Hub : Genes

EPM2AIP1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0270	0.0170	2.3e-02	0.009	0.012	0.016	NA	0.009	2.4e-02	1.1e-02	3.6e-03	NA	2.7e-02
2	YFS	Blood	0.1411	0.0351	2.9e-14	0.022	0.043	0.059	0.055	0.055	8.5e-08	5.2e-14	9.6e-19	2.2e-17	1.8e-17
3	TCGA	Kidney Renal Clear Cell Carcinoma	0.0641	0.0358	8.5e-03	0.014	0.004	0.004	NA	0.012	9.0e-03	1.2e-01	9.9e-02	NA	1.5e-02
4	TCGA	Thyroid Carcinoma	0.0380	0.0230	2.7e-05	0.042	0.040	0.036	NA	0.037	5.4e-05	8.3e-05	1.8e-04	NA	1.5e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	4.2	6.6	12.7	-1.6	3.3	-0.4	3.6
Bipolar Disorder or Schizophrenia	3.4	8.2	16.9	-2.7	2.9	0.0	4.1
Depressed Affect (Nagel 2018)	0.1	0.1	0.4	-0.3	0.6	0.4	-0.1
Depression (Nagel 2018)	0.6	0.9	1.6	-0.2	-1.0	1.3	-1.0
Intelligence (Savage-Jansen 2018)	0.2	0.8	2.0	-0.6	-0.8	0.2	-1.4
Neuroticism (Nagel 2018)	0.3	0.6	0.9	-0.9	0.5	0.9	0.7
Schizophrenia (2018)	1.4	2.9	5.8	-2.1	1.2	0.3	2.4
Schizophrenia vs Biploar Disorder	1.2	1.5	3.4	-0.2	-1.9	0.7	-1.5
Worry (Nagel 2018)	0.7	1.5	2.8	-1.7	0.3	1.4	1.1
Alzheimer’s Disease (in mother)	1.2	1.4	3.5	-0.7	1.9	-0.7	1.1
Alzheimer’s Disease (in father)	1.9	2.0	5.4	-0.3	2.3	0.6	1.6
Alzheimer’s Disease (including proxy)	2.4	3.5	8.5	-1.2	2.9	-0.6	1.9
Crohns Disease (2017)	0.7	1.6	4.0	2.0	-0.4	-0.3	-1.5
Irritable Bowel Disease (IBD)	0.3	0.8	2.5	1.6	0.3	-0.1	0.7
Ulcerative Colitis (UC)	1.1	2.0	7.3	0.2	0.9	-0.0	2.7
Major Depression (MDD)	0.0	0.0	0.0	0.2	0.2	-0.2	-0.2
Reaction Time	0.3	0.6	0.8	-0.5	0.9	0.8	0.9
Verbal and Numeric Reasoning (VNR)	0.7	1.6	5.0	0.2	-1.2	-0.1	-2.2
Breast Cancer	1.3	3.0	4.8	-1.8	2.1	0.1	2.2
Ovarian Cancer	0.4	0.6	1.1	-0.3	1.1	-0.8	0.7
Prostate Cancer	0.2	0.3	0.8	-0.5	0.2	-0.0	0.9
Age at First Birth	0.3	0.4	1.1	-0.4	0.5	-0.1	1.1
Bipolar Disorder (2011)	0.4	0.4	0.6	-0.6	0.8	0.0	0.8
Body Mass Index (BMI) (2010)	1.5	2.0	5.6	-0.4	-2.4	-1.0	-1.1
Coronary Artery Disease (CAD)	1.1	1.3	2.6	1.0	-1.0	-0.6	-1.6
Crohns Disease (2012)	1.5	2.4	5.2	2.3	-0.8	-0.6	-1.8
Mean Putamen Volume	0.9	1.1	2.0	1.0	-1.1	0.2	-1.4
Fasting Glucose	0.3	0.4	1.3	0.3	0.1	1.2	-0.2
HbA1C	0.4	0.4	1.2	1.1	0.2	0.6	0.2
HDL Cholesterol	2.8	4.7	9.7	-1.5	3.1	1.8	1.9
LDL Cholesterol	0.8	1.3	2.8	0.6	-1.7	0.1	-1.4
Lupus	0.4	0.6	1.4	-1.0	0.1	-0.3	1.2
Neuroticism (2016)	1.3	1.9	4.3	-1.7	2.1	-0.5	0.5
Primary Biliary Cirrhosis	0.1	0.1	0.2	0.4	-0.3	0.3	-0.1
Rheumatoid Arthritis	1.4	1.9	4.8	1.0	-2.2	-1.0	-0.9
Schizophrenia (2014)	2.1	4.6	8.6	-2.0	2.1	1.1	2.9
Triglycerides	2.3	3.7	6.6	1.0	-2.0	-2.6	-1.9
Type 2 Diabetes (T2D) (2012)	0.4	0.5	0.9	0.5	-1.0	0.1	-0.9
Ulcerative Colitis	0.5	0.8	2.5	0.6	0.3	-0.3	1.6
