Hub : Genes

SORT1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Esophagus Mucosa 0.2000 0.0650 2.0e-04 0.068 NA 0.037 NA 0.044 2.6e-05 NA 1.7e-03 NA 6.7e-04
2 GTEx Testis 0.2490 0.0680 4.2e-06 0.169 NA 0.122 NA 0.170 5.6e-08 NA 4.7e-06 NA 5.2e-08
3 NTR Blood 0.0494 0.0125 5.3e-14 0.057 0.045 0.048 0.049 0.056 1.0e-17 1.9e-14 3.1e-15 1.9e-15 2.1e-17
4 TCGA Liver Hepatocellular Carcinoma 0.2310 0.0750 4.5e-06 0.160 0.149 0.141 NA 0.162 5.5e-08 1.7e-07 3.6e-07 NA 4.6e-08
5 TCGA Stomach Adenocarcinoma 0.0410 0.0260 7.0e-03 0.011 0.027 -0.001 NA 0.006 5.1e-02 4.4e-03 3.5e-01 NA 1.1e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 2.4 3.8 5.7 -1.6 2.3 2.4 0.9 2.1
Bipolar Disorder or Schizophrenia 0.4 0.9 1.8 -0.4 1.1 1.4 0.8 0.9
Depressed Affect (Nagel 2018) 0.5 1.1 3.0 1.0 -0.5 0.3 1.7 1.1
Depression (Nagel 2018) 0.4 0.6 1.3 0.6 -0.4 1.1 0.4 1.1
Intelligence (Savage-Jansen 2018) 6.7 20.6 41.9 -4.5 4.9 6.5 0.1 4.1
Neuroticism (Nagel 2018) 1.0 2.3 4.1 -1.0 1.5 2.0 1.1 1.8
Schizophrenia (2018) 0.1 0.3 0.6 0.8 -0.5 -0.2 0.4 -0.5
Schizophrenia vs Biploar Disorder 1.3 1.7 2.8 1.2 -1.5 -1.5 -0.1 -1.7
Worry (Nagel 2018) 0.7 1.4 2.5 -1.2 1.6 1.6 -0.1 0.8
Alzheimer’s Disease (in mother) 0.3 0.3 0.6 -0.7 0.5 0.1 -0.8 -0.4
Alzheimer’s Disease (in father) 0.8 0.8 2.0 0.6 -0.9 -1.4 1.0 0.1
Alzheimer’s Disease (including proxy) 0.1 0.1 0.4 0.1 -0.3 -0.6 0.3 0.1
Crohns Disease (2017) 1.1 2.4 6.9 -2.6 1.9 0.8 -0.7 0.5
Irritable Bowel Disease (IBD) 0.7 1.7 4.3 -2.1 1.9 0.6 -0.6 0.1
Ulcerative Colitis (UC) 0.5 1.0 2.4 -1.4 1.5 0.5 -0.6 -0.1
Major Depression (MDD) 1.4 1.7 3.0 -0.9 1.0 1.7 1.0 1.6
Reaction Time 0.6 1.2 1.8 1.3 -1.3 -1.0 1.2 0.2
Verbal and Numeric Reasoning (VNR) 5.8 13.9 30.7 -3.4 3.9 5.5 -0.2 3.5
Breast Cancer 1.4 3.4 7.6 2.8 -1.9 -1.9 0.7 -1.2
Ovarian Cancer 0.1 0.2 0.4 0.1 0.2 -0.6 0.6 -0.1
Prostate Cancer 0.2 0.3 0.6 0.7 -0.8 0.3 -0.3 -0.0
Age at First Birth 1.4 2.1 3.9 -1.1 2.0 1.3 1.1 1.6
Bipolar Disorder (2011) 0.3 0.3 1.4 0.0 0.0 0.0 0.0 1.2
Body Mass Index (BMI) (2010) 1.6 2.2 4.8 1.2 -1.5 0.0 2.2 1.5
Coronary Artery Disease (CAD) 5.6 6.7 27.9 -1.4 -0.6 -1.8 0.0 -5.3
Crohns Disease (2012) 1.3 2.1 5.0 -2.2 1.5 0.4 -1.6 -0.8
Mean Putamen Volume 0.6 0.7 1.8 -0.6 -0.2 -0.9 -0.9 -1.3
Fasting Glucose 2.3 2.8 5.5 -0.2 0.8 1.6 2.3 2.3
HbA1C 0.1 0.1 0.4 -0.3 0.3 0.2 -0.1 0.6
HDL Cholesterol 5.9 9.8 29.7 -0.6 1.7 1.2 5.5 3.8
LDL Cholesterol 159.4 252.2 739.8 -5.8 -2.8 -8.2 -27.2 -20.3
Lupus 0.8 1.2 2.4 -1.1 1.3 1.5 -0.1 0.9
Neuroticism (2016) 0.1 0.2 0.5 -0.5 0.4 0.2 -0.7 -0.2
Primary Biliary Cirrhosis 0.3 0.5 1.2 1.1 -1.0 -0.5 0.1 -0.1
Rheumatoid Arthritis 1.0 1.4 2.4 -1.6 1.1 -0.3 -1.1 -1.4
Schizophrenia (2014) 0.1 0.2 0.4 0.6 -0.5 -0.1 0.2 -0.4
Triglycerides 0.9 1.5 3.1 0.1 -1.4 -0.7 -1.8 -1.4
Type 2 Diabetes (T2D) (2012) 3.3 3.8 6.3 2.3 -1.7 0.3 2.5 2.0
