TWAS hub - TSLP

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.1569	0.0326	0.0e+00	0.180	0.143	0.172	0.168	0.177	3.7e-26	9.9e-21	6.2e-25	2.2e-24	8.5e-26
2	ROSMAP	Brain Pre-frontal Cortex	0.1259	0.0358	2.0e-07	0.079	0.069	0.085	0.084	0.084	2.2e-10	2.9e-09	4.1e-11	6.5e-11	5.8e-11
3	TCGA	Breast Invasive Carcinoma	0.0309	0.0150	2.2e-06	0.032	0.027	0.028	NA	0.031	2.7e-07	2.8e-06	1.6e-06	NA	5.5e-07
4	TCGA	Colon Adenocarcinoma	0.0850	0.0520	2.2e-03	0.014	0.033	0.030	NA	0.015	5.2e-02	5.4e-03	7.1e-03	NA	4.6e-02
5	TCGA	Head and Neck Squamous Cell Carcinoma	0.0254	0.0176	9.0e-03	0.002	0.006	0.008	NA	0.001	1.7e-01	6.4e-02	3.8e-02	NA	2.2e-01
6	TCGA	Kidney Renal Clear Cell Carcinoma	0.0458	0.0278	8.6e-04	0.022	0.025	0.020	NA	0.021	1.3e-03	7.9e-04	2.3e-03	NA	1.7e-03
7	TCGA	Brain Lower Grade Glioma	0.0599	0.0280	2.4e-07	0.067	0.055	0.055	NA	0.050	4.2e-08	6.4e-07	7.8e-07	NA	2.4e-06
8	TCGA	Lung Adenocarcinoma	0.0232	0.0162	6.1e-03	0.019	0.020	0.006	NA	0.012	2.4e-03	1.9e-03	5.3e-02	NA	1.3e-02
9	TCGA	Lung Squamous Cell Carcinoma	0.0409	0.0285	1.6e-03	0.031	0.018	0.021	NA	0.016	1.7e-04	3.3e-03	1.7e-03	NA	5.3e-03
10	TCGA	Prostate Adenocarcinoma	0.0284	0.0158	2.0e-03	0.012	0.021	0.013	NA	0.012	1.9e-02	2.7e-03	1.5e-02	NA	1.9e-02
11	TCGA	Testicular Germ Cell Tumors	0.1160	0.0670	1.0e-03	0.106	0.081	0.055	NA	0.084	1.4e-04	8.4e-04	5.2e-03	NA	6.9e-04
12	TCGA	Thyroid Carcinoma	0.1270	0.0440	1.1e-14	0.136	0.151	0.149	NA	0.151	3.5e-13	1.4e-14	2.3e-14	NA	1.5e-14

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Allergy or Eczema	63.6	167.4	231.0	15.1	12.2	13.4	12.4	9.6	12.4	14.0	13.8	13.5	10.9	15.2	11.6
Allergy	63.5	146.1	198.8	-14.1	-11.2	-12.4	-12.0	-8.9	-12.3	-12.8	-12.5	-12.9	-10.3	-14.1	-10.5
Hayfever, allergic rhinitis or eczema	61.2	132.8	185.0	13.4	10.5	11.8	11.2	8.9	11.0	12.3	12.3	12.2	10.0	13.6	10.1
Asthma	29.1	57.4	83.8	9.2	6.9	7.7	7.4	4.1	8.9	7.8	7.3	8.4	6.3	9.0	6.4
Asthma (self-reported)	27.4	54.5	79.7	8.9	6.8	7.5	7.2	3.8	8.7	7.6	7.1	8.2	6.1	8.8	6.2
Hayfever/allergic rhinitis (self-reported)	27.0	35.7	53.2	7.1	5.7	6.1	5.6	3.1	6.0	6.7	6.5	6.3	4.7	7.3	5.6
Blood Eosinophil Count	25.6	196.9	320.4	16.9	13.3	15.4	9.7	2.3	13.3	17.9	16.4	12.8	3.2	17.4	17.9
Respiratory disease	22.2	49.5	74.7	8.6	6.3	7.2	6.7	3.6	8.4	7.5	6.8	7.8	5.3	8.4	6.2
Wheeze or whistling in the chest in last year	12.1	21.6	31.8	5.6	4.7	4.8	4.7	1.9	5.6	5.1	4.4	4.8	3.2	5.4	4.2
Medication: Ventolin 100micrograms inhaler	7.4	9.5	16.0	3.9	2.8	3.1	2.3	0.7	3.5	3.3	2.8	3.9	2.1	4.0	2.8
Average weekly spirits intake	6.1	7.6	10.3	-3.1	-3.0	-3.0	-2.6	-2.8	-3.2	-2.4	-2.4	-2.8	-2.5	-2.8	-2.0
Medication: Seretide 50 evohaler	5.9	6.7	11.1	3.1	2.5	2.7	2.0	0.9	2.6	3.3	2.7	3.0	0.8	2.9	3.2
Medication: Blood pressure	4.0	7.1	12.6	2.8	2.4	2.7	2.5	3.5	2.0	2.1	2.5	2.9	3.5	2.9	1.4
Ever had bowel cancer screening	3.8	4.5	7.3	-2.3	-2.7	-2.4	-2.2	-1.8	-2.4	-1.7	-2.1	-1.2	-2.3	-2.4	-1.5
Alcohol drinker status: Never	3.6	4.3	7.3	-2.5	-1.6	-2.1	-1.7	-1.6	-1.4	-2.2	-2.5	-2.4	-1.8	-2.7	-2.0
Frequency of unenthusiasm / disinterest in last 2 weeks	3.4	4.5	11.2	-2.2	-1.2	-2.0	-1.6	-3.3	-0.7	-1.9	-2.7	-1.7	-2.8	-2.4	-1.4
Back pain experienced in last month	3.4	4.9	7.7	-2.5	-2.0	-2.4	-2.2	-2.4	-2.8	-2.0	-2.1	-2.1	-1.7	-2.2	-2.0
Risk taking	3.4	5.0	7.7	-2.4	-2.0	-2.2	-1.5	-2.5	-1.1	-2.6	-2.8	-2.4	-1.7	-2.5	-2.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.1	3.7	11.0	-1.6	-1.7	-1.4	-2.5	-3.0	-2.0	-0.4	-1.0	-2.0	-3.3	-1.5	0.1
Taking other prescription medications	3.0	4.6	7.8	2.7	1.7	2.2	1.6	0.4	2.2	2.6	1.9	2.6	0.3	2.8	2.5
Medication: Atorvastatin	3.0	3.7	6.1	-2.0	-2.3	-2.1	-1.7	-1.2	-2.0	-2.3	-1.8	-2.5	-0.8	-1.7	-2.2
Falls in the last year	2.9	4.0	6.7	-2.2	-2.1	-1.9	-1.8	-1.1	-1.6	-1.8	-2.2	-2.2	-2.6	-2.5	-1.4
Medication for cholesterol, blood pressure or diabetes	2.9	4.8	9.6	-2.2	-1.9	-2.0	-2.4	-2.7	-1.5	-1.7	-2.2	-2.2	-3.1	-2.4	-1.2
Cholesterol lowering medication	2.9	4.3	5.8	-2.1	-2.3	-2.2	-2.4	-1.1	-2.2	-2.2	-2.1	-2.3	-1.5	-1.9	-2.2
Medication for cholesterol	2.7	4.1	5.8	2.2	2.4	2.3	2.2	0.7	2.1	2.3	2.2	1.7	1.5	2.1	2.1
Maternal smoking around birth	2.6	3.8	7.3	-2.0	-2.1	-2.0	-2.3	-1.5	-2.4	-1.6	-1.2	-2.7	-1.5	-1.6	-1.7
Chronotype (morning person)	2.5	5.7	14.1	-2.7	-2.0	-2.4	-0.6	-1.7	-1.0	-3.2	-2.8	-2.6	1.0	-2.6	-3.8
Age at first live birth	2.5	4.4	6.7	2.3	1.7	2.2	2.4	1.4	1.8	1.9	2.4	1.9	2.6	2.5	1.5
