Hub : Genes

PSMA4

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0760	0.0220	2.8e-06	0.058	0.054	0.063	0.059	0.070	1.3e-07	3.9e-07	3.5e-08	1.1e-07	7.0e-09
2	GTEx	Heart Left Ventricle	0.1753	0.0613	1.6e-04	0.019	NA	0.059	NA	0.055	3.4e-02	NA	4.4e-04	NA	6.4e-04
3	GTEx	Liver	0.1850	0.0770	5.2e-03	0.139	NA	0.046	NA	0.107	1.1e-04	NA	2.0e-02	NA	6.5e-04
4	GTEx	Muscle Skeletal	0.1006	0.0299	7.7e-07	0.062	NA	0.099	NA	0.090	1.1e-06	NA	6.7e-10	NA	3.9e-09
5	GTEx	Nerve Tibial	0.0880	0.0383	3.4e-03	0.047	NA	0.013	NA	0.029	3.0e-04	NA	3.8e-02	NA	3.8e-03
6	METSIM	Adipose	0.0787	0.0238	8.9e-07	0.028	0.037	0.021	0.035	0.026	3.4e-05	2.6e-06	3.8e-04	4.5e-06	7.7e-05
7	YFS	Blood	0.0775	0.0156	0.0e+00	0.079	0.096	0.104	0.110	0.113	1.7e-24	7.9e-30	3.7e-32	4.7e-34	8.3e-35
8	TCGA	Liver Hepatocellular Carcinoma	0.0830	0.0480	4.2e-03	0.023	0.033	0.025	NA	0.020	2.8e-02	1.1e-02	2.3e-02	NA	4.0e-02
9	TCGA	Lung Squamous Cell Carcinoma	0.0253	0.0186	6.8e-03	0.015	0.018	0.005	NA	0.012	6.4e-03	3.1e-03	7.7e-02	NA	1.5e-02
10	TCGA	Testicular Germ Cell Tumors	0.1060	0.0620	1.8e-03	0.010	0.030	-0.003	NA	0.009	1.3e-01	3.0e-02	4.2e-01	NA	1.5e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	1.4	2.2	4.8	2.2	0.0	1.2	-1.5	-1.0	-1.9	2.1	-2.1	0.2	-0.4
Bipolar Disorder or Schizophrenia	6.7	16.2	40.8	4.9	1.5	4.7	-3.7	-1.6	-4.0	6.4	-6.2	1.5	0.2
Depressed Affect (Nagel 2018)	0.6	1.4	2.7	-1.2	0.7	1.3	1.1	1.4	1.3	0.6	-0.1	1.3	1.6
Depression (Nagel 2018)	0.4	0.6	2.7	-0.2	0.3	1.7	0.2	0.8	0.3	1.0	-0.7	0.7	0.7
Intelligence (Savage-Jansen 2018)	1.1	3.4	5.9	2.4	-0.9	-1.3	-2.0	-2.2	-2.1	-0.2	-1.4	-2.3	-2.2
Neuroticism (Nagel 2018)	0.0	0.1	0.2	-0.5	-0.2	0.4	0.3	0.2	0.4	-0.1	0.1	0.2	0.4
Schizophrenia (2018)	7.8	16.2	42.4	4.7	1.8	5.1	-3.5	-1.2	-3.5	6.5	-6.2	1.9	0.7
Schizophrenia vs Biploar Disorder	0.4	0.5	1.5	1.2	0.7	0.8	-0.6	-0.4	-0.2	1.1	-0.7	0.6	-0.2
Worry (Nagel 2018)	0.4	0.9	2.8	0.5	0.1	1.5	-0.6	-0.2	-0.2	1.6	-1.7	0.5	0.6
Alzheimer’s Disease (in mother)	0.8	1.0	1.8	0.1	0.9	1.2	0.7	1.0	-1.4	1.2	-0.8	1.0	1.0
Alzheimer’s Disease (in father)	0.2	0.3	0.7	0.3	-0.3	0.7	-0.1	0.3	0.8	0.6	0.1	0.8	0.4
Alzheimer’s Disease (including proxy)	0.1	0.2	1.2	0.2	-0.5	-0.3	0.0	-0.1	-1.1	0.0	-0.0	-0.2	-0.1
Crohns Disease (2017)	0.2	0.3	1.6	-0.0	1.2	0.4	0.3	0.3	-0.9	0.3	-0.4	0.3	0.5
Irritable Bowel Disease (IBD)	0.0	0.1	0.4	-0.2	0.4	-0.0	0.4	0.1	-0.6	-0.3	0.1	-0.2	0.2
Ulcerative Colitis (UC)	0.3	0.6	1.5	0.2	-1.2	-0.8	-0.2	-0.8	-0.9	-0.9	0.5	-1.0	-0.9
Major Depression (MDD)	0.3	0.4	1.5	1.2	-0.1	-0.2	-0.9	-0.8	-0.4	0.2	-0.2	-0.4	-0.8
Reaction Time	4.8	9.2	16.5	-3.0	2.7	2.9	3.5	4.1	3.1	1.0	0.6	3.5	4.0
Verbal and Numeric Reasoning (VNR)	0.3	0.7	1.3	0.9	0.1	-0.4	-1.1	-0.9	-1.1	-0.2	-0.7	-1.2	-1.0
Breast Cancer	0.4	0.9	1.9	0.6	-1.1	-0.9	-0.9	-1.3	0.0	-0.9	0.1	-1.4	-1.2
Ovarian Cancer	1.3	1.8	3.9	0.2	-2.0	-1.9	-1.0	-1.6	0.2	-1.2	-0.1	-1.9	-1.2
Prostate Cancer	2.2	3.0	5.2	0.9	-2.0	-1.8	-1.6	-2.0	-2.3	-1.1	0.5	-2.0	-2.3
Age at First Birth	0.5	0.7	1.7	-1.3	0.3	-0.3	1.2	1.0	0.6	-0.9	0.7	0.3	0.7
Bipolar Disorder (2011)	0.5	0.5	1.5	-0.2	0.0	1.0	0.1	0.5	0.4	1.0	-0.3	1.2	1.0
Body Mass Index (BMI) (2010)	1.7	2.4	7.0	-1.3	-2.7	-1.9	0.5	-0.4	1.4	-2.1	1.7	-1.1	-0.9
Coronary Artery Disease (CAD)	0.5	0.6	2.1	1.2	-0.4	0.7	-0.8	-0.7	0.4	0.4	-1.4	-0.1	-0.2
Crohns Disease (2012)	0.1	0.2	0.7	0.4	0.8	0.5	0.3	0.4	-0.3	0.4	-0.3	0.3	0.4
Mean Putamen Volume	0.4	0.5	1.1	-0.7	0.8	0.7	0.9	0.8	0.6	0.0	-0.2	0.5	1.1
Fasting Glucose	0.6	0.7	1.9	1.4	-1.0	0.4	-0.7	-0.7	-1.1	1.0	-0.9	-0.2	-0.4
HbA1C	0.9	1.0	3.3	0.5	0.6	1.5	-0.4	0.3	0.6	1.8	-1.6	0.5	0.8
HDL Cholesterol	1.0	1.6	3.8	-0.2	-1.3	-1.9	-0.3	-0.9	-0.7	-1.9	1.3	-1.5	-1.2
LDL Cholesterol	1.5	2.3	7.9	0.6	1.7	1.7	-0.7	0.2	-1.6	2.2	-2.8	0.4	1.0
Lupus	0.2	0.3	0.8	-0.3	0.9	-0.8	0.1	-0.1	-0.6	-0.6	0.7	-0.2	-0.2
Neuroticism (2016)	0.5	0.8	1.9	1.4	-1.2	0.8	-0.7	-0.6	-0.7	1.1	-1.1	-0.0	-0.4
Primary Biliary Cirrhosis	0.1	0.1	0.2	-0.4	-0.1	0.4	0.5	0.3	-0.3	0.1	-0.1	0.0	0.5
