Hub : Genes

ACYP1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Heart Left Ventricle	0.0651	0.0348	7.2e-03	0.085	NA	0.085	NA	0.079	2.9e-05	NA	2.9e-05	NA	5.5e-05
2	GTEx	Pancreas	0.2020	0.0750	8.0e-03	-0.006	NA	-0.002	NA	0.002	6.8e-01	NA	4.2e-01	NA	2.7e-01
3	GTEx	Spleen	0.2700	0.1270	9.4e-03	-0.005	NA	-0.003	NA	0.013	4.5e-01	NA	3.9e-01	NA	1.5e-01
4	GTEx	Whole Blood	0.1860	0.0530	3.9e-04	-0.003	NA	0.048	NA	0.016	8.0e-01	NA	3.1e-05	NA	1.1e-02
5	METSIM	Adipose	0.0292	0.0124	2.4e-04	0.017	0.020	0.002	0.019	-0.001	1.0e-03	0.0004	1.4e-01	0.00057	4.7e-01
6	TCGA	Brain Lower Grade Glioma	0.0981	0.0630	8.2e-05	0.034	0.024	0.025	NA	0.027	8.3e-05	0.0008	6.5e-04	NA	3.8e-04
7	TCGA	Lung Adenocarcinoma	0.0207	0.0178	4.0e-03	0.014	0.008	0.002	NA	-0.002	7.3e-03	0.0320	1.6e-01	NA	6.1e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.6	1.0	2.8	0.9	-0.8	-0.1	1.7	-0.9	1.1	0.9
Bipolar Disorder or Schizophrenia	0.9	2.3	5.0	2.2	-0.2	-0.4	1.9	-0.9	1.7	1.9
Depressed Affect (Nagel 2018)	3.1	6.5	16.7	-2.1	0.3	2.9	-0.1	4.1	-2.9	-2.6
Depression (Nagel 2018)	0.4	0.6	3.0	0.2	0.1	0.9	1.7	0.6	-0.5	-0.2
Intelligence (Savage-Jansen 2018)	0.6	1.8	3.7	1.3	-0.5	-1.1	0.3	-1.7	1.9	1.7
Neuroticism (Nagel 2018)	4.5	10.6	29.1	-3.0	-0.0	3.9	0.2	5.4	-3.2	-3.3
Schizophrenia (2018)	0.5	1.1	2.9	1.5	0.4	-0.4	0.8	-0.4	1.3	1.7
Schizophrenia vs Biploar Disorder	0.2	0.3	0.7	0.7	0.6	-0.8	0.3	0.4	-0.1	-0.1
Worry (Nagel 2018)	5.5	11.5	32.0	-3.2	-0.8	4.3	0.4	5.7	-3.0	-3.2
Alzheimer’s Disease (in mother)	0.2	0.2	0.7	0.4	0.1	-0.8	-0.0	-0.7	0.1	0.4
Alzheimer’s Disease (in father)	0.4	0.5	2.4	0.1	1.6	0.7	-0.5	0.2	-0.2	-0.2
Alzheimer’s Disease (including proxy)	0.5	0.7	1.5	1.0	1.2	-1.2	-0.3	-0.8	0.1	0.5
Crohns Disease (2017)	0.6	1.4	3.3	-0.3	-1.1	0.8	-1.8	1.8	-0.6	-0.9
Irritable Bowel Disease (IBD)	0.3	0.7	1.9	0.4	0.9	0.2	-1.4	0.3	1.0	1.1
Ulcerative Colitis (UC)	1.5	2.9	8.5	0.9	2.9	-0.5	-0.3	-0.9	2.0	2.3
Major Depression (MDD)	0.7	0.8	2.8	-0.5	-0.3	1.4	-0.4	1.7	-0.4	-0.3
Reaction Time	1.5	2.8	7.6	1.3	-0.1	0.5	-0.1	-2.1	2.8	2.4
Verbal and Numeric Reasoning (VNR)	0.7	1.7	3.5	0.4	-0.5	-1.7	-0.3	-1.8	1.9	1.3
Breast Cancer	0.6	1.4	3.9	-1.3	2.0	0.4	0.1	1.0	-1.1	-1.4
Ovarian Cancer	1.3	1.7	2.8	-0.5	-1.5	0.8	-1.6	1.7	-1.5	-1.2
Prostate Cancer	2.3	3.2	6.6	-1.6	0.0	1.9	-2.2	2.6	-1.6	-1.6
Age at First Birth	1.9	2.8	8.0	-1.6	-0.5	0.4	1.4	0.9	-2.5	-2.8
Bipolar Disorder (2011)	1.1	1.0	2.7	1.1	-0.4	-0.1	1.6	-0.9	0.9	1.2
Body Mass Index (BMI) (2010)	0.3	0.4	0.9	-0.7	-0.7	0.3	0.7	0.9	-0.4	-0.4
Coronary Artery Disease (CAD)	5.8	6.9	16.1	-2.2	2.2	1.9	-1.0	4.0	-2.8	-3.2
Crohns Disease (2012)	0.8	1.3	2.6	-1.6	-1.3	0.3	-0.7	1.4	-0.9	-1.2
Mean Putamen Volume	0.5	0.6	2.2	1.5	1.1	-0.3	0.5	-0.3	-0.0	0.5
Fasting Glucose	0.2	0.2	0.6	0.5	0.1	-0.2	-0.8	-0.4	0.3	0.5
HbA1C	0.4	0.4	1.0	0.4	-0.7	0.0	1.0	-0.4	0.8	0.5
HDL Cholesterol	0.3	0.5	0.8	-0.4	-0.8	-0.7	0.9	-0.9	0.3	0.1
LDL Cholesterol	0.6	1.0	2.2	0.1	1.3	-1.1	0.3	-1.5	1.1	0.6
Lupus	1.0	1.4	3.3	-0.5	-0.7	0.3	0.4	1.7	-1.8	-1.8
Neuroticism (2016)	1.0	1.5	5.8	-1.4	-0.4	0.9	-0.8	2.4	-0.7	-0.9
Primary Biliary Cirrhosis	0.9	1.2	3.8	-1.9	-0.1	0.1	-0.1	1.1	-1.1	-1.5
Rheumatoid Arthritis	3.9	5.4	10.4	3.2	-0.1	-2.2	-0.1	-2.3	2.9	3.0
Schizophrenia (2014)	0.1	0.2	0.7	0.2	-0.2	0.2	0.3	0.8	0.4	0.5
