Hub : Genes

SGTB

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1200 0.0340 6.3e-10 0.070 0.093 0.093 0.091 0.092 6.4e-09 2.4e-11 2.0e-11 3.3e-11 2.5e-11
2 GTEx Adipose Subcutaneous 0.0910 0.0390 1.7e-03 0.016 NA 0.039 NA 0.039 1.7e-02 NA 3.8e-04 NA 3.6e-04
3 GTEx Brain Cortex 0.2570 0.0760 3.3e-05 -0.005 NA 0.065 NA 0.064 4.5e-01 NA 7.5e-03 NA 7.8e-03
4 GTEx Cells Transformed fibroblasts 0.1500 0.0550 7.1e-04 -0.003 NA 0.018 NA -0.003 7.6e-01 NA 1.6e-02 NA 6.0e-01
5 GTEx Heart Left Ventricle 0.0966 0.0546 5.6e-03 0.021 NA 0.006 NA 0.028 2.7e-02 NA 1.4e-01 NA 1.2e-02
6 GTEx Muscle Skeletal 0.0990 0.0407 4.0e-03 0.020 NA 0.026 NA 0.038 3.8e-03 NA 1.3e-03 NA 1.1e-04
7 METSIM Adipose 0.0338 0.0161 9.5e-03 0.000 0.011 0.010 0.012 0.003 3.9e-01 6.5e-03 8.9e-03 4.7e-03 8.6e-02
8 ROSMAP Brain Pre-frontal Cortex 0.2181 0.0372 0.0e+00 0.199 0.292 0.323 0.304 0.322 5.6e-25 6.5e-38 1.6e-42 1.3e-39 2.5e-42
9 TCGA Breast Invasive Carcinoma 0.0663 0.0242 6.4e-09 0.040 0.045 0.046 NA 0.038 9.1e-09 1.1e-09 1.1e-09 NA 2.5e-08
10 TCGA Kidney Renal Clear Cell Carcinoma 0.0559 0.0295 3.8e-04 0.013 0.034 0.021 NA 0.014 1.2e-02 9.4e-05 1.8e-03 NA 8.7e-03
11 TCGA Brain Lower Grade Glioma 0.1354 0.0571 2.6e-05 0.029 0.047 0.035 NA 0.019 2.5e-04 4.5e-06 6.1e-05 NA 2.7e-03
12 TCGA Thyroid Carcinoma 0.1060 0.0480 1.0e-05 0.024 0.051 0.040 NA 0.025 2.0e-03 1.0e-05 8.4e-05 NA 1.8e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bipolar Disorder (2018) 1.4 2.2 10.0 2.9 -0.2 3.2 -0.2 -1.0 -0.6 0.9 2.1 -0.6 0.8 0.8 -0.5
Bipolar Disorder or Schizophrenia 1.4 3.3 11.1 3.3 0.1 3.3 1.3 -0.8 -0.7 1.2 2.9 0.4 1.4 1.9 0.1
Depressed Affect (Nagel 2018) 1.4 2.9 10.2 1.9 -0.3 1.2 -0.8 -1.0 2.1 0.1 3.2 1.2 2.5 1.2 1.9
Depression (Nagel 2018) 0.2 0.3 1.7 0.3 0.1 0.6 -0.0 -0.3 0.7 -0.5 1.3 0.2 0.7 0.5 0.5
Intelligence (Savage-Jansen 2018) 0.7 2.1 6.5 -2.0 0.4 -0.9 0.1 0.6 -1.0 -1.3 -2.5 -0.6 -2.2 -2.0 -1.1
Neuroticism (Nagel 2018) 2.9 6.8 24.4 4.1 -0.3 2.9 -0.8 -2.1 2.0 0.4 4.9 1.5 3.2 2.4 2.1
Schizophrenia (2018) 0.8 1.7 4.0 1.9 0.1 1.7 2.0 -0.2 -0.3 0.9 2.0 0.9 1.1 1.8 0.5
Schizophrenia vs Biploar Disorder 0.2 0.2 1.0 0.0 0.4 -0.4 0.6 1.0 0.5 -0.0 0.5 -0.2 0.5 -0.2 0.2
Worry (Nagel 2018) 3.7 7.9 26.9 4.9 0.1 3.6 0.1 -1.8 1.3 1.0 5.2 1.8 3.4 2.6 1.8
Alzheimer’s Disease (in mother) 0.8 0.9 2.3 -0.1 -1.1 -0.6 -1.5 0.2 1.4 -0.9 0.3 1.0 0.8 1.2 1.3
Alzheimer’s Disease (in father) 1.0 1.1 2.5 -1.5 -1.1 -1.4 -1.5 0.8 0.6 -1.6 -1.0 0.2 -0.5 -0.7 0.4
Alzheimer’s Disease (including proxy) 1.0 1.4 3.8 -0.6 -1.3 -1.0 -1.9 0.7 1.6 -1.5 -0.1 1.1 0.5 1.1 1.3
Crohns Disease (2017) 0.6 1.4 4.4 1.4 0.5 0.8 -0.2 0.5 0.6 1.1 1.6 1.4 2.1 0.5 1.6
Irritable Bowel Disease (IBD) 0.2 0.5 1.4 0.6 -0.1 0.0 -0.8 -0.6 -0.3 -0.9 0.8 0.9 1.0 0.3 1.2
Ulcerative Colitis (UC) 0.6 1.2 5.7 -0.5 -0.7 -0.6 -1.1 -1.7 -1.7 -2.4 -0.4 -0.2 -0.5 -0.1 0.1
Major Depression (MDD) 1.8 2.2 6.1 2.2 -1.2 1.7 -0.5 -1.5 0.6 0.9 2.5 1.2 1.9 0.9 1.3
Reaction Time 1.5 2.9 7.3 -2.0 2.4 -0.9 0.6 1.8 -1.8 0.5 -2.0 -1.0 -1.6 -2.7 -1.6
Verbal and Numeric Reasoning (VNR) 0.4 0.9 3.6 -1.4 0.7 -0.7 0.0 0.9 -0.1 -0.1 -1.9 -0.6 -1.4 -0.9 -0.9
Breast Cancer 0.2 0.4 1.4 -0.5 1.0 -0.8 -0.6 0.4 -1.2 0.6 -0.6 -0.6 0.0 -0.1 -0.2
Ovarian Cancer 2.5 3.3 7.4 1.8 1.4 0.7 0.3 0.8 1.8 2.3 1.9 1.8 2.5 2.7 2.1
Prostate Cancer 0.3 0.4 1.2 0.5 -1.1 1.0 0.8 -0.3 0.6 -0.3 0.9 0.4 0.5 0.2 0.6
Age at First Birth 3.1 4.6 10.6 1.6 1.6 -0.3 0.7 0.6 2.6 1.4 2.0 3.3 2.9 2.7 3.1
Bipolar Disorder (2011) 0.9 0.9 2.9 1.0 -0.7 0.9 0.9 0.3 1.7 1.0 0.9 0.4 0.9 1.1 0.5
Body Mass Index (BMI) (2010) 3.7 5.0 9.1 -2.0 -1.0 -0.6 -2.4 -1.9 -0.8 -3.0 -2.2 -2.6 -3.0 -3.0 -2.6
Coronary Artery Disease (CAD) 1.7 2.0 4.3 1.4 -2.1 0.8 -1.6 -1.6 1.2 -0.4 1.8 1.0 1.2 1.6 1.4
Crohns Disease (2012) 0.6 1.0 2.6 1.3 0.2 1.2 -0.0 0.4 0.2 1.4 1.4 1.0 1.6 0.7 1.0
Mean Putamen Volume 1.0 1.2 5.4 -1.0 2.3 -1.2 -1.0 0.5 1.3 0.3 -1.6 0.1 -0.9 -0.3 0.0
Fasting Glucose 2.5 3.0 5.5 -1.6 -1.6 0.1 -1.9 -1.4 -2.3 -1.8 -1.3 -2.3 -1.7 -1.8 -1.8
HbA1C 0.3 0.3 2.1 -0.3 1.4 -0.2 0.2 0.4 1.0 0.4 -0.3 0.3 0.5 -0.0 0.1
HDL Cholesterol 0.8 1.3 4.6 0.3 0.0 -0.6 0.7 0.5 0.5 0.6 0.9 1.1 1.9 2.1 1.8
LDL Cholesterol 0.4 0.7 2.2 -1.5 -1.0 -1.0 -0.6 -0.3 0.6 -0.4 -0.7 -0.4 -0.9 -1.3 -0.4
Lupus 0.1 0.2 0.5 -0.5 -0.2 -0.6 0.2 0.4 0.7 -0.4 0.0 0.3 0.5 -0.1 0.6
