TWAS hub - COPG1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cortex	0.2440	0.0900	0.00360	0.001	NA	0.029	NA	0.028	0.30000	NA	0.05300	NA	0.05700
2	METSIM	Adipose	0.0414	0.0184	0.00015	0.018	0.032	0.022	0.033	0.021	0.00079	1.1e-05	0.00026	7.6e-06	0.00032

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Waist Hip Ratio (WHR)	10.3	46.3	91.6	9.6	-1.0
Height	6.9	132.7	148.8	-12.2	-10.8
Standing height	6.9	68.7	74.8	-7.9	-8.7
Forced vital capacity (FVC)	6.3	24.2	28.9	-4.4	-5.4
Comparative height size at age 10	5.9	32.4	35.2	-5.5	-5.9
Forced expiratory volume in 1-second (FEV1)	5.7	19.2	27.4	-3.3	-5.2
Leg fat-free mass (right)	5.7	30.5	45.9	-3.9	-6.8
Leg predicted mass (right)	5.6	30.1	45.2	-3.9	-6.7
Sitting height	5.5	39.0	41.3	-6.4	-6.1
Leg fat-free mass (left)	5.4	28.5	41.2	-4.0	-6.4
Trunk fat-free mass	5.4	30.9	38.2	-4.9	-6.2
Hip circumference	5.4	23.4	37.5	-6.1	-3.1
Leg predicted mass (left)	5.3	28.1	40.4	-4.0	-6.4
Trunk predicted mass	5.3	30.3	37.8	-4.8	-6.2
Whole body fat-free mass	5.3	30.5	40.4	-4.5	-6.4
Whole body water mass	5.3	30.0	40.6	-4.4	-6.4
Basal metabolic rate	5.3	29.4	38.8	-4.5	-6.2
Peak expiratory flow (PEF)	4.8	11.1	19.4	-1.7	-4.4
Financial difficulties in last 2 years	4.7	6.4	11.4	-1.2	-3.4
Arm fat-free mass (right)	4.4	22.4	29.3	-3.9	-5.4
Forced expiratory volume in 1-second (FEV1), predicted	4.4	9.2	14.7	-1.9	-3.8
Coronary Artery Disease (CAD)	4.2	5.0	10.0	3.2	-0.0
Weight	4.1	20.1	24.6	-4.0	-5.0
Prospective memory result	4.0	4.9	8.3	2.9	1.2
Arm predicted mass (right)	4.0	20.3	26.5	-3.8	-5.2
Arm predicted mass (left)	3.9	19.9	26.0	-3.7	-5.1
Arm fat-free mass (left)	3.8	19.4	25.0	-3.7	-5.0
Forced vital capacity (FVC), Best measure	3.7	13.7	14.7	-3.6	-3.8
Bipolar Disorder (2011)	3.6	3.5	6.8	-0.4	2.6
Average weekly red wine intake	3.6	5.3	8.4	-2.9	-1.5
Hand grip strength (left)	3.5	9.3	13.1	-2.3	-3.6
Medication: Metformin	3.5	4.9	7.7	1.4	2.8
Diabetes (mother)	3.5	4.5	8.8	3.0	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	3.4	10.8	14.4	-2.7	-3.8
Ever smoked	3.3	5.8	10.9	0.8	-3.3
Pack years adult smoking proportion	3.1	4.8	6.4	2.5	1.8
Time employed in main current job	3.1	3.5	5.9	2.4	1.1
Ever had bowel cancer screening	3.1	3.6	3.8	-2.0	1.9
Schizophrenia (2014)	3.0	6.6	13.0	0.3	3.6
Diabetes (father)	3.0	3.7	4.2	2.0	1.8
Qualifications: nursing, teaching	3.0	4.6	8.8	-3.0	-0.7
Past tobacco smoking	2.9	5.4	10.6	-0.4	3.3
Alcohol usually taken with meals	2.8	4.5	9.0	-3.0	-0.1
Overall health rating	2.7	5.8	11.6	3.4	-0.1
Bipolar Disorder (2018)	2.6	4.2	7.5	-0.9	2.7
