Hub : Genes

ANKK1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.1565	0.0394	2.5e-11	0.109	0.097	0.157	0.145	0.156	6.1e-16	2.5e-14	9.8e-23	5.0e-21	1.3e-22
2	YFS	Blood	0.0382	0.0154	7.7e-05	0.027	0.010	0.025	0.025	0.027	2.4e-09	1.9e-04	7.8e-09	1.2e-08	2.9e-09
3	TCGA	Bladder Urothelial Carcinoma	0.0400	0.0250	3.8e-03	0.003	0.026	0.010	NA	0.006	1.6e-01	2.9e-03	4.7e-02	NA	1.0e-01
4	TCGA	Head and Neck Squamous Cell Carcinoma	0.0430	0.0290	8.1e-04	0.015	0.027	0.013	NA	0.018	7.2e-03	5.0e-04	1.3e-02	NA	4.0e-03
5	TCGA	Kidney Renal Clear Cell Carcinoma	0.0428	0.0240	1.8e-04	0.030	0.036	0.016	NA	0.028	2.1e-04	6.3e-05	6.3e-03	NA	3.4e-04
6	TCGA	Liver Hepatocellular Carcinoma	0.0800	0.0450	9.9e-04	0.023	0.040	0.022	NA	0.038	3.0e-02	5.6e-03	3.2e-02	NA	6.8e-03
7	TCGA	Thyroid Carcinoma	0.0920	0.0370	1.3e-06	0.064	0.074	0.066	NA	0.063	7.6e-07	9.9e-08	5.7e-07	NA	9.3e-07

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.6	1.0	3.5	-1.1	-0.1	1.9	0.9	-0.9	-0.7	0.0
Bipolar Disorder or Schizophrenia	1.8	4.4	11.4	-3.4	-2.2	2.8	1.3	-1.9	-0.7	-0.7
Depressed Affect (Nagel 2018)	14.5	30.4	45.0	-6.0	-5.1	1.2	6.7	-6.6	-5.8	-5.1
Depression (Nagel 2018)	9.6	14.5	23.6	-4.4	-3.5	2.0	4.9	-4.3	-4.1	-2.5
Intelligence (Savage-Jansen 2018)	1.6	5.0	10.0	1.4	0.4	-1.4	-3.2	2.6	3.1	2.1
Neuroticism (Nagel 2018)	18.6	43.8	67.1	-7.4	-5.9	3.2	8.2	-8.0	-6.9	-5.4
Schizophrenia (2018)	2.0	4.2	12.4	-3.5	-2.8	2.1	0.9	-1.7	-0.3	-1.0
Schizophrenia vs Biploar Disorder	0.2	0.3	0.8	0.2	0.3	-0.2	-0.8	0.3	0.9	0.4
Worry (Nagel 2018)	10.2	21.6	33.6	-5.8	-4.7	2.3	5.3	-5.3	-4.4	-3.6
Alzheimer’s Disease (in mother)	0.3	0.4	1.0	0.4	0.6	-1.0	-0.5	-0.0	0.7	-0.5
Alzheimer’s Disease (in father)	0.1	0.1	0.3	0.1	-0.3	0.0	-0.5	0.5	0.4	0.5
Alzheimer’s Disease (including proxy)	0.5	0.7	1.1	1.0	0.8	0.1	-1.0	0.9	0.9	0.8
Crohns Disease (2017)	0.6	1.3	4.5	1.6	2.1	-0.4	-0.4	0.3	1.2	0.5
Irritable Bowel Disease (IBD)	0.3	0.8	2.8	1.5	1.7	0.1	0.1	-0.1	0.5	0.4
Ulcerative Colitis (UC)	0.3	0.5	1.6	1.3	0.9	-0.2	-0.1	0.3	0.4	0.8
Major Depression (MDD)	6.2	7.5	11.1	-3.1	-2.4	1.9	3.1	-3.3	-2.7	-2.3
Reaction Time	0.2	0.4	1.7	0.3	-0.1	-1.3	0.5	0.1	0.0	0.6
Verbal and Numeric Reasoning (VNR)	1.8	4.3	7.3	1.1	0.4	-0.4	-2.7	2.7	2.7	2.7
Breast Cancer	0.3	0.7	2.4	1.2	1.5	-0.9	-0.4	0.4	0.0	0.1
Ovarian Cancer	3.3	4.4	6.6	2.2	1.7	-1.3	-2.0	2.5	2.1	2.6
Prostate Cancer	0.1	0.1	0.4	0.2	0.4	0.2	0.6	-0.3	-0.3	0.3
Age at First Birth	1.8	2.6	5.5	1.4	0.5	-1.4	-2.0	1.8	2.3	1.3
Bipolar Disorder (2011)	0.9	0.9	1.9	-0.8	-0.3	1.2	0.7	-1.2	-0.6	-1.4
Body Mass Index (BMI) (2010)	2.5	3.4	6.8	-1.2	-0.0	2.3	2.3	-2.0	-2.6	-1.0
Coronary Artery Disease (CAD)	2.6	3.2	5.9	-0.9	-0.0	1.1	2.4	-2.4	-2.2	-1.9
Crohns Disease (2012)	0.8	1.3	3.7	1.9	1.7	-0.1	-0.8	0.1	1.3	-0.2
Mean Putamen Volume	0.0	0.1	0.2	0.1	0.2	0.1	0.3	-0.4	0.1	-0.2
Fasting Glucose	1.2	1.4	3.5	-0.9	-0.2	1.2	1.5	-1.2	-1.9	-0.8
HbA1C	0.7	0.8	2.1	-1.4	-1.0	-0.1	0.4	-0.7	-0.5	-1.2
HDL Cholesterol	0.5	0.9	1.9	0.3	0.2	-0.4	1.1	-1.4	-0.9	-1.3
LDL Cholesterol	1.3	2.0	4.4	-1.4	-1.2	0.0	1.1	-1.6	-1.5	-2.1
Lupus	1.5	2.2	7.1	2.0	2.7	-1.5	-0.6	0.7	1.2	0.5
Neuroticism (2016)	8.2	11.9	15.9	-3.9	-3.1	3.2	4.0	-3.9	-3.5	-2.2
Primary Biliary Cirrhosis	0.2	0.3	0.9	0.4	0.4	1.0	-0.3	-0.3	0.4	-0.3
Rheumatoid Arthritis	0.2	0.3	1.0	0.4	1.0	0.5	0.5	-0.7	-0.5	-0.3
