Hub : Genes

CELSR2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.035 0.0170 1.0e-02 0.002 0.003 0.003 0.003 0.011 1.6e-01 1.2e-01 1.2e-01 1.4e-01 1.5e-02
2 GTEx Liver 0.394 0.0950 7.8e-04 0.358 NA 0.305 NA 0.353 7.3e-11 NA 3.3e-09 NA 1.1e-10
3 GTEx Muscle Skeletal 0.410 0.0535 5.0e-16 0.310 NA 0.283 NA 0.305 6.2e-31 NA 7.3e-28 NA 2.4e-30
4 GTEx Skin Sun Exposed Lower leg 0.185 0.0710 2.1e-03 0.047 NA 0.055 NA 0.061 8.7e-05 NA 2.3e-05 NA 8.1e-06
5 METSIM Adipose 0.128 0.0351 1.1e-07 0.037 0.048 0.058 0.050 0.056 3.0e-06 1.1e-07 5.0e-09 5.8e-08 8.3e-09
6 ROSMAP Brain Pre-frontal Cortex 0.253 0.0396 5.6e-17 0.214 0.167 0.221 0.209 0.229 5.4e-27 7.1e-21 6.5e-28 2.7e-26 4.9e-29
7 TCGA Colon Adenocarcinoma 0.120 0.0570 2.7e-03 0.005 0.036 0.038 NA 0.010 1.6e-01 3.6e-03 3.0e-03 NA 8.6e-02
8 TCGA Stomach Adenocarcinoma 0.082 0.0420 8.6e-03 0.003 0.023 0.006 NA -0.002 1.9e-01 8.1e-03 1.1e-01 NA 4.9e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bipolar Disorder (2018) 1.0 1.5 3.7 -1.8 1.0 1.0 1.5 0.6 0.7 0.2 1.9
Bipolar Disorder or Schizophrenia 0.7 1.7 3.1 -0.4 1.4 1.6 1.6 1.7 1.5 -0.0 1.2
Depressed Affect (Nagel 2018) 0.8 1.7 3.0 -1.1 1.4 1.4 1.7 -0.9 1.2 1.6 0.5
Depression (Nagel 2018) 0.2 0.3 0.8 -0.9 0.4 0.3 0.4 -0.2 0.2 0.7 0.9
Intelligence (Savage-Jansen 2018) 1.0 3.0 10.8 -1.4 -0.2 -0.2 -0.4 -1.8 -0.3 -2.8 3.3
Neuroticism (Nagel 2018) 0.4 0.8 1.7 -1.1 0.8 0.7 1.3 -1.0 0.6 0.3 1.1
Schizophrenia (2018) 0.6 1.1 3.1 0.9 1.1 1.2 0.8 1.8 1.4 -0.2 -0.1
Schizophrenia vs Biploar Disorder 1.0 1.3 3.7 1.5 0.1 0.2 -0.8 1.4 0.5 -1.3 -1.9
Worry (Nagel 2018) 0.1 0.2 0.6 -0.4 0.0 0.0 0.2 -0.2 0.3 -0.8 0.5
Alzheimer’s Disease (in mother) 0.8 0.9 2.0 0.4 -1.1 -1.1 -1.3 0.5 -1.0 -1.4 -0.4
Alzheimer’s Disease (in father) 0.9 0.9 3.0 0.9 0.6 0.5 0.5 -1.7 0.5 1.5 -0.6
Alzheimer’s Disease (including proxy) 0.5 0.7 3.1 -0.1 -0.5 -0.6 -0.9 -1.8 -0.6 -0.1 -0.8
Crohns Disease (2017) 0.4 1.0 2.0 0.8 -0.9 -0.9 -1.4 1.1 -1.4 0.3 -0.5
Irritable Bowel Disease (IBD) 0.2 0.6 1.2 0.3 -0.7 -0.7 -0.7 1.1 -1.1 0.4 -0.4
Ulcerative Colitis (UC) 0.2 0.3 0.7 -0.3 -0.6 -0.6 -0.4 0.8 -0.8 -0.1 -0.1
Major Depression (MDD) 1.3 1.5 4.7 0.3 1.2 1.3 2.2 0.2 1.3 -0.2 1.6
Reaction Time 0.8 1.5 4.5 -1.2 0.8 0.7 0.9 -2.0 0.8 2.1 -0.2
Verbal and Numeric Reasoning (VNR) 0.4 1.1 4.5 -0.8 -0.2 -0.3 -0.9 -0.8 -0.3 -1.4 2.1
Breast Cancer 0.6 1.4 6.1 0.4 1.0 1.1 2.5 0.5 1.3 0.8 -0.2
Ovarian Cancer 0.1 0.2 0.5 -0.3 0.3 0.3 0.5 -0.3 0.3 0.7 -0.2
Prostate Cancer 0.2 0.2 1.1 1.1 -0.2 -0.2 -0.2 0.7 0.3 -0.4 -0.1
Age at First Birth 0.4 0.5 1.6 -0.8 0.5 0.5 1.3 -0.9 0.3 0.3 -0.5
Bipolar Disorder (2011) 0.3 0.3 1.2 -0.3 -0.5 -0.4 -0.5 1.1 -0.8 0.0 0.0
Body Mass Index (BMI) (2010) 1.8 2.4 3.7 -1.2 1.9 1.8 1.4 -1.3 1.8 1.9 0.4
Coronary Artery Disease (CAD) 18.3 21.9 31.1 4.4 -5.4 -5.3 -5.5 3.6 -5.6 -3.2 -3.8
Crohns Disease (2012) 1.3 2.0 3.6 1.1 -1.6 -1.6 -1.9 1.6 -1.6 -0.9 -0.9
Mean Putamen Volume 1.1 1.3 3.8 0.7 -0.8 -0.8 -1.9 -1.0 -1.1 -0.9 -1.3
Fasting Glucose 1.8 2.2 5.3 -1.1 1.4 1.5 2.3 -1.1 2.0 0.3 1.3
HbA1C 0.3 0.3 1.1 -0.5 0.0 -0.0 0.3 -0.4 -0.3 0.9 1.0
HDL Cholesterol 9.6 16.0 27.7 -4.6 5.3 5.1 3.4 -2.2 4.7 3.1 2.1
LDL Cholesterol 296.3 468.9 767.3 17.1 -27.7 -27.5 -23.4 9.3 -27.3 -17.2 -16.1
Lupus 0.5 0.8 3.5 1.1 -0.3 -0.4 -0.3 -1.9 -0.3 -1.0 0.2
Neuroticism (2016) 0.6 0.9 1.9 -0.2 -1.2 -1.3 -0.4 -0.7 -1.3 -1.4 0.0
Primary Biliary Cirrhosis 0.7 1.0 4.1 -0.5 0.6 0.6 0.9 1.4 0.3 2.0 0.2
Rheumatoid Arthritis 0.8 1.1 4.6 1.3 -0.9 -0.8 -0.2 0.4 -0.7 -2.1 0.4
