TWAS
hub
About
Usage
Models
Genes
Traits
[Hub]/) :
Traits
:
Maternal smoking around birth
:
←
→
chr14:103,342,049-104,866,687
Best TWAS P=4.31e-08 · Best GWAS P=1.71e-06 conditioned to 0.679
103.4M
103.6M
103.8M
104M
104.2M
104.4M
104.6M
104.8M
0
1
2
3
4
5
6
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
3
YFS
Blood
KLC1
0.01
0.01
blup
389
0.01
1.0e-03
-4.4
5.5
4.3e-08
-0.83
0.03
0.87
TRUE
1
GTEx
Breast Mammary Tissue
KLC1
0.12
0.02
enet
26
0.07
2.9e-04
4.1
5.3
1.2e-07
-0.67
0.14
0.74
FALSE
2
GTEx
Muscle Skeletal
KLC1
0.11
0.07
lasso
7
0.08
3.3e-08
-4.7
5.3
1.5e-07
-0.91
0.02
0.96
FALSE
5
The Cancer Genome Atlas
Lung Squamous Cell Carcinoma
CKB
0.03
0.00
blup
34
0.02
1.4e-03
4.2
-5.2
1.5e-07
0.71
0.01
0.33
FALSE
4
The Cancer Genome Atlas
Brain Lower Grade Glioma
C14orf153
0.04
0.01
blup
38
0.03
6.2e-04
4.2
-5.2
1.8e-07
0.79
0.01
0.52
FALSE