Best TWAS P=3.31e-13 · Best GWAS P=2.02e-12 conditioned to 0.000904
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | KDM8 | 0.13 | 0.05 | enet | 4 | 0.05 | 6.4e-05 | 6.0 | -5.7 | 1.3e-08 | -0.47 | 0.28 | 0.68 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | CTD-3203P2.1 | 0.12 | 0.01 | lasso | 7 | 0.02 | 9.2e-03 | 4.7 | -5.6 | 2.3e-08 | -0.52 | 0.22 | 0.48 | FALSE |
| 3 | GTEx | Nerve Tibial | CTD-3203P2.1 | 0.21 | 0.05 | lasso | 6 | 0.09 | 8.5e-07 | 6.4 | -7.1 | 1.1e-12 | -0.46 | 0.18 | 0.77 | TRUE |
| 4 | NTR | Blood | IL4R | 0.03 | 0.01 | enet | 10 | 0.01 | 8.1e-04 | 5.9 | -6.3 | 2.6e-10 | -0.61 | 0.26 | 0.65 | FALSE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | NSMCE1 | 0.07 | 0.03 | bslmm | 510 | 0.02 | 3.1e-03 | 6.0 | 6.2 | 4.8e-10 | 0.41 | 0.14 | 0.82 | FALSE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | CTD-3203P2.1 | 0.14 | 0.07 | enet | 24 | 0.07 | 2.3e-09 | 6.4 | -6.5 | 9.0e-11 | -0.46 | 0.13 | 0.87 | FALSE |
| 7 | YFS | Blood | IL4R | 0.13 | 0.04 | enet | 35 | 0.10 | 2.0e-32 | 6.3 | -7.3 | 3.3e-13 | -0.45 | 0.22 | 0.78 | TRUE |
| 8 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | JMJD5 | 0.04 | 0.04 | blup | 67 | 0.02 | 3.5e-03 | 6.4 | -6.7 | 2.0e-11 | -0.46 | 0.00 | 0.99 | FALSE |
| 9 | The Cancer Genome Atlas | Thyroid Carcinoma | JMJD5 | 0.04 | 0.01 | enet | 9 | 0.02 | 7.1e-03 | 6.3 | -5.4 | 6.2e-08 | -0.46 | 0.01 | 0.98 | FALSE |