Blood Eosinophil Count	0.2	1.9	5.3	-0.7	0.1	-2.3	1.3
Blood Platelet Count	0.1	1.3	3.8	-1.0	-0.2	0.7	2.0
Blood Red Count	0.1	0.7	2.6	-1.6	-0.3	-0.0	0.1
Blood White Count	0.3	2.4	4.9	-2.0	-0.8	-0.3	2.2
Heel T-Score	0.9	7.1	10.0	-3.0	2.8	-3.2	1.2
BMI	1.0	5.6	9.9	-0.4	-2.0	-3.1	-2.9
Height	1.2	22.2	49.8	5.7	-2.5	-0.1	-7.1
Waist Hip Ratio (WHR)	0.3	1.3	4.2	-2.0	-0.0	-0.7	-0.8
Systolic Blood Pressure	0.5	2.3	5.9	0.5	-1.4	-1.0	-2.4
Smoking Status	0.3	0.8	1.5	-0.1	-1.2	1.2	-0.5
Allergy or Eczema	0.3	0.7	1.9	1.4	0.4	0.1	0.9
Cardiovascular Disease	0.8	2.5	3.1	-1.8	-1.7	-1.6	-1.2
Hypothyroidism (self reported)	3.9	9.1	29.5	1.2	-2.3	0.1	-5.4
Respiratory disease	1.7	3.7	7.3	-0.5	2.7	0.7	2.6
Type 2 Diabetes (T2D) (2018)	1.3	2.5	4.5	1.1	-2.1	-0.5	-2.0
Lung FEV1/FVC ratio	1.0	5.1	12.0	0.1	-2.1	-2.0	-3.5
Lung FVC	1.0	5.2	13.3	-2.5	0.5	-1.0	3.6
Neuroticism	0.4	1.0	2.1	-1.4	0.8	0.6	1.0
Chronotype (morning person)	1.8	4.2	15.0	-0.1	-0.5	-3.9	-1.3
Hair Pigment	0.0	0.2	0.3	-0.6	0.3	0.5	0.5
Tanning	0.2	2.1	5.2	-1.7	0.2	-2.3	0.6
Hand grip strength (left)	0.1	0.4	1.2	0.5	-0.1	-1.1	0.1
Number of treatments/medications taken	0.4	0.7	1.8	0.4	-0.1	0.9	-1.4
Average weekly spirits intake	1.6	2.0	5.1	-2.3	0.5	-0.8	1.4
Sensitivity / hurt feelings	0.9	1.5	2.0	-0.4	1.4	1.4	1.4
Frequency of depressed mood in last 2 weeks	0.3	0.4	0.9	-0.6	0.0	0.9	0.5
Hearing difficulty/problems: Yes	0.6	0.8	3.3	1.8	-0.1	0.3	0.1
Relative age of first facial hair	0.6	1.3	2.2	1.3	0.2	1.5	-1.1
Other serious medical condition/disability diagnosed by doctor	1.8	2.3	4.9	1.3	-0.2	1.6	-2.2
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.8	0.1	0.1	0.9	0.6
Ever had hysterectomy (womb removed)	1.8	2.1	7.0	-1.0	-2.7	-0.5	0.1
Systolic blood pressure, automated reading	1.3	3.7	9.2	1.4	-1.8	-0.6	-3.0
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.6	0.4	-0.2	0.6	-0.8
Angina	1.4	1.8	3.1	-0.7	1.8	1.1	1.5
Medication for hormone replacement therapy	0.1	0.1	0.2	0.4	-0.1	0.2	-0.2
Vitamin and mineral supplements	0.7	1.0	2.8	-1.7	-0.8	0.6	0.2
Supplements: Zinc	1.3	1.4	4.3	0.1	2.1	0.1	1.2
Medication: Co-codamol	0.3	0.4	1.4	-0.1	-0.4	1.2	-0.1
Medication: Metformin	0.8	1.1	3.2	0.5	-1.8	-0.2	-1.0
Diabetes (father)	0.1	0.2	0.5	0.3	-0.7	-0.1	-0.3
Diabetes (mother)	3.7	4.7	11.9	1.7	-2.0	0.1	-3.5
Severe depression (siblings)	0.4	0.5	0.7	-0.8	0.4	-0.8	0.8
Pack years adult smoking proportion	0.3	0.4	1.0	-0.2	0.1	-1.0	-0.7
Impedance of leg (right)	0.1	0.6	1.4	0.1	0.8	1.2	0.6
Leg fat-free mass (left)	1.2	6.3	10.0	1.9	-1.8	-2.9	-3.2
Trunk fat percentage	3.2	12.9	29.5	1.6	-3.4	-2.8	-5.4
Hand grip strength (right)	0.3	0.8	1.0	0.6	1.0	-0.9	1.0
