Best TWAS P=2.19e-14 · Best GWAS P=1.48e-12 conditioned to 0.00477
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Cerebellum | RP11-385F7.1 | 0.35 | 0.32 | lasso | 4 | 0.30 | 1.5e-09 | 6.0 | -6.0 | 1.8e-09 | 0.37 | 0.90 | 0.09 | FALSE |
| 2 | GTEx | Colon Transverse | RP11-385F7.1 | 0.15 | 0.03 | enet | 7 | 0.05 | 2.1e-03 | 6.1 | -5.8 | 6.3e-09 | 0.29 | 0.23 | 0.54 | FALSE |
| 3 | GTEx | Esophagus Mucosa | RP11-385F7.1 | 0.20 | 0.10 | lasso | 20 | 0.07 | 1.6e-05 | 6.0 | -6.9 | 5.9e-12 | 0.56 | 0.33 | 0.66 | FALSE |
| 4 | GTEx | Esophagus Muscularis | RP11-385F7.1 | 0.13 | 0.06 | lasso | 4 | 0.06 | 2.1e-04 | 6.1 | -6.6 | 4.3e-11 | 0.33 | 0.62 | 0.15 | FALSE |
| 5 | GTEx | Pituitary | RP11-385F7.1 | 0.26 | 0.21 | lasso | 5 | 0.16 | 7.7e-05 | 6.0 | -6.1 | 9.8e-10 | 0.36 | 0.20 | 0.22 | FALSE |
| 6 | GTEx | Skin Sun Exposed Lower leg | RP11-385F7.1 | 0.09 | 0.05 | enet | 6 | 0.05 | 6.1e-05 | 6.0 | -6.1 | 1.2e-09 | 0.43 | 0.26 | 0.45 | FALSE |
| 7 | GTEx | Thyroid | RP11-385F7.1 | 0.23 | 0.20 | lasso | 3 | 0.19 | 2.0e-14 | 6.0 | -5.7 | 1.5e-08 | 0.30 | 0.92 | 0.08 | FALSE |
| 8 | The Cancer Genome Atlas | Breast Invasive Carcinoma | GPR111 | 0.03 | 0.01 | lasso | 2 | 0.02 | 2.5e-05 | -6.2 | 7.6 | 2.2e-14 | -0.64 | 0.23 | 0.64 | TRUE |
| 9 | The Cancer Genome Atlas | Esophageal Carcinoma | GPR111 | 0.19 | 0.14 | lasso | 2 | 0.14 | 3.9e-05 | -6.1 | 6.3 | 3.5e-10 | -0.86 | 0.27 | 0.59 | FALSE |
| 10 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | GPR111 | 0.10 | 0.16 | enet | 17 | 0.16 | 9.4e-18 | -6.1 | 5.9 | 3.9e-09 | -0.78 | 0.51 | 0.49 | FALSE |
| 11 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | GPR115 | 0.06 | 0.11 | lasso | 8 | 0.13 | 2.5e-14 | -6.1 | 5.3 | 1.1e-07 | -0.77 | 0.04 | 0.96 | FALSE |
| 12 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | GPR111 | 0.04 | 0.08 | lasso | 1 | 0.05 | 6.7e-04 | -6.1 | 6.1 | 1.0e-09 | -0.81 | 0.23 | 0.25 | FALSE |
| 13 | The Cancer Genome Atlas | Stomach Adenocarcinoma | GPR111 | 0.03 | 0.04 | lasso | 1 | 0.03 | 2.4e-03 | -6.0 | 6.0 | 1.5e-09 | -0.80 | 0.21 | 0.40 | FALSE |
| 14 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | GPR115 | 0.08 | 0.09 | blup | 90 | 0.06 | 3.4e-03 | -4.2 | 5.3 | 1.4e-07 | -0.71 | 0.09 | 0.64 | FALSE |