Leg pain on walking	2.5	3.1	6.5	-2.3	-1.1	-2.0	-1.1	-0.6	-1.6	-2.1	-2.3	-1.5	-0.9	-2.5	-1.9
Unable to work because of sickness or disability	2.5	3.3	4.9	1.8	2.0	1.7	2.2	2.0	2.1	1.7	1.4	2.0	1.9	1.5	1.2
Body Mass Index (BMI) (2010)	2.4	3.3	4.9	-2.0	-1.8	-2.1	-1.5	-1.1	-1.6	-2.1	-2.2	-1.6	-1.3	-2.1	-1.9
Systolic blood pressure, automated reading	2.4	6.8	10.3	-2.9	-3.0	-3.1	-2.4	-2.1	-2.6	-2.8	-2.7	-2.3	-0.9	-2.6	-3.2
Number of children fathered	2.4	2.8	4.0	-1.8	-1.9	-1.8	-1.5	-1.3	-1.1	-1.6	-1.7	-1.7	-1.7	-2.0	-1.5
Medication: Omeprazole	2.4	2.9	4.5	-1.9	-1.8	-2.0	-1.7	-1.6	-2.1	-1.6	-1.5	-1.7	-1.6	-1.7	-1.2
Mother’s age at death	2.4	3.0	4.8	-1.9	-1.4	-1.7	-1.6	-1.9	-1.0	-1.7	-1.9	-1.7	-2.2	-2.2	-0.9
Coronary Artery Disease (CAD)	2.3	2.8	4.3	1.8	2.0	1.6	1.3	2.0	2.1	1.8	1.3	1.9	0.4	1.2	1.8
Diabetes (mother)	2.3	3.0	4.2	-1.9	-1.8	-2.0	-1.5	-1.2	-1.7	-1.9	-1.9	-1.5	-0.8	-1.9	-2.0
Health satisfaction	2.3	3.0	5.8	-1.7	-2.4	-2.1	-1.9	-1.6	-2.1	-1.6	-1.7	-1.1	-1.2	-1.5	-1.5
Mineral and other dietary supplements	2.3	3.0	6.2	-1.8	-0.9	-1.5	-1.9	-1.7	-0.7	-1.9	-2.0	-2.5	-1.9	-2.0	-1.4
Pulse wave peak to peak time	2.2	2.5	5.2	1.5	1.6	1.6	1.9	2.3	1.5	1.1	1.3	1.7	2.0	1.3	0.8
Breast cancer (self-reported)	2.2	2.6	5.9	-1.7	-1.4	-1.5	-1.6	-1.0	-2.0	-1.3	-1.2	-2.0	-2.4	-1.8	-0.3
Wears glasses or contact lenses	2.2	2.5	4.0	-1.9	-1.4	-1.8	-1.3	-0.5	-1.7	-1.8	-1.5	-2.0	-0.9	-1.7	-1.7
Alzheimer’s Disease (in father)	2.1	2.2	5.7	-1.6	-1.3	-1.5	-1.4	-2.4	-1.7	-1.1	-1.2	-1.4	-1.3	-1.5	-0.9
Bipolar Disorder (2011)	2.1	2.1	3.4	1.5	0.8	1.4	1.4	1.8	1.1	1.4	1.5	1.6	1.8	1.8	0.8
Diastolic blood pressure, automated reading	2.1	6.7	12.6	-2.7	-3.0	-3.1	-2.1	-2.2	-2.0	-3.1	-2.9	-1.9	-0.2	-2.5	-3.6
High blood pressure (mother)	2.0	2.8	4.6	-1.8	-1.4	-1.8	-2.1	-1.4	-2.0	-1.3	-1.5	-1.6	-2.1	-1.6	-1.1
Had menopause	2.0	2.5	3.7	-1.8	-1.6	-1.9	-1.5	-0.1	-1.4	-1.9	-1.9	-1.2	-0.9	-1.9	-1.9
Diverticular disease/diverticulitis (self-reported)	1.9	2.2	4.6	-1.7	-1.3	-1.5	-0.6	-1.3	-0.4	-2.1	-1.9	-1.5	-0.6	-2.0	-1.8
Supplements: Fish oil (including cod liver oil)	1.9	2.5	6.1	1.7	0.5	1.3	1.3	1.5	0.6	1.6	1.8	2.5	1.7	2.0	1.2
Type 2 Diabetes (T2D) (2012)	1.8	2.1	5.1	-1.6	-1.2	-1.5	-1.0	1.1	-1.6	-2.0	-1.7	-0.9	0.4	-1.3	-2.2
Friendships satisfaction	1.8	2.3	4.0	-1.5	-1.8	-1.6	-1.8	-1.6	-2.0	-1.0	-1.0	-1.8	-1.5	-1.0	-1.2
Average weekly beer plus cider intake	1.8	2.6	6.6	1.7	1.3	1.4	0.8	2.6	0.7	1.2	1.4	2.3	2.0	1.7	0.9
Commuting to job workplace: Cycle	1.8	2.2	3.2	1.5	1.8	1.7	1.6	1.7	1.8	1.4	1.3	1.2	1.1	1.2	1.3
Hip circumference	1.7	7.2	11.4	-2.8	-3.4	-3.0	-2.5	-2.8	-2.5	-2.8	-3.0	-1.8	-1.9	-2.7	-2.5
Number of full brothers	1.7	2.2	6.2	-0.9	-1.3	-0.9	-2.0	-2.5	-2.4	-0.1	-0.2	-1.4	-2.1	-0.3	0.3
Medication: Blood pressure	1.7	3.1	4.3	-1.9	-2.1	-2.0	-1.9	-0.8	-1.8	-2.0	-2.0	-1.3	-1.3	-1.8	-1.8
Pulse wave Arterial Stiffness index	1.6	1.8	4.5	-1.2	-1.4	-1.3	-1.6	-2.1	-1.2	-0.8	-1.0	-1.4	-1.8	-1.0	-0.5
Exposure to tobacco smoke outside home	1.6	2.2	4.4	-1.7	-1.1	-1.6	-0.7	-0.6	-0.8	-2.0	-2.1	-1.3	-0.2	-1.9	-2.0
Medication: Ibuprofen	1.6	1.9	3.3	-1.4	-1.6	-1.4	-1.3	-1.8	-1.2	-1.1	-1.2	-1.6	-1.1	-1.3	-1.3
Major Depression (MDD)	1.5	1.8	2.6	-1.4	-1.6	-1.5	-1.4	-0.8	-1.2	-1.4	-1.6	-1.0	-1.0	-1.3	-1.5
Medication: Levothyroxine sodium	1.5	2.5	6.8	-1.4	-2.1	-1.5	-1.6	-2.6	-1.7	-0.9	-1.1	-1.7	-1.9	-0.8	-0.9
Medication: Ramipril	1.5	2.0	3.3	1.5	1.7	1.6	1.5	1.5	1.8	1.1	0.9	1.5	0.8	1.4	1.1
Arm fat percentage (left)	1.5	5.9	8.0	-2.7	-2.8	-2.8	-2.1	-2.3	-2.3	-2.6	-2.8	-1.6	-2.1	-2.7	-2.0
Pain experienced in last month	1.5	2.4	3.9	1.7	2.0	1.8	1.2	1.0	1.5	1.5	1.5	1.8	0.8	1.6	1.8
Supplements: Calcium	1.5	1.6	6.5	0.9	0.4	0.8	1.3	2.5	0.5	0.3	0.6	1.4	2.5	0.9	-0.4
Medication for hormone replacement therapy	1.4	1.6	2.7	-1.4	-1.6	-1.5	-0.8	-1.6	-0.6	-1.1	-1.3	-1.2	-1.1	-1.2	-1.1
Tinnitus: Yes, but not now, but have in the past	1.4	1.5	2.9	-1.2	-1.7	-1.3	-0.5	-1.1	-0.5	-1.4	-1.6	-1.0	-0.9	-1.6	-1.1
Had other major operations	1.4	1.7	4.7	-1.4	-2.2	-1.4	-0.9	-0.6	-0.9	-1.4	-1.4	-1.1	-0.8	-1.6	-1.3
Arm fat percentage (right)	1.4	5.5	7.8	-2.6	-2.8	-2.7	-2.0	-2.3	-2.1	-2.5	-2.8	-1.5	-2.0	-2.5	-1.9
Alcohol intake versus 10 years previously	1.4	2.0	3.0	1.6	1.3	1.4	0.9	1.7	1.1	1.6	1.3	1.7	1.4	1.7	0.9
Hypothyroidism/myxoedema (self-reported)	1.4	2.7	8.4	-1.4	-1.9	-1.4	-1.8	-2.9	-1.7	-0.9	-1.0	-1.8	-2.1	-0.9	-0.6
