[Hub]/) : Traits : Asthma (self-reported) : ← →

chr4:38,097,478-39,643,536

Best TWAS P=4.15e-14 · Best GWAS P=3.55e-15 conditioned to 0.00405

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	TLR1	0.08	0.07	lasso	2	0.07	1.3e-08	-7.0	-7.4	1.5e-13	0.83	0.18	0.82	FALSE
2	GTEx	Cells Transformed fibroblasts	TLR6	0.28	0.19	lasso	5	0.17	1.7e-12	-6.4	6.5	1.0e-10	-0.71	0.94	0.06	FALSE
3	GTEx	Esophagus Mucosa	TLR1	0.20	0.02	lasso	6	0.04	9.8e-04	-6.4	6.9	5.4e-12	-0.78	0.05	0.94	FALSE
4	GTEx	Esophagus Muscularis	TLR1	0.21	0.02	enet	46	0.06	2.3e-04	-6.5	5.5	3.1e-08	-0.56	0.07	0.80	FALSE
5	GTEx	Skin Not Sun Exposed Suprapubic	TLR6	0.29	0.03	lasso	11	0.08	4.8e-05	2.7	6.1	1.4e-09	-0.68	0.13	0.84	FALSE
6	GTEx	Testis	FAM114A1	0.37	0.20	lasso	7	0.20	2.2e-09	-6.3	-5.4	8.1e-08	0.71	0.33	0.66	FALSE
7	ROSMAP	Brain Pre-frontal Cortex	TLR1	0.08	0.02	blup	514	0.03	2.3e-05	-6.7	-5.1	2.7e-07	0.68	0.17	0.80	FALSE
8	YFS	Blood	TLR1	0.08	0.05	bslmm	525	0.07	1.2e-20	-7.4	6.0	2.5e-09	-0.54	0.04	0.96	FALSE
9	YFS	Blood	TLR6	0.05	0.04	bslmm	505	0.06	1.3e-18	-6.9	5.8	8.6e-09	-0.61	0.53	0.47	FALSE
10	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TLR6	0.03	0.02	lasso	2	0.01	3.5e-02	-6.4	6.3	2.5e-10	-0.71	0.05	0.19	FALSE
11	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TLR1	0.04	0.03	lasso	4	0.03	8.2e-05	-7.4	7.6	4.1e-14	-0.83	0.05	0.95	TRUE
12	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	TLR10	0.09	0.06	lasso	2	0.06	2.3e-04	-5.7	5.7	1.1e-08	-0.68	0.12	0.30	FALSE
13	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	TLR1	0.14	0.07	enet	12	0.10	1.7e-05	-6.7	7.3	3.8e-13	-0.85	0.02	0.98	FALSE
14	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TLR1	0.03	0.03	enet	23	0.03	1.5e-04	-7.4	5.6	1.7e-08	-0.69	0.03	0.90	FALSE
15	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	TLR1	0.13	0.13	enet	3	0.08	2.6e-03	-4.6	5.9	4.3e-09	-0.71	0.02	0.58	FALSE