Hub : Traits :

Hayfever/allergic rhinitis (self-reported)

141 significantly associated models · 34 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	1	166702558	168182443	1	1	8.4e-09	3.2e-09	1.5e-01	94	CD247
2	2	102118712	103686111	4	1	2.6e-21	3.0e-17	5.3e-02	95	IL1RL1
3	2	197745121	200117777	2	1	2.2e-07	1.0e-07	1.0e+00	100	PLCL1
4	2	241978472	243048760	5	1	2.4e-12	3.9e-11	6.6e-01	100	D2HGDH
5	4	38097478	39643536	4	1	1.3e-16	1.4e-17	2.0e-02	93	TLR1
6	4	122377715	123976639	1	1	3.6e-11	2.4e-10	5.1e-06	48	KIAA1109
7	5	35608310	36124514	1	1	2.0e-13	9.3e-14	1.0e+00	100	IL7R
8	5	109381583	111527482	4	8	3.2e-15	8.3e-18	NaN	NaN	CAMK4 SLC25A46 TSLP
9	9	5317534	7345304	2	2	2.0e-08	2.5e-13	1.9e-07	49	GLDC RANBP6
10	11	75678647	77069746	1	1	2.2e-13	3.6e-18	1.2e-07	63	LRRC32
11	15	67111296	67736023	1	1	1.1e-08	4.1e-11	8.9e-04	75	SMAD3
12	15	90233553	91744509	1	1	4.1e-10	4.2e-07	9.2e-01	100	IQGAP1
13	17	37363793	38783469	4	1	1.7e-09	2.3e-09	5.8e-02	90	ORMDL3
14	21	44831798	45361095	1	1	4.5e-08	1.0e-05	2.4e-01	93	RRP1B

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr	corr P	genes
Allergy or Eczema	57.39	17	16	35.6	0.98	4.8e-16	CAMK4 CD247 D2HGDH GLDC IL1RL1 IL7R IQGAP1 KIAA1109 LRRC32 ORMDL3 PLCL1 RANBP6 RRP1B SLC25A46 SMAD3 TLR1 TSLP
Allergy	56.65	17	16	35.6	-0.99	1.4e-17	CAMK4 CD247 D2HGDH GLDC IL1RL1 IL7R IQGAP1 KIAA1109 LRRC32 ORMDL3 PLCL1 RANBP6 RRP1B SLC25A46 SMAD3 TLR1 TSLP
Hayfever, allergic rhinitis or eczema	53.26	17	16	35.6	0.99	5.4e-17	CAMK4 CD247 D2HGDH GLDC IL1RL1 IL7R IQGAP1 KIAA1109 LRRC32 ORMDL3 PLCL1 RANBP6 RRP1B SLC25A46 SMAD3 TLR1 TSLP
Asthma	37.79	15	14	31.1	0.97	4.4e-12	CAMK4 CD247 D2HGDH GLDC IL1RL1 IL7R KIAA1109 LRRC32 ORMDL3 PLCL1 RANBP6 SLC25A46 SMAD3 TLR1 TSLP
Asthma (self-reported)	36.65	15	14	31.1	0.96	1.3e-11	CAMK4 CD247 D2HGDH GLDC IL1RL1 IL7R KIAA1109 LRRC32 ORMDL3 PLCL1 RANBP6 SLC25A46 SMAD3 TLR1 TSLP
Respiratory disease	34.97	14	14	31.1	0.95	2.6e-10	CAMK4 CD247 D2HGDH GLDC IL1RL1 IL7R KIAA1109 LRRC32 ORMDL3 RANBP6 SLC25A46 SMAD3 TLR1 TSLP
Blood Eosinophil Count	30.49	13	12	26.7	0.92	9.4e-08	CAMK4 CD247 D2HGDH GLDC IL1RL1 IL7R KIAA1109 LRRC32 ORMDL3 RANBP6 SLC25A46 SMAD3 TSLP
Medication: Ventolin 100micrograms inhaler	15.95	12	6	13.3	0.97	7.4e-08	CD247 D2HGDH GLDC IL1RL1 KIAA1109 LRRC32 ORMDL3 RANBP6 SLC25A46 SMAD3 TLR1 TSLP
Wheeze or whistling in the chest in last year	15.27	13	8	17.8	0.96	8.3e-09	CAMK4 CD247 D2HGDH GLDC IL1RL1 KIAA1109 LRRC32 ORMDL3 RANBP6 SLC25A46 SMAD3 TLR1 TSLP
Medication: Seretide 50 evohaler	7.50	4	1	2.2	0.99	1.3e-02	D2HGDH IL1RL1 KIAA1109 SMAD3
Blood White Count	4.81	6	1	2.2	0.47	3.4e-01	IL1RL1 IL7R IQGAP1 ORMDL3 PLCL1 TLR1
Number of self-reported non-cancer illnesses	4.45	5	1	2.2	0.99	1.2e-03	D2HGDH IL1RL1 KIAA1109 LRRC32 ORMDL3
