Hub : Genes

SGTB

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1200	0.0340	6.3e-10	0.070	0.093	0.093	0.091	0.092	6.4e-09	2.4e-11	2.0e-11	3.3e-11	2.5e-11
2	GTEx	Adipose Subcutaneous	0.0910	0.0390	1.7e-03	0.016	NA	0.039	NA	0.039	1.7e-02	NA	3.8e-04	NA	3.6e-04
3	GTEx	Brain Cortex	0.2570	0.0760	3.3e-05	-0.005	NA	0.065	NA	0.064	4.5e-01	NA	7.5e-03	NA	7.8e-03
4	GTEx	Cells Transformed fibroblasts	0.1500	0.0550	7.1e-04	-0.003	NA	0.018	NA	-0.003	7.6e-01	NA	1.6e-02	NA	6.0e-01
5	GTEx	Heart Left Ventricle	0.0966	0.0546	5.6e-03	0.021	NA	0.006	NA	0.028	2.7e-02	NA	1.4e-01	NA	1.2e-02
6	GTEx	Muscle Skeletal	0.0990	0.0407	4.0e-03	0.020	NA	0.026	NA	0.038	3.8e-03	NA	1.3e-03	NA	1.1e-04
7	METSIM	Adipose	0.0338	0.0161	9.5e-03	0.000	0.011	0.010	0.012	0.003	3.9e-01	6.5e-03	8.9e-03	4.7e-03	8.6e-02
8	ROSMAP	Brain Pre-frontal Cortex	0.2181	0.0372	0.0e+00	0.199	0.292	0.323	0.304	0.322	5.6e-25	6.5e-38	1.6e-42	1.3e-39	2.5e-42
9	TCGA	Breast Invasive Carcinoma	0.0663	0.0242	6.4e-09	0.040	0.045	0.046	NA	0.038	9.1e-09	1.1e-09	1.1e-09	NA	2.5e-08
10	TCGA	Kidney Renal Clear Cell Carcinoma	0.0559	0.0295	3.8e-04	0.013	0.034	0.021	NA	0.014	1.2e-02	9.4e-05	1.8e-03	NA	8.7e-03
11	TCGA	Brain Lower Grade Glioma	0.1354	0.0571	2.6e-05	0.029	0.047	0.035	NA	0.019	2.5e-04	4.5e-06	6.1e-05	NA	2.7e-03
12	TCGA	Thyroid Carcinoma	0.1060	0.0480	1.0e-05	0.024	0.051	0.040	NA	0.025	2.0e-03	1.0e-05	8.4e-05	NA	1.8e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Bipolar Disorder (2018)	1.4	2.2	10.0	2.9	-0.2	3.2	-0.2	-1.0	-0.6	0.9	2.1	-0.6	0.8	0.8	-0.5
Bipolar Disorder or Schizophrenia	1.4	3.3	11.1	3.3	0.1	3.3	1.3	-0.8	-0.7	1.2	2.9	0.4	1.4	1.9	0.1
Depressed Affect (Nagel 2018)	1.4	2.9	10.2	1.9	-0.3	1.2	-0.8	-1.0	2.1	0.1	3.2	1.2	2.5	1.2	1.9
Depression (Nagel 2018)	0.2	0.3	1.7	0.3	0.1	0.6	-0.0	-0.3	0.7	-0.5	1.3	0.2	0.7	0.5	0.5
Intelligence (Savage-Jansen 2018)	0.7	2.1	6.5	-2.0	0.4	-0.9	0.1	0.6	-1.0	-1.3	-2.5	-0.6	-2.2	-2.0	-1.1
Neuroticism (Nagel 2018)	2.9	6.8	24.4	4.1	-0.3	2.9	-0.8	-2.1	2.0	0.4	4.9	1.5	3.2	2.4	2.1
Schizophrenia (2018)	0.8	1.7	4.0	1.9	0.1	1.7	2.0	-0.2	-0.3	0.9	2.0	0.9	1.1	1.8	0.5
Schizophrenia vs Biploar Disorder	0.2	0.2	1.0	0.0	0.4	-0.4	0.6	1.0	0.5	-0.0	0.5	-0.2	0.5	-0.2	0.2
Worry (Nagel 2018)	3.7	7.9	26.9	4.9	0.1	3.6	0.1	-1.8	1.3	1.0	5.2	1.8	3.4	2.6	1.8
Alzheimer’s Disease (in mother)	0.8	0.9	2.3	-0.1	-1.1	-0.6	-1.5	0.2	1.4	-0.9	0.3	1.0	0.8	1.2	1.3
Alzheimer’s Disease (in father)	1.0	1.1	2.5	-1.5	-1.1	-1.4	-1.5	0.8	0.6	-1.6	-1.0	0.2	-0.5	-0.7	0.4
Alzheimer’s Disease (including proxy)	1.0	1.4	3.8	-0.6	-1.3	-1.0	-1.9	0.7	1.6	-1.5	-0.1	1.1	0.5	1.1	1.3
Crohns Disease (2017)	0.6	1.4	4.4	1.4	0.5	0.8	-0.2	0.5	0.6	1.1	1.6	1.4	2.1	0.5	1.6
Irritable Bowel Disease (IBD)	0.2	0.5	1.4	0.6	-0.1	0.0	-0.8	-0.6	-0.3	-0.9	0.8	0.9	1.0	0.3	1.2
Ulcerative Colitis (UC)	0.6	1.2	5.7	-0.5	-0.7	-0.6	-1.1	-1.7	-1.7	-2.4	-0.4	-0.2	-0.5	-0.1	0.1
Major Depression (MDD)	1.8	2.2	6.1	2.2	-1.2	1.7	-0.5	-1.5	0.6	0.9	2.5	1.2	1.9	0.9	1.3
Reaction Time	1.5	2.9	7.3	-2.0	2.4	-0.9	0.6	1.8	-1.8	0.5	-2.0	-1.0	-1.6	-2.7	-1.6
Verbal and Numeric Reasoning (VNR)	0.4	0.9	3.6	-1.4	0.7	-0.7	0.0	0.9	-0.1	-0.1	-1.9	-0.6	-1.4	-0.9	-0.9
Breast Cancer	0.2	0.4	1.4	-0.5	1.0	-0.8	-0.6	0.4	-1.2	0.6	-0.6	-0.6	0.0	-0.1	-0.2
Ovarian Cancer	2.5	3.3	7.4	1.8	1.4	0.7	0.3	0.8	1.8	2.3	1.9	1.8	2.5	2.7	2.1
Prostate Cancer	0.3	0.4	1.2	0.5	-1.1	1.0	0.8	-0.3	0.6	-0.3	0.9	0.4	0.5	0.2	0.6
Age at First Birth	3.1	4.6	10.6	1.6	1.6	-0.3	0.7	0.6	2.6	1.4	2.0	3.3	2.9	2.7	3.1
Bipolar Disorder (2011)	0.9	0.9	2.9	1.0	-0.7	0.9	0.9	0.3	1.7	1.0	0.9	0.4	0.9	1.1	0.5
Body Mass Index (BMI) (2010)	3.7	5.0	9.1	-2.0	-1.0	-0.6	-2.4	-1.9	-0.8	-3.0	-2.2	-2.6	-3.0	-3.0	-2.6
Coronary Artery Disease (CAD)	1.7	2.0	4.3	1.4	-2.1	0.8	-1.6	-1.6	1.2	-0.4	1.8	1.0	1.2	1.6	1.4
Crohns Disease (2012)	0.6	1.0	2.6	1.3	0.2	1.2	-0.0	0.4	0.2	1.4	1.4	1.0	1.6	0.7	1.0
Mean Putamen Volume	1.0	1.2	5.4	-1.0	2.3	-1.2	-1.0	0.5	1.3	0.3	-1.6	0.1	-0.9	-0.3	0.0
Fasting Glucose	2.5	3.0	5.5	-1.6	-1.6	0.1	-1.9	-1.4	-2.3	-1.8	-1.3	-2.3	-1.7	-1.8	-1.8
HbA1C	0.3	0.3	2.1	-0.3	1.4	-0.2	0.2	0.4	1.0	0.4	-0.3	0.3	0.5	-0.0	0.1
HDL Cholesterol	0.8	1.3	4.6	0.3	0.0	-0.6	0.7	0.5	0.5	0.6	0.9	1.1	1.9	2.1	1.8
LDL Cholesterol	0.4	0.7	2.2	-1.5	-1.0	-1.0	-0.6	-0.3	0.6	-0.4	-0.7	-0.4	-0.9	-1.3	-0.4
Lupus	0.1	0.2	0.5	-0.5	-0.2	-0.6	0.2	0.4	0.7	-0.4	0.0	0.3	0.5	-0.1	0.6
