Hub : Genes

SORT1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Mucosa	0.2000	0.0650	2.0e-04	0.068	NA	0.037	NA	0.044	2.6e-05	NA	1.7e-03	NA	6.7e-04
2	GTEx	Testis	0.2490	0.0680	4.2e-06	0.169	NA	0.122	NA	0.170	5.6e-08	NA	4.7e-06	NA	5.2e-08
3	NTR	Blood	0.0494	0.0125	5.3e-14	0.057	0.045	0.048	0.049	0.056	1.0e-17	1.9e-14	3.1e-15	1.9e-15	2.1e-17
4	TCGA	Liver Hepatocellular Carcinoma	0.2310	0.0750	4.5e-06	0.160	0.149	0.141	NA	0.162	5.5e-08	1.7e-07	3.6e-07	NA	4.6e-08
5	TCGA	Stomach Adenocarcinoma	0.0410	0.0260	7.0e-03	0.011	0.027	-0.001	NA	0.006	5.1e-02	4.4e-03	3.5e-01	NA	1.1e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	2.4	3.8	5.7	-1.6	2.3	2.4	0.9	2.1
Bipolar Disorder or Schizophrenia	0.4	0.9	1.8	-0.4	1.1	1.4	0.8	0.9
Depressed Affect (Nagel 2018)	0.5	1.1	3.0	1.0	-0.5	0.3	1.7	1.1
Depression (Nagel 2018)	0.4	0.6	1.3	0.6	-0.4	1.1	0.4	1.1
Intelligence (Savage-Jansen 2018)	6.7	20.6	41.9	-4.5	4.9	6.5	0.1	4.1
Neuroticism (Nagel 2018)	1.0	2.3	4.1	-1.0	1.5	2.0	1.1	1.8
Schizophrenia (2018)	0.1	0.3	0.6	0.8	-0.5	-0.2	0.4	-0.5
Schizophrenia vs Biploar Disorder	1.3	1.7	2.8	1.2	-1.5	-1.5	-0.1	-1.7
Worry (Nagel 2018)	0.7	1.4	2.5	-1.2	1.6	1.6	-0.1	0.8
Alzheimer’s Disease (in mother)	0.3	0.3	0.6	-0.7	0.5	0.1	-0.8	-0.4
Alzheimer’s Disease (in father)	0.8	0.8	2.0	0.6	-0.9	-1.4	1.0	0.1
Alzheimer’s Disease (including proxy)	0.1	0.1	0.4	0.1	-0.3	-0.6	0.3	0.1
Crohns Disease (2017)	1.1	2.4	6.9	-2.6	1.9	0.8	-0.7	0.5
Irritable Bowel Disease (IBD)	0.7	1.7	4.3	-2.1	1.9	0.6	-0.6	0.1
Ulcerative Colitis (UC)	0.5	1.0	2.4	-1.4	1.5	0.5	-0.6	-0.1
Major Depression (MDD)	1.4	1.7	3.0	-0.9	1.0	1.7	1.0	1.6
Reaction Time	0.6	1.2	1.8	1.3	-1.3	-1.0	1.2	0.2
Verbal and Numeric Reasoning (VNR)	5.8	13.9	30.7	-3.4	3.9	5.5	-0.2	3.5
Breast Cancer	1.4	3.4	7.6	2.8	-1.9	-1.9	0.7	-1.2
Ovarian Cancer	0.1	0.2	0.4	0.1	0.2	-0.6	0.6	-0.1
Prostate Cancer	0.2	0.3	0.6	0.7	-0.8	0.3	-0.3	-0.0
Age at First Birth	1.4	2.1	3.9	-1.1	2.0	1.3	1.1	1.6
Bipolar Disorder (2011)	0.3	0.3	1.4	0.0	0.0	0.0	0.0	1.2
Body Mass Index (BMI) (2010)	1.6	2.2	4.8	1.2	-1.5	0.0	2.2	1.5
Coronary Artery Disease (CAD)	5.6	6.7	27.9	-1.4	-0.6	-1.8	0.0	-5.3
Crohns Disease (2012)	1.3	2.1	5.0	-2.2	1.5	0.4	-1.6	-0.8
Mean Putamen Volume	0.6	0.7	1.8	-0.6	-0.2	-0.9	-0.9	-1.3
Fasting Glucose	2.3	2.8	5.5	-0.2	0.8	1.6	2.3	2.3
HbA1C	0.1	0.1	0.4	-0.3	0.3	0.2	-0.1	0.6
HDL Cholesterol	5.9	9.8	29.7	-0.6	1.7	1.2	5.5	3.8
LDL Cholesterol	159.4	252.2	739.8	-5.8	-2.8	-8.2	-27.2	-20.3
Lupus	0.8	1.2	2.4	-1.1	1.3	1.5	-0.1	0.9
Neuroticism (2016)	0.1	0.2	0.5	-0.5	0.4	0.2	-0.7	-0.2
Primary Biliary Cirrhosis	0.3	0.5	1.2	1.1	-1.0	-0.5	0.1	-0.1
Rheumatoid Arthritis	1.0	1.4	2.4	-1.6	1.1	-0.3	-1.1	-1.4
Schizophrenia (2014)	0.1	0.2	0.4	0.6	-0.5	-0.1	0.2	-0.4
Triglycerides	0.9	1.5	3.1	0.1	-1.4	-0.7	-1.8	-1.4
Type 2 Diabetes (T2D) (2012)	3.3	3.8	6.3	2.3	-1.7	0.3	2.5	2.0