Rheumatoid Arthritis	0.6	0.9	1.6	0.5	-1.0	-1.0	-0.9	-1.1	-1.0	-0.6	-0.7	-1.3	-0.9
Schizophrenia (2014)	5.1	11.2	27.7	4.3	1.3	4.2	-3.2	-1.4	-2.7	5.3	-5.0	1.4	0.3
Triglycerides	1.2	2.0	4.0	-0.6	1.5	1.8	1.0	1.6	0.4	1.5	-1.6	1.4	2.0
Type 2 Diabetes (T2D) (2012)	2.6	3.0	7.6	1.6	-2.8	-1.6	-1.6	-1.7	-1.0	-0.9	0.0	-2.2	-2.4
Ulcerative Colitis	0.2	0.4	1.2	0.7	-0.9	0.5	-0.4	-0.3	0.1	1.1	-0.7	0.3	-0.1
Blood Eosinophil Count	0.0	0.3	1.0	-0.8	1.0	-0.3	0.6	0.2	-0.3	-0.6	0.5	-0.2	0.2
Blood Platelet Count	0.1	1.6	5.9	-1.2	1.5	0.4	2.4	1.9	-0.4	-0.4	0.1	0.4	1.3
Blood Red Count	0.8	7.5	23.6	0.2	-4.9	-3.7	-0.9	-2.2	0.1	-2.9	2.7	-2.6	-3.1
Blood White Count	0.4	3.3	9.1	2.1	0.6	2.1	-0.5	0.2	-2.1	3.0	-3.0	0.7	0.5
Heel T-Score	0.0	0.4	1.0	0.5	-0.3	1.0	0.2	0.5	-0.1	1.0	-0.9	0.4	0.2
BMI	0.5	3.2	10.6	1.7	-3.3	-1.4	-1.4	-1.6	-2.2	-0.3	0.1	-1.6	-2.1
Height	0.1	1.2	2.4	0.2	-0.5	-1.5	-1.1	-1.3	0.6	-1.4	1.6	-0.5	-1.1
Waist Hip Ratio (WHR)	0.5	2.1	4.8	-0.4	1.6	1.4	1.2	1.5	1.0	1.8	-2.2	0.7	1.9
Systolic Blood Pressure	0.1	0.3	1.0	0.7	0.3	0.5	-1.0	-0.3	0.8	0.5	0.2	0.2	-0.7
Smoking Status	3.1	7.5	12.5	2.4	-2.3	-2.8	-2.9	-3.5	-3.2	-1.2	-0.8	-3.3	-3.4
Allergy or Eczema	2.0	5.4	16.2	-2.1	-2.0	-3.2	1.1	-0.2	0.5	-4.0	3.5	-1.8	-1.3
Cardiovascular Disease	0.3	1.0	2.7	0.5	1.4	1.4	-0.5	0.4	-0.3	1.6	-1.4	0.8	0.8
Hypothyroidism (self reported)	0.8	1.9	5.0	-0.8	0.9	1.6	0.8	1.5	1.5	1.1	-0.3	2.2	1.9
Respiratory disease	0.9	1.9	4.6	-2.1	0.9	1.0	2.1	1.8	0.3	-0.0	0.2	1.1	2.0
Type 2 Diabetes (T2D) (2018)	0.4	0.7	2.5	1.1	0.4	0.8	-0.4	-0.3	-1.0	1.3	-1.6	-0.2	-0.0
Lung FEV1/FVC ratio	3.0	15.1	37.9	-1.5	-3.1	-6.2	0.5	-2.1	1.6	-5.9	5.3	-4.2	-3.7
Lung FVC	3.5	17.8	41.0	-0.1	-4.2	-6.4	-1.5	-3.7	-1.3	-6.0	3.2	-5.7	-4.8
Neuroticism	0.9	2.1	3.8	-1.4	1.2	1.7	1.4	1.7	1.8	0.8	-0.4	1.4	1.9
Chronotype (morning person)	1.1	2.5	6.8	-0.2	-1.3	-2.6	0.1	-1.2	-0.4	-2.5	1.5	-2.0	-1.5
Hair Pigment	0.1	1.7	3.7	-1.9	-0.2	-0.8	1.8	1.2	1.7	-1.1	1.7	0.6	0.8
Tanning	0.0	0.3	0.5	0.5	-0.4	-0.6	-0.7	-0.5	-0.7	0.2	-0.2	-0.5	-0.4
Hand grip strength (left)	0.4	1.1	3.2	-0.4	0.7	1.7	0.6	1.2	0.3	0.8	-0.2	1.8	1.3
Number of treatments/medications taken	0.9	1.5	4.3	1.7	-1.2	0.9	-1.1	-0.5	-1.0	1.8	-2.1	0.1	-0.1
Average weekly spirits intake	1.9	2.3	6.4	-0.8	-1.6	-2.5	0.0	-1.1	-0.2	-2.3	1.1	-2.1	-1.4
Sensitivity / hurt feelings	0.3	0.5	1.7	0.4	-1.3	-0.6	-0.7	-0.6	-0.3	-0.7	0.7	-0.6	-0.9
Frequency of depressed mood in last 2 weeks	0.3	0.5	1.6	0.8	-0.4	1.1	-0.5	-0.1	0.1	1.2	-0.8	0.1	-0.2
Hearing difficulty/problems: Yes	0.7	1.0	3.1	-1.3	-0.8	-1.0	1.2	0.7	0.7	-1.3	1.8	-0.0	-0.1
Relative age of first facial hair	0.4	0.8	2.2	-0.1	-1.0	-1.5	-0.4	-0.6	0.8	-1.4	0.9	-1.0	-0.8
Other serious medical condition/disability diagnosed by doctor	1.2	1.6	4.3	1.6	0.6	1.5	-1.1	-0.3	-0.8	2.1	-1.9	0.6	0.2
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.4	0.1	-0.6	0.2	0.0	0.3	-0.6	0.4	0.4	0.3	-0.0
Ever had hysterectomy (womb removed)	0.3	0.4	1.2	-0.3	1.1	-0.3	0.6	0.1	-0.8	-0.6	0.8	0.4	0.1
Systolic blood pressure, automated reading	0.1	0.3	1.0	-0.1	-1.0	-0.4	-0.5	-0.3	0.6	-0.4	0.2	-0.7	-0.9
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	1.0	0.5	-0.2	0.2	-0.1	-0.0	-1.0	0.5	-0.5	-0.1	0.1
Angina	3.5	4.6	12.1	0.6	-3.0	-3.1	-0.5	-1.6	-0.1	-2.5	0.6	-3.5	-2.3
Medication for hormone replacement therapy	0.5	0.6	1.8	-0.1	-0.7	0.9	0.2	0.5	1.4	0.9	-0.4	0.9	0.8
Vitamin and mineral supplements	2.9	3.9	9.0	-0.2	2.0	3.0	1.0	1.9	-0.4	2.7	-1.6	2.6	2.3
Supplements: Zinc	5.2	5.7	9.6	3.1	-1.4	-1.6	-3.1	-3.0	-2.9	0.1	-1.4	-2.4	-2.8
Medication: Co-codamol	1.5	1.8	4.4	2.1	-1.1	0.1	-1.3	-1.2	-1.3	1.3	-2.0	-1.0	-0.9
Medication: Metformin	0.3	0.4	1.6	0.6	-0.6	0.0	-0.6	-0.5	-1.3	0.4	-0.7	-0.2	-0.3
Diabetes (father)	1.0	1.3	3.8	-1.6	0.4	0.0	2.0	1.2	0.8	-1.3	1.3	0.5	0.8
Diabetes (mother)	1.8	2.3	5.4	0.6	-2.3	-2.0	-0.9	-1.5	-0.3	-1.5	0.3	-2.2	-1.8
Severe depression (siblings)	0.5	0.5	1.8	1.4	0.2	-0.1	-0.9	-0.9	-0.6	0.3	0.3	-0.3	-1.1