Neuroticism (2016)	0.6	0.9	3.2	1.2	0.4	1.8	0.2	-1.6	-0.3	0.2	1.7	-0.5	0.4	-0.1	-0.1
Primary Biliary Cirrhosis	0.6	0.9	2.5	1.2	-1.6	0.8	-0.3	0.0	0.8	-0.0	1.4	0.7	1.2	0.7	1.1
Rheumatoid Arthritis	0.9	1.3	3.9	-1.8	0.5	-2.0	-0.9	0.6	0.1	-1.7	-1.6	0.4	-0.1	0.0	0.9
Schizophrenia (2014)	1.2	2.7	5.5	1.7	1.3	0.7	2.0	1.0	0.5	1.4	1.8	2.1	1.9	2.3	1.6
Triglycerides	1.1	1.8	6.4	0.4	-0.2	1.4	-0.7	-1.2	-1.4	0.4	0.2	-1.8	-1.3	-2.5	-2.0
Type 2 Diabetes (T2D) (2012)	0.3	0.4	2.6	0.2	0.1	-0.2	0.2	-0.1	1.6	-0.0	0.0	0.8	0.5	0.3	0.9
Ulcerative Colitis	0.9	1.3	3.1	-0.1	-1.3	0.0	-1.6	-1.5	-1.6	-1.8	-0.6	-0.7	-1.2	0.0	-0.8
Blood Eosinophil Count	0.2	1.2	3.4	-1.7	-0.4	-1.8	0.1	1.0	-0.7	-0.0	-1.8	-0.2	-1.3	-1.1	-0.6
Blood Platelet Count	0.2	2.6	6.9	-0.9	1.8	-2.4	0.1	2.0	2.6	-0.3	-1.0	2.3	1.0	0.6	1.8
Blood Red Count	0.3	2.5	8.0	2.5	-1.4	2.8	-1.3	-1.9	0.2	0.8	2.1	-1.3	0.4	-0.6	-1.0
Blood White Count	0.2	1.7	4.9	-0.4	-1.2	0.8	-2.2	-1.1	-1.8	-0.3	-0.1	-1.5	-1.3	-1.8	-1.5
Heel T-Score	0.4	3.5	12.1	-1.7	-0.2	-1.6	-1.1	0.1	-0.3	-1.9	-3.5	-1.1	-3.2	-2.2	-1.7
BMI	0.8	4.6	15.1	-0.7	-1.2	0.7	-2.7	-2.4	-1.5	-3.9	-0.9	-2.5	-2.3	-2.4	-2.0
Height	0.7	12.6	42.2	3.6	0.2	0.8	3.0	3.3	3.7	6.5	2.5	4.4	3.7	3.5	3.3
Waist Hip Ratio (WHR)	0.8	3.8	18.3	1.0	-0.2	0.3	-0.2	2.3	0.3	4.3	1.8	1.7	2.1	2.5	2.0
Systolic Blood Pressure	0.5	2.5	6.7	0.5	-0.1	1.4	-1.7	-1.3	-2.1	0.4	-0.3	-2.6	-1.8	-1.4	-2.6
Smoking Status	0.3	0.7	2.9	1.5	-0.4	1.7	-0.4	-0.2	-0.4	0.6	1.0	-0.3	-0.3	-0.4	-0.8
Allergy or Eczema	0.2	0.4	1.9	0.4	0.5	0.7	1.4	-0.3	-0.1	0.8	0.8	0.2	0.8	0.2	0.2
Cardiovascular Disease	0.9	2.9	7.4	1.7	-0.2	2.7	-0.4	-2.0	-2.3	0.8	1.3	-2.4	-0.4	-1.6	-2.0
Hypothyroidism (self reported)	0.7	1.5	5.8	1.4	1.9	1.4	0.4	1.1	0.3	2.4	0.2	-0.7	-0.1	-0.8	-1.5
Respiratory disease	0.2	0.4	2.8	0.6	-0.4	0.6	-1.7	-0.2	0.4	0.1	0.6	-0.1	-0.0	0.3	-0.3
Type 2 Diabetes (T2D) (2018)	0.8	1.5	4.7	2.1	-0.3	2.2	-1.6	0.1	0.1	1.3	1.9	0.6	0.7	0.2	0.4
Lung FEV1/FVC ratio	0.3	1.4	4.6	-0.5	-2.0	0.0	-0.8	-2.1	-1.7	-1.9	-0.2	-0.5	-0.6	0.2	0.4
Lung FVC	0.7	3.5	8.0	-1.4	1.3	-2.6	1.5	2.8	2.5	1.7	-2.6	0.9	-1.4	-1.8	-0.3
Neuroticism	2.3	5.6	18.2	3.4	0.2	2.3	-0.2	-1.3	1.8	0.3	4.3	2.0	3.3	2.4	2.7
Chronotype (morning person)	0.9	2.0	9.4	-1.1	1.9	-1.7	1.1	3.1	0.8	1.1	-1.3	1.1	0.5	-0.0	0.6
Hair Pigment	0.0	0.7	2.1	1.2	0.6	1.3	-0.7	0.5	0.0	1.5	1.1	0.2	0.7	0.8	0.2
Tanning	0.0	0.2	0.8	-0.3	0.6	-0.4	0.2	0.2	0.9	0.3	-0.4	0.4	-0.0	0.1	0.1
Hand grip strength (left)	1.5	4.0	9.1	-0.9	-2.2	0.1	-2.1	-1.9	-1.0	-2.7	-1.0	-2.4	-2.4	-3.0	-2.2
Number of treatments/medications taken	0.5	0.8	2.3	1.5	-0.1	1.4	-0.6	-0.9	-0.7	-0.0	1.5	0.9	0.7	0.3	0.4
Average weekly spirits intake	0.6	0.7	3.4	0.8	-1.8	1.1	-1.3	-0.7	0.4	0.2	0.8	0.3	-0.2	-0.2	0.1
Sensitivity / hurt feelings	1.0	1.8	5.5	1.8	1.0	1.2	0.8	-1.1	0.0	0.1	2.4	0.9	1.6	1.9	1.0
Frequency of depressed mood in last 2 weeks	0.6	0.8	3.3	0.8	0.6	0.9	-0.4	-0.7	1.1	-0.3	1.8	0.4	0.8	1.0	0.7
Hearing difficulty/problems: Yes	0.4	0.5	1.6	-0.7	0.6	-0.4	-0.4	0.4	-0.4	0.1	-0.9	-1.0	-1.3	-0.3	-1.1
Relative age of first facial hair	0.4	0.8	4.6	-1.5	0.8	-0.8	2.1	0.2	-0.5	-0.6	-0.2	-0.1	0.4	-0.3	0.5
Other serious medical condition/disability diagnosed by doctor	1.4	1.8	5.0	1.7	-2.2	1.4	-1.9	-2.0	-0.7	-0.9	1.4	-0.3	-0.3	0.0	-0.5
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.2	-0.3	-1.0	0.4	-0.2	0.3	-0.6	-0.1	-0.4	-0.9	-1.1	-0.3	-0.9
Ever had hysterectomy (womb removed)	0.5	0.6	2.2	-1.0	-1.5	-0.4	-0.3	-0.3	-0.8	-1.4	-0.4	-0.3	-0.4	-0.4	-0.0
Systolic blood pressure, automated reading	0.6	1.8	5.4	-0.3	-0.3	0.7	-1.4	-1.0	-1.4	-0.7	-0.9	-2.3	-1.6	-1.4	-2.1
Eye problems/disorders: Diabetes related eye disease	0.2	0.3	0.7	0.7	0.4	0.2	0.6	0.2	0.8	0.1	0.8	0.7	0.5	-0.0	0.4
Angina	1.2	1.5	5.1	2.3	-1.5	1.9	-0.5	-0.1	0.5	1.2	1.8	0.9	0.8	0.5	0.4
Medication for hormone replacement therapy	1.1	1.3	5.4	-0.4	1.2	-0.8	2.3	2.1	0.2	1.3	-0.6	0.6	0.3	0.3	0.4
Vitamin and mineral supplements	0.4	0.5	1.7	0.2	0.6	1.0	0.3	0.0	-0.8	0.5	0.4	-1.3	-0.0	-1.2	-0.8
Supplements: Zinc	0.6	0.6	5.4	-1.0	-0.2	-0.7	2.3	0.2	0.2	0.5	0.0	0.3	0.6	-0.2	0.4
Medication: Co-codamol	0.7	0.8	3.3	1.6	0.2	1.1	-0.4	-0.4	0.4	0.2	1.8	0.5	0.5	1.0	0.2
Medication: Metformin	0.3	0.5	2.0	0.5	-0.6	0.5	-1.4	0.6	0.9	0.1	0.7	0.7	0.4	-0.1	0.9