Ulcerative Colitis	0.4	0.6	1.5	0.2	-0.2	-0.7	-0.9	-1.2
Blood Eosinophil Count	0.4	3.0	5.3	-2.3	1.7	2.0	-1.7	0.6
Blood Platelet Count	0.4	4.7	9.1	2.5	-3.0	-2.6	0.5	-1.1
Blood Red Count	1.4	13.5	21.6	-4.3	4.7	4.2	0.6	3.1
Blood White Count	0.5	3.6	6.9	2.1	-1.3	0.5	2.6	2.2
Heel T-Score	1.8	13.9	27.4	-1.0	2.5	4.0	4.4	5.2
BMI	2.2	12.5	31.8	-2.4	2.5	5.6	0.5	4.4
Height	0.9	16.5	55.2	3.6	-1.4	-1.0	7.4	3.3
Waist Hip Ratio (WHR)	0.7	2.9	7.0	-0.6	1.1	0.7	2.6	2.3
Systolic Blood Pressure	0.5	2.6	6.9	-2.6	1.7	0.7	-1.6	0.1
Smoking Status	1.7	4.1	11.0	1.4	-0.8	1.0	3.3	2.4
Allergy or Eczema	0.9	2.5	4.0	-1.8	2.0	1.1	1.1	1.6
Cardiovascular Disease	9.9	32.8	108.2	-4.4	1.7	-0.3	-10.4	-5.8
Hypothyroidism (self reported)	0.6	1.3	3.2	-1.8	1.3	1.1	-0.5	0.2
Respiratory disease	2.5	5.5	9.8	-1.4	2.3	3.1	1.7	2.8
Type 2 Diabetes (T2D) (2018)	0.3	0.7	1.3	0.6	-0.3	0.6	1.1	1.1
Lung FEV1/FVC ratio	1.3	6.5	23.9	-1.4	-0.5	0.1	-4.9	-2.5
Lung FVC	0.1	0.5	1.8	0.5	0.3	-0.3	1.3	0.2
Neuroticism	1.5	3.5	7.1	-1.1	1.7	2.7	1.2	2.2
Chronotype (morning person)	1.4	3.2	7.1	-2.7	2.4	0.7	-1.4	-0.5
Hair Pigment	0.1	2.8	6.4	2.1	-2.5	-1.6	0.1	-0.7
Tanning	0.4	4.4	6.2	-1.6	2.5	1.2	2.5	2.4
Hand grip strength (left)	0.5	1.2	4.5	0.3	0.5	0.4	2.1	1.1
Number of treatments/medications taken	5.2	9.4	28.9	-2.4	0.6	-0.2	-5.4	-3.4
Average weekly spirits intake	0.1	0.1	0.2	0.2	-0.3	0.0	0.3	0.5
Sensitivity / hurt feelings	2.4	4.1	8.8	-1.6	2.0	3.0	0.9	2.1
Frequency of depressed mood in last 2 weeks	0.4	0.5	1.3	0.3	0.1	1.0	0.6	1.1
Hearing difficulty/problems: Yes	2.2	3.3	9.4	2.0	-1.0	-0.1	3.1	1.5
Relative age of first facial hair	0.3	0.6	1.6	0.8	-0.4	-1.3	0.0	-0.9
Other serious medical condition/disability diagnosed by doctor	2.5	3.2	10.3	-0.9	0.1	-0.2	-3.2	-2.2
Ever used hormone-replacement therapy (HRT)	1.0	1.3	3.2	1.0	-0.9	-1.1	1.8	0.4
Ever had hysterectomy (womb removed)	0.5	0.6	0.9	0.9	-0.6	-0.8	0.1	-1.0
Systolic blood pressure, automated reading	0.6	1.8	3.1	-1.2	1.1	1.6	0.4	1.8
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.3	0.1	0.2	0.5	0.0	0.6
Angina	10.6	14.0	48.5	-1.8	0.2	-0.5	-7.0	-4.2
Medication for hormone replacement therapy	0.0	0.0	0.1	-0.1	0.1	-0.2	-0.0	-0.3
Vitamin and mineral supplements	0.6	0.8	1.6	0.5	-0.9	-1.3	-0.5	-1.1
Supplements: Zinc	1.0	1.1	1.8	-1.0	1.0	1.3	0.9	1.1
Medication: Co-codamol	0.7	0.8	1.6	0.4	-0.7	-0.9	-0.9	-1.3
Medication: Metformin	1.0	1.4	3.2	1.4	-1.8	-0.8	1.0	0.2
Diabetes (father)	2.4	3.0	8.7	1.7	-0.9	-1.4	2.9	0.8
Diabetes (mother)	1.8	2.4	4.7	2.2	-1.2	-0.2	2.2	0.9
Severe depression (siblings)	0.2	0.2	0.4	-0.4	0.3	0.1	-0.7	-0.6
Pack years adult smoking proportion	3.3	5.0	7.9	2.3	-2.7	-2.8	-0.3	-2.2
Impedance of leg (right)	7.7	37.3	69.4	4.8	-6.0	-8.3	-2.9	-7.0
Leg fat-free mass (left)	2.2	11.8	21.4	-1.3	2.3	4.5	3.2	4.6
Trunk fat percentage	0.7	2.8	7.6	2.1	-2.8	-0.9	-0.9	-0.7