Triglycerides	1.4	2.3	5.2	-0.5	2.1	1.5	0.3	2.3	-1.4	-1.5
Type 2 Diabetes (T2D) (2012)	1.2	1.3	3.2	1.5	0.4	-0.2	0.3	-1.0	1.8	1.6
Ulcerative Colitis	0.5	0.7	4.3	0.0	2.1	0.4	0.7	-0.1	0.1	0.4
Blood Eosinophil Count	1.4	10.5	62.1	0.9	0.9	0.2	7.9	-2.9	0.8	1.0
Blood Platelet Count	1.2	13.9	36.0	3.4	-0.3	-3.8	0.8	-6.0	4.1	4.2
Blood Red Count	0.3	3.2	5.7	1.6	0.9	-1.6	1.8	-1.6	2.2	2.4
Blood White Count	0.3	2.5	7.2	1.3	-0.0	-1.1	1.6	-2.7	1.5	1.7
Heel T-Score	4.9	39.3	72.9	-7.4	0.1	5.8	0.1	7.0	-8.1	-8.5
BMI	0.2	1.0	3.1	0.5	1.1	0.1	0.9	-0.5	1.2	1.7
Height	1.6	31.1	88.4	5.3	0.7	-9.4	1.5	-6.1	6.0	5.0
Waist Hip Ratio (WHR)	0.3	1.4	3.1	0.3	0.5	1.5	-1.8	0.2	1.4	1.3
Systolic Blood Pressure	5.7	28.3	45.9	-5.7	1.3	6.8	-3.2	6.4	-5.9	-5.7
Smoking Status	0.4	0.9	3.2	-1.2	-0.2	0.2	-1.8	0.8	0.7	0.4
Allergy or Eczema	0.5	1.4	2.7	0.8	-1.5	-0.2	1.6	-1.0	1.2	1.3
Cardiovascular Disease	1.2	3.9	6.6	-2.6	0.3	1.9	-1.0	2.5	-2.3	-2.1
Hypothyroidism (self reported)	3.9	9.0	15.9	-2.9	1.2	3.2	0.1	4.0	-3.6	-3.7
Respiratory disease	0.2	0.5	1.6	0.2	0.7	1.3	0.6	0.7	0.5	0.4
Type 2 Diabetes (T2D) (2018)	0.3	0.6	1.8	-1.1	1.1	0.3	-1.3	0.2	-0.0	-0.2
Lung FEV1/FVC ratio	0.6	2.9	11.9	0.8	-2.0	-1.2	1.4	-3.5	0.3	0.1
Lung FVC	0.7	3.8	9.0	3.0	-0.6	0.3	1.9	-0.6	2.2	2.8
Neuroticism	4.3	10.5	29.1	-3.4	0.7	4.3	0.2	5.4	-2.5	-2.7
Chronotype (morning person)	0.3	0.8	1.7	0.4	-1.2	-1.3	1.2	-0.3	-0.6	-0.7
Hair Pigment	0.1	1.7	3.8	-0.8	0.8	1.0	-1.9	1.5	-1.4	-1.3
Tanning	0.3	3.1	7.7	2.8	-1.8	-1.7	-0.3	-2.4	0.7	1.3
Hand grip strength (left)	2.1	5.4	11.3	-2.3	2.5	2.6	0.9	3.4	-1.8	-2.1
Number of treatments/medications taken	3.6	6.4	17.6	-2.1	0.6	3.2	-1.0	4.2	-2.3	-2.4
Average weekly spirits intake	4.0	5.0	9.2	2.2	-1.1	-2.2	-0.6	-2.6	2.8	3.0
Sensitivity / hurt feelings	1.1	1.8	5.2	-1.6	0.1	1.3	-0.2	2.3	-1.3	-1.2
Frequency of depressed mood in last 2 weeks	0.6	0.9	1.8	-1.1	0.5	1.1	0.8	1.3	-0.7	-0.8
Hearing difficulty/problems: Yes	3.5	5.4	11.0	2.8	1.0	-1.6	0.2	-2.2	3.1	3.3
Relative age of first facial hair	0.7	1.5	4.9	1.1	0.1	-2.2	-0.2	-1.5	1.1	0.8
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.0	0.9	0.5	0.7	0.4	1.0	-0.0	0.0
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.0	0.6	-0.3	-0.4	-1.0	1.0	-0.1	-0.2
Ever had hysterectomy (womb removed)	0.6	0.7	2.5	0.9	-1.6	-1.1	-0.2	-0.3	0.4	0.3
Systolic blood pressure, automated reading	3.6	10.5	16.5	-3.8	1.3	4.1	-2.5	3.9	-3.1	-3.2
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	3.3	-0.7	-1.8	-0.1	0.0	0.7	-0.2	-0.6
Angina	2.8	3.6	6.1	-2.0	1.0	1.5	-1.2	2.5	-2.2	-2.4
Medication for hormone replacement therapy	0.6	0.7	1.2	-0.8	-0.3	1.0	1.1	1.1	-0.5	-0.8
Vitamin and mineral supplements	0.3	0.4	0.6	-0.7	0.8	-0.2	0.7	0.4	-0.7	-0.6
Supplements: Zinc	0.4	0.4	0.9	-0.3	0.8	-0.4	-0.4	-0.7	1.0	0.8
Medication: Co-codamol	0.6	0.7	2.2	-0.2	-0.2	0.9	0.2	1.5	-0.9	-0.9
Medication: Metformin	0.2	0.3	0.5	-0.7	-0.4	0.6	-0.1	0.7	-0.7	-0.7
Diabetes (father)	0.3	0.4	0.9	0.2	-0.6	0.4	0.4	0.0	1.0	0.9
Diabetes (mother)	0.3	0.4	1.6	0.4	0.9	-1.3	-0.2	-0.4	0.3	0.3
Severe depression (siblings)	2.0	2.3	4.0	-1.2	-1.5	2.0	0.7	2.0	-1.4	-1.5
Pack years adult smoking proportion	0.2	0.4	1.2	0.1	1.1	-0.7	-0.1	-0.7	0.5	0.4
Impedance of leg (right)	2.1	10.1	17.2	-3.4	0.2	3.3	-1.4	4.1	-3.5	-4.1
