Hub : Genes

EPM2AIP1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0270 0.0170 2.3e-02 0.009 0.012 0.016 NA 0.009 2.4e-02 1.1e-02 3.6e-03 NA 2.7e-02
2 YFS Blood 0.1411 0.0351 2.9e-14 0.022 0.043 0.059 0.055 0.055 8.5e-08 5.2e-14 9.6e-19 2.2e-17 1.8e-17
3 TCGA Kidney Renal Clear Cell Carcinoma 0.0641 0.0358 8.5e-03 0.014 0.004 0.004 NA 0.012 9.0e-03 1.2e-01 9.9e-02 NA 1.5e-02
4 TCGA Thyroid Carcinoma 0.0380 0.0230 2.7e-05 0.042 0.040 0.036 NA 0.037 5.4e-05 8.3e-05 1.8e-04 NA 1.5e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 4.2 6.6 12.7 -1.6 3.3 -0.4 3.6
Bipolar Disorder or Schizophrenia 3.4 8.2 16.9 -2.7 2.9 0.0 4.1
Depressed Affect (Nagel 2018) 0.1 0.1 0.4 -0.3 0.6 0.4 -0.1
Depression (Nagel 2018) 0.6 0.9 1.6 -0.2 -1.0 1.3 -1.0
Intelligence (Savage-Jansen 2018) 0.2 0.8 2.0 -0.6 -0.8 0.2 -1.4
Neuroticism (Nagel 2018) 0.3 0.6 0.9 -0.9 0.5 0.9 0.7
Schizophrenia (2018) 1.4 2.9 5.8 -2.1 1.2 0.3 2.4
Schizophrenia vs Biploar Disorder 1.2 1.5 3.4 -0.2 -1.9 0.7 -1.5
Worry (Nagel 2018) 0.7 1.5 2.8 -1.7 0.3 1.4 1.1
Alzheimer’s Disease (in mother) 1.2 1.4 3.5 -0.7 1.9 -0.7 1.1
Alzheimer’s Disease (in father) 1.9 2.0 5.4 -0.3 2.3 0.6 1.6
Alzheimer’s Disease (including proxy) 2.4 3.5 8.5 -1.2 2.9 -0.6 1.9
Crohns Disease (2017) 0.7 1.6 4.0 2.0 -0.4 -0.3 -1.5
Irritable Bowel Disease (IBD) 0.3 0.8 2.5 1.6 0.3 -0.1 0.7
Ulcerative Colitis (UC) 1.1 2.0 7.3 0.2 0.9 -0.0 2.7
Major Depression (MDD) 0.0 0.0 0.0 0.2 0.2 -0.2 -0.2
Reaction Time 0.3 0.6 0.8 -0.5 0.9 0.8 0.9
Verbal and Numeric Reasoning (VNR) 0.7 1.6 5.0 0.2 -1.2 -0.1 -2.2
Breast Cancer 1.3 3.0 4.8 -1.8 2.1 0.1 2.2
Ovarian Cancer 0.4 0.6 1.1 -0.3 1.1 -0.8 0.7
Prostate Cancer 0.2 0.3 0.8 -0.5 0.2 -0.0 0.9
Age at First Birth 0.3 0.4 1.1 -0.4 0.5 -0.1 1.1
Bipolar Disorder (2011) 0.4 0.4 0.6 -0.6 0.8 0.0 0.8
Body Mass Index (BMI) (2010) 1.5 2.0 5.6 -0.4 -2.4 -1.0 -1.1
Coronary Artery Disease (CAD) 1.1 1.3 2.6 1.0 -1.0 -0.6 -1.6
Crohns Disease (2012) 1.5 2.4 5.2 2.3 -0.8 -0.6 -1.8
Mean Putamen Volume 0.9 1.1 2.0 1.0 -1.1 0.2 -1.4
Fasting Glucose 0.3 0.4 1.3 0.3 0.1 1.2 -0.2
HbA1C 0.4 0.4 1.2 1.1 0.2 0.6 0.2
HDL Cholesterol 2.8 4.7 9.7 -1.5 3.1 1.8 1.9
LDL Cholesterol 0.8 1.3 2.8 0.6 -1.7 0.1 -1.4
Lupus 0.4 0.6 1.4 -1.0 0.1 -0.3 1.2
Neuroticism (2016) 1.3 1.9 4.3 -1.7 2.1 -0.5 0.5
Primary Biliary Cirrhosis 0.1 0.1 0.2 0.4 -0.3 0.3 -0.1
Rheumatoid Arthritis 1.4 1.9 4.8 1.0 -2.2 -1.0 -0.9
Schizophrenia (2014) 2.1 4.6 8.6 -2.0 2.1 1.1 2.9
Triglycerides 2.3 3.7 6.6 1.0 -2.0 -2.6 -1.9
Type 2 Diabetes (T2D) (2012) 0.4 0.5 0.9 0.5 -1.0 0.1 -0.9
Ulcerative Colitis 0.5 0.8 2.5 0.6 0.3 -0.3 1.6
Blood Eosinophil Count 0.2 1.9 5.3 -0.7 0.1 -2.3 1.3