Townsend deprivation index at recruitment	0.1	0.1	0.4	0.3	-0.3	0.6	0.0
Current tobacco smoking	1.4	2.3	4.7	2.2	-1.6	0.9	-1.1
Average weekly fortified wine intake	0.4	0.5	0.7	0.6	0.7	0.9	-0.5
Maternal smoking around birth	1.2	1.7	3.8	0.2	-2.0	-1.4	-1.0
Fed-up feelings	0.2	0.4	0.8	-0.9	0.6	0.1	0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.6	2.0	1.4	-1.0	1.1	-1.4
Relative age voice broke	0.1	0.2	0.6	0.8	-0.2	-0.4	-0.1
Taking other prescription medications	0.7	1.1	4.0	0.4	-0.3	2.0	-0.4
Age when periods started (menarche)	0.7	1.8	4.1	0.6	-2.0	-0.3	-1.6
Bilateral oophorectomy (both ovaries removed)	0.2	0.3	0.7	-0.5	-0.2	0.3	0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.6	4.0	-1.0	0.9	-2.0	0.8
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.6	0.2	0.2	0.8	-0.3
Qualifications: CSEs or equivalent	1.3	1.8	6.9	-0.2	0.5	0.0	2.6
Serious illness, injury or assault to yourself	0.1	0.1	0.2	-0.2	0.1	0.4	-0.2
High blood pressure	0.3	0.8	1.8	-1.4	-1.0	-0.4	-0.1
Hayfever, allergic rhinitis or eczema	0.2	0.4	1.1	1.1	-0.1	-0.1	0.5
Multivitamins +/- minerals	0.7	0.8	1.4	1.0	0.9	-1.2	0.4
Stomach or abdominal pain in last month	2.0	2.5	6.1	-0.8	2.5	0.4	1.8
Supplements: Glucosamine	0.7	0.9	2.0	0.9	0.8	1.4	0.3
Diverticular disease/diverticulitis (self-reported)	0.8	0.9	1.8	-0.8	-1.0	-0.2	1.4
Medication: Atenolol	0.7	0.8	1.5	-1.2	0.9	-0.9	0.5
Medication: Levothyroxine sodium	4.3	7.3	20.5	1.7	-2.2	0.9	-4.5
Sitting height	0.5	3.4	6.3	2.5	-1.1	-1.4	-2.0
Chronic bronchitis/emphysema (father)	1.0	1.1	1.6	0.5	-1.2	-1.3	-1.2
High blood pressure (mother)	0.3	0.4	1.0	0.5	-0.6	0.3	-1.0
Body mass index (BMI)	0.7	2.9	4.7	0.5	-1.5	-2.2	-2.1
Impedance of leg (left)	0.2	1.0	3.3	0.3	0.6	1.8	0.5
Leg predicted mass (left)	1.2	6.5	10.4	2.0	-1.8	-2.9	-3.2
Trunk fat mass	3.1	13.4	29.7	2.0	-3.3	-3.0	-5.5
Waist circumference	1.3	4.7	10.9	0.5	-1.8	-2.1	-3.3
Number of incorrect matches in round	0.1	0.2	0.5	0.3	-0.5	-0.7	0.1
Past tobacco smoking	0.4	0.7	1.6	1.3	-0.8	-0.5	-0.5
Alcohol usually taken with meals	0.4	0.6	1.4	1.2	0.9	-0.3	-0.3
Nervous feelings	0.1	0.2	0.3	0.3	0.5	0.3	0.5
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.4	0.7	0.5	0.7	0.2	0.9
Hearing difficulty/problems with background noise	0.1	0.2	0.6	0.8	0.1	0.2	0.1
Hair/balding pattern: Pattern 2	0.5	0.6	2.0	-1.4	-0.2	-0.6	-0.0
Had menopause	0.7	0.9	1.7	-0.9	-1.3	-0.2	-1.0
Had other major operations	2.2	2.7	7.4	1.2	-1.0	1.0	-2.7
Forced vital capacity (FVC)	0.3	1.2	2.9	-0.4	-0.1	-1.7	1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.8	1.9	0.0	1.1	-1.4	0.1
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	2.7	-1.6	-0.4	-0.7	0.6
