Hub : Genes

COPG1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Cortex 0.2440 0.0900 0.00360 0.001 NA 0.029 NA 0.028 0.30000 NA 0.05300 NA 0.05700
2 METSIM Adipose 0.0414 0.0184 0.00015 0.018 0.032 0.022 0.033 0.021 0.00079 1.1e-05 0.00026 7.6e-06 0.00032

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 2.6 4.2 7.5 -0.9 2.7
Bipolar Disorder or Schizophrenia 2.5 6.0 12.0 -0.3 3.5
Depressed Affect (Nagel 2018) 1.2 2.4 2.5 1.5 -1.6
Depression (Nagel 2018) 0.2 0.3 0.3 0.6 -0.6
Intelligence (Savage-Jansen 2018) 1.3 4.1 5.2 -1.7 -2.3
Neuroticism (Nagel 2018) 1.3 3.1 3.3 1.7 -1.8
Schizophrenia (2018) 1.2 2.6 5.0 0.3 2.2
Schizophrenia vs Biploar Disorder 0.2 0.2 0.5 0.7 0.1
Worry (Nagel 2018) 1.2 2.5 5.0 2.2 -0.3
Alzheimer’s Disease (in mother) 0.6 0.7 1.2 -1.1 0.4
Alzheimer’s Disease (in father) 1.8 1.9 3.8 1.9 0.1
Alzheimer’s Disease (including proxy) 1.1 1.6 2.9 1.7 0.6
Crohns Disease (2017) 0.2 0.4 0.7 -0.8 -0.4
Irritable Bowel Disease (IBD) 0.0 0.0 0.1 0.3 0.0
Ulcerative Colitis (UC) 0.5 0.8 1.6 1.3 0.3
Major Depression (MDD) 0.0 0.0 0.1 0.1 -0.2
Reaction Time 1.1 2.0 2.6 1.6 -1.2
Verbal and Numeric Reasoning (VNR) 0.2 0.5 0.8 -0.5 -0.9
Breast Cancer 1.5 3.7 6.6 0.9 2.6
Ovarian Cancer 0.3 0.4 0.6 -0.4 0.8
Prostate Cancer 1.0 1.4 1.6 -1.3 -1.1
Age at First Birth 1.2 1.7 3.1 -1.8 -0.5
Bipolar Disorder (2011) 3.6 3.5 6.8 -0.4 2.6
Body Mass Index (BMI) (2010) 0.4 0.6 0.9 -0.5 0.9
Coronary Artery Disease (CAD) 4.2 5.0 10.0 3.2 -0.0
Crohns Disease (2012) 0.4 0.6 1.1 -0.3 1.0
Mean Putamen Volume 1.0 1.1 1.5 0.9 -1.2
Fasting Glucose 1.2 1.4 1.6 1.3 1.1
HbA1C 1.9 2.1 4.1 -0.3 2.0
HDL Cholesterol 0.1 0.1 0.2 0.4 -0.3
LDL Cholesterol 0.8 1.3 2.3 1.5 -0.5
Lupus 0.3 0.4 0.5 -0.7 0.6
Neuroticism (2016) 1.1 1.5 1.8 1.3 -1.1
Primary Biliary Cirrhosis 1.0 1.4 2.6 -0.4 1.6
Rheumatoid Arthritis 1.7 2.3 2.4 1.5 1.5
Schizophrenia (2014) 3.0 6.6 13.0 0.3 3.6
Triglycerides 0.6 0.9 1.1 0.9 1.0
Type 2 Diabetes (T2D) (2012) 2.2 2.6 4.3 2.1 0.9
Ulcerative Colitis 0.4 0.6 0.9 1.0 0.4
Blood Eosinophil Count 1.6 12.5 13.8 -3.7 3.4
Blood Platelet Count 0.2 1.9 3.3 1.8 0.7
Blood Red Count 0.4 4.1 5.2 -2.3 1.7
Blood White Count 0.4 2.9 3.6 1.5 -1.9
Heel T-Score 1.9 15.2 23.8 -2.5 4.9
BMI 0.5 2.6 5.2 -0.2 -2.3
Height 6.9 132.7 148.8 -12.2 -10.8
Waist Hip Ratio (WHR) 10.3 46.3 91.6 9.6 -1.0
Systolic Blood Pressure 0.6 2.9 4.2 2.1 1.2
Smoking Status 1.9 4.5 6.0 1.8 -2.5
Allergy or Eczema 0.1 0.2 0.4 0.1 0.7
Cardiovascular Disease 2.6 8.5 16.2 4.0 0.9
Hypothyroidism (self reported) 0.2 0.4 0.5 -0.7 -0.6