Taking other prescription medications	4.41	3	0	0.0	0.00	1.0e+00	D2HGDH IL1RL1 ORMDL3
Crohns Disease (2017)	4.32	5	2	4.4	0.73	1.6e-01	KIAA1109 LRRC32 ORMDL3 PLCL1 SMAD3
Irritable Bowel Disease (IBD)	4.30	4	4	8.9	0.73	2.7e-01	KIAA1109 LRRC32 ORMDL3 SMAD3
Crohns Disease (2012)	3.60	3	1	2.2	0.00	1.0e+00	LRRC32 PLCL1 SMAD3
Primary Biliary Cirrhosis	3.59	2	2	4.4	0.00	1.0e+00	IL7R ORMDL3
Ulcerative Colitis (UC)	2.94	4	1	2.2	0.71	2.9e-01	KIAA1109 LRRC32 ORMDL3 SMAD3
Ulcerative Colitis	2.91	2	1	2.2	0.00	1.0e+00	KIAA1109 SMAD3
Hypothyroidism (self reported)	2.71	4	2	4.4	-0.23	7.7e-01	CD247 IL7R KIAA1109 TLR1
Chronotype (morning person)	2.53	4	1	2.2	-0.97	3.0e-02	CAMK4 KIAA1109 PLCL1 TSLP
Hypothyroidism/myxoedema (self-reported)	2.38	3	0	0.0	0.00	1.0e+00	CD247 IL7R KIAA1109
Lupus	2.26	1	1	2.2	0.00	1.0e+00	ORMDL3
Lung FEV1/FVC ratio	2.26	6	3	6.7	-0.99	1.5e-04	D2HGDH GLDC IL1RL1 IL7R ORMDL3 SMAD3
Impedance of arm (right)	2.17	3	2	4.4	0.00	1.0e+00	LRRC32 ORMDL3 PLCL1
Shortness of breath walking on level ground	2.12	1	0	0.0	0.00	1.0e+00	LRRC32
Medication: Levothyroxine sodium	2.11	2	0	0.0	0.00	1.0e+00	CD247 IL7R
Chest pain or discomfort	2.10	2	0	0.0	0.00	1.0e+00	IL1RL1 ORMDL3
Impedance of arm (left)	1.99	3	1	2.2	0.00	1.0e+00	LRRC32 ORMDL3 PLCL1
Long-standing illness, disability or infirmity	1.98	1	0	0.0	0.00	1.0e+00	KIAA1109
Impedance of whole body	1.79	2	1	2.2	0.00	1.0e+00	LRRC32 PLCL1
HDL Cholesterol	1.63	1	1	2.2	0.00	1.0e+00	ORMDL3
Breast Cancer	1.60	1	1	2.2	0.00	1.0e+00	TLR1
Medication: Blood pressure	1.53	1	0	0.0	0.00	1.0e+00	RRP1B
Impedance of leg (right)	1.52	2	1	2.2	0.00	1.0e+00	PLCL1 RANBP6
Schizophrenia vs Biploar Disorder	1.45	1	0	0.0	0.00	1.0e+00	PLCL1
Hair/balding pattern: Pattern 4	1.45	1	1	2.2	0.00	1.0e+00	IQGAP1
Medication: Atenolol	1.43	1	0	0.0	0.00	1.0e+00	IL1RL1
Myopia	1.41	1	0	0.0	0.00	1.0e+00	ORMDL3
Supplements: Glucosamine	1.36	1	0	0.0	0.00	1.0e+00	GLDC
Medication for cholesterol, blood pressure or diabetes	1.36	1	0	0.0	0.00	1.0e+00	RRP1B
Impedance of leg (left)	1.29	1	1	2.2	0.00	1.0e+00	PLCL1
Birth weight of first child	1.29	1	0	0.0	0.00	1.0e+00	SMAD3
Mouth/teeth dental problems: Mouth ulcers	1.29	1	0	0.0	0.00	1.0e+00	IL7R
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.27	1	0	0.0	0.00	1.0e+00	ORMDL3
Heart disease (siblings)	1.27	1	0	0.0	0.00	1.0e+00	SMAD3
Overall health rating	1.25	1	1	2.2	0.00	1.0e+00	PLCL1
Schizophrenia (2018)	1.22	1	0	0.0	0.00	1.0e+00	PLCL1
Had major operations	1.22	1	0	0.0	0.00	1.0e+00	RRP1B
Schizophrenia (2014)	1.20	1	0	0.0	0.00	1.0e+00	PLCL1
BMI	1.09	3	1	2.2	0.00	1.0e+00	CAMK4 PLCL1 TLR1
Miserableness	1.07	1	0	0.0	0.00	1.0e+00	ORMDL3
Ever depressed for a whole week	1.06	1	0	0.0	0.00	1.0e+00	ORMDL3