Hand grip strength (right)	0.4	1.1	4.5	0.6	0.1	-0.2	2.1	0.8
Townsend deprivation index at recruitment	1.2	1.7	4.5	-0.9	1.4	2.1	-1.1	0.4
Current tobacco smoking	2.8	4.5	7.0	2.6	-2.5	-1.8	2.5	0.4
Average weekly fortified wine intake	1.2	1.4	2.2	-0.7	1.1	1.4	1.0	1.5
Maternal smoking around birth	0.8	1.2	3.0	0.2	-0.7	-0.8	-1.7	-1.4
Fed-up feelings	1.2	2.1	5.1	1.3	-0.6	0.6	2.3	1.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.3	0.7	-0.1	-0.2	0.9	-0.9	0.4
Relative age voice broke	1.5	2.3	3.8	-1.6	1.7	1.9	-0.1	1.5
Taking other prescription medications	0.7	1.1	2.2	-1.1	0.5	1.5	-1.3	-0.0
Age when periods started (menarche)	0.8	1.9	2.6	1.6	-1.6	-1.3	-0.7	-1.4
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.5	0.0	-0.3	-0.6	-0.2	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.2	2.6	-0.4	0.7	1.1	1.2	1.6
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	2.0	1.4	-1.0	-0.4	0.2	0.1
Qualifications: CSEs or equivalent	2.1	2.7	6.4	-0.2	-0.7	-1.5	-2.5	-2.2
Serious illness, injury or assault to yourself	3.5	4.2	6.3	0.8	-1.9	-2.0	-2.5	-2.5
High blood pressure	0.8	2.2	5.0	-1.1	1.3	1.7	0.7	2.2
Hayfever, allergic rhinitis or eczema	0.7	1.6	3.6	-1.9	1.8	0.8	0.3	0.7
Multivitamins +/- minerals	2.7	3.4	6.3	-2.5	2.5	1.9	0.1	0.9
Stomach or abdominal pain in last month	3.3	4.1	5.7	2.4	-2.1	-2.4	-0.4	-2.1
Supplements: Glucosamine	2.6	3.3	5.9	-0.9	1.1	2.2	2.4	2.0
Diverticular disease/diverticulitis (self-reported)	1.0	1.1	2.2	-1.3	1.5	1.3	-0.2	0.2
Medication: Atenolol	2.5	3.1	9.0	-1.8	0.2	-0.4	-3.0	-1.8
Medication: Levothyroxine sodium	0.1	0.2	0.5	-0.7	0.3	0.1	-0.5	-0.1
Sitting height	0.1	0.9	2.7	0.9	-0.4	-0.2	1.6	0.9
Chronic bronchitis/emphysema (father)	0.3	0.4	1.1	-0.8	1.0	0.4	-0.3	-0.1
High blood pressure (mother)	1.8	2.5	4.5	-1.7	1.3	1.8	-2.1	-0.0
Body mass index (BMI)	1.2	5.1	13.5	-1.4	1.3	3.7	0.2	2.9
Impedance of leg (left)	8.1	39.3	73.8	5.3	-6.5	-8.6	-2.6	-6.8
Leg predicted mass (left)	2.3	12.0	21.9	-1.2	2.3	4.5	3.3	4.7
Trunk fat mass	0.3	1.2	2.4	1.4	-1.6	0.6	0.4	1.0
Waist circumference	1.1	4.1	9.8	-0.2	0.7	2.8	1.6	3.1
Number of incorrect matches in round	0.1	0.2	0.7	0.9	-0.3	-0.2	0.5	0.3
Past tobacco smoking	0.6	1.0	2.4	0.3	-0.7	-1.6	-0.3	-1.4
Alcohol usually taken with meals	0.2	0.3	0.6	-0.7	0.4	0.3	-0.8	-0.3
Nervous feelings	0.7	1.3	2.0	-1.2	1.3	1.4	0.2	1.0
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.9	-0.1	-0.4	-0.3	-1.4	-0.6
Hearing difficulty/problems with background noise	1.9	3.0	7.6	2.8	-2.1	-0.0	1.6	0.7
Hair/balding pattern: Pattern 2	0.4	0.6	1.2	-0.7	1.1	1.0	0.3	0.4
Had menopause	1.4	1.7	5.8	1.4	-0.5	-0.3	2.4	0.9
Had other major operations	0.1	0.2	0.4	0.7	-0.3	0.4	0.0	0.3
Forced vital capacity (FVC)	0.1	0.3	0.6	-0.1	0.1	-0.8	0.3	-0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.4	3.2	0.1	0.4	1.0	1.7	1.8
Ever unenthusiastic/disinterested for a whole week	1.5	1.8	4.5	0.2	-0.7	-0.7	-2.1	-1.9