Diabetes (father)	0.7	0.8	3.3	0.3	1.7	-0.3	1.8	0.8	0.3	0.5	0.4	0.4	1.1	0.9	0.5
Diabetes (mother)	0.3	0.4	1.2	-1.1	-0.1	-0.7	-0.2	0.3	0.6	-0.4	-1.0	-0.7	-0.7	0.2	-0.6
Severe depression (siblings)	0.5	0.6	1.9	1.3	-0.8	1.4	-1.1	-0.4	-0.2	-0.4	0.7	-0.5	-0.2	-0.0	-0.6
Pack years adult smoking proportion	0.3	0.5	2.2	0.4	-1.0	0.7	-1.5	-0.6	0.6	-0.3	0.9	0.0	0.1	-0.4	0.4
Impedance of leg (right)	1.2	5.7	30.5	1.8	3.0	0.6	2.9	2.7	0.9	5.5	0.8	1.5	1.6	1.9	0.4
Leg fat-free mass (left)	0.2	1.2	4.8	0.2	-2.2	0.3	-2.2	-0.9	-0.1	-1.7	-0.1	-0.4	-0.4	-0.7	0.2
Trunk fat percentage	0.5	2.2	9.4	1.8	0.9	0.9	0.5	1.4	1.4	3.1	1.1	1.2	1.5	1.4	1.0
Hand grip strength (right)	1.2	3.3	7.9	-0.6	-2.3	0.4	-1.7	-1.9	-0.7	-2.2	-0.8	-2.1	-2.2	-2.8	-2.0
Townsend deprivation index at recruitment	0.5	0.8	2.5	0.9	0.5	-0.1	-0.0	0.5	0.7	0.2	0.8	1.6	0.8	1.4	1.1
Current tobacco smoking	0.4	0.6	1.3	1.0	0.5	1.2	-1.1	0.8	1.0	0.7	1.0	0.4	0.6	-0.3	0.3
Average weekly fortified wine intake	1.5	1.7	3.7	1.9	-0.5	0.8	1.6	-1.5	-1.1	0.9	1.9	0.1	1.7	1.5	0.5
Maternal smoking around birth	0.4	0.6	2.2	1.5	-0.8	1.0	-0.9	-0.4	-0.0	0.6	1.1	-0.4	-0.2	0.4	-0.7
Fed-up feelings	0.7	1.3	4.1	0.2	0.1	-0.7	-0.5	-0.4	1.8	-0.5	1.1	1.7	1.2	1.2	2.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.0	0.1	1.0	0.0	0.5	0.5	0.4	0.5	1.0	0.6	0.7	0.7	0.7
Relative age voice broke	0.5	0.8	2.9	-0.5	1.6	-0.6	1.7	1.3	0.9	0.2	0.5	0.2	1.0	0.2	0.4
Taking other prescription medications	0.3	0.5	2.5	0.9	-0.0	0.8	-1.6	-0.6	-0.3	-0.1	0.6	-0.2	-0.3	0.8	-0.5
Age when periods started (menarche)	0.4	1.0	8.1	-0.4	1.1	0.1	2.9	0.9	0.6	0.7	0.3	0.7	0.5	0.4	0.2
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	1.2	-0.3	-1.1	-0.4	-0.1	1.0	0.3	-0.4	-0.0	0.9	0.3	0.7	0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	4.9	0.3	0.1	-0.2	2.2	0.7	0.1	0.3	-0.0	0.9	0.7	0.5	0.9
Tinnitus: Yes, but not now, but have in the past	0.5	0.6	2.4	-0.8	-0.0	-1.1	-1.5	0.7	-0.9	-0.3	-0.8	0.3	-0.5	-0.2	0.0
Qualifications: CSEs or equivalent	0.6	0.8	1.8	-0.8	-0.8	-1.0	-0.3	-0.5	0.5	-1.3	-0.9	-0.8	-1.2	-1.2	-1.0
Serious illness, injury or assault to yourself	1.2	1.4	3.9	0.3	-0.6	-0.2	0.3	1.0	1.0	-0.3	1.1	1.8	1.7	2.0	1.9
High blood pressure	1.0	2.7	6.5	1.2	-1.5	2.5	-1.2	-2.2	-2.4	-0.3	1.4	-2.0	-0.6	-1.2	-1.5
Hayfever, allergic rhinitis or eczema	0.2	0.5	1.7	0.8	0.4	1.3	1.1	-1.0	-0.1	0.5	0.8	-0.4	0.1	-0.4	-0.5
Multivitamins +/- minerals	0.3	0.3	0.9	0.2	1.0	-0.7	0.9	0.3	0.5	0.3	-0.5	0.8	-0.3	0.6	-0.0
Stomach or abdominal pain in last month	0.8	1.0	3.3	0.9	-1.3	0.4	-1.2	-1.8	0.0	-1.6	0.7	0.1	0.6	0.4	0.7
Supplements: Glucosamine	0.5	0.7	1.9	1.1	0.5	0.4	-0.1	-0.5	-0.0	-0.2	1.3	0.5	1.4	1.3	1.0
Diverticular disease/diverticulitis (self-reported)	5.1	6.1	13.1	1.4	-2.1	2.8	-2.7	-3.6	-2.1	-1.4	0.0	-2.9	-2.6	-2.6	-3.2
Medication: Atenolol	1.3	1.7	4.7	1.0	0.0	1.9	-0.6	-2.2	-1.4	-1.0	0.9	-1.5	-0.8	-1.3	-1.4
Medication: Levothyroxine sodium	0.6	1.1	3.8	2.0	0.7	1.6	-0.1	-0.3	-0.1	1.6	1.5	0.1	1.2	0.1	0.0
Sitting height	0.1	0.8	3.5	1.3	-0.8	0.9	0.8	0.6	-0.0	1.9	1.0	0.3	0.8	0.5	0.3
Chronic bronchitis/emphysema (father)	1.5	1.7	7.0	1.7	-0.6	2.0	0.2	-2.7	-0.4	-0.2	2.0	-0.9	-0.0	-0.6	-0.8
High blood pressure (mother)	1.0	1.4	8.1	1.4	0.2	2.8	0.2	-0.9	-0.5	0.2	1.3	-1.0	-0.7	-0.9	-1.4
Body mass index (BMI)	0.4	1.9	6.6	0.1	-1.3	0.8	-2.6	-1.4	-0.5	-2.2	-0.2	-1.4	-1.2	-1.2	-1.0
Impedance of leg (left)	1.6	7.8	40.2	1.9	3.7	0.7	3.7	2.9	0.9	6.3	1.2	1.5	2.1	2.1	0.6
Leg predicted mass (left)	0.2	1.3	5.2	0.1	-2.3	0.2	-2.3	-1.0	-0.2	-1.8	-0.2	-0.5	-0.5	-0.7	0.1
Trunk fat mass	0.2	1.1	4.0	1.4	-0.1	0.7	-0.4	0.9	1.1	2.0	0.7	0.8	1.0	0.9	0.9
Waist circumference	0.2	0.7	2.8	1.0	-1.3	0.8	-1.7	0.1	0.5	0.2	0.8	0.2	0.6	0.5	0.7
Number of incorrect matches in round	0.1	0.2	0.9	0.2	-0.2	-0.1	0.0	-0.0	0.7	-0.3	0.4	0.9	0.1	0.7	0.5
Past tobacco smoking	1.1	2.1	5.7	0.0	1.6	-0.9	0.8	1.2	1.7	0.5	0.5	1.7	2.3	1.4	2.4
Alcohol usually taken with meals	0.7	1.2	3.1	0.4	-1.6	0.6	1.0	-0.7	0.3	-0.5	1.4	1.3	1.6	0.7	1.8
Nervous feelings	0.9	1.7	5.6	2.4	0.1	2.2	-0.4	-1.7	-0.0	0.3	2.3	-0.4	0.4	0.5	-0.7
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.0	3.9	0.7	0.2	1.0	0.7	-1.8	0.1	-0.8	2.0	0.2	0.9	1.2	0.4
Hearing difficulty/problems with background noise	0.3	0.5	1.3	0.3	0.4	0.1	1.0	-0.2	0.6	0.1	0.9	1.0	0.5	1.2	0.8
Hair/balding pattern: Pattern 2	0.5	0.6	1.5	0.8	0.6	0.9	1.1	-0.3	-1.2	0.2	0.6	-1.1	0.0	0.4	-1.1
