Hub : Genes

CAMK4

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 METSIM Adipose 0.0498 0.0237 4.2e-03 0.013 0.025 0.020 0.026 0.010 4.5e-03 9.5e-05 4.9e-04 8.3e-05 9.1e-03
2 ROSMAP Brain Pre-frontal Cortex 0.0979 0.0271 5.7e-06 0.034 0.035 0.029 0.036 0.039 2.9e-05 2.0e-05 1.2e-04 1.6e-05 7.8e-06
3 TCGA Bladder Urothelial Carcinoma 0.0440 0.0230 8.4e-03 0.039 0.011 -0.003 NA 0.007 3.0e-04 3.6e-02 6.4e-01 NA 8.0e-02
4 TCGA Pancreatic Adenocarcinoma 0.1560 0.0610 1.9e-03 -0.002 0.048 0.018 NA 0.013 4.1e-01 4.3e-03 5.5e-02 NA 8.6e-02
5 TCGA Prostate Adenocarcinoma 0.1373 0.0426 2.1e-07 0.072 0.065 0.040 NA 0.067 5.5e-08 2.4e-07 4.4e-05 NA 1.5e-07

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 1.0 1.6 5.7 0.3 -0.3 -0.3 -1.4 -2.4
Bipolar Disorder or Schizophrenia 1.0 2.5 7.3 1.6 -1.4 0.6 0.5 -2.7
Depressed Affect (Nagel 2018) 1.4 2.9 10.7 1.4 1.0 0.9 3.3 -0.1
Depression (Nagel 2018) 1.0 1.6 2.6 -0.2 1.3 0.9 1.6 1.6
Intelligence (Savage-Jansen 2018) 0.9 2.7 7.0 0.1 -0.4 -2.1 1.4 2.6
Neuroticism (Nagel 2018) 1.3 3.1 10.5 2.0 0.3 0.8 3.2 -0.7
Schizophrenia (2018) 1.2 2.5 3.5 1.9 -1.6 0.9 1.8 -1.5
Schizophrenia vs Biploar Disorder 0.8 1.1 3.0 -0.1 0.6 0.1 1.7 1.4
Worry (Nagel 2018) 1.5 3.1 11.0 1.7 0.1 1.3 3.3 -0.1
Alzheimer’s Disease (in mother) 1.4 1.6 2.5 0.8 -1.0 -1.2 -1.6 -1.5
Alzheimer’s Disease (in father) 0.8 0.9 1.7 -1.3 0.9 -0.4 -1.3 0.2
Alzheimer’s Disease (including proxy) 0.2 0.2 0.6 0.3 -0.3 -0.8 -0.4 -0.5
Crohns Disease (2017) 0.1 0.2 0.7 0.2 0.0 0.3 0.2 -0.8
Irritable Bowel Disease (IBD) 0.5 1.1 3.2 1.8 -1.1 0.7 0.2 -0.8
Ulcerative Colitis (UC) 1.0 1.9 5.2 2.3 -1.4 1.3 0.3 -0.8
Major Depression (MDD) 0.9 1.1 2.3 0.2 0.4 1.5 1.5 0.7
Reaction Time 0.9 1.7 4.1 -2.0 1.8 -0.0 -1.0 0.6
Verbal and Numeric Reasoning (VNR) 0.7 1.8 4.7 1.1 -0.8 -0.9 2.2 1.3
Breast Cancer 0.9 2.2 6.9 -1.4 1.3 0.6 -0.7 2.6
Ovarian Cancer 0.5 0.6 1.4 -0.0 0.5 1.2 1.1 -0.4
Prostate Cancer 0.5 0.7 1.7 0.1 -1.3 1.1 -0.4 -0.5
Age at First Birth 0.3 0.5 1.5 0.1 -1.2 0.7 0.4 0.3
Bipolar Disorder (2011) 1.6 1.5 4.8 1.5 -0.7 -0.3 0.3 -2.2
Body Mass Index (BMI) (2010) 1.5 2.0 5.1 -2.3 1.5 -0.8 0.4 1.5
Coronary Artery Disease (CAD) 0.4 0.5 1.1 0.7 -0.3 -1.1 -0.3 0.7
Crohns Disease (2012) 0.5 0.8 2.8 -0.6 -0.1 -0.8 -1.7 0.6
Mean Putamen Volume 0.3 0.3 1.1 -0.6 1.0 0.1 -0.5 0.0
Fasting Glucose 1.6 1.9 4.0 -0.6 1.3 1.8 -0.4 2.0
HbA1C 0.4 0.5 1.0 -1.0 1.0 -0.2 0.4 0.3
HDL Cholesterol 0.6 0.9 3.9 -0.9 -0.2 -2.0 -0.2 0.0
LDL Cholesterol 0.8 1.3 2.3 -0.3 1.2 0.7 1.4 1.5
Lupus 0.9 1.3 2.4 1.6 -1.0 1.2 1.1 -0.8
Neuroticism (2016) 0.8 1.1 4.0 2.0 -0.6 0.4 0.3 -1.0
Primary Biliary Cirrhosis 0.6 0.9 3.5 -1.9 0.1 -0.8 -0.5 0.5
Rheumatoid Arthritis 0.8 1.2 2.3 0.3 -0.6 1.1 1.3 -1.5
Schizophrenia (2014) 0.7 1.6 3.5 1.6 -1.9 0.4 1.2 -0.7
Triglycerides 0.1 0.2 0.8 -0.4 0.9 -0.2 -0.1 0.3