Schizophrenia (2014)	2.7	5.9	11.4	-3.4	-2.0	2.9	1.9	-2.8	-1.4	-2.1
Triglycerides	0.3	0.5	1.3	-1.1	-0.8	0.7	0.7	-0.2	-0.9	0.2
Type 2 Diabetes (T2D) (2012)	0.8	0.9	1.9	-1.4	-1.0	0.9	0.6	-0.7	-1.1	-0.7
Ulcerative Colitis	0.2	0.2	0.7	0.5	0.8	0.7	0.3	-0.3	-0.0	0.2
Blood Eosinophil Count	0.2	1.4	7.7	0.8	0.3	-2.8	-0.0	0.8	0.4	0.6
Blood Platelet Count	0.2	1.8	8.9	-0.3	-0.5	-3.0	1.1	-0.5	-0.9	-1.1
Blood Red Count	0.2	2.3	10.1	2.2	3.2	0.3	-0.3	0.8	-0.5	0.5
Blood White Count	1.0	7.4	14.1	-2.4	-1.0	3.1	3.8	-2.7	-3.5	-1.4
Heel T-Score	0.1	1.0	2.2	-0.1	-0.5	-1.1	-1.5	1.1	1.3	0.6
BMI	3.1	17.8	28.6	-4.7	-3.3	2.2	5.3	-4.6	-4.9	-3.7
Height	0.0	0.7	2.3	-0.0	0.2	-0.9	0.4	-0.8	-0.8	-1.5
Waist Hip Ratio (WHR)	2.4	10.6	17.7	-3.5	-2.2	2.0	4.2	-3.9	-3.6	-2.7
Systolic Blood Pressure	0.1	0.4	0.9	-0.4	-0.2	1.0	0.8	-0.3	-0.7	0.9
Smoking Status	0.4	0.9	2.4	-1.5	-1.1	1.3	0.5	-0.5	0.2	0.4
Allergy or Eczema	0.8	2.2	4.1	-1.1	-0.5	1.0	2.0	-1.8	-2.0	-1.2
Cardiovascular Disease	4.1	13.4	21.6	-3.8	-2.5	1.6	4.5	-4.7	-4.2	-3.3
Hypothyroidism (self reported)	0.1	0.2	0.7	0.6	0.8	0.0	-0.2	-0.2	0.2	0.0
Respiratory disease	1.7	3.8	7.5	-1.3	-0.6	2.2	2.7	-1.9	-2.7	-0.7
Type 2 Diabetes (T2D) (2018)	0.4	0.7	2.3	-0.2	-0.9	-1.5	-0.8	0.7	0.8	0.2
Lung FEV1/FVC ratio	0.2	0.9	2.1	0.3	1.0	0.4	1.3	-1.0	-1.4	-0.8
Lung FVC	0.7	3.4	7.5	1.2	0.3	-1.7	-2.6	1.8	2.7	1.5
Neuroticism	21.6	52.1	73.3	-8.6	-7.2	3.4	8.5	-8.5	-7.1	-5.8
Chronotype (morning person)	1.8	4.3	8.6	-1.7	-1.2	2.9	2.2	-2.2	-2.1	-1.5
Hair Pigment	0.0	0.9	2.0	-1.3	-1.2	0.4	0.4	-0.8	-0.4	-1.4
Tanning	0.0	0.1	0.3	0.0	-0.3	0.1	0.1	-0.6	0.1	-0.1
Hand grip strength (left)	0.2	0.4	1.2	0.9	1.1	-0.5	-0.5	0.6	0.0	-0.2
Number of treatments/medications taken	4.5	8.1	13.2	-2.5	-1.3	2.3	3.6	-3.6	-3.6	-2.1
Average weekly spirits intake	0.3	0.4	0.8	-0.3	-0.6	-0.0	-0.5	0.9	0.7	0.9
Sensitivity / hurt feelings	12.1	20.7	37.9	-4.9	-3.9	2.6	6.2	-5.2	-5.1	-2.7
Frequency of depressed mood in last 2 weeks	7.8	11.0	18.2	-4.3	-3.5	1.0	4.0	-3.9	-2.9	-2.4
Hearing difficulty/problems: Yes	1.0	1.5	2.3	-1.1	-1.1	0.8	1.5	-1.4	-1.5	-0.9
Relative age of first facial hair	0.8	1.7	3.7	-1.7	-1.5	1.9	1.2	-1.0	-0.8	-0.2
Other serious medical condition/disability diagnosed by doctor	8.3	10.8	19.1	-2.9	-1.4	2.4	4.4	-4.3	-3.7	-2.9
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.3	0.1	-0.3	0.5	-0.4	0.2	0.1	0.3
Ever had hysterectomy (womb removed)	2.1	2.4	4.7	-1.4	-0.8	-0.1	2.2	-2.2	-1.6	-1.5
Systolic blood pressure, automated reading	0.1	0.2	0.7	0.4	0.4	0.8	-0.1	0.0	0.2	0.6
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	3.0	0.8	1.7	0.7	0.7	-0.8	-1.2	-1.0
Angina	0.3	0.4	1.1	-0.5	-0.2	0.6	1.0	-0.7	-0.6	-0.3
Medication for hormone replacement therapy	0.3	0.4	1.2	0.0	-0.6	-0.7	-0.6	1.1	0.2	0.3
Vitamin and mineral supplements	0.3	0.4	1.3	0.5	1.1	-1.1	-0.1	0.0	-0.1	-0.6
Supplements: Zinc	1.6	1.7	3.1	1.7	1.3	0.0	-1.3	1.7	0.9	1.4
Medication: Co-codamol	0.5	0.6	1.1	-0.3	-0.0	0.9	1.0	-1.1	-0.9	-0.5
Medication: Metformin	1.0	1.5	3.4	-0.4	-0.7	-1.4	0.9	-1.4	-1.2	-1.8
Diabetes (father)	2.4	3.0	5.6	-2.4	-2.1	0.9	1.9	-1.4	-1.9	-0.9
Diabetes (mother)	2.2	2.8	4.4	-1.9	-1.3	0.3	1.8	-1.8	-1.7	-2.1
Severe depression (siblings)	0.7	0.8	1.8	-1.3	-1.3	0.8	0.7	-1.0	-0.1	-0.3
Pack years adult smoking proportion	3.4	5.2	10.8	-1.8	-0.8	1.2	3.3	-3.0	-2.7	-1.9