Pack years adult smoking proportion	87.3	133.2	327.6	2.8	11.5	18.1	-0.1	7.0	-1.5	18.1	-13.3	13.3	11.5
Impedance of leg (right)	0.4	1.7	3.8	-1.9	1.0	0.5	1.5	1.7	1.6	-0.2	0.5	0.9	1.8
Leg fat-free mass (left)	0.7	3.5	6.2	2.4	-2.3	-1.0	-2.3	-2.5	-1.9	0.0	-0.2	-1.4	-2.4
Trunk fat percentage	0.6	2.5	15.2	0.4	-3.9	-1.8	-0.2	-0.8	-0.8	-1.1	0.7	-1.4	-1.3
Hand grip strength (right)	0.1	0.2	0.4	0.6	-0.5	0.7	-0.4	0.1	-0.6	0.2	0.1	0.5	-0.1
Townsend deprivation index at recruitment	2.0	2.9	8.0	2.3	0.1	1.1	-2.2	-1.4	-1.2	2.4	-2.8	-0.4	-0.5
Current tobacco smoking	4.0	6.6	16.0	3.4	1.1	2.2	-2.8	-1.7	-2.9	3.5	-4.0	-0.2	-0.8
Average weekly fortified wine intake	1.2	1.4	3.6	-1.0	1.2	1.0	1.1	1.2	1.9	0.8	-0.4	1.1	1.4
Maternal smoking around birth	9.3	13.4	38.0	4.8	-1.3	3.0	-4.4	-2.2	-3.5	5.0	-6.2	0.1	-1.0
Fed-up feelings	0.7	1.2	3.2	-0.2	0.2	1.8	0.6	1.2	0.1	1.5	-0.8	1.4	1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	1.9	2.5	8.0	1.4	1.1	2.0	-1.2	-0.3	-0.8	2.6	-2.8	0.3	0.4
Relative age voice broke	0.3	0.4	1.8	-0.8	-0.2	-0.5	0.3	0.4	0.6	-0.6	1.3	0.5	0.1
Taking other prescription medications	2.5	3.9	9.6	3.1	-1.3	0.8	-2.7	-1.8	-2.2	2.1	-2.0	-0.8	-1.4
Age when periods started (menarche)	1.9	4.6	12.1	-0.6	-2.4	-3.2	0.5	-1.4	0.2	-3.5	1.6	-2.8	-2.2
Bilateral oophorectomy (both ovaries removed)	4.1	4.7	9.5	1.1	-1.4	-3.0	-1.9	-2.4	-1.6	-2.1	1.6	-2.6	-3.1
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	2.0	0.6	0.3	1.4	-0.1	0.4	0.3	1.1	-0.9	0.6	0.4
Tinnitus: Yes, but not now, but have in the past	1.9	2.0	4.8	2.0	0.2	-0.3	-2.2	-1.6	-1.9	0.8	-0.9	-1.1	-1.6
Qualifications: CSEs or equivalent	2.3	3.1	9.3	1.1	0.9	2.8	-1.1	0.3	0.4	3.1	-2.3	1.8	1.3
Serious illness, injury or assault to yourself	1.7	2.1	4.1	2.0	-0.6	-0.6	-2.0	-1.8	-2.0	0.3	-0.7	-1.1	-1.7
High blood pressure	0.3	0.7	2.4	1.1	0.5	1.0	-0.8	-0.1	-0.9	1.6	-0.5	0.8	-0.1
Hayfever, allergic rhinitis or eczema	1.6	3.6	10.9	-1.4	-1.6	-2.5	0.8	-0.2	0.3	-3.3	2.9	-1.6	-1.4
Multivitamins +/- minerals	3.4	4.3	10.0	-0.3	-1.8	-3.2	-0.4	-1.5	1.2	-3.1	2.7	-2.2	-2.1
Stomach or abdominal pain in last month	0.8	1.0	4.1	1.3	-2.0	-0.1	-0.9	-0.9	-0.6	0.5	-1.0	-0.4	-0.6
Supplements: Glucosamine	1.3	1.7	4.7	-0.4	-0.6	-2.1	-0.3	-1.0	0.6	-2.2	1.0	-1.8	-1.5
Diverticular disease/diverticulitis (self-reported)	1.2	1.4	4.6	-1.1	0.7	0.6	0.9	0.9	2.1	0.3	0.7	1.8	1.2
Medication: Atenolol	1.5	1.9	5.1	1.0	-2.3	-1.6	-0.7	-1.1	-0.9	-1.3	0.5	-1.6	-1.7
Medication: Levothyroxine sodium	0.3	0.4	1.1	-0.1	0.1	0.9	-0.2	0.3	1.0	0.8	-0.7	0.8	0.7
Sitting height	0.5	3.5	7.7	1.0	-1.4	-2.8	-1.2	-2.1	-0.3	-2.2	2.3	-1.5	-2.4
Chronic bronchitis/emphysema (father)	17.0	19.9	49.8	1.0	3.9	6.9	-0.0	2.7	-1.3	7.1	-5.8	4.7	4.5
High blood pressure (mother)	0.5	0.7	1.9	-1.4	0.8	-0.7	0.5	0.3	1.4	-0.9	0.9	-0.2	0.3
Body mass index (BMI)	0.6	2.4	11.1	1.6	-3.3	-0.6	-1.0	-1.3	-2.0	0.3	-0.4	-1.1	-1.6
Impedance of leg (left)	0.7	3.2	6.8	-2.6	1.4	0.5	2.2	2.5	2.0	-0.5	0.6	1.2	2.4
Leg predicted mass (left)	0.6	3.2	5.6	2.3	-2.2	-0.9	-2.2	-2.4	-1.8	0.1	-0.2	-1.2	-2.3
Trunk fat mass	0.6	2.8	14.5	0.8	-3.8	-1.7	-0.7	-1.2	-1.1	-1.0	0.6	-1.5	-1.6
Waist circumference	0.8	2.8	11.0	1.8	-3.3	-0.8	-1.2	-1.4	-1.9	0.5	-0.8	-1.4	-1.7
Number of incorrect matches in round	2.4	3.9	8.2	-1.6	1.3	2.3	2.1	2.6	0.9	1.5	-0.5	2.7	2.9
Past tobacco smoking	2.3	4.1	7.2	-1.9	1.6	2.2	2.3	2.7	2.3	0.9	0.8	2.4	2.3
Alcohol usually taken with meals	1.8	2.9	11.9	-1.7	0.5	-1.9	1.1	0.6	1.4	-2.6	3.5	-0.3	-0.3
Nervous feelings	0.8	1.6	4.2	0.5	0.6	2.1	-0.1	0.4	-0.4	2.0	-1.8	1.4	1.1
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.2	4.1	1.0	-0.3	2.0	-0.4	0.2	0.2	2.0	-1.4	0.7	0.3
Hearing difficulty/problems with background noise	1.3	2.1	4.9	-1.8	-1.0	-1.9	1.6	0.5	0.6	-2.2	2.1	-0.5	-0.2
Hair/balding pattern: Pattern 2	0.4	0.5	1.4	1.0	0.1	0.5	-1.0	-0.5	-1.2	-0.0	0.5	0.1	-0.8
Had menopause	0.5	0.6	2.3	0.6	0.7	1.0	-0.6	-0.0	-0.1	1.5	-1.2	0.6	0.4