Number of full sisters	1.4	1.7	2.9	-1.5	-0.6	-1.3	-1.5	-1.4	-0.8	-1.4	-1.5	-0.9	-1.7	-1.6	-0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.4	1.7	2.4	-1.4	-1.2	-1.5	-1.1	-0.9	-1.3	-1.4	-1.3	-1.5	-1.0	-1.4	-1.4
Alcohol drinker status: Previous	1.4	1.6	3.5	1.3	1.9	1.5	0.6	0.5	0.7	1.6	1.4	1.0	-0.4	1.4	1.9
Depression (Nagel 2018)	1.3	1.9	3.6	-1.4	-1.0	-1.3	-1.1	-1.9	-0.5	-1.3	-1.8	-1.0	-1.7	-1.8	-1.1
BMI	1.3	7.8	11.4	-2.9	-3.2	-3.1	-2.8	-3.4	-2.5	-2.7	-2.9	-2.1	-2.6	-2.8	-2.1
Diabetes (father)	1.3	1.7	3.4	1.4	0.7	1.3	1.2	1.9	1.2	1.5	1.4	1.2	1.0	1.3	1.1
Chronic bronchitis/emphysema (father)	1.3	1.6	3.4	-1.0	-1.8	-1.3	-1.8	-0.9	-1.7	-1.1	-1.2	-0.4	-0.7	-0.6	-1.3
Body mass index (BMI)	1.3	5.5	8.8	-2.5	-3.0	-2.7	-2.2	-2.3	-2.2	-2.5	-2.6	-1.5	-1.6	-2.4	-2.2
Pulse wave reflection index	1.2	1.5	4.3	-1.0	-1.2	-1.0	-1.2	-1.7	-1.2	-0.6	-0.7	-1.5	-2.1	-0.8	-0.3
Chronic bronchitis/emphysema (mother)	1.2	1.4	2.3	1.3	0.9	1.0	1.3	0.4	1.4	1.5	1.3	1.4	0.7	1.1	1.3
Knee pain experienced in last month	1.2	1.8	5.9	-1.2	-1.6	-1.4	-0.4	-0.1	-1.0	-1.9	-1.2	-1.0	1.3	-0.9	-2.4
Number of self-reported non-cancer illnesses	1.2	2.1	4.3	1.8	1.0	1.3	1.2	0.0	1.8	1.8	1.3	2.1	0.7	1.8	1.3
Medication: Lisinopril	1.2	1.6	4.3	1.1	0.4	0.9	1.4	2.1	0.6	1.0	1.1	1.6	1.8	1.1	0.6
Leg fat percentage (left)	1.2	4.5	6.7	-2.4	-2.5	-2.5	-1.7	-1.9	-1.9	-2.5	-2.6	-1.2	-1.3	-2.3	-2.1
Medication: Omeprazole (e.g. Zanprol)	1.2	1.5	2.7	-1.2	-1.5	-1.5	-1.2	-1.0	-1.7	-1.1	-0.9	-1.1	-0.9	-1.1	-1.0
Alzheimer’s Disease (in mother)	1.1	1.3	3.3	1.1	1.2	1.0	1.8	1.1	1.6	0.9	0.6	1.2	0.7	0.7	1.2
Supplements: Zinc	1.1	1.2	2.0	1.3	0.7	1.2	1.1	0.9	1.0	1.1	1.1	1.3	1.1	1.4	0.7
Birth weight of first child	1.1	2.0	2.9	1.5	1.3	1.6	1.2	1.3	0.9	1.4	1.4	1.7	1.6	1.7	1.1
Leg fat percentage (right)	1.1	4.1	6.1	-2.2	-2.5	-2.4	-1.6	-1.8	-1.9	-2.4	-2.4	-1.2	-1.2	-2.1	-2.0
Osteoarthritis (self-reported)	1.1	1.5	3.2	-1.1	-1.4	-1.2	-0.8	-1.4	-0.4	-1.6	-1.8	-0.2	0.3	-1.3	-1.7
Commuting to job workplace: Public transport	1.1	1.3	2.1	-1.4	-1.0	-1.3	-1.1	-1.3	-1.1	-0.9	-1.2	-1.1	-1.4	-1.3	-0.8
Pain type(s) experienced in last month: Hip pain	1.1	1.4	2.4	-1.2	-1.5	-1.5	-1.2	-1.4	-1.2	-0.9	-1.3	-0.5	-1.0	-1.2	-1.1
Fractured/broken bones in last 5 years	1.1	1.4	2.0	-1.4	-1.0	-1.2	-1.2	-1.4	-1.2	-1.0	-1.2	-1.0	-1.0	-1.4	-1.0
Age started oral contraceptive pill	1.1	1.3	2.9	-1.3	-1.3	-1.4	-0.5	-0.5	-0.8	-1.4	-1.4	-1.1	-0.1	-1.2	-1.7
Prostate Cancer	1.0	1.4	2.4	1.5	1.5	0.0	0.9	0.5	1.0	1.5	1.5	1.2	0.6	1.5	1.5
Ever used hormone-replacement therapy (HRT)	1.0	1.2	3.2	-1.1	-1.6	-1.4	-0.3	-0.3	-0.3	-1.4	-1.5	-0.4	0.2	-1.1	-1.8
Hair/balding pattern: Pattern 2	1.0	1.3	4.4	-0.9	-0.9	-0.9	-1.2	-2.1	-0.5	-1.3	-1.5	-0.5	-0.8	-0.9	-1.0
Illnesses of mother	1.0	1.3	2.0	1.3	1.2	1.3	0.8	1.2	0.9	1.3	1.4	0.7	1.1	1.1	1.0
Body fat percentage	1.0	3.8	6.5	-2.2	-2.4	-2.2	-1.4	-1.9	-1.7	-2.2	-2.5	-0.7	-1.6	-2.2	-1.6
Family relationship satisfaction	1.0	1.3	2.0	-1.1	-1.4	-1.4	-1.0	-1.3	-1.4	-0.8	-1.0	-1.1	-1.1	-0.8	-1.0
Average weekly red wine intake	1.0	1.5	3.7	-1.3	-1.4	-1.3	-0.4	-1.9	-0.1	-1.2	-1.3	-1.2	-0.9	-1.4	-1.2
Ulcerative Colitis (UC)	0.9	1.6	2.5	1.2	1.5	1.4	1.5	1.3	1.6	1.1	0.8	1.2	1.4	1.1	0.7
Primary Biliary Cirrhosis	0.9	1.3	2.9	-1.2	-1.2	-1.1	-1.4	-0.7	-1.3	-1.0	-0.8	-1.7	-0.9	-1.0	-1.2
Lung FEV1/FVC ratio	0.9	4.8	7.0	-2.6	-2.5	-2.3	-2.0	-1.2	-2.5	-2.0	-2.0	-2.0	-2.2	-2.6	-1.5
Townsend deprivation index at recruitment	0.9	1.2	2.7	-1.1	-1.0	-0.9	-1.4	-1.1	-1.4	-0.7	-0.9	-1.2	-1.6	-0.8	-0.6
Noisy workplace	0.9	1.2	2.2	-1.4	-0.7	-1.1	-0.6	-0.8	-0.9	-1.4	-1.3	-1.1	-0.5	-1.5	-1.2
Birth weight	0.9	2.0	3.1	1.6	1.3	1.5	1.5	1.4	1.0	1.5	1.6	1.4	1.2	1.7	1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.1	3.4	-0.9	-0.8	-1.0	-0.6	1.0	-1.0	-1.2	-1.0	-0.4	1.1	-0.8	-1.9
Arm fat mass (left)	0.9	3.7	6.3	-2.0	-2.5	-2.2	-1.8	-1.9	-1.9	-2.0	-2.3	-0.9	-1.6	-1.9	-1.7
Basal cell carcinoma (self-reported)	0.9	1.0	2.6	0.8	0.8	1.0	1.2	1.2	0.8	0.5	0.8	1.4	1.6	0.8	0.4
Trunk fat percentage	0.8	3.2	5.6	-1.9	-2.1	-2.0	-1.3	-2.0	-1.4	-1.9	-2.4	-0.6	-1.8	-2.1	-1.2
Stomach or abdominal pain in last month	0.8	1.0	2.6	-1.0	-0.4	-1.0	-0.6	-1.5	-0.2	-0.6	-1.0	-1.6	-0.9	-1.0	-1.0
Lung cancer (father)	0.8	0.9	2.3	-0.9	-0.8	-0.9	0.5	0.5	0.7	-1.3	-1.2	-0.2	0.2	-1.5	-1.2
Arm fat mass (right)	0.8	3.2	6.1	-1.8	-2.5	-2.1	-1.5	-1.8	-1.6	-1.9	-2.2	-0.9	-1.4	-1.8	-1.6