Impedance of leg (right)	0.1	0.4	1.0	0.2	0.8	-0.1	0.7	-1.0	-0.4	-0.6
Leg fat-free mass (left)	0.9	4.8	6.8	-2.4	-1.9	1.0	2.6	-2.3	-2.6	-2.0
Trunk fat percentage	3.9	15.5	23.4	-4.3	-3.1	2.4	4.8	-4.5	-4.4	-3.4
Hand grip strength (right)	0.2	0.5	1.8	1.1	1.4	-0.7	-0.2	0.5	-0.0	0.1
Townsend deprivation index at recruitment	0.8	1.1	2.7	0.8	0.6	-1.1	-1.0	1.0	1.6	0.8
Current tobacco smoking	3.0	4.9	10.0	-2.0	-0.8	1.5	3.2	-2.8	-2.8	-1.3
Average weekly fortified wine intake	0.6	0.8	2.2	0.2	0.4	0.2	0.8	-1.5	-0.5	-1.4
Maternal smoking around birth	1.9	2.7	6.8	-1.2	-0.6	1.6	2.6	-1.9	-2.1	-0.4
Fed-up feelings	5.5	10.0	20.0	-3.6	-2.5	1.2	4.5	-3.9	-3.3	-1.9
Frequency of unenthusiasm / disinterest in last 2 weeks	9.7	12.9	24.3	-4.0	-2.6	2.2	4.9	-4.2	-3.8	-2.6
Relative age voice broke	0.2	0.4	1.1	-0.2	-0.1	0.8	0.2	-0.8	-0.2	-1.1
Taking other prescription medications	4.1	6.3	10.2	-1.8	-1.0	2.2	3.1	-3.1	-3.2	-2.4
Age when periods started (menarche)	1.6	3.9	5.2	2.2	1.6	-2.2	-2.3	2.0	1.9	1.5
Bilateral oophorectomy (both ovaries removed)	1.4	1.6	3.1	-1.8	-1.5	0.9	0.9	-1.4	-0.7	-1.5
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.2	3.9	0.7	0.5	-2.0	-1.2	0.9	1.2	0.0
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	1.8	-0.4	-0.0	1.4	1.1	-0.8	-0.8	-0.6
Qualifications: CSEs or equivalent	0.8	1.1	3.3	-0.8	-0.5	-0.3	1.5	-1.0	-1.8	-0.4
Serious illness, injury or assault to yourself	0.2	0.2	0.5	-0.1	-0.0	0.2	0.5	-0.4	-0.7	0.6
High blood pressure	2.3	6.5	10.7	-2.4	-1.4	2.0	3.3	-3.0	-3.1	-2.1
Hayfever, allergic rhinitis or eczema	1.9	4.2	6.0	-2.3	-1.7	1.1	2.4	-2.3	-2.4	-1.7
Multivitamins +/- minerals	0.5	0.6	2.5	-1.0	-1.6	0.5	0.5	-0.5	-0.0	0.2
Stomach or abdominal pain in last month	0.5	0.6	1.5	1.2	1.1	-0.4	0.0	0.3	0.3	0.9
Supplements: Glucosamine	0.7	0.9	1.9	0.5	-0.6	0.3	-1.4	0.9	1.3	1.2
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.2	-0.5	0.3	-0.2	1.1	-0.8	-1.0	-0.3
Medication: Atenolol	0.2	0.2	1.1	0.2	1.0	-0.1	0.7	-0.2	0.1	0.1
Medication: Levothyroxine sodium	0.1	0.2	0.5	0.6	0.7	-0.5	-0.4	0.1	0.2	-0.3
Sitting height	0.6	4.2	7.4	-1.4	-0.7	0.1	2.7	-2.7	-2.6	-2.4
Chronic bronchitis/emphysema (father)	1.5	1.8	3.4	-1.5	-1.4	-0.6	1.1	-1.6	-0.8	-1.9
High blood pressure (mother)	0.4	0.5	1.7	0.0	0.2	-0.7	1.3	-0.6	-0.8	-0.6
Body mass index (BMI)	2.3	9.8	15.1	-3.9	-3.0	1.7	3.6	-3.1	-3.4	-2.6
Impedance of leg (left)	0.1	0.6	1.5	-0.1	0.6	0.3	1.1	-1.2	-0.9	-0.7
Leg predicted mass (left)	0.9	4.7	7.0	-2.3	-1.8	1.0	2.7	-2.3	-2.6	-2.0
Trunk fat mass	4.4	18.7	28.6	-4.7	-3.4	2.4	5.3	-4.8	-5.0	-3.8
Waist circumference	5.3	19.2	28.5	-4.9	-3.3	3.1	5.3	-4.6	-5.2	-3.6
Number of incorrect matches in round	0.7	1.2	2.0	-1.3	-1.4	0.4	1.4	-0.6	-1.4	0.7
Past tobacco smoking	0.7	1.4	3.4	0.0	0.5	-0.1	1.7	-1.3	-1.8	-1.2
Alcohol usually taken with meals	3.4	5.5	9.9	2.5	1.4	-2.0	-2.5	3.1	2.0	2.4
Nervous feelings	7.7	14.4	22.0	-4.5	-3.6	2.9	4.7	-4.2	-3.9	-2.3
Frequency of tenseness / restlessness in last 2 weeks	8.3	13.0	21.3	-4.0	-3.1	2.2	4.6	-4.3	-3.7	-2.6
Hearing difficulty/problems with background noise	6.2	10.0	17.1	-3.3	-2.3	2.4	4.1	-3.7	-3.6	-2.1
Hair/balding pattern: Pattern 2	1.1	1.4	4.2	-1.9	-2.1	0.6	-0.4	-0.3	0.3	-1.1
Had menopause	1.0	1.3	2.7	1.6	1.7	0.5	-1.3	0.4	1.2	0.4
Had other major operations	1.6	2.0	4.0	-0.8	0.2	-0.1	1.9	-1.9	-2.0	-1.4