Neuroticism (2016) 0.6 0.9 3.2 1.2 0.4 1.8 0.2 -1.6 -0.3 0.2 1.7 -0.5 0.4 -0.1 -0.1
Primary Biliary Cirrhosis 0.6 0.9 2.5 1.2 -1.6 0.8 -0.3 0.0 0.8 -0.0 1.4 0.7 1.2 0.7 1.1
Rheumatoid Arthritis 0.9 1.3 3.9 -1.8 0.5 -2.0 -0.9 0.6 0.1 -1.7 -1.6 0.4 -0.1 0.0 0.9
Schizophrenia (2014) 1.2 2.7 5.5 1.7 1.3 0.7 2.0 1.0 0.5 1.4 1.8 2.1 1.9 2.3 1.6
Triglycerides 1.1 1.8 6.4 0.4 -0.2 1.4 -0.7 -1.2 -1.4 0.4 0.2 -1.8 -1.3 -2.5 -2.0
Type 2 Diabetes (T2D) (2012) 0.3 0.4 2.6 0.2 0.1 -0.2 0.2 -0.1 1.6 -0.0 0.0 0.8 0.5 0.3 0.9
Ulcerative Colitis 0.9 1.3 3.1 -0.1 -1.3 0.0 -1.6 -1.5 -1.6 -1.8 -0.6 -0.7 -1.2 0.0 -0.8
Blood Eosinophil Count 0.2 1.2 3.4 -1.7 -0.4 -1.8 0.1 1.0 -0.7 -0.0 -1.8 -0.2 -1.3 -1.1 -0.6
Blood Platelet Count 0.2 2.6 6.9 -0.9 1.8 -2.4 0.1 2.0 2.6 -0.3 -1.0 2.3 1.0 0.6 1.8
Blood Red Count 0.3 2.5 8.0 2.5 -1.4 2.8 -1.3 -1.9 0.2 0.8 2.1 -1.3 0.4 -0.6 -1.0
Blood White Count 0.2 1.7 4.9 -0.4 -1.2 0.8 -2.2 -1.1 -1.8 -0.3 -0.1 -1.5 -1.3 -1.8 -1.5
Heel T-Score 0.4 3.5 12.1 -1.7 -0.2 -1.6 -1.1 0.1 -0.3 -1.9 -3.5 -1.1 -3.2 -2.2 -1.7
BMI 0.8 4.6 15.1 -0.7 -1.2 0.7 -2.7 -2.4 -1.5 -3.9 -0.9 -2.5 -2.3 -2.4 -2.0
Height 0.7 12.6 42.2 3.6 0.2 0.8 3.0 3.3 3.7 6.5 2.5 4.4 3.7 3.5 3.3
Waist Hip Ratio (WHR) 0.8 3.8 18.3 1.0 -0.2 0.3 -0.2 2.3 0.3 4.3 1.8 1.7 2.1 2.5 2.0
Systolic Blood Pressure 0.5 2.5 6.7 0.5 -0.1 1.4 -1.7 -1.3 -2.1 0.4 -0.3 -2.6 -1.8 -1.4 -2.6
Smoking Status 0.3 0.7 2.9 1.5 -0.4 1.7 -0.4 -0.2 -0.4 0.6 1.0 -0.3 -0.3 -0.4 -0.8
Allergy or Eczema 0.2 0.4 1.9 0.4 0.5 0.7 1.4 -0.3 -0.1 0.8 0.8 0.2 0.8 0.2 0.2
Cardiovascular Disease 0.9 2.9 7.4 1.7 -0.2 2.7 -0.4 -2.0 -2.3 0.8 1.3 -2.4 -0.4 -1.6 -2.0
Hypothyroidism (self reported) 0.7 1.5 5.8 1.4 1.9 1.4 0.4 1.1 0.3 2.4 0.2 -0.7 -0.1 -0.8 -1.5
Respiratory disease 0.2 0.4 2.8 0.6 -0.4 0.6 -1.7 -0.2 0.4 0.1 0.6 -0.1 -0.0 0.3 -0.3
Type 2 Diabetes (T2D) (2018) 0.8 1.5 4.7 2.1 -0.3 2.2 -1.6 0.1 0.1 1.3 1.9 0.6 0.7 0.2 0.4
Lung FEV1/FVC ratio 0.3 1.4 4.6 -0.5 -2.0 0.0 -0.8 -2.1 -1.7 -1.9 -0.2 -0.5 -0.6 0.2 0.4
Lung FVC 0.7 3.5 8.0 -1.4 1.3 -2.6 1.5 2.8 2.5 1.7 -2.6 0.9 -1.4 -1.8 -0.3
Neuroticism 2.3 5.6 18.2 3.4 0.2 2.3 -0.2 -1.3 1.8 0.3 4.3 2.0 3.3 2.4 2.7
Chronotype (morning person) 0.9 2.0 9.4 -1.1 1.9 -1.7 1.1 3.1 0.8 1.1 -1.3 1.1 0.5 -0.0 0.6
Hair Pigment 0.0 0.7 2.1 1.2 0.6 1.3 -0.7 0.5 0.0 1.5 1.1 0.2 0.7 0.8 0.2
Tanning 0.0 0.2 0.8 -0.3 0.6 -0.4 0.2 0.2 0.9 0.3 -0.4 0.4 -0.0 0.1 0.1
Hand grip strength (left) 1.5 4.0 9.1 -0.9 -2.2 0.1 -2.1 -1.9 -1.0 -2.7 -1.0 -2.4 -2.4 -3.0 -2.2
Number of treatments/medications taken 0.5 0.8 2.3 1.5 -0.1 1.4 -0.6 -0.9 -0.7 -0.0 1.5 0.9 0.7 0.3 0.4
Average weekly spirits intake 0.6 0.7 3.4 0.8 -1.8 1.1 -1.3 -0.7 0.4 0.2 0.8 0.3 -0.2 -0.2 0.1
Sensitivity / hurt feelings 1.0 1.8 5.5 1.8 1.0 1.2 0.8 -1.1 0.0 0.1 2.4 0.9 1.6 1.9 1.0
Frequency of depressed mood in last 2 weeks 0.6 0.8 3.3 0.8 0.6 0.9 -0.4 -0.7 1.1 -0.3 1.8 0.4 0.8 1.0 0.7
Hearing difficulty/problems: Yes 0.4 0.5 1.6 -0.7 0.6 -0.4 -0.4 0.4 -0.4 0.1 -0.9 -1.0 -1.3 -0.3 -1.1
Relative age of first facial hair 0.4 0.8 4.6 -1.5 0.8 -0.8 2.1 0.2 -0.5 -0.6 -0.2 -0.1 0.4 -0.3 0.5
Other serious medical condition/disability diagnosed by doctor 1.4 1.8 5.0 1.7 -2.2 1.4 -1.9 -2.0 -0.7 -0.9 1.4 -0.3 -0.3 0.0 -0.5
Ever used hormone-replacement therapy (HRT) 0.3 0.4 1.2 -0.3 -1.0 0.4 -0.2 0.3 -0.6 -0.1 -0.4 -0.9 -1.1 -0.3 -0.9
Ever had hysterectomy (womb removed) 0.5 0.6 2.2 -1.0 -1.5 -0.4 -0.3 -0.3 -0.8 -1.4 -0.4 -0.3 -0.4 -0.4 -0.0
Systolic blood pressure, automated reading 0.6 1.8 5.4 -0.3 -0.3 0.7 -1.4 -1.0 -1.4 -0.7 -0.9 -2.3 -1.6 -1.4 -2.1
Eye problems/disorders: Diabetes related eye disease 0.2 0.3 0.7 0.7 0.4 0.2 0.6 0.2 0.8 0.1 0.8 0.7 0.5 -0.0 0.4
Angina 1.2 1.5 5.1 2.3 -1.5 1.9 -0.5 -0.1 0.5 1.2 1.8 0.9 0.8 0.5 0.4
Medication for hormone replacement therapy 1.1 1.3 5.4 -0.4 1.2 -0.8 2.3 2.1 0.2 1.3 -0.6 0.6 0.3 0.3 0.4
Vitamin and mineral supplements 0.4 0.5 1.7 0.2 0.6 1.0 0.3 0.0 -0.8 0.5 0.4 -1.3 -0.0 -1.2 -0.8
Supplements: Zinc 0.6 0.6 5.4 -1.0 -0.2 -0.7 2.3 0.2 0.2 0.5 0.0 0.3 0.6 -0.2 0.4
Medication: Co-codamol 0.7 0.8 3.3 1.6 0.2 1.1 -0.4 -0.4 0.4 0.2 1.8 0.5 0.5 1.0 0.2
Medication: Metformin 0.3 0.5 2.0 0.5 -0.6 0.5 -1.4 0.6 0.9 0.1 0.7 0.7 0.4 -0.1 0.9
Diabetes (father) 0.7 0.8 3.3 0.3 1.7 -0.3 1.8 0.8 0.3 0.5 0.4 0.4 1.1 0.9 0.5