Type 2 Diabetes (T2D) (2012) 0.7 0.8 2.2 -1.5 0.9 0.5 -0.7 0.3
Ulcerative Colitis 0.4 0.6 1.5 1.2 -1.1 0.4 -0.5 0.1
Blood Eosinophil Count 7.8 59.9 134.6 8.8 -11.6 -8.5 -1.9 -3.4
Blood Platelet Count 0.1 1.1 2.9 1.7 -0.6 -0.4 1.3 0.5
Blood Red Count 0.2 2.3 5.9 -1.3 0.1 -0.1 -2.4 2.0
Blood White Count 0.3 1.9 4.6 2.1 -1.8 -1.1 -0.1 0.9
Heel T-Score 0.2 1.2 4.2 -2.0 1.2 -0.2 -0.1 -0.6
BMI 0.7 4.0 16.0 -4.0 0.9 -0.9 -1.6 0.0
Height 0.2 3.1 6.9 2.6 -2.0 2.0 -0.8 0.3
Waist Hip Ratio (WHR) 0.4 2.0 5.2 2.3 -1.5 -0.3 0.8 -1.4
Systolic Blood Pressure 0.1 0.5 0.9 -0.1 0.9 0.5 0.8 0.8
Smoking Status 0.2 0.4 1.0 1.0 -0.7 -0.3 0.5 0.3
Allergy or Eczema 19.1 50.3 108.2 10.4 -10.1 -6.4 0.7 -0.2
Cardiovascular Disease 0.0 0.1 0.3 -0.4 0.4 0.0 0.2 0.6
Hypothyroidism (self reported) 1.5 3.4 12.2 -1.2 -0.9 -1.5 -3.5 -0.6
Respiratory disease 7.9 17.6 46.6 6.8 -5.4 -3.5 0.4 -0.3
Type 2 Diabetes (T2D) (2018) 0.2 0.4 1.2 -0.7 -0.2 -0.3 0.1 1.1
Lung FEV1/FVC ratio 0.8 4.1 9.5 -1.3 0.2 -3.1 -2.3 -2.0
Lung FVC 0.2 1.1 2.3 -0.2 0.4 1.1 1.5 1.4
Neuroticism 0.9 2.1 5.7 1.9 0.8 0.8 2.4 -0.4
Chronotype (morning person) 3.0 6.9 13.5 -3.7 1.7 -1.7 -1.7 3.5
Hair Pigment 0.0 0.8 2.4 1.0 -0.9 -0.1 0.1 -1.5
Tanning 0.0 0.3 0.7 -0.0 0.8 0.6 0.6 -0.3
Hand grip strength (left) 0.3 0.9 2.2 0.3 -1.5 1.0 -0.6 -0.9
Number of treatments/medications taken 0.4 0.7 1.4 0.9 0.2 -1.2 -0.8 0.8
Average weekly spirits intake 1.7 2.1 9.0 -3.0 0.9 0.3 -0.2 0.7
Sensitivity / hurt feelings 1.0 1.7 3.0 0.7 1.7 1.6 1.4 -0.3
Frequency of depressed mood in last 2 weeks 0.8 1.2 4.0 0.9 0.7 0.3 2.0 0.7
Hearing difficulty/problems: Yes 1.0 1.5 6.4 -0.1 -0.8 -2.5 -0.0 -0.7
Relative age of first facial hair 0.4 0.7 2.1 0.3 -1.4 1.0 -0.6 -0.3
Other serious medical condition/disability diagnosed by doctor 1.6 2.1 5.0 -0.5 2.2 1.1 -0.3 1.9
Ever used hormone-replacement therapy (HRT) 1.3 1.7 3.7 -1.0 1.9 0.3 1.3 1.4
Ever had hysterectomy (womb removed) 1.6 1.8 3.8 1.2 0.5 1.8 2.0 0.2
Systolic blood pressure, automated reading 1.3 3.9 7.6 -2.1 2.4 0.6 1.1 2.8
Eye problems/disorders: Diabetes related eye disease 0.7 0.7 2.3 -0.2 0.1 -1.5 1.1 0.3
Angina 0.7 1.0 2.3 -0.0 -1.0 -0.9 -0.9 -1.5
Medication for hormone replacement therapy 0.8 0.9 2.0 -1.4 1.2 -0.1 0.3 1.1
Vitamin and mineral supplements 0.6 0.8 1.5 -1.1 0.5 0.9 -0.5 1.2
Supplements: Zinc 1.8 2.0 5.3 1.4 -0.3 -0.1 1.6 -2.3
Medication: Co-codamol 0.5 0.6 1.9 -0.5 -0.4 -1.4 -0.6 0.7
Medication: Metformin 0.2 0.2 0.4 -0.5 0.6 0.6 0.1 0.2
Diabetes (father) 1.1 1.4 4.6 0.3 -1.1 -2.1 -0.2 1.0
Diabetes (mother) 1.6 2.1 3.6 -1.9 1.9 1.7 0.3 0.6
Severe depression (siblings) 0.6 0.7 2.8 -0.1 1.7 0.8 0.5 0.0
Pack years adult smoking proportion 1.4 2.1 4.0 -0.6 0.0 -1.7 -2.0 1.8
Impedance of leg (right) 0.3 1.7 7.5 2.7 -0.6 0.0 -0.6 0.1
Leg fat-free mass (left) 0.1 0.7 1.3 -0.9 -0.5 1.2 -0.6 -0.7
Trunk fat percentage 0.2 0.7 1.7 -1.2 -0.1 -0.1 -1.3 -0.1