Leg fat-free mass (left)	1.9	9.9	16.6	2.9	1.7	-4.1	1.7	-3.5	3.5	3.8
Trunk fat percentage	0.2	0.9	2.8	1.1	1.7	0.6	0.7	0.6	0.7	0.7
Hand grip strength (right)	1.2	3.3	5.9	-2.0	1.9	2.4	0.3	2.0	-1.6	-1.8
Townsend deprivation index at recruitment	0.5	0.7	2.4	-1.6	-1.4	0.5	0.1	0.5	-0.2	-0.4
Current tobacco smoking	0.1	0.2	0.5	-0.3	0.3	0.6	-0.5	0.1	0.5	0.7
Average weekly fortified wine intake	2.1	2.5	8.3	-1.4	-2.9	1.5	-0.3	1.1	-1.4	-1.2
Maternal smoking around birth	0.3	0.4	2.6	-0.1	-0.1	0.1	1.6	-0.0	-0.1	0.0
Fed-up feelings	5.9	10.7	27.2	-3.4	1.8	3.0	-0.7	5.2	-3.4	-3.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.0	3.5	-0.1	0.6	1.4	1.9	0.8	-0.6	-0.4
Relative age voice broke	0.5	0.7	3.0	0.9	-0.2	-0.9	1.7	-0.3	0.3	0.5
Taking other prescription medications	2.9	4.4	13.5	-1.9	1.3	1.9	0.9	3.7	-1.8	-2.1
Age when periods started (menarche)	0.5	1.2	2.8	-1.2	1.7	0.4	-0.4	1.1	-1.0	-1.3
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	2.5	0.7	0.4	-0.6	-1.6	0.4	0.3	0.4
Heel bone mineral density (BMD) T-score, automated (left)	3.6	8.1	14.3	-3.8	1.4	1.9	1.0	2.9	-3.6	-3.8
Tinnitus: Yes, but not now, but have in the past	0.7	0.8	1.8	-1.4	-1.3	0.6	-1.2	0.1	-0.3	-0.1
Qualifications: CSEs or equivalent	0.2	0.3	1.5	0.4	1.2	0.2	0.2	0.4	0.1	0.6
Serious illness, injury or assault to yourself	0.8	1.0	2.2	1.5	-0.9	-1.0	-0.5	-0.7	1.0	1.1
High blood pressure	0.4	1.2	5.5	-0.7	0.2	0.7	-2.3	1.2	-0.4	-0.1
Hayfever, allergic rhinitis or eczema	0.8	1.8	3.1	1.6	-0.8	-0.6	1.0	-1.2	1.7	1.8
Multivitamins +/- minerals	0.3	0.4	2.3	-0.0	-1.5	0.4	-0.1	0.6	-0.1	-0.1
Stomach or abdominal pain in last month	0.2	0.2	0.7	-0.0	-0.4	-0.4	0.9	0.5	0.0	0.0
Supplements: Glucosamine	0.8	1.0	3.5	0.2	-1.9	-0.3	-1.5	-0.2	-0.8	-0.6
Diverticular disease/diverticulitis (self-reported)	2.1	2.5	4.7	1.2	-0.4	-2.0	-0.4	-2.2	1.9	1.8
Medication: Atenolol	2.9	3.7	7.4	-1.8	-1.0	1.6	-1.8	2.7	-2.1	-1.9
Medication: Levothyroxine sodium	4.0	6.8	12.7	-3.4	0.0	2.3	-1.6	3.6	-2.7	-2.8
Sitting height	0.1	0.9	3.0	-1.7	0.6	-0.5	-1.0	0.7	-0.3	-0.9
Chronic bronchitis/emphysema (father)	0.3	0.4	1.4	0.5	0.5	-1.2	-0.5	-0.8	-0.1	-0.0
High blood pressure (mother)	0.1	0.2	0.8	0.1	-0.2	0.6	-0.9	0.2	-0.3	0.1
Body mass index (BMI)	0.3	1.1	2.2	1.1	1.5	-0.3	1.2	-0.1	1.0	1.3
Impedance of leg (left)	2.3	11.1	18.7	-3.2	-0.2	3.8	-2.0	4.2	-3.6	-4.3
Leg predicted mass (left)	1.9	9.9	16.5	3.0	1.6	-4.1	1.8	-3.5	3.5	3.7
Trunk fat mass	0.5	2.1	3.5	1.9	1.7	-1.0	1.0	-0.5	1.7	1.7
Waist circumference	0.9	3.3	6.0	2.2	1.8	-1.3	0.5	-1.2	2.4	2.5
Number of incorrect matches in round	0.6	1.0	3.0	-1.7	0.1	0.8	-1.2	1.1	-0.4	-0.7
Past tobacco smoking	0.6	1.1	2.7	0.2	1.2	-1.5	-0.1	-1.6	0.5	0.9
Alcohol usually taken with meals	1.7	2.7	5.8	1.5	0.6	-0.8	-0.6	-2.0	2.3	2.4
Nervous feelings	5.4	10.1	23.8	-3.1	0.8	4.2	-2.1	4.9	-2.7	-2.7
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	2.2	-0.8	-1.3	1.5	-0.8	1.2	0.0	-0.2
Hearing difficulty/problems with background noise	1.1	1.8	4.5	1.2	-0.8	-0.8	0.3	-1.1	2.1	2.1
Hair/balding pattern: Pattern 2	0.3	0.4	1.2	-1.1	0.9	0.1	0.5	0.4	0.3	-0.0
Had menopause	0.1	0.2	0.5	0.4	-0.2	-0.7	-0.5	0.1	0.4	0.3
Had other major operations	1.3	1.6	2.7	1.6	-1.4	-1.4	0.2	-0.6	1.2	1.6
Forced vital capacity (FVC)	1.1	4.3	7.5	2.6	-0.1	-2.1	0.8	-2.0	2.6	2.7
