Best TWAS P=3.63e-11 · Best GWAS P=2.37e-10 conditioned to 5.06e-06
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | KIAA1109 | 0.11 | 0.00 | lasso | 7 | 0.01 | 5.1e-02 | 5.4 | -5.4 | 5.5e-08 | 0.29 | 0.11 | 0.27 | FALSE |
| 2 | GTEx | Colon Transverse | KIAA1109 | 0.25 | -0.01 | enet | 16 | 0.00 | 4.1e-01 | 6.0 | -5.7 | 1.6e-08 | 0.29 | 0.03 | 0.70 | FALSE |
| 3 | ROSMAP | Brain Pre-frontal Cortex | KIAA1109 | 0.08 | 0.08 | lasso | 7 | 0.07 | 2.5e-09 | 5.2 | -5.2 | 2.1e-07 | 0.44 | 0.56 | 0.44 | FALSE |
| 4 | The Cancer Genome Atlas | Breast Invasive Carcinoma | KIAA1109 | 0.03 | 0.03 | lasso | 1 | 0.02 | 1.2e-05 | 5.2 | -5.2 | 1.5e-07 | 0.33 | 0.15 | 0.76 | FALSE |
| 5 | The Cancer Genome Atlas | Esophageal Carcinoma | KIAA1109 | 0.32 | 0.02 | blup | 45 | 0.02 | 7.4e-02 | 6.0 | -6.6 | 3.6e-11 | 0.30 | 0.01 | 0.48 | TRUE |
| 6 | The Cancer Genome Atlas | Brain Lower Grade Glioma | KIAA1109 | 0.06 | 0.05 | lasso | 2 | 0.03 | 7.1e-05 | 5.2 | -5.3 | 9.3e-08 | 0.26 | 0.31 | 0.53 | FALSE |
| 7 | The Cancer Genome Atlas | Thyroid Carcinoma | KIAA1109 | 0.05 | 0.04 | enet | 3 | 0.05 | 5.4e-06 | 6.0 | -6.0 | 1.6e-09 | 0.38 | 0.02 | 0.98 | FALSE |