Diabetes (mother) 0.3 0.4 1.2 -1.1 -0.1 -0.7 -0.2 0.3 0.6 -0.4 -1.0 -0.7 -0.7 0.2 -0.6
Severe depression (siblings) 0.5 0.6 1.9 1.3 -0.8 1.4 -1.1 -0.4 -0.2 -0.4 0.7 -0.5 -0.2 -0.0 -0.6
Pack years adult smoking proportion 0.3 0.5 2.2 0.4 -1.0 0.7 -1.5 -0.6 0.6 -0.3 0.9 0.0 0.1 -0.4 0.4
Impedance of leg (right) 1.2 5.7 30.5 1.8 3.0 0.6 2.9 2.7 0.9 5.5 0.8 1.5 1.6 1.9 0.4
Leg fat-free mass (left) 0.2 1.2 4.8 0.2 -2.2 0.3 -2.2 -0.9 -0.1 -1.7 -0.1 -0.4 -0.4 -0.7 0.2
Trunk fat percentage 0.5 2.2 9.4 1.8 0.9 0.9 0.5 1.4 1.4 3.1 1.1 1.2 1.5 1.4 1.0
Hand grip strength (right) 1.2 3.3 7.9 -0.6 -2.3 0.4 -1.7 -1.9 -0.7 -2.2 -0.8 -2.1 -2.2 -2.8 -2.0
Townsend deprivation index at recruitment 0.5 0.8 2.5 0.9 0.5 -0.1 -0.0 0.5 0.7 0.2 0.8 1.6 0.8 1.4 1.1
Current tobacco smoking 0.4 0.6 1.3 1.0 0.5 1.2 -1.1 0.8 1.0 0.7 1.0 0.4 0.6 -0.3 0.3
Average weekly fortified wine intake 1.5 1.7 3.7 1.9 -0.5 0.8 1.6 -1.5 -1.1 0.9 1.9 0.1 1.7 1.5 0.5
Maternal smoking around birth 0.4 0.6 2.2 1.5 -0.8 1.0 -0.9 -0.4 -0.0 0.6 1.1 -0.4 -0.2 0.4 -0.7
Fed-up feelings 0.7 1.3 4.1 0.2 0.1 -0.7 -0.5 -0.4 1.8 -0.5 1.1 1.7 1.2 1.2 2.0
Frequency of unenthusiasm / disinterest in last 2 weeks 0.3 0.4 1.0 0.1 1.0 0.0 0.5 0.5 0.4 0.5 1.0 0.6 0.7 0.7 0.7
Relative age voice broke 0.5 0.8 2.9 -0.5 1.6 -0.6 1.7 1.3 0.9 0.2 0.5 0.2 1.0 0.2 0.4
Taking other prescription medications 0.3 0.5 2.5 0.9 -0.0 0.8 -1.6 -0.6 -0.3 -0.1 0.6 -0.2 -0.3 0.8 -0.5
Age when periods started (menarche) 0.4 1.0 8.1 -0.4 1.1 0.1 2.9 0.9 0.6 0.7 0.3 0.7 0.5 0.4 0.2
Bilateral oophorectomy (both ovaries removed) 0.3 0.4 1.2 -0.3 -1.1 -0.4 -0.1 1.0 0.3 -0.4 -0.0 0.9 0.3 0.7 0.9
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.7 4.9 0.3 0.1 -0.2 2.2 0.7 0.1 0.3 -0.0 0.9 0.7 0.5 0.9
Tinnitus: Yes, but not now, but have in the past 0.5 0.6 2.4 -0.8 -0.0 -1.1 -1.5 0.7 -0.9 -0.3 -0.8 0.3 -0.5 -0.2 0.0
Qualifications: CSEs or equivalent 0.6 0.8 1.8 -0.8 -0.8 -1.0 -0.3 -0.5 0.5 -1.3 -0.9 -0.8 -1.2 -1.2 -1.0
Serious illness, injury or assault to yourself 1.2 1.4 3.9 0.3 -0.6 -0.2 0.3 1.0 1.0 -0.3 1.1 1.8 1.7 2.0 1.9
High blood pressure 1.0 2.7 6.5 1.2 -1.5 2.5 -1.2 -2.2 -2.4 -0.3 1.4 -2.0 -0.6 -1.2 -1.5
Hayfever, allergic rhinitis or eczema 0.2 0.5 1.7 0.8 0.4 1.3 1.1 -1.0 -0.1 0.5 0.8 -0.4 0.1 -0.4 -0.5
Multivitamins +/- minerals 0.3 0.3 0.9 0.2 1.0 -0.7 0.9 0.3 0.5 0.3 -0.5 0.8 -0.3 0.6 -0.0
Stomach or abdominal pain in last month 0.8 1.0 3.3 0.9 -1.3 0.4 -1.2 -1.8 0.0 -1.6 0.7 0.1 0.6 0.4 0.7
Supplements: Glucosamine 0.5 0.7 1.9 1.1 0.5 0.4 -0.1 -0.5 -0.0 -0.2 1.3 0.5 1.4 1.3 1.0
Diverticular disease/diverticulitis (self-reported) 5.1 6.1 13.1 1.4 -2.1 2.8 -2.7 -3.6 -2.1 -1.4 0.0 -2.9 -2.6 -2.6 -3.2
Medication: Atenolol 1.3 1.7 4.7 1.0 0.0 1.9 -0.6 -2.2 -1.4 -1.0 0.9 -1.5 -0.8 -1.3 -1.4
Medication: Levothyroxine sodium 0.6 1.1 3.8 2.0 0.7 1.6 -0.1 -0.3 -0.1 1.6 1.5 0.1 1.2 0.1 0.0
Sitting height 0.1 0.8 3.5 1.3 -0.8 0.9 0.8 0.6 -0.0 1.9 1.0 0.3 0.8 0.5 0.3
Chronic bronchitis/emphysema (father) 1.5 1.7 7.0 1.7 -0.6 2.0 0.2 -2.7 -0.4 -0.2 2.0 -0.9 -0.0 -0.6 -0.8
High blood pressure (mother) 1.0 1.4 8.1 1.4 0.2 2.8 0.2 -0.9 -0.5 0.2 1.3 -1.0 -0.7 -0.9 -1.4
Body mass index (BMI) 0.4 1.9 6.6 0.1 -1.3 0.8 -2.6 -1.4 -0.5 -2.2 -0.2 -1.4 -1.2 -1.2 -1.0
Impedance of leg (left) 1.6 7.8 40.2 1.9 3.7 0.7 3.7 2.9 0.9 6.3 1.2 1.5 2.1 2.1 0.6
Leg predicted mass (left) 0.2 1.3 5.2 0.1 -2.3 0.2 -2.3 -1.0 -0.2 -1.8 -0.2 -0.5 -0.5 -0.7 0.1
Trunk fat mass 0.2 1.1 4.0 1.4 -0.1 0.7 -0.4 0.9 1.1 2.0 0.7 0.8 1.0 0.9 0.9
Waist circumference 0.2 0.7 2.8 1.0 -1.3 0.8 -1.7 0.1 0.5 0.2 0.8 0.2 0.6 0.5 0.7
Number of incorrect matches in round 0.1 0.2 0.9 0.2 -0.2 -0.1 0.0 -0.0 0.7 -0.3 0.4 0.9 0.1 0.7 0.5
Past tobacco smoking 1.1 2.1 5.7 0.0 1.6 -0.9 0.8 1.2 1.7 0.5 0.5 1.7 2.3 1.4 2.4
Alcohol usually taken with meals 0.7 1.2 3.1 0.4 -1.6 0.6 1.0 -0.7 0.3 -0.5 1.4 1.3 1.6 0.7 1.8
Nervous feelings 0.9 1.7 5.6 2.4 0.1 2.2 -0.4 -1.7 -0.0 0.3 2.3 -0.4 0.4 0.5 -0.7
Frequency of tenseness / restlessness in last 2 weeks 0.7 1.0 3.9 0.7 0.2 1.0 0.7 -1.8 0.1 -0.8 2.0 0.2 0.9 1.2 0.4
Hearing difficulty/problems with background noise 0.3 0.5 1.3 0.3 0.4 0.1 1.0 -0.2 0.6 0.1 0.9 1.0 0.5 1.2 0.8
Hair/balding pattern: Pattern 2 0.5 0.6 1.5 0.8 0.6 0.9 1.1 -0.3 -1.2 0.2 0.6 -1.1 0.0 0.4 -1.1