Had other major operations	1.5	1.8	4.1	1.3	-1.1	-1.6	-1.3	-2.0	-0.5	-0.6	-0.0	-1.6	-1.9
Forced vital capacity (FVC)	2.7	10.5	26.7	-0.8	-3.0	-5.2	-0.6	-2.6	0.2	-5.1	3.6	-3.5	-3.2
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	1.8	1.2	0.1	0.9	-0.9	-0.4	-0.6	1.2	-1.3	-0.1	-0.3
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.5	0.5	0.6	0.7	-0.5	-0.3	0.3	0.7	-0.1	0.7	-0.0
Qualifications: None of the above	1.2	2.6	6.5	-0.6	-2.4	-2.6	0.4	-0.6	0.9	-2.2	1.9	-1.5	-1.3
Financial difficulties in last 2 years	1.7	2.3	4.5	0.8	-2.0	-2.1	-1.2	-1.9	-0.3	-1.0	0.5	-1.8	-2.1
Mouth/teeth dental problems	1.7	2.6	6.6	-2.0	-0.1	-2.1	1.0	0.2	1.6	-2.6	2.5	-1.0	-0.2
Heart attack	0.1	0.2	0.8	0.4	-0.4	0.6	0.1	0.1	0.1	0.3	-0.9	-0.2	0.2
Allergy	0.5	1.2	3.6	1.3	0.9	1.2	-0.8	-0.2	-0.9	1.9	-1.3	0.9	0.4
Pain all over the body in last month	1.6	1.7	4.3	1.7	-0.7	1.4	-1.4	-0.4	-0.9	2.1	-2.0	0.3	-0.2
Diabetes (self-reported)	0.1	0.1	0.3	0.3	-0.4	0.4	-0.1	-0.2	-0.4	0.4	-0.6	0.1	-0.0
Hayfever/allergic rhinitis (self-reported)	2.6	3.4	7.3	0.2	-2.2	-2.6	-0.6	-1.8	-1.2	-2.7	0.7	-2.7	-1.8
Medication: Ramipril	0.3	0.3	1.7	0.7	-0.4	0.4	-0.2	0.2	-1.3	0.7	-0.1	0.5	-0.2
Medication: Simvastatin	1.0	1.4	4.8	0.9	-0.4	1.2	-0.6	0.1	-1.7	1.8	-2.2	0.7	0.6
Fluid intelligence score	0.4	0.9	2.1	1.1	1.1	0.2	-1.0	-0.7	-1.5	0.6	-1.3	-0.6	-0.4
Illnesses of siblings	0.6	0.8	2.5	-0.9	-0.7	-1.3	0.3	-0.2	0.9	-1.6	1.3	-0.5	-0.2
Neuroticism score	0.5	1.1	3.2	0.0	0.4	1.8	0.3	0.7	1.1	1.5	-0.9	1.2	1.1
Weight	0.6	2.9	10.6	1.7	-3.3	-1.3	-1.4	-1.8	-1.7	-0.3	0.3	-1.3	-2.0
Impedance of arm (right)	0.1	0.6	2.5	-1.1	0.4	-0.0	0.5	0.7	1.6	-0.2	-0.2	0.3	1.1
Arm fat percentage (right)	0.4	1.7	10.7	1.0	-3.3	-0.7	-0.6	-0.9	-1.5	0.1	-0.3	-0.9	-1.0
Trunk fat-free mass	0.3	1.7	3.7	1.8	-1.0	-0.7	-1.8	-1.9	-1.4	-0.1	0.1	-0.9	-1.8
Hip circumference	1.0	4.3	14.4	2.2	-3.8	-1.4	-1.9	-2.2	-2.4	-0.3	0.1	-1.4	-2.4
Time employed in main current job	0.4	0.4	0.9	-0.7	-0.8	-0.3	0.7	0.5	1.0	-0.8	0.7	0.2	0.2
Alcohol intake versus 10 years previously	0.8	1.2	4.7	1.2	-2.2	-0.8	-0.5	-0.9	-1.2	-0.2	-0.3	-1.1	-1.1
Father’s age at death	13.4	18.0	46.2	-1.2	-4.7	-6.8	0.3	-2.3	-0.2	-6.5	5.4	-4.1	-4.0
Worrier / anxious feelings	0.8	1.5	4.1	1.5	-0.3	1.7	-1.3	-0.5	0.3	2.0	-1.9	0.5	0.1
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.7	3.3	1.4	-1.8	0.7	-1.6	-1.2	-1.4	1.5	-1.4	-0.3	-0.8
Falls in the last year	5.4	7.3	12.8	3.4	-3.4	-2.1	-3.4	-3.6	-1.8	-0.2	-0.2	-2.5	-3.6
Hair/balding pattern: Pattern 3	1.7	2.5	4.2	-2.0	1.8	0.9	1.9	2.0	1.8	-0.0	0.7	1.4	1.9
Number of live births	2.9	4.1	11.2	-2.1	-2.3	-2.4	1.3	0.3	0.6	-3.2	3.4	-1.0	-0.9
Forced expiratory volume in 1-second (FEV1)	5.1	17.2	45.2	-1.5	-3.8	-6.5	0.0	-2.5	0.7	-6.7	5.3	-4.2	-3.8
Pulse rate	0.6	1.1	2.3	-0.8	0.3	1.4	1.0	1.2	-0.0	1.0	-0.1	1.5	1.5
Happiness	0.5	0.6	1.6	-1.0	-0.3	0.5	0.9	0.9	1.3	-0.1	0.3	0.9	0.8
Noisy workplace	0.1	0.2	0.5	0.7	-0.5	0.4	-0.4	-0.3	-0.5	0.4	-0.0	-0.1	-0.3
Qualifications: A levels/AS levels or equivalent	1.6	3.6	6.6	-2.4	2.6	0.1	2.2	1.9	2.5	-0.9	1.3	1.4	2.1
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	2.0	1.4	-0.9	-0.7	-0.8	-1.0	0.0	-0.1	-0.0	-0.7	-1.2
Mouth/teeth dental problems: Dentures	4.7	8.0	23.2	1.7	1.9	4.4	-0.6	1.1	-1.5	4.8	-3.7	3.0	2.0
Asthma	0.9	1.8	4.5	-2.1	-1.0	0.2	2.1	1.7	0.7	-0.8	1.3	0.8	1.2
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	2.5	-0.8	-1.6	-1.1	0.6	-0.2	1.3	-1.3	1.3	-0.6	-0.3
Medication: Cholesterol lowering	0.9	1.4	4.3	1.4	-0.1	0.7	-1.0	-0.5	-2.1	1.4	-2.1	-0.3	-0.2
Depression (self-reported)	1.4	1.7	5.3	1.1	1.0	1.8	-0.7	0.3	-1.1	2.3	-1.5	0.9	0.9
Medication: Lansoprazole	1.0	1.2	4.0	1.1	0.1	1.5	-0.9	-0.2	-0.8	1.7	-2.0	0.4	0.3
Prospective memory result	1.1	1.3	3.0	-1.4	-0.3	-0.9	1.3	0.9	1.7	-1.5	1.6	-0.0	0.5
Lung cancer (father)	20.2	23.7	68.2	2.2	3.0	7.9	-1.1	2.3	-1.1	8.3	-6.2	5.5	4.1
Illnesses of mother	0.4	0.5	2.0	-0.8	-0.4	-0.9	0.6	-0.1	0.6	-1.4	0.9	-0.5	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	6.4	20.3	49.5	-0.8	-4.7	-7.0	-1.0	-3.4	0.2	-6.8	4.9	-5.1	-4.7