Hand grip strength (right) 0.2 0.5 1.4 -0.4 -0.9 1.2 -0.3 -0.4
Townsend deprivation index at recruitment 0.8 1.1 2.9 -0.9 1.7 0.6 -1.1 -0.2
Current tobacco smoking 0.2 0.4 1.3 1.1 -0.3 0.5 -0.1 0.4
Average weekly fortified wine intake 0.6 0.7 2.0 -0.8 -0.1 0.6 -1.4 -0.7
Maternal smoking around birth 0.6 0.9 1.9 -1.0 0.9 1.4 -0.9 0.3
Fed-up feelings 1.2 2.1 4.6 1.1 1.8 2.1 1.2 -0.0
Frequency of unenthusiasm / disinterest in last 2 weeks 2.6 3.5 8.1 -1.3 2.8 1.4 1.3 2.0
Relative age voice broke 0.7 1.1 2.1 0.2 -0.9 0.7 -1.4 -1.5
Taking other prescription medications 1.5 2.3 6.8 2.6 -0.6 -1.4 -1.5 -0.1
Age when periods started (menarche) 3.1 7.4 13.2 -2.9 3.6 1.1 -2.8 2.5
Bilateral oophorectomy (both ovaries removed) 0.2 0.2 0.6 0.3 -0.1 -0.2 0.5 0.8
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.4 0.6 -0.5 -0.8 -0.0 0.8 -0.8
Tinnitus: Yes, but not now, but have in the past 1.4 1.4 3.6 -1.9 1.4 -0.6 -1.1 -0.4
Qualifications: CSEs or equivalent 0.9 1.2 2.7 1.6 -0.2 0.8 -0.1 -1.6
Serious illness, injury or assault to yourself 0.5 0.6 1.9 -0.2 1.4 0.3 -0.4 1.0
High blood pressure 0.2 0.6 1.5 0.1 1.2 -0.4 1.2 0.3
Hayfever, allergic rhinitis or eczema 19.8 43.1 87.6 9.2 -9.4 -6.5 0.4 -0.5
Multivitamins +/- minerals 0.6 0.8 3.2 0.5 -0.3 -1.8 -0.2 -0.6
Stomach or abdominal pain in last month 2.0 2.5 7.3 -0.8 1.7 0.4 -1.3 2.7
Supplements: Glucosamine 0.2 0.3 0.9 0.2 0.5 0.4 0.4 -0.9
Diverticular disease/diverticulitis (self-reported) 2.2 2.6 3.2 -1.7 1.6 1.5 1.5 1.8
Medication: Atenolol 0.2 0.3 1.1 0.1 0.5 -0.1 -1.1 -0.4
Medication: Levothyroxine sodium 0.9 1.5 3.9 -0.6 0.3 -1.3 -2.0 -1.3
Sitting height 0.1 0.6 0.8 0.5 -0.9 0.8 -0.8 0.8
Chronic bronchitis/emphysema (father) 0.2 0.3 0.8 0.3 -0.4 0.4 -0.9 -0.3
High blood pressure (mother) 1.3 1.8 3.5 -1.5 1.9 0.6 -1.5 0.8
Body mass index (BMI) 0.4 1.6 7.5 -2.7 0.6 0.2 -0.5 -0.3
Impedance of leg (left) 0.3 1.6 7.0 2.6 -0.8 -0.0 -0.5 0.5
Leg predicted mass (left) 0.1 0.7 1.4 -0.8 -0.5 1.2 -0.6 -0.8
Trunk fat mass 0.1 0.6 1.4 -1.2 -0.3 0.5 -1.2 -0.1
Waist circumference 0.1 0.3 0.7 -0.8 -0.6 0.4 0.3 -0.7
Number of incorrect matches in round 0.5 0.9 3.0 -0.1 -1.7 0.1 -0.1 1.2
Past tobacco smoking 0.5 0.9 1.6 -0.4 1.1 1.3 0.2 1.2
Alcohol usually taken with meals 1.0 1.6 3.1 -1.8 1.6 -0.9 -0.3 1.2
Nervous feelings 0.9 1.7 5.1 0.8 0.8 0.9 2.3 1.2
Frequency of tenseness / restlessness in last 2 weeks 0.6 0.9 3.1 -0.2 1.8 0.2 0.6 1.0
Hearing difficulty/problems with background noise 0.7 1.2 1.8 -1.2 1.2 -1.3 -0.1 1.0
Hair/balding pattern: Pattern 2 0.3 0.3 1.4 0.3 -0.4 1.2 -0.2 0.3
Had menopause 1.4 1.8 5.0 -0.7 2.2 0.8 1.1 1.1
Had other major operations 1.3 1.5 4.6 -1.0 1.0 1.0 -2.2 0.3
Forced vital capacity (FVC) 0.2 0.7 2.8 0.1 -0.7 0.5 -0.3 1.7
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.7 1.8 -0.3 -0.7 0.2 1.1 -1.3