Blood Platelet Count 0.1 1.3 3.8 -1.0 -0.2 0.7 2.0
Blood Red Count 0.1 0.7 2.6 -1.6 -0.3 -0.0 0.1
Blood White Count 0.3 2.4 4.9 -2.0 -0.8 -0.3 2.2
Heel T-Score 0.9 7.1 10.0 -3.0 2.8 -3.2 1.2
BMI 1.0 5.6 9.9 -0.4 -2.0 -3.1 -2.9
Height 1.2 22.2 49.8 5.7 -2.5 -0.1 -7.1
Waist Hip Ratio (WHR) 0.3 1.3 4.2 -2.0 -0.0 -0.7 -0.8
Systolic Blood Pressure 0.5 2.3 5.9 0.5 -1.4 -1.0 -2.4
Smoking Status 0.3 0.8 1.5 -0.1 -1.2 1.2 -0.5
Allergy or Eczema 0.3 0.7 1.9 1.4 0.4 0.1 0.9
Cardiovascular Disease 0.8 2.5 3.1 -1.8 -1.7 -1.6 -1.2
Hypothyroidism (self reported) 3.9 9.1 29.5 1.2 -2.3 0.1 -5.4
Respiratory disease 1.7 3.7 7.3 -0.5 2.7 0.7 2.6
Type 2 Diabetes (T2D) (2018) 1.3 2.5 4.5 1.1 -2.1 -0.5 -2.0
Lung FEV1/FVC ratio 1.0 5.1 12.0 0.1 -2.1 -2.0 -3.5
Lung FVC 1.0 5.2 13.3 -2.5 0.5 -1.0 3.6
Neuroticism 0.4 1.0 2.1 -1.4 0.8 0.6 1.0
Chronotype (morning person) 1.8 4.2 15.0 -0.1 -0.5 -3.9 -1.3
Hair Pigment 0.0 0.2 0.3 -0.6 0.3 0.5 0.5
Tanning 0.2 2.1 5.2 -1.7 0.2 -2.3 0.6
Hand grip strength (left) 0.1 0.4 1.2 0.5 -0.1 -1.1 0.1
Number of treatments/medications taken 0.4 0.7 1.8 0.4 -0.1 0.9 -1.4
Average weekly spirits intake 1.6 2.0 5.1 -2.3 0.5 -0.8 1.4
Sensitivity / hurt feelings 0.9 1.5 2.0 -0.4 1.4 1.4 1.4
Frequency of depressed mood in last 2 weeks 0.3 0.4 0.9 -0.6 0.0 0.9 0.5
Hearing difficulty/problems: Yes 0.6 0.8 3.3 1.8 -0.1 0.3 0.1
Relative age of first facial hair 0.6 1.3 2.2 1.3 0.2 1.5 -1.1
Other serious medical condition/disability diagnosed by doctor 1.8 2.3 4.9 1.3 -0.2 1.6 -2.2
Ever used hormone-replacement therapy (HRT) 0.2 0.3 0.8 0.1 0.1 0.9 0.6
Ever had hysterectomy (womb removed) 1.8 2.1 7.0 -1.0 -2.7 -0.5 0.1
Systolic blood pressure, automated reading 1.3 3.7 9.2 1.4 -1.8 -0.6 -3.0
Eye problems/disorders: Diabetes related eye disease 0.3 0.3 0.6 0.4 -0.2 0.6 -0.8
Angina 1.4 1.8 3.1 -0.7 1.8 1.1 1.5
Medication for hormone replacement therapy 0.1 0.1 0.2 0.4 -0.1 0.2 -0.2
Vitamin and mineral supplements 0.7 1.0 2.8 -1.7 -0.8 0.6 0.2
Supplements: Zinc 1.3 1.4 4.3 0.1 2.1 0.1 1.2
Medication: Co-codamol 0.3 0.4 1.4 -0.1 -0.4 1.2 -0.1
Medication: Metformin 0.8 1.1 3.2 0.5 -1.8 -0.2 -1.0
Diabetes (father) 0.1 0.2 0.5 0.3 -0.7 -0.1 -0.3
Diabetes (mother) 3.7 4.7 11.9 1.7 -2.0 0.1 -3.5
Severe depression (siblings) 0.4 0.5 0.7 -0.8 0.4 -0.8 0.8
Pack years adult smoking proportion 0.3 0.4 1.0 -0.2 0.1 -1.0 -0.7
Impedance of leg (right) 0.1 0.6 1.4 0.1 0.8 1.2 0.6
Leg fat-free mass (left) 1.2 6.3 10.0 1.9 -1.8 -2.9 -3.2
Trunk fat percentage 3.2 12.9 29.5 1.6 -3.4 -2.8 -5.4
Hand grip strength (right) 0.3 0.8 1.0 0.6 1.0 -0.9 1.0