Past tobacco smoking	1.02	1	0	0.0	0.00	1.0e+00	GLDC
Age when periods started (menarche)	1.00	1	0	0.0	0.00	1.0e+00	CAMK4
Heel bone mineral density (BMD) T-score, automated (left)	0.99	1	1	2.2	0.00	1.0e+00	IQGAP1
Heel bone mineral density (BMD) T-score, automated (right)	0.98	1	1	2.2	0.00	1.0e+00	IQGAP1
Heel T-Score	0.95	2	1	2.2	0.00	1.0e+00	GLDC IQGAP1
Body mass index (BMI)	0.93	1	1	2.2	0.00	1.0e+00	PLCL1
Arm predicted mass (right)	0.92	1	1	2.2	0.00	1.0e+00	PLCL1
Arm fat-free mass (right)	0.90	1	1	2.2	0.00	1.0e+00	PLCL1
Comparative body size at age 10	0.88	1	0	0.0	0.00	1.0e+00	PLCL1
Arm predicted mass (left)	0.88	1	1	2.2	0.00	1.0e+00	PLCL1
Arm fat-free mass (left)	0.80	1	1	2.2	0.00	1.0e+00	PLCL1
Hip circumference	0.77	1	0	0.0	0.00	1.0e+00	TLR1
Verbal and Numeric Reasoning (VNR)	0.73	1	0	0.0	0.00	1.0e+00	PLCL1
Cardiovascular Disease	0.70	1	0	0.0	0.00	1.0e+00	PLCL1
Whole body water mass	0.69	1	1	2.2	0.00	1.0e+00	PLCL1
Leg predicted mass (right)	0.69	1	1	2.2	0.00	1.0e+00	PLCL1
Whole body fat-free mass	0.68	1	1	2.2	0.00	1.0e+00	PLCL1
Leg fat-free mass (right)	0.68	1	1	2.2	0.00	1.0e+00	PLCL1
Trunk predicted mass	0.66	1	1	2.2	0.00	1.0e+00	PLCL1
Trunk fat-free mass	0.65	1	1	2.2	0.00	1.0e+00	PLCL1
Depressed Affect (Nagel 2018)	0.63	1	0	0.0	0.00	1.0e+00	ORMDL3
Basal metabolic rate	0.62	1	1	2.2	0.00	1.0e+00	PLCL1
Leg predicted mass (left)	0.59	1	1	2.2	0.00	1.0e+00	PLCL1
Leg fat-free mass (left)	0.58	1	1	2.2	0.00	1.0e+00	PLCL1
Waist Hip Ratio (WHR)	0.57	1	0	0.0	0.00	1.0e+00	SMAD3
Arm fat mass (left)	0.54	1	0	0.0	0.00	1.0e+00	PLCL1
Arm fat mass (right)	0.53	1	0	0.0	0.00	1.0e+00	PLCL1
Intelligence (Savage-Jansen 2018)	0.51	1	0	0.0	0.00	1.0e+00	PLCL1
Blood Red Count	0.51	3	1	2.2	0.00	1.0e+00	ORMDL3 PLCL1 TLR1
Weight	0.50	1	0	0.0	0.00	1.0e+00	PLCL1
Comparative height size at age 10	0.49	1	1	2.2	0.00	1.0e+00	IQGAP1
Lung FVC	0.43	1	0	0.0	0.00	1.0e+00	ORMDL3
Leg fat mass (left)	0.43	1	0	0.0	0.00	1.0e+00	PLCL1
Standing height	0.41	1	0	0.0	0.00	1.0e+00	IQGAP1
Blood Platelet Count	0.36	1	0	0.0	0.00	1.0e+00	ORMDL3
Height	0.34	3	1	2.2	0.00	1.0e+00	IL1RL1 IL7R IQGAP1

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Brain Putamen basal ganglia	2	0.321	1.5
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	2	0.394	1.5
GTEx	Brain Cortex	0	0.000	1.4
GTEx	Brain Hypothalamus	2	0.339	1.4
GTEx	Brain Nucleus accumbens basal ganglia	2	0.231	1.4
GTEx	Cells Transformed fibroblasts	6	0.143	1.4
GTEx	Colon Transverse	4	0.194	1.4
GTEx	Esophagus Mucosa	4	0.120	1.4
GTEx	Liver	0	0.000	1.4
GTEx	Pancreas	3	0.184	1.4
GTEx	Spleen	4	0.283	1.4
GTEx	Uterus	1	0.176	1.4
GTEx	Whole Blood	4	0.201	1.4
NTR	Blood	1	0.042	1.4
ROSMAP	Brain Pre-frontal Cortex	9	0.205	1.4
YFS	Blood	5	0.108	1.4
