Hub : Genes

CAMK4

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.0498	0.0237	4.2e-03	0.013	0.025	0.020	0.026	0.010	4.5e-03	9.5e-05	4.9e-04	8.3e-05	9.1e-03
2	ROSMAP	Brain Pre-frontal Cortex	0.0979	0.0271	5.7e-06	0.034	0.035	0.029	0.036	0.039	2.9e-05	2.0e-05	1.2e-04	1.6e-05	7.8e-06
3	TCGA	Bladder Urothelial Carcinoma	0.0440	0.0230	8.4e-03	0.039	0.011	-0.003	NA	0.007	3.0e-04	3.6e-02	6.4e-01	NA	8.0e-02
4	TCGA	Pancreatic Adenocarcinoma	0.1560	0.0610	1.9e-03	-0.002	0.048	0.018	NA	0.013	4.1e-01	4.3e-03	5.5e-02	NA	8.6e-02
5	TCGA	Prostate Adenocarcinoma	0.1373	0.0426	2.1e-07	0.072	0.065	0.040	NA	0.067	5.5e-08	2.4e-07	4.4e-05	NA	1.5e-07

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	1.0	1.6	5.7	0.3	-0.3	-0.3	-1.4	-2.4
Bipolar Disorder or Schizophrenia	1.0	2.5	7.3	1.6	-1.4	0.6	0.5	-2.7
Depressed Affect (Nagel 2018)	1.4	2.9	10.7	1.4	1.0	0.9	3.3	-0.1
Depression (Nagel 2018)	1.0	1.6	2.6	-0.2	1.3	0.9	1.6	1.6
Intelligence (Savage-Jansen 2018)	0.9	2.7	7.0	0.1	-0.4	-2.1	1.4	2.6
Neuroticism (Nagel 2018)	1.3	3.1	10.5	2.0	0.3	0.8	3.2	-0.7
Schizophrenia (2018)	1.2	2.5	3.5	1.9	-1.6	0.9	1.8	-1.5
Schizophrenia vs Biploar Disorder	0.8	1.1	3.0	-0.1	0.6	0.1	1.7	1.4
Worry (Nagel 2018)	1.5	3.1	11.0	1.7	0.1	1.3	3.3	-0.1
Alzheimer’s Disease (in mother)	1.4	1.6	2.5	0.8	-1.0	-1.2	-1.6	-1.5
Alzheimer’s Disease (in father)	0.8	0.9	1.7	-1.3	0.9	-0.4	-1.3	0.2
Alzheimer’s Disease (including proxy)	0.2	0.2	0.6	0.3	-0.3	-0.8	-0.4	-0.5
Crohns Disease (2017)	0.1	0.2	0.7	0.2	0.0	0.3	0.2	-0.8
Irritable Bowel Disease (IBD)	0.5	1.1	3.2	1.8	-1.1	0.7	0.2	-0.8
Ulcerative Colitis (UC)	1.0	1.9	5.2	2.3	-1.4	1.3	0.3	-0.8
Major Depression (MDD)	0.9	1.1	2.3	0.2	0.4	1.5	1.5	0.7
Reaction Time	0.9	1.7	4.1	-2.0	1.8	-0.0	-1.0	0.6
Verbal and Numeric Reasoning (VNR)	0.7	1.8	4.7	1.1	-0.8	-0.9	2.2	1.3
Breast Cancer	0.9	2.2	6.9	-1.4	1.3	0.6	-0.7	2.6
Ovarian Cancer	0.5	0.6	1.4	-0.0	0.5	1.2	1.1	-0.4
Prostate Cancer	0.5	0.7	1.7	0.1	-1.3	1.1	-0.4	-0.5
Age at First Birth	0.3	0.5	1.5	0.1	-1.2	0.7	0.4	0.3
Bipolar Disorder (2011)	1.6	1.5	4.8	1.5	-0.7	-0.3	0.3	-2.2
Body Mass Index (BMI) (2010)	1.5	2.0	5.1	-2.3	1.5	-0.8	0.4	1.5
Coronary Artery Disease (CAD)	0.4	0.5	1.1	0.7	-0.3	-1.1	-0.3	0.7
Crohns Disease (2012)	0.5	0.8	2.8	-0.6	-0.1	-0.8	-1.7	0.6
Mean Putamen Volume	0.3	0.3	1.1	-0.6	1.0	0.1	-0.5	0.0
Fasting Glucose	1.6	1.9	4.0	-0.6	1.3	1.8	-0.4	2.0
HbA1C	0.4	0.5	1.0	-1.0	1.0	-0.2	0.4	0.3