Had menopause 0.6 0.8 3.1 0.2 -1.8 0.7 -1.2 -1.0 -0.8 -1.0 0.1 -1.1 -0.4 -0.0 -0.6
Had other major operations 1.2 1.4 3.9 0.0 -0.4 0.9 -1.3 -2.0 -1.6 -1.3 0.2 -1.4 -1.0 -1.0 -1.5
Forced vital capacity (FVC) 0.5 1.7 6.0 -0.4 1.0 -1.0 1.3 1.7 0.7 2.4 -1.6 0.2 -1.1 -1.8 -0.8
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.5 2.6 -0.1 0.4 0.2 1.6 0.2 -1.1 0.3 -0.9 -0.2 -0.6 -0.3 -0.4
Ever unenthusiastic/disinterested for a whole week 1.7 2.1 6.1 1.8 0.6 1.3 0.6 -0.2 1.7 1.1 2.5 0.9 2.0 1.4 1.4
Qualifications: None of the above 0.1 0.3 1.1 0.2 -0.0 0.5 -1.1 -0.5 -1.0 -0.6 0.0 -0.5 -0.5 -0.3 -0.4
Financial difficulties in last 2 years 0.7 0.9 4.6 0.5 0.9 0.4 2.1 -0.0 -0.0 1.2 1.0 0.9 1.1 0.2 0.8
Mouth/teeth dental problems 0.3 0.5 1.0 -0.6 0.0 0.4 0.7 -1.0 -0.4 -0.5 -0.3 -1.0 -0.7 -0.7 -1.0
Heart attack 0.9 1.1 3.8 1.1 -0.7 1.2 -1.2 -1.2 0.1 -0.5 2.0 0.7 1.2 0.9 0.8
Allergy 0.4 0.9 2.5 -1.1 0.1 -1.6 0.2 1.2 0.7 -0.6 -0.7 0.7 0.8 1.0 1.4
Pain all over the body in last month 0.5 0.5 1.4 0.2 1.0 -0.3 -1.0 1.2 0.7 0.6 0.1 1.1 0.4 0.5 0.7
Diabetes (self-reported) 0.6 0.9 6.5 0.5 -0.7 1.0 -2.5 -0.5 0.4 -0.3 0.4 -0.1 -0.7 -1.0 -0.3
Hayfever/allergic rhinitis (self-reported) 0.6 0.8 2.6 0.6 0.4 0.5 1.0 0.6 1.6 1.5 0.6 0.9 0.7 0.3 0.7
Medication: Ramipril 1.3 1.7 5.6 2.1 0.1 2.4 -0.2 -1.0 -0.5 0.4 2.4 0.2 1.6 0.9 0.5
Medication: Simvastatin 0.3 0.4 1.6 1.3 -0.5 0.8 -0.8 -0.5 -0.8 0.1 0.6 0.5 -0.0 0.1 0.2
Fluid intelligence score 0.4 0.7 2.6 -0.9 0.8 -0.3 0.4 0.8 0.3 0.0 -1.6 -0.5 -1.3 -0.6 -1.2
Illnesses of siblings 4.8 6.8 14.5 1.7 1.8 -0.0 2.7 0.5 1.8 2.1 2.7 3.7 3.8 3.2 3.7
Neuroticism score 1.6 3.4 11.4 2.5 0.1 1.4 -0.6 -1.5 1.4 -0.1 3.4 1.7 2.5 1.7 2.2
Weight 0.2 0.8 4.0 1.0 -1.6 0.9 -2.0 -0.4 0.2 -0.4 0.5 -0.2 -0.0 -0.2 0.2
Impedance of arm (right) 2.6 12.1 49.7 1.2 2.9 -1.1 4.2 4.6 2.9 7.0 0.7 3.8 3.0 2.7 2.7
Arm fat percentage (right) 0.1 0.3 1.1 0.4 0.1 -0.0 -0.5 1.0 1.0 0.8 -0.2 0.5 0.3 0.1 0.4
Trunk fat-free mass 0.4 2.3 7.2 -0.2 -2.6 0.3 -2.7 -1.3 -0.8 -2.6 -0.5 -1.0 -1.2 -1.0 -0.5
Hip circumference 0.1 0.4 2.2 0.5 -0.7 0.1 -0.6 0.4 1.5 -0.9 -0.1 0.3 0.4 0.1 0.5
Time employed in main current job 0.2 0.2 0.9 0.1 -0.4 0.0 -1.0 -0.6 0.4 -0.8 0.3 0.1 0.1 -0.2 0.2
Alcohol intake versus 10 years previously 0.8 1.2 3.8 -1.0 -0.1 -0.2 -1.4 0.2 -0.9 -0.6 -1.4 -1.1 -2.0 -1.1 -1.3
Father’s age at death 0.9 1.2 2.9 1.0 -0.8 0.5 0.8 -0.9 0.9 0.6 1.7 0.9 1.5 1.4 1.4
Worrier / anxious feelings 1.5 2.8 8.6 2.3 -1.6 1.6 -1.2 -2.1 0.6 -0.9 2.9 0.8 1.7 1.4 1.4
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.3 1.0 0.3 1.0 0.2 -0.5 -0.5 0.8 -0.5 0.8 0.3 -0.0 -0.2 0.1
Falls in the last year 0.4 0.5 2.8 -0.2 1.7 -0.6 -0.5 0.4 0.6 0.1 0.4 0.9 0.6 0.2 0.8
Hair/balding pattern: Pattern 3 0.4 0.5 2.1 -0.7 -0.5 -0.5 -1.4 -0.1 -0.1 -1.5 -0.3 0.5 -0.1 -0.7 0.7
Number of live births 1.0 1.3 3.0 1.2 0.5 1.3 0.9 -0.6 -1.1 0.7 1.7 0.6 1.7 1.5 1.1
Forced expiratory volume in 1-second (FEV1) 0.3 1.0 2.4 -0.5 0.4 -1.0 1.5 1.1 0.4 1.5 -1.3 0.3 -0.7 -1.4 -0.3
Pulse rate 1.4 2.3 7.3 -0.4 -2.7 0.8 -2.5 -1.9 -0.1 -1.6 -0.0 -1.5 -1.1 -1.4 -1.1
Happiness 2.0 2.5 6.7 -2.6 0.8 -1.9 -0.9 0.7 0.9 -1.6 -2.4 -1.2 -2.0 -1.2 -1.1
Noisy workplace 0.3 0.4 1.1 -0.7 0.7 -0.5 -0.9 -0.3 -1.1 -0.6 -0.5 -0.3 -0.1 -0.4 -0.1
Qualifications: A levels/AS levels or equivalent 0.3 0.6 2.2 0.6 0.3 0.1 0.9 0.1 -0.2 0.8 0.8 0.7 1.5 0.7 1.0
Serious illness, injury or assault of a close relative in last 2 years 0.5 0.5 3.3 -0.0 0.9 -0.3 -0.1 0.8 1.8 0.3 -0.0 0.8 0.3 -0.7 0.5
Mouth/teeth dental problems: Dentures 0.2 0.4 1.3 -0.3 0.2 -0.8 -1.1 0.7 0.3 -0.8 -0.9 0.2 -0.3 0.0 0.3
Asthma 0.1 0.2 0.9 0.2 0.8 -0.0 -0.4 -0.0 -0.2 1.0 0.2 -0.0 -0.2 0.7 -0.4
Medication: Ibuprofen (e.g. Nurofen) 0.3 0.3 0.7 -0.1 -0.6 -0.1 0.8 -0.2 0.7 0.7 0.5 0.8 0.5 -0.2 0.9
Medication: Cholesterol lowering 0.3 0.4 1.4 1.2 -0.2 0.6 -0.9 0.0 0.5 0.3 0.9 0.6 0.6 -0.3 0.4
Depression (self-reported) 1.8 2.2 7.4 1.7 2.7 1.1 1.3 0.1 1.0 2.0 2.0 0.8 1.6 1.0 0.5
Medication: Lansoprazole 0.4 0.5 1.7 0.8 -0.1 0.8 -1.3 -0.4 -0.8 0.1 1.0 -0.7 0.3 -0.1 -0.4
Prospective memory result 2.3 2.9 7.2 1.4 1.1 0.5 0.5 1.0 0.8 0.9 2.2 2.2 2.6 2.7 2.1
Lung cancer (father) 1.3 1.5 4.0 -1.2 -0.4 -0.7 -2.0 -0.6 -0.2 -2.0 -1.2 -1.2 -1.5 -1.2 -1.1