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	0	0.000	1.4
The Cancer Genome Atlas	Colon Adenocarcinoma	1	0.048	1.4
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	5	0.122	1.4
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	2	0.098	1.4
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	4	0.160	1.4
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	0	0.000	1.4
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	1	0.060	1.4
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.000	1.4
The Cancer Genome Atlas	Stomach Adenocarcinoma	2	0.119	1.4
The Cancer Genome Atlas	Testicular Germ Cell Tumors	1	0.078	1.4
GTEx	Adipose Subcutaneous	3	0.086	1.3
GTEx	Adipose Visceral Omentum	3	0.147	1.3
GTEx	Adrenal Gland	2	0.137	1.3
GTEx	Artery Aorta	2	0.067	1.3
GTEx	Artery Coronary	0	0.000	1.3
GTEx	Artery Tibial	3	0.080	1.3
GTEx	Brain Caudate basal ganglia	0	0.000	1.3
GTEx	Brain Cerebellar Hemisphere	1	0.067	1.3
GTEx	Brain Cerebellum	2	0.101	1.3
GTEx	Brain Frontal Cortex BA9	2	0.216	1.3
GTEx	Brain Hippocampus	0	0.000	1.3
GTEx	Breast Mammary Tissue	2	0.101	1.3
GTEx	Breast Mammary Tissue (Male)	2	0.168	1.3
GTEx	Breast Mammary Tissue (Female)	0	0.000	1.3
GTEx	Cells EBV-transformed lymphocytes	1	0.070	1.3
GTEx	Colon Sigmoid	0	0.000	1.3
GTEx	Esophagus Gastroesophageal Junction	0	0.000	1.3
GTEx	Esophagus Muscularis	2	0.062	1.3
GTEx	Heart Atrial Appendage	0	0.000	1.3
GTEx	Heart Left Ventricle	1	0.065	1.3
GTEx	Lung	2	0.070	1.3
GTEx	Muscle Skeletal	2	0.069	1.3
GTEx	Nerve Tibial	1	0.023	1.3
GTEx	Ovary	0	0.000	1.3
GTEx	Pituitary	1	0.090	1.3
GTEx	Prostate	0	0.000	1.3
GTEx	Skin Not Sun Exposed Suprapubic	3	0.122	1.3
GTEx	Skin Sun Exposed Lower leg	2	0.055	1.3
GTEx	Small Intestine Terminal Ileum	0	0.000	1.3
GTEx	Testis	4	0.127	1.3
GTEx	Thyroid	4	0.100	1.3
GTEx	Vagina	0	0.000	1.3
METSIM	Adipose	3	0.065	1.3
CommonMind	Brain Pre-frontal Cortex	4	0.074	1.3
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	1	0.060	1.3
The Cancer Genome Atlas	Breast Invasive Carcinoma	4	0.091	1.3
The Cancer Genome Atlas	Glioblastoma Multiforme	0	0.000	1.3
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	3	0.110	1.3
The Cancer Genome Atlas	Brain Lower Grade Glioma	3	0.070	1.3
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	1	0.090	1.3
The Cancer Genome Atlas	Lung Adenocarcinoma	3	0.102	1.3
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	0	0.000	1.3
The Cancer Genome Atlas	Prostate Adenocarcinoma	2	0.043	1.3
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.3
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.3
The Cancer Genome Atlas	Thyroid Carcinoma	6	0.116	1.3
GTEx	Stomach	0	0.000	1.2
The Cancer Genome Atlas	Esophageal Carcinoma	1	0.146	1.2