HDL Cholesterol	0.6	0.9	3.9	-0.9	-0.2	-2.0	-0.2	0.0
LDL Cholesterol	0.8	1.3	2.3	-0.3	1.2	0.7	1.4	1.5
Lupus	0.9	1.3	2.4	1.6	-1.0	1.2	1.1	-0.8
Neuroticism (2016)	0.8	1.1	4.0	2.0	-0.6	0.4	0.3	-1.0
Primary Biliary Cirrhosis	0.6	0.9	3.5	-1.9	0.1	-0.8	-0.5	0.5
Rheumatoid Arthritis	0.8	1.2	2.3	0.3	-0.6	1.1	1.3	-1.5
Schizophrenia (2014)	0.7	1.6	3.5	1.6	-1.9	0.4	1.2	-0.7
Triglycerides	0.1	0.2	0.8	-0.4	0.9	-0.2	-0.1	0.3
Type 2 Diabetes (T2D) (2012)	0.7	0.8	2.2	-1.5	0.9	0.5	-0.7	0.3
Ulcerative Colitis	0.4	0.6	1.5	1.2	-1.1	0.4	-0.5	0.1
Blood Eosinophil Count	7.8	59.9	134.6	8.8	-11.6	-8.5	-1.9	-3.4
Blood Platelet Count	0.1	1.1	2.9	1.7	-0.6	-0.4	1.3	0.5
Blood Red Count	0.2	2.3	5.9	-1.3	0.1	-0.1	-2.4	2.0
Blood White Count	0.3	1.9	4.6	2.1	-1.8	-1.1	-0.1	0.9
Heel T-Score	0.2	1.2	4.2	-2.0	1.2	-0.2	-0.1	-0.6
BMI	0.7	4.0	16.0	-4.0	0.9	-0.9	-1.6	0.0
Height	0.2	3.1	6.9	2.6	-2.0	2.0	-0.8	0.3
Waist Hip Ratio (WHR)	0.4	2.0	5.2	2.3	-1.5	-0.3	0.8	-1.4
Systolic Blood Pressure	0.1	0.5	0.9	-0.1	0.9	0.5	0.8	0.8
Smoking Status	0.2	0.4	1.0	1.0	-0.7	-0.3	0.5	0.3
Allergy or Eczema	19.1	50.3	108.2	10.4	-10.1	-6.4	0.7	-0.2
Cardiovascular Disease	0.0	0.1	0.3	-0.4	0.4	0.0	0.2	0.6
Hypothyroidism (self reported)	1.5	3.4	12.2	-1.2	-0.9	-1.5	-3.5	-0.6
Respiratory disease	7.9	17.6	46.6	6.8	-5.4	-3.5	0.4	-0.3
Type 2 Diabetes (T2D) (2018)	0.2	0.4	1.2	-0.7	-0.2	-0.3	0.1	1.1
Lung FEV1/FVC ratio	0.8	4.1	9.5	-1.3	0.2	-3.1	-2.3	-2.0
Lung FVC	0.2	1.1	2.3	-0.2	0.4	1.1	1.5	1.4
Neuroticism	0.9	2.1	5.7	1.9	0.8	0.8	2.4	-0.4
Chronotype (morning person)	3.0	6.9	13.5	-3.7	1.7	-1.7	-1.7	3.5
Hair Pigment	0.0	0.8	2.4	1.0	-0.9	-0.1	0.1	-1.5
Tanning	0.0	0.3	0.7	-0.0	0.8	0.6	0.6	-0.3
Hand grip strength (left)	0.3	0.9	2.2	0.3	-1.5	1.0	-0.6	-0.9
Number of treatments/medications taken	0.4	0.7	1.4	0.9	0.2	-1.2	-0.8	0.8
Average weekly spirits intake	1.7	2.1	9.0	-3.0	0.9	0.3	-0.2	0.7
Sensitivity / hurt feelings	1.0	1.7	3.0	0.7	1.7	1.6	1.4	-0.3
Frequency of depressed mood in last 2 weeks	0.8	1.2	4.0	0.9	0.7	0.3	2.0	0.7
Hearing difficulty/problems: Yes	1.0	1.5	6.4	-0.1	-0.8	-2.5	-0.0	-0.7
Relative age of first facial hair	0.4	0.7	2.1	0.3	-1.4	1.0	-0.6	-0.3
Other serious medical condition/disability diagnosed by doctor	1.6	2.1	5.0	-0.5	2.2	1.1	-0.3	1.9
Ever used hormone-replacement therapy (HRT)	1.3	1.7	3.7	-1.0	1.9	0.3	1.3	1.4
Ever had hysterectomy (womb removed)	1.6	1.8	3.8	1.2	0.5	1.8	2.0	0.2