Cardiovascular Disease	2.6	8.5	16.2	4.0	0.9
Hand grip strength (right)	2.6	7.0	11.5	-1.6	-3.4
Medication: Amlodipine	2.6	3.6	5.0	2.2	1.5
Alcohol drinker status: Previous	2.6	2.9	4.1	2.0	-1.3
Bipolar Disorder or Schizophrenia	2.5	6.0	12.0	-0.3	3.5
Severe depression (siblings)	2.5	2.7	5.0	2.2	-0.7
Qualifications: O levels/GCSEs or equivalent	2.5	3.9	4.1	-1.9	-2.0
Angina	2.4	3.1	6.1	2.5	-0.3
Number of full sisters	2.4	2.9	5.1	2.3	0.8
Diabetes diagnosed by doctor	2.4	4.0	5.3	1.6	2.3
Heel bone mineral density (BMD) T-score, automated (right)	2.3	5.2	9.2	-1.1	3.0
Hair/balding pattern: Pattern 4	2.3	5.6	11.0	3.3	0.6
Medication: Paracetamol	2.3	3.5	5.0	2.2	-1.4
Ever had prostate specific antigen (PSA) test	2.3	2.6	3.0	-1.7	1.5
Type 2 Diabetes (T2D) (2012)	2.2	2.6	4.3	2.1	0.9
Hearing difficulty/problems: Yes	2.2	3.4	3.7	-1.9	-1.7
Other serious medical condition/disability diagnosed by doctor	2.2	2.9	3.2	-1.8	-1.6
Diverticular disease/diverticulitis (self-reported)	2.2	2.6	3.0	-1.4	1.7
Diabetes (self-reported)	2.2	3.3	4.5	1.5	2.1
Medication: Ramipril	2.2	2.9	4.5	1.1	2.1
Reason for reducing amount of alcohol drunk: Health precaution	2.2	2.5	4.1	-1.0	2.0
Alcohol intake frequency.	2.2	5.1	7.5	2.7	1.6
Medication: Aspirin	2.2	2.8	5.6	2.4	0.3
Hearing aid user	2.2	2.4	4.8	-2.2	-0.3
Pack years of smoking	2.2	3.3	3.6	1.9	1.7
Neuroticism	2.1	5.1	6.9	2.6	-1.8
Medication for cholesterol, blood pressure or diabetes	2.1	3.4	5.2	-2.3	-1.3
Illnesses of father: None of the above (group 1)	2.1	2.6	4.0	-2.0	-1.1
Trunk fat mass	2.0	8.7	9.4	-2.8	-3.1
HbA1C	1.9	2.1	4.1	-0.3	2.0
Heel T-Score	1.9	15.2	23.8	-2.5	4.9
Smoking Status	1.9	4.5	6.0	1.8	-2.5
Neuroticism score	1.9	4.0	5.2	2.3	-1.6
Medication: Cholesterol lowering	1.9	2.9	5.3	2.3	0.7
Pulse wave peak to peak time	1.9	2.2	3.6	-0.9	-1.9
Angina (self-reported)	1.9	2.5	5.1	2.2	-0.0
Medication: Aspirin	1.9	2.5	4.9	2.2	0.3
Alzheimer’s Disease (in father)	1.8	1.9	3.8	1.9	0.1
Supplements: Zinc	1.8	2.0	3.8	-0.5	1.9
Heel bone mineral density (BMD) T-score, automated (left)	1.8	4.1	8.1	0.2	2.9
Exposure to tobacco smoke outside home	1.8	2.4	4.6	2.2	0.3
Worry too long after embarrassment	1.8	3.0	5.6	0.7	-2.4
Medication: Blood pressure	1.8	3.2	4.2	2.0	1.5
Smoking status: Previous	1.8	2.7	5.3	0.1	-2.3
Medication: Atorvastatin	1.8	2.2	3.2	1.8	1.1
Irritability	1.8	3.0	3.6	1.9	-1.5
Rheumatoid Arthritis	1.7	2.3	2.4	1.5	1.5
Frequency of depressed mood in last 2 weeks	1.7	2.4	3.7	1.1	-1.9
Stomach or abdominal pain in last month	1.7	2.1	4.0	2.0	-0.5
Migraine (self-reported)	1.7	2.1	3.8	-0.7	1.9
