[Hub]/) : Traits : Tense / 'highly strung' :

chr5:64,115,004-65,711,805

Best TWAS P=1.57e-09 · Best GWAS P=1.06e-09 conditioned to 0.143

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous PPWD1 0.16 0.18 lasso 5 0.17 6.5e-14 5.4 5.1 2.7e-07 0.94 0.25 0.75 FALSE
2 GTEx Adrenal Gland PPWD1 0.12 0.10 lasso 3 0.10 1.7e-04 5.4 5.2 2.4e-07 0.92 0.15 0.80 FALSE
3 GTEx Adrenal Gland TRIM23 0.09 0.01 enet 19 0.04 1.8e-02 5.4 5.5 3.5e-08 0.81 0.07 0.70 FALSE
4 GTEx Artery Aorta PPWD1 0.21 0.22 lasso 4 0.20 1.7e-11 5.4 5.8 6.7e-09 0.95 0.27 0.73 FALSE
5 GTEx Artery Aorta TRIM23 0.10 0.10 lasso 11 0.09 1.3e-05 5.4 5.4 7.0e-08 0.97 0.17 0.82 FALSE
6 GTEx Artery Coronary PPWD1 0.23 0.05 enet 17 0.15 7.0e-06 5.4 5.2 2.4e-07 0.77 0.16 0.67 FALSE
7 GTEx Artery Tibial PPWD1 0.16 0.18 lasso 7 0.17 2.1e-13 5.4 5.4 6.0e-08 0.97 0.15 0.85 FALSE
8 GTEx Artery Tibial TRIM23 0.06 0.05 enet 15 0.05 4.9e-05 5.4 5.2 1.6e-07 0.96 0.09 0.91 FALSE
9 GTEx Artery Tibial CTC-534A2.2 0.04 0.05 enet 4 0.01 3.1e-02 6.0 -6.0 1.6e-09 -0.91 0.03 0.87 TRUE
10 GTEx Brain Putamen basal ganglia PPWD1 0.14 0.16 lasso 1 0.09 3.4e-03 5.6 5.6 2.4e-08 0.97 0.09 0.78 FALSE
11 GTEx Breast Mammary Tissue PPWD1 0.13 0.12 lasso 6 0.10 1.0e-05 5.3 5.3 1.0e-07 0.94 0.13 0.87 FALSE
12 GTEx Cells Transformed fibroblasts PPWD1 0.12 0.14 lasso 2 0.13 5.7e-10 5.4 5.4 6.0e-08 0.97 0.21 0.79 FALSE
13 GTEx Colon Sigmoid PPWD1 0.12 0.14 enet 12 0.09 5.0e-04 5.3 5.4 7.9e-08 0.96 0.06 0.92 FALSE
14 GTEx Colon Transverse PPWD1 0.18 0.22 lasso 4 0.19 1.6e-09 5.4 5.5 3.7e-08 0.96 0.11 0.89 FALSE
15 GTEx Esophagus Mucosa PPWD1 0.11 0.08 lasso 1 0.06 5.7e-05 5.2 5.2 1.5e-07 0.96 0.15 0.85 FALSE
16 GTEx Esophagus Muscularis PPWD1 0.16 0.17 enet 36 0.16 4.0e-10 5.4 5.5 3.0e-08 0.88 0.24 0.76 FALSE
17 GTEx Heart Atrial Appendage PPWD1 0.10 0.07 lasso 1 0.04 7.6e-03 5.4 5.4 5.3e-08 0.97 0.04 0.90 FALSE
18 GTEx Lung PPWD1 0.06 0.11 lasso 1 0.09 1.9e-07 5.4 5.4 5.9e-08 0.97 0.26 0.74 FALSE
19 GTEx Lung TRIM23 0.09 0.06 lasso 3 0.05 9.2e-05 5.2 5.4 7.3e-08 0.94 0.24 0.70 FALSE
20 GTEx Muscle Skeletal PPWD1 0.06 0.03 enet 18 0.05 2.3e-05 6.0 5.3 8.6e-08 0.84 0.07 0.93 FALSE
21 GTEx Nerve Tibial PPWD1 0.28 0.37 lasso 8 0.37 5.0e-27 5.4 5.5 3.5e-08 0.96 0.26 0.74 FALSE
22 GTEx Nerve Tibial CTC-534A2.2 0.05 0.08 lasso 2 0.05 1.1e-04 6.0 -5.9 2.8e-09 -0.87 0.02 0.97 FALSE
23 GTEx Prostate CTC-534A2.2 0.21 0.02 lasso 4 0.02 1.3e-01 5.4 -5.2 2.2e-07 -0.94 0.07 0.62 FALSE
24 GTEx Skin Not Sun Exposed Suprapubic TRIM23 0.13 0.16 lasso 12 0.15 9.2e-09 5.3 5.4 8.4e-08 0.96 0.09 0.91 FALSE