Forced vital capacity (FVC)	0.1	0.3	0.8	0.1	-0.3	-0.9	-0.9	0.2	0.8	-0.0
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	2.4	0.3	-0.3	-1.5	-0.9	0.4	1.1	-0.2
Ever unenthusiastic/disinterested for a whole week	0.6	0.8	2.4	-1.4	-1.6	-0.5	0.5	-0.5	0.0	0.1
Qualifications: None of the above	0.2	0.4	1.7	0.4	1.3	0.8	0.7	-0.3	0.1	0.2
Financial difficulties in last 2 years	4.2	5.7	10.6	-2.6	-2.1	-0.0	3.3	-2.8	-2.7	-1.8
Mouth/teeth dental problems	0.6	0.9	2.3	0.6	-0.2	-0.5	-1.0	1.5	0.6	1.4
Heart attack	0.2	0.2	0.5	0.0	0.5	-0.7	0.5	-0.6	-0.0	-0.4
Allergy	2.2	5.1	9.2	2.4	1.8	-1.2	-2.9	2.4	3.0	1.6
Pain all over the body in last month	2.5	2.7	5.1	-1.4	-0.9	2.3	1.6	-1.8	-2.1	-0.7
Diabetes (self-reported)	0.1	0.2	1.0	-0.3	-0.6	-1.0	-0.2	0.3	0.0	0.3
Hayfever/allergic rhinitis (self-reported)	1.7	2.2	4.4	-1.5	-0.7	1.0	1.7	-2.1	-1.2	-1.7
Medication: Ramipril	0.6	0.8	2.9	-1.0	-0.2	-0.5	0.3	-1.2	-0.3	-1.7
Medication: Simvastatin	0.4	0.6	1.9	0.2	0.3	0.1	0.7	-1.4	-0.5	-1.3
Fluid intelligence score	1.3	2.7	4.4	-0.7	-1.1	-0.8	-2.1	2.0	2.1	1.9
Illnesses of siblings	0.7	1.0	1.5	1.2	0.8	-1.0	-1.2	0.9	1.1	0.3
Neuroticism score	18.3	38.2	60.7	-7.0	-5.6	2.9	7.8	-7.3	-6.5	-4.7
Weight	2.9	14.2	20.5	-4.1	-3.0	1.8	4.5	-4.1	-4.4	-3.6
Impedance of arm (right)	0.0	0.2	1.0	0.0	-0.3	1.0	-0.2	-0.4	0.5	0.0
Arm fat percentage (right)	4.2	16.7	24.3	-4.9	-3.6	3.2	4.7	-4.2	-4.3	-3.3
Trunk fat-free mass	0.9	5.0	7.6	-2.4	-1.7	0.6	2.8	-2.4	-2.7	-2.3
Hip circumference	3.0	12.9	19.9	-3.9	-2.6	2.4	4.4	-3.8	-4.5	-3.1
Time employed in main current job	3.2	3.7	6.2	2.1	1.4	-1.9	-1.7	2.5	1.9	2.0
Alcohol intake versus 10 years previously	0.3	0.4	1.2	-0.1	-0.3	0.6	-1.1	0.7	0.8	-0.1
Father’s age at death	0.7	0.9	2.2	1.5	0.7	-0.6	-1.0	0.7	1.3	0.6
Worrier / anxious feelings	3.7	7.0	10.6	-2.9	-2.5	2.1	3.2	-3.2	-2.6	-1.8
Frequency of tiredness / lethargy in last 2 weeks	7.4	12.1	16.8	-3.9	-3.2	2.9	4.1	-3.9	-3.9	-2.0
Falls in the last year	0.2	0.2	1.0	0.2	-0.0	-0.1	-1.0	0.7	0.4	0.4
Hair/balding pattern: Pattern 3	0.2	0.2	0.5	0.5	0.3	-0.4	-0.6	0.6	0.7	0.2
Number of live births	0.1	0.2	0.6	0.0	0.0	-0.1	0.7	-0.0	-0.4	0.8
Forced expiratory volume in 1-second (FEV1)	0.1	0.2	1.1	0.5	0.4	-1.0	-0.1	-0.2	0.1	-0.4
Pulse rate	0.2	0.4	1.5	0.9	1.2	-0.4	0.1	-0.2	0.2	-0.5
Happiness	3.7	4.4	7.8	-2.4	-1.8	0.1	2.4	-2.8	-2.0	-2.1
Noisy workplace	1.2	1.4	2.8	-0.3	0.7	1.6	1.7	-1.4	-1.3	-0.6
Qualifications: A levels/AS levels or equivalent	1.3	2.9	4.9	1.1	0.0	-2.1	-2.0	1.9	2.2	1.6
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.5	1.1	0.7	-1.2	-0.5	1.0	0.4	1.1
Mouth/teeth dental problems: Dentures	1.6	2.6	9.0	-0.3	1.1	-1.3	1.1	-2.2	-0.6	-3.0
Asthma	1.2	2.3	4.5	-1.1	-0.8	1.7	2.1	-1.5	-2.1	-0.5
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	1.3	0.8	1.1	-0.6	-0.1	0.0	-0.4	-0.5
Medication: Cholesterol lowering	0.2	0.4	0.9	-0.2	-0.1	-0.9	0.2	-0.8	-0.1	-0.9
Depression (self-reported)	3.3	3.9	6.1	-2.1	-1.3	1.1	2.4	-2.5	-2.1	-1.9
Medication: Lansoprazole	1.8	2.1	4.8	-1.7	-1.3	2.2	1.6	-0.6	-1.4	0.6
Prospective memory result	2.1	2.6	5.1	-0.7	-0.8	2.3	2.1	-1.8	-1.4	-1.5
Lung cancer (father)	0.4	0.5	1.4	-0.0	0.4	-1.2	0.9	-0.7	-0.7	-0.5
Illnesses of mother	0.9	1.1	4.0	-1.3	-1.1	2.0	0.1	-0.4	-0.9	-0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	1.0	0.9	0.8	-1.0	-0.3	-0.2	0.1	-0.6