Schizophrenia (2014) 0.3 0.6 1.3 0.3 0.6 0.7 0.1 1.1 0.9 -0.8 -0.8
Triglycerides 1.6 2.7 4.2 1.7 -1.8 -1.7 -2.1 0.5 -1.6 -1.8 -1.4
Type 2 Diabetes (T2D) (2012) 4.0 4.6 10.3 -3.2 2.1 2.0 1.1 -3.1 1.5 2.1 0.0
Ulcerative Colitis 0.2 0.3 0.9 -0.1 -0.6 -0.6 0.1 0.9 -0.5 0.3 -0.7
Blood Eosinophil Count 0.5 4.0 8.0 2.8 -1.8 -1.8 -2.8 -0.5 -2.2 -2.3 0.0
Blood Platelet Count 0.0 0.5 1.4 0.5 0.7 0.7 0.2 -0.5 0.5 1.2 -0.9
Blood Red Count 0.2 1.8 8.4 0.9 -0.0 -0.1 0.3 -2.3 0.1 -0.3 2.9
Blood White Count 0.6 4.2 8.3 0.6 2.9 2.8 1.7 -0.7 2.9 2.2 0.3
Heel T-Score 2.1 16.9 27.2 -3.5 5.0 4.9 3.1 -2.9 4.6 2.7 5.2
BMI 0.2 1.4 8.4 -0.5 0.5 0.5 -1.3 -0.1 0.4 -0.2 2.9
Height 1.6 29.9 55.2 -4.0 7.3 7.3 6.5 -1.8 7.4 3.9 1.1
Waist Hip Ratio (WHR) 0.9 4.0 10.1 -2.4 1.8 1.6 1.8 -3.2 1.4 1.4 1.9
Systolic Blood Pressure 0.2 1.2 3.0 -0.4 -1.3 -1.4 -0.9 0.2 -1.7 -0.6 1.3
Smoking Status 2.5 5.9 11.1 -2.5 3.3 3.3 1.5 -1.7 3.2 1.4 1.5
Allergy or Eczema 0.4 1.0 3.2 -1.1 0.6 0.5 -0.1 -1.8 0.3 1.4 0.9
Cardiovascular Disease 17.4 57.6 99.2 7.1 -10.0 -9.8 -7.1 3.4 -9.6 -7.4 -2.4
Hypothyroidism (self reported) 0.4 0.8 2.9 -0.2 -0.5 -0.5 -1.7 -0.5 -0.8 -0.8 -1.4
Respiratory disease 1.6 3.6 10.0 -1.0 2.0 2.1 1.7 -1.0 2.3 -0.7 3.2
Type 2 Diabetes (T2D) (2018) 0.3 0.6 2.0 0.4 0.8 0.8 -1.4 -0.5 0.8 0.6 -0.1
Lung FEV1/FVC ratio 3.5 17.8 32.9 3.2 -5.3 -5.3 -5.7 1.8 -5.2 -2.2 -2.9
Lung FVC 0.8 4.0 10.6 -0.4 1.9 2.1 3.3 2.6 1.6 1.3 1.4
Neuroticism 0.5 1.2 2.4 -1.3 0.7 0.7 1.2 -1.6 0.8 0.1 1.4
Chronotype (morning person) 1.0 2.3 8.4 0.4 -0.5 -0.3 -0.2 2.9 -0.1 -1.7 2.5
Hair Pigment 0.0 0.6 2.9 -0.5 -0.3 -0.3 -0.6 -0.2 -0.5 0.8 -1.7
Tanning 0.3 3.4 6.1 -1.9 2.3 2.2 1.2 -1.1 1.9 1.0 2.5
Hand grip strength (left) 1.3 3.4 7.9 -0.6 2.6 2.7 1.6 1.1 2.8 -0.3 0.8
Number of treatments/medications taken 8.4 15.2 23.2 3.1 -4.8 -4.7 -4.3 1.6 -4.8 -4.6 -1.4
Average weekly spirits intake 0.5 0.6 2.9 1.2 -0.0 -0.1 -0.2 -1.7 -0.1 0.4 -0.6
Sensitivity / hurt feelings 0.9 1.6 3.6 -1.0 1.2 1.3 1.5 -0.6 1.3 -0.7 1.9
Frequency of depressed mood in last 2 weeks 0.7 1.0 4.2 -2.0 0.6 0.5 0.2 0.0 0.3 1.7 0.4
Hearing difficulty/problems: Yes 4.1 6.2 11.5 -1.3 3.4 3.4 2.6 -1.2 3.4 2.1 1.1
Relative age of first facial hair 0.3 0.6 2.4 0.5 -0.1 -0.2 0.4 -1.0 0.2 0.8 -1.5
Other serious medical condition/disability diagnosed by doctor 4.5 5.8 8.8 2.5 -3.0 -3.0 -2.8 0.5 -2.9 -1.9 -1.7
Ever used hormone-replacement therapy (HRT) 1.7 2.2 5.3 -0.6 1.7 1.6 1.2 -1.4 1.4 2.3 -1.0
Ever had hysterectomy (womb removed) 0.4 0.5 2.0 -0.2 0.4 0.4 1.4 0.4 0.7 -0.2 -1.0
Systolic blood pressure, automated reading 0.3 0.9 2.6 -1.6 0.2 0.1 0.5 -1.6 -0.1 -0.1 1.3
Eye problems/disorders: Diabetes related eye disease 0.3 0.3 0.8 0.7 -0.2 -0.3 -0.9 -0.8 -0.4 0.1 0.7
Angina 23.8 31.2 47.1 5.7 -6.9 -6.7 -5.7 3.2 -6.7 -4.7 -3.9
Medication for hormone replacement therapy 0.5 0.5 2.0 1.0 0.5 0.6 0.3 -0.2 0.6 1.4 0.4
Vitamin and mineral supplements 0.3 0.4 1.0 0.7 -0.6 -0.6 -0.9 0.3 -0.6 0.0 -1.0
Supplements: Zinc 0.6 0.7 1.3 -0.6 1.0 1.1 0.6 -0.1 1.2 -0.0 0.9
Medication: Co-codamol 1.0 1.1 1.7 1.3 -1.1 -1.1 -1.1 0.5 -0.9 -1.0 -1.2
Medication: Metformin 0.5 0.7 1.6 0.3 1.2 1.3 -1.1 0.2 0.8 1.1 0.1
Diabetes (father) 3.5 4.3 7.3 -1.2 2.3 2.2 1.7 -2.1 2.7 2.7 -0.8
Diabetes (mother) 2.1 2.7 6.1 -1.1 2.3 2.3 1.4 -1.1 2.5 0.5 0.4
Severe depression (siblings) 0.5 0.5 1.5 0.5 -0.2 -0.2 -1.2 1.1 -0.1 -0.8 -0.8
Pack years adult smoking proportion 0.6 0.9 2.6 1.4 0.3 0.3 -0.1 -0.7 0.3 1.3 -1.6