25 GTEx Skin Sun Exposed Lower leg TRIM23 0.10 0.08 lasso 6 0.08 2.7e-07 5.4 5.4 6.2e-08 0.96 0.26 0.74 FALSE
26 GTEx Stomach PPWD1 0.09 0.09 lasso 5 0.08 1.2e-04 5.4 5.3 9.3e-08 0.96 0.11 0.83 FALSE
27 GTEx Testis TRIM23 0.10 0.14 lasso 8 0.13 3.0e-06 5.4 5.4 6.0e-08 0.97 0.25 0.73 FALSE
28 GTEx Thyroid PPWD1 0.15 0.24 lasso 7 0.24 1.5e-18 5.4 5.4 5.9e-08 0.97 0.28 0.72 FALSE
29 GTEx Thyroid TRIM23 0.08 0.07 lasso 4 0.04 3.2e-04 5.4 5.5 4.3e-08 0.97 0.06 0.94 FALSE
30 GTEx Uterus PPWD1 0.33 0.21 lasso 8 0.22 3.1e-05 5.3 5.8 5.8e-09 0.90 0.08 0.40 FALSE
31 METSIM Adipose CENPK 0.06 0.06 lasso 9 0.10 3.4e-15 6.0 5.3 1.4e-07 0.90 0.03 0.97 FALSE
32 METSIM Adipose PPWD1 0.08 0.14 enet 26 0.14 2.2e-20 5.6 5.5 4.2e-08 0.95 0.07 0.92 FALSE
33 METSIM Adipose TRIM23 0.06 0.08 lasso 5 0.07 7.5e-11 6.0 5.9 4.0e-09 1.00 0.02 0.98 FALSE
34 NTR Blood CENPK 0.04 0.08 lasso 10 0.08 1.3e-23 6.0 5.8 4.9e-09 1.00 0.02 0.98 FALSE
35 ROSMAP Brain Pre-frontal Cortex PPWD1 0.07 0.11 lasso 10 0.10 8.1e-13 5.5 5.4 6.6e-08 0.95 0.12 0.88 FALSE
36 ROSMAP Brain Pre-frontal Cortex SGTB 0.22 0.20 enet 20 0.32 1.6e-42 -3.7 5.1 2.9e-07 0.79 0.38 0.62 FALSE
37 ROSMAP Brain Pre-frontal Cortex CTC-534A2.2 0.07 0.06 lasso 5 0.05 1.5e-06 6.0 -5.7 1.1e-08 -0.80 0.01 0.99 FALSE
38 YFS Blood CENPK 0.23 0.53 bslmm 412 0.54 1.4e-214 6.0 5.6 2.2e-08 0.98 0.01 0.99 FALSE
39 The Cancer Genome Atlas Bladder Urothelial Carcinoma TRIM23 0.04 0.04 blup 62 0.05 4.6e-05 5.4 5.3 1.4e-07 0.93 0.04 0.96 FALSE
40 The Cancer Genome Atlas Breast Invasive Carcinoma PPWD1 0.01 0.01 blup 47 0.01 1.4e-03 6.0 5.3 1.4e-07 0.88 0.02 0.76 FALSE
41 The Cancer Genome Atlas Esophageal Carcinoma TRIM23 0.15 0.07 lasso 2 0.08 1.2e-03 5.4 5.4 5.7e-08 0.97 0.03 0.80 FALSE
42 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma C5orf44 0.02 0.03 lasso 1 0.02 4.6e-03 5.3 5.3 1.3e-07 0.94 0.02 0.82 FALSE
43 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma TRIM23 0.03 0.05 blup 62 0.05 4.4e-06 5.4 5.4 6.0e-08 0.97 0.08 0.92 FALSE
44 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma TRIM23 0.03 0.04 lasso 2 0.04 4.1e-05 5.4 5.5 2.9e-08 0.97 0.02 0.98 FALSE
45 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma PPWD1 0.05 0.06 blup 47 0.05 7.8e-04 5.4 5.1 3.1e-07 0.93 0.02 0.91 FALSE
46 The Cancer Genome Atlas Brain Lower Grade Glioma PPWD1 0.06 0.12 lasso 4 0.11 1.2e-12 6.0 5.9 4.3e-09 0.98 0.01 0.99 FALSE
47 The Cancer Genome Atlas Liver Hepatocellular Carcinoma C5orf44 0.09 0.01 blup 57 0.02 4.2e-02 -3.1 5.3 1.1e-07 0.89 0.02 0.49 FALSE
48 The Cancer Genome Atlas Prostate Adenocarcinoma PPWD1 0.03 0.03 blup 47 0.04 8.1e-05 5.4 5.5 2.9e-08 0.96 0.05 0.93 FALSE