Best TWAS P=3.24e-15 · Best GWAS P=8.33e-18 conditioned to NaN
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Spleen | SLC25A46 | 0.25 | 0.00 | enet | 6 | 0.02 | 1.3e-01 | 5.4 | -5.3 | 1.3e-07 | 0.01 | 0.07 | 0.06 | TRUE |
2 | GTEx | Testis | WDR36 | 0.61 | 0.37 | lasso | 10 | 0.34 | 5.7e-16 | -4.5 | -5.3 | 1.5e-07 | 0.57 | 1.00 | 0.00 | FALSE |
3 | METSIM | Adipose | CAMK4 | 0.05 | 0.01 | bslmm | 518 | 0.03 | 8.3e-05 | 5.6 | 5.5 | 3.2e-08 | -0.61 | 0.04 | 0.87 | TRUE |
4 | METSIM | Adipose | TSLP | 0.16 | 0.18 | lasso | 7 | 0.18 | 8.5e-26 | -7.2 | 7.1 | 1.2e-12 | -0.92 | 0.30 | 0.70 | FALSE |
5 | ROSMAP | Brain Pre-frontal Cortex | TSLP | 0.13 | 0.08 | enet | 14 | 0.09 | 4.1e-11 | -6.8 | 5.7 | 1.5e-08 | -0.73 | 1.00 | 0.00 | TRUE |
6 | ROSMAP | Brain Pre-frontal Cortex | CAMK4 | 0.10 | 0.03 | lasso | 4 | 0.04 | 7.8e-06 | 5.8 | -6.4 | 1.4e-10 | 0.59 | 0.91 | 0.08 | TRUE |
7 | YFS | Blood | SLC25A46 | 0.03 | 0.02 | enet | 12 | 0.02 | 9.5e-07 | 5.4 | -7.9 | 3.2e-15 | 0.25 | 0.94 | 0.01 | TRUE |
8 | The Cancer Genome Atlas | Breast Invasive Carcinoma | TSLP | 0.03 | 0.03 | lasso | 2 | 0.03 | 5.5e-07 | -7.1 | 6.1 | 1.2e-09 | -0.84 | 0.62 | 0.38 | FALSE |
9 | The Cancer Genome Atlas | Colon Adenocarcinoma | TSLP | 0.08 | 0.01 | blup | 39 | 0.03 | 5.4e-03 | -6.8 | 5.6 | 2.5e-08 | -0.78 | 0.04 | 0.13 | FALSE |
10 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | TSLP | 0.05 | 0.02 | blup | 39 | 0.02 | 7.9e-04 | -6.8 | 6.0 | 2.3e-09 | -0.77 | 0.08 | 0.67 | FALSE |
11 | The Cancer Genome Atlas | Brain Lower Grade Glioma | TSLP | 0.06 | 0.07 | blup | 39 | 0.06 | 6.4e-07 | -6.8 | 6.7 | 2.1e-11 | -0.88 | 0.72 | 0.28 | FALSE |
12 | The Cancer Genome Atlas | Lung Adenocarcinoma | TSLP | 0.02 | 0.02 | blup | 39 | 0.02 | 1.9e-03 | -7.1 | 6.5 | 6.6e-11 | -0.88 | 0.05 | 0.09 | FALSE |
13 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | TSLP | 0.04 | 0.03 | enet | 6 | 0.02 | 1.6e-03 | -7.0 | 6.3 | 4.0e-10 | -0.86 | 0.06 | 0.60 | TRUE |
14 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | TSLP | 0.12 | 0.11 | lasso | 3 | 0.08 | 6.9e-04 | -7.2 | 7.3 | 3.1e-13 | -0.92 | 0.07 | 0.38 | TRUE |
15 | The Cancer Genome Atlas | Thyroid Carcinoma | TSLP | 0.13 | 0.14 | blup | 39 | 0.15 | 1.4e-14 | -6.8 | 5.6 | 2.8e-08 | -0.75 | 0.82 | 0.18 | TRUE |