Townsend deprivation index at recruitment 0.1 0.1 0.4 0.3 -0.3 0.6 0.0
Current tobacco smoking 1.4 2.3 4.7 2.2 -1.6 0.9 -1.1
Average weekly fortified wine intake 0.4 0.5 0.7 0.6 0.7 0.9 -0.5
Maternal smoking around birth 1.2 1.7 3.8 0.2 -2.0 -1.4 -1.0
Fed-up feelings 0.2 0.4 0.8 -0.9 0.6 0.1 0.6
Frequency of unenthusiasm / disinterest in last 2 weeks 1.2 1.6 2.0 1.4 -1.0 1.1 -1.4
Relative age voice broke 0.1 0.2 0.6 0.8 -0.2 -0.4 -0.1
Taking other prescription medications 0.7 1.1 4.0 0.4 -0.3 2.0 -0.4
Age when periods started (menarche) 0.7 1.8 4.1 0.6 -2.0 -0.3 -1.6
Bilateral oophorectomy (both ovaries removed) 0.2 0.3 0.7 -0.5 -0.2 0.3 0.8
Heel bone mineral density (BMD) T-score, automated (left) 0.7 1.6 4.0 -1.0 0.9 -2.0 0.8
Tinnitus: Yes, but not now, but have in the past 0.2 0.2 0.6 0.2 0.2 0.8 -0.3
Qualifications: CSEs or equivalent 1.3 1.8 6.9 -0.2 0.5 0.0 2.6
Serious illness, injury or assault to yourself 0.1 0.1 0.2 -0.2 0.1 0.4 -0.2
High blood pressure 0.3 0.8 1.8 -1.4 -1.0 -0.4 -0.1
Hayfever, allergic rhinitis or eczema 0.2 0.4 1.1 1.1 -0.1 -0.1 0.5
Multivitamins +/- minerals 0.7 0.8 1.4 1.0 0.9 -1.2 0.4
Stomach or abdominal pain in last month 2.0 2.5 6.1 -0.8 2.5 0.4 1.8
Supplements: Glucosamine 0.7 0.9 2.0 0.9 0.8 1.4 0.3
Diverticular disease/diverticulitis (self-reported) 0.8 0.9 1.8 -0.8 -1.0 -0.2 1.4
Medication: Atenolol 0.7 0.8 1.5 -1.2 0.9 -0.9 0.5
Medication: Levothyroxine sodium 4.3 7.3 20.5 1.7 -2.2 0.9 -4.5
Sitting height 0.5 3.4 6.3 2.5 -1.1 -1.4 -2.0
Chronic bronchitis/emphysema (father) 1.0 1.1 1.6 0.5 -1.2 -1.3 -1.2
High blood pressure (mother) 0.3 0.4 1.0 0.5 -0.6 0.3 -1.0
Body mass index (BMI) 0.7 2.9 4.7 0.5 -1.5 -2.2 -2.1
Impedance of leg (left) 0.2 1.0 3.3 0.3 0.6 1.8 0.5
Leg predicted mass (left) 1.2 6.5 10.4 2.0 -1.8 -2.9 -3.2
Trunk fat mass 3.1 13.4 29.7 2.0 -3.3 -3.0 -5.5
Waist circumference 1.3 4.7 10.9 0.5 -1.8 -2.1 -3.3
Number of incorrect matches in round 0.1 0.2 0.5 0.3 -0.5 -0.7 0.1
Past tobacco smoking 0.4 0.7 1.6 1.3 -0.8 -0.5 -0.5
Alcohol usually taken with meals 0.4 0.6 1.4 1.2 0.9 -0.3 -0.3
Nervous feelings 0.1 0.2 0.3 0.3 0.5 0.3 0.5
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.4 0.7 0.5 0.7 0.2 0.9
Hearing difficulty/problems with background noise 0.1 0.2 0.6 0.8 0.1 0.2 0.1
Hair/balding pattern: Pattern 2 0.5 0.6 2.0 -1.4 -0.2 -0.6 -0.0
Had menopause 0.7 0.9 1.7 -0.9 -1.3 -0.2 -1.0
Had other major operations 2.2 2.7 7.4 1.2 -1.0 1.0 -2.7
Forced vital capacity (FVC) 0.3 1.2 2.9 -0.4 -0.1 -1.7 1.2
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.8 1.9 0.0 1.1 -1.4 0.1
Ever unenthusiastic/disinterested for a whole week 0.7 0.9 2.7 -1.6 -0.4 -0.7 0.6