Pulse wave Arterial Stiffness index	0.9	1.1	5.2	-0.7	0.3	2.3	0.9	-0.7	-0.9	-0.1
Impedance of arm (left)	0.1	0.4	1.0	0.9	0.4	0.4	-0.8	0.2	1.0	0.3
Arm fat mass (right)	4.4	18.1	25.3	-4.9	-3.6	2.7	5.0	-4.6	-4.7	-3.8
Trunk predicted mass	0.9	4.9	7.5	-2.4	-1.7	0.6	2.7	-2.4	-2.7	-2.2
Standing height	0.4	4.2	8.1	-0.9	-0.2	0.2	2.4	-2.8	-2.6	-2.9
Length of working week for main job	0.2	0.2	0.5	-0.3	-0.4	0.7	-0.5	0.5	0.1	0.3
Exposure to tobacco smoke at home	0.2	0.2	1.0	0.2	0.6	1.0	0.1	-0.1	0.5	0.2
Breastfed as a baby	0.1	0.1	0.3	0.2	0.3	0.2	-0.6	0.3	0.2	0.2
Tense / ‘highly strung’	8.6	14.3	25.7	-4.5	-3.6	2.1	5.1	-4.1	-4.2	-1.7
Seen doctor (GP) for nerves, anxiety, tension or depression	9.5	14.5	22.3	-4.7	-4.4	2.1	4.5	-4.2	-3.3	-2.5
Hair/balding pattern: Pattern 4	1.1	2.5	5.7	-0.3	0.1	-0.4	2.4	-2.1	-2.0	-1.9
Birth weight of first child	1.8	3.3	5.5	-2.2	-2.0	0.6	1.5	-2.1	-1.4	-2.3
Peak expiratory flow (PEF)	0.4	0.9	1.4	1.1	0.2	-0.3	-1.2	1.2	1.1	0.9
Pulse wave reflection index	0.7	0.9	2.4	-1.6	-0.9	1.0	0.8	-0.4	-1.0	-0.1
Ever highly irritable/argumentative for 2 days	2.7	3.2	5.3	-1.9	-2.3	-0.0	2.3	-1.8	-2.0	-0.9
Loud music exposure frequency	1.6	1.7	5.1	-1.7	-2.3	1.9	0.2	-0.3	-0.2	0.6
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	3.2	0.4	0.1	-1.8	-0.8	0.2	0.5	-0.1
Mouth/teeth dental problems: Bleeding gums	1.5	1.9	6.5	-1.0	-1.1	2.5	1.3	-1.0	-1.4	-0.2
Blood clot in the leg (DVT)	0.4	0.5	1.0	-0.8	-0.6	0.8	1.0	-0.6	-0.8	-0.2
Medication: Paracetamol	0.4	0.6	2.4	0.8	0.4	-0.3	-0.2	1.0	0.0	1.6
Headache pain in last month	0.7	1.3	2.9	1.2	0.7	-0.8	-0.8	1.5	0.8	1.7
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	1.1	0.8	0.2	1.0	-0.8	0.9	0.6	1.1
Glaucoma (self-reported)	2.1	2.4	5.1	1.2	0.3	-2.3	-2.2	1.4	1.9	0.3
Gout (self-reported)	1.3	1.8	3.3	-1.8	-1.8	1.4	1.1	-1.1	-1.3	-0.1
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.6	0.5	0.7	0.2	-0.2	-0.2	0.1	-0.3
Medication: Amlodipine	0.2	0.2	1.1	-0.5	-0.6	-1.0	0.1	-0.1	0.2	0.1
Medication: Ventolin 100micrograms inhaler	3.0	3.8	6.2	-2.3	-1.7	1.7	1.9	-1.8	-2.5	-1.5
Birth weight	2.1	4.5	7.0	-2.2	-1.4	1.8	2.4	-2.3	-2.6	-1.7
Chronic bronchitis/emphysema (mother)	2.3	2.7	4.2	-1.9	-1.2	-2.1	1.8	-1.8	-1.1	-1.6
High blood pressure (siblings)	0.8	1.2	2.4	-1.1	-0.4	0.7	1.5	-1.3	-1.5	-0.7
Forced vital capacity (FVC), Best measure	0.0	0.2	0.4	0.3	0.3	-0.4	-0.5	-0.3	0.3	-0.6
Body fat percentage	4.3	16.9	25.4	-4.6	-3.2	2.5	5.0	-4.6	-4.6	-3.6
Leg fat percentage (right)	4.2	15.3	22.8	-4.5	-3.2	2.0	4.8	-4.3	-4.5	-3.4
Arm fat-free mass (right)	1.0	5.1	9.3	-2.3	-1.4	0.2	2.9	-2.4	-3.0	-2.2
Exposure to tobacco smoke outside home	2.0	2.6	5.7	-1.6	-1.2	1.2	2.3	-1.3	-2.4	0.0
Comparative body size at age 10	2.3	6.5	9.5	-3.0	-2.4	3.1	2.1	-2.4	-2.5	-2.1
Number of full brothers	0.7	0.9	3.5	0.4	0.8	1.9	0.9	-0.2	-0.5	0.9
Worry too long after embarrassment	12.7	21.4	38.4	-4.5	-2.9	3.6	6.2	-5.7	-5.3	-3.1
Seen a psychiatrist for nerves, anxiety, tension or depression	2.9	3.8	8.1	-2.8	-2.4	1.3	1.8	-2.0	-1.8	-0.7
Wheeze or whistling in the chest in last year	5.6	9.9	17.2	-3.3	-2.1	2.1	3.8	-3.3	-4.1	-2.6
Number of children fathered	0.6	0.7	1.9	1.2	1.4	-0.2	-0.6	0.1	1.2	0.1
Reason for reducing amount of alcohol drunk: Health precaution	1.6	1.9	3.3	0.1	0.4	1.5	1.3	-1.8	-1.6	-1.7
Age at first live birth	1.2	2.1	5.0	1.2	0.1	-0.9	-2.2	2.0	1.7	0.9
