Best TWAS P=8.17e-10 · Best GWAS P=8.92e-09 conditioned to 6.46e-06
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Visceral Omentum | AC006111.1 | 0.18 | 0.12 | enet | 12 | 0.10 | 1.1e-05 | 3.4 | 5.3 | 1.2e-07 | 0.02 | 0.64 | 0.03 | FALSE |
2 | GTEx | Brain Cortex | AC006111.1 | 0.32 | 0.02 | enet | 16 | 0.00 | 3.2e-01 | -4.1 | 5.4 | 6.3e-08 | -0.04 | 0.04 | 0.11 | TRUE |
3 | GTEx | Heart Atrial Appendage | MGRN1 | 0.33 | 0.30 | enet | 13 | 0.32 | 7.1e-15 | -3.7 | 5.3 | 1.1e-07 | -0.19 | 0.88 | 0.07 | FALSE |
4 | GTEx | Heart Left Ventricle | MGRN1 | 0.32 | 0.10 | enet | 18 | 0.33 | 3.6e-18 | 3.6 | 6.1 | 8.2e-10 | -0.20 | 0.87 | 0.06 | TRUE |
5 | GTEx | Muscle Skeletal | MGRN1 | 0.16 | 0.06 | lasso | 7 | 0.15 | 1.1e-14 | 3.7 | 5.9 | 4.5e-09 | -0.18 | 0.89 | 0.05 | FALSE |
6 | GTEx | Skin Not Sun Exposed Suprapubic | AC006111.1 | 0.19 | 0.12 | enet | 13 | 0.18 | 2.1e-10 | -2.8 | 5.7 | 1.3e-08 | 0.02 | 0.12 | 0.87 | TRUE |
7 | METSIM | Adipose | NUDT16L1 | 0.06 | 0.03 | bslmm | 392 | 0.04 | 2.2e-06 | -3.4 | -5.7 | 1.3e-08 | 0.33 | 0.71 | 0.24 | FALSE |
8 | The Cancer Genome Atlas | Breast Invasive Carcinoma | NAT15 | 0.05 | 0.04 | blup | 56 | 0.03 | 1.7e-07 | 4.4 | -5.5 | 3.4e-08 | -0.02 | 0.22 | 0.77 | FALSE |
9 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | TRAP1 | 0.11 | 0.01 | blup | 43 | 0.05 | 9.4e-04 | -1.6 | 5.1 | 2.8e-07 | 0.02 | 0.00 | 0.01 | FALSE |
10 | The Cancer Genome Atlas | Lung Adenocarcinoma | NAT15 | 0.06 | 0.04 | blup | 56 | 0.04 | 4.1e-05 | 5.4 | -5.4 | 6.7e-08 | -0.01 | 0.02 | 0.96 | FALSE |
11 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | NAT15 | 0.04 | 0.01 | blup | 56 | 0.04 | 4.2e-05 | 5.0 | -5.4 | 7.3e-08 | -0.05 | 0.02 | 0.92 | FALSE |
12 | The Cancer Genome Atlas | Thyroid Carcinoma | NAT15 | 0.10 | 0.05 | lasso | 6 | 0.07 | 6.1e-07 | 5.6 | -5.5 | 4.5e-08 | -0.04 | 0.01 | 0.99 | FALSE |