Had menopause	0.6	0.8	3.1	0.2	-1.8	0.7	-1.2	-1.0	-0.8	-1.0	0.1	-1.1	-0.4	-0.0	-0.6
Had other major operations	1.2	1.4	3.9	0.0	-0.4	0.9	-1.3	-2.0	-1.6	-1.3	0.2	-1.4	-1.0	-1.0	-1.5
Forced vital capacity (FVC)	0.5	1.7	6.0	-0.4	1.0	-1.0	1.3	1.7	0.7	2.4	-1.6	0.2	-1.1	-1.8	-0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	2.6	-0.1	0.4	0.2	1.6	0.2	-1.1	0.3	-0.9	-0.2	-0.6	-0.3	-0.4
Ever unenthusiastic/disinterested for a whole week	1.7	2.1	6.1	1.8	0.6	1.3	0.6	-0.2	1.7	1.1	2.5	0.9	2.0	1.4	1.4
Qualifications: None of the above	0.1	0.3	1.1	0.2	-0.0	0.5	-1.1	-0.5	-1.0	-0.6	0.0	-0.5	-0.5	-0.3	-0.4
Financial difficulties in last 2 years	0.7	0.9	4.6	0.5	0.9	0.4	2.1	-0.0	-0.0	1.2	1.0	0.9	1.1	0.2	0.8
Mouth/teeth dental problems	0.3	0.5	1.0	-0.6	0.0	0.4	0.7	-1.0	-0.4	-0.5	-0.3	-1.0	-0.7	-0.7	-1.0
Heart attack	0.9	1.1	3.8	1.1	-0.7	1.2	-1.2	-1.2	0.1	-0.5	2.0	0.7	1.2	0.9	0.8
Allergy	0.4	0.9	2.5	-1.1	0.1	-1.6	0.2	1.2	0.7	-0.6	-0.7	0.7	0.8	1.0	1.4
Pain all over the body in last month	0.5	0.5	1.4	0.2	1.0	-0.3	-1.0	1.2	0.7	0.6	0.1	1.1	0.4	0.5	0.7
Diabetes (self-reported)	0.6	0.9	6.5	0.5	-0.7	1.0	-2.5	-0.5	0.4	-0.3	0.4	-0.1	-0.7	-1.0	-0.3
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	2.6	0.6	0.4	0.5	1.0	0.6	1.6	1.5	0.6	0.9	0.7	0.3	0.7
Medication: Ramipril	1.3	1.7	5.6	2.1	0.1	2.4	-0.2	-1.0	-0.5	0.4	2.4	0.2	1.6	0.9	0.5
Medication: Simvastatin	0.3	0.4	1.6	1.3	-0.5	0.8	-0.8	-0.5	-0.8	0.1	0.6	0.5	-0.0	0.1	0.2
Fluid intelligence score	0.4	0.7	2.6	-0.9	0.8	-0.3	0.4	0.8	0.3	0.0	-1.6	-0.5	-1.3	-0.6	-1.2
Illnesses of siblings	4.8	6.8	14.5	1.7	1.8	-0.0	2.7	0.5	1.8	2.1	2.7	3.7	3.8	3.2	3.7
Neuroticism score	1.6	3.4	11.4	2.5	0.1	1.4	-0.6	-1.5	1.4	-0.1	3.4	1.7	2.5	1.7	2.2
Weight	0.2	0.8	4.0	1.0	-1.6	0.9	-2.0	-0.4	0.2	-0.4	0.5	-0.2	-0.0	-0.2	0.2
Impedance of arm (right)	2.6	12.1	49.7	1.2	2.9	-1.1	4.2	4.6	2.9	7.0	0.7	3.8	3.0	2.7	2.7
Arm fat percentage (right)	0.1	0.3	1.1	0.4	0.1	-0.0	-0.5	1.0	1.0	0.8	-0.2	0.5	0.3	0.1	0.4
Trunk fat-free mass	0.4	2.3	7.2	-0.2	-2.6	0.3	-2.7	-1.3	-0.8	-2.6	-0.5	-1.0	-1.2	-1.0	-0.5
Hip circumference	0.1	0.4	2.2	0.5	-0.7	0.1	-0.6	0.4	1.5	-0.9	-0.1	0.3	0.4	0.1	0.5
Time employed in main current job	0.2	0.2	0.9	0.1	-0.4	0.0	-1.0	-0.6	0.4	-0.8	0.3	0.1	0.1	-0.2	0.2
Alcohol intake versus 10 years previously	0.8	1.2	3.8	-1.0	-0.1	-0.2	-1.4	0.2	-0.9	-0.6	-1.4	-1.1	-2.0	-1.1	-1.3
Father’s age at death	0.9	1.2	2.9	1.0	-0.8	0.5	0.8	-0.9	0.9	0.6	1.7	0.9	1.5	1.4	1.4
Worrier / anxious feelings	1.5	2.8	8.6	2.3	-1.6	1.6	-1.2	-2.1	0.6	-0.9	2.9	0.8	1.7	1.4	1.4
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	1.0	0.3	1.0	0.2	-0.5	-0.5	0.8	-0.5	0.8	0.3	-0.0	-0.2	0.1
Falls in the last year	0.4	0.5	2.8	-0.2	1.7	-0.6	-0.5	0.4	0.6	0.1	0.4	0.9	0.6	0.2	0.8
Hair/balding pattern: Pattern 3	0.4	0.5	2.1	-0.7	-0.5	-0.5	-1.4	-0.1	-0.1	-1.5	-0.3	0.5	-0.1	-0.7	0.7
Number of live births	1.0	1.3	3.0	1.2	0.5	1.3	0.9	-0.6	-1.1	0.7	1.7	0.6	1.7	1.5	1.1
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	2.4	-0.5	0.4	-1.0	1.5	1.1	0.4	1.5	-1.3	0.3	-0.7	-1.4	-0.3
Pulse rate	1.4	2.3	7.3	-0.4	-2.7	0.8	-2.5	-1.9	-0.1	-1.6	-0.0	-1.5	-1.1	-1.4	-1.1
Happiness	2.0	2.5	6.7	-2.6	0.8	-1.9	-0.9	0.7	0.9	-1.6	-2.4	-1.2	-2.0	-1.2	-1.1
Noisy workplace	0.3	0.4	1.1	-0.7	0.7	-0.5	-0.9	-0.3	-1.1	-0.6	-0.5	-0.3	-0.1	-0.4	-0.1
Qualifications: A levels/AS levels or equivalent	0.3	0.6	2.2	0.6	0.3	0.1	0.9	0.1	-0.2	0.8	0.8	0.7	1.5	0.7	1.0
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.5	3.3	-0.0	0.9	-0.3	-0.1	0.8	1.8	0.3	-0.0	0.8	0.3	-0.7	0.5
Mouth/teeth dental problems: Dentures	0.2	0.4	1.3	-0.3	0.2	-0.8	-1.1	0.7	0.3	-0.8	-0.9	0.2	-0.3	0.0	0.3
Asthma	0.1	0.2	0.9	0.2	0.8	-0.0	-0.4	-0.0	-0.2	1.0	0.2	-0.0	-0.2	0.7	-0.4
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.3	0.7	-0.1	-0.6	-0.1	0.8	-0.2	0.7	0.7	0.5	0.8	0.5	-0.2	0.9
Medication: Cholesterol lowering	0.3	0.4	1.4	1.2	-0.2	0.6	-0.9	0.0	0.5	0.3	0.9	0.6	0.6	-0.3	0.4
Depression (self-reported)	1.8	2.2	7.4	1.7	2.7	1.1	1.3	0.1	1.0	2.0	2.0	0.8	1.6	1.0	0.5
Medication: Lansoprazole	0.4	0.5	1.7	0.8	-0.1	0.8	-1.3	-0.4	-0.8	0.1	1.0	-0.7	0.3	-0.1	-0.4
Prospective memory result	2.3	2.9	7.2	1.4	1.1	0.5	0.5	1.0	0.8	0.9	2.2	2.2	2.6	2.7	2.1
Lung cancer (father)	1.3	1.5	4.0	-1.2	-0.4	-0.7	-2.0	-0.6	-0.2	-2.0	-1.2	-1.2	-1.5	-1.2	-1.1