Respiratory disease 0.0 0.1 0.1 0.4 0.1
Type 2 Diabetes (T2D) (2018) 0.8 1.5 2.1 1.5 1.0
Lung FEV1/FVC ratio 0.3 1.7 2.0 1.4 -1.1
Lung FVC 1.0 4.9 9.7 -3.1 -0.1
Neuroticism 2.1 5.1 6.9 2.6 -1.8
Chronotype (morning person) 0.4 0.9 1.7 -0.1 -1.3
Hair Pigment 0.0 1.1 1.9 -1.4 0.6
Tanning 0.0 0.3 0.6 -0.1 -0.8
Hand grip strength (left) 3.5 9.3 13.1 -2.3 -3.6
Number of treatments/medications taken 1.1 1.9 3.2 1.8 0.8
Average weekly spirits intake 0.2 0.2 0.4 -0.6 -0.1
Sensitivity / hurt feelings 0.6 1.0 2.0 -0.1 -1.4
Frequency of depressed mood in last 2 weeks 1.7 2.4 3.7 1.1 -1.9
Hearing difficulty/problems: Yes 2.2 3.4 3.7 -1.9 -1.7
Relative age of first facial hair 0.7 1.5 2.3 1.5 0.8
Other serious medical condition/disability diagnosed by doctor 2.2 2.9 3.2 -1.8 -1.6
Ever used hormone-replacement therapy (HRT) 0.3 0.4 0.5 -0.6 0.7
Ever had hysterectomy (womb removed) 0.4 0.4 0.7 -0.3 0.9
Systolic blood pressure, automated reading 0.2 0.6 1.2 0.0 1.1
Eye problems/disorders: Diabetes related eye disease 0.7 0.7 1.1 -0.6 1.0
Angina 2.4 3.1 6.1 2.5 -0.3
Medication for hormone replacement therapy 1.1 1.3 1.7 -0.9 -1.3
Vitamin and mineral supplements 0.0 0.0 0.0 0.1 -0.2
Supplements: Zinc 1.8 2.0 3.8 -0.5 1.9
Medication: Co-codamol 0.3 0.3 0.7 0.2 -0.8
Medication: Metformin 3.5 4.9 7.7 1.4 2.8
Diabetes (father) 3.0 3.7 4.2 2.0 1.8
Diabetes (mother) 3.5 4.5 8.8 3.0 -0.4
Severe depression (siblings) 2.5 2.7 5.0 2.2 -0.7
Pack years adult smoking proportion 3.1 4.8 6.4 2.5 1.8
Impedance of leg (right) 1.3 6.2 12.3 0.1 3.5
Leg fat-free mass (left) 5.4 28.5 41.2 -4.0 -6.4
Trunk fat percentage 0.8 3.1 4.0 -2.0 -1.4
Hand grip strength (right) 2.6 7.0 11.5 -1.6 -3.4
Townsend deprivation index at recruitment 1.0 1.5 2.4 0.7 -1.6
Current tobacco smoking 0.9 1.5 2.8 1.7 0.4
Average weekly fortified wine intake 1.6 1.8 3.0 -1.7 -0.8
Maternal smoking around birth 1.4 2.0 2.1 1.4 -1.4
Fed-up feelings 1.5 2.6 3.4 1.4 -1.8
Frequency of unenthusiasm / disinterest in last 2 weeks 1.1 1.4 1.6 1.1 -1.3
Relative age voice broke 0.0 0.0 0.1 0.1 0.3
Taking other prescription medications 0.7 1.1 1.9 1.4 0.5
Age when periods started (menarche) 0.4 1.0 1.7 -1.3 0.5
Bilateral oophorectomy (both ovaries removed) 0.2 0.2 0.4 -0.1 -0.6
Heel bone mineral density (BMD) T-score, automated (left) 1.8 4.1 8.1 0.2 2.9
Tinnitus: Yes, but not now, but have in the past 0.1 0.1 0.2 0.5 0.2
Qualifications: CSEs or equivalent 0.9 1.2 2.1 0.5 -1.5
Serious illness, injury or assault to yourself 0.1 0.2 0.3 -0.5 0.3
High blood pressure 1.2 3.4 4.0 2.0 1.7
