Best TWAS P=2.83e-12 · Best GWAS P=1.14e-11 conditioned to 0.199
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Cerebellar Hemisphere | RP11-750H9.5 | 0.17 | 0.25 | lasso | 6 | 0.21 | 3.5e-06 | 6.4 | -6.4 | 1.2e-10 | -0.70 | 0.01 | 0.98 | FALSE |
| 2 | GTEx | Brain Cortex | C1QTNF4 | 0.26 | 0.04 | lasso | 8 | 0.02 | 1.2e-01 | 4.1 | 5.2 | 1.7e-07 | 0.56 | 0.05 | 0.10 | FALSE |
| 3 | GTEx | Esophagus Gastroesophageal Junction | NUP160 | 0.18 | 0.02 | enet | 18 | 0.11 | 7.1e-05 | 3.5 | -6.2 | 6.2e-10 | -0.60 | 0.03 | 0.88 | FALSE |
| 4 | GTEx | Esophagus Muscularis | MTCH2 | 0.09 | 0.04 | lasso | 6 | 0.02 | 1.8e-02 | -4.7 | -6.2 | 4.2e-10 | -0.57 | 0.18 | 0.67 | FALSE |
| 5 | GTEx | Liver | C1QTNF4 | 0.25 | 0.14 | enet | 16 | 0.20 | 2.3e-06 | -2.6 | 5.3 | 1.1e-07 | 0.58 | 0.12 | 0.80 | FALSE |
| 6 | GTEx | Pituitary | MADD | 0.42 | 0.32 | lasso | 6 | 0.39 | 8.9e-11 | 6.8 | -7.0 | 2.8e-12 | -0.89 | 0.01 | 0.98 | TRUE |
| 7 | METSIM | Adipose | NR1H3 | 0.03 | 0.03 | lasso | 6 | 0.04 | 4.7e-06 | 6.5 | -6.8 | 1.2e-11 | -0.85 | 0.04 | 0.94 | FALSE |
| 8 | The Cancer Genome Atlas | Colon Adenocarcinoma | PSMC3 | 0.09 | 0.05 | blup | 39 | 0.05 | 1.0e-03 | 6.4 | -5.9 | 3.3e-09 | -0.56 | 0.02 | 0.80 | FALSE |
| 9 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | FNBP4 | 0.10 | 0.03 | blup | 45 | 0.05 | 7.7e-06 | -4.6 | -5.2 | 1.8e-07 | -0.36 | 0.15 | 0.58 | FALSE |
| 10 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | PSMC3 | 0.05 | 0.01 | lasso | 3 | 0.02 | 9.4e-04 | 4.0 | -5.2 | 2.0e-07 | -0.31 | 0.03 | 0.08 | FALSE |
| 11 | The Cancer Genome Atlas | Prostate Adenocarcinoma | NUP160 | 0.03 | 0.02 | enet | 7 | 0.02 | 6.3e-03 | -4.8 | -5.5 | 3.7e-08 | -0.51 | 0.03 | 0.62 | FALSE |