Systolic blood pressure, automated reading	1.3	3.9	7.6	-2.1	2.4	0.6	1.1	2.8
Eye problems/disorders: Diabetes related eye disease	0.7	0.7	2.3	-0.2	0.1	-1.5	1.1	0.3
Angina	0.7	1.0	2.3	-0.0	-1.0	-0.9	-0.9	-1.5
Medication for hormone replacement therapy	0.8	0.9	2.0	-1.4	1.2	-0.1	0.3	1.1
Vitamin and mineral supplements	0.6	0.8	1.5	-1.1	0.5	0.9	-0.5	1.2
Supplements: Zinc	1.8	2.0	5.3	1.4	-0.3	-0.1	1.6	-2.3
Medication: Co-codamol	0.5	0.6	1.9	-0.5	-0.4	-1.4	-0.6	0.7
Medication: Metformin	0.2	0.2	0.4	-0.5	0.6	0.6	0.1	0.2
Diabetes (father)	1.1	1.4	4.6	0.3	-1.1	-2.1	-0.2	1.0
Diabetes (mother)	1.6	2.1	3.6	-1.9	1.9	1.7	0.3	0.6
Severe depression (siblings)	0.6	0.7	2.8	-0.1	1.7	0.8	0.5	0.0
Pack years adult smoking proportion	1.4	2.1	4.0	-0.6	0.0	-1.7	-2.0	1.8
Impedance of leg (right)	0.3	1.7	7.5	2.7	-0.6	0.0	-0.6	0.1
Leg fat-free mass (left)	0.1	0.7	1.3	-0.9	-0.5	1.2	-0.6	-0.7
Trunk fat percentage	0.2	0.7	1.7	-1.2	-0.1	-0.1	-1.3	-0.1
Hand grip strength (right)	0.2	0.5	1.4	-0.4	-0.9	1.2	-0.3	-0.4
Townsend deprivation index at recruitment	0.8	1.1	2.9	-0.9	1.7	0.6	-1.1	-0.2
Current tobacco smoking	0.2	0.4	1.3	1.1	-0.3	0.5	-0.1	0.4
Average weekly fortified wine intake	0.6	0.7	2.0	-0.8	-0.1	0.6	-1.4	-0.7
Maternal smoking around birth	0.6	0.9	1.9	-1.0	0.9	1.4	-0.9	0.3
Fed-up feelings	1.2	2.1	4.6	1.1	1.8	2.1	1.2	-0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	2.6	3.5	8.1	-1.3	2.8	1.4	1.3	2.0
Relative age voice broke	0.7	1.1	2.1	0.2	-0.9	0.7	-1.4	-1.5
Taking other prescription medications	1.5	2.3	6.8	2.6	-0.6	-1.4	-1.5	-0.1
Age when periods started (menarche)	3.1	7.4	13.2	-2.9	3.6	1.1	-2.8	2.5
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.6	0.3	-0.1	-0.2	0.5	0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	0.6	-0.5	-0.8	-0.0	0.8	-0.8
Tinnitus: Yes, but not now, but have in the past	1.4	1.4	3.6	-1.9	1.4	-0.6	-1.1	-0.4
Qualifications: CSEs or equivalent	0.9	1.2	2.7	1.6	-0.2	0.8	-0.1	-1.6
Serious illness, injury or assault to yourself	0.5	0.6	1.9	-0.2	1.4	0.3	-0.4	1.0
High blood pressure	0.2	0.6	1.5	0.1	1.2	-0.4	1.2	0.3
Hayfever, allergic rhinitis or eczema	19.8	43.1	87.6	9.2	-9.4	-6.5	0.4	-0.5
Multivitamins +/- minerals	0.6	0.8	3.2	0.5	-0.3	-1.8	-0.2	-0.6
Stomach or abdominal pain in last month	2.0	2.5	7.3	-0.8	1.7	0.4	-1.3	2.7
Supplements: Glucosamine	0.2	0.3	0.9	0.2	0.5	0.4	0.4	-0.9