Peak expiratory flow (PEF)	0.8	1.9	3.8	1.5	1.7	1.6	0.9	-0.2	1.3	1.8	1.9	0.2	0.1	1.5	1.8
Mouth/teeth dental problems: Loose teeth	0.8	0.9	1.6	-1.1	-0.4	-1.0	-0.9	-1.2	-0.4	-1.3	-1.0	-1.0	-1.1	-0.9	-0.7
High cholesterol (Self-reported)	0.8	1.4	3.6	-1.0	-1.7	-1.3	-0.9	0.4	-1.5	-1.3	-0.8	-0.9	0.8	-0.5	-1.9
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	3.3	1.1	0.8	0.8	0.9	1.2	0.9	0.9	0.7	1.8	1.0	1.0	0.6
Schizophrenia (2018)	0.7	1.5	2.4	1.3	1.5	1.4	0.7	0.6	1.0	1.5	1.4	1.4	0.6	1.4	1.5
Ovarian Cancer	0.7	1.0	3.5	0.9	0.9	0.8	1.5	0.3	1.9	0.8	0.5	0.9	1.0	0.5	0.6
Schizophrenia (2014)	0.7	1.4	2.6	1.3	1.6	1.4	0.6	-0.1	1.0	1.5	1.4	1.0	0.3	1.4	1.5
Blood Red Count	0.7	7.1	9.1	-2.9	-2.5	-2.7	-3.0	-2.8	-2.6	-2.6	-2.8	-2.5	-2.3	-2.8	-2.3
Fluid intelligence score	0.7	1.5	3.6	1.1	1.9	1.1	1.5	0.6	1.4	1.1	1.0	1.1	1.5	1.1	0.7
Happiness	0.7	0.8	1.4	-0.8	-1.2	-1.1	-1.1	-1.1	-1.1	-0.5	-0.7	-0.8	-1.2	-0.5	-0.6
Medication: Paracetamol	0.7	1.2	3.6	0.9	1.0	1.0	1.4	1.4	1.2	0.7	0.3	1.9	1.3	0.6	0.7
Migraine (self-reported)	0.7	0.8	2.2	0.9	1.0	0.9	0.6	0.5	0.3	1.3	1.0	0.9	-0.0	0.9	1.5
Handedness (chirality/laterality): Left-handed	0.7	0.9	2.0	1.0	1.4	1.1	0.8	0.3	0.6	0.8	1.0	0.8	1.1	1.3	0.6
Eye problems/disorders: Glaucoma	0.7	0.8	3.7	-0.2	-0.8	-0.5	0.4	1.1	-0.1	-0.9	-0.4	0.0	1.9	-0.3	-1.5
Medication: Paracetamol	0.7	1.1	3.4	0.8	0.9	0.7	1.4	1.6	1.1	0.3	0.0	1.8	1.5	0.4	0.3
Schizophrenia vs Biploar Disorder	0.6	0.8	3.0	0.3	0.9	0.6	1.3	-1.6	1.7	-0.0	-0.0	-0.5	0.9	0.3	-0.2
Irritable Bowel Disease (IBD)	0.6	1.4	2.5	1.1	1.4	1.2	1.6	1.3	1.6	1.1	0.8	1.2	1.1	0.9	0.8
Heel T-Score	0.6	5.1	7.3	-2.5	-2.0	-2.2	-2.2	-2.7	-1.8	-2.5	-2.7	-1.9	-2.0	-2.4	-2.0
Cardiovascular Disease	0.6	1.9	3.7	-1.5	-1.9	-1.8	-1.2	-0.3	-1.9	-1.5	-1.2	-0.9	-0.2	-1.3	-1.6
Relative age of first facial hair	0.6	1.3	4.2	-1.1	-0.7	-0.8	-2.0	0.3	-1.9	-0.8	-0.5	-1.2	-1.2	-0.8	-0.5
Ever had hysterectomy (womb removed)	0.6	0.7	2.5	0.7	-0.2	0.4	0.6	1.6	0.5	0.5	0.3	1.4	1.2	0.5	-0.1
Impedance of leg (right)	0.6	3.1	5.4	1.7	2.2	1.9	2.3	1.5	1.9	1.4	1.6	1.4	1.9	1.6	1.3
Impedance of leg (left)	0.6	2.9	5.3	1.6	2.2	1.9	2.3	1.2	2.0	1.4	1.5	1.3	1.7	1.4	1.4
Waist circumference	0.6	2.0	4.5	-1.2	-2.1	-1.7	-1.7	-1.4	-1.7	-1.2	-1.5	-0.3	-1.2	-1.0	-1.2
Time employed in main current job	0.6	0.7	1.6	0.8	0.6	0.6	1.2	0.7	1.2	0.7	0.5	1.3	0.6	0.5	0.8
Depression (self-reported)	0.6	0.7	1.8	1.0	0.4	0.6	0.8	0.4	0.9	0.5	0.5	1.0	1.4	1.2	-0.2
Loud music exposure frequency	0.6	0.7	1.2	0.9	0.6	0.8	0.8	1.0	1.0	1.0	0.6	1.1	0.5	0.7	0.7
Blood clot in the leg (DVT)	0.6	0.8	2.6	1.0	0.6	0.6	0.9	1.0	1.0	0.6	0.5	1.6	1.0	0.8	0.3
Angina (self-reported)	0.6	0.8	2.4	0.9	0.7	0.9	0.2	-0.5	0.2	1.4	1.1	0.2	-0.8	1.0	1.6
Medication: Allopurinol	0.6	0.9	1.5	1.1	1.0	1.0	0.9	-0.3	1.2	1.1	0.7	0.7	0.2	1.1	1.0
Heart disease (mother)	0.6	0.7	2.2	-0.8	-0.8	-0.7	-0.7	-1.5	-0.6	-1.1	-0.8	-0.8	-0.1	-0.4	-1.1
Suffer from ‘nerves’	0.6	0.9	2.3	-0.9	-0.6	-0.9	-1.5	0.3	-1.3	-1.0	-0.8	-1.2	-0.1	-0.8	-1.3
Had major operations	0.6	0.7	2.0	-0.5	-1.0	-0.8	-1.2	-0.8	-1.4	-0.6	-0.3	-1.1	-0.1	-0.0	-1.0
Age at last live birth	0.6	0.9	3.3	0.7	0.5	0.6	1.1	1.5	0.5	0.3	0.6	1.2	1.8	0.7	-0.0
Qualifications: nursing, teaching	0.6	0.9	3.1	0.8	1.1	1.1	0.8	-0.3	1.0	1.2	0.8	0.5	-0.9	0.5	1.8
Illnesses of father: High blood pressure	0.6	0.7	1.8	-0.9	-1.3	-0.9	-0.5	0.3	-1.0	-1.0	-0.9	-0.2	0.4	-0.8	-1.3
Irritability	0.6	1.1	3.9	-0.8	-0.6	-0.7	-1.9	-0.4	-2.0	-0.4	-0.4	-0.6	-1.7	-0.7	0.1
Myopia	0.6	0.9	2.0	1.1	0.6	0.9	0.7	-0.0	0.6	1.4	1.2	0.5	-0.1	1.2	1.4
Bipolar Disorder or Schizophrenia	0.5	1.2	2.9	1.2	1.0	1.1	0.2	0.8	0.4	1.5	1.3	1.3	-0.2	1.2	1.7
Ulcerative Colitis	0.5	0.7	1.3	1.0	0.9	1.1	0.7	0.5	1.1	0.9	0.7	0.7	0.2	1.1	0.7
Hypothyroidism (self reported)	0.5	1.2	4.8	-0.7	-1.5	-0.7	-0.9	-2.2	-0.8	-0.7	-0.4	-1.6	-1.0	-0.3	-0.5
Severe depression (siblings)	0.5	0.5	2.3	-0.5	0.4	0.0	-0.7	-1.4	-0.0	-0.3	-0.5	-0.6	-1.5	-0.4	0.2
Trunk fat mass	0.5	2.1	3.8	-1.5	-1.9	-1.7	-1.1	-1.5	-1.2	-1.5	-1.9	-0.4	-1.3	-1.6	-1.1
Diabetes (self-reported)	0.5	0.7	2.6	-0.8	-0.7	-0.7	-1.2	0.1	-1.6	-0.4	-0.3	-0.9	-1.2	-0.6	-0.0
Hair/balding pattern: Pattern 3	0.5	0.7	1.3	0.8	0.9	0.7	1.0	0.4	1.0	1.0	0.7	1.1	0.2	0.7	1.1
Exposure to tobacco smoke at home	0.5	0.6	1.0	-0.7	-0.9	-1.0	-0.6	-0.8	-0.4	-0.8	-0.9	-0.5	-0.9	-0.9	-0.5
Breastfed as a baby	0.5	0.6	2.0	-0.5	-0.7	-0.8	-0.2	1.1	-0.1	-0.9	-0.8	-0.1	0.8	-0.6	-1.4