Qualifications: None of the above	5.4	11.7	18.9	4.2	-4.3	-4.3	0.6	-1.7
Financial difficulties in last 2 years	1.2	1.6	2.3	-1.5	1.2	1.5	-1.4	-0.1
Mouth/teeth dental problems	0.2	0.4	0.7	-0.4	0.8	0.3	0.8	0.4
Heart attack	7.2	9.3	28.7	-2.2	0.4	-0.6	-5.4	-3.5
Allergy	0.5	1.2	2.0	1.4	-1.4	-0.9	-0.6	-1.1
Pain all over the body in last month	0.5	0.5	1.5	-0.2	0.3	0.9	-1.2	-0.1
Diabetes (self-reported)	0.3	0.4	1.1	0.7	-1.0	-0.1	0.4	0.5
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.3	-0.9	1.1	0.4	0.6	0.2
Medication: Ramipril	2.5	3.2	6.0	-2.5	1.4	-0.9	-2.2	-1.6
Medication: Simvastatin	28.9	42.4	139.2	-4.1	0.8	-1.8	-11.8	-7.2
Fluid intelligence score	5.5	11.4	24.5	-3.2	3.6	5.0	-0.0	3.0
Illnesses of siblings	0.8	1.2	3.6	-0.5	0.8	0.4	1.9	1.1
Neuroticism score	1.3	2.6	4.5	-0.8	1.4	2.1	1.3	2.1
Weight	1.1	5.3	12.3	0.2	0.4	2.8	2.4	3.5
Impedance of arm (right)	6.6	31.0	48.0	4.9	-6.2	-6.9	-2.7	-6.1
Arm fat percentage (right)	0.3	1.0	2.5	1.0	-1.6	0.8	-1.0	0.3
Trunk fat-free mass	3.2	18.1	34.0	-1.3	2.9	4.5	5.1	5.8
Hip circumference	0.2	1.0	1.5	1.1	-1.1	1.2	0.2	1.2
Time employed in main current job	0.6	0.6	1.1	0.5	-0.6	-1.1	-0.8	-0.9
Alcohol intake versus 10 years previously	2.5	3.7	4.9	-1.7	2.1	2.2	1.4	2.0
Father’s age at death	8.7	11.7	22.3	-0.8	2.2	3.1	4.7	4.6
Worrier / anxious feelings	0.6	1.2	3.1	0.3	0.1	0.8	1.8	1.4
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	2.2	-1.5	1.1	1.0	-1.1	0.2
Falls in the last year	2.9	4.0	7.0	2.6	-2.7	-2.2	-0.0	-1.2
Hair/balding pattern: Pattern 3	1.2	1.8	3.8	-1.9	1.9	0.9	0.6	0.3
Number of live births	3.1	4.3	7.9	2.8	-2.7	-2.4	1.0	-0.4
Forced expiratory volume in 1-second (FEV1)	0.3	0.8	2.2	-0.3	-0.1	-0.9	-1.1	-1.5
Pulse rate	1.3	2.3	4.6	-1.8	1.1	-0.6	-2.1	-1.4
Happiness	0.2	0.2	0.4	-0.4	0.7	0.5	0.0	0.6
Noisy workplace	3.7	4.6	7.8	2.5	-2.5	-2.8	1.4	-0.7
Qualifications: A levels/AS levels or equivalent	1.8	4.1	7.5	-2.7	2.7	2.2	-0.6	0.6
Serious illness, injury or assault of a close relative in last 2 years	2.1	2.4	4.7	-2.2	2.0	1.1	-1.4	-0.1
Mouth/teeth dental problems: Dentures	0.3	0.4	0.9	-0.5	0.4	0.5	0.7	1.0
Asthma	1.4	2.8	5.2	-1.8	2.3	2.2	-0.1	1.0
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.6	0.6	-0.8	-0.2	0.2	-0.7
Medication: Cholesterol lowering	44.7	69.5	219.0	-5.5	1.1	-2.5	-14.8	-9.5
Depression (self-reported)	0.7	0.8	2.2	1.5	-1.3	-0.3	0.4	0.4
Medication: Lansoprazole	1.5	1.7	2.6	1.6	-1.5	-1.6	0.3	-1.0
Prospective memory result	1.0	1.2	4.8	0.4	0.3	0.3	2.2	1.0
Lung cancer (father)	2.4	2.8	4.4	2.1	-1.9	-1.6	1.8	0.0
Illnesses of mother	2.9	3.6	6.7	2.5	-2.6	-1.8	1.4	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.0	0.0	0.1	-0.1	0.3	0.3	-0.1	-0.1
Pulse wave Arterial Stiffness index	0.7	0.8	2.2	1.1	-1.5	-0.8	0.1	-0.0
Impedance of arm (left)	5.0	22.9	36.7	3.9	-5.1	-6.1	-2.7	-5.4
Arm fat mass (right)	0.5	2.2	5.1	0.3	-0.3	2.3	0.7	2.2