Hayfever, allergic rhinitis or eczema 0.2 0.5 0.5 -0.7 0.7
Multivitamins +/- minerals 0.5 0.6 1.1 -1.1 -0.2
Stomach or abdominal pain in last month 1.7 2.1 4.0 2.0 -0.5
Supplements: Glucosamine 1.4 1.9 2.9 -1.7 -0.9
Diverticular disease/diverticulitis (self-reported) 2.2 2.6 3.0 -1.4 1.7
Medication: Atenolol 1.4 1.7 3.1 1.8 0.5
Medication: Levothyroxine sodium 0.4 0.7 0.9 0.9 -0.7
Sitting height 5.5 39.0 41.3 -6.4 -6.1
Chronic bronchitis/emphysema (father) 1.0 1.1 1.3 -1.0 -1.1
High blood pressure (mother) 0.3 0.5 0.7 0.5 -0.8
Body mass index (BMI) 0.2 1.0 1.8 -0.4 -1.4
Impedance of leg (left) 1.1 5.4 10.8 0.2 3.3
Leg predicted mass (left) 5.3 28.1 40.4 -4.0 -6.4
Trunk fat mass 2.0 8.7 9.4 -2.8 -3.1
Waist circumference 0.9 3.3 6.4 0.3 -2.5
Number of incorrect matches in round 1.4 2.3 2.3 -1.5 1.5
Past tobacco smoking 2.9 5.4 10.6 -0.4 3.3
Alcohol usually taken with meals 2.8 4.5 9.0 -3.0 -0.1
Nervous feelings 1.0 1.8 3.3 1.8 -0.6
Frequency of tenseness / restlessness in last 2 weeks 1.2 1.9 2.6 1.6 -1.1
Hearing difficulty/problems with background noise 0.4 0.6 0.9 -0.6 -0.9
Hair/balding pattern: Pattern 2 1.4 1.8 2.1 -1.4 1.2
Had menopause 1.3 1.7 3.1 -0.6 1.8
Had other major operations 0.3 0.4 0.7 -0.8 -0.3
Forced vital capacity (FVC) 6.3 24.2 28.9 -4.4 -5.4
Heel bone mineral density (BMD) T-score, automated (right) 2.3 5.2 9.2 -1.1 3.0
Ever unenthusiastic/disinterested for a whole week 0.2 0.3 0.3 0.6 -0.5
Qualifications: None of the above 0.3 0.7 1.1 1.1 0.4
Financial difficulties in last 2 years 4.7 6.4 11.4 -1.2 -3.4
Mouth/teeth dental problems 0.3 0.5 1.0 -1.0 -0.1
Heart attack 1.0 1.2 2.3 1.5 0.4
Allergy 0.1 0.3 0.4 -0.4 -0.6
Pain all over the body in last month 0.4 0.4 0.7 0.8 0.2
Diabetes (self-reported) 2.2 3.3 4.5 1.5 2.1
Hayfever/allergic rhinitis (self-reported) 0.7 0.9 1.7 -0.0 1.3
Medication: Ramipril 2.2 2.9 4.5 1.1 2.1
Medication: Simvastatin 1.3 1.9 3.7 1.9 0.0
Fluid intelligence score 1.0 2.0 2.7 -1.1 -1.7
Illnesses of siblings 0.1 0.2 0.4 -0.6 -0.0
Neuroticism score 1.9 4.0 5.2 2.3 -1.6
Weight 4.1 20.1 24.6 -4.0 -5.0
Impedance of arm (right) 0.4 1.8 3.3 -1.8 0.5
Arm fat percentage (right) 0.4 1.5 2.4 -1.5 -0.8
Trunk fat-free mass 5.4 30.9 38.2 -4.9 -6.2
Hip circumference 5.4 23.4 37.5 -6.1 -3.1
Time employed in main current job 3.1 3.5 5.9 2.4 1.1
Alcohol intake versus 10 years previously 1.4 2.2 4.1 2.0 -0.4
Father’s age at death 0.0 0.0 0.1 -0.1 -0.2
Worrier / anxious feelings 1.2 2.2 3.1 1.8 -1.1
Frequency of tiredness / lethargy in last 2 weeks 0.9 1.4 2.2 0.8 -1.5