Illnesses of mother	0.2	0.3	1.3	-0.7	0.0	-1.1	0.7	0.1	-0.5	0.6	-0.5	-0.0	0.3	0.0	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.2	3.1	-1.1	0.4	-1.7	1.0	1.4	1.1	0.8	-1.8	0.6	-0.9	-1.3	-0.0
Pulse wave Arterial Stiffness index	0.9	1.1	2.0	-1.4	-0.9	-0.1	-0.9	-1.1	-0.4	-1.2	-0.6	-1.0	-1.3	-1.4	-1.1
Impedance of arm (left)	2.8	12.8	48.2	1.5	3.3	-0.8	4.7	4.4	3.0	6.9	0.9	3.7	3.1	3.1	2.6
Arm fat mass (right)	0.1	0.3	1.8	0.8	-0.6	0.6	-1.3	0.1	0.7	0.0	0.1	-0.0	0.2	-0.1	0.2
Trunk predicted mass	0.4	2.3	6.9	-0.2	-2.6	0.3	-2.6	-1.4	-0.9	-2.6	-0.5	-1.0	-1.1	-1.1	-0.4
Standing height	0.5	4.8	17.8	2.3	-0.6	0.6	1.2	2.0	1.7	4.2	1.7	2.4	2.4	2.3	2.2
Length of working week for main job	0.3	0.3	1.1	1.0	-0.2	0.1	-0.2	0.7	0.8	-0.7	0.2	0.6	0.5	0.2	0.6
Exposure to tobacco smoke at home	1.3	1.5	5.1	0.2	0.3	0.5	0.3	-0.2	-1.3	0.6	-1.0	-1.5	-2.1	-1.6	-2.3
Breastfed as a baby	1.4	1.7	5.0	-0.9	0.3	-1.4	0.3	1.1	0.6	-0.7	0.3	1.0	2.2	2.2	2.2
Tense / ‘highly strung’	4.8	8.0	26.3	3.9	-1.1	2.7	-0.8	-2.8	-0.1	0.4	5.1	1.9	3.6	3.7	2.6
Seen doctor (GP) for nerves, anxiety, tension or depression	3.2	4.8	16.5	3.0	0.5	1.9	0.4	-1.3	0.8	0.8	4.1	1.8	3.2	2.7	2.2
Hair/balding pattern: Pattern 4	0.1	0.2	0.6	0.6	-0.8	0.4	0.3	0.1	-0.4	0.5	-0.2	-0.2	-0.6	0.0	-0.6
Birth weight of first child	0.2	0.4	1.7	0.1	-1.3	-0.6	-0.1	-0.4	1.1	-0.5	0.2	0.7	0.0	0.3	0.7
Peak expiratory flow (PEF)	0.2	0.4	1.5	-0.4	-0.6	-0.0	1.2	-0.3	-0.4	0.6	-0.7	-0.3	-0.7	-1.2	-0.3
Pulse wave reflection index	0.7	0.9	2.0	-1.2	0.0	-0.5	-0.9	-0.7	-0.7	-1.1	-0.9	-0.7	-1.4	-1.2	-1.2
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.3	0.9	-0.3	0.2	-0.1	0.6	1.0	0.5	0.8	1.0	1.0	1.0	1.1
Loud music exposure frequency	1.4	1.5	4.1	1.0	2.0	0.5	0.1	1.8	1.9	1.6	0.2	1.3	0.8	0.3	0.8
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.7	0.5	-0.6	-0.1	0.1	-1.1	-0.5	-0.1	1.0	0.7	1.3	0.9	1.0
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.4	0.4	0.3	-0.2	0.0	0.6	-0.1	0.2	0.3	0.2	-0.1	-0.1	-0.2
Blood clot in the leg (DVT)	0.2	0.3	1.0	0.5	1.0	0.4	-0.7	-0.0	-0.7	0.4	-0.1	0.2	-0.7	0.2	-0.6
Medication: Paracetamol	0.2	0.4	2.1	0.2	-0.7	0.7	-0.6	-0.7	-0.0	-1.4	0.5	0.4	-0.5	-0.4	0.0
Headache pain in last month	0.7	1.2	3.6	1.1	-0.4	1.1	0.3	-1.5	-0.5	-1.9	1.5	0.4	1.0	1.0	0.6
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	1.0	-0.5	0.0	-0.5	1.0	0.4	0.5	-0.4	-0.5	-0.1	0.1	0.8	0.1
Glaucoma (self-reported)	1.3	1.6	3.1	-1.8	-0.5	-1.5	-1.8	-1.3	-0.4	-1.6	-1.4	-0.8	-1.5	-0.5	-0.6
Gout (self-reported)	0.1	0.2	0.5	-0.7	0.2	-0.3	0.2	0.6	-0.2	-0.1	-0.4	0.4	0.1	-0.2	0.6
Hypothyroidism/myxoedema (self-reported)	0.6	1.1	4.2	1.5	1.4	1.5	0.5	0.5	0.1	2.1	0.6	-0.4	0.1	-0.7	-1.0
Medication: Amlodipine	0.5	0.7	1.9	-0.9	-0.7	-0.6	-1.2	0.1	-0.5	-1.4	-0.4	0.9	0.5	0.6	1.4
Medication: Ventolin 100micrograms inhaler	1.0	1.3	5.9	-0.5	-0.5	0.3	-2.4	-1.7	0.2	-0.1	-0.3	-1.3	-1.2	-1.2	-1.2
Birth weight	2.2	4.7	13.2	-2.4	-0.9	-0.9	-0.7	-0.5	-1.2	-1.5	-3.0	-2.3	-3.6	-3.1	-2.7
Chronic bronchitis/emphysema (mother)	0.1	0.2	0.5	0.7	0.3	0.4	0.1	0.1	0.2	0.4	0.5	0.5	0.5	0.3	0.2
High blood pressure (siblings)	1.7	2.5	7.5	-0.1	-0.8	0.6	-2.7	-0.6	-1.4	-1.6	-1.0	-2.2	-2.0	-1.5	-2.2
Forced vital capacity (FVC), Best measure	0.6	2.1	5.8	-0.7	1.3	-1.7	1.1	2.4	1.8	1.9	-1.8	0.9	-0.8	-1.3	-0.2
Body fat percentage	0.3	1.2	5.5	1.6	0.8	0.9	-0.0	1.0	0.8	2.3	0.7	0.7	1.0	0.9	0.5
Leg fat percentage (right)	0.1	0.5	2.6	1.2	0.0	1.1	-1.6	-0.1	-0.2	0.3	0.4	-0.3	0.0	0.2	-0.2
Arm fat-free mass (right)	0.5	2.7	7.7	0.2	-2.6	0.9	-2.6	-2.0	-1.2	-2.8	0.0	-1.5	-1.0	-1.1	-0.7
Exposure to tobacco smoke outside home	0.7	0.9	3.5	-0.5	-1.9	-0.5	-1.5	-0.5	0.4	-1.3	0.4	0.7	-0.4	-1.0	0.8
Comparative body size at age 10	2.8	7.7	24.5	-4.0	-1.2	-2.3	-3.1	-0.4	-1.3	-4.9	-3.4	-1.7	-3.0	-2.9	-1.1
Number of full brothers	0.1	0.2	0.6	0.1	0.2	0.0	0.5	0.8	0.4	0.8	0.0	0.0	0.1	0.4	-0.1
Worry too long after embarrassment	0.3	0.5	1.6	-0.0	-1.0	0.2	-0.9	-1.3	-0.3	-1.0	-0.1	-0.4	-0.9	-0.6	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	6.4	8.2	24.6	4.3	0.7	3.3	1.4	-1.1	1.2	3.8	5.0	1.6	3.3	3.1	1.6
Wheeze or whistling in the chest in last year	0.9	1.6	3.1	0.8	-0.4	1.3	-1.8	-1.5	-1.0	0.1	0.7	-1.7	-0.9	-1.7	-1.7
Number of children fathered	0.6	0.6	1.5	0.3	0.9	-0.4	0.3	1.2	1.0	0.4	-0.0	1.1	0.8	1.0	0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.4	1.8	0.2	-0.2	0.8	1.3	-1.0	-0.4	-0.0	0.2	-0.8	-0.4	0.1	-1.0
