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chr3:135,173,458-137,261,517

Best TWAS P=1.97e-11 · Best GWAS P=1.65e-10 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	PCCB	0.09	0.19	lasso	7	0.18	1.2e-21	-6.2	-6.0	1.8e-09	0.94	0.04	0.96	FALSE
2	GTEx	Adipose Subcutaneous	PCCB	0.07	0.05	enet	4	0.02	6.6e-03	5.6	-5.6	1.7e-08	0.73	0.08	0.81	FALSE
3	GTEx	Adrenal Gland	PCCB	0.17	0.09	lasso	6	0.10	2.1e-04	-6.0	-5.2	2.0e-07	0.95	0.03	0.93	FALSE
4	GTEx	Artery Coronary	RP11-85F14.5	0.15	0.01	lasso	4	0.00	2.3e-01	-6.1	-6.3	2.9e-10	0.87	0.04	0.80	FALSE
5	GTEx	Brain Caudate basal ganglia	PCCB	0.11	0.01	enet	12	0.01	2.1e-01	-6.0	-6.2	6.5e-10	0.83	0.04	0.52	FALSE
6	GTEx	Brain Frontal Cortex BA9	PCCB	0.11	0.01	enet	9	0.01	1.7e-01	5.7	-5.2	2.6e-07	0.78	0.05	0.61	FALSE
7	GTEx	Breast Mammary Tissue	PCCB	0.08	0.05	lasso	3	0.03	1.3e-02	5.6	-6.0	1.8e-09	0.77	0.06	0.81	FALSE
8	GTEx	Cells Transformed fibroblasts	PCCB	0.10	0.09	lasso	3	0.07	5.0e-06	-6.1	-5.9	3.4e-09	0.99	0.03	0.97	FALSE
9	GTEx	Colon Transverse	PCCB	0.07	0.06	lasso	3	0.04	7.7e-03	-5.9	-5.5	3.4e-08	0.97	0.03	0.92	FALSE
10	GTEx	Esophagus Mucosa	PCCB	0.10	0.12	lasso	3	0.11	4.8e-08	-6.1	-5.9	3.8e-09	0.91	0.04	0.96	FALSE
11	GTEx	Heart Left Ventricle	PCCB	0.08	0.05	enet	7	0.01	7.2e-02	-5.2	-5.9	3.8e-09	0.88	0.05	0.93	FALSE
12	GTEx	Lung	PCCB	0.07	0.04	lasso	3	0.03	4.2e-03	-6.1	-6.0	2.5e-09	0.95	0.03	0.93	FALSE
13	GTEx	Muscle Skeletal	PCCB	0.09	0.09	enet	13	0.11	1.2e-10	-6.4	-5.9	4.2e-09	0.88	0.03	0.97	FALSE
14	GTEx	Testis	PCCB	0.26	0.22	lasso	10	0.22	4.7e-10	-6.1	-5.7	9.5e-09	0.91	0.04	0.96	FALSE
15	METSIM	Adipose	PCCB	0.07	0.06	lasso	12	0.06	4.1e-09	-6.2	-5.6	2.6e-08	0.89	0.03	0.97	FALSE
16	YFS	Blood	MSL2	0.02	0.04	lasso	2	0.03	9.9e-11	5.5	-5.5	3.6e-08	0.45	0.59	0.41	FALSE
17	YFS	Blood	PCCB	0.13	0.20	lasso	9	0.20	1.3e-64	-6.0	-6.0	2.5e-09	0.92	0.14	0.86	FALSE
18	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	PCCB	0.05	0.03	blup	53	0.03	1.2e-03	-6.1	-5.4	6.7e-08	0.89	0.01	0.93	FALSE
19	The Cancer Genome Atlas	Colon Adenocarcinoma	PCCB	0.11	0.03	blup	54	0.04	2.3e-03	-6.0	-6.0	1.7e-09	0.92	0.01	0.72	FALSE
20	The Cancer Genome Atlas	Esophageal Carcinoma	PCCB	0.15	0.03	blup	54	0.05	9.6e-03	-5.2	-6.5	6.1e-11	0.88	0.01	0.64	FALSE
21	The Cancer Genome Atlas	Glioblastoma Multiforme	PCCB	0.10	0.03	blup	53	0.02	5.8e-02	-5.2	-6.0	1.5e-09	0.90	0.01	0.67	FALSE