Qualifications: None of the above 0.7 1.5 4.8 2.2 0.9 -0.2 -0.4
Financial difficulties in last 2 years 0.3 0.4 1.4 1.2 0.1 0.5 -0.3
Mouth/teeth dental problems 0.2 0.3 0.7 -0.2 0.8 -0.8 -0.2
Heart attack 0.5 0.7 2.3 1.5 -0.0 0.5 -0.3
Allergy 0.3 0.6 1.1 -0.8 -0.8 0.0 -1.0
Pain all over the body in last month 0.2 0.2 0.4 0.4 0.6 -0.3 0.1
Diabetes (self-reported) 0.9 1.4 4.7 -0.2 -2.2 -0.3 -1.0
Hayfever/allergic rhinitis (self-reported) 0.6 0.9 2.0 -0.9 -0.5 -1.4 0.5
Medication: Ramipril 0.3 0.3 0.4 0.3 -0.6 0.7 -0.7
Medication: Simvastatin 1.2 1.7 2.6 -1.6 -1.6 -1.1 -0.6
Fluid intelligence score 0.7 1.4 3.8 -0.1 -0.8 -1.0 -2.0
Illnesses of siblings 0.8 1.2 2.9 -0.8 0.8 -0.6 1.7
Neuroticism score 0.3 0.7 1.3 -1.1 0.9 -0.3 0.7
Weight 1.7 8.2 16.0 2.3 -2.2 -2.6 -4.0
Impedance of arm (right) 0.4 2.1 5.9 1.2 -0.6 0.8 -2.4
Arm fat percentage (right) 2.1 8.2 16.4 1.0 -2.8 -2.7 -4.0
Trunk fat-free mass 0.8 4.5 7.6 2.8 -0.9 -2.2 -2.2
Hip circumference 1.6 6.9 12.2 2.1 -2.1 -2.5 -3.5
Time employed in main current job 1.0 1.2 2.0 -1.4 0.7 0.6 1.4
Alcohol intake versus 10 years previously 0.5 0.7 1.7 0.1 0.5 0.9 1.3
Father’s age at death 0.6 0.7 1.6 -0.4 0.2 -1.3 -1.1
Worrier / anxious feelings 0.5 0.9 2.0 -0.7 0.6 1.4 0.8
Frequency of tiredness / lethargy in last 2 weeks 0.0 0.1 0.1 0.4 -0.2 0.1 0.0
Falls in the last year 1.2 1.6 4.5 1.3 0.0 0.3 -2.1
Hair/balding pattern: Pattern 3 1.1 1.7 2.6 1.2 1.1 1.6 1.3
Number of live births 1.7 2.5 5.2 -0.6 -2.3 -1.9 -0.8
Forced expiratory volume in 1-second (FEV1) 0.4 1.2 3.5 -0.4 -0.9 -1.9 0.6
Pulse rate 0.9 1.5 4.3 2.1 0.3 1.1 0.5
Happiness 0.7 0.8 1.2 1.1 1.1 0.9 0.1
Noisy workplace 0.9 1.1 2.3 -0.3 1.5 0.2 1.5
Qualifications: A levels/AS levels or equivalent 0.8 1.8 4.4 -1.6 -0.2 -2.1 0.3
Serious illness, injury or assault of a close relative in last 2 years 0.7 0.8 3.0 0.0 -0.2 1.7 -0.1
Mouth/teeth dental problems: Dentures 0.5 0.8 2.4 0.9 -0.4 -0.1 -1.5
Asthma 1.2 2.3 4.8 -0.8 2.2 0.2 1.9
Medication: Ibuprofen (e.g. Nurofen) 1.4 1.7 4.6 0.1 1.0 2.1 1.2
Medication: Cholesterol lowering 0.8 1.2 1.9 -0.8 -1.2 -1.4 -1.0
Depression (self-reported) 0.6 0.7 1.5 -1.2 0.8 0.7 0.5
Medication: Lansoprazole 0.2 0.2 0.4 -0.7 0.5 -0.0 0.4
Prospective memory result 2.1 2.6 4.5 1.6 -1.9 -0.0 -2.1
Lung cancer (father) 1.1 1.3 3.4 1.8 1.0 -0.7 0.4
Illnesses of mother 1.1 1.4 3.1 -0.6 1.8 0.2 1.4
Forced expiratory volume in 1-second (FEV1), Best measure 0.6 1.8 6.0 -0.3 -0.6 -2.4 0.8
Pulse wave Arterial Stiffness index 1.0 1.2 2.5 0.5 -1.6 -1.1 -0.9
Impedance of arm (left) 0.3 1.5 4.5 0.5 -0.8 0.9 -2.1
Arm fat mass (right) 2.1 8.5 17.5 1.6 -2.7 -2.6 -4.2