Ever highly irritable/argumentative for 2 days	0.5	0.6	2.3	0.6	1.0	0.4	1.1	1.5	0.9	0.2	0.2	0.9	1.0	0.4	0.1
Qualifications: O levels/GCSEs or equivalent	0.5	0.7	1.9	0.9	0.6	0.6	0.6	1.3	0.5	0.8	0.7	1.4	0.6	0.9	0.7
Headache pain in last month	0.5	0.8	2.0	-1.0	-1.1	-1.1	-0.6	-0.1	-0.6	-0.8	-1.3	-0.6	-0.7	-1.4	-0.8
Glaucoma (self-reported)	0.5	0.5	1.5	-0.7	-1.0	-0.8	-0.3	-0.8	-0.4	-0.9	-0.6	-0.4	0.7	-0.6	-1.2
Gout (self-reported)	0.5	0.7	2.0	0.9	1.4	0.9	0.9	-0.4	1.2	0.7	0.4	0.8	0.2	0.8	0.8
Whole body fat mass	0.5	2.1	4.3	-1.5	-2.1	-1.8	-1.1	-1.3	-1.3	-1.6	-1.9	-0.3	-1.0	-1.5	-1.3
Leg fat mass (right)	0.5	1.7	3.6	-1.4	-1.9	-1.6	-1.1	-1.2	-1.3	-1.4	-1.6	-0.3	-0.9	-1.2	-1.1
Diabetes diagnosed by doctor	0.5	0.8	2.5	-0.7	-0.8	-0.7	-1.4	-0.3	-1.3	-0.2	-0.3	-1.2	-1.6	-0.7	0.1
Medication: Bendroflumethiazide	0.5	0.8	2.1	-0.9	-0.8	-0.8	-0.0	0.4	-0.2	-1.4	-1.3	-0.5	0.6	-1.0	-1.5
Ever smoked	0.5	0.8	3.7	-0.1	-0.4	-0.0	-1.3	0.0	-1.9	0.6	0.5	0.3	-1.6	0.3	1.1
Number of operations (self-reported)	0.5	0.7	1.3	-0.9	-1.1	-1.0	-0.4	-0.1	-0.6	-1.0	-0.9	-0.8	-0.3	-1.0	-1.1
Leg fat mass (left)	0.5	2.0	4.0	-1.4	-2.0	-1.7	-1.2	-1.3	-1.3	-1.5	-1.7	-0.4	-0.9	-1.4	-1.2
Reaction Time	0.4	0.7	1.6	-0.9	-1.0	-0.8	-0.5	-1.0	-0.2	-0.9	-1.2	-0.4	-1.0	-1.0	-0.5
Rheumatoid Arthritis	0.4	0.5	1.1	0.6	0.7	0.7	0.9	-0.2	0.7	0.7	1.1	0.5	0.9	0.7	0.7
Blood White Count	0.4	2.7	6.8	1.8	0.9	1.4	2.4	0.2	2.6	1.5	1.2	1.9	1.5	1.5	1.3
Systolic Blood Pressure	0.4	2.1	6.0	-1.3	-1.7	-1.7	-1.0	-0.5	-1.2	-1.7	-1.4	-1.4	0.8	-1.2	-2.4
Hand grip strength (left)	0.4	1.1	2.8	1.2	0.5	1.0	1.2	1.0	1.4	0.5	0.8	1.1	1.7	1.1	0.3
Hearing difficulty/problems: Yes	0.4	0.6	2.3	-0.5	-0.8	-0.6	-1.0	-0.8	-1.1	-0.3	-0.5	-0.3	-1.5	-0.4	0.1
Angina	0.4	0.6	1.8	0.6	0.5	0.7	0.0	-0.4	-0.1	1.2	1.0	0.0	-0.9	0.8	1.4
Relative age voice broke	0.4	0.6	1.7	-0.7	-0.9	-0.6	-0.7	0.9	-1.3	-0.7	0.0	-1.1	0.2	-0.4	-0.7
Age when periods started (menarche)	0.4	0.9	3.3	-0.9	0.5	-0.4	-0.1	-0.1	0.3	-0.7	-1.5	0.3	-1.8	-1.7	0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	3.2	-0.7	-1.2	-0.7	-0.7	-1.8	-0.5	-1.2	-0.9	-1.0	-0.1	-0.4	-1.2
Multivitamins +/- minerals	0.4	0.5	1.9	0.5	-0.8	-0.1	-0.2	1.4	-0.6	0.1	0.4	0.5	1.2	0.7	-0.6
Past tobacco smoking	0.4	0.7	3.5	0.3	0.8	0.4	1.2	0.2	1.9	-0.2	-0.2	-0.4	1.2	-0.1	-0.7
Alcohol usually taken with meals	0.4	0.6	1.8	-1.0	-0.7	-0.9	0.2	-0.7	0.2	-0.6	-1.1	-0.4	-0.8	-1.3	-0.4
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.7	2.1	-0.8	-0.3	-0.9	-0.3	-0.8	0.0	-1.1	-1.4	-0.5	-0.6	-1.0	-0.9
Financial difficulties in last 2 years	0.4	0.5	2.0	0.9	0.4	0.7	0.2	1.4	0.3	0.8	0.7	0.4	0.1	0.9	0.5
Mouth/teeth dental problems	0.4	0.6	1.1	0.9	0.7	1.0	0.8	0.6	1.0	0.9	0.8	0.4	0.8	0.8	0.5
Pain all over the body in last month	0.4	0.4	1.6	-0.5	-0.3	-0.2	-0.4	-0.9	0.0	-0.3	-0.5	-1.2	-1.3	-0.5	-0.1
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.1	-0.6	-0.8	-0.6	-0.9	-1.0	-0.9	-0.5	-0.4	-1.0	0.1	-0.3	-0.9
Medication: Cholesterol lowering	0.4	0.7	1.3	0.9	0.6	0.7	0.9	0.9	0.4	0.8	1.1	0.5	1.1	1.1	0.6
Medication: Lansoprazole	0.4	0.4	1.1	0.6	1.1	0.7	0.9	-0.2	0.9	0.3	0.4	0.6	0.7	0.6	0.2
Standing height	0.4	4.2	6.5	2.5	1.6	2.2	1.5	1.7	1.9	2.4	2.2	2.3	1.4	2.5	1.9
Forced vital capacity (FVC), Best measure	0.4	1.4	2.7	1.3	1.5	1.4	0.5	-0.0	0.5	1.6	1.6	1.0	0.3	1.3	1.7
Mean time to correctly identify matches	0.4	0.9	2.2	-1.1	-1.0	-1.0	-0.6	-0.4	-0.5	-1.2	-1.5	-0.3	-0.8	-1.2	-0.8
Comparative height size at age 10	0.4	2.4	4.6	1.9	0.6	1.3	1.1	1.9	0.8	1.6	2.0	1.4	2.1	2.1	0.6
Hypertension (Self-reported)	0.4	1.2	2.0	-1.2	-1.4	-1.4	-1.0	0.1	-1.4	-1.2	-1.2	-0.3	-0.1	-1.0	-1.4
Smoking status: Previous	0.4	0.6	3.5	-0.5	-1.1	-0.7	-1.1	-0.1	-1.9	-0.2	-0.2	0.4	-0.7	-0.1	0.0
Long-standing illness, disability or infirmity	0.4	0.7	1.5	0.7	0.6	0.7	1.2	-0.0	1.1	1.2	0.4	1.0	-0.1	0.6	1.0
Osteoporosis (self-reported)	0.4	0.5	2.2	0.6	-0.1	0.4	-0.0	1.5	-0.3	0.3	0.2	1.4	1.0	0.7	0.0
Ever depressed for a whole week	0.4	0.5	1.1	-0.6	-1.1	-1.0	-0.5	0.4	-1.0	-0.6	-0.5	-0.8	-0.2	-0.4	-0.8
Fasting Glucose	0.3	0.4	1.5	-0.6	-0.2	-0.7	-0.3	-1.0	-0.1	-0.2	-0.3	-1.2	-0.6	-0.4	-0.4
HbA1C	0.3	0.3	1.0	-0.5	-0.2	-0.4	0.0	0.0	-0.1	-1.0	-1.0	-0.0	0.4	-0.5	-1.0
HDL Cholesterol	0.3	0.6	2.1	-0.3	-1.0	-0.4	-1.1	-1.4	-0.8	-0.1	-0.0	-0.8	-1.0	-0.0	-0.2
Lupus	0.3	0.5	1.0	0.7	0.9	0.6	0.7	0.4	0.4	0.8	1.0	0.2	0.1	0.8	1.0