22	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	MSL2	0.07	0.02	enet	6	0.03	1.7e-04	-5.3	-5.8	8.7e-09	0.78	0.03	0.60	FALSE
23	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PCCB	0.12	0.05	enet	7	0.09	9.7e-11	-5.4	-5.1	3.0e-07	0.82	0.02	0.98	FALSE
24	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	STAG1	0.04	0.02	lasso	3	0.02	4.1e-03	5.1	-6.2	5.9e-10	0.76	0.05	0.85	FALSE
25	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PCCB	0.05	0.05	blup	54	0.05	3.5e-06	-6.1	-5.7	1.6e-08	0.87	0.01	0.99	FALSE
26	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PPP2R3A	0.05	0.02	enet	8	0.02	1.1e-03	-5.3	-5.3	1.2e-07	0.75	0.04	0.53	FALSE
27	The Cancer Genome Atlas	Brain Lower Grade Glioma	PCCB	0.06	0.05	lasso	2	0.03	1.2e-04	-6.0	-5.5	3.8e-08	0.90	0.01	0.99	FALSE
28	The Cancer Genome Atlas	Lung Adenocarcinoma	PCCB	0.11	0.10	lasso	3	0.10	1.3e-11	-6.0	-5.8	6.6e-09	0.92	0.01	0.99	FALSE
29	The Cancer Genome Atlas	Lung Adenocarcinoma	STAG1	0.02	0.02	enet	6	0.02	3.5e-03	-6.1	-6.1	9.5e-10	0.92	0.04	0.81	FALSE
30	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	MSL2	0.04	0.02	blup	35	0.01	1.9e-02	-5.4	-6.3	2.6e-10	0.82	0.02	0.76	FALSE
31	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	PCCB	0.13	0.10	lasso	4	0.10	2.4e-11	-5.2	-5.2	1.9e-07	0.88	0.02	0.98	FALSE
32	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	STAG1	0.05	0.00	blup	151	0.01	2.9e-02	-6.2	-6.7	2.0e-11	0.96	0.02	0.98	TRUE
33	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	MSL2	0.09	0.01	blup	35	0.02	8.1e-03	5.7	-6.2	7.2e-10	0.84	0.01	0.80	FALSE
34	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	PCCB	0.12	0.07	enet	3	0.06	1.0e-04	-5.4	-5.3	1.0e-07	0.88	0.02	0.96	FALSE
35	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	PCCB	0.12	0.02	lasso	5	0.02	6.7e-02	-6.1	-5.4	5.7e-08	0.87	0.01	0.82	FALSE
36	The Cancer Genome Atlas	Prostate Adenocarcinoma	PCCB	0.06	0.02	lasso	2	0.03	2.3e-04	4.8	-5.6	1.8e-08	0.80	0.03	0.93	FALSE
37	The Cancer Genome Atlas	Soft Tissue Sarcoma	PCCB	0.14	0.10	enet	6	0.10	1.0e-06	-6.0	-6.1	9.3e-10	0.92	0.01	0.99	FALSE
38	The Cancer Genome Atlas	Soft Tissue Sarcoma	STAG1	0.06	0.06	lasso	1	0.04	2.0e-03	-6.3	-6.3	2.2e-10	0.95	0.02	0.79	FALSE
39	The Cancer Genome Atlas	Stomach Adenocarcinoma	PCCB	0.07	0.04	lasso	1	0.02	1.1e-02	-6.1	-6.0	1.4e-09	0.92	0.01	0.96	FALSE
40	The Cancer Genome Atlas	Thyroid Carcinoma	PCCB	0.06	0.03	enet	8	0.03	2.3e-04	-6.1	-5.7	1.5e-08	0.88	0.01	0.99	FALSE