Trunk predicted mass 0.8 4.4 7.5 2.7 -0.9 -2.1 -2.2
Standing height 1.2 11.8 23.1 4.4 -1.9 -1.1 -4.8
Length of working week for main job 0.7 0.8 1.5 0.9 -0.4 0.8 -1.2
Exposure to tobacco smoke at home 0.6 0.6 1.1 0.3 -0.9 -0.7 -1.1
Breastfed as a baby 0.7 0.9 2.7 1.6 0.7 -0.4 0.4
Tense / ‘highly strung’ 0.3 0.5 1.6 -1.2 0.6 -0.2 -0.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.3 0.7 -0.8 0.1 0.3 -0.6
Hair/balding pattern: Pattern 4 0.4 0.9 3.6 -1.9 -0.0 -0.3 0.3
Birth weight of first child 0.7 1.2 4.2 2.0 -0.7 0.4 -0.0
Peak expiratory flow (PEF) 0.7 1.6 6.2 -0.6 -0.2 -2.5 0.2
Pulse wave reflection index 1.3 1.6 3.6 -0.1 -1.1 -1.4 -1.9
Ever highly irritable/argumentative for 2 days 1.4 1.7 2.9 1.7 -1.4 0.4 -1.3
Loud music exposure frequency 2.1 2.3 5.6 1.9 0.0 2.4 -0.0
Qualifications: O levels/GCSEs or equivalent 0.8 1.3 3.3 -1.8 0.1 -0.8 1.1
Mouth/teeth dental problems: Bleeding gums 0.5 0.6 1.3 -1.2 -0.7 0.0 0.8
Blood clot in the leg (DVT) 0.3 0.4 1.2 1.1 -0.1 0.1 -0.7
Medication: Paracetamol 0.3 0.6 1.4 -0.2 -1.2 0.2 -0.9
Headache pain in last month 0.5 0.9 1.6 0.7 1.3 1.1 0.6
Medication for cholesterol, blood pressure or diabetes 0.6 0.9 1.8 0.9 1.3 0.8 0.7
Glaucoma (self-reported) 2.3 2.7 4.7 1.9 -1.1 -1.1 -2.2
Gout (self-reported) 0.5 0.7 1.5 -0.2 -1.1 -1.2 -0.4
Hypothyroidism/myxoedema (self-reported) 5.1 10.0 29.5 1.3 -3.0 0.5 -5.4
Medication: Amlodipine 0.3 0.4 0.9 0.8 0.5 0.0 -1.0
Medication: Ventolin 100micrograms inhaler 1.1 1.4 2.2 -1.3 1.1 0.8 1.5
Birth weight 0.6 1.4 2.0 1.1 -1.4 -1.3 -0.9
Chronic bronchitis/emphysema (mother) 0.1 0.2 0.6 -0.8 -0.3 0.2 -0.0
High blood pressure (siblings) 2.1 3.0 5.4 2.2 -0.9 0.9 -2.3
Forced vital capacity (FVC), Best measure 0.3 1.3 4.4 -0.1 -0.2 -2.1 0.8
Body fat percentage 2.5 10.0 22.3 1.5 -2.9 -2.7 -4.7
Leg fat percentage (right) 1.1 3.9 7.7 0.9 -1.3 -2.3 -2.8
Arm fat-free mass (right) 0.6 3.2 4.5 1.8 -1.0 -2.1 -2.0
Exposure to tobacco smoke outside home 0.5 0.7 1.8 1.3 -0.0 0.1 -1.0
Comparative body size at age 10 0.8 2.2 4.3 -1.5 1.5 0.2 2.1
Number of full brothers 0.4 0.5 0.8 0.1 -0.8 -0.8 -0.9
Worry too long after embarrassment 0.1 0.2 0.7 -0.3 -0.8 0.2 -0.3
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.2 0.6 -0.8 0.1 0.5 -0.2
Wheeze or whistling in the chest in last year 0.8 1.4 2.9 0.0 1.7 1.5 0.7
Number of children fathered 1.3 1.5 3.3 0.5 -0.9 1.3 -1.8
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.5 1.4 -0.5 0.5 1.2 0.1
Age at first live birth 2.1 3.7 5.1 -1.9 2.3 1.6 1.9
Pulse wave peak to peak time 0.6 0.8 1.8 -0.3 1.4 0.9 0.5
Health satisfaction 1.5 1.9 4.8 2.2 -0.9 0.4 -1.4