Ever unenthusiastic/disinterested for a whole week 1.0 1.3 3.2 -0.7 -0.2 -1.6 -1.8 -0.1
Qualifications: None of the above 0.5 1.1 5.3 0.1 -0.1 2.3 -0.2 -0.3
Financial difficulties in last 2 years 1.0 1.3 2.3 1.5 -1.5 0.2 1.0 -0.9
Mouth/teeth dental problems 0.5 0.7 3.3 0.0 -0.4 -0.3 -0.2 1.8
Heart attack 1.2 1.6 5.5 0.7 0.6 -1.1 -0.6 -2.3
Allergy 22.2 51.0 110.2 -9.6 10.5 7.2 0.0 0.6
Pain all over the body in last month 2.5 2.7 3.9 -2.0 1.7 1.7 -1.6 1.2
Diabetes (self-reported) 0.1 0.2 0.7 -0.4 0.3 0.3 0.9 0.2
Hayfever/allergic rhinitis (self-reported) 13.7 18.2 41.1 5.5 -6.4 -4.1 0.6 -1.5
Medication: Ramipril 0.6 0.8 1.4 1.2 1.1 -0.5 -0.6 0.9
Medication: Simvastatin 0.1 0.1 0.2 0.2 -0.5 0.4 -0.3 -0.1
Fluid intelligence score 1.0 2.1 4.2 1.6 -1.2 -0.5 2.0 1.5
Illnesses of siblings 1.5 2.1 8.5 0.8 -0.9 2.9 -0.7 0.2
Neuroticism score 1.1 2.3 8.1 0.9 1.4 0.6 2.8 0.7
Weight 0.2 0.8 2.2 -1.5 -0.2 1.1 -0.6 -0.3
Impedance of arm (right) 0.6 2.9 6.2 2.5 -1.2 -2.3 -1.3 -0.1
Arm fat percentage (right) 0.4 1.5 4.8 -2.2 0.3 -0.7 -1.3 -0.5
Trunk fat-free mass 0.2 0.9 3.9 -0.3 -0.6 2.0 0.3 -0.3
Hip circumference 0.4 1.9 8.4 -2.9 0.9 0.6 -0.1 0.3
Time employed in main current job 0.6 0.7 1.9 0.4 -0.0 -1.4 0.9 0.8
Alcohol intake versus 10 years previously 0.9 1.3 2.4 1.2 -0.7 1.6 1.4 0.2
Father’s age at death 2.2 2.9 12.9 -0.3 -0.2 0.5 1.1 3.6
Worrier / anxious feelings 0.8 1.5 3.6 1.0 -1.2 -0.3 1.9 -1.1
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.6 2.3 0.8 0.2 -0.0 -0.0 -1.5
Falls in the last year 1.1 1.5 4.8 -0.7 2.2 -0.3 -1.2 0.9
Hair/balding pattern: Pattern 3 0.5 0.7 1.7 1.3 -0.7 0.4 -0.1 -1.0
Number of live births 0.8 1.2 3.6 0.3 -1.0 1.0 -1.9 0.3
Forced expiratory volume in 1-second (FEV1) 0.1 0.4 0.7 -0.4 -0.6 -0.4 -0.8 0.6
Pulse rate 0.2 0.4 1.0 0.4 -1.0 0.7 0.3 0.2
Happiness 0.2 0.3 0.6 -0.0 -0.7 -0.8 0.0 0.5
Noisy workplace 1.2 1.5 3.7 -1.9 1.9 -0.3 0.3 -0.4
Qualifications: A levels/AS levels or equivalent 0.8 1.7 5.4 -0.2 -1.3 -2.3 -0.2 1.2
Serious illness, injury or assault of a close relative in last 2 years 0.6 0.6 1.6 -1.0 0.2 -1.3 0.5 -0.6
Mouth/teeth dental problems: Dentures 0.5 0.9 1.9 -0.9 0.6 0.8 -0.8 -1.4
Asthma 10.7 21.2 48.6 7.0 -6.3 -3.9 1.0 -1.3
Medication: Ibuprofen (e.g. Nurofen) 1.5 1.9 7.1 0.7 0.1 2.7 0.8 1.0
Medication: Cholesterol lowering 0.6 0.9 3.0 0.8 -1.0 0.1 -0.1 -1.7
Depression (self-reported) 1.7 2.0 6.9 2.6 -0.5 1.3 1.0 0.0
Medication: Lansoprazole 2.7 3.1 12.0 1.8 -0.1 0.5 3.5 0.0
Prospective memory result 0.5 0.6 2.0 -1.4 -0.0 -0.8 -0.2 0.4
Lung cancer (father) 0.5 0.5 1.7 -0.1 1.3 0.8 0.6 0.3
Illnesses of mother 0.3 0.4 1.0 0.2 -0.7 0.2 1.0 -0.7
Forced expiratory volume in 1-second (FEV1), Best measure 0.0 0.1 0.5 -0.4 -0.7 -0.2 -0.0 0.0
Pulse wave Arterial Stiffness index 1.3 1.5 6.6 -2.6 0.3 -0.4 -0.8 -0.4
