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chr8:8,092,025-11,891,593

Best TWAS P=5.44e-13 · Best GWAS P=3.79e-13 conditioned to 0.0188

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	FAM167A	0.09	0.09	lasso	6	0.13	1.4e-15	3.7	5.9	3.7e-09	-0.71	0.89	0.11	FALSE
2	GTEx	Adipose Subcutaneous	AF131215.2	0.24	0.15	lasso	7	0.14	3.5e-11	5.3	-5.7	1.4e-08	0.86	0.13	0.87	FALSE
3	GTEx	Adipose Visceral Omentum	FAM86B3P	0.23	0.07	enet	20	0.14	6.4e-08	-6.6	-5.7	9.4e-09	0.61	0.01	0.99	FALSE
4	GTEx	Adipose Visceral Omentum	AF131215.2	0.12	0.08	lasso	6	0.06	4.6e-04	-5.7	-6.2	5.2e-10	0.87	0.15	0.82	FALSE
5	GTEx	Adipose Visceral Omentum	AF131215.9	0.18	0.16	lasso	7	0.16	2.0e-08	-5.7	-6.1	8.4e-10	0.91	0.06	0.94	FALSE
6	GTEx	Adrenal Gland	AF131215.2	0.20	0.16	enet	12	0.13	2.2e-05	-6.6	-6.8	1.3e-11	0.96	0.04	0.96	FALSE
7	GTEx	Adrenal Gland	AF131215.9	0.18	0.16	lasso	10	0.18	3.5e-07	-6.6	-6.9	5.5e-12	0.94	0.02	0.98	FALSE
8	GTEx	Artery Aorta	FDFT1	0.09	0.02	lasso	4	0.03	6.1e-03	-4.6	-5.3	1.1e-07	0.65	0.16	0.42	FALSE
9	GTEx	Artery Aorta	ERI1	0.11	0.08	lasso	5	0.10	5.1e-06	-4.6	5.4	7.6e-08	-0.64	0.63	0.33	FALSE
10	GTEx	Artery Aorta	AF131215.2	0.09	0.09	lasso	7	0.08	2.0e-05	5.3	-6.4	1.2e-10	0.92	0.04	0.96	FALSE
11	GTEx	Artery Aorta	AF131215.9	0.13	0.05	lasso	6	0.07	1.3e-04	-7.3	-6.7	1.8e-11	0.95	0.01	0.99	FALSE
12	GTEx	Artery Tibial	ERI1	0.05	0.02	lasso	7	0.01	3.2e-02	-5.6	5.9	4.6e-09	-0.67	0.08	0.86	FALSE
13	GTEx	Artery Tibial	AF131215.2	0.07	0.03	enet	24	0.05	1.8e-04	5.4	-6.1	1.4e-09	0.73	0.04	0.96	FALSE
14	GTEx	Brain Cerebellar Hemisphere	FAM86B3P	0.28	0.27	lasso	8	0.28	5.4e-08	-6.8	6.4	1.3e-10	-0.69	0.01	0.99	FALSE
15	GTEx	Brain Cerebellar Hemisphere	AF131215.2	0.15	0.17	lasso	3	0.09	3.0e-03	5.4	-6.1	1.2e-09	0.81	0.16	0.49	FALSE
16	GTEx	Brain Cerebellum	FAM86B3P	0.19	0.14	lasso	5	0.16	1.8e-05	-5.2	6.0	2.0e-09	-0.70	0.03	0.96	FALSE
17	GTEx	Brain Cortex	FAM86B3P	0.14	0.05	enet	9	0.07	5.1e-03	-4.8	5.8	5.7e-09	-0.67	0.14	0.36	FALSE
18	GTEx	Brain Frontal Cortex BA9	FAM86B3P	0.16	0.13	enet	27	0.10	1.1e-03	-5.1	5.8	7.6e-09	-0.61	0.02	0.94	FALSE
19	GTEx	Breast Mammary Tissue	AF131215.2	0.16	0.15	lasso	6	0.12	1.1e-06	5.3	-5.8	6.7e-09	0.86	0.42	0.56	FALSE
20	GTEx	Breast Mammary Tissue	AF131215.9	0.10	0.10	lasso	8	0.12	8.7e-07	5.9	-6.5	8.4e-11	0.83	0.29	0.70	FALSE