Qualifications: None of the above	0.7	1.5	4.8	2.2	0.9	-0.2	-0.4
Financial difficulties in last 2 years	0.3	0.4	1.4	1.2	0.1	0.5	-0.3
Mouth/teeth dental problems	0.2	0.3	0.7	-0.2	0.8	-0.8	-0.2
Heart attack	0.5	0.7	2.3	1.5	-0.0	0.5	-0.3
Allergy	0.3	0.6	1.1	-0.8	-0.8	0.0	-1.0
Pain all over the body in last month	0.2	0.2	0.4	0.4	0.6	-0.3	0.1
Diabetes (self-reported)	0.9	1.4	4.7	-0.2	-2.2	-0.3	-1.0
Hayfever/allergic rhinitis (self-reported)	0.6	0.9	2.0	-0.9	-0.5	-1.4	0.5
Medication: Ramipril	0.3	0.3	0.4	0.3	-0.6	0.7	-0.7
Medication: Simvastatin	1.2	1.7	2.6	-1.6	-1.6	-1.1	-0.6
Fluid intelligence score	0.7	1.4	3.8	-0.1	-0.8	-1.0	-2.0
Illnesses of siblings	0.8	1.2	2.9	-0.8	0.8	-0.6	1.7
Neuroticism score	0.3	0.7	1.3	-1.1	0.9	-0.3	0.7
Weight	1.7	8.2	16.0	2.3	-2.2	-2.6	-4.0
Impedance of arm (right)	0.4	2.1	5.9	1.2	-0.6	0.8	-2.4
Arm fat percentage (right)	2.1	8.2	16.4	1.0	-2.8	-2.7	-4.0
Trunk fat-free mass	0.8	4.5	7.6	2.8	-0.9	-2.2	-2.2
Hip circumference	1.6	6.9	12.2	2.1	-2.1	-2.5	-3.5
Time employed in main current job	1.0	1.2	2.0	-1.4	0.7	0.6	1.4
Alcohol intake versus 10 years previously	0.5	0.7	1.7	0.1	0.5	0.9	1.3
Father’s age at death	0.6	0.7	1.6	-0.4	0.2	-1.3	-1.1
Worrier / anxious feelings	0.5	0.9	2.0	-0.7	0.6	1.4	0.8
Frequency of tiredness / lethargy in last 2 weeks	0.0	0.1	0.1	0.4	-0.2	0.1	0.0
Falls in the last year	1.2	1.6	4.5	1.3	0.0	0.3	-2.1
Hair/balding pattern: Pattern 3	1.1	1.7	2.6	1.2	1.1	1.6	1.3
Number of live births	1.7	2.5	5.2	-0.6	-2.3	-1.9	-0.8
Forced expiratory volume in 1-second (FEV1)	0.4	1.2	3.5	-0.4	-0.9	-1.9	0.6
Pulse rate	0.9	1.5	4.3	2.1	0.3	1.1	0.5
Happiness	0.7	0.8	1.2	1.1	1.1	0.9	0.1
Noisy workplace	0.9	1.1	2.3	-0.3	1.5	0.2	1.5
Qualifications: A levels/AS levels or equivalent	0.8	1.8	4.4	-1.6	-0.2	-2.1	0.3
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	3.0	0.0	-0.2	1.7	-0.1
Mouth/teeth dental problems: Dentures	0.5	0.8	2.4	0.9	-0.4	-0.1	-1.5
Asthma	1.2	2.3	4.8	-0.8	2.2	0.2	1.9
Medication: Ibuprofen (e.g. Nurofen)	1.4	1.7	4.6	0.1	1.0	2.1	1.2
Medication: Cholesterol lowering	0.8	1.2	1.9	-0.8	-1.2	-1.4	-1.0
Depression (self-reported)	0.6	0.7	1.5	-1.2	0.8	0.7	0.5
Medication: Lansoprazole	0.2	0.2	0.4	-0.7	0.5	-0.0	0.4
Prospective memory result	2.1	2.6	4.5	1.6	-1.9	-0.0	-2.1
Lung cancer (father)	1.1	1.3	3.4	1.8	1.0	-0.7	0.4
Illnesses of mother	1.1	1.4	3.1	-0.6	1.8	0.2	1.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.8	6.0	-0.3	-0.6	-2.4	0.8
Pulse wave Arterial Stiffness index	1.0	1.2	2.5	0.5	-1.6	-1.1	-0.9
Impedance of arm (left)	0.3	1.5	4.5	0.5	-0.8	0.9	-2.1
Arm fat mass (right)	2.1	8.5	17.5	1.6	-2.7	-2.6	-4.2