Falls in the last year 0.8 1.1 1.1 -1.1 1.0
Hair/balding pattern: Pattern 3 1.0 1.5 1.5 -1.2 -1.2
Number of live births 1.1 1.5 2.9 0.2 1.7
Forced expiratory volume in 1-second (FEV1) 5.7 19.2 27.4 -3.3 -5.2
Pulse rate 0.5 0.8 0.8 0.9 0.9
Happiness 1.4 1.7 2.1 1.2 -1.4
Noisy workplace 1.0 1.3 2.4 1.5 -0.4
Qualifications: A levels/AS levels or equivalent 1.1 2.5 4.6 -2.1 -0.7
Serious illness, injury or assault of a close relative in last 2 years 0.6 0.7 0.8 0.9 0.7
Mouth/teeth dental problems: Dentures 0.4 0.7 1.4 1.2 -0.3
Asthma 0.0 0.1 0.1 0.3 0.2
Medication: Ibuprofen (e.g. Nurofen) 0.5 0.6 1.0 1.0 0.5
Medication: Cholesterol lowering 1.9 2.9 5.3 2.3 0.7
Depression (self-reported) 1.3 1.5 2.5 -1.6 -0.8
Medication: Lansoprazole 0.1 0.2 0.2 0.4 -0.4
Prospective memory result 4.0 4.9 8.3 2.9 1.2
Lung cancer (father) 0.2 0.2 0.5 0.7 -0.1
Illnesses of mother 0.1 0.1 0.1 -0.3 -0.3
Forced expiratory volume in 1-second (FEV1), Best measure 3.4 10.8 14.4 -2.7 -3.8
Pulse wave Arterial Stiffness index 0.5 0.6 1.2 0.2 1.1
Impedance of arm (left) 0.4 1.8 3.5 -1.9 0.3
Arm fat mass (right) 1.4 5.7 5.8 -2.4 -2.4
Trunk predicted mass 5.3 30.3 37.8 -4.8 -6.2
Standing height 6.9 68.7 74.8 -7.9 -8.7
Length of working week for main job 0.2 0.3 0.5 -0.7 -0.0
Exposure to tobacco smoke at home 0.3 0.3 0.6 0.7 -0.2
Breastfed as a baby 1.2 1.5 1.7 -1.3 1.1
Tense / ‘highly strung’ 0.8 1.4 2.6 1.6 -0.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.3 0.6 0.8 0.1
Hair/balding pattern: Pattern 4 2.3 5.6 11.0 3.3 0.6
Birth weight of first child 0.9 1.7 3.3 -1.8 -0.1
Peak expiratory flow (PEF) 4.8 11.1 19.4 -1.7 -4.4
Pulse wave reflection index 0.4 0.5 0.5 -0.7 0.7
Ever highly irritable/argumentative for 2 days 0.2 0.2 0.4 -0.1 -0.6
Loud music exposure frequency 0.4 0.5 0.7 0.5 -0.9
Qualifications: O levels/GCSEs or equivalent 2.5 3.9 4.1 -1.9 -2.0
Mouth/teeth dental problems: Bleeding gums 0.2 0.3 0.5 -0.7 0.1
Blood clot in the leg (DVT) 0.3 0.4 0.7 0.8 0.2
Medication: Paracetamol 1.4 2.3 2.6 1.6 -1.5
Headache pain in last month 0.6 1.0 1.0 1.0 0.9
Medication for cholesterol, blood pressure or diabetes 2.1 3.4 5.2 -2.3 -1.3
Glaucoma (self-reported) 1.2 1.4 2.7 1.6 -0.1
Gout (self-reported) 0.6 0.8 1.3 0.6 1.1
Hypothyroidism/myxoedema (self-reported) 0.1 0.1 0.2 0.5 -0.1
Medication: Amlodipine 2.6 3.6 5.0 2.2 1.5
Medication: Ventolin 100micrograms inhaler 0.0 0.1 0.1 0.0 -0.3
Birth weight 1.4 3.0 4.7 -1.2 -2.2
Chronic bronchitis/emphysema (mother) 1.2 1.4 1.7 1.3 -1.1