Impedance of leg (right) 1.6 7.7 30.5 1.8 -2.9 -3.0 -1.1 0.8 -2.8 0.6 -5.5
Leg fat-free mass (left) 1.2 6.3 12.2 -1.4 3.4 3.5 1.9 0.0 3.4 0.4 3.1
Trunk fat percentage 0.5 1.9 5.1 1.0 -1.2 -1.3 -2.0 -0.4 -1.3 0.6 -2.3
Hand grip strength (right) 1.7 4.6 9.3 -0.7 3.0 3.0 1.9 1.7 3.0 1.2 1.3
Townsend deprivation index at recruitment 0.7 0.9 2.7 0.9 -0.4 -0.3 1.2 1.6 0.1 -0.4 1.5
Current tobacco smoking 2.2 3.7 5.6 -2.2 2.4 2.3 0.8 -2.2 2.4 1.6 -0.4
Average weekly fortified wine intake 0.9 1.1 4.8 -0.8 0.7 0.6 0.9 -2.2 0.6 -0.4 1.1
Maternal smoking around birth 0.8 1.2 2.7 -0.1 -1.2 -1.2 -0.9 1.6 -1.5 0.2 -0.8
Fed-up feelings 2.8 5.0 7.8 -2.1 2.4 2.3 2.7 -0.9 2.2 2.8 2.0
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.6 1.3 -0.6 -0.8 -0.9 -1.0 0.3 -1.1 -0.3 0.6
Relative age voice broke 0.2 0.3 0.9 -0.8 -0.1 -0.2 -0.1 -0.9 -0.3 0.9 0.3
Taking other prescription medications 1.0 1.5 4.6 0.5 -1.1 -1.0 -1.9 0.4 -1.0 -2.1 -0.3
Age when periods started (menarche) 0.5 1.1 2.8 0.3 -0.9 -1.0 0.6 -1.4 -0.2 -1.3 -1.7
Bilateral oophorectomy (both ovaries removed) 0.3 0.4 1.1 0.2 -0.1 -0.1 0.8 -0.6 0.0 0.9 -1.1
Heel bone mineral density (BMD) T-score, automated (left) 0.8 1.8 5.7 -0.9 1.8 1.7 0.5 -0.4 1.2 0.7 2.4
Tinnitus: Yes, but not now, but have in the past 0.8 0.9 4.1 -1.2 0.5 0.4 0.7 0.8 0.3 2.0 0.3
Qualifications: CSEs or equivalent 2.1 2.7 4.5 1.9 -1.9 -1.9 -0.5 2.1 -2.0 -1.5 0.3
Serious illness, injury or assault to yourself 2.4 2.9 5.3 1.4 -2.2 -2.1 -1.0 1.2 -2.3 -1.7 -1.2
High blood pressure 0.7 1.9 8.5 -0.9 0.4 0.2 1.3 -2.9 -0.0 0.9 1.6
Hayfever, allergic rhinitis or eczema 0.1 0.2 0.8 0.1 0.1 0.1 -0.5 -0.9 -0.0 0.6 -0.2
Multivitamins +/- minerals 0.3 0.4 1.5 -0.7 0.5 0.5 0.4 0.5 0.6 -0.3 1.2
Stomach or abdominal pain in last month 0.6 0.7 2.6 0.8 -0.0 0.1 -0.2 1.5 0.6 0.4 -1.6
Supplements: Glucosamine 2.8 3.6 7.9 -1.4 2.4 2.4 1.1 -1.9 2.8 0.0 1.7
Diverticular disease/diverticulitis (self-reported) 0.6 0.7 3.0 0.0 0.5 0.7 -0.4 0.8 0.8 -1.7 0.8
Medication: Atenolol 5.8 7.2 12.7 1.8 -3.2 -3.2 -3.6 0.4 -3.6 -2.2 -1.8
Medication: Levothyroxine sodium 0.3 0.6 1.5 -0.5 -0.6 -0.7 -0.5 -1.1 -0.7 0.3 -1.2
Sitting height 0.1 1.0 2.0 0.1 1.3 1.3 0.8 -0.3 1.4 0.9 -0.9
Chronic bronchitis/emphysema (father) 0.4 0.4 1.6 -0.3 -0.2 -0.2 -0.7 0.8 -0.1 -1.3 0.8
High blood pressure (mother) 1.3 1.8 3.7 1.6 -1.5 -1.4 -1.2 1.9 -1.3 -0.8 0.6
Body mass index (BMI) 0.1 0.6 3.1 -0.4 0.2 0.2 -0.9 -0.5 -0.1 -0.2 1.8
Impedance of leg (left) 1.6 7.8 32.5 1.3 -2.9 -3.0 -1.2 0.2 -2.8 1.2 -5.7
Leg predicted mass (left) 1.3 6.6 12.9 -1.5 3.5 3.6 2.0 0.0 3.5 0.4 3.1
Trunk fat mass 0.1 0.3 0.8 0.2 0.1 0.1 -0.8 -0.7 0.1 0.7 -0.9
Waist circumference 0.4 1.4 3.8 -0.8 1.2 1.1 0.3 -1.9 1.1 0.7 1.5
Number of incorrect matches in round 0.4 0.7 4.7 -0.5 0.3 0.3 2.2 0.2 0.1 0.7 -0.0
Past tobacco smoking 0.4 0.7 3.6 1.1 -0.2 -0.2 -0.6 -0.3 -0.1 0.1 -1.9
Alcohol usually taken with meals 0.2 0.3 0.7 -0.2 -0.8 -0.8 -0.1 -0.1 -0.7 -0.5 0.4
Nervous feelings 0.2 0.3 1.3 -0.8 0.1 0.0 0.1 -0.2 0.1 -1.2 0.4
Frequency of tenseness / restlessness in last 2 weeks 0.9 1.4 3.1 -0.9 -1.4 -1.5 -1.1 0.3 -1.8 0.6 -1.1
Hearing difficulty/problems with background noise 1.1 1.8 3.8 -0.9 1.7 1.7 1.7 -1.0 1.9 0.2 0.7
Hair/balding pattern: Pattern 2 0.3 0.4 1.1 0.9 0.2 0.2 1.1 0.3 0.5 -0.8 0.4
Had menopause 2.6 3.2 6.2 -0.5 2.0 1.9 2.5 -2.0 2.2 1.3 -0.8
Had other major operations 0.1 0.1 0.5 0.7 -0.1 -0.2 -0.1 0.4 0.2 -0.1 -0.5