Illnesses of mother 0.2 0.3 1.3 -0.7 0.0 -1.1 0.7 0.1 -0.5 0.6 -0.5 -0.0 0.3 0.0 0.4
Forced expiratory volume in 1-second (FEV1), Best measure 0.4 1.2 3.1 -1.1 0.4 -1.7 1.0 1.4 1.1 0.8 -1.8 0.6 -0.9 -1.3 -0.0
Pulse wave Arterial Stiffness index 0.9 1.1 2.0 -1.4 -0.9 -0.1 -0.9 -1.1 -0.4 -1.2 -0.6 -1.0 -1.3 -1.4 -1.1
Impedance of arm (left) 2.8 12.8 48.2 1.5 3.3 -0.8 4.7 4.4 3.0 6.9 0.9 3.7 3.1 3.1 2.6
Arm fat mass (right) 0.1 0.3 1.8 0.8 -0.6 0.6 -1.3 0.1 0.7 0.0 0.1 -0.0 0.2 -0.1 0.2
Trunk predicted mass 0.4 2.3 6.9 -0.2 -2.6 0.3 -2.6 -1.4 -0.9 -2.6 -0.5 -1.0 -1.1 -1.1 -0.4
Standing height 0.5 4.8 17.8 2.3 -0.6 0.6 1.2 2.0 1.7 4.2 1.7 2.4 2.4 2.3 2.2
Length of working week for main job 0.3 0.3 1.1 1.0 -0.2 0.1 -0.2 0.7 0.8 -0.7 0.2 0.6 0.5 0.2 0.6
Exposure to tobacco smoke at home 1.3 1.5 5.1 0.2 0.3 0.5 0.3 -0.2 -1.3 0.6 -1.0 -1.5 -2.1 -1.6 -2.3
Breastfed as a baby 1.4 1.7 5.0 -0.9 0.3 -1.4 0.3 1.1 0.6 -0.7 0.3 1.0 2.2 2.2 2.2
Tense / ‘highly strung’ 4.8 8.0 26.3 3.9 -1.1 2.7 -0.8 -2.8 -0.1 0.4 5.1 1.9 3.6 3.7 2.6
Seen doctor (GP) for nerves, anxiety, tension or depression 3.2 4.8 16.5 3.0 0.5 1.9 0.4 -1.3 0.8 0.8 4.1 1.8 3.2 2.7 2.2
Hair/balding pattern: Pattern 4 0.1 0.2 0.6 0.6 -0.8 0.4 0.3 0.1 -0.4 0.5 -0.2 -0.2 -0.6 0.0 -0.6
Birth weight of first child 0.2 0.4 1.7 0.1 -1.3 -0.6 -0.1 -0.4 1.1 -0.5 0.2 0.7 0.0 0.3 0.7
Peak expiratory flow (PEF) 0.2 0.4 1.5 -0.4 -0.6 -0.0 1.2 -0.3 -0.4 0.6 -0.7 -0.3 -0.7 -1.2 -0.3
Pulse wave reflection index 0.7 0.9 2.0 -1.2 0.0 -0.5 -0.9 -0.7 -0.7 -1.1 -0.9 -0.7 -1.4 -1.2 -1.2
Ever highly irritable/argumentative for 2 days 0.5 0.6 1.3 0.9 -0.3 0.2 -0.1 0.6 1.0 0.5 0.8 1.0 1.0 1.0 1.1
Loud music exposure frequency 1.4 1.5 4.1 1.0 2.0 0.5 0.1 1.8 1.9 1.6 0.2 1.3 0.8 0.3 0.8
Qualifications: O levels/GCSEs or equivalent 0.4 0.6 1.7 0.5 -0.6 -0.1 0.1 -1.1 -0.5 -0.1 1.0 0.7 1.3 0.9 1.0
Mouth/teeth dental problems: Bleeding gums 0.1 0.1 0.4 0.4 0.3 -0.2 0.0 0.6 -0.1 0.2 0.3 0.2 -0.1 -0.1 -0.2
Blood clot in the leg (DVT) 0.2 0.3 1.0 0.5 1.0 0.4 -0.7 -0.0 -0.7 0.4 -0.1 0.2 -0.7 0.2 -0.6
Medication: Paracetamol 0.2 0.4 2.1 0.2 -0.7 0.7 -0.6 -0.7 -0.0 -1.4 0.5 0.4 -0.5 -0.4 0.0
Headache pain in last month 0.7 1.2 3.6 1.1 -0.4 1.1 0.3 -1.5 -0.5 -1.9 1.5 0.4 1.0 1.0 0.6
Medication for cholesterol, blood pressure or diabetes 0.2 0.3 1.0 -0.5 0.0 -0.5 1.0 0.4 0.5 -0.4 -0.5 -0.1 0.1 0.8 0.1
Glaucoma (self-reported) 1.3 1.6 3.1 -1.8 -0.5 -1.5 -1.8 -1.3 -0.4 -1.6 -1.4 -0.8 -1.5 -0.5 -0.6
Gout (self-reported) 0.1 0.2 0.5 -0.7 0.2 -0.3 0.2 0.6 -0.2 -0.1 -0.4 0.4 0.1 -0.2 0.6
Hypothyroidism/myxoedema (self-reported) 0.6 1.1 4.2 1.5 1.4 1.5 0.5 0.5 0.1 2.1 0.6 -0.4 0.1 -0.7 -1.0
Medication: Amlodipine 0.5 0.7 1.9 -0.9 -0.7 -0.6 -1.2 0.1 -0.5 -1.4 -0.4 0.9 0.5 0.6 1.4
Medication: Ventolin 100micrograms inhaler 1.0 1.3 5.9 -0.5 -0.5 0.3 -2.4 -1.7 0.2 -0.1 -0.3 -1.3 -1.2 -1.2 -1.2
Birth weight 2.2 4.7 13.2 -2.4 -0.9 -0.9 -0.7 -0.5 -1.2 -1.5 -3.0 -2.3 -3.6 -3.1 -2.7
Chronic bronchitis/emphysema (mother) 0.1 0.2 0.5 0.7 0.3 0.4 0.1 0.1 0.2 0.4 0.5 0.5 0.5 0.3 0.2
High blood pressure (siblings) 1.7 2.5 7.5 -0.1 -0.8 0.6 -2.7 -0.6 -1.4 -1.6 -1.0 -2.2 -2.0 -1.5 -2.2
Forced vital capacity (FVC), Best measure 0.6 2.1 5.8 -0.7 1.3 -1.7 1.1 2.4 1.8 1.9 -1.8 0.9 -0.8 -1.3 -0.2
Body fat percentage 0.3 1.2 5.5 1.6 0.8 0.9 -0.0 1.0 0.8 2.3 0.7 0.7 1.0 0.9 0.5
Leg fat percentage (right) 0.1 0.5 2.6 1.2 0.0 1.1 -1.6 -0.1 -0.2 0.3 0.4 -0.3 0.0 0.2 -0.2
Arm fat-free mass (right) 0.5 2.7 7.7 0.2 -2.6 0.9 -2.6 -2.0 -1.2 -2.8 0.0 -1.5 -1.0 -1.1 -0.7
Exposure to tobacco smoke outside home 0.7 0.9 3.5 -0.5 -1.9 -0.5 -1.5 -0.5 0.4 -1.3 0.4 0.7 -0.4 -1.0 0.8
Comparative body size at age 10 2.8 7.7 24.5 -4.0 -1.2 -2.3 -3.1 -0.4 -1.3 -4.9 -3.4 -1.7 -3.0 -2.9 -1.1
Number of full brothers 0.1 0.2 0.6 0.1 0.2 0.0 0.5 0.8 0.4 0.8 0.0 0.0 0.1 0.4 -0.1
Worry too long after embarrassment 0.3 0.5 1.6 -0.0 -1.0 0.2 -0.9 -1.3 -0.3 -1.0 -0.1 -0.4 -0.9 -0.6 -0.5
Seen a psychiatrist for nerves, anxiety, tension or depression 6.4 8.2 24.6 4.3 0.7 3.3 1.4 -1.1 1.2 3.8 5.0 1.6 3.3 3.1 1.6
Wheeze or whistling in the chest in last year 0.9 1.6 3.1 0.8 -0.4 1.3 -1.8 -1.5 -1.0 0.1 0.7 -1.7 -0.9 -1.7 -1.7
Number of children fathered 0.6 0.6 1.5 0.3 0.9 -0.4 0.3 1.2 1.0 0.4 -0.0 1.1 0.8 1.0 0.8