Ulcerative Colitis 0.4 0.6 1.5 0.2 -0.2 -0.7 -0.9 -1.2
Blood Eosinophil Count 0.4 3.0 5.3 -2.3 1.7 2.0 -1.7 0.6
Blood Platelet Count 0.4 4.7 9.1 2.5 -3.0 -2.6 0.5 -1.1
Blood Red Count 1.4 13.5 21.6 -4.3 4.7 4.2 0.6 3.1
Blood White Count 0.5 3.6 6.9 2.1 -1.3 0.5 2.6 2.2
Heel T-Score 1.8 13.9 27.4 -1.0 2.5 4.0 4.4 5.2
BMI 2.2 12.5 31.8 -2.4 2.5 5.6 0.5 4.4
Height 0.9 16.5 55.2 3.6 -1.4 -1.0 7.4 3.3
Waist Hip Ratio (WHR) 0.7 2.9 7.0 -0.6 1.1 0.7 2.6 2.3
Systolic Blood Pressure 0.5 2.6 6.9 -2.6 1.7 0.7 -1.6 0.1
Smoking Status 1.7 4.1 11.0 1.4 -0.8 1.0 3.3 2.4
Allergy or Eczema 0.9 2.5 4.0 -1.8 2.0 1.1 1.1 1.6
Cardiovascular Disease 9.9 32.8 108.2 -4.4 1.7 -0.3 -10.4 -5.8
Hypothyroidism (self reported) 0.6 1.3 3.2 -1.8 1.3 1.1 -0.5 0.2
Respiratory disease 2.5 5.5 9.8 -1.4 2.3 3.1 1.7 2.8
Type 2 Diabetes (T2D) (2018) 0.3 0.7 1.3 0.6 -0.3 0.6 1.1 1.1
Lung FEV1/FVC ratio 1.3 6.5 23.9 -1.4 -0.5 0.1 -4.9 -2.5
Lung FVC 0.1 0.5 1.8 0.5 0.3 -0.3 1.3 0.2
Neuroticism 1.5 3.5 7.1 -1.1 1.7 2.7 1.2 2.2
Chronotype (morning person) 1.4 3.2 7.1 -2.7 2.4 0.7 -1.4 -0.5
Hair Pigment 0.1 2.8 6.4 2.1 -2.5 -1.6 0.1 -0.7
Tanning 0.4 4.4 6.2 -1.6 2.5 1.2 2.5 2.4
Hand grip strength (left) 0.5 1.2 4.5 0.3 0.5 0.4 2.1 1.1
Number of treatments/medications taken 5.2 9.4 28.9 -2.4 0.6 -0.2 -5.4 -3.4
Average weekly spirits intake 0.1 0.1 0.2 0.2 -0.3 0.0 0.3 0.5
Sensitivity / hurt feelings 2.4 4.1 8.8 -1.6 2.0 3.0 0.9 2.1
Frequency of depressed mood in last 2 weeks 0.4 0.5 1.3 0.3 0.1 1.0 0.6 1.1
Hearing difficulty/problems: Yes 2.2 3.3 9.4 2.0 -1.0 -0.1 3.1 1.5
Relative age of first facial hair 0.3 0.6 1.6 0.8 -0.4 -1.3 0.0 -0.9
Other serious medical condition/disability diagnosed by doctor 2.5 3.2 10.3 -0.9 0.1 -0.2 -3.2 -2.2
Ever used hormone-replacement therapy (HRT) 1.0 1.3 3.2 1.0 -0.9 -1.1 1.8 0.4
Ever had hysterectomy (womb removed) 0.5 0.6 0.9 0.9 -0.6 -0.8 0.1 -1.0
Systolic blood pressure, automated reading 0.6 1.8 3.1 -1.2 1.1 1.6 0.4 1.8
Eye problems/disorders: Diabetes related eye disease 0.1 0.1 0.3 0.1 0.2 0.5 0.0 0.6
Angina 10.6 14.0 48.5 -1.8 0.2 -0.5 -7.0 -4.2
Medication for hormone replacement therapy 0.0 0.0 0.1 -0.1 0.1 -0.2 -0.0 -0.3
Vitamin and mineral supplements 0.6 0.8 1.6 0.5 -0.9 -1.3 -0.5 -1.1
Supplements: Zinc 1.0 1.1 1.8 -1.0 1.0 1.3 0.9 1.1
Medication: Co-codamol 0.7 0.8 1.6 0.4 -0.7 -0.9 -0.9 -1.3
Medication: Metformin 1.0 1.4 3.2 1.4 -1.8 -0.8 1.0 0.2
Diabetes (father) 2.4 3.0 8.7 1.7 -0.9 -1.4 2.9 0.8
Diabetes (mother) 1.8 2.4 4.7 2.2 -1.2 -0.2 2.2 0.9
Severe depression (siblings) 0.2 0.2 0.4 -0.4 0.3 0.1 -0.7 -0.6
Pack years adult smoking proportion 3.3 5.0 7.9 2.3 -2.7 -2.8 -0.3 -2.2
Impedance of leg (right) 7.7 37.3 69.4 4.8 -6.0 -8.3 -2.9 -7.0
Leg fat-free mass (left) 2.2 11.8 21.4 -1.3 2.3 4.5 3.2 4.6
Trunk fat percentage 0.7 2.8 7.6 2.1 -2.8 -0.9 -0.9 -0.7
Hand grip strength (right) 0.4 1.1 4.5 0.6 0.1 -0.2 2.1 0.8