Age at first live birth	0.7	1.2	3.2	1.8	-0.9	1.2	-0.2	-0.6	1.2	0.7	1.8	0.8	1.2	0.9	0.7
Pulse wave peak to peak time	1.0	1.2	2.2	1.4	0.8	0.2	1.0	1.3	0.4	1.4	0.6	1.0	1.3	1.5	1.1
Health satisfaction	1.1	1.4	7.2	0.0	-1.6	0.3	-2.7	-1.0	0.8	-2.3	0.6	-0.0	-0.1	-0.3	0.4
Shortness of breath walking on level ground	0.4	0.5	1.4	0.5	-0.6	0.2	-1.2	0.1	0.3	0.3	1.1	0.8	1.0	0.3	1.2
Qualifications: College or University degree	1.0	3.1	6.1	-2.2	-1.0	-1.0	0.1	-0.8	-2.0	-1.4	-2.5	-2.1	-2.4	-1.8	-2.2
Eye problems/disorders: None of the above	0.5	0.6	2.4	0.1	0.8	0.1	1.5	0.8	-0.7	1.5	-0.4	-0.4	0.1	-0.2	-0.7
Mouth/teeth dental problems: Loose teeth	0.7	0.8	2.2	1.1	-0.7	1.2	-1.5	-0.6	-0.7	-0.8	1.4	-0.0	0.5	0.4	0.3
Emphysema/chronic bronchitis	1.8	2.1	5.2	0.9	-1.5	1.3	-2.3	-2.2	-1.4	-0.7	0.4	-1.5	-1.1	-1.3	-1.6
Medication for pain relief, constipation, heartburn	0.6	1.0	4.9	-0.3	2.2	-0.3	1.2	1.2	0.7	1.5	-0.6	-0.8	0.3	0.2	-0.7
Neck or shoulder pain in last month	0.4	0.5	2.5	-0.3	1.6	-0.4	-0.1	1.1	-0.4	-0.0	0.1	0.7	0.8	0.7	0.7
Medication: Blood pressure	0.6	1.1	3.6	1.4	-0.8	1.7	-0.9	-1.4	-0.5	0.6	1.9	0.2	0.7	-0.2	0.2
Angina (self-reported)	1.4	1.8	5.8	2.4	-1.4	2.0	-0.2	0.1	0.5	1.6	2.0	1.1	1.0	0.8	0.5
Migraine (self-reported)	2.4	2.9	9.7	1.5	1.8	0.9	3.1	0.7	0.9	1.8	1.8	0.8	2.5	2.0	0.7
Medication: Ibuprofen	0.3	0.4	1.3	-0.5	-0.8	-0.6	0.5	0.4	1.1	0.4	0.1	0.8	0.4	-0.2	0.8
Medication: Allopurinol	1.6	2.2	5.2	-0.1	2.3	-0.8	1.2	2.1	0.6	1.4	-0.1	2.2	1.5	1.3	1.9
Medication: Omeprazole	1.1	1.3	5.3	1.6	-0.3	0.6	0.0	0.7	0.1	0.6	1.4	1.1	1.6	2.3	1.2
Medication: Seretide 50 evohaler	0.3	0.4	1.1	0.5	-1.0	0.5	-0.2	-0.1	0.6	1.0	0.7	0.2	0.5	0.6	0.1
Mean time to correctly identify matches	1.0	1.9	4.8	-1.6	2.2	-0.9	1.4	1.9	-1.2	1.2	-1.3	-0.1	-0.7	-1.8	-0.7
Heart disease (mother)	0.4	0.5	2.0	0.8	0.8	0.9	-1.4	-0.8	-0.2	-0.8	0.3	-0.2	-0.4	0.5	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	1.0	2.0	0.2	-1.4	0.8	-0.6	-1.4	-1.4	-1.0	0.0	-1.3	-1.0	-0.5	-1.2
Whole body fat mass	0.1	0.4	1.5	1.1	-0.1	0.7	-0.9	0.5	0.6	1.2	0.4	0.3	0.4	0.4	0.3
Leg fat mass (right)	0.1	0.4	2.2	1.1	-0.3	1.0	-1.5	-0.2	0.1	0.1	0.4	-0.2	0.2	0.0	0.0
Arm predicted mass (right)	0.6	2.9	7.3	0.4	-2.5	1.1	-2.7	-2.2	-1.6	-2.7	0.1	-1.6	-1.0	-1.1	-0.8
Pulse rate, automated reading	2.3	7.3	16.2	-1.1	-1.8	1.1	-2.8	-3.4	-3.4	-2.5	-0.7	-4.0	-2.9	-2.9	-3.4
Alcohol intake frequency.	0.2	0.5	2.4	1.0	-1.0	0.8	-1.6	-0.3	-0.6	0.2	0.6	-0.1	-0.1	-0.5	0.1
Comparative height size at age 10	0.5	2.7	7.3	2.6	-2.1	1.6	-0.9	0.1	1.0	2.7	1.8	1.2	1.1	1.5	0.9
Number of full sisters	1.1	1.3	4.7	0.9	1.6	0.3	2.2	1.5	0.4	2.0	0.4	0.1	0.7	0.8	-0.1
Suffer from ‘nerves’	1.5	2.4	9.4	3.1	-0.5	2.4	-1.1	-1.7	-0.3	0.7	2.7	-0.5	0.6	0.4	-0.6
Overall health rating	1.0	2.2	13.4	1.0	-1.6	0.8	-3.7	-0.7	1.2	-1.1	1.8	0.6	0.6	0.4	0.9
Chest pain or discomfort	1.3	1.8	5.4	2.2	-0.0	1.9	-2.3	-0.9	0.2	-0.1	2.0	0.9	1.2	0.0	0.8
Had major operations	0.7	0.8	3.0	1.2	0.8	0.7	0.1	0.5	0.7	1.1	1.0	0.6	0.7	1.7	0.3
Age at last live birth	1.2	1.7	5.1	0.6	-1.1	-0.1	0.0	0.4	1.5	0.5	1.0	2.1	1.6	1.8	2.3
Family relationship satisfaction	0.5	0.6	1.4	-0.9	-0.1	-0.3	-0.9	0.1	0.7	-0.5	-0.9	-0.8	-1.2	-1.0	-0.9
Leg pain on walking	0.8	1.0	4.5	-0.8	0.7	-0.6	-2.1	0.4	-0.2	-1.8	-0.8	-0.4	-0.6	-1.0	-0.3
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.3	0.2	-0.5	0.1	0.0	0.3	0.3	0.3	0.2	0.3	-0.3	-0.5	0.2
Commuting to job workplace: Car/motor vehicle	1.5	1.7	6.5	2.4	0.6	2.5	-0.3	-1.0	-0.0	1.4	1.9	-0.6	0.7	-0.4	-0.7
Illness, injury, bereavement, stress in last 2 years	2.4	2.9	8.1	-0.3	-0.4	1.0	-1.4	-2.1	-2.8	-1.3	-1.0	-2.2	-2.2	-1.1	-2.3
Medication: Aspirin	1.4	1.8	7.0	1.8	-2.6	1.1	-0.9	-1.5	-0.6	-0.7	1.8	0.8	0.9	0.8	0.9
Supplements: Vitamin C	0.8	1.0	5.1	0.4	-2.2	1.1	-0.5	-1.5	-0.7	-0.6	1.1	-0.4	0.3	0.4	0.2
Knee pain experienced in last month	0.5	0.8	2.5	1.4	0.5	1.6	-1.5	-0.2	-0.1	-1.1	0.8	0.5	0.3	0.1	0.4
Hypertension (Self-reported)	1.0	2.7	7.5	1.3	-1.5	2.7	-1.1	-1.9	-2.4	-0.0	1.3	-2.0	-0.6	-1.4	-1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	2.0	0.7	1.0	-0.0	0.8	0.7	0.7	1.2	0.6	1.1	1.2	1.4	0.9
Illnesses of father: Heart disease	0.5	0.7	3.7	1.9	-0.5	1.4	0.2	-0.6	0.1	0.3	1.3	-0.0	0.0	0.6	-0.4