High blood pressure (siblings) 0.6 0.8 1.6 1.3 0.1
Forced vital capacity (FVC), Best measure 3.7 13.7 14.7 -3.6 -3.8
Body fat percentage 0.4 1.7 2.7 -1.6 -0.8
Leg fat percentage (right) 0.2 0.9 1.1 -0.8 1.1
Arm fat-free mass (right) 4.4 22.4 29.3 -3.9 -5.4
Exposure to tobacco smoke outside home 1.8 2.4 4.6 2.2 0.3
Comparative body size at age 10 0.3 0.8 0.9 -0.9 -1.0
Number of full brothers 0.2 0.2 0.3 0.5 -0.5
Worry too long after embarrassment 1.8 3.0 5.6 0.7 -2.4
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.7 1.5 -0.1 -1.2
Wheeze or whistling in the chest in last year 0.0 0.0 0.0 -0.2 -0.1
Number of children fathered 0.4 0.4 0.8 -0.9 -0.2
Reason for reducing amount of alcohol drunk: Health precaution 2.2 2.5 4.1 -1.0 2.0
Age at first live birth 1.1 2.0 3.9 -2.0 0.1
Pulse wave peak to peak time 1.9 2.2 3.6 -0.9 -1.9
Health satisfaction 1.5 1.9 2.8 1.7 -1.1
Shortness of breath walking on level ground 0.6 0.7 1.1 0.5 1.1
Qualifications: College or University degree 1.5 4.7 6.8 -2.6 1.6
Eye problems/disorders: None of the above 0.7 0.8 1.6 -0.3 -1.3
Mouth/teeth dental problems: Loose teeth 1.2 1.4 1.8 1.0 1.4
Emphysema/chronic bronchitis 0.1 0.1 0.2 -0.5 -0.1
Medication for pain relief, constipation, heartburn 1.4 2.5 4.9 -2.2 -0.1
Neck or shoulder pain in last month 0.8 1.2 2.4 0.2 -1.5
Medication: Blood pressure 1.8 3.2 4.2 2.0 1.5
Angina (self-reported) 1.9 2.5 5.1 2.2 -0.0
Migraine (self-reported) 1.7 2.1 3.8 -0.7 1.9
Medication: Ibuprofen 0.6 0.7 1.3 1.1 0.3
Medication: Allopurinol 0.2 0.3 0.5 -0.2 0.7
Medication: Omeprazole 0.1 0.2 0.3 0.2 0.6
Medication: Seretide 50 evohaler 0.3 0.3 0.5 -0.4 -0.7
Mean time to correctly identify matches 0.0 0.0 0.0 -0.2 -0.1
Heart disease (mother) 0.2 0.2 0.4 0.7 0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.4 1.6 3.1 -1.8 -0.4
Whole body fat mass 1.5 6.5 6.9 -2.5 -2.6
Leg fat mass (right) 0.9 3.4 4.0 -2.0 -1.7
Arm predicted mass (right) 4.0 20.3 26.5 -3.8 -5.2
Pulse rate, automated reading 0.8 2.7 3.5 1.4 1.9
Alcohol intake frequency. 2.2 5.1 7.5 2.7 1.6
Comparative height size at age 10 5.9 32.4 35.2 -5.5 -5.9
Number of full sisters 2.4 2.9 5.1 2.3 0.8
Suffer from ‘nerves’ 0.8 1.2 2.5 1.6 0.1
Overall health rating 2.7 5.8 11.6 3.4 -0.1
Chest pain or discomfort 0.1 0.2 0.2 0.5 0.4
Had major operations 1.0 1.2 1.5 0.9 -1.2
Age at last live birth 0.0 0.0 0.0 0.2 -0.1
Family relationship satisfaction 1.5 1.8 2.3 1.1 -1.5
Leg pain on walking 0.2 0.3 0.6 0.0 -0.8
Qualifications: NVQ or HND or HNC or equivalent 0.7 0.9 1.6 -0.3 -1.3