Pulse wave Arterial Stiffness index	0.5	0.6	2.7	1.1	-1.7	0.0	-0.6	-0.8	-0.4	0.3	-0.2	-0.4	-0.9
Impedance of arm (left)	0.2	0.8	2.7	-1.6	0.4	-0.4	0.7	0.7	1.6	-0.7	0.4	0.2	1.0
Arm fat mass (right)	0.5	2.0	10.7	1.1	-3.3	-1.0	-0.8	-1.1	-1.6	-0.2	0.1	-1.0	-1.3
Trunk predicted mass	0.3	1.6	3.5	1.7	-0.9	-0.7	-1.8	-1.9	-1.4	-0.1	0.1	-0.8	-1.7
Standing height	0.2	1.5	4.2	0.0	-0.5	-2.0	-0.8	-1.2	0.6	-1.7	1.8	-0.7	-1.3
Length of working week for main job	0.9	1.0	3.0	-0.3	-1.1	-0.7	0.2	-0.3	1.6	-1.6	1.7	-0.3	-0.8
Exposure to tobacco smoke at home	2.5	2.8	7.1	-1.0	-1.5	-2.5	0.3	-0.9	-0.7	-2.7	2.0	-1.9	-1.7
Breastfed as a baby	0.4	0.5	0.9	0.9	0.1	-0.8	-0.8	-0.9	-0.8	-0.4	-0.3	-0.7	-0.8
Tense / ‘highly strung’	0.1	0.1	0.5	-0.3	-0.7	-0.1	0.1	-0.0	0.6	-0.1	0.2	-0.1	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.0	2.6	1.1	0.3	1.5	-0.7	-0.3	-1.4	1.6	-1.1	0.7	0.2
Hair/balding pattern: Pattern 4	0.1	0.2	0.7	-0.7	-0.5	-0.1	0.8	0.7	0.1	0.1	-0.3	-0.0	0.6
Birth weight of first child	1.1	1.9	4.0	1.1	-1.2	-1.6	-0.9	-1.2	-2.0	-1.1	1.5	-1.1	-1.8
Peak expiratory flow (PEF)	2.3	5.3	15.5	-1.5	-2.4	-3.3	0.6	-0.6	0.6	-3.9	3.5	-1.8	-1.5
Pulse wave reflection index	0.2	0.2	0.6	0.7	-0.0	0.8	-0.2	-0.1	0.4	0.7	-0.1	0.7	-0.1
Ever highly irritable/argumentative for 2 days	1.1	1.3	3.3	-1.8	0.7	-0.2	1.7	1.4	1.1	-0.6	1.1	0.6	1.0
Loud music exposure frequency	1.8	2.0	4.9	0.6	-1.7	-1.8	-0.8	-1.5	-1.1	-1.3	0.2	-2.2	-1.7
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.5	0.7	0.5	0.7	-0.8	-0.2	-0.3	1.0	-1.2	0.2	0.3
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.5	0.2	-1.2	-0.9	0.1	-0.3	-0.2	-1.0	0.7	-1.0	-0.8
Blood clot in the leg (DVT)	2.6	3.4	5.6	2.2	-1.7	-1.7	-2.1	-2.3	-1.2	-1.0	-0.4	-2.4	-2.3
Medication: Paracetamol	0.2	0.4	2.0	0.5	-1.4	-0.2	-0.4	-0.3	-0.5	0.5	-0.9	-0.3	-0.3
Headache pain in last month	1.0	1.6	5.1	1.6	-2.3	-0.5	-1.2	-1.1	-1.8	0.7	-0.6	-0.8	-1.2
Medication for cholesterol, blood pressure or diabetes	1.2	1.9	7.5	-1.7	0.4	-0.8	1.3	0.8	2.7	-1.6	1.8	0.3	0.5
Glaucoma (self-reported)	0.8	0.9	2.3	-0.2	1.5	1.4	0.4	0.9	0.1	1.0	-0.7	1.1	1.2
Gout (self-reported)	0.1	0.2	1.5	-0.4	-1.2	0.2	0.1	0.0	0.2	-0.1	0.3	-0.2	0.2
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.8	0.1	-0.1	0.6	-0.3	0.1	0.9	0.6	-0.4	0.6	0.5
Medication: Amlodipine	0.1	0.2	0.4	-0.3	0.6	0.0	0.6	0.5	-0.1	0.1	0.4	0.4	0.3
Medication: Ventolin 100micrograms inhaler	1.2	1.6	5.6	0.4	1.0	2.4	-0.7	0.4	-1.1	1.7	-1.5	1.1	0.8
Birth weight	2.1	4.6	16.1	-1.3	-2.9	-2.7	1.2	0.3	0.5	-3.2	4.0	-0.5	-1.0
Chronic bronchitis/emphysema (mother)	13.9	16.2	40.8	1.2	4.5	6.3	-0.7	1.8	-1.2	6.4	-5.2	4.0	3.6
High blood pressure (siblings)	0.1	0.1	0.3	-0.2	-0.5	-0.3	-0.1	-0.0	0.1	-0.4	0.2	-0.5	-0.3
Forced vital capacity (FVC), Best measure	3.5	12.9	29.8	0.1	-3.7	-5.5	-1.7	-3.4	-0.3	-5.0	3.2	-4.3	-4.1
Body fat percentage	0.6	2.4	15.1	0.8	-3.9	-1.4	-0.4	-0.9	-1.4	-0.5	0.3	-1.3	-1.3
Leg fat percentage (right)	0.5	1.9	9.2	1.3	-3.0	-0.4	-0.8	-0.9	-2.0	0.5	-0.5	-0.7	-1.0
Arm fat-free mass (right)	0.3	1.5	2.9	1.3	-1.5	-0.9	-1.3	-1.5	-1.5	-0.4	0.4	-0.9	-1.7
Exposure to tobacco smoke outside home	0.8	1.1	4.5	0.3	-2.1	-0.8	-0.5	-0.7	-1.2	-0.8	0.7	-0.7	-1.1
Comparative body size at age 10	1.1	2.9	8.6	1.2	0.4	2.5	-0.5	0.6	0.1	2.9	-2.5	1.8	1.5
Number of full brothers	1.5	1.9	5.3	1.0	1.0	2.0	-0.3	0.3	-1.4	2.3	-2.0	1.0	0.8
Worry too long after embarrassment	0.2	0.4	0.9	0.8	-0.8	-0.2	-0.9	-0.9	0.1	-0.1	-0.2	-0.6	-0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	3.0	1.7	-0.6	0.8	-1.0	-0.7	-1.1	1.3	-0.4	0.4	-0.6
Wheeze or whistling in the chest in last year	3.2	5.8	13.4	-0.4	1.6	3.7	1.1	2.2	-0.8	3.5	-2.6	2.7	2.9
Number of children fathered	0.7	0.8	1.6	-0.9	0.9	0.1	1.1	1.2	0.4	-0.2	1.3	1.0	0.8
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.1	3.6	-1.9	1.2	-0.7	1.6	0.8	0.1	-1.2	0.1	-0.2	1.0