Illnesses of siblings: Diabetes	3.3	4.0	10.9	-2.4	-1.5	-1.8	-2.0	1.3	-0.8	-2.1	-3.3	-1.4	-2.9	-1.6	-1.6
Smoking status: Previous	1.1	1.6	4.7	-0.3	-1.1	0.5	0.1	-0.9	-2.0	-0.1	-0.8	-1.5	-2.2	-1.0	-2.2
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	4.5	0.2	0.9	-1.0	0.2	2.1	1.3	1.7	-0.5	1.4	0.7	0.8	1.1
Whole body fat-free mass	0.3	2.0	6.7	-0.0	-2.6	0.4	-2.5	-1.3	-0.7	-2.3	-0.3	-0.9	-0.9	-1.1	-0.3
Leg fat-free mass (right)	0.2	0.9	3.8	0.2	-1.9	0.2	-1.9	-0.8	-0.1	-1.5	-0.0	-0.4	-0.3	-0.7	0.2
Arm fat percentage (left)	0.1	0.3	1.1	0.5	0.2	0.2	-0.6	0.8	1.1	0.7	-0.1	0.4	0.3	0.2	0.4
Average weekly red wine intake	1.3	2.0	5.3	1.7	-0.2	1.7	1.3	-0.9	0.5	1.0	2.3	0.1	2.2	1.8	0.9
Handedness (chirality/laterality): Left-handed	1.7	2.0	4.6	0.6	-0.6	-0.0	0.7	0.9	2.0	0.3	1.5	1.8	2.0	2.1	2.0
Mood swings	2.1	3.8	13.9	2.2	0.7	1.7	0.5	-1.1	1.8	0.3	3.7	1.6	2.7	2.1	2.2
Loneliness, isolation	0.5	0.8	2.4	0.9	-0.4	0.2	-1.2	0.0	1.6	0.3	1.4	0.5	1.0	0.6	0.8
Long-standing illness, disability or infirmity	0.7	1.1	8.2	1.3	-0.4	1.3	-2.9	-0.3	0.4	0.4	1.1	-0.2	-0.2	-0.2	-0.6
Ever had bowel cancer screening	1.4	1.6	3.8	1.7	-1.6	1.1	-0.6	-0.7	0.1	0.4	1.9	0.9	1.4	1.9	1.3
Diabetes diagnosed by doctor	0.5	0.9	2.9	1.3	-1.0	1.6	-1.7	-0.5	0.5	0.4	1.1	-0.1	-0.3	-0.4	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	2.2	-0.2	-1.3	0.2	-1.5	-0.0	-0.8	-0.4	-0.5	-0.9	-0.9	-0.6	-0.9
Friendships satisfaction	1.9	2.3	7.1	-1.9	0.1	-1.1	-0.9	0.4	0.2	-1.2	-2.5	-1.2	-2.7	-1.8	-1.6
Qualifications: nursing, teaching	0.4	0.7	1.8	-0.0	0.6	-0.7	1.1	0.6	-0.7	0.1	0.1	0.9	1.3	1.2	1.0
Commuting to job workplace: Walk	0.8	0.9	2.8	-1.2	0.8	-1.7	0.6	0.4	0.1	-1.4	-0.3	1.3	0.2	0.5	1.2
Eye problems/disorders: Cataract	0.7	0.8	5.5	-0.0	-0.9	0.1	-2.3	-0.6	-0.1	-1.5	0.3	-0.1	-0.6	-0.2	-0.2
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.6	-0.1	0.3	-0.2	-0.6	0.4	0.8	0.3	-0.4	0.5	-0.2	0.1	0.4
Medication for cholesterol	1.3	1.9	6.1	0.1	1.7	-1.1	-0.1	1.3	2.5	1.1	0.2	1.9	1.4	1.5	1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	3.4	1.0	-1.3	1.8	-0.2	-0.6	-1.5	0.4	0.3	-1.0	-1.6	-0.8	-1.6
Back pain experienced in last month	1.9	2.8	8.3	-1.8	-0.9	-0.3	-1.8	0.1	-1.3	-1.5	-1.9	-1.6	-2.9	-2.1	-2.0
Mineral and other dietary supplements	1.6	2.1	5.1	-2.0	0.0	-1.0	-0.4	-0.0	-1.1	-1.5	-2.3	-1.5	-1.9	-2.0	-1.5
Breast cancer (self-reported)	1.4	1.7	5.5	1.8	-0.0	2.4	1.0	-1.8	-0.9	0.9	1.7	-1.0	0.3	-0.1	-1.2
Asthma (self-reported)	0.1	0.3	1.1	0.4	0.8	0.0	-0.4	0.0	0.3	1.0	0.4	0.2	0.1	0.8	-0.1
Osteoporosis (self-reported)	1.4	1.8	4.4	2.0	-1.3	1.8	-1.0	-2.0	0.5	-0.3	2.1	0.4	1.1	1.0	0.6
Osteoarthritis (self-reported)	1.1	1.4	7.2	1.7	-0.5	1.5	-2.7	-1.3	0.8	-1.1	0.9	0.2	-0.0	0.6	0.0
Medication: Aspirin	1.5	2.0	6.8	2.0	-2.6	1.6	-0.9	-1.6	-1.0	-0.6	2.0	0.4	0.9	0.4	0.6
Medication: Gliclazide	0.6	0.7	3.5	0.3	0.3	0.2	0.3	1.2	1.9	1.3	0.6	0.2	0.7	-0.0	0.3
Illnesses of father: None of the above (group 1)	0.4	0.5	1.6	-0.2	0.7	0.0	0.4	0.9	0.2	0.8	0.1	0.6	1.3	0.4	1.1
Smoking status: Current	0.4	0.6	1.4	1.1	0.1	1.2	-1.1	0.5	0.7	0.5	1.2	0.5	0.7	-0.1	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	2.9	-0.7	-0.7	-0.6	0.5	-0.1	0.5	-0.2	-1.2	-0.7	-1.3	-1.7	-1.0
Whole body water mass	0.3	1.8	6.7	0.1	-2.6	0.4	-2.5	-1.2	-0.6	-2.3	-0.1	-0.8	-0.7	-0.9	-0.1
Leg predicted mass (right)	0.2	1.0	3.9	0.1	-2.0	0.2	-1.9	-0.8	-0.1	-1.5	-0.1	-0.4	-0.3	-0.7	0.2
Arm fat mass (left)	0.1	0.4	1.9	0.8	-0.8	0.6	-1.4	0.1	0.9	-0.1	0.2	0.2	0.3	0.1	0.4
Number of self-reported non-cancer illnesses	1.6	2.8	11.2	1.5	-0.6	2.1	-3.3	-2.3	-1.9	-0.0	1.1	-1.5	-0.9	-0.3	-1.6
Average weekly champagne plus white wine intake	1.7	2.3	5.2	1.7	-0.3	1.4	2.0	-0.3	-0.5	1.1	1.9	1.5	2.3	1.7	1.6
Miserableness	0.8	1.4	5.2	0.9	-0.7	0.7	-2.3	-2.2	-0.1	-1.2	1.5	0.1	0.7	0.0	0.8
Guilty feelings	1.4	2.1	6.1	2.0	-1.5	2.0	-1.3	-2.5	-0.4	-0.2	2.5	-0.4	0.9	0.5	0.2
Wears glasses or contact lenses	0.4	0.4	1.7	-0.4	-0.6	0.3	-1.3	-0.6	-1.0	-0.6	-0.2	-0.1	-1.1	-0.3	-0.3
Ever taken oral contraceptive pill	1.5	1.7	3.4	-1.5	-1.6	-0.8	-0.6	0.2	-1.6	-0.9	-1.4	-0.9	-1.8	-1.8	-1.2
Hearing aid user	0.6	0.7	2.2	-0.9	-0.7	-0.4	-0.4	-1.0	-1.2	-1.5	-0.7	-0.7	-0.9	-0.2	-0.5
Mother’s age at death	1.1	1.3	3.8	-1.5	-2.0	-0.9	-0.1	-0.3	-1.0	-1.8	-1.1	-0.5	-1.4	-1.1	-0.3
Financial situation satisfaction	0.9	1.1	4.3	-1.8	0.8	-2.1	0.0	0.9	1.6	-0.3	-1.1	0.5	-0.3	-0.1	0.6