Heel bone mineral density (BMD) T-score, automated (right)	3.3	7.5	13.5	-3.7	1.5	2.1	0.8	2.9	-3.3	-3.5
Ever unenthusiastic/disinterested for a whole week	3.4	4.1	7.2	-2.0	-1.3	2.0	1.9	2.7	-2.0	-2.1
Qualifications: None of the above	0.1	0.2	0.6	0.5	0.1	-0.4	-0.8	0.6	-0.4	-0.4
Financial difficulties in last 2 years	1.2	1.6	3.2	1.1	-0.3	-1.4	0.8	-1.4	1.8	1.5
Mouth/teeth dental problems	0.4	0.6	2.2	-0.7	1.5	0.9	0.2	-0.2	-0.4	-0.7
Heart attack	1.4	1.8	3.5	-1.9	0.8	1.2	0.1	1.3	-1.5	-1.8
Allergy	1.1	2.5	5.4	-1.5	-0.1	0.6	-1.7	1.2	-2.3	-2.3
Pain all over the body in last month	0.9	0.9	2.0	1.4	0.1	-0.4	1.4	-0.8	0.8	1.0
Diabetes (self-reported)	0.4	0.6	1.2	-0.5	0.2	0.1	-1.1	0.9	-0.9	-1.0
Hayfever/allergic rhinitis (self-reported)	1.1	1.5	7.7	0.8	0.8	0.3	2.8	-0.5	0.5	0.9
Medication: Ramipril	1.4	1.8	5.1	-1.3	0.1	2.3	-0.3	1.6	-1.2	-1.1
Medication: Simvastatin	0.9	1.3	4.0	-1.0	-0.1	0.0	-0.8	2.0	-1.1	-1.6
Fluid intelligence score	0.1	0.2	0.4	-0.5	0.5	0.2	-0.6	-0.1	0.5	0.1
Illnesses of siblings	0.3	0.4	1.4	0.4	-0.0	-0.3	1.2	-0.8	0.4	0.4
Neuroticism score	4.1	8.5	25.4	-3.1	1.1	3.6	-0.5	5.0	-2.1	-2.3
Weight	1.1	5.2	8.1	2.3	2.0	-2.9	1.2	-1.9	2.6	2.7
Impedance of arm (right)	0.1	0.4	1.6	0.9	-0.0	0.7	1.3	-0.1	0.2	0.3
Arm fat percentage (right)	0.6	2.4	5.3	1.8	1.1	-0.1	2.3	-0.5	1.7	2.0
Trunk fat-free mass	1.6	9.4	26.1	2.5	1.2	-5.1	0.8	-3.4	3.2	3.1
Hip circumference	1.4	6.0	9.2	2.6	2.3	-3.0	1.1	-2.2	2.6	2.7
Time employed in main current job	0.7	0.8	1.3	-0.5	1.0	0.8	0.7	1.0	-0.8	-1.1
Alcohol intake versus 10 years previously	1.7	2.5	5.2	2.3	-0.4	-1.9	-0.5	-1.3	1.8	1.8
Father’s age at death	2.2	3.0	5.8	1.6	0.7	-1.8	1.7	-2.4	1.8	1.6
Worrier / anxious feelings	2.7	5.1	15.5	-2.3	0.5	3.0	0.7	3.9	-1.6	-1.6
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	1.5	1.2	0.3	-0.5	-0.1	0.1	1.1	1.1
Falls in the last year	1.9	2.5	4.7	2.2	0.2	-1.8	0.4	-1.2	1.9	2.1
Hair/balding pattern: Pattern 3	0.1	0.2	0.8	0.4	-0.9	-0.4	-0.1	-0.2	0.1	0.2
Number of live births	0.7	0.9	2.6	1.6	-1.1	-1.6	-0.0	-0.3	0.1	0.4
Forced expiratory volume in 1-second (FEV1)	1.2	4.0	6.8	2.6	-0.2	-2.0	1.1	-2.4	2.2	2.3
Pulse rate	0.5	0.8	4.4	-0.5	0.7	-0.0	-2.1	-0.4	0.5	0.1
Happiness	1.3	1.6	4.4	-1.4	-0.1	1.4	-2.1	1.4	-0.6	-0.5
Noisy workplace	0.8	1.0	4.4	0.3	-1.1	-1.0	-2.1	0.1	0.3	0.3
Qualifications: A levels/AS levels or equivalent	1.1	2.5	4.4	2.1	-2.1	-1.5	1.0	-1.8	1.1	0.9
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.1	2.5	1.2	0.4	-0.9	0.4	-0.9	1.6	1.4
Mouth/teeth dental problems: Dentures	0.3	0.5	2.1	0.7	-1.4	-0.4	0.0	-0.1	0.5	0.4
Asthma	0.4	0.8	1.5	-0.2	1.2	1.1	1.2	1.0	0.3	0.4
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.6	0.2	0.2	0.5	-0.8	0.7	0.5	0.6
Medication: Cholesterol lowering	0.8	1.3	4.9	-0.4	0.1	0.9	-2.2	1.0	-0.9	-1.1
Depression (self-reported)	0.6	0.7	3.3	-0.2	-0.7	0.9	1.8	0.4	0.1	0.2
Medication: Lansoprazole	0.7	0.8	2.8	0.3	0.8	0.8	1.7	1.1	-0.3	-0.3
Prospective memory result	0.4	0.5	1.1	-0.4	-0.1	-1.0	-1.0	-0.7	0.8	0.5
Lung cancer (father)	0.2	0.3	1.2	0.2	0.2	-1.1	-0.7	0.1	-0.2	-0.0
Illnesses of mother	0.6	0.7	2.1	-0.0	-0.9	-0.3	-0.5	-0.9	1.4	1.1
Forced expiratory volume in 1-second (FEV1), Best measure	1.0	3.2	4.6	2.0	0.2	-1.9	1.5	-2.1	2.0	2.0
