Best TWAS P=3.61e-17 · Best GWAS P=4.32e-14 conditioned to 0.00757
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | KIAA1109 | 0.09 | 0.08 | bslmm | 390 | 0.08 | 8.9e-10 | 7.4 | -5.3 | 1.5e-07 | -0.91 | 0.01 | 0.99 | FALSE |
| 2 | GTEx | Artery Aorta | KIAA1109 | 0.11 | 0.00 | lasso | 7 | 0.01 | 5.1e-02 | 7.6 | -7.2 | 5.3e-13 | -0.88 | 0.02 | 0.89 | FALSE |
| 3 | GTEx | Artery Tibial | KIAA1109 | 0.16 | 0.07 | lasso | 6 | 0.05 | 5.1e-05 | 7.4 | -7.0 | 2.1e-12 | -0.97 | 0.01 | 0.99 | FALSE |
| 4 | GTEx | Brain Nucleus accumbens basal ganglia | KIAA1109 | 0.22 | 0.07 | lasso | 7 | 0.03 | 5.9e-02 | 7.4 | -7.2 | 8.6e-13 | -0.97 | 0.02 | 0.78 | FALSE |
| 5 | GTEx | Colon Transverse | KIAA1109 | 0.25 | -0.01 | enet | 16 | 0.00 | 4.1e-01 | 7.0 | -7.2 | 4.5e-13 | -0.86 | 0.02 | 0.72 | FALSE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | KIAA1109 | 0.08 | 0.08 | lasso | 7 | 0.07 | 2.5e-09 | 7.4 | -7.1 | 1.1e-12 | -0.98 | 0.01 | 0.99 | FALSE |
| 7 | The Cancer Genome Atlas | Breast Invasive Carcinoma | KIAA1109 | 0.03 | 0.03 | lasso | 1 | 0.02 | 1.2e-05 | 7.4 | -7.4 | 1.1e-13 | -0.99 | 0.00 | 1.00 | FALSE |
| 8 | The Cancer Genome Atlas | Esophageal Carcinoma | KIAA1109 | 0.32 | 0.02 | blup | 45 | 0.02 | 7.4e-02 | 7.0 | -8.4 | 3.6e-17 | -0.66 | 0.01 | 0.70 | TRUE |
| 9 | The Cancer Genome Atlas | Brain Lower Grade Glioma | KIAA1109 | 0.06 | 0.05 | lasso | 2 | 0.03 | 7.1e-05 | 7.4 | -7.6 | 2.9e-14 | -0.99 | 0.00 | 1.00 | FALSE |
| 10 | The Cancer Genome Atlas | Thyroid Carcinoma | KIAA1109 | 0.05 | 0.04 | enet | 3 | 0.05 | 5.4e-06 | 7.0 | -7.6 | 2.7e-14 | -0.95 | 0.01 | 0.99 | FALSE |