Tinnitus: Yes, now most or all of the time	0.7	0.8	2.0	1.4	1.3	0.7	0.7	-0.1	0.3	1.4	1.1	0.7	1.0	0.5	0.5
Commuting to job workplace: Public transport	0.2	0.2	1.4	-0.3	-1.2	-0.5	-0.4	-0.3	-0.1	-0.6	-0.4	0.2	-0.6	-0.1	-0.1
Eye problems/disorders: Glaucoma	0.4	0.5	2.2	-1.3	0.1	-1.5	-0.5	-0.3	0.4	-0.7	-0.9	0.2	-0.4	0.2	0.5
Medication: Blood pressure	0.9	1.8	5.4	0.8	-1.6	2.1	-0.3	-1.6	-2.3	-0.5	1.0	-1.6	-0.6	-0.6	-1.1
Pain type(s) experienced in last month: Hip pain	2.4	3.1	6.2	0.9	-1.0	1.4	-2.5	-1.6	-1.4	-1.4	-0.2	-2.3	-2.3	-2.0	-2.5
Supplements: Fish oil (including cod liver oil)	0.6	0.7	2.2	1.2	-0.2	0.6	-0.1	0.0	1.2	1.5	1.2	0.8	0.7	0.5	0.6
High cholesterol (Self-reported)	0.2	0.4	2.1	1.4	0.4	1.0	-0.6	-0.4	-0.2	0.4	0.9	0.4	0.3	0.3	0.1
Medication: Bendroflumethiazide	2.2	3.3	8.9	-0.4	-2.8	0.7	-1.3	-2.1	-3.0	-2.5	0.1	-1.7	-1.4	-1.9	-1.3
Medication: Paracetamol	0.4	0.7	2.0	0.7	-0.2	1.1	-0.4	-0.8	-0.0	-1.1	1.4	1.0	0.6	0.3	0.9
Medication: Lisinopril	0.3	0.4	1.9	-0.1	0.5	-0.1	0.3	0.6	1.4	1.3	0.2	0.3	0.6	-0.0	0.5
Medication: Atorvastatin	0.3	0.4	1.1	-1.0	-1.1	-0.7	-0.7	-0.2	0.1	-0.9	-0.4	-0.4	0.1	-0.5	0.3
Illnesses of father: High blood pressure	0.2	0.3	1.3	0.3	0.6	-0.3	-0.6	-0.1	1.2	0.7	-0.2	-0.1	-0.5	-0.5	-0.4
Alcohol drinker status: Never	0.4	0.5	1.4	0.0	0.3	0.5	-0.7	-1.2	-0.6	-1.1	0.4	0.2	0.7	-0.1	0.9
Ever smoked	0.3	0.5	1.8	0.1	-0.9	0.7	-0.6	-0.2	-0.5	-0.1	-0.6	-0.8	-1.3	-0.6	-1.3
Basal metabolic rate	0.2	1.3	5.3	0.3	-2.2	0.5	-2.3	-1.0	-0.3	-1.8	-0.1	-0.6	-0.6	-0.8	-0.1
Leg fat percentage (left)	0.1	0.4	1.4	1.1	0.4	0.8	-1.2	0.1	-0.2	0.7	0.4	-0.2	0.2	0.2	-0.1
Arm fat-free mass (left)	0.6	2.8	8.4	0.5	-2.7	1.1	-2.9	-2.0	-1.1	-2.6	0.2	-1.4	-0.9	-1.2	-0.6
Number of operations (self-reported)	0.7	1.1	2.4	-0.1	-1.4	0.8	-1.3	-1.6	-0.7	-1.1	-0.2	-1.0	-1.4	-0.4	-1.3
Average weekly beer plus cider intake	0.3	0.4	4.0	0.2	2.0	-0.3	0.1	0.4	0.6	0.4	-0.3	-0.2	-0.2	0.3	-0.3
Irritability	1.8	3.1	10.0	2.2	0.3	1.3	-0.6	-1.8	1.9	0.1	3.2	1.4	2.4	1.3	1.9
Risk taking	0.5	0.7	2.6	0.3	-0.6	1.3	0.7	-1.4	-1.6	0.1	1.2	-0.5	0.3	0.3	-0.2
Ever had prostate specific antigen (PSA) test	1.7	2.0	5.4	1.0	-0.2	-0.3	0.4	1.1	1.8	1.7	0.7	2.3	1.4	1.9	2.0
Fractured/broken bones in last 5 years	0.7	0.9	2.8	1.7	0.6	1.2	-0.1	-0.1	-0.1	1.5	1.5	0.3	0.8	1.0	-0.0
Age started oral contraceptive pill	0.5	0.6	1.4	-0.3	-0.8	0.3	-0.2	-0.5	-1.0	-0.8	-0.2	-1.0	-0.9	-1.0	-1.2
Diastolic blood pressure, automated reading	1.6	5.1	14.0	-0.6	-0.6	1.0	-1.8	-1.7	-2.1	-1.9	-1.3	-3.7	-2.8	-3.0	-3.6
Ever depressed for a whole week	1.0	1.2	3.2	1.3	0.8	0.9	1.1	0.2	0.8	1.3	1.7	0.8	1.8	0.6	1.0
Unable to work because of sickness or disability	0.5	0.7	1.4	0.7	-0.6	1.0	-0.5	-0.8	-1.2	-0.6	1.0	-0.7	-0.5	-0.4	-1.1
Commuting to job workplace: Cycle	1.4	1.7	4.4	0.3	1.6	-0.3	2.1	1.4	0.8	1.1	0.3	1.6	1.2	1.8	1.4
Myopia	0.5	0.7	2.2	1.4	-0.0	0.3	-1.5	0.1	-0.4	1.4	0.4	0.4	-0.2	1.4	-0.3
Vascular/heart problems diagnosed by doctor	1.1	2.9	7.3	-1.4	1.6	-2.7	1.4	2.4	2.6	0.4	-1.7	1.7	0.3	0.8	1.3
Cholesterol lowering medication	0.3	0.5	1.5	0.6	-1.0	0.7	-0.7	-0.8	-1.2	-0.2	0.1	-0.7	-0.7	-0.2	-0.9
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	4.7	1.5	-0.3	0.8	-0.5	-0.0	-0.3	-0.1	1.4	0.7	1.3	2.2	1.0
Pain experienced in last month	0.8	1.3	2.7	-0.6	0.4	-1.3	1.6	1.6	0.9	1.6	-0.3	0.9	1.1	1.0	1.2
Supplements: Calcium	1.3	1.5	5.0	1.9	-1.2	2.2	0.4	-1.4	-1.0	0.6	1.5	-0.5	0.5	1.2	-0.5
Basal cell carcinoma (self-reported)	1.1	1.3	2.4	0.8	0.2	0.5	1.5	0.7	1.5	1.0	1.1	1.3	1.4	1.5	1.4
Heart attack/myocardial infarction (self-reported)	1.0	1.3	4.6	1.4	-0.7	1.4	-1.1	-1.1	0.3	-0.3	2.1	0.8	1.3	1.0	0.9
Deep venous thrombosis (DVT) (self-reported)	0.3	0.3	1.3	-0.1	1.1	-0.0	-0.7	0.3	-0.8	0.0	-0.7	0.2	-0.9	-0.1	-0.6
Heart disease (siblings)	2.5	3.0	9.4	-1.3	-0.3	0.1	-1.2	-0.6	-1.0	-0.8	-2.4	-2.4	-3.1	-1.9	-2.6
Alcohol drinker status: Previous	0.9	1.0	3.2	1.4	-0.5	0.4	0.5	0.6	-0.5	1.8	1.4	0.4	1.4	1.2	0.7
Pack years of smoking	0.3	0.5	2.6	0.0	-1.3	0.5	-1.6	-0.7	0.5	-0.7	0.6	-0.1	0.0	-0.2	0.4
Impedance of whole body	2.3	11.5	49.5	1.8	3.7	-0.1	4.6	3.9	2.0	7.0	1.2	3.0	2.9	2.9	2.0
Leg fat mass (left)	0.1	0.4	2.0	1.1	-0.2	1.0	-1.4	-0.3	-0.1	0.2	0.4	-0.4	0.2	-0.2	-0.1
Arm predicted mass (left)	0.5	2.5	8.4	0.1	-2.6	0.7	-2.9	-1.6	-1.0	-2.5	-0.2	-1.3	-1.1	-1.2	-0.7