[Hub]/) : Traits : Hayfever/allergic rhinitis (self-reported) : ← →

chr2:241,978,472-243,048,760

Best TWAS P=2.39e-12 · Best GWAS P=3.9e-11 conditioned to 0.662

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	D2HGDH	0.29	0.12	enet	6	0.14	1.2e-16	-6.6	7.0	2.4e-12	-0.92	0.00	1.00	TRUE
2	GTEx	Adipose Subcutaneous	D2HGDH	0.43	0.28	lasso	7	0.28	3.0e-23	5.7	6.0	1.7e-09	-0.80	0.17	0.83	FALSE
3	GTEx	Adipose Subcutaneous	AC114730.7	0.42	0.24	lasso	6	0.22	4.9e-18	5.7	6.0	2.2e-09	-0.81	0.17	0.83	FALSE
4	GTEx	Adipose Visceral Omentum	D2HGDH	0.52	0.26	lasso	4	0.27	2.3e-14	5.7	5.5	4.0e-08	-0.70	0.19	0.81	FALSE
5	GTEx	Adipose Visceral Omentum	AC114730.7	0.43	0.22	lasso	3	0.23	5.0e-12	5.7	5.6	1.7e-08	-0.73	0.18	0.82	FALSE
6	GTEx	Adrenal Gland	D2HGDH	0.39	0.32	lasso	1	0.31	1.3e-11	5.7	5.7	9.1e-09	-0.75	0.13	0.87	FALSE
7	GTEx	Adrenal Gland	AC114730.7	0.29	0.27	lasso	1	0.23	6.8e-09	5.7	5.7	9.1e-09	-0.75	0.16	0.84	FALSE
8	GTEx	Artery Aorta	D2HGDH	0.23	0.15	lasso	2	0.15	1.1e-08	5.7	5.5	4.8e-08	-0.75	0.11	0.89	FALSE
9	GTEx	Artery Tibial	D2HGDH	0.50	0.32	lasso	7	0.31	7.7e-25	5.7	5.8	6.7e-09	-0.75	0.18	0.82	FALSE
10	GTEx	Artery Tibial	AC114730.8	0.15	0.12	lasso	1	0.12	2.6e-09	5.7	5.7	9.1e-09	-0.75	0.18	0.82	FALSE
11	GTEx	Artery Tibial	AC114730.7	0.40	0.27	lasso	5	0.26	1.7e-20	5.7	5.8	7.8e-09	-0.75	0.18	0.82	FALSE
12	GTEx	Brain Cerebellar Hemisphere	AC114730.7	0.54	0.37	lasso	2	0.36	3.5e-10	5.7	6.1	9.3e-10	-0.85	0.10	0.90	FALSE
13	GTEx	Brain Cerebellum	D2HGDH	0.55	0.32	lasso	5	0.29	2.9e-09	5.7	5.9	3.5e-09	-0.77	0.16	0.84	FALSE
14	GTEx	Brain Cerebellum	AC114730.7	0.58	0.40	lasso	5	0.42	6.9e-14	5.7	5.8	5.5e-09	-0.77	0.20	0.80	FALSE
15	GTEx	Brain Frontal Cortex BA9	D2HGDH	0.42	0.23	lasso	4	0.26	1.7e-07	5.7	6.4	1.8e-10	-0.90	0.01	0.98	FALSE
16	GTEx	Brain Frontal Cortex BA9	AC114730.7	0.36	0.22	lasso	4	0.19	1.2e-05	5.7	5.7	9.7e-09	-0.75	0.13	0.73	FALSE
17	GTEx	Brain Hypothalamus	D2HGDH	0.64	0.24	lasso	10	0.16	1.1e-04	5.9	5.7	1.1e-08	-0.74	0.06	0.91	FALSE
18	GTEx	Brain Hypothalamus	AC114730.7	0.55	0.21	enet	17	0.22	8.6e-06	5.9	5.4	5.4e-08	-0.73	0.08	0.73	FALSE
19	GTEx	Brain Nucleus accumbens basal ganglia	D2HGDH	0.54	0.43	lasso	1	0.41	3.3e-12	5.7	5.7	9.1e-09	-0.75	0.17	0.83	FALSE
