Best TWAS P=3.32e-13 · Best GWAS P=3.87e-13 conditioned to 0.221
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | CELSR2 | 0.03 | 0.00 | lasso | 10 | 0.01 | 1.5e-02 | -5.2 | 5.8 | 7.7e-09 | -0.58 | 0.10 | 0.34 | FALSE |
| 2 | GTEx | Esophagus Mucosa | PSRC1 | 0.18 | 0.14 | lasso | 3 | 0.14 | 2.4e-09 | -7.1 | -7.1 | 9.1e-13 | 0.97 | 0.00 | 1.00 | FALSE |
| 3 | GTEx | Liver | CELSR2 | 0.39 | 0.36 | lasso | 1 | 0.35 | 1.0e-10 | -7.1 | -7.1 | 1.0e-12 | 1.00 | 0.00 | 0.99 | FALSE |
| 4 | GTEx | Muscle Skeletal | CELSR2 | 0.41 | 0.31 | lasso | 4 | 0.30 | 2.4e-30 | -7.1 | -7.0 | 3.2e-12 | 1.00 | 0.01 | 0.99 | FALSE |
| 5 | GTEx | Skin Sun Exposed Lower leg | CELSR2 | 0.18 | 0.05 | lasso | 6 | 0.06 | 8.1e-06 | -6.1 | -5.9 | 4.5e-09 | 0.75 | 0.01 | 0.98 | FALSE |
| 6 | GTEx | Whole Blood | PSRC1 | 0.14 | 0.04 | lasso | 3 | 0.03 | 6.9e-04 | -7.2 | -7.3 | 4.0e-13 | 0.99 | 0.00 | 1.00 | FALSE |
| 7 | ROSMAP | Brain Pre-frontal Cortex | PSRC1 | 0.33 | 0.21 | bslmm | 430 | 0.26 | 1.2e-32 | -7.1 | -6.2 | 7.3e-10 | 0.82 | 0.00 | 1.00 | FALSE |
| 8 | ROSMAP | Brain Pre-frontal Cortex | CELSR2 | 0.25 | 0.21 | lasso | 6 | 0.23 | 4.9e-29 | -7.1 | -7.1 | 1.3e-12 | 0.96 | 0.00 | 1.00 | FALSE |
| 9 | YFS | Blood | PSRC1 | 0.25 | 0.18 | enet | 32 | 0.24 | 1.6e-76 | -7.1 | -6.2 | 6.9e-10 | 0.87 | 0.00 | 1.00 | FALSE |
| 10 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PSRC1 | 0.03 | 0.00 | blup | 49 | 0.02 | 5.7e-05 | -6.1 | -5.2 | 1.5e-07 | 0.80 | 0.01 | 0.93 | FALSE |
| 11 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | PSRC1 | 0.14 | 0.04 | enet | 13 | 0.07 | 2.7e-04 | -7.0 | -5.2 | 1.5e-07 | 0.73 | 0.01 | 0.79 | FALSE |
| 12 | The Cancer Genome Atlas | Colon Adenocarcinoma | PSRC1 | 0.07 | 0.06 | lasso | 1 | 0.04 | 1.8e-03 | -6.1 | -6.1 | 9.7e-10 | 0.75 | 0.01 | 0.84 | FALSE |
| 13 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | PSRC1 | 0.12 | 0.11 | lasso | 4 | 0.09 | 4.5e-06 | -6.8 | -6.7 | 2.0e-11 | 0.92 | 0.01 | 0.99 | FALSE |
| 14 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | PSRC1 | 0.16 | 0.20 | lasso | 3 | 0.19 | 3.7e-09 | -7.0 | -7.0 | 2.0e-12 | 0.95 | 0.01 | 0.99 | FALSE |
| 15 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | SORT1 | 0.23 | 0.16 | lasso | 4 | 0.16 | 4.6e-08 | -7.2 | -7.3 | 3.3e-13 | 0.94 | 0.00 | 1.00 | TRUE |
| 16 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | PSRC1 | 0.07 | 0.03 | enet | 8 | 0.05 | 3.4e-04 | -7.0 | -5.2 | 2.3e-07 | 0.77 | 0.01 | 0.93 | FALSE |
| 17 | The Cancer Genome Atlas | Stomach Adenocarcinoma | PSRC1 | 0.12 | 0.03 | enet | 6 | 0.08 | 1.5e-06 | -7.1 | -5.2 | 1.8e-07 | 0.77 | 0.00 | 0.98 | FALSE |