Trunk predicted mass	3.2	18.4	34.5	-1.3	3.0	4.6	5.0	5.9
Standing height	0.9	9.1	27.2	3.2	-1.7	-1.3	5.2	2.0
Length of working week for main job	2.5	2.8	4.3	-2.0	1.9	2.1	-1.1	0.9
Exposure to tobacco smoke at home	1.0	1.2	2.1	1.4	-1.4	-0.6	-0.7	-0.8
Breastfed as a baby	1.3	1.7	3.5	-0.6	1.0	1.0	1.9	1.5
Tense / ‘highly strung’	1.2	2.0	2.9	-1.7	1.5	1.6	-1.5	-0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.5	1.1	-0.7	0.7	0.8	-1.0	-0.4
Hair/balding pattern: Pattern 4	0.2	0.4	0.6	0.7	-0.8	-0.6	-0.6	-0.4
Birth weight of first child	4.2	7.6	12.0	-3.2	3.5	2.8	1.2	2.6
Peak expiratory flow (PEF)	1.2	2.8	6.1	0.8	-1.4	-1.9	-1.5	-2.5
Pulse wave reflection index	0.7	0.8	1.5	1.2	-1.0	-0.3	0.9	0.8
Ever highly irritable/argumentative for 2 days	0.6	0.7	1.5	-0.3	0.6	1.2	0.4	1.2
Loud music exposure frequency	0.1	0.2	0.6	0.8	-0.4	-0.1	0.1	-0.0
Qualifications: O levels/GCSEs or equivalent	1.8	2.9	5.0	-2.2	2.1	2.0	-1.1	-0.0
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	1.8	0.8	-1.2	-0.9	-1.4	-1.2
Blood clot in the leg (DVT)	0.2	0.3	0.7	0.9	-0.4	-0.0	0.5	0.4
Medication: Paracetamol	0.8	1.4	2.9	1.5	-1.7	-0.7	-0.6	-1.0
Headache pain in last month	0.8	1.4	3.1	0.6	-0.5	-1.2	-1.4	-1.8
Medication for cholesterol, blood pressure or diabetes	14.6	24.2	73.3	4.4	-1.8	0.6	8.6	5.0
Glaucoma (self-reported)	0.5	0.6	1.2	-0.6	0.8	0.6	1.1	0.7
Gout (self-reported)	1.3	1.7	4.8	0.5	0.5	0.6	2.2	1.7
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.7	-0.8	0.6	0.4	0.1	0.0
Medication: Amlodipine	0.8	1.1	2.6	-1.0	0.0	-0.5	-1.6	-1.3
Medication: Ventolin 100micrograms inhaler	2.9	3.8	5.6	-1.1	2.0	2.4	1.7	2.2
Birth weight	1.9	4.1	6.7	-2.6	2.6	2.3	-1.3	0.6
Chronic bronchitis/emphysema (mother)	0.9	1.1	2.1	-0.6	0.4	-1.2	-1.1	-1.4
High blood pressure (siblings)	1.2	1.8	6.4	-1.0	0.3	0.4	-2.5	-1.1
Forced vital capacity (FVC), Best measure	0.1	0.4	1.3	0.1	0.4	0.3	1.2	0.7
Body fat percentage	0.7	2.7	7.2	1.9	-2.7	-0.7	-1.1	-0.7
Leg fat percentage (right)	0.7	2.4	6.3	1.8	-2.5	-0.8	-1.1	-0.9
Arm fat-free mass (right)	2.9	15.1	29.4	-1.1	2.6	4.4	4.4	5.4
Exposure to tobacco smoke outside home	2.0	2.7	5.4	2.3	-2.3	-1.4	0.9	0.4
Comparative body size at age 10	2.4	6.5	15.4	-1.8	1.9	3.9	0.3	3.2
Number of full brothers	5.4	6.8	14.0	3.7	-3.4	-2.3	-0.1	-1.8
Worry too long after embarrassment	0.6	1.0	2.3	0.4	-0.1	0.9	1.4	1.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.2	-0.3	0.5	0.5	-0.1	0.1
Wheeze or whistling in the chest in last year	0.7	1.2	1.8	-0.2	1.2	1.3	1.3	1.0
Number of children fathered	1.0	1.1	2.5	0.7	-1.0	-1.6	-0.3	-1.2
Reason for reducing amount of alcohol drunk: Health precaution	2.7	3.1	6.2	-2.4	2.5	1.6	-0.8	0.6
Age at first live birth	1.1	2.0	4.7	-2.2	1.9	0.5	0.6	1.0
Pulse wave peak to peak time	0.7	0.8	2.2	-0.9	1.5	0.9	0.2	0.3
Health satisfaction	0.8	1.0	3.3	-0.4	-0.2	-0.1	-1.8	-1.2