21	GTEx	Breast Mammary Tissue (Male)	AF131215.2	0.31	0.08	enet	23	0.03	5.9e-02	5.3	-5.6	1.9e-08	0.74	0.12	0.20	FALSE
22	GTEx	Breast Mammary Tissue (Female)	AF131215.2	0.04	-0.01	lasso	2	0.00	4.8e-01	5.9	-5.9	3.0e-09	0.73	0.07	0.14	FALSE
23	GTEx	Cells EBV-transformed lymphocytes	AF131215.2	0.20	0.10	enet	14	0.11	1.5e-04	5.4	-6.3	2.6e-10	0.86	0.15	0.82	FALSE
24	GTEx	Cells EBV-transformed lymphocytes	AF131215.9	0.20	0.15	enet	19	0.13	5.6e-05	5.4	-5.7	1.2e-08	0.78	0.13	0.83	FALSE
25	GTEx	Cells Transformed fibroblasts	FAM86B3P	0.23	0.33	lasso	11	0.38	8.4e-30	-5.1	-6.0	2.2e-09	0.69	0.39	0.61	FALSE
26	GTEx	Colon Sigmoid	MTMR9	0.24	0.18	lasso	4	0.14	1.6e-05	6.1	-6.1	1.2e-09	0.55	0.75	0.14	FALSE
27	GTEx	Colon Sigmoid	AF131215.2	0.10	0.00	enet	7	0.02	5.0e-02	-4.9	-6.1	1.1e-09	0.81	0.11	0.60	FALSE
28	GTEx	Colon Sigmoid	AF131215.9	0.11	0.17	enet	5	0.09	4.9e-04	5.4	-5.8	5.1e-09	0.81	0.19	0.58	FALSE
29	GTEx	Colon Transverse	MTMR9	0.21	0.06	lasso	5	0.03	1.0e-02	6.0	-5.9	2.8e-09	0.48	0.34	0.17	FALSE
30	GTEx	Colon Transverse	AF131215.2	0.15	0.09	enet	32	0.07	3.1e-04	-7.3	-5.8	6.2e-09	0.79	0.01	0.99	FALSE
31	GTEx	Colon Transverse	AF131215.9	0.12	0.14	enet	18	0.12	4.0e-06	5.4	-6.2	4.8e-10	0.83	0.03	0.97	FALSE
32	GTEx	Esophagus Gastroesophageal Junction	AF131215.2	0.13	0.06	enet	10	0.11	6.4e-05	-6.1	-6.2	6.4e-10	0.85	0.13	0.77	FALSE
33	GTEx	Esophagus Mucosa	FAM86B3P	0.22	0.17	lasso	8	0.19	1.7e-12	-5.1	-5.8	8.6e-09	0.67	0.30	0.70	FALSE
34	GTEx	Esophagus Mucosa	AF131215.2	0.15	0.14	enet	15	0.18	4.3e-12	5.1	-6.0	2.1e-09	0.82	0.95	0.05	FALSE
35	GTEx	Esophagus Mucosa	AF131215.9	0.18	0.16	lasso	14	0.19	1.6e-12	-6.3	-6.7	2.9e-11	0.91	0.02	0.98	FALSE
36	GTEx	Esophagus Muscularis	ERI1	0.12	0.09	enet	13	0.08	7.7e-06	-4.5	5.7	9.6e-09	-0.68	0.17	0.83	FALSE
37	GTEx	Esophagus Muscularis	AF131215.2	0.10	0.08	lasso	5	0.09	2.3e-06	5.0	-5.7	9.5e-09	0.78	0.62	0.36	FALSE
38	GTEx	Esophagus Muscularis	AF131215.9	0.14	0.17	enet	16	0.17	1.6e-10	5.4	-6.3	2.2e-10	0.83	0.24	0.76	FALSE
39	GTEx	Heart Atrial Appendage	AF131215.2	0.39	0.13	enet	26	0.21	6.6e-10	5.0	-5.9	3.5e-09	0.77	0.56	0.44	FALSE
40	GTEx	Heart Atrial Appendage	AF131215.9	0.24	0.17	enet	26	0.18	1.3e-08	5.1	-5.9	2.7e-09	0.74	0.68	0.32	FALSE
