Best TWAS P=2.35e-16 · Best GWAS P=3.58e-16 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | METSIM | Adipose | CADM2 | 0.05 | 0.06 | lasso | 10 | 0.06 | 1.3e-09 | -6.3 | -6.2 | 7.1e-10 | 0.67 | 0.95 | 0.05 | FALSE |
| 2 | The Cancer Genome Atlas | Lung Adenocarcinoma | CADM2 | 0.08 | 0.04 | lasso | 4 | 0.05 | 2.1e-06 | -8.1 | -8.2 | 2.4e-16 | 0.96 | 0.02 | 0.98 | TRUE |
| 3 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | CADM2 | 0.05 | 0.03 | lasso | 3 | 0.04 | 5.0e-05 | -8.2 | -7.8 | 4.2e-15 | 0.97 | 0.02 | 0.98 | FALSE |
| 4 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | CADM2 | 0.14 | 0.05 | blup | 339 | 0.09 | 2.7e-04 | -7.9 | -6.5 | 8.4e-11 | 0.84 | 0.04 | 0.84 | FALSE |