Pulse wave Arterial Stiffness index	1.0	1.2	3.7	1.4	0.1	-1.9	-0.9	-1.1	0.4	0.7
Impedance of arm (left)	0.0	0.2	0.7	0.3	-0.2	0.8	0.5	-0.0	-0.1	-0.1
Arm fat mass (right)	0.6	2.3	3.6	1.6	1.5	-1.0	1.9	-0.7	1.7	1.8
Trunk predicted mass	1.6	9.2	25.7	2.4	1.2	-5.1	0.8	-3.3	3.2	3.1
Standing height	1.3	13.3	38.4	3.1	1.2	-6.2	0.3	-4.2	3.8	3.3
Length of working week for main job	0.3	0.3	0.8	0.0	-0.5	-0.9	0.4	0.2	-0.7	-0.5
Exposure to tobacco smoke at home	0.9	1.0	2.4	0.9	-0.7	-1.3	1.5	-0.7	0.8	0.6
Breastfed as a baby	1.2	1.5	5.9	1.1	-2.4	-0.1	-0.4	-1.3	0.9	0.8
Tense / ‘highly strung’	0.8	1.4	4.1	-0.8	-1.0	1.7	-0.8	2.0	-0.2	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.3	4.0	-0.6	-1.4	1.6	0.0	2.0	-0.2	0.1
Hair/balding pattern: Pattern 4	0.7	1.7	3.2	1.7	0.4	-1.4	-0.9	-1.8	1.2	1.4
Birth weight of first child	1.6	2.9	4.9	1.4	-1.0	-2.1	0.3	-2.1	2.2	1.8
Peak expiratory flow (PEF)	0.2	0.5	1.5	-0.6	0.4	0.9	1.2	0.0	-0.7	-0.7
Pulse wave reflection index	1.8	2.3	8.9	1.6	-0.5	-3.0	0.3	-1.3	0.9	1.3
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.4	-0.6	-0.7	1.2	0.2	0.7	-1.0	-0.1
Loud music exposure frequency	0.5	0.6	1.7	1.3	0.5	-0.2	-0.6	-0.6	0.8	0.8
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	4.0	0.1	-2.0	0.1	0.0	-0.5	0.0	-0.0
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.0	-1.0	0.5	0.3	0.1	0.8	-0.6	-1.0
Blood clot in the leg (DVT)	1.3	1.6	2.7	1.5	-0.9	-1.6	0.1	-1.2	1.5	1.4
Medication: Paracetamol	0.8	1.3	4.6	0.1	-0.1	1.5	0.3	2.2	-1.2	-0.8
Headache pain in last month	0.4	0.7	2.6	0.5	-0.0	0.7	0.9	1.6	-0.6	-0.7
Medication for cholesterol, blood pressure or diabetes	0.6	0.9	2.8	0.2	-0.0	-1.1	1.7	-1.2	0.8	0.8
Glaucoma (self-reported)	1.0	1.2	3.3	-0.4	1.8	1.2	-0.7	0.5	1.4	0.7
Gout (self-reported)	1.7	2.4	4.7	-1.5	0.8	-0.8	2.2	1.6	-1.7	-1.7
Hypothyroidism/myxoedema (self-reported)	3.4	6.6	12.2	-3.3	0.3	2.6	-0.6	3.5	-2.7	-2.9
Medication: Amlodipine	4.0	5.7	11.2	-2.9	1.1	1.5	-0.2	2.4	-3.3	-3.3
Medication: Ventolin 100micrograms inhaler	1.1	1.4	6.3	-0.6	2.5	1.3	1.0	0.7	-0.3	-0.1
Birth weight	0.4	0.8	2.9	-1.2	-1.7	-0.2	0.3	0.2	-0.6	-0.8
Chronic bronchitis/emphysema (mother)	0.7	0.9	2.8	-0.2	1.5	-0.9	1.7	0.2	-0.0	-0.4
High blood pressure (siblings)	0.2	0.3	0.6	-0.5	-0.3	-0.0	-0.3	0.5	-0.8	-0.7
Forced vital capacity (FVC), Best measure	1.2	4.5	7.4	2.5	0.2	-2.4	1.1	-2.0	2.6	2.7
Body fat percentage	0.2	0.9	2.9	0.6	1.7	1.0	0.9	1.1	0.3	0.3
Leg fat percentage (right)	0.6	2.0	6.0	-0.8	1.7	1.5	0.5	2.4	-0.9	-1.0
Arm fat-free mass (right)	0.8	4.0	12.2	1.6	1.5	-3.5	0.0	-1.9	2.0	1.9
Exposure to tobacco smoke outside home	0.4	0.6	1.3	-0.4	0.7	1.2	0.9	1.0	-0.4	0.1
Comparative body size at age 10	0.5	1.5	2.8	0.8	-1.6	-0.7	0.4	-1.3	1.6	1.7
Number of full brothers	0.2	0.3	0.8	0.9	-0.6	0.1	0.2	-0.3	0.4	0.6
Worry too long after embarrassment	0.3	0.6	1.7	-0.4	-0.6	-0.1	1.3	1.1	-0.4	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.3	-0.2	0.3	0.8	0.8	1.1	0.8	0.5
Wheeze or whistling in the chest in last year	0.8	1.3	4.3	-0.2	2.1	1.3	0.8	1.4	-0.7	-0.1
Number of children fathered	0.9	1.0	2.4	-0.4	-0.0	0.9	-0.7	1.1	-1.4	-1.6
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	0.8	0.6	-0.5	0.1	-0.5	0.9	-0.3	-0.8
Age at first live birth	0.8	1.4	2.8	0.9	-1.7	-1.3	1.1	-1.7	0.2	0.2