Trunk predicted mass	0.8	4.4	7.5	2.7	-0.9	-2.1	-2.2
Standing height	1.2	11.8	23.1	4.4	-1.9	-1.1	-4.8
Length of working week for main job	0.7	0.8	1.5	0.9	-0.4	0.8	-1.2
Exposure to tobacco smoke at home	0.6	0.6	1.1	0.3	-0.9	-0.7	-1.1
Breastfed as a baby	0.7	0.9	2.7	1.6	0.7	-0.4	0.4
Tense / ‘highly strung’	0.3	0.5	1.6	-1.2	0.6	-0.2	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.7	-0.8	0.1	0.3	-0.6
Hair/balding pattern: Pattern 4	0.4	0.9	3.6	-1.9	-0.0	-0.3	0.3
Birth weight of first child	0.7	1.2	4.2	2.0	-0.7	0.4	-0.0
Peak expiratory flow (PEF)	0.7	1.6	6.2	-0.6	-0.2	-2.5	0.2
Pulse wave reflection index	1.3	1.6	3.6	-0.1	-1.1	-1.4	-1.9
Ever highly irritable/argumentative for 2 days	1.4	1.7	2.9	1.7	-1.4	0.4	-1.3
Loud music exposure frequency	2.1	2.3	5.6	1.9	0.0	2.4	-0.0
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	3.3	-1.8	0.1	-0.8	1.1
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	1.3	-1.2	-0.7	0.0	0.8
Blood clot in the leg (DVT)	0.3	0.4	1.2	1.1	-0.1	0.1	-0.7
Medication: Paracetamol	0.3	0.6	1.4	-0.2	-1.2	0.2	-0.9
Headache pain in last month	0.5	0.9	1.6	0.7	1.3	1.1	0.6
Medication for cholesterol, blood pressure or diabetes	0.6	0.9	1.8	0.9	1.3	0.8	0.7
Glaucoma (self-reported)	2.3	2.7	4.7	1.9	-1.1	-1.1	-2.2
Gout (self-reported)	0.5	0.7	1.5	-0.2	-1.1	-1.2	-0.4
Hypothyroidism/myxoedema (self-reported)	5.1	10.0	29.5	1.3	-3.0	0.5	-5.4
Medication: Amlodipine	0.3	0.4	0.9	0.8	0.5	0.0	-1.0
Medication: Ventolin 100micrograms inhaler	1.1	1.4	2.2	-1.3	1.1	0.8	1.5
Birth weight	0.6	1.4	2.0	1.1	-1.4	-1.3	-0.9
Chronic bronchitis/emphysema (mother)	0.1	0.2	0.6	-0.8	-0.3	0.2	-0.0
High blood pressure (siblings)	2.1	3.0	5.4	2.2	-0.9	0.9	-2.3
Forced vital capacity (FVC), Best measure	0.3	1.3	4.4	-0.1	-0.2	-2.1	0.8
Body fat percentage	2.5	10.0	22.3	1.5	-2.9	-2.7	-4.7
Leg fat percentage (right)	1.1	3.9	7.7	0.9	-1.3	-2.3	-2.8
Arm fat-free mass (right)	0.6	3.2	4.5	1.8	-1.0	-2.1	-2.0
Exposure to tobacco smoke outside home	0.5	0.7	1.8	1.3	-0.0	0.1	-1.0
Comparative body size at age 10	0.8	2.2	4.3	-1.5	1.5	0.2	2.1
Number of full brothers	0.4	0.5	0.8	0.1	-0.8	-0.8	-0.9
Worry too long after embarrassment	0.1	0.2	0.7	-0.3	-0.8	0.2	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.6	-0.8	0.1	0.5	-0.2
Wheeze or whistling in the chest in last year	0.8	1.4	2.9	0.0	1.7	1.5	0.7
Number of children fathered	1.3	1.5	3.3	0.5	-0.9	1.3	-1.8
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	1.4	-0.5	0.5	1.2	0.1
Age at first live birth	2.1	3.7	5.1	-1.9	2.3	1.6	1.9
Pulse wave peak to peak time	0.6	0.8	1.8	-0.3	1.4	0.9	0.5
Health satisfaction	1.5	1.9	4.8	2.2	-0.9	0.4	-1.4