Forced vital capacity (FVC) 0.5 1.8 10.8 0.1 0.8 1.0 0.5 3.3 0.5 0.6 -1.0
Heel bone mineral density (BMD) T-score, automated (right) 1.4 3.1 6.9 -1.7 2.1 2.0 0.9 -0.5 1.6 1.7 2.6
Ever unenthusiastic/disinterested for a whole week 2.0 2.5 6.8 0.9 -1.6 -1.5 -1.8 2.6 -1.4 -1.1 -1.1
Qualifications: None of the above 0.9 1.9 9.6 -0.1 0.5 0.4 0.9 -0.5 0.2 3.1 -2.1
Financial difficulties in last 2 years 0.8 1.1 2.0 1.0 -1.4 -1.4 -0.2 0.6 -1.2 -1.3 0.3
Mouth/teeth dental problems 0.5 0.7 1.1 -0.9 1.0 1.0 0.7 1.0 1.1 0.4 0.5
Heart attack 18.1 23.2 31.3 5.1 -5.6 -5.5 -5.1 1.5 -5.5 -4.9 -4.0
Allergy 0.1 0.3 0.5 0.7 -0.6 -0.7 0.2 -0.5 -0.4 -0.5 -0.6
Pain all over the body in last month 0.5 0.6 1.2 -0.2 -1.1 -1.1 -0.6 0.9 -0.9 -0.0 0.6
Diabetes (self-reported) 0.3 0.4 1.9 0.4 0.2 0.2 -1.4 -0.9 -0.0 -0.4 -0.2
Hayfever/allergic rhinitis (self-reported) 0.4 0.5 1.5 -0.5 0.8 0.9 0.4 -0.5 1.2 0.0 0.4
Medication: Ramipril 3.5 4.5 6.8 2.2 -2.4 -2.4 -2.5 0.2 -2.5 -2.6 -0.9
Medication: Simvastatin 60.7 89.1 153.8 7.4 -12.4 -12.3 -9.6 2.3 -12.2 -8.5 -5.9
Fluid intelligence score 0.3 0.7 3.4 -0.6 -0.2 -0.2 -0.5 -0.4 -0.1 -1.8 1.2
Illnesses of siblings 1.8 2.6 3.9 -1.0 2.0 2.0 1.8 -0.2 1.9 1.2 1.9
Neuroticism score 0.9 1.8 5.3 -2.3 1.2 1.2 1.2 -1.1 1.1 0.9 1.4
Weight 0.5 2.4 4.6 -1.1 2.1 2.2 0.9 -1.0 2.1 1.0 1.3
Impedance of arm (right) 2.4 11.3 49.3 2.3 -3.1 -3.2 -2.6 0.6 -2.9 0.2 -7.0
Arm fat percentage (right) 0.4 1.6 5.2 0.7 -1.3 -1.3 -2.3 -0.4 -1.4 0.0 -1.4
Trunk fat-free mass 2.7 15.4 26.2 -3.0 5.1 5.1 4.1 -1.2 5.1 1.5 4.0
Hip circumference 0.0 0.2 0.7 0.8 0.1 0.2 -0.5 -0.1 0.3 0.3 -0.4
Time employed in main current job 0.7 0.9 3.6 -1.0 -0.7 -0.7 -0.4 1.9 -0.9 0.5 -0.1
Alcohol intake versus 10 years previously 2.2 3.2 5.4 -0.4 2.1 2.2 2.2 -0.3 2.0 1.3 2.3
Father’s age at death 9.3 12.5 20.7 -3.1 4.5 4.5 2.8 -2.1 4.3 1.6 3.9
Worrier / anxious feelings 1.1 2.0 4.0 -1.3 1.9 2.0 1.4 -0.8 2.0 0.6 0.0
Frequency of tiredness / lethargy in last 2 weeks 0.6 0.9 2.7 -0.5 -1.1 -1.2 -1.0 -0.2 -1.6 -0.4 0.8
Falls in the last year 0.2 0.2 0.7 0.9 0.6 0.6 0.4 0.1 0.4 0.3 0.3
Hair/balding pattern: Pattern 3 0.5 0.7 0.9 0.9 0.9 0.9 0.5 -0.7 0.8 -0.9 0.9
Number of live births 0.8 1.2 5.4 0.2 0.2 0.1 -1.1 -1.3 0.0 1.1 -2.3
Forced expiratory volume in 1-second (FEV1) 0.7 2.2 13.8 0.8 -0.5 -0.4 -0.7 3.7 -0.8 0.3 -1.3
Pulse rate 1.3 2.2 6.0 0.9 -1.6 -1.5 -1.7 2.4 -1.5 -0.2 -0.8
Happiness 0.7 0.9 3.8 -1.9 0.3 0.2 0.5 0.9 0.1 0.9 1.1
Noisy workplace 2.4 2.9 11.3 -1.4 1.6 1.5 1.1 -1.3 1.3 3.4 -0.9
Qualifications: A levels/AS levels or equivalent 0.8 1.8 9.1 0.2 -0.4 -0.4 -1.4 0.6 -0.3 -3.0 1.6
Serious illness, injury or assault of a close relative in last 2 years 0.9 1.0 2.7 1.6 -0.9 -0.9 -0.4 0.8 -0.9 -0.9 1.2
Mouth/teeth dental problems: Dentures 0.3 0.6 2.3 -0.1 0.3 0.2 -0.1 -1.5 -0.1 -1.0 1.1
Asthma 0.7 1.4 5.6 0.1 0.6 0.7 0.8 1.5 0.8 -1.0 2.4
Medication: Ibuprofen (e.g. Nurofen) 0.9 1.2 2.7 0.6 0.8 0.9 1.5 1.7 1.1 0.5 1.0
Medication: Cholesterol lowering 92.0 143.0 243.4 9.9 -15.6 -15.5 -12.4 3.7 -15.3 -10.8 -6.7
Depression (self-reported) 0.8 1.0 5.8 -2.4 0.2 0.2 -0.3 0.5 0.1 0.7 -1.2
Medication: Lansoprazole 0.2 0.2 0.9 -0.6 0.4 0.4 0.4 -0.1 0.4 0.1 0.9
Prospective memory result 1.8 2.2 5.5 -1.0 2.0 2.0 1.6 -0.7 2.3 -0.1 0.5
Lung cancer (father) 2.3 2.7 5.6 -0.4 1.8 1.8 1.9 -0.5 2.0 2.4 -1.1
Illnesses of mother 1.3 1.6 4.0 -1.7 1.3 1.2 1.2 -0.1 1.0 2.0 -0.8
Forced expiratory volume in 1-second (FEV1), Best measure 0.6 1.8 12.1 0.1 0.6 0.7 -0.1 3.5 0.3 1.1 -0.2