Shortness of breath walking on level ground 0.4 0.4 1.5 0.1 -0.5 0.2 -1.2
Qualifications: College or University degree 0.2 0.7 2.1 -1.4 0.7 -0.2 -0.5
Eye problems/disorders: None of the above 0.8 1.0 2.1 -0.5 1.1 0.4 1.5
Mouth/teeth dental problems: Loose teeth 0.5 0.5 1.5 1.2 0.2 0.6 -0.5
Emphysema/chronic bronchitis 1.0 1.1 3.0 1.1 0.2 1.7 0.0
Medication for pain relief, constipation, heartburn 0.1 0.2 0.5 -0.3 -0.0 -0.7 0.3
Neck or shoulder pain in last month 1.3 1.8 3.6 -1.5 1.0 0.4 1.9
Medication: Blood pressure 0.3 0.5 1.0 -1.0 -0.4 -0.7 -0.5
Angina (self-reported) 1.4 1.9 3.3 -0.5 1.8 1.1 1.6
Migraine (self-reported) 0.5 0.6 1.6 -0.2 0.7 0.2 1.3
Medication: Ibuprofen 1.2 1.4 3.5 0.6 1.1 1.9 0.7
Medication: Allopurinol 1.0 1.4 3.6 -1.9 0.0 -1.1 0.8
Medication: Omeprazole 0.5 0.6 1.5 0.8 1.2 0.1 0.7
Medication: Seretide 50 evohaler 0.3 0.3 1.1 -1.0 0.1 -0.2 0.2
Mean time to correctly identify matches 0.2 0.4 1.1 0.4 0.1 1.1 0.4
Heart disease (mother) 4.0 4.9 10.0 1.5 -3.2 0.2 -2.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.3 0.3 0.7 -0.1 0.4 -0.9 0.6
Whole body fat mass 2.4 10.2 21.3 1.9 -2.7 -3.0 -4.6
Leg fat mass (right) 1.6 6.2 11.9 1.4 -1.9 -2.7 -3.5
Arm predicted mass (right) 0.8 3.9 5.2 2.1 -1.1 -2.3 -2.1
Pulse rate, automated reading 0.1 0.2 0.6 0.0 -0.8 0.3 0.3
Alcohol intake frequency. 0.2 0.6 1.2 0.4 -1.1 -1.0 -0.2
Comparative height size at age 10 0.7 3.7 7.3 1.8 -1.9 -0.8 -2.7
Number of full sisters 0.9 1.1 2.2 1.5 -1.1 0.3 -0.9
Suffer from ‘nerves’ 0.6 0.9 1.8 -1.3 0.9 0.1 1.0
Overall health rating 0.2 0.5 1.0 1.0 -0.6 0.5 -0.6
Chest pain or discomfort 0.2 0.3 0.5 0.7 0.6 -0.3 0.4
Had major operations 0.5 0.6 1.5 1.2 0.1 -0.3 -0.8
Age at last live birth 0.8 1.1 3.7 -0.6 1.9 -0.5 0.5
Family relationship satisfaction 0.4 0.6 1.3 0.1 0.4 1.1 0.8
Leg pain on walking 1.7 2.1 4.2 2.0 -1.3 -0.1 -1.6
Qualifications: NVQ or HND or HNC or equivalent 0.6 0.8 2.4 -0.1 -1.5 0.2 -0.8
Commuting to job workplace: Car/motor vehicle 0.4 0.4 1.6 0.1 -1.3 0.2 0.1
Illness, injury, bereavement, stress in last 2 years 0.6 0.7 1.1 -0.7 -1.0 -1.0 -0.4
Medication: Aspirin 0.2 0.3 0.6 -0.1 0.3 0.7 -0.7
Supplements: Vitamin C 0.3 0.3 0.5 0.4 -0.1 -0.7 -0.7
Knee pain experienced in last month 1.2 1.9 3.6 0.8 -1.9 1.3 -1.3
Hypertension (Self-reported) 0.2 0.4 0.9 -1.0 -0.7 0.5 0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.6 1.9 -0.2 0.4 0.6 1.4
Illnesses of father: Heart disease 0.6 0.8 2.2 -1.1 -1.5 0.1 0.3
Illnesses of siblings: Diabetes 1.2 1.5 3.4 0.6 -1.5 0.2 -1.8
Smoking status: Previous 0.3 0.4 1.7 -1.3 0.3 0.1 -0.1
Forced expiratory volume in 1-second (FEV1), predicted 1.2 2.4 5.3 2.3 -0.1 -1.7 -1.3