20	GTEx	Brain Nucleus accumbens basal ganglia	AC114730.7	0.42	0.25	lasso	4	0.26	1.2e-07	5.7	5.8	7.6e-09	-0.76	0.13	0.83	FALSE
21	GTEx	Brain Putamen basal ganglia	D2HGDH	0.46	0.20	enet	15	0.30	6.7e-08	5.7	5.7	1.5e-08	-0.73	0.01	0.95	FALSE
22	GTEx	Brain Putamen basal ganglia	AC114730.7	0.39	0.24	enet	24	0.26	6.4e-07	5.7	5.4	7.4e-08	-0.62	0.03	0.88	FALSE
23	GTEx	Breast Mammary Tissue	D2HGDH	0.31	0.19	enet	5	0.19	2.8e-10	5.7	5.7	1.3e-08	-0.76	0.20	0.80	FALSE
24	GTEx	Breast Mammary Tissue	AC114730.7	0.27	0.18	enet	8	0.18	1.9e-09	5.7	5.8	6.8e-09	-0.75	0.19	0.81	FALSE
25	GTEx	Breast Mammary Tissue (Male)	D2HGDH	0.43	0.24	lasso	6	0.20	1.9e-05	5.7	6.1	1.4e-09	-0.83	0.02	0.90	FALSE
26	GTEx	Breast Mammary Tissue (Male)	AC114730.7	0.30	0.17	lasso	3	0.20	2.8e-05	5.7	6.4	1.7e-10	-0.88	0.01	0.92	FALSE
27	GTEx	Cells EBV-transformed lymphocytes	D2HGDH	0.23	0.26	lasso	1	0.24	1.9e-08	5.7	5.7	9.1e-09	-0.75	0.12	0.85	FALSE
28	GTEx	Cells Transformed fibroblasts	D2HGDH	0.44	0.27	lasso	11	0.30	1.2e-22	5.7	6.4	1.9e-10	-0.86	0.18	0.82	FALSE
29	GTEx	Cells Transformed fibroblasts	AC114730.8	0.32	0.12	lasso	4	0.16	4.5e-12	5.9	6.7	2.2e-11	-0.89	0.01	0.99	FALSE
30	GTEx	Cells Transformed fibroblasts	AC114730.7	0.27	0.17	lasso	4	0.16	3.6e-12	5.7	5.7	1.4e-08	-0.77	0.23	0.77	FALSE
31	GTEx	Colon Transverse	D2HGDH	0.48	0.27	lasso	4	0.25	2.8e-12	5.9	6.4	1.3e-10	-0.80	0.08	0.92	FALSE
32	GTEx	Colon Transverse	AC114730.7	0.53	0.26	enet	26	0.24	1.1e-11	5.9	5.9	3.6e-09	-0.71	0.09	0.91	FALSE
33	GTEx	Esophagus Mucosa	D2HGDH	0.34	0.21	enet	7	0.22	8.7e-15	5.9	5.9	3.5e-09	-0.82	0.09	0.91	FALSE
34	GTEx	Esophagus Mucosa	AC114730.7	0.31	0.18	enet	6	0.18	2.3e-12	5.7	6.1	1.1e-09	-0.81	0.09	0.91	FALSE
35	GTEx	Esophagus Muscularis	D2HGDH	0.21	0.19	lasso	2	0.18	7.0e-11	5.7	5.8	8.6e-09	-0.75	0.17	0.83	FALSE
36	GTEx	Heart Left Ventricle	D2HGDH	0.23	0.12	enet	14	0.17	3.7e-09	5.7	6.3	2.3e-10	-0.83	0.02	0.98	FALSE
37	GTEx	Muscle Skeletal	D2HGDH	0.26	0.11	lasso	2	0.14	3.0e-13	-6.6	6.8	1.3e-11	-0.94	0.00	1.00	FALSE
38	GTEx	Muscle Skeletal	AC114730.7	0.17	0.09	lasso	2	0.09	9.5e-09	5.9	5.9	2.8e-09	-0.75	0.10	0.90	FALSE
39	GTEx	Nerve Tibial	AC114730.8	0.26	0.10	lasso	4	0.07	1.0e-05	5.7	5.8	8.6e-09	-0.76	0.12	0.87	FALSE