Townsend deprivation index at recruitment 1.2 1.7 4.5 -0.9 1.4 2.1 -1.1 0.4
Current tobacco smoking 2.8 4.5 7.0 2.6 -2.5 -1.8 2.5 0.4
Average weekly fortified wine intake 1.2 1.4 2.2 -0.7 1.1 1.4 1.0 1.5
Maternal smoking around birth 0.8 1.2 3.0 0.2 -0.7 -0.8 -1.7 -1.4
Fed-up feelings 1.2 2.1 5.1 1.3 -0.6 0.6 2.3 1.8
Frequency of unenthusiasm / disinterest in last 2 weeks 0.3 0.3 0.7 -0.1 -0.2 0.9 -0.9 0.4
Relative age voice broke 1.5 2.3 3.8 -1.6 1.7 1.9 -0.1 1.5
Taking other prescription medications 0.7 1.1 2.2 -1.1 0.5 1.5 -1.3 -0.0
Age when periods started (menarche) 0.8 1.9 2.6 1.6 -1.6 -1.3 -0.7 -1.4
Bilateral oophorectomy (both ovaries removed) 0.2 0.2 0.5 0.0 -0.3 -0.6 -0.2 -0.7
Heel bone mineral density (BMD) T-score, automated (left) 0.5 1.2 2.6 -0.4 0.7 1.1 1.2 1.6
Tinnitus: Yes, but not now, but have in the past 0.6 0.6 2.0 1.4 -1.0 -0.4 0.2 0.1
Qualifications: CSEs or equivalent 2.1 2.7 6.4 -0.2 -0.7 -1.5 -2.5 -2.2
Serious illness, injury or assault to yourself 3.5 4.2 6.3 0.8 -1.9 -2.0 -2.5 -2.5
High blood pressure 0.8 2.2 5.0 -1.1 1.3 1.7 0.7 2.2
Hayfever, allergic rhinitis or eczema 0.7 1.6 3.6 -1.9 1.8 0.8 0.3 0.7
Multivitamins +/- minerals 2.7 3.4 6.3 -2.5 2.5 1.9 0.1 0.9
Stomach or abdominal pain in last month 3.3 4.1 5.7 2.4 -2.1 -2.4 -0.4 -2.1
Supplements: Glucosamine 2.6 3.3 5.9 -0.9 1.1 2.2 2.4 2.0
Diverticular disease/diverticulitis (self-reported) 1.0 1.1 2.2 -1.3 1.5 1.3 -0.2 0.2
Medication: Atenolol 2.5 3.1 9.0 -1.8 0.2 -0.4 -3.0 -1.8
Medication: Levothyroxine sodium 0.1 0.2 0.5 -0.7 0.3 0.1 -0.5 -0.1
Sitting height 0.1 0.9 2.7 0.9 -0.4 -0.2 1.6 0.9
Chronic bronchitis/emphysema (father) 0.3 0.4 1.1 -0.8 1.0 0.4 -0.3 -0.1
High blood pressure (mother) 1.8 2.5 4.5 -1.7 1.3 1.8 -2.1 -0.0
Body mass index (BMI) 1.2 5.1 13.5 -1.4 1.3 3.7 0.2 2.9
Impedance of leg (left) 8.1 39.3 73.8 5.3 -6.5 -8.6 -2.6 -6.8
Leg predicted mass (left) 2.3 12.0 21.9 -1.2 2.3 4.5 3.3 4.7
Trunk fat mass 0.3 1.2 2.4 1.4 -1.6 0.6 0.4 1.0
Waist circumference 1.1 4.1 9.8 -0.2 0.7 2.8 1.6 3.1
Number of incorrect matches in round 0.1 0.2 0.7 0.9 -0.3 -0.2 0.5 0.3
Past tobacco smoking 0.6 1.0 2.4 0.3 -0.7 -1.6 -0.3 -1.4
Alcohol usually taken with meals 0.2 0.3 0.6 -0.7 0.4 0.3 -0.8 -0.3
Nervous feelings 0.7 1.3 2.0 -1.2 1.3 1.4 0.2 1.0
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.5 1.9 -0.1 -0.4 -0.3 -1.4 -0.6
Hearing difficulty/problems with background noise 1.9 3.0 7.6 2.8 -2.1 -0.0 1.6 0.7
Hair/balding pattern: Pattern 2 0.4 0.6 1.2 -0.7 1.1 1.0 0.3 0.4
Had menopause 1.4 1.7 5.8 1.4 -0.5 -0.3 2.4 0.9
Had other major operations 0.1 0.2 0.4 0.7 -0.3 0.4 0.0 0.3
Forced vital capacity (FVC) 0.1 0.3 0.6 -0.1 0.1 -0.8 0.3 -0.7
Heel bone mineral density (BMD) T-score, automated (right) 0.6 1.4 3.2 0.1 0.4 1.0 1.7 1.8
Ever unenthusiastic/disinterested for a whole week 1.5 1.8 4.5 0.2 -0.7 -0.7 -2.1 -1.9
