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chr5:64,115,004-65,711,805

Best TWAS P=1.57e-09 · Best GWAS P=1.06e-09 conditioned to 0.143

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	PPWD1	0.16	0.18	lasso	5	0.17	6.5e-14	5.4	5.1	2.7e-07	0.94	0.25	0.75	FALSE
2	GTEx	Adrenal Gland	PPWD1	0.12	0.10	lasso	3	0.10	1.7e-04	5.4	5.2	2.4e-07	0.92	0.15	0.80	FALSE
3	GTEx	Adrenal Gland	TRIM23	0.09	0.01	enet	19	0.04	1.8e-02	5.4	5.5	3.5e-08	0.81	0.07	0.70	FALSE
4	GTEx	Artery Aorta	PPWD1	0.21	0.22	lasso	4	0.20	1.7e-11	5.4	5.8	6.7e-09	0.95	0.27	0.73	FALSE
5	GTEx	Artery Aorta	TRIM23	0.10	0.10	lasso	11	0.09	1.3e-05	5.4	5.4	7.0e-08	0.97	0.17	0.82	FALSE
6	GTEx	Artery Coronary	PPWD1	0.23	0.05	enet	17	0.15	7.0e-06	5.4	5.2	2.4e-07	0.77	0.16	0.67	FALSE
7	GTEx	Artery Tibial	PPWD1	0.16	0.18	lasso	7	0.17	2.1e-13	5.4	5.4	6.0e-08	0.97	0.15	0.85	FALSE
8	GTEx	Artery Tibial	TRIM23	0.06	0.05	enet	15	0.05	4.9e-05	5.4	5.2	1.6e-07	0.96	0.09	0.91	FALSE
9	GTEx	Artery Tibial	CTC-534A2.2	0.04	0.05	enet	4	0.01	3.1e-02	6.0	-6.0	1.6e-09	-0.91	0.03	0.87	TRUE
10	GTEx	Brain Putamen basal ganglia	PPWD1	0.14	0.16	lasso	1	0.09	3.4e-03	5.6	5.6	2.4e-08	0.97	0.09	0.78	FALSE
11	GTEx	Breast Mammary Tissue	PPWD1	0.13	0.12	lasso	6	0.10	1.0e-05	5.3	5.3	1.0e-07	0.94	0.13	0.87	FALSE
12	GTEx	Cells Transformed fibroblasts	PPWD1	0.12	0.14	lasso	2	0.13	5.7e-10	5.4	5.4	6.0e-08	0.97	0.21	0.79	FALSE
13	GTEx	Colon Sigmoid	PPWD1	0.12	0.14	enet	12	0.09	5.0e-04	5.3	5.4	7.9e-08	0.96	0.06	0.92	FALSE
14	GTEx	Colon Transverse	PPWD1	0.18	0.22	lasso	4	0.19	1.6e-09	5.4	5.5	3.7e-08	0.96	0.11	0.89	FALSE
15	GTEx	Esophagus Mucosa	PPWD1	0.11	0.08	lasso	1	0.06	5.7e-05	5.2	5.2	1.5e-07	0.96	0.15	0.85	FALSE
16	GTEx	Esophagus Muscularis	PPWD1	0.16	0.17	enet	36	0.16	4.0e-10	5.4	5.5	3.0e-08	0.88	0.24	0.76	FALSE
17	GTEx	Heart Atrial Appendage	PPWD1	0.10	0.07	lasso	1	0.04	7.6e-03	5.4	5.4	5.3e-08	0.97	0.04	0.90	FALSE
18	GTEx	Lung	PPWD1	0.06	0.11	lasso	1	0.09	1.9e-07	5.4	5.4	5.9e-08	0.97	0.26	0.74	FALSE
19	GTEx	Lung	TRIM23	0.09	0.06	lasso	3	0.05	9.2e-05	5.2	5.4	7.3e-08	0.94	0.24	0.70	FALSE
20	GTEx	Muscle Skeletal	PPWD1	0.06	0.03	enet	18	0.05	2.3e-05	6.0	5.3	8.6e-08	0.84	0.07	0.93	FALSE
21	GTEx	Nerve Tibial	PPWD1	0.28	0.37	lasso	8	0.37	5.0e-27	5.4	5.5	3.5e-08	0.96	0.26	0.74	FALSE
22	GTEx	Nerve Tibial	CTC-534A2.2	0.05	0.08	lasso	2	0.05	1.1e-04	6.0	-5.9	2.8e-09	-0.87	0.02	0.97	FALSE
23	GTEx	Prostate	CTC-534A2.2	0.21	0.02	lasso	4	0.02	1.3e-01	5.4	-5.2	2.2e-07	-0.94	0.07	0.62	FALSE
24	GTEx	Skin Not Sun Exposed Suprapubic	TRIM23	0.13	0.16	lasso	12	0.15	9.2e-09	5.3	5.4	8.4e-08	0.96	0.09	0.91	FALSE