41	GTEx	Heart Left Ventricle	AF131215.2	0.05	0.01	enet	11	0.01	1.5e-01	-5.7	-5.9	4.1e-09	0.85	0.05	0.89	FALSE
42	GTEx	Heart Left Ventricle	AF131215.9	0.07	0.10	enet	8	0.10	9.4e-06	5.4	-6.0	2.4e-09	0.85	0.08	0.90	FALSE
43	GTEx	Lung	ERI1	0.13	0.07	lasso	6	0.09	2.7e-07	5.4	5.8	8.8e-09	-0.69	0.23	0.77	FALSE
44	GTEx	Lung	AF131215.2	0.12	0.08	lasso	5	0.08	1.0e-06	5.4	-5.6	2.6e-08	0.80	0.10	0.90	FALSE
45	GTEx	Lung	AF131215.9	0.15	0.18	lasso	4	0.15	1.5e-11	5.4	-5.5	4.9e-08	0.79	0.62	0.38	FALSE
46	GTEx	Muscle Skeletal	MFHAS1	0.07	0.04	lasso	4	0.04	1.4e-04	-4.8	-6.0	1.9e-09	0.66	0.34	0.62	FALSE
47	GTEx	Nerve Tibial	AF131215.2	0.19	0.18	lasso	12	0.23	3.5e-16	5.0	-6.5	1.0e-10	0.89	0.01	0.99	FALSE
48	GTEx	Nerve Tibial	AF131215.9	0.17	0.17	lasso	4	0.18	5.0e-13	5.4	-5.5	3.2e-08	0.80	0.21	0.79	FALSE
49	GTEx	Pancreas	ERI1	0.08	0.00	enet	16	0.04	6.6e-03	-5.1	5.5	3.7e-08	-0.63	0.15	0.33	FALSE
50	GTEx	Pancreas	AF131215.2	0.16	0.16	enet	17	0.15	9.1e-07	5.4	-6.2	5.8e-10	0.87	0.03	0.97	FALSE
51	GTEx	Pancreas	AF131215.9	0.25	0.24	enet	14	0.22	1.0e-09	-7.3	-6.6	3.6e-11	0.94	0.00	1.00	FALSE
52	GTEx	Pituitary	FAM86B3P	0.13	0.15	lasso	4	0.13	3.5e-04	6.0	6.4	2.2e-10	-0.58	0.02	0.93	FALSE
53	GTEx	Prostate	AF131215.2	0.18	0.02	lasso	6	0.02	9.6e-02	-5.5	-6.8	8.8e-12	0.77	0.11	0.34	FALSE
54	GTEx	Skin Not Sun Exposed Suprapubic	AF131215.2	0.16	0.11	enet	21	0.20	3.9e-11	5.1	-6.6	3.8e-11	0.88	0.35	0.65	FALSE
55	GTEx	Skin Not Sun Exposed Suprapubic	AF131215.9	0.17	0.14	lasso	8	0.19	9.4e-11	5.4	-6.6	5.1e-11	0.87	0.09	0.91	FALSE
56	GTEx	Skin Sun Exposed Lower leg	AF131215.2	0.14	0.11	lasso	9	0.16	4.3e-13	5.1	-6.1	1.1e-09	0.85	0.84	0.16	FALSE
57	GTEx	Skin Sun Exposed Lower leg	AF131215.9	0.19	0.17	enet	29	0.21	3.9e-17	5.4	-6.3	2.8e-10	0.83	0.72	0.28	FALSE
58	GTEx	Small Intestine Terminal Ileum	AF131215.2	0.14	0.07	lasso	3	0.07	1.1e-02	4.7	-5.5	3.5e-08	0.83	0.08	0.67	FALSE
59	GTEx	Small Intestine Terminal Ileum	AF131215.9	0.14	0.11	enet	16	0.06	1.6e-02	4.6	-5.7	1.1e-08	0.75	0.14	0.32	FALSE
60	GTEx	Spleen	AF131215.2	0.16	0.08	enet	14	0.06	1.1e-02	5.4	-6.2	4.5e-10	0.86	0.10	0.76	FALSE
61	GTEx	Spleen	AF131215.9	0.34	0.23	enet	16	0.15	1.2e-04	-6.1	-6.3	3.4e-10	0.86	0.08	0.89	FALSE
62	GTEx	Testis	FAM86B3P	0.15	0.14	lasso	7	0.13	2.2e-06	-4.8	5.3	1.1e-07	-0.67	0.06	0.94	FALSE