Pulse wave peak to peak time	1.0	1.1	2.8	-1.5	0.1	1.7	0.9	1.1	-0.5	-0.8
Health satisfaction	0.4	0.5	2.7	1.6	0.3	-0.1	0.2	0.1	0.2	0.9
Shortness of breath walking on level ground	1.9	2.2	4.6	-1.4	0.7	1.8	-0.4	2.2	-1.6	-1.5
Qualifications: College or University degree	0.4	1.3	2.8	0.2	-1.0	-0.4	1.2	-1.6	1.7	1.0
Eye problems/disorders: None of the above	2.0	2.3	5.7	-0.4	-2.4	0.9	2.3	1.0	-1.3	-1.1
Mouth/teeth dental problems: Loose teeth	0.8	0.9	3.8	-0.3	-1.9	-0.8	-1.0	-0.2	-0.7	-0.5
Emphysema/chronic bronchitis	0.5	0.6	1.5	0.2	-0.1	-0.8	-0.6	-1.2	1.0	0.8
Medication for pain relief, constipation, heartburn	0.9	1.6	7.1	0.6	-0.9	-1.1	0.4	-2.7	1.0	0.7
Neck or shoulder pain in last month	0.6	0.9	2.2	1.0	-1.3	0.2	0.1	-0.3	0.9	1.5
Medication: Blood pressure	1.2	2.1	3.3	-1.1	0.0	1.8	-1.5	1.8	-1.7	-1.4
Angina (self-reported)	2.5	3.3	5.2	-1.8	1.3	1.6	-1.0	2.3	-2.1	-2.3
Migraine (self-reported)	1.1	1.3	3.7	-0.7	-0.1	1.0	-0.7	1.9	-1.3	-1.3
Medication: Ibuprofen	0.3	0.4	1.0	0.5	0.4	0.3	-1.0	0.2	0.8	0.8
Medication: Allopurinol	2.0	2.6	5.9	-1.8	0.7	0.0	0.8	1.8	-2.2	-2.4
Medication: Omeprazole	1.0	1.1	3.0	0.3	1.7	0.2	1.6	1.1	-1.0	-0.4
Medication: Seretide 50 evohaler	0.5	0.5	1.7	-1.0	0.4	0.2	-1.3	0.4	-0.4	-0.7
Mean time to correctly identify matches	2.4	4.5	9.2	2.7	-0.4	-1.1	-0.2	-2.6	3.0	2.7
Heart disease (mother)	4.9	6.0	11.4	-2.5	-0.3	1.7	1.5	2.9	-3.2	-3.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.4	-0.8	0.9	0.2	1.2	0.6	-0.1	-0.2
Whole body fat mass	0.4	1.6	3.3	1.4	1.8	-0.6	1.1	-0.2	1.4	1.4
Leg fat mass (right)	0.2	1.0	2.9	0.9	1.7	-0.3	1.1	0.3	0.9	0.9
Arm predicted mass (right)	0.7	3.6	10.8	1.4	1.5	-3.3	-0.0	-1.8	1.9	1.9
Pulse rate, automated reading	0.4	1.2	2.6	-1.0	1.2	1.4	-1.6	1.1	-0.0	-0.5
Alcohol intake frequency.	0.9	2.1	5.2	1.6	0.8	-1.2	-0.8	-0.7	1.9	2.3
Comparative height size at age 10	2.3	12.5	19.8	3.7	0.1	-4.4	-1.4	-4.4	4.2	3.9
Number of full sisters	0.2	0.2	0.6	0.6	-0.7	-0.2	0.8	0.0	-0.5	-0.1
Suffer from ‘nerves’	4.1	6.4	18.4	-2.3	0.9	3.1	0.1	4.3	-2.3	-2.3
Overall health rating	0.4	0.8	3.4	1.1	1.9	-0.0	0.3	0.4	0.4	0.7
Chest pain or discomfort	0.6	0.9	3.8	0.2	-1.2	0.9	2.0	0.2	0.0	0.3
Had major operations	0.7	0.8	2.4	-0.9	-1.6	1.1	-0.5	0.4	-0.4	-0.7
Age at last live birth	2.3	3.3	6.6	2.2	-1.6	-2.6	0.7	-2.2	1.3	1.6
Family relationship satisfaction	1.3	1.6	2.8	-0.5	1.2	1.7	-1.5	1.5	-1.1	-1.1
Leg pain on walking	0.5	0.6	1.9	0.1	0.5	1.2	1.4	0.5	-0.3	-0.2
Qualifications: NVQ or HND or HNC or equivalent	0.8	1.0	6.2	-0.1	-2.5	0.3	-0.1	0.8	-0.2	-0.1
Commuting to job workplace: Car/motor vehicle	0.6	0.7	1.6	0.8	1.3	-1.1	0.8	-0.5	0.6	0.7
Illness, injury, bereavement, stress in last 2 years	4.1	5.0	10.4	-2.8	0.0	1.2	-0.6	2.3	-3.1	-3.2
Medication: Aspirin	2.3	3.1	5.2	-2.2	1.1	1.4	-0.2	2.3	-2.1	-1.9
Supplements: Vitamin C	1.5	1.8	2.8	1.6	0.7	-1.7	-0.2	-1.7	1.5	1.4
Knee pain experienced in last month	0.8	1.3	2.9	1.7	1.3	-0.8	-0.3	-0.7	1.2	1.3
Hypertension (Self-reported)	0.5	1.4	4.1	-1.1	0.2	0.9	-2.0	1.6	-1.0	-0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.3	2.7	5.1	-1.9	1.3	0.5	0.4	2.3	-2.2	-1.9
Illnesses of father: Heart disease	0.9	1.2	2.1	-1.2	0.2	1.4	-0.0	1.1	-1.5	-1.3
Illnesses of siblings: Diabetes	0.2	0.2	0.7	0.5	0.9	0.5	-0.3	0.5	-0.3	-0.2
