Best TWAS P=4.81e-09 · Best GWAS P=2.34e-10 conditioned to 0.0113
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adrenal Gland | LRRC4 | 0.20 | 0.01 | lasso | 7 | 0.05 | 5.2e-03 | -4.4 | 5.1 | 2.8e-07 | -0.62 | 0.14 | 0.25 | FALSE |
| 2 | GTEx | Brain Cerebellar Hemisphere | LRRC4 | 0.14 | 0.09 | lasso | 7 | 0.04 | 3.4e-02 | -6.3 | -5.3 | 9.0e-08 | 0.89 | 0.04 | 0.72 | FALSE |
| 3 | GTEx | Brain Cortex | GCC1 | 0.22 | 0.13 | lasso | 5 | 0.05 | 1.9e-02 | 4.8 | -5.3 | 1.4e-07 | 0.55 | 0.16 | 0.38 | FALSE |
| 4 | GTEx | Esophagus Gastroesophageal Junction | SND1 | 0.21 | 0.05 | enet | 26 | 0.05 | 7.9e-03 | -4.4 | 5.9 | 4.8e-09 | -0.66 | 0.12 | 0.74 | TRUE |
| 5 | GTEx | Skin Sun Exposed Lower leg | SND1 | 0.10 | 0.08 | lasso | 4 | 0.06 | 1.2e-05 | -6.3 | 5.7 | 1.5e-08 | -0.94 | 0.04 | 0.96 | FALSE |
| 6 | METSIM | Adipose | SND1 | 0.06 | 0.03 | blup | 602 | 0.04 | 1.5e-06 | -3.5 | 5.7 | 1.1e-08 | -0.72 | 0.16 | 0.84 | FALSE |
| 7 | YFS | Blood | GCC1 | 0.03 | 0.04 | lasso | 6 | 0.04 | 1.8e-12 | 4.8 | -5.1 | 2.9e-07 | 0.48 | 0.89 | 0.11 | FALSE |
| 8 | The Cancer Genome Atlas | Lung Adenocarcinoma | LRRC4 | 0.02 | 0.03 | lasso | 2 | 0.02 | 2.7e-03 | 5.3 | -5.3 | 1.3e-07 | 0.51 | 0.00 | 0.95 | TRUE |