Impedance of arm (left) 0.3 1.3 3.0 1.7 -0.8 -1.2 -1.0 0.2
Arm fat mass (right) 0.2 0.9 3.5 -1.9 0.0 0.3 -1.0 -0.4
Trunk predicted mass 0.2 1.0 4.1 -0.3 -0.7 2.0 0.3 -0.3
Standing height 0.2 2.4 5.8 2.4 -1.6 1.8 -0.3 0.3
Length of working week for main job 0.8 0.8 2.9 0.1 -0.5 -1.0 -0.0 -1.7
Exposure to tobacco smoke at home 0.4 0.4 1.7 -0.6 -0.2 -0.0 -0.2 -1.3
Breastfed as a baby 0.2 0.3 0.7 -0.3 0.9 -0.2 0.6 0.4
Tense / ‘highly strung’ 0.7 1.2 4.4 0.7 0.9 0.2 2.1 0.5
Seen doctor (GP) for nerves, anxiety, tension or depression 0.7 1.0 2.6 1.6 -1.0 -0.4 1.1 0.5
Hair/balding pattern: Pattern 4 1.0 2.5 5.1 -2.2 2.3 -0.2 0.2 1.5
Birth weight of first child 0.3 0.5 1.1 0.8 -0.3 0.4 0.8 1.1
Peak expiratory flow (PEF) 1.8 4.2 11.9 1.1 -3.5 -2.1 -1.3 -1.3
Pulse wave reflection index 0.2 0.3 0.5 -0.7 0.2 -0.3 -0.5 -0.7
Ever highly irritable/argumentative for 2 days 0.9 1.0 2.3 0.6 0.9 1.5 0.6 1.1
Loud music exposure frequency 0.9 0.9 1.7 1.1 0.1 -1.3 -1.0 -0.8
Qualifications: O levels/GCSEs or equivalent 0.2 0.2 0.5 0.6 -0.4 -0.7 0.2 -0.2
Mouth/teeth dental problems: Bleeding gums 0.4 0.5 1.2 0.6 -0.0 -0.8 1.1 -0.2
Blood clot in the leg (DVT) 1.5 1.9 3.0 1.1 -1.7 -1.7 -1.4 0.7
Medication: Paracetamol 0.5 0.8 2.7 -0.4 1.0 0.5 0.4 1.6
Headache pain in last month 0.8 1.4 2.8 -0.6 1.7 1.3 1.4 0.4
Medication for cholesterol, blood pressure or diabetes 0.7 1.2 2.2 -1.5 0.4 1.1 -0.9 1.2
Glaucoma (self-reported) 1.6 1.9 5.7 -0.9 -0.1 1.5 2.4 0.7
Gout (self-reported) 0.5 0.7 1.4 0.9 0.1 0.5 1.2 0.9
Hypothyroidism/myxoedema (self-reported) 1.5 3.0 11.0 -1.1 -0.3 -1.2 -3.3 -1.2
Medication: Amlodipine 0.6 0.8 3.5 0.1 -0.3 -1.9 -0.3 0.7
Medication: Ventolin 100micrograms inhaler 2.7 3.4 8.8 3.0 -2.3 0.6 1.4 -0.8
Birth weight 0.3 0.7 2.8 1.7 -0.2 -0.2 0.1 -0.7
Chronic bronchitis/emphysema (mother) 0.2 0.3 0.6 0.3 -0.4 -0.7 -0.3 -0.7
High blood pressure (siblings) 1.6 2.4 11.0 -0.3 0.7 -3.3 0.3 0.4
Forced vital capacity (FVC), Best measure 0.2 0.7 1.7 0.3 -0.9 0.8 0.4 1.3
Body fat percentage 0.2 0.7 2.0 -1.4 -0.0 0.0 -1.3 -0.3
Leg fat percentage (right) 0.2 0.8 1.8 -1.4 -0.2 0.6 -1.0 -0.8
Arm fat-free mass (right) 0.2 1.3 5.6 -0.7 -0.5 2.4 -0.0 -0.1
Exposure to tobacco smoke outside home 1.0 1.3 2.5 -1.3 1.6 -0.0 1.3 0.7
Comparative body size at age 10 0.8 2.2 5.6 0.4 -0.1 2.4 2.2 -0.7
Number of full brothers 0.5 0.6 1.7 -1.3 -0.5 0.3 -0.9 0.6
Worry too long after embarrassment 0.7 1.2 4.8 0.1 -0.7 -2.2 0.7 0.7
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.7 2.2 0.9 -0.3 0.7 1.5 -0.4
Wheeze or whistling in the chest in last year 3.6 6.4 15.6 4.0 -2.8 -2.7 0.8 -0.5
Number of children fathered 1.1 1.2 4.0 -0.3 0.4 2.0 0.9 -0.9
Reason for reducing amount of alcohol drunk: Health precaution 2.0 2.3 4.1 1.0 -2.0 -1.9 -0.4 -1.6
Age at first live birth 1.0 1.8 2.8 1.7 -1.4 -1.0 1.5 -1.0
Pulse wave peak to peak time 1.5 1.7 7.3 2.7 -0.3 0.6 0.9 0.3