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.4 1.8 0.2 -0.2 0.8 1.3 -1.0 -0.4 -0.0 0.2 -0.8 -0.4 0.1 -1.0
Age at first live birth 0.7 1.2 3.2 1.8 -0.9 1.2 -0.2 -0.6 1.2 0.7 1.8 0.8 1.2 0.9 0.7
Pulse wave peak to peak time 1.0 1.2 2.2 1.4 0.8 0.2 1.0 1.3 0.4 1.4 0.6 1.0 1.3 1.5 1.1
Health satisfaction 1.1 1.4 7.2 0.0 -1.6 0.3 -2.7 -1.0 0.8 -2.3 0.6 -0.0 -0.1 -0.3 0.4
Shortness of breath walking on level ground 0.4 0.5 1.4 0.5 -0.6 0.2 -1.2 0.1 0.3 0.3 1.1 0.8 1.0 0.3 1.2
Qualifications: College or University degree 1.0 3.1 6.1 -2.2 -1.0 -1.0 0.1 -0.8 -2.0 -1.4 -2.5 -2.1 -2.4 -1.8 -2.2
Eye problems/disorders: None of the above 0.5 0.6 2.4 0.1 0.8 0.1 1.5 0.8 -0.7 1.5 -0.4 -0.4 0.1 -0.2 -0.7
Mouth/teeth dental problems: Loose teeth 0.7 0.8 2.2 1.1 -0.7 1.2 -1.5 -0.6 -0.7 -0.8 1.4 -0.0 0.5 0.4 0.3
Emphysema/chronic bronchitis 1.8 2.1 5.2 0.9 -1.5 1.3 -2.3 -2.2 -1.4 -0.7 0.4 -1.5 -1.1 -1.3 -1.6
Medication for pain relief, constipation, heartburn 0.6 1.0 4.9 -0.3 2.2 -0.3 1.2 1.2 0.7 1.5 -0.6 -0.8 0.3 0.2 -0.7
Neck or shoulder pain in last month 0.4 0.5 2.5 -0.3 1.6 -0.4 -0.1 1.1 -0.4 -0.0 0.1 0.7 0.8 0.7 0.7
Medication: Blood pressure 0.6 1.1 3.6 1.4 -0.8 1.7 -0.9 -1.4 -0.5 0.6 1.9 0.2 0.7 -0.2 0.2
Angina (self-reported) 1.4 1.8 5.8 2.4 -1.4 2.0 -0.2 0.1 0.5 1.6 2.0 1.1 1.0 0.8 0.5
Migraine (self-reported) 2.4 2.9 9.7 1.5 1.8 0.9 3.1 0.7 0.9 1.8 1.8 0.8 2.5 2.0 0.7
Medication: Ibuprofen 0.3 0.4 1.3 -0.5 -0.8 -0.6 0.5 0.4 1.1 0.4 0.1 0.8 0.4 -0.2 0.8
Medication: Allopurinol 1.6 2.2 5.2 -0.1 2.3 -0.8 1.2 2.1 0.6 1.4 -0.1 2.2 1.5 1.3 1.9
Medication: Omeprazole 1.1 1.3 5.3 1.6 -0.3 0.6 0.0 0.7 0.1 0.6 1.4 1.1 1.6 2.3 1.2
Medication: Seretide 50 evohaler 0.3 0.4 1.1 0.5 -1.0 0.5 -0.2 -0.1 0.6 1.0 0.7 0.2 0.5 0.6 0.1
Mean time to correctly identify matches 1.0 1.9 4.8 -1.6 2.2 -0.9 1.4 1.9 -1.2 1.2 -1.3 -0.1 -0.7 -1.8 -0.7
Heart disease (mother) 0.4 0.5 2.0 0.8 0.8 0.9 -1.4 -0.8 -0.2 -0.8 0.3 -0.2 -0.4 0.5 -0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.8 1.0 2.0 0.2 -1.4 0.8 -0.6 -1.4 -1.4 -1.0 0.0 -1.3 -1.0 -0.5 -1.2
Whole body fat mass 0.1 0.4 1.5 1.1 -0.1 0.7 -0.9 0.5 0.6 1.2 0.4 0.3 0.4 0.4 0.3
Leg fat mass (right) 0.1 0.4 2.2 1.1 -0.3 1.0 -1.5 -0.2 0.1 0.1 0.4 -0.2 0.2 0.0 0.0
Arm predicted mass (right) 0.6 2.9 7.3 0.4 -2.5 1.1 -2.7 -2.2 -1.6 -2.7 0.1 -1.6 -1.0 -1.1 -0.8
Pulse rate, automated reading 2.3 7.3 16.2 -1.1 -1.8 1.1 -2.8 -3.4 -3.4 -2.5 -0.7 -4.0 -2.9 -2.9 -3.4
Alcohol intake frequency. 0.2 0.5 2.4 1.0 -1.0 0.8 -1.6 -0.3 -0.6 0.2 0.6 -0.1 -0.1 -0.5 0.1
Comparative height size at age 10 0.5 2.7 7.3 2.6 -2.1 1.6 -0.9 0.1 1.0 2.7 1.8 1.2 1.1 1.5 0.9
Number of full sisters 1.1 1.3 4.7 0.9 1.6 0.3 2.2 1.5 0.4 2.0 0.4 0.1 0.7 0.8 -0.1
Suffer from ‘nerves’ 1.5 2.4 9.4 3.1 -0.5 2.4 -1.1 -1.7 -0.3 0.7 2.7 -0.5 0.6 0.4 -0.6
Overall health rating 1.0 2.2 13.4 1.0 -1.6 0.8 -3.7 -0.7 1.2 -1.1 1.8 0.6 0.6 0.4 0.9
Chest pain or discomfort 1.3 1.8 5.4 2.2 -0.0 1.9 -2.3 -0.9 0.2 -0.1 2.0 0.9 1.2 0.0 0.8
Had major operations 0.7 0.8 3.0 1.2 0.8 0.7 0.1 0.5 0.7 1.1 1.0 0.6 0.7 1.7 0.3
Age at last live birth 1.2 1.7 5.1 0.6 -1.1 -0.1 0.0 0.4 1.5 0.5 1.0 2.1 1.6 1.8 2.3
Family relationship satisfaction 0.5 0.6 1.4 -0.9 -0.1 -0.3 -0.9 0.1 0.7 -0.5 -0.9 -0.8 -1.2 -1.0 -0.9
Leg pain on walking 0.8 1.0 4.5 -0.8 0.7 -0.6 -2.1 0.4 -0.2 -1.8 -0.8 -0.4 -0.6 -1.0 -0.3
Qualifications: NVQ or HND or HNC or equivalent 0.1 0.1 0.3 0.2 -0.5 0.1 0.0 0.3 0.3 0.3 0.2 0.3 -0.3 -0.5 0.2
Commuting to job workplace: Car/motor vehicle 1.5 1.7 6.5 2.4 0.6 2.5 -0.3 -1.0 -0.0 1.4 1.9 -0.6 0.7 -0.4 -0.7
Illness, injury, bereavement, stress in last 2 years 2.4 2.9 8.1 -0.3 -0.4 1.0 -1.4 -2.1 -2.8 -1.3 -1.0 -2.2 -2.2 -1.1 -2.3
Medication: Aspirin 1.4 1.8 7.0 1.8 -2.6 1.1 -0.9 -1.5 -0.6 -0.7 1.8 0.8 0.9 0.8 0.9
Supplements: Vitamin C 0.8 1.0 5.1 0.4 -2.2 1.1 -0.5 -1.5 -0.7 -0.6 1.1 -0.4 0.3 0.4 0.2
Knee pain experienced in last month 0.5 0.8 2.5 1.4 0.5 1.6 -1.5 -0.2 -0.1 -1.1 0.8 0.5 0.3 0.1 0.4
Hypertension (Self-reported) 1.0 2.7 7.5 1.3 -1.5 2.7 -1.1 -1.9 -2.4 -0.0 1.3 -2.0 -0.6 -1.4 -1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.8 0.9 2.0 0.7 1.0 -0.0 0.8 0.7 0.7 1.2 0.6 1.1 1.2 1.4 0.9
Illnesses of father: Heart disease 0.5 0.7 3.7 1.9 -0.5 1.4 0.2 -0.6 0.1 0.3 1.3 -0.0 0.0 0.6 -0.4