40	GTEx	Pancreas	D2HGDH	0.48	0.32	lasso	11	0.31	1.4e-13	5.7	6.0	1.6e-09	-0.74	0.16	0.84	FALSE
41	GTEx	Pancreas	AC114730.8	0.20	0.15	lasso	3	0.14	1.7e-06	5.7	5.9	2.8e-09	-0.73	0.05	0.86	FALSE
42	GTEx	Pancreas	AC114730.7	0.36	0.25	lasso	4	0.25	6.4e-11	5.7	5.8	7.3e-09	-0.73	0.17	0.83	FALSE
43	GTEx	Pituitary	D2HGDH	0.42	0.30	enet	27	0.28	8.7e-08	5.7	5.3	9.1e-08	-0.66	0.12	0.82	FALSE
44	GTEx	Skin Not Sun Exposed Suprapubic	D2HGDH	0.37	0.17	lasso	2	0.18	6.1e-10	5.7	5.7	9.2e-09	-0.76	0.17	0.83	FALSE
45	GTEx	Skin Not Sun Exposed Suprapubic	AC114730.7	0.35	0.19	lasso	2	0.18	5.3e-10	5.7	5.7	9.1e-09	-0.75	0.18	0.82	FALSE
46	GTEx	Skin Sun Exposed Lower leg	D2HGDH	0.38	0.25	lasso	6	0.25	1.3e-20	5.7	5.7	1.2e-08	-0.78	0.19	0.81	FALSE
47	GTEx	Skin Sun Exposed Lower leg	AC114730.7	0.35	0.28	lasso	3	0.28	6.2e-23	5.7	5.4	5.2e-08	-0.75	0.18	0.82	FALSE
48	GTEx	Spleen	AC114730.7	0.31	0.22	lasso	3	0.20	6.3e-06	5.7	5.7	9.7e-09	-0.76	0.10	0.68	FALSE
49	GTEx	Testis	D2HGDH	0.64	0.39	enet	20	0.42	4.5e-20	5.7	5.3	1.3e-07	-0.72	0.17	0.83	FALSE
50	GTEx	Testis	AC114730.7	0.53	0.30	enet	17	0.29	3.3e-13	5.7	5.3	1.4e-07	-0.71	0.17	0.83	FALSE
51	GTEx	Thyroid	D2HGDH	0.42	0.30	lasso	5	0.30	2.3e-23	5.7	5.7	1.4e-08	-0.75	0.18	0.82	FALSE
52	GTEx	Thyroid	AC114730.8	0.17	0.10	lasso	2	0.10	2.6e-08	5.7	5.8	7.0e-09	-0.75	0.19	0.81	FALSE
53	GTEx	Thyroid	AC114730.7	0.35	0.26	lasso	3	0.26	5.0e-20	5.7	5.7	1.2e-08	-0.75	0.18	0.82	FALSE
54	GTEx	Uterus	AC093642.3	0.35	-0.01	enet	25	0.07	1.8e-02	-2.0	-5.2	2.3e-07	0.46	0.02	0.27	FALSE
55	GTEx	Whole Blood	D2HGDH	0.12	0.08	lasso	3	0.08	5.7e-08	5.9	6.3	3.3e-10	-0.81	0.04	0.96	FALSE
56	GTEx	Whole Blood	AC114730.7	0.11	0.08	lasso	3	0.08	4.1e-08	5.7	6.1	1.1e-09	-0.80	0.06	0.94	FALSE
57	ROSMAP	Brain Pre-frontal Cortex	GAL3ST2	0.10	0.09	lasso	1	0.08	5.8e-11	5.9	-5.9	3.1e-09	0.73	0.08	0.92	FALSE
58	ROSMAP	Brain Pre-frontal Cortex	D2HGDH	0.44	0.33	lasso	6	0.35	2.1e-46	5.9	6.2	5.3e-10	-0.74	0.07	0.93	FALSE
59	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	D2HGDH	0.06	0.02	blup	28	0.04	1.3e-05	-6.6	5.4	6.3e-08	-0.86	0.00	1.00	FALSE
60	The Cancer Genome Atlas	Prostate Adenocarcinoma	GAL3ST2	0.03	0.03	enet	3	0.03	8.9e-04	5.9	-5.9	3.7e-09	0.76	0.02	0.78	FALSE