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chr2:23,453,834-25,141,538

Best TWAS P=3.19e-10 · Best GWAS P=2.17e-10 conditioned to 0.0301

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	UBXN2A	0.22	0.18	enet	28	0.24	3.0e-28	4.1	-5.2	2.4e-07	-0.90	0.02	0.98	FALSE
2	GTEx	Brain Putamen basal ganglia	PFN4	0.32	0.17	lasso	5	0.12	1.1e-03	5.2	5.2	2.5e-07	0.62	0.05	0.29	FALSE
3	GTEx	Cells EBV-transformed lymphocytes	PFN4	0.18	0.13	lasso	12	0.12	8.9e-05	5.2	5.5	3.3e-08	0.78	0.06	0.82	FALSE
4	GTEx	Colon Transverse	PFN4	0.14	0.07	lasso	2	0.04	3.3e-03	5.3	5.3	1.3e-07	0.65	0.10	0.13	FALSE
5	GTEx	Esophagus Mucosa	PFN4	0.16	0.15	lasso	4	0.15	3.6e-10	5.2	5.2	1.6e-07	0.71	0.50	0.50	FALSE
6	GTEx	Heart Atrial Appendage	UBXN2A	0.08	0.02	lasso	3	0.02	5.2e-02	5.8	6.0	2.7e-09	0.92	0.03	0.90	FALSE
7	GTEx	Heart Left Ventricle	PFN4	0.23	0.28	lasso	6	0.28	4.1e-15	5.3	5.3	9.8e-08	0.74	0.66	0.34	FALSE
8	GTEx	Testis	AC009228.1	0.27	0.34	lasso	5	0.38	5.4e-18	5.7	5.2	1.6e-07	0.53	0.22	0.78	FALSE
9	METSIM	Adipose	UBXN2A	0.07	0.03	bslmm	403	0.06	5.3e-10	3.9	5.4	5.3e-08	0.77	0.17	0.83	FALSE
10	ROSMAP	Brain Pre-frontal Cortex	PFN4	0.05	0.03	lasso	1	0.03	1.7e-04	5.2	5.2	2.2e-07	0.65	0.28	0.33	FALSE
11	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	PFN4	0.19	0.16	lasso	2	0.15	5.5e-08	5.2	5.2	2.1e-07	0.65	0.00	1.00	FALSE
12	The Cancer Genome Atlas	Esophageal Carcinoma	C2orf84	0.13	0.04	lasso	3	0.06	4.8e-03	4.5	5.5	4.3e-08	0.49	0.02	0.91	FALSE
13	The Cancer Genome Atlas	Glioblastoma Multiforme	C2orf84	0.13	0.07	blup	56	0.05	1.5e-02	4.4	6.2	7.4e-10	0.51	0.02	0.34	TRUE
14	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PFN4	0.10	0.07	lasso	2	0.06	1.1e-07	5.2	5.2	2.1e-07	0.65	0.00	1.00	FALSE
15	The Cancer Genome Atlas	Brain Lower Grade Glioma	UBXN2A	0.04	0.04	lasso	1	0.03	1.4e-04	5.8	-5.8	4.9e-09	-0.93	0.02	0.96	FALSE
16	The Cancer Genome Atlas	Lung Adenocarcinoma	PFN4	0.15	0.09	lasso	3	0.09	7.3e-11	5.2	5.2	2.2e-07	0.65	0.00	1.00	FALSE
17	The Cancer Genome Atlas	Lung Adenocarcinoma	UBXN2A	0.05	0.00	blup	46	0.01	1.3e-02	-2.6	6.3	3.2e-10	0.68	0.01	0.39	TRUE
18	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	PFN4	0.20	0.18	lasso	1	0.16	4.3e-07	5.3	5.3	1.1e-07	0.65	0.00	1.00	FALSE
19	The Cancer Genome Atlas	Rectum Adenocarcinoma	PFN4	0.38	0.11	lasso	5	0.05	2.8e-02	5.2	5.4	7.4e-08	0.65	0.00	0.78	FALSE