Qualifications: None of the above 5.4 11.7 18.9 4.2 -4.3 -4.3 0.6 -1.7
Financial difficulties in last 2 years 1.2 1.6 2.3 -1.5 1.2 1.5 -1.4 -0.1
Mouth/teeth dental problems 0.2 0.4 0.7 -0.4 0.8 0.3 0.8 0.4
Heart attack 7.2 9.3 28.7 -2.2 0.4 -0.6 -5.4 -3.5
Allergy 0.5 1.2 2.0 1.4 -1.4 -0.9 -0.6 -1.1
Pain all over the body in last month 0.5 0.5 1.5 -0.2 0.3 0.9 -1.2 -0.1
Diabetes (self-reported) 0.3 0.4 1.1 0.7 -1.0 -0.1 0.4 0.5
Hayfever/allergic rhinitis (self-reported) 0.4 0.5 1.3 -0.9 1.1 0.4 0.6 0.2
Medication: Ramipril 2.5 3.2 6.0 -2.5 1.4 -0.9 -2.2 -1.6
Medication: Simvastatin 28.9 42.4 139.2 -4.1 0.8 -1.8 -11.8 -7.2
Fluid intelligence score 5.5 11.4 24.5 -3.2 3.6 5.0 -0.0 3.0
Illnesses of siblings 0.8 1.2 3.6 -0.5 0.8 0.4 1.9 1.1
Neuroticism score 1.3 2.6 4.5 -0.8 1.4 2.1 1.3 2.1
Weight 1.1 5.3 12.3 0.2 0.4 2.8 2.4 3.5
Impedance of arm (right) 6.6 31.0 48.0 4.9 -6.2 -6.9 -2.7 -6.1
Arm fat percentage (right) 0.3 1.0 2.5 1.0 -1.6 0.8 -1.0 0.3
Trunk fat-free mass 3.2 18.1 34.0 -1.3 2.9 4.5 5.1 5.8
Hip circumference 0.2 1.0 1.5 1.1 -1.1 1.2 0.2 1.2
Time employed in main current job 0.6 0.6 1.1 0.5 -0.6 -1.1 -0.8 -0.9
Alcohol intake versus 10 years previously 2.5 3.7 4.9 -1.7 2.1 2.2 1.4 2.0
Father’s age at death 8.7 11.7 22.3 -0.8 2.2 3.1 4.7 4.6
Worrier / anxious feelings 0.6 1.2 3.1 0.3 0.1 0.8 1.8 1.4
Frequency of tiredness / lethargy in last 2 weeks 0.7 1.1 2.2 -1.5 1.1 1.0 -1.1 0.2
Falls in the last year 2.9 4.0 7.0 2.6 -2.7 -2.2 -0.0 -1.2
Hair/balding pattern: Pattern 3 1.2 1.8 3.8 -1.9 1.9 0.9 0.6 0.3
Number of live births 3.1 4.3 7.9 2.8 -2.7 -2.4 1.0 -0.4
Forced expiratory volume in 1-second (FEV1) 0.3 0.8 2.2 -0.3 -0.1 -0.9 -1.1 -1.5
Pulse rate 1.3 2.3 4.6 -1.8 1.1 -0.6 -2.1 -1.4
Happiness 0.2 0.2 0.4 -0.4 0.7 0.5 0.0 0.6
Noisy workplace 3.7 4.6 7.8 2.5 -2.5 -2.8 1.4 -0.7
Qualifications: A levels/AS levels or equivalent 1.8 4.1 7.5 -2.7 2.7 2.2 -0.6 0.6
Serious illness, injury or assault of a close relative in last 2 years 2.1 2.4 4.7 -2.2 2.0 1.1 -1.4 -0.1
Mouth/teeth dental problems: Dentures 0.3 0.4 0.9 -0.5 0.4 0.5 0.7 1.0
Asthma 1.4 2.8 5.2 -1.8 2.3 2.2 -0.1 1.0
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.3 0.6 0.6 -0.8 -0.2 0.2 -0.7
Medication: Cholesterol lowering 44.7 69.5 219.0 -5.5 1.1 -2.5 -14.8 -9.5
Depression (self-reported) 0.7 0.8 2.2 1.5 -1.3 -0.3 0.4 0.4
Medication: Lansoprazole 1.5 1.7 2.6 1.6 -1.5 -1.6 0.3 -1.0
Prospective memory result 1.0 1.2 4.8 0.4 0.3 0.3 2.2 1.0
Lung cancer (father) 2.4 2.8 4.4 2.1 -1.9 -1.6 1.8 0.0
Illnesses of mother 2.9 3.6 6.7 2.5 -2.6 -1.8 1.4 -0.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.0 0.0 0.1 -0.1 0.3 0.3 -0.1 -0.1
Pulse wave Arterial Stiffness index 0.7 0.8 2.2 1.1 -1.5 -0.8 0.1 -0.0
Impedance of arm (left) 5.0 22.9 36.7 3.9 -5.1 -6.1 -2.7 -5.4