Pulse wave Arterial Stiffness index 0.6 0.6 2.4 -0.8 -0.2 -0.4 -0.9 -1.5 -0.0 0.5 -0.9
Impedance of arm (left) 2.0 9.3 35.4 2.2 -3.1 -3.1 -2.4 0.5 -2.9 0.1 -6.0
Arm fat mass (right) 0.1 0.3 0.6 -0.4 0.5 0.5 -0.8 -0.6 0.3 0.7 0.3
Trunk predicted mass 2.7 15.4 26.2 -3.0 5.1 5.1 4.1 -1.2 5.1 1.5 4.0
Standing height 1.2 12.2 24.5 -2.0 4.7 4.7 4.0 -1.4 5.0 2.6 -0.7
Length of working week for main job 0.8 0.9 2.7 -0.4 -1.0 -1.0 -1.1 -0.0 -1.0 -0.4 1.6
Exposure to tobacco smoke at home 1.1 1.3 6.5 0.3 -1.0 -1.0 -1.0 -0.1 -0.6 0.6 -2.5
Breastfed as a baby 0.7 0.9 2.2 -0.4 1.3 1.3 0.0 -1.5 1.1 -0.1 0.3
Tense / ‘highly strung’ 0.9 1.4 2.6 0.3 -1.5 -1.5 -1.4 0.9 -1.2 -1.6 0.0
Seen doctor (GP) for nerves, anxiety, tension or depression 0.7 1.0 6.5 -0.4 -0.3 -0.2 -0.8 2.5 0.2 -0.7 0.6
Hair/balding pattern: Pattern 4 0.3 0.7 2.9 -1.7 -0.3 -0.3 -0.2 0.5 -0.7 1.3 0.1
Birth weight of first child 1.0 1.8 7.1 -1.3 1.4 1.4 0.4 0.3 1.1 0.6 2.7
Peak expiratory flow (PEF) 1.1 2.6 9.5 2.6 -0.7 -0.5 -1.1 3.1 -0.5 -0.6 -1.4
Pulse wave reflection index 1.0 1.2 4.8 -1.8 0.5 0.3 0.0 -2.2 0.3 1.1 0.1
Ever highly irritable/argumentative for 2 days 0.3 0.4 1.0 -1.0 0.2 0.2 0.9 -0.8 0.3 0.7 0.3
Loud music exposure frequency 0.9 1.0 4.6 0.9 0.4 0.4 2.1 0.2 0.6 -0.3 1.4
Qualifications: O levels/GCSEs or equivalent 1.6 2.5 12.6 2.1 -0.9 -0.8 -1.1 0.0 -0.3 -3.5 0.7
Mouth/teeth dental problems: Bleeding gums 0.6 0.8 1.9 0.3 -1.4 -1.4 -0.5 -0.1 -1.2 0.2 -0.8
Blood clot in the leg (DVT) 0.6 0.8 2.4 -0.9 0.8 0.8 1.5 0.4 1.0 0.9 0.4
Medication: Paracetamol 0.2 0.4 1.2 1.1 -0.4 -0.3 -0.2 1.0 -0.1 -0.9 -0.0
Headache pain in last month 0.7 1.3 3.1 1.8 -1.1 -1.0 -1.2 1.0 -0.7 -0.9 -1.1
Medication for cholesterol, blood pressure or diabetes 30.0 49.6 81.7 -6.4 9.0 8.9 7.3 -1.6 8.9 6.9 3.3
Glaucoma (self-reported) 0.6 0.7 1.9 -0.7 1.4 1.4 0.1 0.4 1.1 0.6 -0.1
Gout (self-reported) 1.9 2.6 4.6 -1.4 2.1 2.1 1.1 -1.7 2.0 1.4 0.1
Hypothyroidism/myxoedema (self-reported) 0.2 0.3 1.7 -0.5 0.3 0.3 -0.2 -0.7 0.1 0.4 -1.3
Medication: Amlodipine 0.9 1.3 4.8 2.2 -1.3 -1.1 -0.5 0.2 -1.2 -0.9 -0.0
Medication: Ventolin 100micrograms inhaler 3.2 4.2 7.6 -0.4 2.5 2.5 2.7 0.5 2.3 0.4 2.8
Birth weight 1.2 2.6 9.2 1.0 -1.5 -1.4 -2.2 0.5 -1.1 -3.0 0.3
Chronic bronchitis/emphysema (mother) 1.2 1.4 3.1 0.5 -1.3 -1.3 -1.8 -0.7 -1.4 -0.1 -1.4
High blood pressure (siblings) 2.4 3.5 6.3 1.2 -2.3 -2.3 -2.5 0.4 -2.3 -1.7 -1.1
Forced vital capacity (FVC), Best measure 0.7 2.6 8.8 -0.7 1.7 1.8 1.2 3.0 1.3 1.5 0.3
Body fat percentage 0.5 2.0 4.3 0.9 -1.4 -1.4 -2.1 -0.4 -1.5 0.4 -2.1
Leg fat percentage (right) 0.4 1.4 2.8 1.0 -1.3 -1.4 -1.2 -0.7 -1.4 0.3 -1.7
Arm fat-free mass (right) 2.6 13.3 21.3 -2.7 4.6 4.6 3.8 -0.8 4.6 1.8 4.3
Exposure to tobacco smoke outside home 1.6 2.1 12.0 -0.6 0.3 0.2 1.3 -1.6 -0.2 3.5 -0.2
Comparative body size at age 10 0.2 0.5 2.1 -0.3 0.0 0.1 -1.5 0.1 0.1 -0.8 1.1
Number of full brothers 0.4 0.5 1.3 0.2 0.6 0.6 0.0 1.1 1.2 0.5 -0.8
Worry too long after embarrassment 0.9 1.5 3.2 -1.8 0.9 0.8 0.9 -1.8 0.7 1.7 -0.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.3 1.1 -0.5 0.2 0.3 -0.6 1.0 0.6 -0.0 -0.3
Wheeze or whistling in the chest in last year 1.4 2.6 4.6 0.4 1.8 1.9 1.9 0.4 2.0 -1.1 2.1
Number of children fathered 0.6 0.7 1.9 0.9 -0.6 -0.6 -1.0 0.3 -0.3 -1.4 -1.0
Reason for reducing amount of alcohol drunk: Health precaution 1.3 1.6 6.2 0.7 -0.9 -0.9 -0.0 -0.7 -1.0 -2.5 1.6
Age at first live birth 0.3 0.5 1.5 -0.7 0.6 0.5 0.4 0.5 0.1 1.1 1.2
