Best TWAS P=5.43e-09 · Best GWAS P=3.91e-09 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | CELSR2 | 0.03 | 0.00 | lasso | 10 | 0.01 | 1.5e-02 | -5.2 | 5.3 | 1.1e-07 | -0.63 | 0.08 | 0.42 | FALSE |
| 2 | GTEx | Esophagus Mucosa | PSRC1 | 0.18 | 0.14 | lasso | 3 | 0.14 | 2.4e-09 | -5.6 | -5.7 | 1.4e-08 | 0.95 | 0.01 | 0.99 | FALSE |
| 3 | GTEx | Liver | CELSR2 | 0.39 | 0.36 | lasso | 1 | 0.35 | 1.0e-10 | -5.6 | -5.6 | 2.4e-08 | 0.96 | 0.01 | 0.98 | FALSE |
| 4 | GTEx | Muscle Skeletal | CELSR2 | 0.41 | 0.31 | lasso | 4 | 0.30 | 2.4e-30 | -5.6 | -5.5 | 3.3e-08 | 0.95 | 0.02 | 0.98 | FALSE |
| 5 | GTEx | Skin Sun Exposed Lower leg | CELSR2 | 0.18 | 0.05 | lasso | 6 | 0.06 | 8.1e-06 | -5.0 | -5.2 | 2.0e-07 | 0.72 | 0.01 | 0.96 | FALSE |
| 6 | GTEx | Whole Blood | PSRC1 | 0.14 | 0.04 | lasso | 3 | 0.03 | 6.9e-04 | -5.7 | -5.8 | 5.4e-09 | 0.98 | 0.00 | 0.99 | TRUE |
| 7 | ROSMAP | Brain Pre-frontal Cortex | CELSR2 | 0.25 | 0.21 | lasso | 6 | 0.23 | 4.9e-29 | -5.6 | -5.5 | 4.4e-08 | 0.96 | 0.00 | 1.00 | FALSE |
| 8 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | PSRC1 | 0.12 | 0.11 | lasso | 4 | 0.09 | 4.5e-06 | -5.8 | -5.7 | 9.7e-09 | 0.96 | 0.00 | 0.99 | FALSE |
| 9 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | PSRC1 | 0.16 | 0.20 | lasso | 3 | 0.19 | 3.7e-09 | -5.9 | -5.8 | 5.4e-09 | 0.99 | 0.00 | 1.00 | FALSE |
| 10 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | SORT1 | 0.23 | 0.16 | lasso | 4 | 0.16 | 4.6e-08 | -5.7 | -5.4 | 7.9e-08 | 0.93 | 0.01 | 0.99 | FALSE |