Arm fat mass (right) 0.5 2.2 5.1 0.3 -0.3 2.3 0.7 2.2
Trunk predicted mass 3.2 18.4 34.5 -1.3 3.0 4.6 5.0 5.9
Standing height 0.9 9.1 27.2 3.2 -1.7 -1.3 5.2 2.0
Length of working week for main job 2.5 2.8 4.3 -2.0 1.9 2.1 -1.1 0.9
Exposure to tobacco smoke at home 1.0 1.2 2.1 1.4 -1.4 -0.6 -0.7 -0.8
Breastfed as a baby 1.3 1.7 3.5 -0.6 1.0 1.0 1.9 1.5
Tense / ‘highly strung’ 1.2 2.0 2.9 -1.7 1.5 1.6 -1.5 -0.1
Seen doctor (GP) for nerves, anxiety, tension or depression 0.4 0.5 1.1 -0.7 0.7 0.8 -1.0 -0.4
Hair/balding pattern: Pattern 4 0.2 0.4 0.6 0.7 -0.8 -0.6 -0.6 -0.4
Birth weight of first child 4.2 7.6 12.0 -3.2 3.5 2.8 1.2 2.6
Peak expiratory flow (PEF) 1.2 2.8 6.1 0.8 -1.4 -1.9 -1.5 -2.5
Pulse wave reflection index 0.7 0.8 1.5 1.2 -1.0 -0.3 0.9 0.8
Ever highly irritable/argumentative for 2 days 0.6 0.7 1.5 -0.3 0.6 1.2 0.4 1.2
Loud music exposure frequency 0.1 0.2 0.6 0.8 -0.4 -0.1 0.1 -0.0
Qualifications: O levels/GCSEs or equivalent 1.8 2.9 5.0 -2.2 2.1 2.0 -1.1 -0.0
Mouth/teeth dental problems: Bleeding gums 1.0 1.3 1.8 0.8 -1.2 -0.9 -1.4 -1.2
Blood clot in the leg (DVT) 0.2 0.3 0.7 0.9 -0.4 -0.0 0.5 0.4
Medication: Paracetamol 0.8 1.4 2.9 1.5 -1.7 -0.7 -0.6 -1.0
Headache pain in last month 0.8 1.4 3.1 0.6 -0.5 -1.2 -1.4 -1.8
Medication for cholesterol, blood pressure or diabetes 14.6 24.2 73.3 4.4 -1.8 0.6 8.6 5.0
Glaucoma (self-reported) 0.5 0.6 1.2 -0.6 0.8 0.6 1.1 0.7
Gout (self-reported) 1.3 1.7 4.8 0.5 0.5 0.6 2.2 1.7
Hypothyroidism/myxoedema (self-reported) 0.1 0.2 0.7 -0.8 0.6 0.4 0.1 0.0
Medication: Amlodipine 0.8 1.1 2.6 -1.0 0.0 -0.5 -1.6 -1.3
Medication: Ventolin 100micrograms inhaler 2.9 3.8 5.6 -1.1 2.0 2.4 1.7 2.2
Birth weight 1.9 4.1 6.7 -2.6 2.6 2.3 -1.3 0.6
Chronic bronchitis/emphysema (mother) 0.9 1.1 2.1 -0.6 0.4 -1.2 -1.1 -1.4
High blood pressure (siblings) 1.2 1.8 6.4 -1.0 0.3 0.4 -2.5 -1.1
Forced vital capacity (FVC), Best measure 0.1 0.4 1.3 0.1 0.4 0.3 1.2 0.7
Body fat percentage 0.7 2.7 7.2 1.9 -2.7 -0.7 -1.1 -0.7
Leg fat percentage (right) 0.7 2.4 6.3 1.8 -2.5 -0.8 -1.1 -0.9
Arm fat-free mass (right) 2.9 15.1 29.4 -1.1 2.6 4.4 4.4 5.4
Exposure to tobacco smoke outside home 2.0 2.7 5.4 2.3 -2.3 -1.4 0.9 0.4
Comparative body size at age 10 2.4 6.5 15.4 -1.8 1.9 3.9 0.3 3.2
Number of full brothers 5.4 6.8 14.0 3.7 -3.4 -2.3 -0.1 -1.8
Worry too long after embarrassment 0.6 1.0 2.3 0.4 -0.1 0.9 1.4 1.5
Seen a psychiatrist for nerves, anxiety, tension or depression 0.1 0.1 0.2 -0.3 0.5 0.5 -0.1 0.1
Wheeze or whistling in the chest in last year 0.7 1.2 1.8 -0.2 1.2 1.3 1.3 1.0
Number of children fathered 1.0 1.1 2.5 0.7 -1.0 -1.6 -0.3 -1.2
Reason for reducing amount of alcohol drunk: Health precaution 2.7 3.1 6.2 -2.4 2.5 1.6 -0.8 0.6
Age at first live birth 1.1 2.0 4.7 -2.2 1.9 0.5 0.6 1.0
Pulse wave peak to peak time 0.7 0.8 2.2 -0.9 1.5 0.9 0.2 0.3