Pulse wave peak to peak time	0.9	1.0	5.6	0.7	-0.2	-2.4	-0.7	0.5	0.6	-0.1
Health satisfaction	8.3	10.8	20.5	-2.8	-1.8	0.8	3.8	-4.5	-3.4	-4.1
Shortness of breath walking on level ground	2.0	2.4	4.3	-1.2	-1.3	-0.2	2.1	-1.8	-1.8	-1.7
Qualifications: College or University degree	1.1	3.4	8.0	1.2	0.0	-1.3	-2.8	2.2	2.2	1.7
Eye problems/disorders: None of the above	0.5	0.6	1.3	-0.6	-0.2	1.1	0.3	-1.1	-0.4	-0.8
Mouth/teeth dental problems: Loose teeth	0.7	0.9	3.3	-0.8	-0.7	1.8	0.7	-0.9	-0.6	-0.1
Emphysema/chronic bronchitis	2.9	3.3	7.9	-1.5	-0.6	0.1	2.8	-2.0	-2.7	-1.1
Medication for pain relief, constipation, heartburn	0.2	0.4	0.9	0.8	0.6	-0.4	-0.9	0.4	0.5	-0.5
Neck or shoulder pain in last month	1.4	1.9	8.2	1.2	1.3	0.1	-0.2	1.5	0.0	2.9
Medication: Blood pressure	0.4	0.8	1.4	-1.1	-0.6	-0.5	1.2	-0.7	-1.1	-0.6
Angina (self-reported)	0.2	0.2	0.6	-0.4	-0.3	0.4	0.8	-0.6	-0.4	-0.3
Migraine (self-reported)	0.4	0.5	2.5	0.2	0.1	-0.4	-0.1	-0.6	-0.3	-1.6
Medication: Ibuprofen	0.4	0.5	1.4	-0.1	0.5	-0.1	0.5	-0.7	-1.0	-1.2
Medication: Allopurinol	0.8	1.0	2.4	-1.5	-1.5	0.9	0.6	-0.8	-0.9	-0.3
Medication: Omeprazole	2.0	2.4	4.6	-2.1	-2.1	1.6	1.5	-1.3	-0.8	-0.5
Medication: Seretide 50 evohaler	2.2	2.5	6.0	-1.0	-0.3	1.2	2.4	-1.9	-2.1	-1.1
Mean time to correctly identify matches	0.2	0.4	1.9	0.4	-0.0	-1.4	0.0	0.3	0.5	0.7
Heart disease (mother)	1.2	1.4	2.7	-1.0	-0.9	1.4	1.6	-1.4	-1.1	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.1	1.0	0.3	0.3	-0.9	1.0	0.4	1.0
Whole body fat mass	4.7	19.5	29.1	-5.0	-3.5	2.5	5.4	-4.9	-5.0	-3.9
Leg fat mass (right)	4.6	18.0	28.3	-4.7	-3.3	2.3	5.3	-4.7	-4.9	-3.6
Arm predicted mass (right)	0.8	4.3	7.9	-2.1	-1.2	0.3	2.8	-2.2	-2.8	-1.9
Pulse rate, automated reading	0.6	1.9	3.9	2.0	1.6	-1.4	-1.1	1.2	1.2	0.7
Alcohol intake frequency.	2.8	6.5	11.3	2.0	1.2	-2.1	-3.4	3.2	3.3	1.8
Comparative height size at age 10	2.4	13.1	22.8	-2.9	-1.5	1.2	4.5	-4.5	-4.8	-4.0
Number of full sisters	0.4	0.4	1.3	0.7	0.9	-0.1	-0.3	0.5	0.5	1.1
Suffer from ‘nerves’	9.4	14.8	21.3	-4.1	-2.4	3.5	4.6	-4.6	-3.9	-3.4
Overall health rating	10.7	23.1	38.0	-4.6	-2.6	3.0	6.0	-6.2	-5.3	-4.7
Chest pain or discomfort	0.8	1.2	3.3	-0.4	-0.3	1.8	1.6	-1.3	-0.7	-0.1
Had major operations	2.8	3.2	8.0	-1.6	-1.1	2.8	1.6	-2.0	-1.4	-1.5
Age at last live birth	1.8	2.6	6.5	1.0	-0.2	0.2	-1.9	2.5	1.5	2.2
Family relationship satisfaction	2.0	2.5	4.4	-2.0	-1.6	0.5	1.5	-2.1	-1.3	-1.4
Leg pain on walking	2.5	3.1	4.2	-2.0	-2.0	-0.2	1.9	-2.1	-1.6	-1.9
Qualifications: NVQ or HND or HNC or equivalent	2.7	3.3	4.8	-2.1	-1.8	0.9	2.0	-1.5	-2.2	-1.9
Commuting to job workplace: Car/motor vehicle	2.0	2.3	5.9	1.1	0.9	-2.4	-1.5	1.5	1.9	0.6
Illness, injury, bereavement, stress in last 2 years	0.7	0.8	3.8	-0.1	0.6	0.8	0.2	-0.7	-0.5	-2.0
Medication: Aspirin	1.0	1.3	2.2	-1.4	-1.2	-1.5	1.0	-1.0	-0.6	-0.8
Supplements: Vitamin C	0.7	0.8	2.3	0.3	0.1	0.3	-0.9	1.5	0.2	1.5
Knee pain experienced in last month	1.3	2.0	3.7	-1.9	-1.5	-0.0	1.2	-1.5	-1.2	-1.7
Hypertension (Self-reported)	2.2	6.1	9.9	-2.3	-1.3	1.6	3.1	-3.0	-3.0	-2.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.2	2.8	-1.7	-1.4	1.1	1.1	-0.2	-0.9	0.9
Illnesses of father: Heart disease	1.6	2.2	4.0	-1.1	-0.6	1.3	1.8	-2.0	-1.8	-1.1
Illnesses of siblings: Diabetes	0.2	0.2	0.8	0.6	0.9	0.5	-0.2	0.2	-0.4	-0.1
