Best TWAS P=1.77e-09 · Best GWAS P=3.99e-13 conditioned to 0.000726
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Hypothalamus | RP11-159N11.4 | 0.44 | 0.06 | lasso | 19 | 0.03 | 7.5e-02 | 4.3 | 5.2 | 2.0e-07 | -0.20 | 0.14 | 0.06 | TRUE |
| 2 | METSIM | Adipose | ANKK1 | 0.16 | 0.11 | enet | 13 | 0.16 | 9.8e-23 | -4.5 | -6.0 | 1.8e-09 | 0.24 | 1.00 | 0.00 | TRUE |
| 3 | YFS | Blood | ANKK1 | 0.04 | 0.03 | lasso | 3 | 0.03 | 2.9e-09 | -4.6 | -5.2 | 1.9e-07 | 0.19 | 1.00 | 0.00 | FALSE |
| 4 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | ANKK1 | 0.04 | 0.02 | blup | 66 | 0.03 | 5.0e-04 | 4.3 | 5.5 | 3.4e-08 | -0.22 | 0.21 | 0.21 | FALSE |
| 5 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ANKK1 | 0.04 | 0.03 | blup | 67 | 0.04 | 6.3e-05 | 4.1 | -5.1 | 3.0e-07 | 0.28 | 0.56 | 0.16 | FALSE |
| 6 | The Cancer Genome Atlas | Lung Adenocarcinoma | DRD2 | 0.06 | 0.07 | lasso | 2 | 0.07 | 6.6e-09 | -5.9 | 5.8 | 6.8e-09 | -0.75 | 0.12 | 0.88 | TRUE |
| 7 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | TTC12 | 0.07 | 0.06 | blup | 48 | 0.04 | 1.6e-02 | 5.1 | 5.5 | 4.8e-08 | -0.26 | 0.01 | 0.74 | FALSE |