Neuroticism (2016)	0.3	0.4	1.3	0.5	0.6	0.4	0.6	0.2	1.1	0.6	0.0	1.1	-0.2	0.2	0.7
Height	0.3	6.0	10.8	2.6	2.1	2.6	1.5	3.1	1.3	2.8	2.5	3.3	1.2	2.5	2.8
Waist Hip Ratio (WHR)	0.3	1.4	2.5	1.6	0.9	1.1	0.1	0.9	0.7	1.6	1.4	1.4	-0.4	1.6	1.6
Frequency of depressed mood in last 2 weeks	0.3	0.4	1.7	0.2	0.6	0.1	-0.0	-1.3	0.9	0.4	-0.2	0.3	-1.1	-0.1	0.7
Vitamin and mineral supplements	0.3	0.4	1.2	-0.8	0.2	-0.5	0.0	-1.1	-0.1	-0.5	-0.5	-1.0	-0.6	-0.9	-0.1
Medication: Metformin	0.3	0.4	2.3	-0.2	-0.3	-0.2	-0.5	-0.2	-0.5	0.5	0.4	-0.6	-1.5	-0.2	0.9
Average weekly fortified wine intake	0.3	0.3	1.2	-0.5	-0.5	-0.5	-0.7	0.0	-1.1	-0.0	0.0	-0.8	-0.7	-0.4	0.2
High blood pressure	0.3	0.9	1.7	-1.0	-1.2	-1.2	-0.8	0.2	-1.2	-1.0	-0.9	-0.1	0.1	-0.8	-1.3
Supplements: Glucosamine	0.3	0.4	1.2	0.5	0.1	0.4	1.1	0.9	0.4	0.7	0.7	0.8	0.8	0.6	0.4
Number of incorrect matches in round	0.3	0.5	1.5	-0.5	-1.2	-0.8	-0.7	-0.7	-0.6	-0.6	-0.7	0.3	0.2	-0.5	-0.9
Heart attack	0.3	0.4	0.9	0.8	0.4	0.5	0.6	0.2	0.5	1.0	0.8	0.4	0.2	0.8	0.9
Weight	0.3	1.6	4.0	-1.1	-2.0	-1.5	-1.3	-1.2	-1.2	-1.2	-1.5	-0.3	-1.0	-1.1	-1.1
Worrier / anxious feelings	0.3	0.5	1.5	0.7	0.0	0.4	-0.5	-0.1	-0.2	1.0	0.8	1.0	-0.8	0.8	1.2
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	3.1	0.0	0.1	-0.0	-0.6	-1.1	0.2	0.4	-0.6	0.7	-1.8	-0.3	0.8
Pulse rate	0.3	0.5	1.4	0.9	0.4	0.7	0.4	-0.5	1.2	0.7	0.5	0.8	0.2	0.9	0.7
Length of working week for main job	0.3	0.4	0.7	0.7	0.7	0.7	0.4	0.2	0.7	0.8	0.8	0.3	0.4	0.6	0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	2.1	0.9	0.3	0.6	0.1	-0.1	0.7	0.5	0.3	1.4	-0.0	1.0	0.5
Medication: Amlodipine	0.3	0.4	1.4	-0.1	-0.3	0.1	-0.5	0.3	-0.9	0.6	0.4	0.3	-1.2	0.1	1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	1.1	0.8	-0.0	0.4	0.4	-0.5	0.5	1.0	0.8	0.7	0.3	0.8	0.6
Shortness of breath walking on level ground	0.3	0.4	0.9	-0.3	-0.8	-0.7	-0.2	0.9	-0.3	-0.6	-0.6	0.5	0.7	-0.5	-0.9
Emphysema/chronic bronchitis	0.3	0.4	1.5	0.1	0.5	0.2	0.1	-0.2	0.2	0.7	-0.3	1.0	-1.2	-0.2	1.0
Neck or shoulder pain in last month	0.3	0.4	0.8	-0.7	-0.9	-0.9	-0.0	0.4	-0.4	-0.8	-0.9	-0.2	0.0	-0.8	-0.9
Overall health rating	0.3	0.7	2.6	-0.8	-0.9	-0.8	-0.6	-0.8	-0.5	-0.3	-1.2	-0.1	-1.6	-0.9	-0.1
Loneliness, isolation	0.3	0.4	1.7	-0.3	0.6	-0.2	-1.0	-1.0	-0.2	-0.2	-0.4	-0.5	-1.3	-0.2	0.1
Commuting to job workplace: Walk	0.3	0.3	1.5	-0.0	0.3	0.0	1.1	-0.7	1.2	-0.4	-0.5	0.0	0.3	-0.2	-0.3
Illnesses of father: None of the above (group 1)	0.3	0.4	1.8	-0.3	0.5	-0.2	-0.2	-1.0	0.2	0.0	-0.2	-0.7	-1.3	-0.6	0.5
Miserableness	0.3	0.5	1.8	0.5	0.6	0.5	-0.2	-0.3	0.6	0.7	0.3	0.7	-1.4	0.3	1.2
Heart attack/myocardial infarction (self-reported)	0.3	0.3	0.8	0.7	0.3	0.5	0.5	0.1	0.5	0.9	0.7	0.3	0.1	0.7	0.9
Bipolar Disorder (2018)	0.2	0.3	1.1	0.3	-0.3	0.0	-0.5	0.5	-0.6	0.5	0.4	0.3	-1.0	0.3	0.8
Worry (Nagel 2018)	0.2	0.4	1.7	-0.2	-0.5	-0.6	-0.9	1.3	-0.7	-0.6	-0.5	0.2	0.2	-0.3	-0.8
Verbal and Numeric Reasoning (VNR)	0.2	0.4	1.1	0.3	0.8	0.1	1.0	-0.1	1.0	0.5	0.2	0.6	1.1	0.3	-0.1
LDL Cholesterol	0.2	0.4	1.1	-0.8	-0.0	-0.5	-0.1	-0.3	0.2	-0.9	-1.0	-0.4	0.2	-0.8	-1.1
Triglycerides	0.2	0.3	1.0	0.2	0.5	0.0	0.8	1.0	0.6	-0.1	-0.1	0.5	0.9	-0.2	-0.2
Number of treatments/medications taken	0.2	0.4	2.6	0.6	-0.3	0.2	0.2	0.0	0.1	0.7	0.2	1.6	0.3	0.8	0.4
Sensitivity / hurt feelings	0.2	0.4	2.5	0.2	-0.1	-0.1	-0.1	1.6	0.3	-0.1	-0.3	1.0	0.9	-0.1	-0.7
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	1.1	0.1	0.0	0.1	0.1	0.2	0.3	0.6	-0.2	0.7	-1.0	-0.2	0.8
Qualifications: CSEs or equivalent	0.2	0.3	0.6	0.6	0.0	0.4	-0.2	0.8	-0.0	0.8	0.7	0.4	-0.4	0.7	0.7
Serious illness, injury or assault to yourself	0.2	0.3	0.8	-0.5	-0.9	-0.6	0.1	0.1	-0.1	-0.6	-0.7	-0.2	-0.2	-0.6	-0.7
Medication: Atenolol	0.2	0.3	0.8	0.5	0.7	0.7	0.4	-0.1	0.1	0.7	0.7	0.2	-0.0	0.6	0.9
Forced vital capacity (FVC)	0.2	0.6	1.2	0.9	1.0	0.9	0.4	-0.4	0.5	1.0	1.1	0.5	0.4	1.0	0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	1.6	-0.3	-1.0	-0.4	-0.2	-0.2	-0.1	-0.9	-0.6	-0.2	1.0	-0.1	-1.3
Impedance of arm (right)	0.2	1.0	2.0	0.9	1.4	1.2	1.2	0.9	1.1	0.9	0.7	0.7	-0.0	0.6	1.4
Number of live births	0.2	0.2	0.8	-0.3	-0.3	-0.4	-0.2	0.9	-0.7	-0.5	-0.2	0.2	0.4	-0.4	-0.4
Qualifications: A levels/AS levels or equivalent	0.2	0.4	1.2	0.4	0.7	0.6	0.2	0.1	0.9	0.6	0.3	0.0	-1.1	0.1	1.0
Mouth/teeth dental problems: Dentures	0.2	0.3	0.8	-0.3	-0.7	-0.4	-0.9	-0.8	-0.6	-0.3	-0.3	-0.5	-0.7	-0.0	-0.3
