.2 -1.9 -1.5 0.9 -0.7 -0.3 -1.0 -1.2
Deep venous thrombosis (DVT) (self-reported) 0.6 0.8 2.0 0.6 0.0 1.1 -1.1 0.8 -1.1 0.6 -0.8 1.4 0.5
Heart disease (siblings) 0.1 0.1 0.5 -0.1 0.0 -0.2 0.7 -0.1 0.3 0.1 0.5 -0.2 0.2
Alcohol drinker status: Previous 0.2 0.2 0.8 0.4 0.0 0.6 -0.9 0.2 -0.3 0.2 0.2 0.0 -0.4
Pack years of smoking 1.5 2.1 10.1 -0.3 0.0 3.2 -1.0 -0.1 -0.2 -1.2 -2.3 1.3 1.3
Impedance of whole body 0.4 2.1 8.5 1.1 0.0 0.1 -1.9 1.2 0.9 0.1 -2.0 1.0 2.9
Leg fat mass (left) 0.3 1.3 4.2 -1.2 0.0 0.5 1.7 -2.1 1.2 -1.0 -0.7 -1.0 -0.7
Arm predicted mass (left) 0.5 2.6 10.6 -3.3 0.0 0.2 1.4 -1.5 1.0 -1.6 -0.1 -1.6 -2.2