25	GTEx	Skin Sun Exposed Lower leg	TRIM23	0.10	0.08	lasso	6	0.08	2.7e-07	5.4	5.4	6.2e-08	0.96	0.26	0.74	FALSE
26	GTEx	Stomach	PPWD1	0.09	0.09	lasso	5	0.08	1.2e-04	5.4	5.3	9.3e-08	0.96	0.11	0.83	FALSE
27	GTEx	Testis	TRIM23	0.10	0.14	lasso	8	0.13	3.0e-06	5.4	5.4	6.0e-08	0.97	0.25	0.73	FALSE
28	GTEx	Thyroid	PPWD1	0.15	0.24	lasso	7	0.24	1.5e-18	5.4	5.4	5.9e-08	0.97	0.28	0.72	FALSE
29	GTEx	Thyroid	TRIM23	0.08	0.07	lasso	4	0.04	3.2e-04	5.4	5.5	4.3e-08	0.97	0.06	0.94	FALSE
30	GTEx	Uterus	PPWD1	0.33	0.21	lasso	8	0.22	3.1e-05	5.3	5.8	5.8e-09	0.90	0.08	0.40	FALSE
31	METSIM	Adipose	CENPK	0.06	0.06	lasso	9	0.10	3.4e-15	6.0	5.3	1.4e-07	0.90	0.03	0.97	FALSE
32	METSIM	Adipose	PPWD1	0.08	0.14	enet	26	0.14	2.2e-20	5.6	5.5	4.2e-08	0.95	0.07	0.92	FALSE
33	METSIM	Adipose	TRIM23	0.06	0.08	lasso	5	0.07	7.5e-11	6.0	5.9	4.0e-09	1.00	0.02	0.98	FALSE
34	NTR	Blood	CENPK	0.04	0.08	lasso	10	0.08	1.3e-23	6.0	5.8	4.9e-09	1.00	0.02	0.98	FALSE
35	ROSMAP	Brain Pre-frontal Cortex	PPWD1	0.07	0.11	lasso	10	0.10	8.1e-13	5.5	5.4	6.6e-08	0.95	0.12	0.88	FALSE
36	ROSMAP	Brain Pre-frontal Cortex	SGTB	0.22	0.20	enet	20	0.32	1.6e-42	-3.7	5.1	2.9e-07	0.79	0.38	0.62	FALSE
37	ROSMAP	Brain Pre-frontal Cortex	CTC-534A2.2	0.07	0.06	lasso	5	0.05	1.5e-06	6.0	-5.7	1.1e-08	-0.80	0.01	0.99	FALSE
38	YFS	Blood	CENPK	0.23	0.53	bslmm	412	0.54	1.4e-214	6.0	5.6	2.2e-08	0.98	0.01	0.99	FALSE
39	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	TRIM23	0.04	0.04	blup	62	0.05	4.6e-05	5.4	5.3	1.4e-07	0.93	0.04	0.96	FALSE
40	The Cancer Genome Atlas	Breast Invasive Carcinoma	PPWD1	0.01	0.01	blup	47	0.01	1.4e-03	6.0	5.3	1.4e-07	0.88	0.02	0.76	FALSE
41	The Cancer Genome Atlas	Esophageal Carcinoma	TRIM23	0.15	0.07	lasso	2	0.08	1.2e-03	5.4	5.4	5.7e-08	0.97	0.03	0.80	FALSE
42	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C5orf44	0.02	0.03	lasso	1	0.02	4.6e-03	5.3	5.3	1.3e-07	0.94	0.02	0.82	FALSE
43	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TRIM23	0.03	0.05	blup	62	0.05	4.4e-06	5.4	5.4	6.0e-08	0.97	0.08	0.92	FALSE
44	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TRIM23	0.03	0.04	lasso	2	0.04	4.1e-05	5.4	5.5	2.9e-08	0.97	0.02	0.98	FALSE
45	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PPWD1	0.05	0.06	blup	47	0.05	7.8e-04	5.4	5.1	3.1e-07	0.93	0.02	0.91	FALSE
46	The Cancer Genome Atlas	Brain Lower Grade Glioma	PPWD1	0.06	0.12	lasso	4	0.11	1.2e-12	6.0	5.9	4.3e-09	0.98	0.01	0.99	FALSE
47	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	C5orf44	0.09	0.01	blup	57	0.02	4.2e-02	-3.1	5.3	1.1e-07	0.89	0.02	0.49	FALSE
48	The Cancer Genome Atlas	Prostate Adenocarcinoma	PPWD1	0.03	0.03	blup	47	0.04	8.1e-05	5.4	5.5	2.9e-08	0.96	0.05	0.93	FALSE