Prospective memory result	0.2	0.3	1.0	-0.0	-0.9	-0.3	-1.0	0.5	-0.8	0.4	0.2	0.1	-0.8	0.0	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	1.8	0.6	1.2	0.9	0.1	-0.8	0.1	1.0	1.1	0.3	-0.3	0.7	1.4
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	1.8	0.2	0.1	-0.0	0.1	1.3	-0.2	0.2	0.1	1.1	0.0	-0.0	0.5
High blood pressure (siblings)	0.2	0.2	0.6	-0.3	-0.0	-0.4	0.2	0.8	0.0	-0.7	-0.3	-0.2	0.7	-0.4	-0.8
Comparative body size at age 10	0.2	0.4	1.3	-0.9	-0.1	-0.6	-0.4	0.2	-1.2	-0.7	-0.4	-0.8	-0.0	-0.9	-0.6
Worry too long after embarrassment	0.2	0.4	1.1	0.6	0.4	0.4	0.7	-0.4	0.8	0.8	0.5	1.1	-0.0	0.5	0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	1.0	-0.1	-0.8	-0.4	-1.0	-0.6	-0.6	-0.5	-0.5	0.1	-0.7	0.1	-0.5
Eye problems/disorders: None of the above	0.2	0.3	0.6	-0.4	-0.0	-0.3	0.0	-0.7	0.5	-0.5	-0.8	-0.7	-0.4	-0.6	-0.5
Pulse rate, automated reading	0.2	0.5	2.0	-0.5	-1.0	-0.7	-0.5	-1.4	0.2	-0.6	-1.0	-0.2	-0.6	-0.5	-0.6
Alcohol intake frequency.	0.2	0.4	1.6	-0.8	0.2	-0.2	-0.2	-0.5	-0.5	-0.5	-0.7	-1.3	-0.9	-0.6	-0.2
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	0.7	-0.5	-0.7	-0.4	-0.6	-0.1	-0.8	-0.6	-0.4	0.2	-0.6	-0.2	-0.3
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	1.0	0.1	0.5	0.4	0.7	0.3	0.2	-0.1	0.1	0.6	1.0	0.2	0.1
Supplements: Vitamin C	0.2	0.2	0.8	0.3	0.9	0.6	0.4	-0.3	0.8	0.1	-0.2	0.7	0.1	0.3	0.2
Illnesses of siblings: Diabetes	0.2	0.2	0.8	-0.3	-0.8	-0.3	0.1	-0.9	0.1	-0.2	-0.3	-0.4	-0.5	-0.4	-0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	1.2	-0.2	0.2	-0.2	0.1	-1.1	0.3	-0.5	-0.6	0.5	-0.3	-0.5	0.0
Eye problems/disorders: Cataract	0.2	0.2	0.7	-0.2	-0.7	-0.4	-0.6	-0.1	-0.7	0.0	-0.0	0.8	-0.2	-0.1	0.1
Medication: Gliclazide	0.2	0.2	1.0	0.3	-0.0	0.3	-0.2	-0.1	-0.3	0.6	0.4	0.0	-1.0	0.4	1.0
Guilty feelings	0.2	0.2	0.6	0.6	0.8	0.6	-0.4	0.2	0.3	0.7	0.4	0.4	-0.3	0.6	0.4
Ever taken oral contraceptive pill	0.2	0.2	0.7	-0.0	0.7	-0.1	0.9	-0.2	0.5	-0.2	-0.1	0.3	0.8	-0.3	0.1
Financial situation satisfaction	0.2	0.3	0.8	0.7	0.6	0.4	-0.0	-0.4	0.6	0.5	0.3	0.9	-0.1	0.8	0.4
Tinnitus: Yes, now most or all of the time	0.2	0.3	1.1	0.3	-0.5	-0.1	0.4	1.1	0.0	0.0	0.5	0.4	1.0	0.4	-0.4
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.5	0.5	0.4	0.5	0.3	-0.1	0.7	0.5	0.4	0.5	-0.0	0.4	0.7
Vascular/heart problems diagnosed by doctor	0.2	0.5	1.3	0.7	0.9	1.0	0.8	-0.3	1.1	0.7	0.7	-0.1	-0.1	0.5	0.9
Heart disease (siblings)	0.2	0.2	0.9	0.1	0.8	0.3	-0.1	-1.0	-0.1	0.4	-0.1	0.2	-0.6	0.3	0.6
Depressed Affect (Nagel 2018)	0.1	0.3	1.0	-0.2	-0.2	-0.5	-1.0	-0.3	-0.3	-0.4	-0.6	0.5	-0.8	-0.5	-0.0
Intelligence (Savage-Jansen 2018)	0.1	0.3	0.9	-0.3	0.3	-0.4	0.7	-0.9	0.6	-0.3	-0.5	-0.6	0.5	-0.2	-0.8
Neuroticism (Nagel 2018)	0.1	0.3	1.2	-0.2	-0.5	-0.6	-1.1	0.7	-0.6	-0.4	-0.6	0.5	-0.3	-0.4	-0.5
Alzheimer’s Disease (including proxy)	0.1	0.2	1.2	0.2	0.4	0.3	1.1	-0.1	0.6	0.2	0.1	0.4	0.5	0.1	0.3
Breast Cancer	0.1	0.3	1.2	-0.8	0.4	-0.3	-0.2	-0.3	-0.4	-0.3	-0.5	-0.4	-1.1	-0.9	0.4
Age at First Birth	0.1	0.1	0.5	-0.4	-0.5	-0.1	0.1	0.3	0.1	-0.7	-0.4	0.1	0.3	-0.3	-0.4
Crohns Disease (2012)	0.1	0.1	0.7	0.0	-0.4	-0.2	-0.1	0.8	0.2	-0.2	-0.2	0.1	-0.1	-0.3	-0.4
Mean Putamen Volume	0.1	0.2	0.6	0.1	0.8	0.6	0.3	0.1	0.5	0.2	0.3	0.0	-0.3	0.1	0.8
Blood Platelet Count	0.1	0.8	2.7	0.5	0.8	0.5	1.6	1.1	1.5	0.3	0.3	0.3	1.2	0.4	-0.1
Smoking Status	0.1	0.2	1.1	0.2	0.1	0.0	-0.0	-1.1	-0.5	0.5	0.4	0.5	-0.1	0.5	0.4
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.9	0.3	0.2	0.2	0.2	0.3	0.0	0.6	0.7	0.2	-0.3	0.2	0.9
Neuroticism	0.1	0.3	1.2	-0.3	-0.2	-0.4	-0.9	-0.3	-0.3	-0.2	-0.5	0.2	-1.1	-0.5	0.1
Hair Pigment	0.1	2.7	7.1	1.6	1.8	1.5	2.2	0.7	1.5	1.0	1.5	1.4	2.7	1.8	0.8
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.4	0.4	0.1	0.3	-0.1	0.4	0.0	-0.0	0.4	-0.5	0.6	0.6	-0.2
Medication: Co-codamol	0.1	0.1	0.2	-0.1	-0.1	-0.2	-0.4	0.3	-0.4	-0.1	0.1	-0.4	-0.3	-0.0	-0.1
Hand grip strength (right)	0.1	0.2	0.8	0.4	-0.6	0.0	0.1	0.5	0.2	-0.1	0.4	0.2	0.9	0.5	-0.4
Fed-up feelings	0.1	0.2	0.7	0.1	0.2	0.0	-0.6	-0.5	0.0	0.1	-0.4	0.8	-0.5	-0.0	0.2
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	1.0	0.3	0.2	0.1	0.5	0.1	0.3	0.2	0.1	0.1	1.0	0.4	-0.4
Sitting height	0.1	0.4	1.1	0.8	0.3	0.6	0.4	0.6	0.7	0.6	0.6	0.4	1.1	0.9	-0.0
Nervous feelings	0.1	0.1	0.4	-0.2	-0.2	-0.2	-0.1	0.6	-0.4	-0.1	-0.3	0.4	0.3	-0.1	-0.4
Hearing difficulty/problems with background noise	0.1	0.1	0.6	-0.3	-0.2	-0.3	-0.4	-0.1	-0.7	-0.1	-0.3	0.1	-0.8	-0.2	0.2