Commuting to job workplace: Car/motor vehicle 0.3 0.4 0.7 -0.9 -0.1
Illness, injury, bereavement, stress in last 2 years 0.5 0.7 0.7 -0.8 0.8
Medication: Aspirin 2.2 2.8 5.6 2.4 0.3
Supplements: Vitamin C 1.1 1.3 2.6 -1.6 0.3
Knee pain experienced in last month 0.0 0.0 0.0 -0.1 0.2
Hypertension (Self-reported) 1.2 3.4 3.5 1.9 1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.0 1.1 2.0 -0.5 -1.4
Illnesses of father: Heart disease 0.9 1.3 1.9 1.4 0.8
Illnesses of siblings: Diabetes 1.5 1.8 2.8 1.7 0.9
Smoking status: Previous 1.8 2.7 5.3 0.1 -2.3
Forced expiratory volume in 1-second (FEV1), predicted 4.4 9.2 14.7 -1.9 -3.8
Whole body fat-free mass 5.3 30.5 40.4 -4.5 -6.4
Leg fat-free mass (right) 5.7 30.5 45.9 -3.9 -6.8
Arm fat percentage (left) 0.4 1.5 1.9 -1.4 -1.1
Average weekly red wine intake 3.6 5.3 8.4 -2.9 -1.5
Handedness (chirality/laterality): Left-handed 0.2 0.2 0.3 -0.5 -0.3
Mood swings 0.8 1.4 2.8 1.7 -0.3
Loneliness, isolation 0.2 0.3 0.4 0.5 -0.7
Long-standing illness, disability or infirmity 0.8 1.2 2.1 1.4 -0.6
Ever had bowel cancer screening 3.1 3.6 3.8 -2.0 1.9
Diabetes diagnosed by doctor 2.4 4.0 5.3 1.6 2.3
Ever had stillbirth, spontaneous miscarriage or termination 0.1 0.1 0.2 -0.5 0.1
Friendships satisfaction 0.5 0.6 1.1 -0.2 -1.0
Qualifications: nursing, teaching 3.0 4.6 8.8 -3.0 -0.7
Commuting to job workplace: Walk 1.6 1.7 1.9 1.4 -1.3
Eye problems/disorders: Cataract 1.5 1.8 2.9 -0.8 1.7
Mouth/teeth dental problems: Mouth ulcers 1.4 2.2 4.2 -0.3 -2.1
Medication for cholesterol 0.2 0.3 0.5 -0.1 -0.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.3 1.5 2.4 1.6 -0.8
Back pain experienced in last month 0.2 0.3 0.4 -0.4 -0.6
Mineral and other dietary supplements 0.9 1.2 1.5 1.2 1.0
Breast cancer (self-reported) 0.7 0.8 1.6 -1.3 0.3
Asthma (self-reported) 0.2 0.4 0.4 0.6 0.6
Osteoporosis (self-reported) 0.1 0.1 0.2 -0.3 -0.5
Osteoarthritis (self-reported) 0.0 0.1 0.1 -0.3 0.0
Medication: Aspirin 1.9 2.5 4.9 2.2 0.3
Medication: Gliclazide 0.2 0.3 0.5 0.7 -0.0
Illnesses of father: None of the above (group 1) 2.1 2.6 4.0 -2.0 -1.1
Smoking status: Current 0.8 1.2 2.3 1.5 0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.0 1.1 -1.1 -0.9
Whole body water mass 5.3 30.0 40.6 -4.4 -6.4
Leg predicted mass (right) 5.6 30.1 45.2 -3.9 -6.7
Arm fat mass (left) 1.4 5.7 7.1 -2.1 -2.7
Number of self-reported non-cancer illnesses 0.2 0.4 0.6 0.8 0.3
Average weekly champagne plus white wine intake 1.1 1.6 2.3 -1.5 0.9
Miserableness 1.2 2.1 3.6 0.8 -1.9
Guilty feelings 0.4 0.6 1.1 -0.2 -1.0