Whole body fat-free mass 0.9 5.0 6.8 2.4 -1.3 -2.4 -2.6
Leg fat-free mass (right) 1.0 5.4 9.0 1.9 -1.7 -2.4 -3.0
Arm fat percentage (left) 2.0 7.8 15.7 0.9 -2.8 -2.7 -4.0
Average weekly red wine intake 0.3 0.4 1.1 -0.4 0.5 -1.0 -0.1
Handedness (chirality/laterality): Left-handed 0.3 0.4 0.7 0.9 -0.7 -0.6 0.2
Mood swings 0.2 0.4 0.5 -0.4 0.7 -0.6 0.7
Loneliness, isolation 0.8 1.1 3.7 0.6 1.9 -0.4 -0.1
Long-standing illness, disability or infirmity 0.6 0.9 2.5 0.9 -0.4 0.4 -1.6
Ever had bowel cancer screening 0.3 0.3 0.7 0.4 0.8 0.3 0.5
Diabetes diagnosed by doctor 1.4 2.3 7.6 -0.3 -2.8 -0.5 -1.2
Ever had stillbirth, spontaneous miscarriage or termination 0.9 0.9 1.9 0.2 1.4 0.5 1.2
Friendships satisfaction 0.4 0.5 1.1 1.1 0.9 0.3 -0.3
Qualifications: nursing, teaching 0.9 1.4 3.0 -1.7 -0.7 -0.6 -1.3
Commuting to job workplace: Walk 1.2 1.3 3.6 0.4 -1.1 -0.3 -1.9
Eye problems/disorders: Cataract 0.3 0.4 0.7 0.5 0.8 -0.2 -0.8
Mouth/teeth dental problems: Mouth ulcers 1.2 1.9 4.5 -1.0 0.8 1.2 2.1
Medication for cholesterol 0.3 0.5 0.9 0.8 0.4 -0.9 0.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.6 0.7 1.4 0.2 -1.2 0.5 -1.1
Back pain experienced in last month 1.6 2.4 6.5 -0.2 -1.0 2.5 1.4
Mineral and other dietary supplements 0.5 0.6 1.0 -1.0 -0.5 0.6 1.0
Breast cancer (self-reported) 1.5 1.8 4.2 -2.0 -1.4 -0.4 -1.0
Asthma (self-reported) 1.3 2.7 6.2 -0.5 2.5 0.3 2.0
Osteoporosis (self-reported) 1.5 1.9 3.4 0.8 -1.8 -0.6 -1.8
Osteoarthritis (self-reported) 0.2 0.3 0.7 0.4 0.4 0.9 -0.1
Medication: Aspirin 0.2 0.2 0.8 0.0 0.1 0.3 -0.9
Medication: Gliclazide 3.6 4.1 8.7 -0.3 -2.6 -0.8 -3.0
Illnesses of father: None of the above (group 1) 1.3 1.7 4.7 0.4 2.2 0.7 1.1
Smoking status: Current 1.0 1.6 4.0 2.0 -0.9 1.2 -0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.7 1.4 2.8 -0.3 0.5 -1.7 1.5
Whole body water mass 0.8 4.8 6.8 2.3 -1.2 -2.4 -2.6
Leg predicted mass (right) 1.1 5.7 9.9 1.9 -1.8 -2.5 -3.1
Arm fat mass (left) 1.9 7.8 15.3 1.4 -2.6 -2.7 -3.9
Number of self-reported non-cancer illnesses 0.4 0.6 1.2 0.5 0.8 1.1 -0.5
Average weekly champagne plus white wine intake 0.2 0.3 0.5 0.4 0.6 -0.2 0.7
Miserableness 0.1 0.2 0.7 -0.2 0.8 -0.2 0.3
Guilty feelings 0.3 0.5 1.2 -0.2 -0.2 -0.9 1.1
Wears glasses or contact lenses 1.8 2.1 5.2 0.4 -1.7 -0.2 -2.3
Ever taken oral contraceptive pill 0.5 0.5 1.6 1.3 -0.1 0.7 -0.3
Hearing aid user 0.4 0.4 1.3 -0.0 -1.1 -0.2 -0.6
Mother’s age at death 0.1 0.1 0.4 0.6 -0.1 0.3 -0.3
Financial situation satisfaction 0.2 0.3 0.9 0.1 0.9 0.3 0.4
Tinnitus: Yes, now most or all of the time 1.5 1.8 3.3 -1.4 1.8 -0.6 1.2
