TWAS
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About
Usage
Models
Genes
Traits
[Hub]/) :
Traits
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Maternal smoking around birth
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chr15:78,592,277-79,129,823
Best TWAS P=7.72e-11 · Best GWAS P=2.65e-12 conditioned to 0.0093
78.6M
78.7M
78.8M
78.9M
79M
79.1M
0
2
4
6
8
10
12
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
3
The Cancer Genome Atlas
Pheochromocytoma and Paraganglioma
CHRNA5
0.15
0.07
blup
50
0.09
0.00025
-6.7
-6.5
7.7e-11
0.95
0.01
0.97
TRUE
1
The Cancer Genome Atlas
Liver Hepatocellular Carcinoma
PSMA4
0.08
0.02
blup
40
0.03
0.01120
-4.6
-6.2
7.0e-10
0.83
0.02
0.57
FALSE
2
The Cancer Genome Atlas
Ovarian Serous Cystadenocarcinoma
CHRNA5
0.03
0.01
enet
4
0.03
0.00206
3.2
5.1
2.6e-07
-0.77
0.04
0.69
FALSE