Best TWAS P=1.34e-16 · Best GWAS P=1.43e-17 conditioned to 0.02
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | TLR1 | 0.08 | 0.07 | lasso | 2 | 0.07 | 1.3e-08 | -7.7 | -8.0 | 1.2e-15 | 0.89 | 0.15 | 0.85 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | TLR6 | 0.28 | 0.19 | lasso | 5 | 0.17 | 1.7e-12 | -7.6 | 7.5 | 5.1e-14 | -0.77 | 0.68 | 0.32 | FALSE |
| 3 | GTEx | Esophagus Mucosa | TLR1 | 0.20 | 0.02 | lasso | 6 | 0.04 | 9.8e-04 | -7.6 | 7.5 | 5.5e-14 | -0.87 | 0.06 | 0.93 | FALSE |
| 4 | GTEx | Esophagus Mucosa | FAM114A1 | 0.14 | 0.03 | lasso | 11 | 0.03 | 6.6e-03 | 3.9 | -5.1 | 3.0e-07 | 0.51 | 0.52 | 0.36 | FALSE |
| 5 | GTEx | Esophagus Muscularis | TLR1 | 0.21 | 0.02 | enet | 46 | 0.06 | 2.3e-04 | -7.1 | 6.1 | 1.0e-09 | -0.54 | 0.07 | 0.80 | FALSE |
| 6 | GTEx | Skin Not Sun Exposed Suprapubic | TLR6 | 0.29 | 0.03 | lasso | 11 | 0.08 | 4.8e-05 | 3.1 | 6.7 | 1.8e-11 | -0.66 | 0.44 | 0.47 | FALSE |
| 7 | GTEx | Testis | FAM114A1 | 0.37 | 0.20 | lasso | 7 | 0.20 | 2.2e-09 | -7.9 | -7.0 | 2.6e-12 | 0.80 | 0.14 | 0.86 | FALSE |
| 8 | ROSMAP | Brain Pre-frontal Cortex | TLR1 | 0.08 | 0.02 | blup | 514 | 0.03 | 2.3e-05 | -7.5 | -6.8 | 7.8e-12 | 0.68 | 0.02 | 0.98 | FALSE |
| 9 | YFS | Blood | TLR1 | 0.08 | 0.05 | bslmm | 525 | 0.07 | 1.2e-20 | -8.0 | 6.2 | 6.0e-10 | -0.72 | 0.05 | 0.95 | FALSE |
| 10 | YFS | Blood | TLR6 | 0.05 | 0.04 | bslmm | 505 | 0.06 | 1.3e-18 | -7.7 | 7.1 | 1.7e-12 | -0.82 | 0.43 | 0.57 | FALSE |
| 11 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | TLR6 | 0.03 | 0.02 | lasso | 2 | 0.01 | 3.5e-02 | -7.6 | 7.6 | 2.2e-14 | -0.76 | 0.05 | 0.11 | FALSE |
| 12 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | TLR1 | 0.04 | 0.03 | lasso | 4 | 0.03 | 8.2e-05 | -7.9 | 8.3 | 1.3e-16 | -0.92 | 0.01 | 0.99 | TRUE |
| 13 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | TLR10 | 0.09 | 0.06 | lasso | 2 | 0.06 | 2.3e-04 | -6.0 | 6.1 | 1.3e-09 | -0.56 | 0.16 | 0.06 | FALSE |
| 14 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | TLR1 | 0.14 | 0.07 | enet | 12 | 0.10 | 1.7e-05 | -7.5 | 6.8 | 7.9e-12 | -0.79 | 0.30 | 0.63 | FALSE |
| 15 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | TLR1 | 0.03 | 0.03 | enet | 23 | 0.03 | 1.5e-04 | -7.9 | 6.0 | 1.5e-09 | -0.65 | 0.04 | 0.88 | FALSE |
| 16 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | TLR1 | 0.13 | 0.13 | enet | 3 | 0.08 | 2.6e-03 | -3.8 | 5.6 | 1.7e-08 | -0.78 | 0.01 | 0.76 | FALSE |