Shortness of breath walking on level ground	0.4	0.4	1.5	0.1	-0.5	0.2	-1.2
Qualifications: College or University degree	0.2	0.7	2.1	-1.4	0.7	-0.2	-0.5
Eye problems/disorders: None of the above	0.8	1.0	2.1	-0.5	1.1	0.4	1.5
Mouth/teeth dental problems: Loose teeth	0.5	0.5	1.5	1.2	0.2	0.6	-0.5
Emphysema/chronic bronchitis	1.0	1.1	3.0	1.1	0.2	1.7	0.0
Medication for pain relief, constipation, heartburn	0.1	0.2	0.5	-0.3	-0.0	-0.7	0.3
Neck or shoulder pain in last month	1.3	1.8	3.6	-1.5	1.0	0.4	1.9
Medication: Blood pressure	0.3	0.5	1.0	-1.0	-0.4	-0.7	-0.5
Angina (self-reported)	1.4	1.9	3.3	-0.5	1.8	1.1	1.6
Migraine (self-reported)	0.5	0.6	1.6	-0.2	0.7	0.2	1.3
Medication: Ibuprofen	1.2	1.4	3.5	0.6	1.1	1.9	0.7
Medication: Allopurinol	1.0	1.4	3.6	-1.9	0.0	-1.1	0.8
Medication: Omeprazole	0.5	0.6	1.5	0.8	1.2	0.1	0.7
Medication: Seretide 50 evohaler	0.3	0.3	1.1	-1.0	0.1	-0.2	0.2
Mean time to correctly identify matches	0.2	0.4	1.1	0.4	0.1	1.1	0.4
Heart disease (mother)	4.0	4.9	10.0	1.5	-3.2	0.2	-2.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	0.7	-0.1	0.4	-0.9	0.6
Whole body fat mass	2.4	10.2	21.3	1.9	-2.7	-3.0	-4.6
Leg fat mass (right)	1.6	6.2	11.9	1.4	-1.9	-2.7	-3.5
Arm predicted mass (right)	0.8	3.9	5.2	2.1	-1.1	-2.3	-2.1
Pulse rate, automated reading	0.1	0.2	0.6	0.0	-0.8	0.3	0.3
Alcohol intake frequency.	0.2	0.6	1.2	0.4	-1.1	-1.0	-0.2
Comparative height size at age 10	0.7	3.7	7.3	1.8	-1.9	-0.8	-2.7
Number of full sisters	0.9	1.1	2.2	1.5	-1.1	0.3	-0.9
Suffer from ‘nerves’	0.6	0.9	1.8	-1.3	0.9	0.1	1.0
Overall health rating	0.2	0.5	1.0	1.0	-0.6	0.5	-0.6
Chest pain or discomfort	0.2	0.3	0.5	0.7	0.6	-0.3	0.4
Had major operations	0.5	0.6	1.5	1.2	0.1	-0.3	-0.8
Age at last live birth	0.8	1.1	3.7	-0.6	1.9	-0.5	0.5
Family relationship satisfaction	0.4	0.6	1.3	0.1	0.4	1.1	0.8
Leg pain on walking	1.7	2.1	4.2	2.0	-1.3	-0.1	-1.6
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.8	2.4	-0.1	-1.5	0.2	-0.8
Commuting to job workplace: Car/motor vehicle	0.4	0.4	1.6	0.1	-1.3	0.2	0.1
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	1.1	-0.7	-1.0	-1.0	-0.4
Medication: Aspirin	0.2	0.3	0.6	-0.1	0.3	0.7	-0.7
Supplements: Vitamin C	0.3	0.3	0.5	0.4	-0.1	-0.7	-0.7
Knee pain experienced in last month	1.2	1.9	3.6	0.8	-1.9	1.3	-1.3
Hypertension (Self-reported)	0.2	0.4	0.9	-1.0	-0.7	0.5	0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.9	-0.2	0.4	0.6	1.4
Illnesses of father: Heart disease	0.6	0.8	2.2	-1.1	-1.5	0.1	0.3
Illnesses of siblings: Diabetes	1.2	1.5	3.4	0.6	-1.5	0.2	-1.8
Smoking status: Previous	0.3	0.4	1.7	-1.3	0.3	0.1	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	1.2	2.4	5.3	2.3	-0.1	-1.7	-1.3