Pulse wave peak to peak time 0.7 0.8 2.5 0.8 0.6 0.7 1.2 1.6 0.4 -0.4 0.7
Health satisfaction 1.1 1.4 3.2 0.4 -1.8 -1.8 -1.2 0.7 -1.6 -0.5 0.4
Shortness of breath walking on level ground 0.3 0.4 1.4 1.2 -0.7 -0.7 0.3 -0.1 -0.4 -0.2 -0.4
Qualifications: College or University degree 0.7 2.2 5.0 -2.0 1.1 1.1 -0.4 -0.6 1.4 -2.0 2.2
Eye problems/disorders: None of the above 0.2 0.2 0.6 -0.8 0.1 0.1 0.3 0.5 0.3 -0.4 0.4
Mouth/teeth dental problems: Loose teeth 0.5 0.6 1.5 1.1 -0.8 -0.8 -1.2 0.3 -0.8 -0.3 -0.4
Emphysema/chronic bronchitis 0.9 1.0 3.7 -0.5 0.8 0.8 1.0 1.0 0.5 0.6 1.9
Medication for pain relief, constipation, heartburn 4.9 8.4 15.5 -3.9 3.2 3.0 2.7 -2.3 2.6 3.0 1.8
Neck or shoulder pain in last month 3.0 4.2 9.0 1.5 -2.3 -2.3 -2.4 1.3 -1.9 -0.8 -3.0
Medication: Blood pressure 1.9 3.4 5.0 1.9 -2.1 -2.0 -2.2 -0.2 -2.2 -2.2 0.3
Angina (self-reported) 25.2 33.1 50.8 5.8 -7.1 -7.0 -5.9 3.3 -7.1 -4.6 -3.9
Migraine (self-reported) 1.5 1.8 3.8 1.6 -1.7 -1.7 -1.9 0.0 -1.3 -0.4 -0.8
Medication: Ibuprofen 0.9 1.1 2.4 0.6 0.8 0.9 1.5 1.2 1.1 0.0 1.4
Medication: Allopurinol 1.1 1.5 3.2 -0.8 1.7 1.8 0.9 -0.3 1.8 0.7 0.6
Medication: Omeprazole 0.7 0.9 2.0 0.2 -1.0 -1.0 -1.4 0.5 -1.1 -0.8 -0.8
Medication: Seretide 50 evohaler 1.6 1.8 3.6 -0.5 1.6 1.6 1.5 -1.9 1.5 0.5 0.9
Mean time to correctly identify matches 1.9 3.7 11.7 -1.4 1.5 1.4 1.7 -3.4 1.6 2.5 -0.1
Heart disease (mother) 1.7 2.0 3.9 1.1 -2.0 -1.9 -1.3 0.3 -1.9 -1.3 -0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.7 1.6 1.0 -0.6 -0.5 -0.0 1.3 -0.7 0.6 -1.1
Whole body fat mass 0.1 0.3 0.7 0.1 0.4 0.3 -0.8 -0.7 0.3 0.8 -0.7
Leg fat mass (right) 0.0 0.1 0.3 0.3 0.2 0.2 -0.5 -0.6 0.1 0.4 -0.0
Arm predicted mass (right) 2.6 13.4 21.3 -2.8 4.6 4.6 3.7 -0.5 4.5 1.9 4.4
Pulse rate, automated reading 2.0 6.5 13.5 2.4 -2.7 -2.6 -3.2 3.7 -2.4 -1.3 -1.3
Alcohol intake frequency. 0.2 0.4 0.6 0.7 -0.8 -0.8 0.7 -0.1 -0.7 -0.6 0.2
Comparative height size at age 10 1.6 9.0 15.7 -1.9 4.0 3.9 2.6 -0.8 3.9 3.7 -0.7
Number of full sisters 0.5 0.6 1.5 0.4 -0.6 -0.7 -0.7 -1.2 -0.5 0.5 -0.9
Suffer from ‘nerves’ 0.2 0.4 1.4 -0.4 -0.1 -0.0 -0.4 0.9 -0.0 1.2 -0.6
Overall health rating 1.0 2.3 3.2 1.5 -1.7 -1.8 -1.8 -1.1 -1.6 -0.6 -1.6
Chest pain or discomfort 3.6 5.2 8.6 2.0 -2.6 -2.5 -2.9 1.5 -2.4 -2.4 -1.5
Had major operations 3.2 3.8 9.1 1.3 -2.0 -2.0 -3.0 0.7 -2.0 -1.5 -2.1
Age at last live birth 0.3 0.4 0.9 0.4 -0.6 -0.6 -0.6 0.3 -0.9 -0.3 1.0
Family relationship satisfaction 0.3 0.4 0.7 0.4 -0.7 -0.8 0.9 -0.7 -0.4 -0.0 0.8
Leg pain on walking 0.6 0.8 1.8 0.1 0.6 0.6 1.1 -0.9 0.8 1.4 -1.1
Qualifications: NVQ or HND or HNC or equivalent 0.9 1.1 4.0 1.4 -0.4 -0.4 -0.8 2.0 -0.2 0.3 -1.2
Commuting to job workplace: Car/motor vehicle 0.6 0.7 1.7 1.3 -0.4 -0.4 -1.2 -0.7 -0.5 -0.3 -1.2
Illness, injury, bereavement, stress in last 2 years 0.9 1.0 2.2 -1.3 0.8 0.7 -0.3 -1.3 0.4 1.5 -1.2
Medication: Aspirin 17.8 23.4 36.4 5.0 -6.0 -5.9 -4.7 1.6 -5.7 -5.1 -2.9
Supplements: Vitamin C 2.9 3.5 7.8 -1.3 2.0 1.9 2.8 -2.4 1.7 1.2 0.9
Knee pain experienced in last month 0.3 0.5 2.1 -1.2 0.4 0.3 0.4 -1.5 0.3 -0.0 -0.2
Hypertension (Self-reported) 0.5 1.3 7.1 -0.3 -0.2 -0.3 0.9 -2.7 -0.6 0.6 1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.4 0.5 1.7 -1.2 0.0 -0.1 -0.3 0.4 -0.5 1.3 -0.1
Illnesses of father: Heart disease 19.8 27.4 47.2 2.9 -6.5 -6.5 -6.8 1.3 -6.9 -4.4 -3.6
Illnesses of siblings: Diabetes 1.1 1.4 4.9 -1.4 0.9 0.7 0.6 -2.2 0.9 0.7 -1.2