Health satisfaction 0.2 0.2 0.6 -0.5 0.1 -0.3 0.7 -0.3
Shortness of breath walking on level ground 0.8 0.9 2.0 -0.4 1.0 0.7 0.9 -1.4
Qualifications: College or University degree 1.1 3.4 12.0 -0.5 -1.3 -3.5 0.5 1.7
Eye problems/disorders: None of the above 0.2 0.3 0.6 -0.2 0.8 -0.7 -0.4 0.4
Mouth/teeth dental problems: Loose teeth 0.5 0.6 1.6 -0.4 0.3 -0.1 0.9 1.3
Emphysema/chronic bronchitis 0.7 0.8 2.3 -0.2 0.1 -1.1 -1.5 -0.7
Medication for pain relief, constipation, heartburn 0.2 0.4 1.2 0.0 -0.4 -1.1 0.6 -0.6
Neck or shoulder pain in last month 0.3 0.5 2.2 0.1 0.0 -0.2 -0.4 -1.5
Medication: Blood pressure 1.1 2.0 4.7 2.2 -0.2 -1.5 1.3 -1.1
Angina (self-reported) 0.7 0.9 1.9 0.1 -1.0 -0.8 -1.1 -1.4
Migraine (self-reported) 0.1 0.2 0.5 0.7 -0.4 -0.1 -0.3 0.3
Medication: Ibuprofen 0.7 0.8 3.3 0.1 0.3 1.8 0.1 0.8
Medication: Allopurinol 0.1 0.2 0.5 0.2 -0.7 -0.3 0.2 0.5
Medication: Omeprazole 0.9 1.1 2.4 -1.0 0.5 1.1 -1.6 -0.6
Medication: Seretide 50 evohaler 2.9 3.3 6.1 1.6 -2.2 -2.5 -1.8 -0.2
Mean time to correctly identify matches 0.9 1.7 4.5 -1.6 2.1 0.8 -0.6 0.8
Heart disease (mother) 0.3 0.4 0.7 -0.8 0.2 -0.7 0.8 0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 2.5 2.9 7.6 -2.5 0.6 -0.2 -2.8 -0.6
Whole body fat mass 0.2 0.8 2.1 -1.4 -0.0 0.5 -1.3 -0.1
Leg fat mass (right) 0.2 0.8 1.5 -1.2 -0.4 0.8 -1.0 -0.7
Arm predicted mass (right) 0.3 1.5 7.0 -0.6 -0.5 2.6 -0.2 -0.2
Pulse rate, automated reading 0.3 0.9 2.8 0.7 -0.0 1.7 1.1 -0.2
Alcohol intake frequency. 0.7 1.6 2.5 -1.2 1.6 1.5 0.6 1.2
Comparative height size at age 10 0.2 0.9 1.9 1.3 -1.4 0.6 0.6 0.7
Number of full sisters 2.7 3.3 9.4 -2.4 3.1 0.7 -0.9 -0.4
Suffer from ‘nerves’ 2.6 4.1 12.4 0.7 0.6 2.5 3.5 0.9
Overall health rating 0.4 0.9 3.9 0.1 2.0 0.2 0.5 -0.3
Chest pain or discomfort 0.2 0.2 0.8 -0.1 -0.1 -0.9 -0.6 -0.2
Had major operations 1.0 1.2 3.1 -0.8 -0.7 -1.3 -0.4 -1.8
Age at last live birth 0.4 0.6 1.0 1.0 -0.5 0.5 0.9 -0.8
Family relationship satisfaction 0.1 0.2 0.3 -0.5 -0.4 0.4 0.1 -0.5
Leg pain on walking 1.3 1.6 4.3 -1.2 2.1 -0.0 -0.2 1.5
Qualifications: NVQ or HND or HNC or equivalent 0.8 1.0 3.6 0.2 0.9 -0.4 0.7 -1.9
Commuting to job workplace: Car/motor vehicle 1.5 1.7 2.4 1.5 -1.4 1.5 0.5 -1.3
Illness, injury, bereavement, stress in last 2 years 0.5 0.7 2.6 0.3 -0.3 0.7 -1.6 0.2
Medication: Aspirin 0.1 0.1 0.2 -0.4 0.2 -0.4 -0.1 -0.5
Supplements: Vitamin C 1.1 1.3 2.2 1.5 0.5 1.3 1.2 -1.0
Knee pain experienced in last month 2.1 3.3 7.0 -1.0 2.0 2.1 2.6 0.5
Hypertension (Self-reported) 0.3 0.8 2.3 -0.2 1.5 -0.4 1.2 0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.0 0.0 0.2 -0.1 0.0 -0.2 -0.4 0.0
Illnesses of father: Heart disease 0.4 0.5 1.4 0.7 -0.3 -0.7 1.2 -0.4
Illnesses of siblings: Diabetes 0.3 0.4 1.6 -0.2 0.5 0.2 1.3 -0.2
Smoking status: Previous 0.5 0.7 1.6 0.3 -0.6 -1.3 -0.1 -1.2