Commuting to job workplace: Public transport 0.7 0.8 1.5 1.0 0.1 -1.2 -0.8
Eye problems/disorders: Glaucoma 4.3 5.1 8.5 1.8 -2.2 -2.0 -2.9
Medication: Blood pressure 0.2 0.3 0.8 -0.6 0.0 0.9 -0.0
Pain type(s) experienced in last month: Hip pain 0.5 0.7 1.2 0.6 1.1 0.6 0.9
Supplements: Fish oil (including cod liver oil) 0.8 1.1 2.0 1.2 1.4 -0.2 -0.9
High cholesterol (Self-reported) 0.4 0.8 2.0 -0.6 -1.4 -0.3 -0.8
Medication: Bendroflumethiazide 0.3 0.4 1.3 -1.1 -0.4 0.3 0.1
Medication: Paracetamol 0.2 0.2 0.5 0.1 -0.7 -0.1 -0.6
Medication: Lisinopril 0.5 0.6 1.5 -0.8 0.4 -1.2 0.5
Medication: Atorvastatin 0.5 0.6 1.5 0.7 -0.2 0.5 -1.2
Illnesses of father: High blood pressure 0.7 0.9 1.9 -0.5 -1.0 1.4 -0.6
Alcohol drinker status: Never 2.7 3.2 8.1 0.7 -1.2 -2.9 -1.7
Ever smoked 0.4 0.7 1.3 -1.2 0.7 0.3 0.8
Basal metabolic rate 1.0 5.6 8.6 2.3 -1.5 -2.5 -2.9
Leg fat percentage (left) 1.1 3.9 8.4 1.0 -1.6 -1.9 -2.9
Arm fat-free mass (left) 0.9 4.3 6.7 2.6 -1.1 -1.8 -2.5
Number of operations (self-reported) 1.1 1.7 3.9 1.1 -0.8 1.0 -2.0
Average weekly beer plus cider intake 0.6 0.8 1.9 -0.5 -0.8 -1.4 0.7
Irritability 0.8 1.4 3.8 0.3 1.9 1.1 0.8
Risk taking 1.9 2.8 5.8 -0.1 2.0 1.1 2.4
Ever had prostate specific antigen (PSA) test 0.9 1.0 2.1 1.4 -0.2 -0.3 -1.5
Fractured/broken bones in last 5 years 0.6 0.8 1.7 -1.3 0.6 0.4 -1.1
Age started oral contraceptive pill 0.3 0.4 1.1 0.2 0.2 -0.5 -1.1
Diastolic blood pressure, automated reading 0.4 1.2 2.0 -1.4 0.7 -0.5 1.4
Ever depressed for a whole week 1.5 1.9 2.5 -1.6 -1.6 -1.4 0.9
Unable to work because of sickness or disability 2.6 3.4 8.1 2.0 0.7 2.9 -1.0
Commuting to job workplace: Cycle 0.9 1.1 2.9 0.6 1.7 0.8 0.8
Myopia 0.7 1.1 3.6 -0.1 -0.7 1.9 -0.3
Vascular/heart problems diagnosed by doctor 0.2 0.5 1.6 1.2 0.3 -0.2 -0.4
Cholesterol lowering medication 0.4 0.6 1.2 -0.7 -0.8 1.1 -0.1
Medication: Omeprazole (e.g. Zanprol) 0.7 0.9 1.4 1.1 1.2 0.2 0.8
Pain experienced in last month 0.5 0.8 2.4 -0.7 0.5 -1.6 0.2
Supplements: Calcium 0.1 0.1 0.3 0.2 -0.4 0.2 0.6
Basal cell carcinoma (self-reported) 1.6 1.9 4.7 0.3 -1.4 -0.9 -2.2
Heart attack/myocardial infarction (self-reported) 0.5 0.6 2.2 1.5 -0.1 0.5 -0.3
Deep venous thrombosis (DVT) (self-reported) 0.3 0.3 0.8 0.9 -0.1 0.2 -0.7
Heart disease (siblings) 0.5 0.6 1.4 -0.6 -1.2 -0.6 -0.6
Alcohol drinker status: Previous 0.5 0.6 1.2 0.3 -1.1 -0.3 -1.0
Pack years of smoking 0.5 0.7 1.9 -0.4 0.1 -1.4 -0.8
Impedance of whole body 0.2 1.1 2.0 0.7 -0.2 1.4 -1.3
Leg fat mass (left) 1.7 6.5 12.9 1.5 -2.1 -2.6 -3.6
Arm predicted mass (left) 0.9 4.5 7.2 2.7 -1.0 -1.8 -2.5