Age at first live birth	0.6	1.1	5.2	-0.0	2.3	1.3	0.1	0.5	0.1	1.0	-0.6	1.0	1.3
Pulse wave peak to peak time	0.6	0.7	2.8	-1.2	1.7	-0.1	0.7	0.8	0.5	-0.4	0.4	0.5	0.9
Health satisfaction	1.4	1.8	5.6	1.2	0.8	2.0	-0.3	0.2	-0.9	2.4	-1.7	1.4	0.6
Shortness of breath walking on level ground	1.1	1.4	3.9	1.4	0.2	1.5	-1.2	-0.4	-0.7	2.0	-1.7	0.7	0.2
Qualifications: College or University degree	0.6	2.0	4.4	-1.5	2.1	0.0	1.6	1.2	1.7	-1.1	1.9	1.1	1.1
Eye problems/disorders: None of the above	1.8	2.1	5.9	-1.7	-0.7	-1.4	1.7	0.9	2.4	-1.8	1.7	-0.3	0.1
Mouth/teeth dental problems: Loose teeth	2.5	3.0	10.8	2.0	0.4	2.0	-1.3	-0.4	-0.6	2.9	-3.3	0.3	0.2
Emphysema/chronic bronchitis	5.9	6.6	18.5	1.6	2.8	3.5	-1.4	0.2	-1.3	4.3	-3.5	2.4	1.8
Medication for pain relief, constipation, heartburn	0.2	0.4	1.8	-0.1	1.3	0.9	-0.1	0.2	-0.3	0.5	0.1	0.7	0.4
Neck or shoulder pain in last month	1.7	2.5	7.0	1.1	-2.6	-1.4	-1.4	-2.0	-1.2	-0.7	-0.4	-1.8	-1.8
Medication: Blood pressure	2.0	3.5	12.4	2.7	-0.7	0.2	-2.2	-1.8	-3.5	1.4	-1.3	-0.8	-1.7
Angina (self-reported)	3.9	5.1	12.8	0.9	-3.3	-3.2	-0.8	-1.8	-0.2	-2.5	0.5	-3.6	-2.6
Migraine (self-reported)	0.7	0.9	2.3	1.5	1.4	0.6	-1.0	-0.4	-0.7	1.2	-0.3	0.8	-0.1
Medication: Ibuprofen	1.2	1.4	2.9	-1.1	-1.5	-1.3	1.0	0.1	1.5	-1.7	1.4	-0.6	-0.2
Medication: Allopurinol	0.5	0.6	2.5	0.7	-1.6	0.1	-1.2	-1.0	-0.5	0.2	-0.0	-0.4	-0.8
Medication: Omeprazole	0.2	0.3	1.1	0.8	0.2	0.4	-0.3	0.0	0.1	0.9	-1.1	-0.3	0.0
Medication: Seretide 50 evohaler	0.3	0.3	1.0	0.4	-0.9	0.1	-0.4	-0.5	-0.8	0.3	-1.0	-0.6	-0.1
Mean time to correctly identify matches	2.8	5.3	10.3	-2.7	1.8	1.7	2.8	3.2	2.4	0.2	1.0	2.4	3.0
Heart disease (mother)	3.6	4.4	11.8	-1.7	-2.1	-2.9	1.1	-0.1	1.5	-3.4	3.1	-1.6	-1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	3.0	-0.9	-0.6	1.3	1.0	1.7	0.4	0.6	0.7	1.7	1.4
Whole body fat mass	0.7	3.0	14.8	1.3	-3.8	-1.5	-1.0	-1.4	-1.6	-0.5	0.3	-1.5	-1.8
Leg fat mass (right)	0.6	2.5	11.5	1.5	-3.4	-0.7	-1.1	-1.3	-2.0	0.2	-0.3	-1.1	-1.5
Arm predicted mass (right)	0.2	1.2	2.4	1.2	-1.4	-0.8	-1.2	-1.3	-1.3	-0.4	0.6	-0.6	-1.5
Pulse rate, automated reading	0.4	1.4	3.1	-0.8	0.5	1.7	1.2	1.5	-0.2	1.2	-0.7	1.4	1.8
Alcohol intake frequency.	3.0	7.0	14.5	3.8	-1.3	1.7	-3.3	-1.7	-3.8	3.3	-3.1	0.1	-1.3
Comparative height size at age 10	0.1	0.3	0.9	0.6	-0.5	-0.3	-0.9	-0.8	-0.2	-0.2	0.2	-0.5	-0.7
Number of full sisters	0.9	1.0	2.7	-1.1	0.6	-0.8	1.3	0.6	1.7	-1.2	1.4	-0.2	0.1
Suffer from ‘nerves’	0.8	1.2	4.2	0.8	0.4	1.6	-0.1	0.4	-0.6	2.0	-1.7	0.9	0.7
Overall health rating	2.7	5.8	19.3	2.5	0.4	3.3	-1.5	-0.1	-1.3	4.4	-3.7	1.5	1.0
Chest pain or discomfort	0.2	0.2	1.8	0.0	-1.4	-0.2	0.2	-0.0	-0.4	-0.2	-0.1	-0.2	-0.2
Had major operations	0.2	0.2	1.0	0.8	-0.5	0.4	-1.0	-0.3	0.2	0.2	-0.4	-0.0	-0.3
Age at last live birth	0.3	0.5	1.0	0.6	1.0	0.3	-0.7	-0.8	-0.6	0.4	-1.0	-0.5	-0.0
Family relationship satisfaction	0.4	0.5	1.8	0.7	-0.7	0.3	-0.6	-0.7	-0.5	0.9	-1.3	-0.2	-0.2
Leg pain on walking	0.6	0.7	2.9	0.3	-1.7	-0.8	0.6	-0.2	1.2	-0.5	1.1	0.0	-0.6
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.3	5.1	-0.1	2.3	1.4	-0.3	0.4	-0.7	1.4	-1.2	0.8	1.1
Commuting to job workplace: Car/motor vehicle	0.5	0.6	1.7	-1.1	0.1	-0.5	1.1	0.9	0.6	-0.9	1.3	-0.0	0.2
Illness, injury, bereavement, stress in last 2 years	1.2	1.4	3.5	-1.3	1.1	1.3	1.4	1.6	-0.1	0.5	-0.1	1.2	1.9
Medication: Aspirin	1.3	1.7	3.4	1.6	-1.2	-1.0	-1.0	-1.3	-1.4	-0.2	-1.1	-1.8	-1.6
Supplements: Vitamin C	1.2	1.5	3.2	-0.1	-1.4	-1.7	-0.6	-1.2	0.0	-1.8	1.0	-1.4	-1.4
Knee pain experienced in last month	3.4	5.3	12.1	-0.2	-2.9	-3.5	-0.6	-1.6	0.6	-3.0	2.8	-2.5	-2.6
Hypertension (Self-reported)	0.3	0.8	2.8	0.7	0.8	1.3	-0.2	0.4	-0.7	1.7	-0.4	1.3	0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.1	3.3	1.4	-1.1	0.7	-0.8	-0.6	-1.8	1.1	-1.1	-0.0	-0.4
Illnesses of father: Heart disease	1.7	2.4	8.1	0.6	-0.5	-2.1	-0.4	-1.3	-0.1	-1.9	0.4	-2.9	-2.2
Illnesses of siblings: Diabetes	0.6	0.7	1.8	-0.4	0.7	0.8	1.3	1.1	0.6	0.6	-0.0	1.0	1.0