Illnesses of siblings: Diabetes 3.3 4.0 10.9 -2.4 -1.5 -1.8 -2.0 1.3 -0.8 -2.1 -3.3 -1.4 -2.9 -1.6 -1.6
Smoking status: Previous 1.1 1.6 4.7 -0.3 -1.1 0.5 0.1 -0.9 -2.0 -0.1 -0.8 -1.5 -2.2 -1.0 -2.2
Forced expiratory volume in 1-second (FEV1), predicted 0.6 1.3 4.5 0.2 0.9 -1.0 0.2 2.1 1.3 1.7 -0.5 1.4 0.7 0.8 1.1
Whole body fat-free mass 0.3 2.0 6.7 -0.0 -2.6 0.4 -2.5 -1.3 -0.7 -2.3 -0.3 -0.9 -0.9 -1.1 -0.3
Leg fat-free mass (right) 0.2 0.9 3.8 0.2 -1.9 0.2 -1.9 -0.8 -0.1 -1.5 -0.0 -0.4 -0.3 -0.7 0.2
Arm fat percentage (left) 0.1 0.3 1.1 0.5 0.2 0.2 -0.6 0.8 1.1 0.7 -0.1 0.4 0.3 0.2 0.4
Average weekly red wine intake 1.3 2.0 5.3 1.7 -0.2 1.7 1.3 -0.9 0.5 1.0 2.3 0.1 2.2 1.8 0.9
Handedness (chirality/laterality): Left-handed 1.7 2.0 4.6 0.6 -0.6 -0.0 0.7 0.9 2.0 0.3 1.5 1.8 2.0 2.1 2.0
Mood swings 2.1 3.8 13.9 2.2 0.7 1.7 0.5 -1.1 1.8 0.3 3.7 1.6 2.7 2.1 2.2
Loneliness, isolation 0.5 0.8 2.4 0.9 -0.4 0.2 -1.2 0.0 1.6 0.3 1.4 0.5 1.0 0.6 0.8
Long-standing illness, disability or infirmity 0.7 1.1 8.2 1.3 -0.4 1.3 -2.9 -0.3 0.4 0.4 1.1 -0.2 -0.2 -0.2 -0.6
Ever had bowel cancer screening 1.4 1.6 3.8 1.7 -1.6 1.1 -0.6 -0.7 0.1 0.4 1.9 0.9 1.4 1.9 1.3
Diabetes diagnosed by doctor 0.5 0.9 2.9 1.3 -1.0 1.6 -1.7 -0.5 0.5 0.4 1.1 -0.1 -0.3 -0.4 -0.3
Ever had stillbirth, spontaneous miscarriage or termination 0.6 0.6 2.2 -0.2 -1.3 0.2 -1.5 -0.0 -0.8 -0.4 -0.5 -0.9 -0.9 -0.6 -0.9
Friendships satisfaction 1.9 2.3 7.1 -1.9 0.1 -1.1 -0.9 0.4 0.2 -1.2 -2.5 -1.2 -2.7 -1.8 -1.6
Qualifications: nursing, teaching 0.4 0.7 1.8 -0.0 0.6 -0.7 1.1 0.6 -0.7 0.1 0.1 0.9 1.3 1.2 1.0
Commuting to job workplace: Walk 0.8 0.9 2.8 -1.2 0.8 -1.7 0.6 0.4 0.1 -1.4 -0.3 1.3 0.2 0.5 1.2
Eye problems/disorders: Cataract 0.7 0.8 5.5 -0.0 -0.9 0.1 -2.3 -0.6 -0.1 -1.5 0.3 -0.1 -0.6 -0.2 -0.2
Mouth/teeth dental problems: Mouth ulcers 0.1 0.2 0.6 -0.1 0.3 -0.2 -0.6 0.4 0.8 0.3 -0.4 0.5 -0.2 0.1 0.4
Medication for cholesterol 1.3 1.9 6.1 0.1 1.7 -1.1 -0.1 1.3 2.5 1.1 0.2 1.9 1.4 1.5 1.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.1 1.3 3.4 1.0 -1.3 1.8 -0.2 -0.6 -1.5 0.4 0.3 -1.0 -1.6 -0.8 -1.6
Back pain experienced in last month 1.9 2.8 8.3 -1.8 -0.9 -0.3 -1.8 0.1 -1.3 -1.5 -1.9 -1.6 -2.9 -2.1 -2.0
Mineral and other dietary supplements 1.6 2.1 5.1 -2.0 0.0 -1.0 -0.4 -0.0 -1.1 -1.5 -2.3 -1.5 -1.9 -2.0 -1.5
Breast cancer (self-reported) 1.4 1.7 5.5 1.8 -0.0 2.4 1.0 -1.8 -0.9 0.9 1.7 -1.0 0.3 -0.1 -1.2
Asthma (self-reported) 0.1 0.3 1.1 0.4 0.8 0.0 -0.4 0.0 0.3 1.0 0.4 0.2 0.1 0.8 -0.1
Osteoporosis (self-reported) 1.4 1.8 4.4 2.0 -1.3 1.8 -1.0 -2.0 0.5 -0.3 2.1 0.4 1.1 1.0 0.6
Osteoarthritis (self-reported) 1.1 1.4 7.2 1.7 -0.5 1.5 -2.7 -1.3 0.8 -1.1 0.9 0.2 -0.0 0.6 0.0
Medication: Aspirin 1.5 2.0 6.8 2.0 -2.6 1.6 -0.9 -1.6 -1.0 -0.6 2.0 0.4 0.9 0.4 0.6
Medication: Gliclazide 0.6 0.7 3.5 0.3 0.3 0.2 0.3 1.2 1.9 1.3 0.6 0.2 0.7 -0.0 0.3
Illnesses of father: None of the above (group 1) 0.4 0.5 1.6 -0.2 0.7 0.0 0.4 0.9 0.2 0.8 0.1 0.6 1.3 0.4 1.1
Smoking status: Current 0.4 0.6 1.4 1.1 0.1 1.2 -1.1 0.5 0.7 0.5 1.2 0.5 0.7 -0.1 0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.8 2.9 -0.7 -0.7 -0.6 0.5 -0.1 0.5 -0.2 -1.2 -0.7 -1.3 -1.7 -1.0
Whole body water mass 0.3 1.8 6.7 0.1 -2.6 0.4 -2.5 -1.2 -0.6 -2.3 -0.1 -0.8 -0.7 -0.9 -0.1
Leg predicted mass (right) 0.2 1.0 3.9 0.1 -2.0 0.2 -1.9 -0.8 -0.1 -1.5 -0.1 -0.4 -0.3 -0.7 0.2
Arm fat mass (left) 0.1 0.4 1.9 0.8 -0.8 0.6 -1.4 0.1 0.9 -0.1 0.2 0.2 0.3 0.1 0.4
Number of self-reported non-cancer illnesses 1.6 2.8 11.2 1.5 -0.6 2.1 -3.3 -2.3 -1.9 -0.0 1.1 -1.5 -0.9 -0.3 -1.6
Average weekly champagne plus white wine intake 1.7 2.3 5.2 1.7 -0.3 1.4 2.0 -0.3 -0.5 1.1 1.9 1.5 2.3 1.7 1.6
Miserableness 0.8 1.4 5.2 0.9 -0.7 0.7 -2.3 -2.2 -0.1 -1.2 1.5 0.1 0.7 0.0 0.8
Guilty feelings 1.4 2.1 6.1 2.0 -1.5 2.0 -1.3 -2.5 -0.4 -0.2 2.5 -0.4 0.9 0.5 0.2
Wears glasses or contact lenses 0.4 0.4 1.7 -0.4 -0.6 0.3 -1.3 -0.6 -1.0 -0.6 -0.2 -0.1 -1.1 -0.3 -0.3
Ever taken oral contraceptive pill 1.5 1.7 3.4 -1.5 -1.6 -0.8 -0.6 0.2 -1.6 -0.9 -1.4 -0.9 -1.8 -1.8 -1.2
Hearing aid user 0.6 0.7 2.2 -0.9 -0.7 -0.4 -0.4 -1.0 -1.2 -1.5 -0.7 -0.7 -0.9 -0.2 -0.5
Mother’s age at death 1.1 1.3 3.8 -1.5 -2.0 -0.9 -0.1 -0.3 -1.0 -1.8 -1.1 -0.5 -1.4 -1.1 -0.3
Financial situation satisfaction 0.9 1.1 4.3 -1.8 0.8 -2.1 0.0 0.9 1.6 -0.3 -1.1 0.5 -0.3 -0.1 0.6