Health satisfaction 0.8 1.0 3.3 -0.4 -0.2 -0.1 -1.8 -1.2
Shortness of breath walking on level ground 0.6 0.7 1.0 1.0 -0.8 -0.5 -0.8 -0.9
Qualifications: College or University degree 4.9 15.5 25.7 -3.8 4.5 5.1 1.5 3.9
Eye problems/disorders: None of the above 0.5 0.6 1.0 -0.8 0.9 1.0 0.0 0.7
Mouth/teeth dental problems: Loose teeth 0.9 1.1 2.0 -1.4 1.2 1.0 -0.9 0.1
Emphysema/chronic bronchitis 0.1 0.1 0.1 -0.2 0.1 -0.3 0.2 0.3
Medication for pain relief, constipation, heartburn 3.3 5.6 12.8 -0.3 1.3 1.1 3.6 3.5
Neck or shoulder pain in last month 7.0 10.0 15.8 2.3 -3.1 -3.6 -2.5 -4.0
Medication: Blood pressure 2.7 4.7 10.8 -3.3 2.5 1.5 -2.0 -0.1
Angina (self-reported) 11.6 15.3 53.0 -1.9 -0.0 -0.8 -7.3 -4.4
Migraine (self-reported) 1.0 1.3 3.7 -0.4 -0.1 -0.5 -1.9 -1.5
Medication: Ibuprofen 0.1 0.1 0.4 0.4 -0.3 -0.0 0.1 -0.7
Medication: Allopurinol 1.7 2.2 3.3 -0.7 1.5 1.6 1.6 1.8
Medication: Omeprazole 0.5 0.6 1.3 0.5 -1.0 -0.1 -1.1 -0.7
Medication: Seretide 50 evohaler 1.1 1.3 3.8 0.2 -0.1 0.1 1.9 1.6
Mean time to correctly identify matches 1.4 2.6 5.5 1.9 -1.6 -1.0 2.3 0.9
Heart disease (mother) 1.0 1.2 3.3 -0.8 0.6 -0.4 -1.8 -1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.7 1.1 0.1 -0.0 -1.1 -1.0 -1.0
Whole body fat mass 0.3 1.3 2.6 1.4 -1.6 0.7 0.5 1.0
Leg fat mass (right) 0.2 0.9 1.4 1.0 -1.2 1.0 0.3 1.0
Arm predicted mass (right) 3.0 15.4 29.7 -1.3 2.8 4.4 4.3 5.5
Pulse rate, automated reading 2.1 6.7 15.3 -1.0 -0.3 -2.1 -3.9 -3.6
Alcohol intake frequency. 0.8 1.8 3.3 -1.5 1.8 1.5 -0.7 0.7
Comparative height size at age 10 1.1 6.3 19.8 2.3 -1.3 -0.9 4.5 2.0
Number of full sisters 1.0 1.2 2.7 1.0 -1.3 -1.7 -0.4 -0.7
Suffer from ‘nerves’ 0.2 0.4 0.9 0.3 -0.6 -0.9 -0.4 -0.6
Overall health rating 0.2 0.5 1.9 -0.2 -0.2 0.4 -1.4 -0.4
Chest pain or discomfort 3.1 4.4 8.4 0.7 -1.5 -1.7 -2.9 -2.8
Had major operations 0.9 1.0 3.0 -0.6 -0.2 -0.5 -1.7 -1.2
Age at last live birth 1.6 2.3 6.0 -2.4 2.0 0.9 -0.5 0.8
Family relationship satisfaction 0.5 0.6 1.1 -0.6 1.1 1.0 -0.8 -0.0
Leg pain on walking 2.4 3.0 6.2 2.4 -2.5 -1.6 0.9 -0.4
Qualifications: NVQ or HND or HNC or equivalent 1.9 2.2 4.2 1.0 -1.3 -1.9 -0.8 -2.0
Commuting to job workplace: Car/motor vehicle 1.6 1.8 3.0 1.1 -1.7 -1.7 -0.5 -1.3
Illness, injury, bereavement, stress in last 2 years 0.8 1.0 1.5 1.1 -1.1 -0.9 1.2 0.4
Medication: Aspirin 9.0 11.9 34.2 -1.4 -0.3 -1.6 -5.8 -4.5
Supplements: Vitamin C 1.8 2.1 5.1 1.3 -0.4 0.6 2.3 1.8
Knee pain experienced in last month 0.7 1.1 2.8 1.3 -1.7 -0.8 0.7 -0.1
Hypertension (Self-reported) 0.6 1.7 3.2 -1.2 1.3 1.4 0.0 1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.4 0.5 1.7 0.2 -0.6 -1.3 0.0 -0.6
Illnesses of father: Heart disease 10.4 14.4 36.8 -4.6 2.4 0.9 -6.1 -2.7
Illnesses of siblings: Diabetes 2.5 3.1 6.4 2.5 -2.0 -1.8 1.4 0.0
Smoking status: Previous 1.7 2.5 5.4 -1.4 1.8 2.3 -0.3 1.3