Blood Eosinophil Count	1.6	12.5	13.8	-3.7	3.4
Average weekly fortified wine intake	1.6	1.8	3.0	-1.7	-0.8
Commuting to job workplace: Walk	1.6	1.7	1.9	1.4	-1.3
Vascular/heart problems diagnosed by doctor	1.6	4.4	5.4	-2.3	-1.8
Breast Cancer	1.5	3.7	6.6	0.9	2.6
Fed-up feelings	1.5	2.6	3.4	1.4	-1.8
Health satisfaction	1.5	1.9	2.8	1.7	-1.1
Qualifications: College or University degree	1.5	4.7	6.8	-2.6	1.6
Whole body fat mass	1.5	6.5	6.9	-2.5	-2.6
Family relationship satisfaction	1.5	1.8	2.3	1.1	-1.5
Illnesses of siblings: Diabetes	1.5	1.8	2.8	1.7	0.9
Eye problems/disorders: Cataract	1.5	1.8	2.9	-0.8	1.7
High cholesterol (Self-reported)	1.5	2.6	5.2	2.3	-0.3
Unable to work because of sickness or disability	1.5	1.9	3.5	1.9	-0.6
Maternal smoking around birth	1.4	2.0	2.1	1.4	-1.4
Supplements: Glucosamine	1.4	1.9	2.9	-1.7	-0.9
Medication: Atenolol	1.4	1.7	3.1	1.8	0.5
Number of incorrect matches in round	1.4	2.3	2.3	-1.5	1.5
Hair/balding pattern: Pattern 2	1.4	1.8	2.1	-1.4	1.2
Alcohol intake versus 10 years previously	1.4	2.2	4.1	2.0	-0.4
Happiness	1.4	1.7	2.1	1.2	-1.4
Arm fat mass (right)	1.4	5.7	5.8	-2.4	-2.4
Medication: Paracetamol	1.4	2.3	2.6	1.6	-1.5
Birth weight	1.4	3.0	4.7	-1.2	-2.2
Medication for pain relief, constipation, heartburn	1.4	2.5	4.9	-2.2	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.4	1.6	3.1	-1.8	-0.4
Mouth/teeth dental problems: Mouth ulcers	1.4	2.2	4.2	-0.3	-2.1
Arm fat mass (left)	1.4	5.7	7.1	-2.1	-2.7
Tinnitus: Yes, now most or all of the time	1.4	1.7	2.6	-0.8	-1.6
Intelligence (Savage-Jansen 2018)	1.3	4.1	5.2	-1.7	-2.3
Neuroticism (Nagel 2018)	1.3	3.1	3.3	1.7	-1.8
Impedance of leg (right)	1.3	6.2	12.3	0.1	3.5
Had menopause	1.3	1.7	3.1	-0.6	1.8
Medication: Simvastatin	1.3	1.9	3.7	1.9	0.0
Depression (self-reported)	1.3	1.5	2.5	-1.6	-0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.3	1.5	2.4	1.6	-0.8
Eye problems/disorders: Glaucoma	1.3	1.6	3.0	1.7	-0.4
Supplements: Calcium	1.3	1.4	2.6	-1.6	0.5
Depressed Affect (Nagel 2018)	1.2	2.4	2.5	1.5	-1.6
Schizophrenia (2018)	1.2	2.6	5.0	0.3	2.2
Worry (Nagel 2018)	1.2	2.5	5.0	2.2	-0.3
Age at First Birth	1.2	1.7	3.1	-1.8	-0.5
Fasting Glucose	1.2	1.4	1.6	1.3	1.1
High blood pressure	1.2	3.4	4.0	2.0	1.7
Frequency of tenseness / restlessness in last 2 weeks	1.2	1.9	2.6	1.6	-1.1
Worrier / anxious feelings	1.2	2.2	3.1	1.8	-1.1
Breastfed as a baby	1.2	1.5	1.7	-1.3	1.1
Glaucoma (self-reported)	1.2	1.4	2.7	1.6	-0.1
Chronic bronchitis/emphysema (mother)	1.2	1.4	1.7	1.3	-1.1
Mouth/teeth dental problems: Loose teeth	1.2	1.4	1.8	1.0	1.4
