[Hub]/) : Traits : Fed-up feelings :

chr2:23,453,834-25,141,538

Best TWAS P=3.19e-10 · Best GWAS P=2.17e-10 conditioned to 0.0301

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex UBXN2A 0.22 0.18 enet 28 0.24 3.0e-28 4.1 -5.2 2.4e-07 -0.90 0.02 0.98 FALSE
2 GTEx Brain Putamen basal ganglia PFN4 0.32 0.17 lasso 5 0.12 1.1e-03 5.2 5.2 2.5e-07 0.62 0.05 0.29 FALSE
3 GTEx Cells EBV-transformed lymphocytes PFN4 0.18 0.13 lasso 12 0.12 8.9e-05 5.2 5.5 3.3e-08 0.78 0.06 0.82 FALSE
4 GTEx Colon Transverse PFN4 0.14 0.07 lasso 2 0.04 3.3e-03 5.3 5.3 1.3e-07 0.65 0.10 0.13 FALSE
5 GTEx Esophagus Mucosa PFN4 0.16 0.15 lasso 4 0.15 3.6e-10 5.2 5.2 1.6e-07 0.71 0.50 0.50 FALSE
6 GTEx Heart Atrial Appendage UBXN2A 0.08 0.02 lasso 3 0.02 5.2e-02 5.8 6.0 2.7e-09 0.92 0.03 0.90 FALSE
7 GTEx Heart Left Ventricle PFN4 0.23 0.28 lasso 6 0.28 4.1e-15 5.3 5.3 9.8e-08 0.74 0.66 0.34 FALSE
8 GTEx Testis AC009228.1 0.27 0.34 lasso 5 0.38 5.4e-18 5.7 5.2 1.6e-07 0.53 0.22 0.78 FALSE
9 METSIM Adipose UBXN2A 0.07 0.03 bslmm 403 0.06 5.3e-10 3.9 5.4 5.3e-08 0.77 0.17 0.83 FALSE
10 ROSMAP Brain Pre-frontal Cortex PFN4 0.05 0.03 lasso 1 0.03 1.7e-04 5.2 5.2 2.2e-07 0.65 0.28 0.33 FALSE
11 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma PFN4 0.19 0.16 lasso 2 0.15 5.5e-08 5.2 5.2 2.1e-07 0.65 0.00 1.00 FALSE
12 The Cancer Genome Atlas Esophageal Carcinoma C2orf84 0.13 0.04 lasso 3 0.06 4.8e-03 4.5 5.5 4.3e-08 0.49 0.02 0.91 FALSE
13 The Cancer Genome Atlas Glioblastoma Multiforme C2orf84 0.13 0.07 blup 56 0.05 1.5e-02 4.4 6.2 7.4e-10 0.51 0.02 0.34 TRUE
14 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma PFN4 0.10 0.07 lasso 2 0.06 1.1e-07 5.2 5.2 2.1e-07 0.65 0.00 1.00 FALSE
15 The Cancer Genome Atlas Brain Lower Grade Glioma UBXN2A 0.04 0.04 lasso 1 0.03 1.4e-04 5.8 -5.8 4.9e-09 -0.93 0.02 0.96 FALSE
16 The Cancer Genome Atlas Lung Adenocarcinoma PFN4 0.15 0.09 lasso 3 0.09 7.3e-11 5.2 5.2 2.2e-07 0.65 0.00 1.00 FALSE
17 The Cancer Genome Atlas Lung Adenocarcinoma UBXN2A 0.05 0.00 blup 46 0.01 1.3e-02 -2.6 6.3 3.2e-10 0.68 0.01 0.39 TRUE
18 The Cancer Genome Atlas Pancreatic Adenocarcinoma PFN4 0.20 0.18 lasso 1 0.16 4.3e-07 5.3 5.3 1.1e-07 0.65 0.00 1.00 FALSE
19 The Cancer Genome Atlas Rectum Adenocarcinoma PFN4 0.38 0.11 lasso 5 0.05 2.8e-02 5.2 5.4 7.4e-08 0.65 0.00 0.78 FALSE