Shortness of breath walking on level ground	0.6	0.7	1.0	1.0	-0.8	-0.5	-0.8	-0.9
Qualifications: College or University degree	4.9	15.5	25.7	-3.8	4.5	5.1	1.5	3.9
Eye problems/disorders: None of the above	0.5	0.6	1.0	-0.8	0.9	1.0	0.0	0.7
Mouth/teeth dental problems: Loose teeth	0.9	1.1	2.0	-1.4	1.2	1.0	-0.9	0.1
Emphysema/chronic bronchitis	0.1	0.1	0.1	-0.2	0.1	-0.3	0.2	0.3
Medication for pain relief, constipation, heartburn	3.3	5.6	12.8	-0.3	1.3	1.1	3.6	3.5
Neck or shoulder pain in last month	7.0	10.0	15.8	2.3	-3.1	-3.6	-2.5	-4.0
Medication: Blood pressure	2.7	4.7	10.8	-3.3	2.5	1.5	-2.0	-0.1
Angina (self-reported)	11.6	15.3	53.0	-1.9	-0.0	-0.8	-7.3	-4.4
Migraine (self-reported)	1.0	1.3	3.7	-0.4	-0.1	-0.5	-1.9	-1.5
Medication: Ibuprofen	0.1	0.1	0.4	0.4	-0.3	-0.0	0.1	-0.7
Medication: Allopurinol	1.7	2.2	3.3	-0.7	1.5	1.6	1.6	1.8
Medication: Omeprazole	0.5	0.6	1.3	0.5	-1.0	-0.1	-1.1	-0.7
Medication: Seretide 50 evohaler	1.1	1.3	3.8	0.2	-0.1	0.1	1.9	1.6
Mean time to correctly identify matches	1.4	2.6	5.5	1.9	-1.6	-1.0	2.3	0.9
Heart disease (mother)	1.0	1.2	3.3	-0.8	0.6	-0.4	-1.8	-1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.7	1.1	0.1	-0.0	-1.1	-1.0	-1.0
Whole body fat mass	0.3	1.3	2.6	1.4	-1.6	0.7	0.5	1.0
Leg fat mass (right)	0.2	0.9	1.4	1.0	-1.2	1.0	0.3	1.0
Arm predicted mass (right)	3.0	15.4	29.7	-1.3	2.8	4.4	4.3	5.5
Pulse rate, automated reading	2.1	6.7	15.3	-1.0	-0.3	-2.1	-3.9	-3.6
Alcohol intake frequency.	0.8	1.8	3.3	-1.5	1.8	1.5	-0.7	0.7
Comparative height size at age 10	1.1	6.3	19.8	2.3	-1.3	-0.9	4.5	2.0
Number of full sisters	1.0	1.2	2.7	1.0	-1.3	-1.7	-0.4	-0.7
Suffer from ‘nerves’	0.2	0.4	0.9	0.3	-0.6	-0.9	-0.4	-0.6
Overall health rating	0.2	0.5	1.9	-0.2	-0.2	0.4	-1.4	-0.4
Chest pain or discomfort	3.1	4.4	8.4	0.7	-1.5	-1.7	-2.9	-2.8
Had major operations	0.9	1.0	3.0	-0.6	-0.2	-0.5	-1.7	-1.2
Age at last live birth	1.6	2.3	6.0	-2.4	2.0	0.9	-0.5	0.8
Family relationship satisfaction	0.5	0.6	1.1	-0.6	1.1	1.0	-0.8	-0.0
Leg pain on walking	2.4	3.0	6.2	2.4	-2.5	-1.6	0.9	-0.4
Qualifications: NVQ or HND or HNC or equivalent	1.9	2.2	4.2	1.0	-1.3	-1.9	-0.8	-2.0
Commuting to job workplace: Car/motor vehicle	1.6	1.8	3.0	1.1	-1.7	-1.7	-0.5	-1.3
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	1.5	1.1	-1.1	-0.9	1.2	0.4
Medication: Aspirin	9.0	11.9	34.2	-1.4	-0.3	-1.6	-5.8	-4.5
Supplements: Vitamin C	1.8	2.1	5.1	1.3	-0.4	0.6	2.3	1.8
Knee pain experienced in last month	0.7	1.1	2.8	1.3	-1.7	-0.8	0.7	-0.1
Hypertension (Self-reported)	0.6	1.7	3.2	-1.2	1.3	1.4	0.0	1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.7	0.2	-0.6	-1.3	0.0	-0.6
Illnesses of father: Heart disease	10.4	14.4	36.8	-4.6	2.4	0.9	-6.1	-2.7
Illnesses of siblings: Diabetes	2.5	3.1	6.4	2.5	-2.0	-1.8	1.4	0.0
Smoking status: Previous	1.7	2.5	5.4	-1.4	1.8	2.3	-0.3	1.3