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.5	-0.4	-0.1	-0.4	-0.3	-0.4	-0.4	-0.1	-0.3	-0.4	-0.7	-0.3	0.0
Illnesses of siblings	0.1	0.1	0.6	0.3	0.2	0.3	0.1	0.8	0.2	0.4	0.3	0.3	0.5	0.2	0.1
Neuroticism score	0.1	0.2	0.8	-0.2	0.2	-0.2	-0.9	0.0	-0.2	-0.1	-0.4	0.3	-0.9	-0.3	0.1
Trunk fat-free mass	0.1	0.3	1.0	0.8	-0.4	0.2	-0.3	0.2	0.0	0.8	0.7	0.6	0.5	1.0	0.1
Father’s age at death	0.1	0.2	0.6	-0.3	-0.5	-0.4	-0.1	-0.5	-0.0	-0.4	-0.8	-0.0	-0.1	-0.1	-0.8
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.2	0.4	-0.4	0.0	-0.4	-0.4	-0.2	-0.6	0.1	-0.2	-0.3	-0.6	-0.5	0.1
Impedance of arm (left)	0.1	0.4	1.0	0.4	1.0	0.8	0.9	0.3	0.8	0.3	0.2	0.1	-0.4	0.1	1.0
Trunk predicted mass	0.1	0.3	1.1	0.8	-0.4	0.3	-0.3	0.2	0.1	0.8	0.7	0.6	0.5	1.1	0.1
Tense / ‘highly strung’	0.1	0.2	0.5	-0.3	0.1	-0.4	-0.7	-0.1	-0.1	-0.4	-0.7	-0.1	-0.2	-0.3	-0.7
Hair/balding pattern: Pattern 4	0.1	0.3	1.0	-0.8	0.0	-0.4	-0.1	-0.4	-1.0	-0.7	-0.3	-0.6	0.2	-0.7	-0.5
Qualifications: College or University degree	0.1	0.2	0.7	-0.3	-0.1	-0.3	-0.3	-0.7	-0.2	-0.1	-0.0	-0.9	-0.5	-0.3	-0.2
Medication for pain relief, constipation, heartburn	0.1	0.1	0.4	0.3	0.3	0.3	-0.1	0.7	0.3	0.2	0.4	0.0	0.1	0.3	0.0
Chest pain or discomfort	0.1	0.2	1.2	0.1	0.6	0.1	-0.2	-0.3	-0.2	0.2	0.1	-0.2	-1.1	0.3	0.7
Commuting to job workplace: Car/motor vehicle	0.1	0.2	0.9	0.0	0.0	0.2	-0.6	0.6	-0.9	0.1	0.3	0.1	-0.0	0.1	0.3
Illnesses of father: Heart disease	0.1	0.2	0.9	0.0	-0.2	0.0	0.6	0.7	0.2	-0.2	0.1	-0.3	1.0	0.3	-0.7
Leg fat-free mass (right)	0.1	0.3	1.1	0.1	-0.9	-0.3	-1.0	-0.3	-0.7	0.2	-0.0	0.2	-0.8	0.2	0.1
Mood swings	0.1	0.2	0.6	0.2	0.3	0.2	-0.7	-0.2	-0.2	0.2	0.1	0.8	-0.7	0.3	0.6
Mouth/teeth dental problems: Mouth ulcers	0.1	0.1	0.3	-0.4	-0.3	-0.4	-0.1	-0.4	-0.5	-0.4	-0.4	-0.1	0.1	-0.4	-0.4
Medication: Aspirin	0.1	0.2	0.4	-0.4	-0.5	-0.4	-0.0	-0.3	-0.5	-0.6	-0.4	-0.3	-0.0	-0.3	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	1.1	0.0	1.1	0.4	0.4	-0.0	0.3	-0.3	0.0	0.4	0.4	-0.1	0.1
Leg predicted mass (right)	0.1	0.3	1.2	0.0	-0.9	-0.3	-1.1	-0.4	-0.7	0.2	-0.0	0.2	-0.9	0.2	0.2
Average weekly champagne plus white wine intake	0.1	0.1	0.3	0.3	0.2	0.2	0.3	0.5	0.3	0.4	0.3	0.1	0.1	0.1	0.4
Hearing aid user	0.1	0.1	0.6	-0.1	-0.6	-0.3	-0.3	0.0	-0.3	0.1	0.0	0.2	-0.8	-0.1	0.2
Arm fat-free mass (left)	0.1	0.3	1.3	-0.0	-1.1	-0.5	-0.9	-0.4	-0.6	-0.0	-0.3	0.4	-0.1	0.1	-0.5
Pack years of smoking	0.1	0.1	0.3	0.3	0.1	0.3	0.2	0.3	0.4	0.5	0.1	0.4	-0.2	0.1	0.4
Impedance of whole body	0.1	0.7	1.9	0.7	1.3	1.0	1.4	0.4	1.2	0.5	0.4	0.6	0.4	0.4	0.9
Arm predicted mass (left)	0.1	0.3	1.3	0.1	-1.1	-0.5	-0.8	-0.3	-0.6	0.1	-0.1	0.4	0.0	0.3	-0.5
Crohns Disease (2017)	0.0	0.1	0.2	-0.0	0.2	-0.1	0.4	0.4	0.3	0.1	-0.1	0.2	-0.1	-0.4	0.1
Lung FVC	0.0	0.1	0.4	-0.2	0.6	-0.2	-0.3	-0.4	-0.4	-0.2	0.0	-0.0	0.0	-0.2	0.0
Tanning	0.0	0.2	1.0	0.1	0.6	0.3	0.2	0.4	1.0	-0.0	-0.5	0.7	-0.3	-0.4	0.2
Pack years adult smoking proportion	0.0	0.1	0.2	0.3	-0.1	0.2	0.1	0.4	0.3	0.4	0.1	0.3	-0.2	0.0	0.2
Leg fat-free mass (left)	0.0	0.2	0.8	0.1	-0.9	-0.3	-0.8	-0.1	-0.6	0.3	0.1	0.4	-0.6	0.3	0.1
Current tobacco smoking	0.0	0.0	0.2	-0.1	0.3	-0.0	0.1	-0.3	-0.2	0.2	-0.0	-0.3	-0.4	-0.1	0.1
Leg predicted mass (left)	0.0	0.2	0.7	0.2	-0.9	-0.2	-0.8	-0.1	-0.6	0.3	0.1	0.4	-0.6	0.3	0.2
Qualifications: None of the above	0.0	0.1	0.8	-0.1	-0.3	-0.1	-0.9	-0.2	-0.5	-0.0	-0.1	-0.2	-0.3	0.0	-0.1
Medication: Simvastatin	0.0	0.0	0.1	0.2	-0.0	0.1	-0.1	0.3	-0.1	0.1	0.1	0.1	-0.1	0.3	0.1
Forced expiratory volume in 1-second (FEV1)	0.0	0.1	0.6	0.0	0.4	0.2	-0.1	-0.8	-0.3	0.3	0.5	-0.2	-0.1	0.1	0.4
Arm fat-free mass (right)	0.0	0.2	0.6	0.5	-0.6	-0.0	-0.4	0.2	-0.2	0.5	0.4	0.8	0.4	0.7	-0.1
Arm predicted mass (right)	0.0	0.2	0.7	0.5	-0.6	-0.0	-0.3	0.2	-0.2	0.5	0.4	0.8	0.5	0.7	-0.0
Medication: Aspirin	0.0	0.1	0.3	-0.3	-0.1	-0.2	-0.0	-0.1	-0.6	-0.3	-0.1	-0.3	0.0	-0.2	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.0	0.1	0.4	0.3	0.1	0.2	-0.4	0.6	-0.2	-0.0	0.1	0.1	0.4	0.4	-0.4
Whole body fat-free mass	0.0	0.2	0.6	0.6	-0.6	0.1	-0.5	0.1	-0.2	0.6	0.5	0.6	0.1	0.8	0.1
Smoking status: Current	0.0	0.1	0.2	-0.0	0.4	0.0	0.2	-0.3	-0.0	0.3	0.1	-0.1	-0.5	-0.1	0.3
Whole body water mass	0.0	0.2	0.5	0.5	-0.7	-0.0	-0.7	0.1	-0.3	0.6	0.4	0.6	-0.0	0.7	0.1
Basal metabolic rate	0.0	0.3	1.1	0.0	-1.1	-0.4	-0.9	-0.4	-0.6	0.1	-0.1	0.3	-0.4	0.2	-0.2

Hub : Genes

TSLP

Models

Trait associations