Wears glasses or contact lenses 0.4 0.4 0.9 0.0 0.9
Ever taken oral contraceptive pill 0.3 0.3 0.5 -0.7 0.4
Hearing aid user 2.2 2.4 4.8 -2.2 -0.3
Mother’s age at death 0.7 0.9 1.6 -1.3 0.5
Financial situation satisfaction 0.9 1.1 1.5 -0.9 -1.2
Tinnitus: Yes, now most or all of the time 1.4 1.7 2.6 -0.8 -1.6
Commuting to job workplace: Public transport 0.9 1.0 2.0 0.2 1.4
Eye problems/disorders: Glaucoma 1.3 1.6 3.0 1.7 -0.4
Medication: Blood pressure 0.8 1.4 2.8 0.3 1.7
Pain type(s) experienced in last month: Hip pain 0.0 0.0 0.0 0.2 -0.1
Supplements: Fish oil (including cod liver oil) 0.7 0.9 1.0 -1.0 -1.0
High cholesterol (Self-reported) 1.5 2.6 5.2 2.3 -0.3
Medication: Bendroflumethiazide 0.9 1.3 2.2 1.5 0.6
Medication: Paracetamol 2.3 3.5 5.0 2.2 -1.4
Medication: Lisinopril 0.6 0.8 1.2 1.1 0.6
Medication: Atorvastatin 1.8 2.2 3.2 1.8 1.1
Illnesses of father: High blood pressure 1.2 1.5 2.9 1.7 0.4
Alcohol drinker status: Never 0.9 1.1 1.9 1.4 0.6
Ever smoked 3.3 5.8 10.9 0.8 -3.3
Basal metabolic rate 5.3 29.4 38.8 -4.5 -6.2
Leg fat percentage (left) 0.1 0.5 0.7 -0.5 0.8
Arm fat-free mass (left) 3.8 19.4 25.0 -3.7 -5.0
Number of operations (self-reported) 0.4 0.6 1.0 0.5 -1.0
Average weekly beer plus cider intake 0.2 0.3 0.5 0.1 -0.7
Irritability 1.8 3.0 3.6 1.9 -1.5
Risk taking 0.4 0.6 1.1 -0.3 1.0
Ever had prostate specific antigen (PSA) test 2.3 2.6 3.0 -1.7 1.5
Fractured/broken bones in last 5 years 1.0 1.3 2.2 0.7 -1.5
Age started oral contraceptive pill 0.8 1.0 2.0 -0.1 1.4
Diastolic blood pressure, automated reading 0.4 1.2 2.3 -1.5 -0.1
Ever depressed for a whole week 0.2 0.2 0.3 -0.2 -0.6
Unable to work because of sickness or disability 1.5 1.9 3.5 1.9 -0.6
Commuting to job workplace: Cycle 0.0 0.0 0.1 0.0 -0.3
Myopia 0.6 0.9 1.8 -0.3 -1.3
Vascular/heart problems diagnosed by doctor 1.6 4.4 5.4 -2.3 -1.8
Cholesterol lowering medication 0.5 0.7 1.1 1.1 0.5
Medication: Omeprazole (e.g. Zanprol) 0.0 0.0 0.0 0.1 0.0
Pain experienced in last month 0.1 0.1 0.1 0.3 0.3
Supplements: Calcium 1.3 1.4 2.6 -1.6 0.5
Basal cell carcinoma (self-reported) 0.5 0.6 0.9 -0.5 1.0
Heart attack/myocardial infarction (self-reported) 1.0 1.3 2.2 1.5 0.7
Deep venous thrombosis (DVT) (self-reported) 0.4 0.6 1.1 1.0 0.2
Heart disease (siblings) 0.1 0.1 0.1 -0.4 0.1
Alcohol drinker status: Previous 2.6 2.9 4.1 2.0 -1.3
Pack years of smoking 2.2 3.3 3.6 1.9 1.7
Impedance of whole body 0.3 1.5 2.5 -0.7 1.6
Leg fat mass (left) 0.8 3.2 3.5 -1.7 -1.9
Arm predicted mass (left) 3.9 19.9 26.0 -3.7 -5.1