Smoking status: Previous	4.5	6.7	16.6	0.6	-3.0	-4.1	-1.3	-2.5	-1.5	-3.3	1.3	-3.3	-2.8
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.6	3.7	0.9	-1.0	-1.9	-1.2	-1.7	-0.0	-1.3	0.6	-1.4	-1.6
Whole body fat-free mass	0.4	2.2	4.2	2.0	-1.4	-0.7	-1.9	-2.0	-1.6	-0.0	0.0	-1.0	-2.0
Leg fat-free mass (right)	0.5	2.8	4.9	2.1	-2.0	-1.1	-2.0	-2.2	-1.7	-0.1	-0.1	-1.2	-2.2
Arm fat percentage (left)	0.4	1.5	9.3	0.8	-3.1	-0.7	-0.5	-0.8	-1.4	0.0	-0.2	-0.8	-0.9
Average weekly red wine intake	1.6	2.4	8.1	-1.8	-0.2	-1.9	1.2	0.3	1.5	-2.9	1.8	-1.4	-0.4
Handedness (chirality/laterality): Left-handed	2.2	2.7	5.2	2.1	-1.1	-0.8	-2.2	-2.3	-1.4	0.5	-1.3	-1.8	-1.9
Mood swings	0.2	0.4	1.1	-0.1	-0.1	1.0	0.3	0.5	1.1	0.8	-0.5	0.6	0.8
Loneliness, isolation	0.2	0.3	0.6	0.7	-0.6	0.4	-0.6	-0.6	0.7	0.7	-0.8	-0.0	-0.3
Long-standing illness, disability or infirmity	2.1	3.2	9.2	2.4	0.2	1.6	-1.8	-1.1	-1.4	2.8	-3.0	0.4	-0.0
Ever had bowel cancer screening	0.1	0.1	0.2	0.2	0.5	-0.4	0.3	0.2	-0.4	-0.4	0.4	0.3	0.1
Diabetes diagnosed by doctor	0.4	0.6	1.8	0.8	-0.2	0.8	-0.4	-0.2	-1.4	1.0	-1.1	0.3	-0.0
Ever had stillbirth, spontaneous miscarriage or termination	2.1	2.3	4.4	0.8	-2.1	-2.0	-0.6	-1.7	0.3	-1.4	0.6	-2.0	-2.1
Friendships satisfaction	0.2	0.2	0.6	-0.7	0.1	0.3	0.8	0.6	0.7	-0.2	0.2	0.2	0.4
Qualifications: nursing, teaching	1.6	2.4	5.3	-1.9	1.5	-0.3	2.2	1.3	1.3	-1.6	2.3	1.2	0.9
Commuting to job workplace: Walk	2.6	2.8	10.5	1.8	1.1	1.7	-1.4	-0.7	-0.9	2.7	-3.2	0.4	0.3
Eye problems/disorders: Cataract	0.2	0.2	0.8	-0.4	-0.7	-0.3	0.1	-0.1	-0.9	-0.5	0.3	-0.2	0.1
Mouth/teeth dental problems: Mouth ulcers	1.5	2.4	4.0	-0.8	1.4	2.0	1.1	1.6	1.5	1.6	-1.2	1.8	2.0
Medication for cholesterol	1.1	1.7	4.3	-0.0	-0.9	-1.7	-0.5	-1.3	-1.0	-1.6	0.6	-2.1	-1.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.7	2.0	6.0	-1.1	-1.0	-2.4	0.7	-0.7	0.9	-2.4	1.5	-1.2	-0.9
Back pain experienced in last month	3.9	5.7	9.7	2.8	-2.2	-2.0	-2.8	-3.0	-2.7	-0.4	-0.6	-2.4	-3.1
Mineral and other dietary supplements	0.7	0.9	2.9	0.6	0.2	1.3	-0.4	0.1	-1.1	1.6	-1.7	0.4	0.7
Breast cancer (self-reported)	1.2	1.4	3.3	-0.6	-1.5	-1.8	0.3	-0.6	0.1	-1.8	1.4	-1.3	-1.0
Asthma (self-reported)	0.6	1.1	3.2	-1.8	-0.9	0.2	1.7	1.3	0.4	-0.8	1.0	0.5	0.9
Osteoporosis (self-reported)	1.4	1.7	2.9	0.9	-1.5	-1.4	-1.3	-1.7	-1.0	-1.2	0.4	-1.5	-1.6
Osteoarthritis (self-reported)	1.6	2.1	4.8	1.7	-1.5	-0.6	-1.6	-1.6	-2.2	0.9	-1.4	-1.3	-1.3
Medication: Aspirin	0.9	1.2	2.4	1.3	-0.9	-0.9	-0.8	-1.1	-1.2	-0.2	-1.0	-1.6	-1.3
Medication: Gliclazide	0.1	0.1	0.5	0.3	-0.3	0.2	0.0	0.1	-0.7	0.1	0.1	0.5	0.2
Illnesses of father: None of the above (group 1)	0.7	0.8	2.3	1.0	-1.5	-0.6	-1.4	-0.9	-0.9	0.2	0.3	-0.1	-0.8
Smoking status: Current	2.2	3.4	7.0	2.6	-0.0	0.2	-2.4	-2.1	-2.5	1.4	-2.1	-1.3	-1.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	14.0	29.7	67.8	-0.6	-6.1	-8.2	-1.0	-4.0	0.1	-8.1	5.5	-6.5	-5.9
Whole body water mass	0.4	2.2	4.2	2.0	-1.5	-0.8	-1.9	-2.1	-1.6	-0.0	0.1	-0.9	-2.0
Leg predicted mass (right)	0.6	3.1	5.5	2.2	-2.0	-1.1	-2.1	-2.3	-1.8	-0.1	-0.1	-1.4	-2.3
Arm fat mass (left)	0.4	1.8	9.6	1.1	-3.1	-0.9	-0.8	-1.1	-1.5	-0.2	0.1	-0.9	-1.3
Number of self-reported non-cancer illnesses	1.2	2.1	4.2	2.0	-1.4	0.3	-1.9	-1.6	-1.8	1.4	-1.6	-0.4	-0.9
Average weekly champagne plus white wine intake	2.1	2.9	8.1	-1.3	-1.7	-2.4	0.8	-0.2	0.7	-2.8	2.5	-1.5	-0.8
Miserableness	2.0	3.5	6.8	-0.9	1.6	2.6	1.1	2.0	1.4	2.1	-1.0	2.5	2.4
Guilty feelings	0.2	0.4	0.8	0.1	0.2	-0.6	-0.4	-0.9	0.4	-0.6	0.3	-0.9	-0.8
Wears glasses or contact lenses	1.4	1.6	5.1	1.5	0.3	0.5	-1.8	-1.0	-2.2	0.9	-1.5	-0.6	-0.7
Ever taken oral contraceptive pill	1.2	1.4	2.9	0.3	-1.0	-1.7	-0.3	-0.9	-0.6	-1.6	1.5	-1.2	-1.5
Hearing aid user	1.0	1.1	2.5	-1.2	0.3	0.3	1.5	1.6	1.2	-0.2	0.7	1.1	1.2
Mother’s age at death	4.2	5.2	14.5	-1.3	-2.1	-3.8	0.5	-0.7	0.9	-3.8	3.0	-2.0	-1.7
Financial situation satisfaction	0.6	0.8	2.3	-1.1	-0.6	-0.9	0.9	0.2	0.4	-1.3	1.5	-0.2	-0.3