63	GTEx	Testis	SGK223	0.29	0.02	enet	19	0.07	3.5e-04	-5.5	6.2	6.1e-10	-0.56	0.08	0.68	FALSE
64	GTEx	Testis	AF131215.9	0.12	0.21	lasso	4	0.14	5.6e-07	5.1	-5.2	1.9e-07	0.74	0.65	0.34	FALSE
65	GTEx	Thyroid	SGK223	0.19	0.35	enet	16	0.36	1.1e-28	-5.7	6.2	4.8e-10	-0.70	0.51	0.48	FALSE
66	GTEx	Thyroid	AF131215.2	0.11	0.15	enet	17	0.18	1.2e-13	5.1	-5.9	4.2e-09	0.83	0.84	0.16	FALSE
67	GTEx	Thyroid	AF131215.9	0.11	0.08	enet	16	0.17	4.7e-13	5.4	-6.3	2.8e-10	0.87	0.08	0.92	FALSE
68	GTEx	Uterus	AF131215.2	0.17	0.07	enet	13	0.09	7.1e-03	-6.6	-6.5	8.6e-11	0.90	0.06	0.80	FALSE
69	GTEx	Uterus	AF131215.9	0.16	-0.01	enet	18	0.03	7.5e-02	-5.9	-6.7	1.6e-11	0.80	0.06	0.73	FALSE
70	GTEx	Vagina	AF131215.2	0.20	0.14	lasso	3	0.11	1.9e-03	5.4	-5.6	2.2e-08	0.71	0.13	0.32	FALSE
71	GTEx	Vagina	AF131215.9	0.21	0.11	lasso	9	0.08	6.3e-03	-5.9	-6.2	5.0e-10	0.90	0.11	0.79	FALSE
72	NTR	Blood	MFHAS1	0.02	0.01	blup	759	0.01	2.9e-04	-6.1	-5.9	4.8e-09	0.64	0.16	0.84	FALSE
73	NTR	Blood	MSRA	0.02	0.01	blup	833	0.01	2.3e-05	-5.0	5.9	3.2e-09	-0.69	0.75	0.24	FALSE
74	ROSMAP	Brain Pre-frontal Cortex	MTMR9	0.07	0.06	enet	16	0.08	9.5e-11	4.6	5.5	4.5e-08	-0.72	0.99	0.01	FALSE
75	ROSMAP	Brain Pre-frontal Cortex	FAM167A	0.12	0.03	bslmm	620	0.08	1.3e-10	-3.0	5.4	6.1e-08	-0.69	0.05	0.95	FALSE
76	ROSMAP	Brain Pre-frontal Cortex	XKR6	0.11	0.10	enet	23	0.13	1.2e-16	5.2	-7.2	5.4e-13	0.82	0.16	0.84	TRUE
77	ROSMAP	Brain Pre-frontal Cortex	SLC35G5	0.19	0.21	enet	37	0.19	1.0e-23	4.6	5.1	2.9e-07	-0.73	1.00	0.00	FALSE
78	ROSMAP	Brain Pre-frontal Cortex	RP11-62H7.2	0.36	0.35	enet	35	0.39	1.7e-53	-4.8	-5.6	1.8e-08	0.63	0.94	0.06	FALSE
79	ROSMAP	Brain Pre-frontal Cortex	FAM85B	0.16	0.23	enet	18	0.22	1.8e-28	-5.1	5.7	1.1e-08	-0.69	0.96	0.04	FALSE
80	ROSMAP	Brain Pre-frontal Cortex	AF131215.3	0.08	0.10	lasso	7	0.12	8.3e-16	-6.9	-6.8	1.4e-11	0.89	0.06	0.94	FALSE
81	ROSMAP	Brain Pre-frontal Cortex	AF131215.2	0.49	0.57	lasso	7	0.57	9.0e-89	5.4	-5.5	3.2e-08	0.80	1.00	0.00	FALSE
82	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	FLJ10661	0.10	0.16	lasso	1	0.15	6.1e-13	-5.2	-5.2	2.1e-07	0.67	0.21	0.78	FALSE
83	The Cancer Genome Atlas	Breast Invasive Carcinoma	AMAC1L2	0.03	0.01	enet	6	0.02	1.7e-05	4.5	5.9	3.6e-09	-0.75	0.22	0.76	FALSE
84	The Cancer Genome Atlas	Colon Adenocarcinoma	FLJ10661	0.15	0.26	lasso	4	0.23	3.0e-13	-5.2	-5.4	8.3e-08	0.68	0.23	0.77	FALSE