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.9 3.4 0.8 0.5 1.9 0.1 -0.1
Whole body fat-free mass 0.1 0.8 3.3 -0.4 -0.6 1.8 -0.2 -0.4
Leg fat-free mass (right) 0.1 0.6 1.3 -0.9 -0.5 1.1 -0.5 -0.5
Arm fat percentage (left) 0.4 1.5 6.0 -2.4 0.1 -0.3 -1.2 -0.3
Average weekly red wine intake 1.0 1.5 2.2 -1.5 0.3 -1.3 -1.4 1.2
Handedness (chirality/laterality): Left-handed 1.5 1.8 4.8 1.9 -2.2 -0.2 -0.3 -0.7
Mood swings 1.2 2.2 8.7 1.3 0.5 0.8 3.0 0.1
Loneliness, isolation 0.9 1.2 3.5 0.9 0.5 0.6 1.9 1.2
Long-standing illness, disability or infirmity 1.9 3.0 10.3 -1.2 3.2 -1.3 -1.1 0.6
Ever had bowel cancer screening 0.6 0.7 1.9 -1.2 0.5 0.2 0.3 1.4
Diabetes diagnosed by doctor 0.2 0.3 0.7 -0.8 0.5 0.1 0.5 0.6
Ever had stillbirth, spontaneous miscarriage or termination 0.8 0.8 2.3 -1.1 -0.1 1.5 -0.8 0.5
Friendships satisfaction 0.1 0.2 0.6 -0.3 -0.0 -0.1 0.8 -0.5
Qualifications: nursing, teaching 0.4 0.7 2.1 -0.3 1.0 -1.4 0.3 0.3
Commuting to job workplace: Walk 1.2 1.3 2.1 -1.0 1.5 -0.8 -0.8 1.5
Eye problems/disorders: Cataract 0.7 0.8 2.2 1.0 -1.5 0.5 -0.3 -0.5
Mouth/teeth dental problems: Mouth ulcers 1.4 2.2 5.2 1.9 -1.3 0.1 0.7 -2.3
Medication for cholesterol 1.1 1.7 3.4 1.4 -1.8 -0.4 -0.9 -1.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.4 1.7 5.0 0.4 1.6 -0.2 2.2 0.8
Back pain experienced in last month 0.9 1.3 3.1 -1.0 1.5 1.8 -0.5 0.1
Mineral and other dietary supplements 0.6 0.7 1.4 -1.2 0.8 0.3 -1.1 0.6
Breast cancer (self-reported) 0.8 1.0 3.7 -1.1 0.2 1.9 -0.0 0.4
Asthma (self-reported) 10.3 20.5 50.6 7.1 -6.1 -3.5 1.3 -1.1
Osteoporosis (self-reported) 0.6 0.7 3.3 1.8 0.2 -0.3 -0.2 -0.3
Osteoarthritis (self-reported) 0.4 0.5 1.1 0.0 0.3 1.0 1.0 -0.4
Medication: Aspirin 0.1 0.1 0.3 -0.4 -0.1 -0.6 -0.2 -0.2
Medication: Gliclazide 1.2 1.4 3.6 1.3 -0.3 1.9 1.2 -0.0
Illnesses of father: None of the above (group 1) 0.7 0.9 1.7 -1.3 0.7 1.3 -0.2 -0.7
Smoking status: Current 0.2 0.3 0.9 1.0 -0.2 0.6 0.3 0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.1 3.2 -0.5 1.3 0.4 1.8 0.0
Whole body water mass 0.2 0.9 3.4 -0.5 -0.7 1.8 -0.1 -0.4
Leg predicted mass (right) 0.1 0.6 1.4 -1.0 -0.5 1.2 -0.5 -0.5
Arm fat mass (left) 0.3 1.1 4.4 -2.1 0.0 0.3 -0.9 -0.3
Number of self-reported non-cancer illnesses 1.2 2.1 3.9 1.9 -0.4 -1.4 -2.0 0.9
Average weekly champagne plus white wine intake 0.3 0.4 1.6 0.3 0.1 -1.3 -0.5 0.4
Miserableness 0.2 0.4 0.8 0.8 -0.1 0.3 0.7 -0.9
Guilty feelings 0.3 0.5 1.3 1.2 -0.4 -0.4 0.2 1.0
Wears glasses or contact lenses 1.1 1.2 2.6 -0.1 1.6 1.0 0.6 1.4
Ever taken oral contraceptive pill 0.8 0.9 2.1 -1.5 0.1 -0.3 1.3 0.8
Hearing aid user 0.1 0.1 0.2 -0.3 0.4 -0.5 -0.2 0.0
Mother’s age at death 1.8 2.3 5.4 -2.3 1.5 0.2 -0.8 1.8
Financial situation satisfaction 1.1 1.3 3.7 0.7 -0.3 1.2 1.9 1.0