Hypertension (Self-reported)	1.2	3.4	3.5	1.9	1.8
Miserableness	1.2	2.1	3.6	0.8	-1.9
Illnesses of father: High blood pressure	1.2	1.5	2.9	1.7	0.4
Alzheimer’s Disease (including proxy)	1.1	1.6	2.9	1.7	0.6
Reaction Time	1.1	2.0	2.6	1.6	-1.2
Neuroticism (2016)	1.1	1.5	1.8	1.3	-1.1
Number of treatments/medications taken	1.1	1.9	3.2	1.8	0.8
Medication for hormone replacement therapy	1.1	1.3	1.7	-0.9	-1.3
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.4	1.6	1.1	-1.3
Impedance of leg (left)	1.1	5.4	10.8	0.2	3.3
Number of live births	1.1	1.5	2.9	0.2	1.7
Qualifications: A levels/AS levels or equivalent	1.1	2.5	4.6	-2.1	-0.7
Age at first live birth	1.1	2.0	3.9	-2.0	0.1
Supplements: Vitamin C	1.1	1.3	2.6	-1.6	0.3
Average weekly champagne plus white wine intake	1.1	1.6	2.3	-1.5	0.9
Prostate Cancer	1.0	1.4	1.6	-1.3	-1.1
Mean Putamen Volume	1.0	1.1	1.5	0.9	-1.2
Primary Biliary Cirrhosis	1.0	1.4	2.6	-0.4	1.6
Lung FVC	1.0	4.9	9.7	-3.1	-0.1
Townsend deprivation index at recruitment	1.0	1.5	2.4	0.7	-1.6
Chronic bronchitis/emphysema (father)	1.0	1.1	1.3	-1.0	-1.1
Nervous feelings	1.0	1.8	3.3	1.8	-0.6
Heart attack	1.0	1.2	2.3	1.5	0.4
Fluid intelligence score	1.0	2.0	2.7	-1.1	-1.7
Hair/balding pattern: Pattern 3	1.0	1.5	1.5	-1.2	-1.2
Noisy workplace	1.0	1.3	2.4	1.5	-0.4
Had major operations	1.0	1.2	1.5	0.9	-1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.1	2.0	-0.5	-1.4
Fractured/broken bones in last 5 years	1.0	1.3	2.2	0.7	-1.5
Heart attack/myocardial infarction (self-reported)	1.0	1.3	2.2	1.5	0.7
Current tobacco smoking	0.9	1.5	2.8	1.7	0.4
Qualifications: CSEs or equivalent	0.9	1.2	2.1	0.5	-1.5
Waist circumference	0.9	3.3	6.4	0.3	-2.5
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.4	2.2	0.8	-1.5
Birth weight of first child	0.9	1.7	3.3	-1.8	-0.1
Leg fat mass (right)	0.9	3.4	4.0	-2.0	-1.7
Illnesses of father: Heart disease	0.9	1.3	1.9	1.4	0.8
Mineral and other dietary supplements	0.9	1.2	1.5	1.2	1.0
Financial situation satisfaction	0.9	1.1	1.5	-0.9	-1.2
Commuting to job workplace: Public transport	0.9	1.0	2.0	0.2	1.4
Medication: Bendroflumethiazide	0.9	1.3	2.2	1.5	0.6
Alcohol drinker status: Never	0.9	1.1	1.9	1.4	0.6
LDL Cholesterol	0.8	1.3	2.3	1.5	-0.5
Type 2 Diabetes (T2D) (2018)	0.8	1.5	2.1	1.5	1.0
Trunk fat percentage	0.8	3.1	4.0	-2.0	-1.4
Falls in the last year	0.8	1.1	1.1	-1.1	1.0
Tense / ‘highly strung’	0.8	1.4	2.6	1.6	-0.4
Neck or shoulder pain in last month	0.8	1.2	2.4	0.2	-1.5
Pulse rate, automated reading	0.8	2.7	3.5	1.4	1.9