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.2	4.5	0.7	0.2	0.2	2.1	0.9
Whole body fat-free mass	3.0	17.2	32.5	-1.3	2.8	4.8	4.6	5.7
Leg fat-free mass (right)	2.6	13.9	26.4	-1.3	2.5	4.7	3.7	5.1
Arm fat percentage (left)	0.2	0.9	1.5	0.6	-1.1	1.2	-0.8	0.7
Average weekly red wine intake	1.4	2.0	4.1	0.1	-1.2	-1.0	-1.9	-2.0
Handedness (chirality/laterality): Left-handed	0.7	0.8	2.0	-0.7	1.2	1.4	0.2	0.4
Mood swings	1.1	2.1	4.8	-0.3	0.8	1.3	1.7	2.2
Loneliness, isolation	0.2	0.2	0.5	0.6	-0.7	0.3	0.4	0.2
Long-standing illness, disability or infirmity	0.6	0.9	2.5	0.6	-0.8	0.0	-1.6	-1.0
Ever had bowel cancer screening	0.1	0.1	0.3	-0.3	0.2	0.5	-0.4	0.2
Diabetes diagnosed by doctor	0.2	0.3	0.6	0.6	-0.8	0.4	-0.0	0.5
Ever had stillbirth, spontaneous miscarriage or termination	2.4	2.6	5.3	2.3	-2.0	-1.3	1.2	0.4
Friendships satisfaction	0.4	0.5	1.2	-1.1	0.6	0.5	-0.8	-0.2
Qualifications: nursing, teaching	1.1	1.7	3.1	-1.4	1.8	1.7	-0.7	0.2
Commuting to job workplace: Walk	2.9	3.1	4.7	-2.0	2.1	1.6	-2.2	-0.1
Eye problems/disorders: Cataract	0.8	0.9	1.8	1.0	-1.4	-1.2	0.2	-0.4
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	1.6	0.5	-0.8	-1.2	-0.9	-1.3
Medication for cholesterol	5.9	8.9	27.1	1.5	0.5	1.5	5.2	3.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	0.7	-0.9	0.3	0.7	0.3	0.8
Back pain experienced in last month	2.8	4.0	8.1	2.2	-2.9	-2.4	0.2	-1.2
Mineral and other dietary supplements	0.3	0.4	1.2	0.5	-0.4	-0.6	-1.1	-0.2
Breast cancer (self-reported)	0.7	0.8	2.9	-0.5	0.5	0.5	-1.7	-0.7
Asthma (self-reported)	1.4	2.7	5.0	-1.7	2.2	2.1	-0.0	1.0
Osteoporosis (self-reported)	0.7	0.9	1.2	0.9	-1.1	-0.9	-0.9	-0.8
Osteoarthritis (self-reported)	1.3	1.7	5.6	1.0	-0.2	0.9	2.4	1.1
Medication: Aspirin	9.3	12.1	35.4	-1.6	-0.3	-1.6	-6.0	-4.5
Medication: Gliclazide	0.4	0.4	0.8	0.5	-0.8	-0.2	-0.7	-0.9
Illnesses of father: None of the above (group 1)	2.6	3.3	8.0	2.8	-2.0	-1.1	1.7	-0.0
Smoking status: Current	4.1	6.4	10.1	3.2	-3.1	-2.2	2.7	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.6	3.3	5.7	-2.4	2.2	1.4	-2.1	-0.1
Whole body water mass	3.0	17.2	32.3	-1.4	2.9	4.8	4.5	5.7
Leg predicted mass (right)	2.5	13.2	25.4	-1.1	2.3	4.5	3.7	5.0
Arm fat mass (left)	0.5	1.9	4.7	0.2	-0.3	2.2	0.6	2.1
Number of self-reported non-cancer illnesses	1.6	2.7	9.4	-1.4	0.6	0.5	-3.1	-1.2
Average weekly champagne plus white wine intake	1.2	1.6	2.9	-1.2	1.4	1.7	0.7	1.2
Miserableness	0.5	0.8	1.6	0.7	-1.0	-1.3	0.1	-0.9
Guilty feelings	1.0	1.5	2.7	-1.2	1.3	1.6	0.1	1.2
Wears glasses or contact lenses	0.4	0.4	1.0	-0.7	0.5	0.5	0.5	1.0
Ever taken oral contraceptive pill	0.8	0.9	2.1	-1.1	1.4	1.1	0.3	0.5
Hearing aid user	1.1	1.3	2.3	1.5	-0.9	-0.9	1.5	0.3
Mother’s age at death	1.1	1.4	2.6	0.2	0.4	1.5	1.4	1.6
Financial situation satisfaction	0.2	0.2	0.4	0.5	-0.4	-0.2	-0.6	-0.6
Tinnitus: Yes, now most or all of the time	1.8	2.1	5.6	-1.7	1.0	0.5	-2.4	-0.9