Smoking status: Previous	1.9	2.8	6.0	1.2	0.5	-0.3	-2.4	2.0	2.5	1.5
Forced expiratory volume in 1-second (FEV1), predicted	1.5	3.0	6.3	-0.9	-0.2	-0.4	2.5	-2.1	-2.3	-2.0
Whole body fat-free mass	0.9	5.0	8.0	-2.4	-1.6	0.7	2.8	-2.4	-2.8	-2.2
Leg fat-free mass (right)	0.7	3.5	5.4	-2.1	-1.6	0.9	2.3	-1.9	-2.3	-1.6
Arm fat percentage (left)	3.6	14.2	21.2	-4.6	-3.5	2.7	4.3	-3.8	-4.0	-3.1
Average weekly red wine intake	3.0	4.4	7.2	1.5	1.0	-1.3	-2.4	2.6	2.7	2.5
Handedness (chirality/laterality): Left-handed	0.6	0.7	1.1	-0.9	-0.5	0.8	1.0	-0.7	-0.9	-0.8
Mood swings	12.7	23.0	36.2	-6.0	-5.2	2.7	5.5	-5.1	-4.8	-3.3
Loneliness, isolation	3.6	4.9	8.8	-2.3	-1.3	1.1	3.0	-2.7	-2.6	-1.8
Long-standing illness, disability or infirmity	7.4	11.3	18.1	-3.4	-2.1	1.9	4.1	-4.2	-3.7	-3.4
Ever had bowel cancer screening	1.7	2.0	5.7	-1.0	-0.5	2.4	1.5	-1.6	-1.3	-0.8
Diabetes diagnosed by doctor	0.1	0.2	0.5	-0.2	-0.4	-0.7	0.4	-0.2	-0.5	-0.2
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	5.2	1.6	1.2	-2.3	-0.4	0.7	-0.0	0.5
Friendships satisfaction	5.5	6.9	11.1	-2.6	-1.8	2.2	3.0	-3.3	-2.7	-2.4
Qualifications: nursing, teaching	0.8	1.2	4.5	0.8	0.1	-2.1	-1.2	1.1	0.6	0.4
Commuting to job workplace: Walk	1.0	1.1	2.0	-1.2	-1.0	0.2	1.1	-1.4	-0.7	-1.2
Eye problems/disorders: Cataract	0.4	0.5	1.2	-0.6	-0.9	-1.1	0.6	0.1	-0.6	-0.4
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	1.2	0.4	0.4	-0.2	-1.1	0.6	1.1	0.1
Medication for cholesterol	1.4	2.1	3.8	1.4	0.8	-1.0	-1.9	1.7	1.8	1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.5	4.1	6.2	-2.5	-2.4	2.3	2.1	-1.7	-1.9	-0.6
Back pain experienced in last month	0.7	1.1	2.7	0.3	0.8	1.6	1.1	-0.5	-1.6	0.1
Mineral and other dietary supplements	1.2	1.5	4.0	1.5	1.8	-2.0	-0.5	0.9	0.4	0.2
Breast cancer (self-reported)	0.6	0.7	3.4	1.0	1.8	-0.4	-0.0	0.1	0.1	0.6
Asthma (self-reported)	1.3	2.6	4.7	-1.3	-1.0	2.0	2.2	-1.6	-2.1	-0.5
Osteoporosis (self-reported)	0.3	0.4	0.6	0.8	0.7	-0.7	-0.6	0.3	0.8	-0.2
Osteoarthritis (self-reported)	2.9	3.7	6.4	-1.6	-1.0	1.7	2.0	-2.5	-2.2	-2.2
Medication: Aspirin	1.3	1.7	2.3	-1.5	-1.1	-1.3	1.4	-1.4	-1.1	-1.3
Medication: Gliclazide	0.1	0.1	0.4	0.2	-0.2	-0.7	-0.3	0.2	0.0	0.6
Illnesses of father: None of the above (group 1)	1.1	1.3	2.6	1.4	1.6	1.1	-1.3	1.0	0.6	0.8
Smoking status: Current	2.2	3.4	6.8	-2.0	-1.0	1.2	2.6	-2.2	-2.2	-0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.1	0.2	-0.3	-0.4	-0.4	-0.4	0.0	0.3	-0.4
Whole body water mass	0.9	5.1	8.1	-2.4	-1.7	0.6	2.8	-2.4	-2.8	-2.2
Leg predicted mass (right)	0.6	3.4	5.2	-2.0	-1.6	0.9	2.3	-1.9	-2.3	-1.6
Arm fat mass (left)	4.1	16.9	23.4	-4.8	-3.7	2.4	4.8	-4.3	-4.5	-3.6
Number of self-reported non-cancer illnesses	4.9	8.6	14.7	-2.6	-1.6	2.3	3.8	-3.6	-3.6	-2.2
Average weekly champagne plus white wine intake	0.8	1.1	2.0	-1.4	-1.2	-0.5	0.7	-1.1	-0.8	-1.3
Miserableness	12.4	21.4	30.5	-5.0	-4.8	1.7	5.5	-5.5	-4.6	-4.0
Guilty feelings	15.9	23.9	35.2	-5.9	-5.2	3.2	5.7	-5.3	-4.9	-3.2
Wears glasses or contact lenses	1.8	2.1	7.9	-0.5	-0.2	0.1	0.7	-2.1	-1.2	-2.8
Ever taken oral contraceptive pill	0.5	0.6	2.1	-0.9	-1.4	-1.0	0.2	-0.2	-0.4	-0.2
Hearing aid user	0.1	0.2	0.3	0.0	-0.0	0.5	-0.5	0.5	0.4	0.4
Mother’s age at death	2.6	3.3	7.0	1.0	0.2	-1.3	-2.3	2.2	2.6	1.9
Financial situation satisfaction	2.9	3.6	6.4	-1.7	-0.6	-1.0	2.4	-2.5	-1.8	-2.3