Suffer from ‘nerves’	0.8	1.2	2.5	1.6	0.1
Mood swings	0.8	1.4	2.8	1.7	-0.3
Long-standing illness, disability or infirmity	0.8	1.2	2.1	1.4	-0.6
Smoking status: Current	0.8	1.2	2.3	1.5	0.3
Medication: Blood pressure	0.8	1.4	2.8	0.3	1.7
Age started oral contraceptive pill	0.8	1.0	2.0	-0.1	1.4
Leg fat mass (left)	0.8	3.2	3.5	-1.7	-1.9
Relative age of first facial hair	0.7	1.5	2.3	1.5	0.8
Eye problems/disorders: Diabetes related eye disease	0.7	0.7	1.1	-0.6	1.0
Taking other prescription medications	0.7	1.1	1.9	1.4	0.5
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	1.7	-0.0	1.3
Eye problems/disorders: None of the above	0.7	0.8	1.6	-0.3	-1.3
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	1.6	-0.3	-1.3
Breast cancer (self-reported)	0.7	0.8	1.6	-1.3	0.3
Mother’s age at death	0.7	0.9	1.6	-1.3	0.5
Supplements: Fish oil (including cod liver oil)	0.7	0.9	1.0	-1.0	-1.0
Alzheimer’s Disease (in mother)	0.6	0.7	1.2	-1.1	0.4
Triglycerides	0.6	0.9	1.1	0.9	1.0
Systolic Blood Pressure	0.6	2.9	4.2	2.1	1.2
Sensitivity / hurt feelings	0.6	1.0	2.0	-0.1	-1.4
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	0.8	0.9	0.7
Headache pain in last month	0.6	1.0	1.0	1.0	0.9
Gout (self-reported)	0.6	0.8	1.3	0.6	1.1
High blood pressure (siblings)	0.6	0.8	1.6	1.3	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.7	1.5	-0.1	-1.2
Shortness of breath walking on level ground	0.6	0.7	1.1	0.5	1.1
Medication: Ibuprofen	0.6	0.7	1.3	1.1	0.3
Medication: Lisinopril	0.6	0.8	1.2	1.1	0.6
Myopia	0.6	0.9	1.8	-0.3	-1.3
Ulcerative Colitis (UC)	0.5	0.8	1.6	1.3	0.3
BMI	0.5	2.6	5.2	-0.2	-2.3
Multivitamins +/- minerals	0.5	0.6	1.1	-1.1	-0.2
Pulse rate	0.5	0.8	0.8	0.9	0.9
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	1.0	1.0	0.5
Pulse wave Arterial Stiffness index	0.5	0.6	1.2	0.2	1.1
Illness, injury, bereavement, stress in last 2 years	0.5	0.7	0.7	-0.8	0.8
Friendships satisfaction	0.5	0.6	1.1	-0.2	-1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	1.1	-1.1	-0.9
Cholesterol lowering medication	0.5	0.7	1.1	1.1	0.5
Basal cell carcinoma (self-reported)	0.5	0.6	0.9	-0.5	1.0
Body Mass Index (BMI) (2010)	0.4	0.6	0.9	-0.5	0.9
Crohns Disease (2012)	0.4	0.6	1.1	-0.3	1.0
Ulcerative Colitis	0.4	0.6	0.9	1.0	0.4
Blood Red Count	0.4	4.1	5.2	-2.3	1.7
Blood White Count	0.4	2.9	3.6	1.5	-1.9
Chronotype (morning person)	0.4	0.9	1.7	-0.1	-1.3
Ever had hysterectomy (womb removed)	0.4	0.4	0.7	-0.3	0.9
Age when periods started (menarche)	0.4	1.0	1.7	-1.3	0.5
Medication: Levothyroxine sodium	0.4	0.7	0.9	0.9	-0.7
Hearing difficulty/problems with background noise	0.4	0.6	0.9	-0.6	-0.9