Forced expiratory volume in 1-second (FEV1), predicted 0.6 1.2 4.5 0.7 0.2 0.2 2.1 0.9
Whole body fat-free mass 3.0 17.2 32.5 -1.3 2.8 4.8 4.6 5.7
Leg fat-free mass (right) 2.6 13.9 26.4 -1.3 2.5 4.7 3.7 5.1
Arm fat percentage (left) 0.2 0.9 1.5 0.6 -1.1 1.2 -0.8 0.7
Average weekly red wine intake 1.4 2.0 4.1 0.1 -1.2 -1.0 -1.9 -2.0
Handedness (chirality/laterality): Left-handed 0.7 0.8 2.0 -0.7 1.2 1.4 0.2 0.4
Mood swings 1.1 2.1 4.8 -0.3 0.8 1.3 1.7 2.2
Loneliness, isolation 0.2 0.2 0.5 0.6 -0.7 0.3 0.4 0.2
Long-standing illness, disability or infirmity 0.6 0.9 2.5 0.6 -0.8 0.0 -1.6 -1.0
Ever had bowel cancer screening 0.1 0.1 0.3 -0.3 0.2 0.5 -0.4 0.2
Diabetes diagnosed by doctor 0.2 0.3 0.6 0.6 -0.8 0.4 -0.0 0.5
Ever had stillbirth, spontaneous miscarriage or termination 2.4 2.6 5.3 2.3 -2.0 -1.3 1.2 0.4
Friendships satisfaction 0.4 0.5 1.2 -1.1 0.6 0.5 -0.8 -0.2
Qualifications: nursing, teaching 1.1 1.7 3.1 -1.4 1.8 1.7 -0.7 0.2
Commuting to job workplace: Walk 2.9 3.1 4.7 -2.0 2.1 1.6 -2.2 -0.1
Eye problems/disorders: Cataract 0.8 0.9 1.8 1.0 -1.4 -1.2 0.2 -0.4
Mouth/teeth dental problems: Mouth ulcers 0.6 1.0 1.6 0.5 -0.8 -1.2 -0.9 -1.3
Medication for cholesterol 5.9 8.9 27.1 1.5 0.5 1.5 5.2 3.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.4 0.7 -0.9 0.3 0.7 0.3 0.8
Back pain experienced in last month 2.8 4.0 8.1 2.2 -2.9 -2.4 0.2 -1.2
Mineral and other dietary supplements 0.3 0.4 1.2 0.5 -0.4 -0.6 -1.1 -0.2
Breast cancer (self-reported) 0.7 0.8 2.9 -0.5 0.5 0.5 -1.7 -0.7
Asthma (self-reported) 1.4 2.7 5.0 -1.7 2.2 2.1 -0.0 1.0
Osteoporosis (self-reported) 0.7 0.9 1.2 0.9 -1.1 -0.9 -0.9 -0.8
Osteoarthritis (self-reported) 1.3 1.7 5.6 1.0 -0.2 0.9 2.4 1.1
Medication: Aspirin 9.3 12.1 35.4 -1.6 -0.3 -1.6 -6.0 -4.5
Medication: Gliclazide 0.4 0.4 0.8 0.5 -0.8 -0.2 -0.7 -0.9
Illnesses of father: None of the above (group 1) 2.6 3.3 8.0 2.8 -2.0 -1.1 1.7 -0.0
Smoking status: Current 4.1 6.4 10.1 3.2 -3.1 -2.2 2.7 0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.6 3.3 5.7 -2.4 2.2 1.4 -2.1 -0.1
Whole body water mass 3.0 17.2 32.3 -1.4 2.9 4.8 4.5 5.7
Leg predicted mass (right) 2.5 13.2 25.4 -1.1 2.3 4.5 3.7 5.0
Arm fat mass (left) 0.5 1.9 4.7 0.2 -0.3 2.2 0.6 2.1
Number of self-reported non-cancer illnesses 1.6 2.7 9.4 -1.4 0.6 0.5 -3.1 -1.2
Average weekly champagne plus white wine intake 1.2 1.6 2.9 -1.2 1.4 1.7 0.7 1.2
Miserableness 0.5 0.8 1.6 0.7 -1.0 -1.3 0.1 -0.9
Guilty feelings 1.0 1.5 2.7 -1.2 1.3 1.6 0.1 1.2
Wears glasses or contact lenses 0.4 0.4 1.0 -0.7 0.5 0.5 0.5 1.0
Ever taken oral contraceptive pill 0.8 0.9 2.1 -1.1 1.4 1.1 0.3 0.5
Hearing aid user 1.1 1.3 2.3 1.5 -0.9 -0.9 1.5 0.3
Mother’s age at death 1.1 1.4 2.6 0.2 0.4 1.5 1.4 1.6
Financial situation satisfaction 0.2 0.2 0.4 0.5 -0.4 -0.2 -0.6 -0.6
Tinnitus: Yes, now most or all of the time 1.8 2.1 5.6 -1.7 1.0 0.5 -2.4 -0.9