Commuting to job workplace: Public transport	1.6	2.0	3.0	-1.5	1.7	1.5	0.5	1.4
Eye problems/disorders: Glaucoma	0.2	0.2	0.4	-0.2	0.5	0.5	0.7	0.1
Medication: Blood pressure	0.1	0.2	0.4	0.0	-0.6	-0.6	-0.3	0.2
Pain type(s) experienced in last month: Hip pain	1.1	1.4	3.1	1.7	-1.8	-0.5	0.8	0.5
Supplements: Fish oil (including cod liver oil)	1.1	1.5	3.2	-0.6	1.1	0.9	1.8	1.3
High cholesterol (Self-reported)	56.3	99.8	327.6	-5.8	0.9	-2.7	-18.1	-11.4
Medication: Bendroflumethiazide	0.6	0.9	2.3	0.1	-0.3	-0.0	1.5	1.5
Medication: Paracetamol	0.4	0.6	0.9	0.7	-0.8	-0.1	-1.0	-0.9
Medication: Lisinopril	1.6	2.0	2.9	-1.7	1.5	1.6	-1.6	0.3
Medication: Atorvastatin	32.3	39.9	125.4	-2.5	-0.9	-2.6	-11.2	-7.8
Illnesses of father: High blood pressure	1.4	1.8	3.6	-1.9	1.6	1.4	-0.8	0.3
Alcohol drinker status: Never	0.3	0.3	1.0	0.6	0.0	-0.2	1.0	0.6
Ever smoked	1.9	3.4	7.0	-0.5	1.3	2.6	1.2	2.6
Basal metabolic rate	2.4	13.0	25.7	-0.9	2.1	4.3	4.0	5.1
Leg fat percentage (left)	0.7	2.4	6.5	2.1	-2.5	-0.6	-0.7	-0.4
Arm fat-free mass (left)	2.5	12.6	25.1	-0.9	2.2	4.0	4.0	5.0
Number of operations (self-reported)	0.4	0.6	1.0	0.6	-0.9	-0.6	-0.9	-1.0
Average weekly beer plus cider intake	1.8	2.6	4.4	1.9	-1.8	-2.1	-0.0	-1.4
Irritability	1.1	1.9	3.5	-1.4	1.9	1.8	0.0	0.8
Risk taking	1.3	2.0	6.0	0.7	-0.2	0.5	2.4	1.8
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.1	0.1	-0.3	-0.3	0.3	0.3
Fractured/broken bones in last 5 years	0.9	1.2	2.3	0.8	-1.1	-1.5	-0.2	-1.4
Age started oral contraceptive pill	0.6	0.8	1.5	1.2	-0.5	-0.0	1.2	0.8
Diastolic blood pressure, automated reading	0.3	0.8	2.0	-0.1	0.3	0.3	1.4	1.4
Ever depressed for a whole week	0.9	1.1	2.2	-1.2	0.6	0.5	-1.5	-1.1
Unable to work because of sickness or disability	0.7	0.9	2.5	-1.1	0.3	0.7	-1.6	-0.1
Commuting to job workplace: Cycle	0.4	0.5	1.3	0.2	0.4	1.1	0.5	1.0
Myopia	2.7	3.9	6.0	-2.1	2.1	2.4	0.9	2.0
Vascular/heart problems diagnosed by doctor	0.6	1.6	2.9	1.7	-1.3	-1.3	0.8	-1.1
Cholesterol lowering medication	26.9	39.7	130.0	-2.4	-0.8	-2.5	-11.4	-7.5
Medication: Omeprazole (e.g. Zanprol)	0.4	0.4	1.0	0.4	-0.7	-0.1	-1.0	-0.8
Pain experienced in last month	2.0	3.3	5.6	-2.4	2.3	2.0	0.1	1.3
Supplements: Calcium	0.5	0.6	1.0	-1.0	0.1	-0.7	-1.0	-0.8
Basal cell carcinoma (self-reported)	0.1	0.2	0.3	-0.4	0.3	0.5	-0.1	0.6
Heart attack/myocardial infarction (self-reported)	7.3	9.4	28.8	-2.1	0.2	-0.7	-5.4	-3.6
Deep venous thrombosis (DVT) (self-reported)	0.3	0.3	1.0	1.0	-0.5	-0.3	0.5	0.2
Heart disease (siblings)	4.1	5.1	12.8	1.1	-1.8	-1.4	-3.6	-2.4
Alcohol drinker status: Previous	3.0	3.5	6.5	-2.3	1.8	1.0	-2.5	-1.1
Pack years of smoking	2.9	4.3	6.6	2.3	-2.6	-2.5	-0.0	-1.8
Impedance of whole body	7.1	35.9	61.5	5.0	-6.3	-7.8	-3.0	-6.6
Leg fat mass (left)	0.3	1.2	1.6	1.1	-1.2	1.1	0.5	1.3
Arm predicted mass (left)	2.6	13.1	26.0	-0.7	2.1	4.1	4.2	5.1