Diverticular disease/diverticulitis (self-reported)	2.2	2.6	3.2	-1.7	1.6	1.5	1.5	1.8
Medication: Atenolol	0.2	0.3	1.1	0.1	0.5	-0.1	-1.1	-0.4
Medication: Levothyroxine sodium	0.9	1.5	3.9	-0.6	0.3	-1.3	-2.0	-1.3
Sitting height	0.1	0.6	0.8	0.5	-0.9	0.8	-0.8	0.8
Chronic bronchitis/emphysema (father)	0.2	0.3	0.8	0.3	-0.4	0.4	-0.9	-0.3
High blood pressure (mother)	1.3	1.8	3.5	-1.5	1.9	0.6	-1.5	0.8
Body mass index (BMI)	0.4	1.6	7.5	-2.7	0.6	0.2	-0.5	-0.3
Impedance of leg (left)	0.3	1.6	7.0	2.6	-0.8	-0.0	-0.5	0.5
Leg predicted mass (left)	0.1	0.7	1.4	-0.8	-0.5	1.2	-0.6	-0.8
Trunk fat mass	0.1	0.6	1.4	-1.2	-0.3	0.5	-1.2	-0.1
Waist circumference	0.1	0.3	0.7	-0.8	-0.6	0.4	0.3	-0.7
Number of incorrect matches in round	0.5	0.9	3.0	-0.1	-1.7	0.1	-0.1	1.2
Past tobacco smoking	0.5	0.9	1.6	-0.4	1.1	1.3	0.2	1.2
Alcohol usually taken with meals	1.0	1.6	3.1	-1.8	1.6	-0.9	-0.3	1.2
Nervous feelings	0.9	1.7	5.1	0.8	0.8	0.9	2.3	1.2
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	3.1	-0.2	1.8	0.2	0.6	1.0
Hearing difficulty/problems with background noise	0.7	1.2	1.8	-1.2	1.2	-1.3	-0.1	1.0
Hair/balding pattern: Pattern 2	0.3	0.3	1.4	0.3	-0.4	1.2	-0.2	0.3
Had menopause	1.4	1.8	5.0	-0.7	2.2	0.8	1.1	1.1
Had other major operations	1.3	1.5	4.6	-1.0	1.0	1.0	-2.2	0.3
Forced vital capacity (FVC)	0.2	0.7	2.8	0.1	-0.7	0.5	-0.3	1.7
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	1.8	-0.3	-0.7	0.2	1.1	-1.3
Ever unenthusiastic/disinterested for a whole week	1.0	1.3	3.2	-0.7	-0.2	-1.6	-1.8	-0.1
Qualifications: None of the above	0.5	1.1	5.3	0.1	-0.1	2.3	-0.2	-0.3
Financial difficulties in last 2 years	1.0	1.3	2.3	1.5	-1.5	0.2	1.0	-0.9
Mouth/teeth dental problems	0.5	0.7	3.3	0.0	-0.4	-0.3	-0.2	1.8
Heart attack	1.2	1.6	5.5	0.7	0.6	-1.1	-0.6	-2.3
Allergy	22.2	51.0	110.2	-9.6	10.5	7.2	0.0	0.6
Pain all over the body in last month	2.5	2.7	3.9	-2.0	1.7	1.7	-1.6	1.2
Diabetes (self-reported)	0.1	0.2	0.7	-0.4	0.3	0.3	0.9	0.2
Hayfever/allergic rhinitis (self-reported)	13.7	18.2	41.1	5.5	-6.4	-4.1	0.6	-1.5
Medication: Ramipril	0.6	0.8	1.4	1.2	1.1	-0.5	-0.6	0.9
Medication: Simvastatin	0.1	0.1	0.2	0.2	-0.5	0.4	-0.3	-0.1
Fluid intelligence score	1.0	2.1	4.2	1.6	-1.2	-0.5	2.0	1.5
Illnesses of siblings	1.5	2.1	8.5	0.8	-0.9	2.9	-0.7	0.2
Neuroticism score	1.1	2.3	8.1	0.9	1.4	0.6	2.8	0.7
Weight	0.2	0.8	2.2	-1.5	-0.2	1.1	-0.6	-0.3
Impedance of arm (right)	0.6	2.9	6.2	2.5	-1.2	-2.3	-1.3	-0.1
