Best TWAS P=8.29e-10 · Best GWAS P=3.75e-09 conditioned to 0.102
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | PRPS1P2 | 0.06 | 0.06 | enet | 6 | 0.05 | 9.2e-05 | -5.5 | -5.5 | 3.0e-08 | 0.77 | 0.04 | 0.96 | FALSE |
| 2 | GTEx | Breast Mammary Tissue (Male) | PPP6C | 0.12 | 0.03 | enet | 12 | 0.03 | 6.5e-02 | -5.6 | 5.6 | 2.3e-08 | -0.76 | 0.04 | 0.56 | FALSE |
| 3 | GTEx | Breast Mammary Tissue (Female) | PPP6C | 0.14 | 0.04 | lasso | 4 | 0.04 | 3.1e-02 | -5.5 | 5.5 | 3.7e-08 | -0.86 | 0.05 | 0.88 | FALSE |
| 4 | GTEx | Cells Transformed fibroblasts | PRPS1P2 | 0.09 | 0.11 | enet | 8 | 0.13 | 9.6e-10 | -5.7 | -6.1 | 8.3e-10 | 0.80 | 0.03 | 0.97 | TRUE |
| 5 | GTEx | Colon Transverse | PRPS1P2 | 0.11 | 0.10 | lasso | 1 | 0.08 | 1.8e-04 | -5.7 | -5.7 | 1.1e-08 | 0.82 | 0.03 | 0.96 | FALSE |
| 6 | GTEx | Esophagus Mucosa | PPP6C | 0.07 | 0.07 | enet | 21 | 0.08 | 7.1e-06 | -5.9 | 5.8 | 6.6e-09 | -0.92 | 0.03 | 0.97 | FALSE |
| 7 | GTEx | Esophagus Mucosa | PRPS1P2 | 0.07 | 0.08 | lasso | 3 | 0.07 | 1.5e-05 | -5.5 | -5.3 | 9.5e-08 | 0.75 | 0.04 | 0.96 | FALSE |
| 8 | GTEx | Muscle Skeletal | PPP6C | 0.03 | 0.03 | enet | 6 | 0.01 | 3.0e-02 | -5.7 | 5.1 | 3.1e-07 | -0.78 | 0.04 | 0.94 | FALSE |
| 9 | GTEx | Nerve Tibial | GAPVD1 | 0.17 | 0.08 | lasso | 10 | 0.10 | 9.3e-08 | -5.9 | 6.0 | 2.7e-09 | -0.92 | 0.02 | 0.98 | FALSE |
| 10 | GTEx | Pancreas | PRPS1P2 | 0.16 | 0.13 | lasso | 6 | 0.12 | 8.7e-06 | -5.5 | -5.7 | 1.6e-08 | 0.79 | 0.04 | 0.96 | FALSE |
| 11 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | PPP6C | 0.07 | 0.08 | lasso | 3 | 0.09 | 5.4e-10 | -5.5 | 5.2 | 1.8e-07 | -0.78 | 0.04 | 0.96 | FALSE |
| 12 | The Cancer Genome Atlas | Brain Lower Grade Glioma | PPP6C | 0.02 | 0.02 | lasso | 2 | 0.01 | 1.5e-02 | -5.7 | 5.7 | 1.3e-08 | -0.82 | 0.02 | 0.71 | FALSE |
| 13 | The Cancer Genome Atlas | Lung Adenocarcinoma | PPP6C | 0.02 | 0.02 | lasso | 4 | 0.02 | 7.6e-04 | -5.5 | 5.7 | 1.6e-08 | -0.79 | 0.02 | 0.96 | FALSE |
| 14 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PPP6C | 0.06 | 0.08 | lasso | 7 | 0.07 | 1.8e-07 | -5.7 | 5.4 | 7.4e-08 | -0.80 | 0.02 | 0.98 | FALSE |
| 15 | The Cancer Genome Atlas | Stomach Adenocarcinoma | PPP6C | 0.05 | 0.04 | blup | 46 | 0.03 | 3.8e-03 | -5.5 | 5.3 | 8.7e-08 | -0.73 | 0.03 | 0.94 | FALSE |
| 16 | The Cancer Genome Atlas | Thyroid Carcinoma | PPP6C | 0.08 | 0.13 | enet | 9 | 0.13 | 5.5e-13 | -5.7 | 5.4 | 7.7e-08 | -0.80 | 0.02 | 0.98 | FALSE |