Best TWAS P=7.44e-26 · Best GWAS P=2.93e-32 conditioned to 3.15e-09
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | SENP6 | 0.08 | 0.00 | enet | 5 | 0.00 | 8.2e-01 | 10.3 | 10.5 | 7.4e-26 | 0.76 | 0.04 | 0.46 | TRUE |
| 3 | GTEx | Skin Not Sun Exposed Suprapubic | MYO6 | 0.11 | 0.03 | lasso | 3 | 0.04 | 2.1e-03 | 10.3 | -8.9 | 5.7e-19 | -0.70 | 0.15 | 0.46 | FALSE |
| 4 | METSIM | Adipose | COL12A1 | 0.04 | 0.01 | blup | 309 | 0.02 | 5.1e-04 | -1.0 | -6.7 | 2.1e-11 | -0.48 | 0.12 | 0.53 | FALSE |
| 8 | The Cancer Genome Atlas | Prostate Adenocarcinoma | MYO6 | 0.04 | 0.03 | blup | 105 | 0.05 | 7.0e-06 | -5.4 | -6.5 | 5.6e-11 | -0.23 | 0.67 | 0.02 | FALSE |
| 7 | The Cancer Genome Atlas | Lung Adenocarcinoma | IMPG1 | 0.05 | 0.03 | lasso | 2 | 0.02 | 2.4e-03 | 6.4 | 6.5 | 1.1e-10 | 0.59 | 0.00 | 0.98 | FALSE |
| 2 | GTEx | Muscle Skeletal | FILIP1 | 0.04 | 0.00 | enet | 13 | 0.01 | 1.6e-02 | 10.5 | -6.1 | 1.2e-09 | -0.59 | 0.15 | 0.10 | FALSE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | MYO6 | 0.09 | 0.07 | enet | 27 | 0.08 | 4.1e-10 | 3.3 | -5.8 | 8.1e-09 | -0.40 | 1.00 | 0.00 | FALSE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | SENP6 | 0.17 | 0.14 | blup | 355 | 0.17 | 2.5e-21 | -1.5 | -5.1 | 2.8e-07 | -0.41 | 1.00 | 0.00 | FALSE |