Pain all over the body in last month	0.4	0.4	0.7	0.8	0.2
Impedance of arm (right)	0.4	1.8	3.3	-1.8	0.5
Arm fat percentage (right)	0.4	1.5	2.4	-1.5	-0.8
Mouth/teeth dental problems: Dentures	0.4	0.7	1.4	1.2	-0.3
Impedance of arm (left)	0.4	1.8	3.5	-1.9	0.3
Pulse wave reflection index	0.4	0.5	0.5	-0.7	0.7
Loud music exposure frequency	0.4	0.5	0.7	0.5	-0.9
Body fat percentage	0.4	1.7	2.7	-1.6	-0.8
Number of children fathered	0.4	0.4	0.8	-0.9	-0.2
Arm fat percentage (left)	0.4	1.5	1.9	-1.4	-1.1
Guilty feelings	0.4	0.6	1.1	-0.2	-1.0
Wears glasses or contact lenses	0.4	0.4	0.9	0.0	0.9
Number of operations (self-reported)	0.4	0.6	1.0	0.5	-1.0
Risk taking	0.4	0.6	1.1	-0.3	1.0
Diastolic blood pressure, automated reading	0.4	1.2	2.3	-1.5	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.4	0.6	1.1	1.0	0.2
Ovarian Cancer	0.3	0.4	0.6	-0.4	0.8
Lupus	0.3	0.4	0.5	-0.7	0.6
Lung FEV1/FVC ratio	0.3	1.7	2.0	1.4	-1.1
Ever used hormone-replacement therapy (HRT)	0.3	0.4	0.5	-0.6	0.7
Medication: Co-codamol	0.3	0.3	0.7	0.2	-0.8
High blood pressure (mother)	0.3	0.5	0.7	0.5	-0.8
Had other major operations	0.3	0.4	0.7	-0.8	-0.3
Qualifications: None of the above	0.3	0.7	1.1	1.1	0.4
Mouth/teeth dental problems	0.3	0.5	1.0	-1.0	-0.1
Exposure to tobacco smoke at home	0.3	0.3	0.6	0.7	-0.2
Blood clot in the leg (DVT)	0.3	0.4	0.7	0.8	0.2
Comparative body size at age 10	0.3	0.8	0.9	-0.9	-1.0
Medication: Seretide 50 evohaler	0.3	0.3	0.5	-0.4	-0.7
Commuting to job workplace: Car/motor vehicle	0.3	0.4	0.7	-0.9	-0.1
Ever taken oral contraceptive pill	0.3	0.3	0.5	-0.7	0.4
Impedance of whole body	0.3	1.5	2.5	-0.7	1.6
Depression (Nagel 2018)	0.2	0.3	0.3	0.6	-0.6
Schizophrenia vs Biploar Disorder	0.2	0.2	0.5	0.7	0.1
Crohns Disease (2017)	0.2	0.4	0.7	-0.8	-0.4
Verbal and Numeric Reasoning (VNR)	0.2	0.5	0.8	-0.5	-0.9
Blood Platelet Count	0.2	1.9	3.3	1.8	0.7
Hypothyroidism (self reported)	0.2	0.4	0.5	-0.7	-0.6
Average weekly spirits intake	0.2	0.2	0.4	-0.6	-0.1
Systolic blood pressure, automated reading	0.2	0.6	1.2	0.0	1.1
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.4	-0.1	-0.6
Hayfever, allergic rhinitis or eczema	0.2	0.5	0.5	-0.7	0.7
Body mass index (BMI)	0.2	1.0	1.8	-0.4	-1.4
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.3	0.6	-0.5
Lung cancer (father)	0.2	0.2	0.5	0.7	-0.1
Length of working week for main job	0.2	0.3	0.5	-0.7	-0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.6	0.8	0.1
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.4	-0.1	-0.6