Commuting to job workplace: Public transport 1.6 2.0 3.0 -1.5 1.7 1.5 0.5 1.4
Eye problems/disorders: Glaucoma 0.2 0.2 0.4 -0.2 0.5 0.5 0.7 0.1
Medication: Blood pressure 0.1 0.2 0.4 0.0 -0.6 -0.6 -0.3 0.2
Pain type(s) experienced in last month: Hip pain 1.1 1.4 3.1 1.7 -1.8 -0.5 0.8 0.5
Supplements: Fish oil (including cod liver oil) 1.1 1.5 3.2 -0.6 1.1 0.9 1.8 1.3
High cholesterol (Self-reported) 56.3 99.8 327.6 -5.8 0.9 -2.7 -18.1 -11.4
Medication: Bendroflumethiazide 0.6 0.9 2.3 0.1 -0.3 -0.0 1.5 1.5
Medication: Paracetamol 0.4 0.6 0.9 0.7 -0.8 -0.1 -1.0 -0.9
Medication: Lisinopril 1.6 2.0 2.9 -1.7 1.5 1.6 -1.6 0.3
Medication: Atorvastatin 32.3 39.9 125.4 -2.5 -0.9 -2.6 -11.2 -7.8
Illnesses of father: High blood pressure 1.4 1.8 3.6 -1.9 1.6 1.4 -0.8 0.3
Alcohol drinker status: Never 0.3 0.3 1.0 0.6 0.0 -0.2 1.0 0.6
Ever smoked 1.9 3.4 7.0 -0.5 1.3 2.6 1.2 2.6
Basal metabolic rate 2.4 13.0 25.7 -0.9 2.1 4.3 4.0 5.1
Leg fat percentage (left) 0.7 2.4 6.5 2.1 -2.5 -0.6 -0.7 -0.4
Arm fat-free mass (left) 2.5 12.6 25.1 -0.9 2.2 4.0 4.0 5.0
Number of operations (self-reported) 0.4 0.6 1.0 0.6 -0.9 -0.6 -0.9 -1.0
Average weekly beer plus cider intake 1.8 2.6 4.4 1.9 -1.8 -2.1 -0.0 -1.4
Irritability 1.1 1.9 3.5 -1.4 1.9 1.8 0.0 0.8
Risk taking 1.3 2.0 6.0 0.7 -0.2 0.5 2.4 1.8
Ever had prostate specific antigen (PSA) test 0.1 0.1 0.1 0.1 -0.3 -0.3 0.3 0.3
Fractured/broken bones in last 5 years 0.9 1.2 2.3 0.8 -1.1 -1.5 -0.2 -1.4
Age started oral contraceptive pill 0.6 0.8 1.5 1.2 -0.5 -0.0 1.2 0.8
Diastolic blood pressure, automated reading 0.3 0.8 2.0 -0.1 0.3 0.3 1.4 1.4
Ever depressed for a whole week 0.9 1.1 2.2 -1.2 0.6 0.5 -1.5 -1.1
Unable to work because of sickness or disability 0.7 0.9 2.5 -1.1 0.3 0.7 -1.6 -0.1
Commuting to job workplace: Cycle 0.4 0.5 1.3 0.2 0.4 1.1 0.5 1.0
Myopia 2.7 3.9 6.0 -2.1 2.1 2.4 0.9 2.0
Vascular/heart problems diagnosed by doctor 0.6 1.6 2.9 1.7 -1.3 -1.3 0.8 -1.1
Cholesterol lowering medication 26.9 39.7 130.0 -2.4 -0.8 -2.5 -11.4 -7.5
Medication: Omeprazole (e.g. Zanprol) 0.4 0.4 1.0 0.4 -0.7 -0.1 -1.0 -0.8
Pain experienced in last month 2.0 3.3 5.6 -2.4 2.3 2.0 0.1 1.3
Supplements: Calcium 0.5 0.6 1.0 -1.0 0.1 -0.7 -1.0 -0.8
Basal cell carcinoma (self-reported) 0.1 0.2 0.3 -0.4 0.3 0.5 -0.1 0.6
Heart attack/myocardial infarction (self-reported) 7.3 9.4 28.8 -2.1 0.2 -0.7 -5.4 -3.6
Deep venous thrombosis (DVT) (self-reported) 0.3 0.3 1.0 1.0 -0.5 -0.3 0.5 0.2
Heart disease (siblings) 4.1 5.1 12.8 1.1 -1.8 -1.4 -3.6 -2.4
Alcohol drinker status: Previous 3.0 3.5 6.5 -2.3 1.8 1.0 -2.5 -1.1
Pack years of smoking 2.9 4.3 6.6 2.3 -2.6 -2.5 -0.0 -1.8
Impedance of whole body 7.1 35.9 61.5 5.0 -6.3 -7.8 -3.0 -6.6
Leg fat mass (left) 0.3 1.2 1.6 1.1 -1.2 1.1 0.5 1.3
Arm predicted mass (left) 2.6 13.1 26.0 -0.7 2.1 4.1 4.2 5.1