85	The Cancer Genome Atlas	Esophageal Carcinoma	FLJ10661	0.20	0.23	lasso	2	0.23	5.6e-08	-5.1	-5.2	1.8e-07	0.65	0.22	0.77	FALSE
86	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	AMAC1L2	0.03	0.02	blup	55	0.03	1.8e-04	-4.7	6.5	8.3e-11	-0.69	0.03	0.92	FALSE
87	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	FLJ10661	0.07	0.14	lasso	3	0.14	3.7e-15	-5.2	-5.2	1.6e-07	0.67	0.22	0.78	FALSE
88	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TDH	0.05	0.01	blup	67	0.04	1.3e-05	-6.3	6.4	1.3e-10	-0.70	0.02	0.98	FALSE
89	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	AMAC1L2	0.04	0.00	blup	55	0.02	2.6e-02	4.4	6.1	1.0e-09	-0.74	0.02	0.68	FALSE
90	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	FLJ10661	0.07	0.02	blup	42	0.04	2.9e-03	-4.9	-5.2	2.5e-07	0.66	0.06	0.41	FALSE
91	The Cancer Genome Atlas	Brain Lower Grade Glioma	FLJ10661	0.21	0.26	lasso	9	0.30	2.3e-34	-5.1	5.9	4.1e-09	-0.66	0.26	0.74	FALSE
92	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	FLJ10661	0.09	0.07	blup	41	0.07	3.6e-04	5.4	-5.9	3.4e-09	0.62	0.01	0.86	FALSE
93	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	AMAC1L2	0.03	0.03	blup	55	0.04	3.0e-05	-6.2	6.2	6.9e-10	-0.78	0.01	0.98	FALSE
94	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	FLJ10661	0.17	0.11	enet	10	0.16	3.3e-07	5.8	-5.5	4.2e-08	0.59	0.01	0.98	FALSE
95	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	FLJ10661	0.25	0.18	lasso	4	0.16	4.2e-07	-5.1	5.2	1.7e-07	-0.66	0.18	0.82	FALSE
96	The Cancer Genome Atlas	Prostate Adenocarcinoma	AMAC1L2	0.04	0.04	blup	55	0.05	1.2e-05	-6.3	5.2	2.3e-07	-0.74	0.01	0.97	FALSE
97	The Cancer Genome Atlas	Prostate Adenocarcinoma	TDH	0.06	0.02	blup	67	0.06	1.5e-06	5.7	6.6	3.9e-11	-0.69	0.02	0.98	FALSE
98	The Cancer Genome Atlas	Stomach Adenocarcinoma	FLJ10661	0.08	0.05	blup	42	0.07	9.3e-06	-4.9	-5.2	2.5e-07	0.64	0.26	0.72	FALSE
99	The Cancer Genome Atlas	Testicular Germ Cell Tumors	FLJ10661	0.24	0.36	enet	8	0.35	4.1e-13	-5.2	-5.4	5.9e-08	0.64	0.10	0.90	FALSE
100	The Cancer Genome Atlas	Thyroid Carcinoma	SGK223	0.16	0.20	enet	14	0.22	6.1e-21	6.0	6.4	1.3e-10	-0.64	0.02	0.98	FALSE
101	The Cancer Genome Atlas	Thyroid Carcinoma	TDH	0.08	0.08	blup	67	0.09	8.1e-09	-6.1	5.9	4.7e-09	-0.68	0.01	0.99	FALSE