Tinnitus: Yes, now most or all of the time 0.9 1.0 3.2 1.8 -0.2 -0.7 0.4 -1.1
Commuting to job workplace: Public transport 1.7 2.0 3.0 -1.7 1.6 -1.7 0.1 1.4
Eye problems/disorders: Glaucoma 1.4 1.7 6.2 -0.7 0.3 1.2 2.5 0.6
Medication: Blood pressure 0.1 0.3 0.8 0.3 0.6 -0.2 0.9 0.0
Pain type(s) experienced in last month: Hip pain 0.2 0.3 0.9 0.2 0.3 -0.4 0.6 -0.9
Supplements: Fish oil (including cod liver oil) 0.9 1.2 3.3 1.3 -1.8 -0.1 0.7 -0.8
High cholesterol (Self-reported) 0.4 0.7 1.7 -1.1 -0.0 0.7 -0.2 1.3
Medication: Bendroflumethiazide 0.7 1.1 1.5 -0.5 1.2 -1.2 1.1 1.0
Medication: Paracetamol 0.3 0.5 2.2 -0.3 0.3 -0.4 0.1 1.5
Medication: Lisinopril 0.4 0.5 2.1 0.6 -0.4 -1.4 0.3 0.2
Medication: Atorvastatin 0.3 0.4 1.9 -1.4 0.2 -0.1 -0.2 -0.3
Illnesses of father: High blood pressure 2.4 3.0 8.6 -1.4 2.0 -0.5 -0.2 2.9
Alcohol drinker status: Never 1.9 2.3 4.6 -1.8 2.2 0.9 0.4 1.7
Ever smoked 0.8 1.4 2.1 0.6 -1.4 -1.4 -0.9 -1.4
Basal metabolic rate 0.2 0.8 2.8 -0.8 -0.6 1.7 -0.4 -0.5
Leg fat percentage (left) 0.2 0.8 2.0 -1.4 -0.2 0.7 -1.0 -0.7
Arm fat-free mass (left) 0.2 0.8 3.4 -0.7 -0.2 1.9 -0.1 -0.1
Number of operations (self-reported) 0.7 1.0 4.0 -0.3 0.7 0.4 -2.0 -0.7
Average weekly beer plus cider intake 0.7 0.9 2.9 1.2 -0.1 0.5 0.4 -1.7
Irritability 0.7 1.3 3.9 0.3 0.7 0.9 2.0 -1.0
Risk taking 1.0 1.5 3.1 -1.3 1.8 -0.2 -0.1 1.6
Ever had prostate specific antigen (PSA) test 1.0 1.2 3.4 0.1 -1.8 -1.5 -0.1 0.4
Fractured/broken bones in last 5 years 0.8 1.0 3.5 -1.0 1.9 0.6 -0.1 -0.2
Age started oral contraceptive pill 1.6 2.0 4.0 0.0 1.3 2.0 1.8 1.0
Diastolic blood pressure, automated reading 1.2 3.7 8.2 -2.9 2.2 0.2 0.3 2.3
Ever depressed for a whole week 1.0 1.3 4.7 -0.1 -0.8 -2.2 -0.6 -0.8
Unable to work because of sickness or disability 0.4 0.6 2.0 0.7 0.3 1.4 0.2 0.5
Commuting to job workplace: Cycle 0.2 0.2 0.7 0.8 -0.4 -0.0 -0.5 -0.0
Myopia 0.7 1.0 1.5 1.2 -1.2 -0.6 1.2 -0.5
Vascular/heart problems diagnosed by doctor 0.2 0.5 1.0 -0.3 -0.8 0.7 -1.0 0.4
Cholesterol lowering medication 1.7 2.5 3.7 -1.7 1.5 1.9 0.4 1.9
Medication: Omeprazole (e.g. Zanprol) 0.4 0.5 1.5 -0.7 0.2 0.5 -1.2 -0.4
Pain experienced in last month 0.9 1.6 3.5 1.2 -1.6 -1.9 -0.7 -0.3
Supplements: Calcium 2.3 2.5 7.5 1.3 1.7 0.2 2.7 -0.8
Basal cell carcinoma (self-reported) 0.7 0.8 1.8 0.8 0.1 0.3 1.2 1.3
Heart attack/myocardial infarction (self-reported) 1.2 1.6 5.5 0.6 0.7 -0.9 -0.8 -2.3
Deep venous thrombosis (DVT) (self-reported) 1.8 2.3 3.4 1.7 -1.8 -1.8 -1.3 0.6
Heart disease (siblings) 0.8 0.9 3.6 0.6 0.5 -0.7 0.3 -1.9
Alcohol drinker status: Previous 0.3 0.4 1.1 1.0 -0.2 -0.5 -0.0 -0.6
Pack years of smoking 1.2 1.8 3.2 -0.5 -0.0 -1.6 -1.8 1.7
Impedance of whole body 0.3 1.7 5.7 2.4 -0.8 -1.0 -0.9 0.5
Leg fat mass (left) 0.2 0.8 1.6 -1.2 -0.3 0.9 -1.1 -0.6
Arm predicted mass (left) 0.2 0.8 3.3 -0.5 -0.4 1.8 -0.0 -0.4