Smoking status: Previous	0.8	1.1	2.7	-0.1	-1.2	1.5	0.3	1.6	-0.6	-1.1
Forced expiratory volume in 1-second (FEV1), predicted	1.2	2.5	5.0	2.2	-0.8	-2.2	0.8	-1.3	1.6	1.5
Whole body fat-free mass	1.6	9.2	22.2	2.6	1.5	-4.7	1.0	-3.3	3.3	3.3
Leg fat-free mass (right)	2.0	10.8	17.6	3.2	1.5	-4.2	1.4	-3.8	3.7	3.9
Arm fat percentage (left)	0.4	1.8	3.7	1.4	1.3	0.1	1.9	-0.3	1.4	1.7
Average weekly red wine intake	0.7	1.1	2.8	0.7	-0.7	-0.9	1.4	-1.7	0.9	0.7
Handedness (chirality/laterality): Left-handed	1.8	2.2	4.4	2.1	1.2	-0.1	0.9	-1.4	2.0	1.8
Mood swings	2.9	5.2	16.2	-2.3	0.7	2.8	-0.1	4.0	-1.9	-1.7
Loneliness, isolation	0.8	1.2	3.7	-0.7	0.6	0.9	1.0	1.9	-0.9	-0.9
Long-standing illness, disability or infirmity	0.4	0.7	3.4	0.1	1.9	-0.1	-0.7	0.9	-0.1	-0.1
Ever had bowel cancer screening	0.9	1.1	4.3	2.1	-0.7	-0.8	1.4	-0.0	0.4	0.4
Diabetes diagnosed by doctor	0.4	0.7	3.2	-0.3	0.8	0.4	-1.8	0.7	-0.3	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.3	6.4	-0.7	-2.5	1.0	0.5	0.4	-0.5	-0.5
Friendships satisfaction	0.6	0.8	2.5	-0.1	1.5	-0.3	-1.6	0.6	0.4	0.5
Qualifications: nursing, teaching	1.0	1.6	3.3	1.2	-1.2	-1.1	0.7	-1.8	1.2	1.3
Commuting to job workplace: Walk	0.9	1.0	2.2	-1.5	-0.4	1.5	-0.2	0.9	-0.9	-0.8
Eye problems/disorders: Cataract	2.9	3.4	5.3	1.5	2.0	-2.3	-1.7	-1.9	1.7	1.7
Mouth/teeth dental problems: Mouth ulcers	4.4	7.0	11.6	3.4	-1.7	-2.6	0.7	-2.9	2.8	3.4
Medication for cholesterol	2.1	3.2	7.8	2.5	-0.4	-0.7	-0.5	-2.8	1.8	2.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	0.9	1.9	1.2	-1.4	-1.1	0.8	-0.8	0.6	0.6
Back pain experienced in last month	1.4	2.0	3.8	-1.9	-0.1	0.9	-0.0	2.0	-1.7	-1.6
Mineral and other dietary supplements	1.2	1.6	4.3	-1.6	2.1	0.8	-0.1	1.2	-1.2	-1.0
Breast cancer (self-reported)	0.6	0.8	1.6	1.3	-1.1	-0.8	0.7	-0.5	0.7	0.7
Asthma (self-reported)	0.4	0.7	1.3	-0.3	1.1	1.1	1.1	1.0	0.4	0.5
Osteoporosis (self-reported)	1.9	2.4	7.3	2.7	-0.6	-1.3	0.8	-1.0	1.5	1.8
Osteoarthritis (self-reported)	1.2	1.6	6.3	2.5	0.6	-1.6	-0.1	-0.8	0.5	1.0
Medication: Aspirin	1.6	2.1	3.7	-1.9	1.2	1.0	-0.0	1.8	-1.7	-1.6
Medication: Gliclazide	0.1	0.2	0.3	-0.5	0.5	0.6	0.2	0.5	0.0	-0.2
Illnesses of father: None of the above (group 1)	2.6	3.3	6.2	1.9	-0.7	-2.5	0.6	-2.0	2.1	2.0
Smoking status: Current	0.2	0.3	0.7	-0.3	0.5	0.5	-0.5	0.1	0.6	0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	1.3	0.6	-1.1	0.5	1.1	-0.7	0.2	0.5
Whole body water mass	1.5	8.8	20.6	2.5	1.5	-4.5	1.0	-3.3	3.2	3.2
Leg predicted mass (right)	2.1	11.1	18.2	3.3	1.5	-4.3	1.4	-3.8	3.8	4.0
Arm fat mass (left)	0.6	2.6	4.0	1.7	1.4	-1.2	2.0	-0.9	1.8	2.0
Number of self-reported non-cancer illnesses	0.4	0.7	2.4	-0.9	0.7	0.6	-1.0	1.6	0.0	-0.1
Average weekly champagne plus white wine intake	1.8	2.4	5.0	-2.2	1.5	1.4	-0.5	1.2	-1.5	-1.9
Miserableness	1.5	2.6	5.6	-2.1	0.1	2.4	-0.7	2.1	-1.4	-1.3
Guilty feelings	3.5	5.3	13.3	-2.2	0.3	3.2	-0.3	3.7	-2.0	-2.1
Wears glasses or contact lenses	0.1	0.2	0.6	-0.1	0.1	-0.8	-0.7	0.1	0.1	-0.2
Ever taken oral contraceptive pill	1.0	1.2	2.7	-0.6	-0.6	0.9	-1.0	1.6	-1.2	-1.2
Hearing aid user	5.5	6.3	10.7	3.0	1.7	-2.1	0.3	-2.5	3.3	3.2
Mother’s age at death	1.8	2.2	4.6	1.0	-1.1	-1.8	-2.1	-1.7	1.3	1.1
Financial situation satisfaction	0.4	0.5	1.2	-1.1	0.1	0.6	-0.9	0.9	-0.1	-0.4
