Best TWAS P=2.51e-10 · Best GWAS P=3.14e-11 conditioned to 0.0831
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | DLST | 0.09 | 0.11 | lasso | 2 | 0.11 | 4.0e-13 | -5.5 | 5.6 | 1.8e-08 | -0.66 | 0.76 | 0.24 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | YLPM1 | 0.10 | 0.03 | lasso | 6 | 0.02 | 7.9e-03 | -5.8 | 6.1 | 8.3e-10 | -0.77 | 0.09 | 0.40 | FALSE |
| 3 | GTEx | Muscle Skeletal | DLST | 0.28 | 0.26 | enet | 23 | 0.26 | 2.1e-25 | -6.5 | -6.3 | 2.5e-10 | 0.93 | 0.01 | 0.99 | TRUE |
| 4 | GTEx | Skin Not Sun Exposed Suprapubic | RPS6KL1 | 0.08 | 0.08 | enet | 11 | 0.07 | 1.5e-04 | 5.3 | 6.2 | 7.3e-10 | -0.72 | 0.27 | 0.69 | FALSE |
| 5 | GTEx | Stomach | RPS6KL1 | 0.09 | -0.01 | enet | 16 | 0.00 | 3.3e-01 | -3.9 | 5.6 | 2.5e-08 | -0.81 | 0.03 | 0.80 | FALSE |
| 6 | GTEx | Testis | AREL1 | 0.20 | 0.14 | enet | 34 | 0.13 | 2.1e-06 | 5.2 | 6.0 | 2.5e-09 | -0.57 | 0.88 | 0.12 | TRUE |
| 7 | METSIM | Adipose | ACYP1 | 0.03 | 0.02 | blup | 413 | 0.02 | 4.0e-04 | -3.2 | 5.2 | 1.8e-07 | -0.64 | 0.50 | 0.45 | FALSE |
| 8 | The Cancer Genome Atlas | Breast Invasive Carcinoma | RPS6KL1 | 0.03 | 0.02 | lasso | 3 | 0.02 | 8.5e-06 | 5.2 | 5.2 | 2.0e-07 | -0.58 | 0.89 | 0.10 | FALSE |
| 9 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | RPS6KL1 | 0.09 | 0.10 | blup | 49 | 0.11 | 5.1e-07 | -4.4 | 5.4 | 6.3e-08 | -0.77 | 0.62 | 0.35 | FALSE |
| 10 | The Cancer Genome Atlas | Lung Adenocarcinoma | RPS6KL1 | 0.03 | 0.01 | blup | 49 | 0.02 | 2.3e-03 | 3.9 | 5.3 | 1.4e-07 | -0.73 | 0.04 | 0.31 | FALSE |