Smoking status: Previous 0.5 0.8 3.7 -0.5 -0.3 -0.3 0.3 1.0 -0.4 -0.8 1.9
Forced expiratory volume in 1-second (FEV1), predicted 1.6 3.4 7.9 0.0 2.4 2.5 1.8 0.8 2.8 0.4 1.9
Whole body fat-free mass 2.2 12.8 22.6 -2.6 4.7 4.8 3.4 -0.8 4.7 1.2 3.9
Leg fat-free mass (right) 1.5 7.9 14.7 -1.9 3.8 3.8 2.2 -0.3 3.7 0.8 3.4
Arm fat percentage (left) 0.3 1.0 3.6 0.5 -1.0 -1.0 -1.9 -0.4 -1.1 0.2 -0.9
Average weekly red wine intake 3.1 4.6 7.8 1.7 -2.2 -2.2 -2.5 0.1 -2.2 -2.8 -2.3
Handedness (chirality/laterality): Left-handed 0.7 0.8 3.0 0.5 0.6 0.7 -0.2 1.0 1.0 -1.7 0.5
Mood swings 0.9 1.7 4.8 -1.4 1.2 1.0 1.3 -1.3 0.6 2.2 0.4
Loneliness, isolation 0.1 0.2 0.5 -0.1 0.2 0.2 0.2 -0.5 0.5 -0.7 -0.7
Long-standing illness, disability or infirmity 0.8 1.3 2.9 1.1 -1.2 -1.1 -1.7 0.3 -0.7 -1.5 -0.9
Ever had bowel cancer screening 0.2 0.3 0.7 0.8 -0.3 -0.2 -0.5 -0.8 -0.3 0.6 0.2
Diabetes diagnosed by doctor 0.3 0.6 3.1 0.9 -0.2 -0.1 -1.8 -0.4 -0.1 -0.5 -0.3
Ever had stillbirth, spontaneous miscarriage or termination 1.0 1.1 3.1 -0.5 0.6 0.5 -1.0 -1.7 0.1 1.1 -1.7
Friendships satisfaction 0.3 0.4 0.8 0.7 -0.8 -0.9 -0.3 0.2 -0.9 -0.7 -0.1
Qualifications: nursing, teaching 1.2 1.9 11.6 0.8 -0.6 -0.4 -0.9 -0.4 -0.3 -3.4 1.1
Commuting to job workplace: Walk 2.4 2.6 4.6 0.9 -2.2 -2.1 -0.8 1.3 -2.0 -1.7 1.2
Eye problems/disorders: Cataract 0.7 0.8 3.1 0.0 0.1 0.1 1.4 -1.2 -0.0 1.8 0.2
Mouth/teeth dental problems: Mouth ulcers 0.6 1.0 3.2 1.1 -0.6 -0.6 -0.6 1.8 -0.5 1.1 -0.9
Medication for cholesterol 9.2 14.0 25.1 -3.6 4.9 4.9 3.9 -0.2 5.0 2.1 2.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.2 0.5 0.7 0.1 0.2 -0.7 0.3 -0.0 0.1 0.6
Back pain experienced in last month 0.7 1.0 4.5 -0.9 -0.3 -0.4 -0.9 -0.5 -0.5 1.0 -2.1
Mineral and other dietary supplements 0.5 0.7 3.0 0.6 -0.8 -0.6 -0.0 1.7 -1.0 0.6 0.2
Breast cancer (self-reported) 1.1 1.3 2.4 -0.2 -1.4 -1.4 -1.0 1.2 -1.1 -1.5 0.4
Asthma (self-reported) 0.6 1.2 4.4 -0.0 0.5 0.7 0.8 1.3 0.8 -1.1 2.1
Osteoporosis (self-reported) 0.3 0.4 0.8 0.7 -0.7 -0.8 -0.7 0.4 -0.9 -0.3 -0.3
Osteoarthritis (self-reported) 2.1 2.7 6.2 -1.5 2.3 2.4 1.5 -0.1 2.5 0.0 0.3
Medication: Aspirin 18.5 24.2 38.7 4.8 -6.2 -6.1 -4.9 1.5 -6.0 -4.8 -2.9
Medication: Gliclazide 1.7 1.9 6.2 1.3 -0.2 -0.0 -1.7 2.0 0.1 -2.5 -0.5
Illnesses of father: None of the above (group 1) 2.6 3.2 8.1 0.0 2.1 2.2 2.9 0.6 2.4 1.5 0.5
Smoking status: Current 2.7 4.3 6.7 -2.3 2.6 2.5 1.0 -2.2 2.6 1.8 -0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.4 3.0 9.8 0.8 -1.7 -1.6 -1.7 3.1 -2.2 -0.3 -0.2
Whole body water mass 2.1 12.1 21.3 -2.5 4.6 4.6 3.3 -0.7 4.5 1.1 3.9
Leg predicted mass (right) 1.5 7.8 14.7 -1.9 3.8 3.8 2.2 -0.2 3.7 0.9 3.3
Arm fat mass (left) 0.1 0.3 0.8 -0.3 0.4 0.4 -0.9 -0.7 0.2 0.8 0.2
Number of self-reported non-cancer illnesses 4.0 6.9 10.8 1.8 -3.3 -3.3 -2.8 -0.9 -3.1 -1.9 -3.0
Average weekly champagne plus white wine intake 0.6 0.9 2.3 -0.8 0.7 0.7 -0.2 -1.1 0.8 -1.5 1.0
Miserableness 0.3 0.6 2.1 -1.0 0.3 0.3 -0.4 1.4 0.1 1.0 -0.1
Guilty feelings 0.5 0.7 2.6 -1.6 -0.3 -0.3 0.2 -0.3 -0.6 -0.4 1.5
Wears glasses or contact lenses 0.7 0.9 4.3 -0.9 0.3 0.3 0.2 -1.0 -0.0 0.7 2.1
Ever taken oral contraceptive pill 0.3 0.4 2.1 -0.7 0.2 0.2 -0.3 0.3 0.3 -1.4 0.4
Hearing aid user 1.0 1.1 1.7 -1.3 1.2 1.2 1.0 -0.9 1.3 0.7 -0.3
Mother’s age at death 0.9 1.1 2.3 -1.2 1.2 1.1 0.4 -1.3 1.5 -0.2 0.4
Financial situation satisfaction 0.3 0.3 2.0 0.0 -0.2 -0.2 0.2 1.4 -0.2 0.5 0.3
