Best TWAS P=2.23e-16 · Best GWAS P=9.65e-18 conditioned to 0.00917
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | NEK10 | 0.04 | 0.03 | blup | 450 | 0.03 | 9.5e-05 | 5.0 | -7.0 | 3.3e-12 | 0.57 | 0.61 | 0.15 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | SLC4A7 | 0.09 | 0.00 | enet | 27 | 0.04 | 2.9e-05 | 6.8 | -6.0 | 1.8e-09 | 0.40 | 0.09 | 0.58 | FALSE |
| 3 | GTEx | Artery Aorta | SLC4A7 | 0.10 | 0.08 | enet | 15 | 0.08 | 5.4e-05 | -8.6 | -8.2 | 2.2e-16 | 0.92 | 0.00 | 0.99 | TRUE |
| 4 | GTEx | Cells Transformed fibroblasts | SLC4A7 | 0.15 | 0.02 | enet | 21 | 0.04 | 4.0e-04 | -8.6 | -7.1 | 1.4e-12 | 0.80 | 0.00 | 0.99 | FALSE |
| 5 | The Cancer Genome Atlas | Breast Invasive Carcinoma | NEK10 | 0.02 | 0.02 | lasso | 4 | 0.02 | 1.3e-05 | -5.6 | 5.7 | 1.0e-08 | -0.69 | 0.41 | 0.56 | FALSE |
| 6 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | SLC4A7 | 0.08 | 0.02 | lasso | 4 | 0.04 | 1.4e-03 | 2.9 | -5.3 | 1.1e-07 | 0.28 | 0.02 | 0.30 | FALSE |