Tinnitus: Yes, now most or all of the time	1.5	1.7	4.9	2.2	1.7	-1.1	-0.6	-0.7	1.0	1.1
Commuting to job workplace: Public transport	1.1	1.3	3.5	1.3	-0.2	0.2	0.4	-1.9	1.3	1.4
Eye problems/disorders: Glaucoma	1.3	1.5	3.9	-1.3	2.0	1.7	-0.8	1.2	0.2	-0.4
Medication: Blood pressure	1.7	3.2	7.8	-2.1	0.8	1.1	-1.5	2.8	-1.7	-1.7
Pain type(s) experienced in last month: Hip pain	0.8	1.1	1.9	-0.8	0.3	-0.8	1.4	1.2	-1.2	-1.2
Supplements: Fish oil (including cod liver oil)	0.8	1.1	2.9	1.7	-0.9	-0.7	0.6	-1.3	0.8	0.8
High cholesterol (Self-reported)	0.2	0.3	0.6	-0.8	0.2	-0.3	-0.1	0.8	-0.3	-0.7
Medication: Bendroflumethiazide	1.0	1.6	4.6	0.3	0.2	1.8	-2.1	1.5	-0.9	-0.4
Medication: Paracetamol	1.1	1.6	4.8	0.2	0.4	1.7	-0.1	2.2	-1.5	-1.1
Medication: Lisinopril	0.5	0.7	1.9	-0.9	0.2	0.4	-1.4	0.6	-0.8	-1.0
Medication: Atorvastatin	0.8	1.0	2.0	-1.4	0.9	1.1	-0.3	1.0	-1.1	-1.0
Illnesses of father: High blood pressure	2.5	3.1	6.0	-2.0	0.2	2.3	-0.5	2.4	-1.9	-1.7
Alcohol drinker status: Never	0.2	0.3	0.7	-0.6	0.4	0.8	0.7	0.1	0.3	0.4
Ever smoked	0.3	0.6	2.0	0.0	-0.7	0.6	0.4	1.4	-0.8	-0.7
Basal metabolic rate	1.5	8.1	18.0	2.5	1.6	-4.2	1.1	-3.0	3.1	3.2
Leg fat percentage (left)	0.5	1.7	5.3	-0.7	1.4	1.5	0.3	2.3	-0.9	-1.0
Arm fat-free mass (left)	0.8	4.3	11.8	1.8	1.2	-3.4	0.5	-2.0	2.2	2.1
Number of operations (self-reported)	1.0	1.5	4.9	1.0	-2.2	-1.1	-1.0	-0.1	1.2	1.0
Average weekly beer plus cider intake	1.2	1.7	3.5	-0.8	-0.7	1.9	-0.2	1.7	-1.7	-1.2
Irritability	1.1	1.9	5.3	-1.5	0.7	2.1	-1.0	2.3	-0.0	-0.3
Risk taking	0.4	0.5	2.3	0.4	0.1	-0.4	1.5	-0.4	-0.6	-0.7
Ever had prostate specific antigen (PSA) test	1.6	1.9	3.5	1.4	-0.7	-1.2	-0.7	-1.9	1.7	1.6
Fractured/broken bones in last 5 years	2.8	3.6	6.6	2.1	-0.9	-2.6	-1.0	-1.6	2.0	2.4
Age started oral contraceptive pill	1.8	2.2	4.0	1.8	0.2	-1.6	-0.7	-1.3	2.0	1.8
Diastolic blood pressure, automated reading	1.1	3.3	7.0	-1.7	1.8	2.6	-0.4	2.5	-1.4	-1.2
Ever depressed for a whole week	2.1	2.6	4.6	-2.1	-1.2	1.4	0.6	2.2	-1.5	-1.7
Unable to work because of sickness or disability	1.9	2.5	5.0	1.6	-1.2	-1.5	2.2	-1.4	1.4	1.4
Commuting to job workplace: Cycle	2.6	3.2	7.2	-2.1	-2.7	1.4	0.2	1.1	-1.8	-2.0
Myopia	0.5	0.7	1.3	0.5	0.6	-0.5	0.9	0.6	-1.1	-1.1
Vascular/heart problems diagnosed by doctor	0.4	1.2	3.6	1.1	-0.3	-0.4	1.9	-1.5	0.8	0.6
Cholesterol lowering medication	0.2	0.3	1.3	-0.2	-0.2	-1.1	0.6	0.5	0.4	-0.0
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	2.8	1.5	1.5	-0.8	1.7	0.0	0.0	0.6
Pain experienced in last month	0.1	0.1	0.8	-0.2	0.1	0.0	0.1	-0.9	-0.2	-0.1
Supplements: Calcium	0.4	0.4	1.3	1.1	-1.0	-0.7	0.0	0.4	0.1	0.3
Basal cell carcinoma (self-reported)	2.4	2.8	15.7	-0.9	-1.0	-0.8	-4.0	-0.9	0.8	0.5
Heart attack/myocardial infarction (self-reported)	1.5	1.9	3.7	-1.9	0.8	1.1	0.0	1.3	-1.6	-1.9
Deep venous thrombosis (DVT) (self-reported)	1.0	1.3	2.9	1.4	-0.8	-1.7	-0.2	-1.2	1.1	1.1
Heart disease (siblings)	0.9	1.1	2.8	-0.2	0.5	0.8	-0.1	1.4	-1.7	-1.5
Alcohol drinker status: Previous	0.9	1.0	4.4	0.0	2.1	-0.3	-0.9	1.1	-0.5	-0.4
Pack years of smoking	0.5	0.8	1.9	0.6	0.6	-1.4	-0.6	-1.0	0.9	0.7
Impedance of whole body	0.7	3.3	5.9	-1.4	-0.1	2.4	-0.6	2.3	-2.0	-2.4
Leg fat mass (left)	0.3	1.1	2.5	1.2	1.6	-0.5	1.0	0.0	1.0	1.1
Arm predicted mass (left)	0.8	4.1	12.1	1.7	1.3	-3.5	0.7	-1.8	2.0	2.0