Tinnitus: Yes, now most or all of the time	0.3	0.3	1.1	0.4	-0.1	1.1	-0.2	0.4	-0.4	0.8	0.1	0.9	0.3
Commuting to job workplace: Public transport	2.1	2.6	4.5	-0.0	2.0	2.0	0.7	1.7	0.8	1.9	-1.3	2.0	2.1
Eye problems/disorders: Glaucoma	0.4	0.5	1.2	1.0	0.7	0.5	-0.7	-0.3	-1.1	0.7	-0.9	-0.1	-0.2
Medication: Blood pressure	2.1	4.0	8.6	-0.3	2.4	2.6	0.7	2.0	0.7	2.6	-1.0	2.9	2.5
Pain type(s) experienced in last month: Hip pain	1.9	2.4	4.8	1.7	-1.4	-1.7	-1.2	-1.8	-1.3	-0.6	-0.4	-2.2	-2.1
Supplements: Fish oil (including cod liver oil)	1.1	1.4	4.7	-1.5	0.2	-0.9	1.5	0.9	0.9	-1.6	2.2	0.1	0.2
High cholesterol (Self-reported)	0.2	0.3	0.8	-0.7	-0.4	-0.0	0.9	0.7	0.2	-0.1	-0.7	0.0	0.8
Medication: Bendroflumethiazide	1.7	2.6	4.8	-0.4	1.7	2.1	1.1	1.8	0.2	2.0	-1.0	2.2	1.9
Medication: Paracetamol	0.2	0.3	1.7	0.1	-1.3	-0.1	0.2	0.2	-0.1	0.4	-0.7	-0.1	-0.0
Medication: Lisinopril	0.4	0.6	2.1	0.8	-0.7	0.3	-1.4	-0.7	-0.8	1.0	-0.4	-0.3	-0.3
Medication: Atorvastatin	0.7	0.8	2.0	0.3	-0.3	-1.3	-0.0	-0.5	0.2	-1.3	0.9	-1.4	-1.1
Illnesses of father: High blood pressure	0.4	0.6	2.1	-1.1	-0.1	-0.4	0.6	0.1	1.0	-1.0	1.4	0.1	-0.1
Alcohol drinker status: Never	2.3	2.8	6.7	2.6	0.2	-0.2	-2.4	-2.0	-2.3	0.6	-1.3	-1.0	-1.7
Ever smoked	4.0	7.0	21.0	-0.5	-2.1	-4.6	-0.5	-2.1	-0.4	-4.0	2.4	-3.2	-2.7
Basal metabolic rate	0.5	2.6	4.5	2.0	-2.0	-1.0	-1.9	-2.1	-1.7	-0.1	0.1	-1.2	-2.1
Leg fat percentage (left)	0.4	1.4	8.4	0.9	-2.9	-0.5	-0.3	-0.5	-1.7	0.2	-0.3	-0.7	-0.8
Arm fat-free mass (left)	0.3	1.8	3.5	1.6	-1.8	-1.0	-1.4	-1.6	-1.3	-0.4	0.5	-0.9	-1.9
Number of operations (self-reported)	0.1	0.1	0.2	0.3	0.2	-0.4	-0.3	-0.5	-0.2	-0.4	0.4	-0.1	-0.5
Average weekly beer plus cider intake	0.4	0.6	1.5	-1.2	-0.4	0.1	1.2	0.5	0.0	-0.6	1.2	0.6	0.2
Irritability	0.9	1.6	4.2	-1.3	-1.1	-1.9	1.1	0.1	0.6	-2.1	1.5	-1.2	-0.5
Risk taking	4.2	6.2	17.7	-2.0	-1.6	-4.1	1.2	-0.8	1.3	-4.2	3.0	-2.4	-1.5
Ever had prostate specific antigen (PSA) test	0.3	0.4	1.1	1.1	0.2	0.0	-1.0	-0.7	-0.4	0.5	-0.3	-0.3	-0.6
Fractured/broken bones in last 5 years	1.0	1.4	3.2	0.5	-1.4	-1.8	-0.7	-1.2	-0.7	-1.2	0.8	-1.2	-1.5
Age started oral contraceptive pill	1.1	1.4	3.6	1.9	-0.3	0.3	-1.6	-1.0	-1.4	0.7	-1.5	-0.8	-0.9
Diastolic blood pressure, automated reading	0.2	0.7	1.8	0.5	-0.6	0.7	-1.4	-0.8	-0.8	1.2	-0.7	0.4	-0.5
Ever depressed for a whole week	0.6	0.7	1.8	-0.0	0.6	1.4	0.1	0.4	0.5	1.1	-0.7	1.1	1.1
Unable to work because of sickness or disability	3.9	5.0	10.2	3.0	0.0	1.5	-2.7	-1.7	-2.8	3.1	-3.2	-0.1	-0.9
Commuting to job workplace: Cycle	0.6	0.7	1.4	1.0	0.8	1.0	-0.8	-0.3	-0.7	1.0	-1.2	0.7	0.3
Myopia	2.3	3.3	7.4	0.8	-1.7	-2.5	-1.6	-2.1	-0.2	-1.8	0.7	-2.7	-2.1
Vascular/heart problems diagnosed by doctor	0.3	0.8	2.2	-1.5	0.3	-0.6	1.1	0.5	0.9	-1.4	1.0	-0.1	0.5
Cholesterol lowering medication	0.2	0.4	1.1	1.0	-1.0	-0.3	-0.6	-0.3	-0.7	0.1	-0.2	-0.3	-0.6
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.7	0.9	0.2	0.9	-0.4	0.2	-0.1	1.3	-1.2	0.2	0.3
Pain experienced in last month	5.6	9.3	15.7	-2.8	4.0	3.0	2.9	3.7	3.0	1.3	0.1	3.6	3.8
Supplements: Calcium	0.7	0.8	2.2	0.1	-1.0	-1.5	-0.2	-0.6	0.1	-1.4	0.9	-1.0	-0.9
Basal cell carcinoma (self-reported)	0.1	0.1	0.4	-0.5	-0.1	-0.1	0.0	0.1	0.2	-0.3	0.6	-0.3	-0.2
Heart attack/myocardial infarction (self-reported)	0.1	0.2	0.6	0.1	-0.1	0.6	0.3	0.2	0.4	0.3	-0.8	-0.1	0.4
Deep venous thrombosis (DVT) (self-reported)	2.2	2.8	4.7	2.1	-1.3	-1.5	-2.1	-2.1	-1.3	-0.8	-0.4	-2.0	-2.2
Heart disease (siblings)	0.5	0.6	1.5	1.1	-0.0	-0.5	-0.8	-0.9	-0.0	0.2	-1.2	-1.2	-0.8
Alcohol drinker status: Previous	0.3	0.3	1.1	0.8	-0.5	0.5	-0.4	-0.3	-0.6	0.4	-1.0	-0.3	-0.5
Pack years of smoking	79.4	116.5	292.4	2.7	10.5	16.9	-0.1	6.6	-1.2	17.1	-12.5	12.4	10.7
Impedance of whole body	0.3	1.6	4.5	-2.1	0.6	-0.2	1.5	1.5	1.8	-0.8	0.6	0.5	1.6
Leg fat mass (left)	0.5	1.8	10.2	1.1	-3.2	-0.7	-0.7	-0.9	-1.7	0.0	-0.1	-0.9	-1.2
Arm predicted mass (left)	0.4	2.1	3.6	1.9	-1.9	-0.8	-1.7	-1.8	-1.5	-0.1	0.1	-1.0	-1.9