Whole body fat-free mass	0.9	5.0	6.8	2.4	-1.3	-2.4	-2.6
Leg fat-free mass (right)	1.0	5.4	9.0	1.9	-1.7	-2.4	-3.0
Arm fat percentage (left)	2.0	7.8	15.7	0.9	-2.8	-2.7	-4.0
Average weekly red wine intake	0.3	0.4	1.1	-0.4	0.5	-1.0	-0.1
Handedness (chirality/laterality): Left-handed	0.3	0.4	0.7	0.9	-0.7	-0.6	0.2
Mood swings	0.2	0.4	0.5	-0.4	0.7	-0.6	0.7
Loneliness, isolation	0.8	1.1	3.7	0.6	1.9	-0.4	-0.1
Long-standing illness, disability or infirmity	0.6	0.9	2.5	0.9	-0.4	0.4	-1.6
Ever had bowel cancer screening	0.3	0.3	0.7	0.4	0.8	0.3	0.5
Diabetes diagnosed by doctor	1.4	2.3	7.6	-0.3	-2.8	-0.5	-1.2
Ever had stillbirth, spontaneous miscarriage or termination	0.9	0.9	1.9	0.2	1.4	0.5	1.2
Friendships satisfaction	0.4	0.5	1.1	1.1	0.9	0.3	-0.3
Qualifications: nursing, teaching	0.9	1.4	3.0	-1.7	-0.7	-0.6	-1.3
Commuting to job workplace: Walk	1.2	1.3	3.6	0.4	-1.1	-0.3	-1.9
Eye problems/disorders: Cataract	0.3	0.4	0.7	0.5	0.8	-0.2	-0.8
Mouth/teeth dental problems: Mouth ulcers	1.2	1.9	4.5	-1.0	0.8	1.2	2.1
Medication for cholesterol	0.3	0.5	0.9	0.8	0.4	-0.9	0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	1.4	0.2	-1.2	0.5	-1.1
Back pain experienced in last month	1.6	2.4	6.5	-0.2	-1.0	2.5	1.4
Mineral and other dietary supplements	0.5	0.6	1.0	-1.0	-0.5	0.6	1.0
Breast cancer (self-reported)	1.5	1.8	4.2	-2.0	-1.4	-0.4	-1.0
Asthma (self-reported)	1.3	2.7	6.2	-0.5	2.5	0.3	2.0
Osteoporosis (self-reported)	1.5	1.9	3.4	0.8	-1.8	-0.6	-1.8
Osteoarthritis (self-reported)	0.2	0.3	0.7	0.4	0.4	0.9	-0.1
Medication: Aspirin	0.2	0.2	0.8	0.0	0.1	0.3	-0.9
Medication: Gliclazide	3.6	4.1	8.7	-0.3	-2.6	-0.8	-3.0
Illnesses of father: None of the above (group 1)	1.3	1.7	4.7	0.4	2.2	0.7	1.1
Smoking status: Current	1.0	1.6	4.0	2.0	-0.9	1.2	-0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.4	2.8	-0.3	0.5	-1.7	1.5
Whole body water mass	0.8	4.8	6.8	2.3	-1.2	-2.4	-2.6
Leg predicted mass (right)	1.1	5.7	9.9	1.9	-1.8	-2.5	-3.1
Arm fat mass (left)	1.9	7.8	15.3	1.4	-2.6	-2.7	-3.9
Number of self-reported non-cancer illnesses	0.4	0.6	1.2	0.5	0.8	1.1	-0.5
Average weekly champagne plus white wine intake	0.2	0.3	0.5	0.4	0.6	-0.2	0.7
Miserableness	0.1	0.2	0.7	-0.2	0.8	-0.2	0.3
Guilty feelings	0.3	0.5	1.2	-0.2	-0.2	-0.9	1.1
Wears glasses or contact lenses	1.8	2.1	5.2	0.4	-1.7	-0.2	-2.3
Ever taken oral contraceptive pill	0.5	0.5	1.6	1.3	-0.1	0.7	-0.3
Hearing aid user	0.4	0.4	1.3	-0.0	-1.1	-0.2	-0.6
Mother’s age at death	0.1	0.1	0.4	0.6	-0.1	0.3	-0.3
Financial situation satisfaction	0.2	0.3	0.9	0.1	0.9	0.3	0.4
Tinnitus: Yes, now most or all of the time	1.5	1.8	3.3	-1.4	1.8	-0.6	1.2