Tinnitus: Yes, now most or all of the time	0.7	0.8	1.6	-0.6	-0.3	1.3	1.0	-1.1	-0.9	-0.6
Commuting to job workplace: Public transport	2.2	2.6	5.1	-1.3	-0.2	0.5	1.6	-2.3	-2.1	-2.1
Eye problems/disorders: Glaucoma	1.5	1.8	5.7	0.8	0.3	-2.4	-1.6	1.1	1.6	0.3
Medication: Blood pressure	0.7	1.3	2.9	-0.8	-0.2	0.9	1.7	-1.7	-1.2	-0.8
Pain type(s) experienced in last month: Hip pain	1.3	1.6	4.0	-1.1	-0.9	0.5	1.1	-1.7	-1.1	-2.0
Supplements: Fish oil (including cod liver oil)	0.5	0.7	1.6	-1.0	-1.3	1.1	-0.3	-0.6	0.8	-0.0
High cholesterol (Self-reported)	1.2	2.1	4.3	-1.5	-1.1	0.5	1.8	-2.1	-1.1	-1.5
Medication: Bendroflumethiazide	1.6	2.4	3.9	-1.1	-0.3	2.0	1.9	-1.8	-2.0	-0.7
Medication: Paracetamol	0.2	0.3	1.4	-0.0	-0.2	-0.1	0.1	0.7	-0.2	1.2
Medication: Lisinopril	0.2	0.3	0.9	0.7	0.7	1.0	0.4	-0.2	-0.2	-0.1
Medication: Atorvastatin	0.6	0.8	2.0	-1.1	-0.5	0.6	1.4	-1.0	-0.6	0.1
Illnesses of father: High blood pressure	0.4	0.5	1.1	0.3	-0.2	-0.6	-0.7	0.8	1.0	0.7
Alcohol drinker status: Never	0.9	1.1	2.3	-0.4	-1.0	-1.2	-1.2	1.5	0.7	0.7
Ever smoked	0.4	0.7	1.8	0.1	-0.5	-0.1	-1.3	0.8	1.4	0.7
Basal metabolic rate	1.4	7.5	11.7	-3.0	-2.1	1.1	3.4	-3.0	-3.3	-2.6
Leg fat percentage (left)	4.4	15.9	24.4	-4.5	-3.2	2.2	4.9	-4.3	-4.7	-3.4
Arm fat-free mass (left)	1.7	8.7	14.2	-3.1	-2.1	1.3	3.8	-3.2	-3.6	-2.7
Number of operations (self-reported)	3.4	5.0	8.7	-2.0	-0.5	1.0	2.9	-3.0	-2.8	-2.2
Average weekly beer plus cider intake	1.1	1.6	2.9	-0.8	-0.3	1.7	1.6	-1.5	-1.2	-1.0
Irritability	7.0	11.8	17.1	-4.1	-3.7	0.0	4.1	-3.8	-3.7	-2.6
Risk taking	0.4	0.5	2.2	0.0	-0.3	-0.6	-0.6	0.9	0.0	1.5
Ever had prostate specific antigen (PSA) test	0.6	0.7	1.5	-0.8	-0.5	-1.2	0.7	-1.0	-0.3	-1.2
Fractured/broken bones in last 5 years	0.3	0.3	0.7	0.9	0.8	-0.2	-0.0	0.4	-0.6	0.6
Age started oral contraceptive pill	3.6	4.5	10.0	1.4	0.2	-2.7	-3.0	1.8	3.2	0.5
Diastolic blood pressure, automated reading	0.2	0.5	2.7	-0.2	0.3	1.6	0.6	-0.6	-0.4	-0.1
Ever depressed for a whole week	1.1	1.4	3.3	-1.4	-1.8	-0.5	1.4	-0.9	-1.1	-0.3
Unable to work because of sickness or disability	3.5	4.5	9.4	-1.5	-0.4	2.0	3.1	-3.1	-1.7	-1.8
Commuting to job workplace: Cycle	0.3	0.4	1.1	-0.8	-1.0	0.9	0.1	-0.2	-0.4	-0.4
Myopia	1.3	1.9	8.1	-1.9	-2.8	0.5	-0.9	0.3	0.5	-0.0
Vascular/heart problems diagnosed by doctor	2.2	6.0	9.3	2.4	1.4	-1.9	-3.0	3.0	2.8	2.1
Cholesterol lowering medication	1.3	2.0	4.6	-1.0	-0.8	1.2	2.1	-1.9	-1.4	-0.6
Medication: Omeprazole (e.g. Zanprol)	1.5	1.8	3.3	-1.8	-1.8	1.8	1.3	-1.0	-0.7	-0.1
Pain experienced in last month	0.3	0.5	1.6	-0.9	-0.4	-0.1	0.5	-0.9	-0.3	-1.2
Supplements: Calcium	0.3	0.3	1.0	0.0	-0.5	0.2	-1.0	0.7	0.6	0.5
Basal cell carcinoma (self-reported)	2.7	3.2	4.7	-1.8	-1.4	1.4	2.2	-1.8	-2.2	-1.5
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.5	-0.1	0.5	-0.6	0.7	-0.7	-0.3	-0.5
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	1.3	-1.1	-0.9	0.8	1.1	-0.6	-1.0	-0.2
Heart disease (siblings)	0.4	0.5	1.4	0.6	0.5	1.0	-0.2	0.6	0.6	1.2
Alcohol drinker status: Previous	1.0	1.1	2.1	-1.4	-1.4	1.4	0.6	-0.1	-0.2	1.0
Pack years of smoking	3.5	5.1	10.2	-1.7	-0.8	0.8	3.2	-3.1	-2.6	-2.2
Impedance of whole body	0.1	0.3	1.0	0.8	1.0	0.5	0.2	-0.6	0.0	-0.2
Leg fat mass (left)	4.6	17.9	28.3	-4.7	-3.3	2.4	5.3	-4.6	-5.0	-3.5
Arm predicted mass (left)	1.6	8.0	13.2	-3.0	-2.0	1.1	3.6	-3.1	-3.5	-2.6