Tinnitus: Yes, now most or all of the time 2.0 2.4 4.0 1.4 -1.8 -1.8 -2.0 0.2 -1.9 -1.6 0.3
Commuting to job workplace: Public transport 1.1 1.3 4.1 -0.2 0.4 0.4 1.7 1.2 0.4 1.1 2.0
Eye problems/disorders: Glaucoma 0.4 0.4 1.1 0.1 0.9 0.9 0.3 0.1 1.0 -0.2 -0.8
Medication: Blood pressure 0.5 0.9 5.8 0.1 -0.4 -0.5 0.4 -2.4 -0.9 -0.1 0.1
Pain type(s) experienced in last month: Hip pain 0.7 0.9 3.6 -1.1 0.7 0.6 0.9 -0.6 0.7 1.9 -0.3
Supplements: Fish oil (including cod liver oil) 1.5 1.9 3.8 -1.9 1.4 1.3 1.2 -1.8 1.2 1.3 0.6
High cholesterol (Self-reported) 116.0 205.7 357.2 11.8 -18.9 -18.7 -13.9 5.3 -18.5 -12.8 -8.5
Medication: Bendroflumethiazide 1.3 2.0 7.4 -1.8 1.0 1.0 1.1 -2.7 0.6 1.1 0.9
Medication: Paracetamol 0.4 0.7 2.5 1.0 -0.6 -0.5 -0.3 1.0 -0.3 -1.6 -0.3
Medication: Lisinopril 1.1 1.4 2.3 1.2 -1.5 -1.4 -0.7 0.4 -1.4 -1.1 1.1
Medication: Atorvastatin 55.5 68.6 118.8 7.2 -10.9 -10.8 -8.1 3.9 -10.9 -6.2 -4.8
Illnesses of father: High blood pressure 1.1 1.4 4.0 1.6 -0.7 -0.7 -1.4 0.9 -0.8 -2.0 0.5
Alcohol drinker status: Never 0.6 0.7 2.9 0.0 0.9 0.8 0.6 -1.7 0.9 -0.2 -0.2
Ever smoked 1.0 1.8 8.0 -0.9 0.9 0.8 1.3 -1.5 0.7 0.3 2.8
Basal metabolic rate 1.7 9.2 16.8 -2.1 4.0 4.1 2.7 -0.7 4.0 1.1 3.3
Leg fat percentage (left) 0.3 1.1 2.3 0.3 -1.0 -1.1 -1.1 -1.3 -1.1 0.7 -1.5
Arm fat-free mass (left) 2.0 10.0 17.0 -2.2 4.1 4.1 3.1 -1.0 4.0 1.7 3.4
Number of operations (self-reported) 0.7 1.0 2.4 1.6 -0.9 -0.9 -1.1 0.3 -0.5 -1.1 -1.2
Average weekly beer plus cider intake 0.3 0.4 1.8 -0.3 0.0 0.0 0.4 0.8 0.1 1.0 -1.4
Irritability 0.1 0.2 0.5 -0.6 -0.2 -0.2 -0.0 -0.4 -0.1 -0.7 0.4
Risk taking 2.6 3.8 6.1 -1.1 2.3 2.3 2.5 -1.9 2.1 1.6 1.5
Ever had prostate specific antigen (PSA) test 0.1 0.2 0.7 0.3 0.0 -0.0 -0.3 -0.9 0.1 0.6 0.2
Fractured/broken bones in last 5 years 0.1 0.2 0.6 0.7 -0.1 -0.1 0.2 -0.6 0.1 -0.1 -0.5
Age started oral contraceptive pill 1.1 1.4 4.5 -1.0 0.8 0.7 1.8 -2.1 0.7 1.0 -0.2
Diastolic blood pressure, automated reading 0.8 2.5 6.2 -2.5 1.7 1.6 1.1 -0.1 1.4 1.2 1.8
Ever depressed for a whole week 1.6 2.0 6.5 0.5 -1.1 -1.0 -1.6 1.9 -0.8 -2.5 -0.5
Unable to work because of sickness or disability 1.3 1.7 4.2 0.9 -1.8 -1.8 -1.2 -0.6 -2.1 0.1 -0.2
Commuting to job workplace: Cycle 0.8 1.0 4.3 0.6 0.6 0.7 1.4 0.5 0.7 -0.3 2.1
Myopia 0.3 0.4 1.3 -0.5 0.6 0.7 0.3 0.1 0.6 -0.8 1.2
Vascular/heart problems diagnosed by doctor 0.5 1.3 4.9 -0.5 1.1 1.2 0.1 2.2 1.6 0.1 -0.6
Cholesterol lowering medication 51.8 76.3 132.2 7.0 -11.5 -11.4 -8.6 2.8 -11.4 -6.9 -6.2
Medication: Omeprazole (e.g. Zanprol) 0.7 0.8 1.3 0.1 -1.1 -1.1 -1.0 -0.2 -1.1 -0.9 -1.0
Pain experienced in last month 0.3 0.5 2.5 0.8 0.1 0.1 0.6 0.2 -0.2 -0.7 1.6
Supplements: Calcium 0.6 0.6 1.8 -0.4 -0.6 -0.6 -1.2 1.4 -0.9 0.1 0.2
Basal cell carcinoma (self-reported) 0.2 0.2 1.1 -0.7 0.2 0.2 0.1 1.1 -0.2 0.1 -0.0
Heart attack/myocardial infarction (self-reported) 18.3 23.6 31.1 5.3 -5.6 -5.5 -5.2 1.4 -5.5 -4.8 -4.0
Deep venous thrombosis (DVT) (self-reported) 0.8 1.0 2.2 -1.0 0.9 0.9 1.5 0.7 1.1 1.1 0.4
Heart disease (siblings) 5.8 7.1 13.2 1.9 -3.6 -3.6 -2.5 1.5 -3.5 -1.2 -2.3
Alcohol drinker status: Previous 2.8 3.2 5.9 1.8 -2.4 -2.4 -1.1 -0.0 -1.9 -2.3 -0.3
Pack years of smoking 0.7 1.0 2.3 1.5 0.5 0.6 0.3 -1.1 0.6 1.3 -1.4
Impedance of whole body 2.1 10.5 40.3 2.3 -3.4 -3.5 -1.9 0.3 -3.2 0.6 -6.3
Leg fat mass (left) 0.0 0.2 0.6 -0.1 0.4 0.4 -0.4 -0.8 0.3 0.6 0.0
Arm predicted mass (left) 2.3 11.5 19.9 -2.4 4.4 4.5 3.4 -0.6 4.4 1.6 3.6