Commuting to job workplace: Public transport	0.7	0.8	1.5	1.0	0.1	-1.2	-0.8
Eye problems/disorders: Glaucoma	4.3	5.1	8.5	1.8	-2.2	-2.0	-2.9
Medication: Blood pressure	0.2	0.3	0.8	-0.6	0.0	0.9	-0.0
Pain type(s) experienced in last month: Hip pain	0.5	0.7	1.2	0.6	1.1	0.6	0.9
Supplements: Fish oil (including cod liver oil)	0.8	1.1	2.0	1.2	1.4	-0.2	-0.9
High cholesterol (Self-reported)	0.4	0.8	2.0	-0.6	-1.4	-0.3	-0.8
Medication: Bendroflumethiazide	0.3	0.4	1.3	-1.1	-0.4	0.3	0.1
Medication: Paracetamol	0.2	0.2	0.5	0.1	-0.7	-0.1	-0.6
Medication: Lisinopril	0.5	0.6	1.5	-0.8	0.4	-1.2	0.5
Medication: Atorvastatin	0.5	0.6	1.5	0.7	-0.2	0.5	-1.2
Illnesses of father: High blood pressure	0.7	0.9	1.9	-0.5	-1.0	1.4	-0.6
Alcohol drinker status: Never	2.7	3.2	8.1	0.7	-1.2	-2.9	-1.7
Ever smoked	0.4	0.7	1.3	-1.2	0.7	0.3	0.8
Basal metabolic rate	1.0	5.6	8.6	2.3	-1.5	-2.5	-2.9
Leg fat percentage (left)	1.1	3.9	8.4	1.0	-1.6	-1.9	-2.9
Arm fat-free mass (left)	0.9	4.3	6.7	2.6	-1.1	-1.8	-2.5
Number of operations (self-reported)	1.1	1.7	3.9	1.1	-0.8	1.0	-2.0
Average weekly beer plus cider intake	0.6	0.8	1.9	-0.5	-0.8	-1.4	0.7
Irritability	0.8	1.4	3.8	0.3	1.9	1.1	0.8
Risk taking	1.9	2.8	5.8	-0.1	2.0	1.1	2.4
Ever had prostate specific antigen (PSA) test	0.9	1.0	2.1	1.4	-0.2	-0.3	-1.5
Fractured/broken bones in last 5 years	0.6	0.8	1.7	-1.3	0.6	0.4	-1.1
Age started oral contraceptive pill	0.3	0.4	1.1	0.2	0.2	-0.5	-1.1
Diastolic blood pressure, automated reading	0.4	1.2	2.0	-1.4	0.7	-0.5	1.4
Ever depressed for a whole week	1.5	1.9	2.5	-1.6	-1.6	-1.4	0.9
Unable to work because of sickness or disability	2.6	3.4	8.1	2.0	0.7	2.9	-1.0
Commuting to job workplace: Cycle	0.9	1.1	2.9	0.6	1.7	0.8	0.8
Myopia	0.7	1.1	3.6	-0.1	-0.7	1.9	-0.3
Vascular/heart problems diagnosed by doctor	0.2	0.5	1.6	1.2	0.3	-0.2	-0.4
Cholesterol lowering medication	0.4	0.6	1.2	-0.7	-0.8	1.1	-0.1
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	1.4	1.1	1.2	0.2	0.8
Pain experienced in last month	0.5	0.8	2.4	-0.7	0.5	-1.6	0.2
Supplements: Calcium	0.1	0.1	0.3	0.2	-0.4	0.2	0.6
Basal cell carcinoma (self-reported)	1.6	1.9	4.7	0.3	-1.4	-0.9	-2.2
Heart attack/myocardial infarction (self-reported)	0.5	0.6	2.2	1.5	-0.1	0.5	-0.3
Deep venous thrombosis (DVT) (self-reported)	0.3	0.3	0.8	0.9	-0.1	0.2	-0.7
Heart disease (siblings)	0.5	0.6	1.4	-0.6	-1.2	-0.6	-0.6
Alcohol drinker status: Previous	0.5	0.6	1.2	0.3	-1.1	-0.3	-1.0
Pack years of smoking	0.5	0.7	1.9	-0.4	0.1	-1.4	-0.8
Impedance of whole body	0.2	1.1	2.0	0.7	-0.2	1.4	-1.3
Leg fat mass (left)	1.7	6.5	12.9	1.5	-2.1	-2.6	-3.6
Arm predicted mass (left)	0.9	4.5	7.2	2.7	-1.0	-1.8	-2.5