Tinnitus: Yes, now most or all of the time 0.7 0.8 2.0 1.4 1.3 0.7 0.7 -0.1 0.3 1.4 1.1 0.7 1.0 0.5 0.5
Commuting to job workplace: Public transport 0.2 0.2 1.4 -0.3 -1.2 -0.5 -0.4 -0.3 -0.1 -0.6 -0.4 0.2 -0.6 -0.1 -0.1
Eye problems/disorders: Glaucoma 0.4 0.5 2.2 -1.3 0.1 -1.5 -0.5 -0.3 0.4 -0.7 -0.9 0.2 -0.4 0.2 0.5
Medication: Blood pressure 0.9 1.8 5.4 0.8 -1.6 2.1 -0.3 -1.6 -2.3 -0.5 1.0 -1.6 -0.6 -0.6 -1.1
Pain type(s) experienced in last month: Hip pain 2.4 3.1 6.2 0.9 -1.0 1.4 -2.5 -1.6 -1.4 -1.4 -0.2 -2.3 -2.3 -2.0 -2.5
Supplements: Fish oil (including cod liver oil) 0.6 0.7 2.2 1.2 -0.2 0.6 -0.1 0.0 1.2 1.5 1.2 0.8 0.7 0.5 0.6
High cholesterol (Self-reported) 0.2 0.4 2.1 1.4 0.4 1.0 -0.6 -0.4 -0.2 0.4 0.9 0.4 0.3 0.3 0.1
Medication: Bendroflumethiazide 2.2 3.3 8.9 -0.4 -2.8 0.7 -1.3 -2.1 -3.0 -2.5 0.1 -1.7 -1.4 -1.9 -1.3
Medication: Paracetamol 0.4 0.7 2.0 0.7 -0.2 1.1 -0.4 -0.8 -0.0 -1.1 1.4 1.0 0.6 0.3 0.9
Medication: Lisinopril 0.3 0.4 1.9 -0.1 0.5 -0.1 0.3 0.6 1.4 1.3 0.2 0.3 0.6 -0.0 0.5
Medication: Atorvastatin 0.3 0.4 1.1 -1.0 -1.1 -0.7 -0.7 -0.2 0.1 -0.9 -0.4 -0.4 0.1 -0.5 0.3
Illnesses of father: High blood pressure 0.2 0.3 1.3 0.3 0.6 -0.3 -0.6 -0.1 1.2 0.7 -0.2 -0.1 -0.5 -0.5 -0.4
Alcohol drinker status: Never 0.4 0.5 1.4 0.0 0.3 0.5 -0.7 -1.2 -0.6 -1.1 0.4 0.2 0.7 -0.1 0.9
Ever smoked 0.3 0.5 1.8 0.1 -0.9 0.7 -0.6 -0.2 -0.5 -0.1 -0.6 -0.8 -1.3 -0.6 -1.3
Basal metabolic rate 0.2 1.3 5.3 0.3 -2.2 0.5 -2.3 -1.0 -0.3 -1.8 -0.1 -0.6 -0.6 -0.8 -0.1
Leg fat percentage (left) 0.1 0.4 1.4 1.1 0.4 0.8 -1.2 0.1 -0.2 0.7 0.4 -0.2 0.2 0.2 -0.1
Arm fat-free mass (left) 0.6 2.8 8.4 0.5 -2.7 1.1 -2.9 -2.0 -1.1 -2.6 0.2 -1.4 -0.9 -1.2 -0.6
Number of operations (self-reported) 0.7 1.1 2.4 -0.1 -1.4 0.8 -1.3 -1.6 -0.7 -1.1 -0.2 -1.0 -1.4 -0.4 -1.3
Average weekly beer plus cider intake 0.3 0.4 4.0 0.2 2.0 -0.3 0.1 0.4 0.6 0.4 -0.3 -0.2 -0.2 0.3 -0.3
Irritability 1.8 3.1 10.0 2.2 0.3 1.3 -0.6 -1.8 1.9 0.1 3.2 1.4 2.4 1.3 1.9
Risk taking 0.5 0.7 2.6 0.3 -0.6 1.3 0.7 -1.4 -1.6 0.1 1.2 -0.5 0.3 0.3 -0.2
Ever had prostate specific antigen (PSA) test 1.7 2.0 5.4 1.0 -0.2 -0.3 0.4 1.1 1.8 1.7 0.7 2.3 1.4 1.9 2.0
Fractured/broken bones in last 5 years 0.7 0.9 2.8 1.7 0.6 1.2 -0.1 -0.1 -0.1 1.5 1.5 0.3 0.8 1.0 -0.0
Age started oral contraceptive pill 0.5 0.6 1.4 -0.3 -0.8 0.3 -0.2 -0.5 -1.0 -0.8 -0.2 -1.0 -0.9 -1.0 -1.2
Diastolic blood pressure, automated reading 1.6 5.1 14.0 -0.6 -0.6 1.0 -1.8 -1.7 -2.1 -1.9 -1.3 -3.7 -2.8 -3.0 -3.6
Ever depressed for a whole week 1.0 1.2 3.2 1.3 0.8 0.9 1.1 0.2 0.8 1.3 1.7 0.8 1.8 0.6 1.0
Unable to work because of sickness or disability 0.5 0.7 1.4 0.7 -0.6 1.0 -0.5 -0.8 -1.2 -0.6 1.0 -0.7 -0.5 -0.4 -1.1
Commuting to job workplace: Cycle 1.4 1.7 4.4 0.3 1.6 -0.3 2.1 1.4 0.8 1.1 0.3 1.6 1.2 1.8 1.4
Myopia 0.5 0.7 2.2 1.4 -0.0 0.3 -1.5 0.1 -0.4 1.4 0.4 0.4 -0.2 1.4 -0.3
Vascular/heart problems diagnosed by doctor 1.1 2.9 7.3 -1.4 1.6 -2.7 1.4 2.4 2.6 0.4 -1.7 1.7 0.3 0.8 1.3
Cholesterol lowering medication 0.3 0.5 1.5 0.6 -1.0 0.7 -0.7 -0.8 -1.2 -0.2 0.1 -0.7 -0.7 -0.2 -0.9
Medication: Omeprazole (e.g. Zanprol) 0.9 1.1 4.7 1.5 -0.3 0.8 -0.5 -0.0 -0.3 -0.1 1.4 0.7 1.3 2.2 1.0
Pain experienced in last month 0.8 1.3 2.7 -0.6 0.4 -1.3 1.6 1.6 0.9 1.6 -0.3 0.9 1.1 1.0 1.2
Supplements: Calcium 1.3 1.5 5.0 1.9 -1.2 2.2 0.4 -1.4 -1.0 0.6 1.5 -0.5 0.5 1.2 -0.5
Basal cell carcinoma (self-reported) 1.1 1.3 2.4 0.8 0.2 0.5 1.5 0.7 1.5 1.0 1.1 1.3 1.4 1.5 1.4
Heart attack/myocardial infarction (self-reported) 1.0 1.3 4.6 1.4 -0.7 1.4 -1.1 -1.1 0.3 -0.3 2.1 0.8 1.3 1.0 0.9
Deep venous thrombosis (DVT) (self-reported) 0.3 0.3 1.3 -0.1 1.1 -0.0 -0.7 0.3 -0.8 0.0 -0.7 0.2 -0.9 -0.1 -0.6
Heart disease (siblings) 2.5 3.0 9.4 -1.3 -0.3 0.1 -1.2 -0.6 -1.0 -0.8 -2.4 -2.4 -3.1 -1.9 -2.6
Alcohol drinker status: Previous 0.9 1.0 3.2 1.4 -0.5 0.4 0.5 0.6 -0.5 1.8 1.4 0.4 1.4 1.2 0.7
Pack years of smoking 0.3 0.5 2.6 0.0 -1.3 0.5 -1.6 -0.7 0.5 -0.7 0.6 -0.1 0.0 -0.2 0.4
Impedance of whole body 2.3 11.5 49.5 1.8 3.7 -0.1 4.6 3.9 2.0 7.0 1.2 3.0 2.9 2.9 2.0
Leg fat mass (left) 0.1 0.4 2.0 1.1 -0.2 1.0 -1.4 -0.3 -0.1 0.2 0.4 -0.4 0.2 -0.2 -0.1
Arm predicted mass (left) 0.5 2.5 8.4 0.1 -2.6 0.7 -2.9 -1.6 -1.0 -2.5 -0.2 -1.3 -1.1 -1.2 -0.7