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.5	-0.7	0.1
Leg fat percentage (right)	0.2	0.9	1.1	-0.8	1.1
Number of full brothers	0.2	0.2	0.3	0.5	-0.5
Medication: Allopurinol	0.2	0.3	0.5	-0.2	0.7
Heart disease (mother)	0.2	0.2	0.4	0.7	0.0
Leg pain on walking	0.2	0.3	0.6	0.0	-0.8
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.3	-0.5	-0.3
Loneliness, isolation	0.2	0.3	0.4	0.5	-0.7
Medication for cholesterol	0.2	0.3	0.5	-0.1	-0.7
Back pain experienced in last month	0.2	0.3	0.4	-0.4	-0.6
Asthma (self-reported)	0.2	0.4	0.4	0.6	0.6
Medication: Gliclazide	0.2	0.3	0.5	0.7	-0.0
Number of self-reported non-cancer illnesses	0.2	0.4	0.6	0.8	0.3
Average weekly beer plus cider intake	0.2	0.3	0.5	0.1	-0.7
Ever depressed for a whole week	0.2	0.2	0.3	-0.2	-0.6
HDL Cholesterol	0.1	0.1	0.2	0.4	-0.3
Allergy or Eczema	0.1	0.2	0.4	0.1	0.7
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.2	0.5	0.2
Serious illness, injury or assault to yourself	0.1	0.2	0.3	-0.5	0.3
Allergy	0.1	0.3	0.4	-0.4	-0.6
Illnesses of siblings	0.1	0.2	0.4	-0.6	-0.0
Medication: Lansoprazole	0.1	0.2	0.2	0.4	-0.4
Illnesses of mother	0.1	0.1	0.1	-0.3	-0.3
Hypothyroidism/myxoedema (self-reported)	0.1	0.1	0.2	0.5	-0.1
Emphysema/chronic bronchitis	0.1	0.1	0.2	-0.5	-0.1
Medication: Omeprazole	0.1	0.2	0.3	0.2	0.6
Chest pain or discomfort	0.1	0.2	0.2	0.5	0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.2	-0.5	0.1
Osteoporosis (self-reported)	0.1	0.1	0.2	-0.3	-0.5
Leg fat percentage (left)	0.1	0.5	0.7	-0.5	0.8
Pain experienced in last month	0.1	0.1	0.1	0.3	0.3
Heart disease (siblings)	0.1	0.1	0.1	-0.4	0.1
Irritable Bowel Disease (IBD)	0.0	0.0	0.1	0.3	0.0
Major Depression (MDD)	0.0	0.0	0.1	0.1	-0.2
Respiratory disease	0.0	0.1	0.1	0.4	0.1
Hair Pigment	0.0	1.1	1.9	-1.4	0.6
Tanning	0.0	0.3	0.6	-0.1	-0.8
Vitamin and mineral supplements	0.0	0.0	0.0	0.1	-0.2
Relative age voice broke	0.0	0.0	0.1	0.1	0.3
Father’s age at death	0.0	0.0	0.1	-0.1	-0.2
Asthma	0.0	0.1	0.1	0.3	0.2
Medication: Ventolin 100micrograms inhaler	0.0	0.1	0.1	0.0	-0.3
Wheeze or whistling in the chest in last year	0.0	0.0	0.0	-0.2	-0.1
Mean time to correctly identify matches	0.0	0.0	0.0	-0.2	-0.1
Age at last live birth	0.0	0.0	0.0	0.2	-0.1
Knee pain experienced in last month	0.0	0.0	0.0	-0.1	0.2
Osteoarthritis (self-reported)	0.0	0.1	0.1	-0.3	0.0
Pain type(s) experienced in last month: Hip pain	0.0	0.0	0.0	0.2	-0.1
Commuting to job workplace: Cycle	0.0	0.0	0.1	0.0	-0.3
Medication: Omeprazole (e.g. Zanprol)	0.0	0.0	0.0	0.1	0.0

Hub : Genes

COPG1

Models

Trait associations