Arm fat percentage (right)	0.4	1.5	4.8	-2.2	0.3	-0.7	-1.3	-0.5
Trunk fat-free mass	0.2	0.9	3.9	-0.3	-0.6	2.0	0.3	-0.3
Hip circumference	0.4	1.9	8.4	-2.9	0.9	0.6	-0.1	0.3
Time employed in main current job	0.6	0.7	1.9	0.4	-0.0	-1.4	0.9	0.8
Alcohol intake versus 10 years previously	0.9	1.3	2.4	1.2	-0.7	1.6	1.4	0.2
Father’s age at death	2.2	2.9	12.9	-0.3	-0.2	0.5	1.1	3.6
Worrier / anxious feelings	0.8	1.5	3.6	1.0	-1.2	-0.3	1.9	-1.1
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	2.3	0.8	0.2	-0.0	-0.0	-1.5
Falls in the last year	1.1	1.5	4.8	-0.7	2.2	-0.3	-1.2	0.9
Hair/balding pattern: Pattern 3	0.5	0.7	1.7	1.3	-0.7	0.4	-0.1	-1.0
Number of live births	0.8	1.2	3.6	0.3	-1.0	1.0	-1.9	0.3
Forced expiratory volume in 1-second (FEV1)	0.1	0.4	0.7	-0.4	-0.6	-0.4	-0.8	0.6
Pulse rate	0.2	0.4	1.0	0.4	-1.0	0.7	0.3	0.2
Happiness	0.2	0.3	0.6	-0.0	-0.7	-0.8	0.0	0.5
Noisy workplace	1.2	1.5	3.7	-1.9	1.9	-0.3	0.3	-0.4
Qualifications: A levels/AS levels or equivalent	0.8	1.7	5.4	-0.2	-1.3	-2.3	-0.2	1.2
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.6	1.6	-1.0	0.2	-1.3	0.5	-0.6
Mouth/teeth dental problems: Dentures	0.5	0.9	1.9	-0.9	0.6	0.8	-0.8	-1.4
Asthma	10.7	21.2	48.6	7.0	-6.3	-3.9	1.0	-1.3
Medication: Ibuprofen (e.g. Nurofen)	1.5	1.9	7.1	0.7	0.1	2.7	0.8	1.0
Medication: Cholesterol lowering	0.6	0.9	3.0	0.8	-1.0	0.1	-0.1	-1.7
Depression (self-reported)	1.7	2.0	6.9	2.6	-0.5	1.3	1.0	0.0
Medication: Lansoprazole	2.7	3.1	12.0	1.8	-0.1	0.5	3.5	0.0
Prospective memory result	0.5	0.6	2.0	-1.4	-0.0	-0.8	-0.2	0.4
Lung cancer (father)	0.5	0.5	1.7	-0.1	1.3	0.8	0.6	0.3
Illnesses of mother	0.3	0.4	1.0	0.2	-0.7	0.2	1.0	-0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.0	0.1	0.5	-0.4	-0.7	-0.2	-0.0	0.0
Pulse wave Arterial Stiffness index	1.3	1.5	6.6	-2.6	0.3	-0.4	-0.8	-0.4
Impedance of arm (left)	0.3	1.3	3.0	1.7	-0.8	-1.2	-1.0	0.2
Arm fat mass (right)	0.2	0.9	3.5	-1.9	0.0	0.3	-1.0	-0.4
Trunk predicted mass	0.2	1.0	4.1	-0.3	-0.7	2.0	0.3	-0.3
Standing height	0.2	2.4	5.8	2.4	-1.6	1.8	-0.3	0.3
Length of working week for main job	0.8	0.8	2.9	0.1	-0.5	-1.0	-0.0	-1.7
Exposure to tobacco smoke at home	0.4	0.4	1.7	-0.6	-0.2	-0.0	-0.2	-1.3
Breastfed as a baby	0.2	0.3	0.7	-0.3	0.9	-0.2	0.6	0.4
Tense / ‘highly strung’	0.7	1.2	4.4	0.7	0.9	0.2	2.1	0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.0	2.6	1.6	-1.0	-0.4	1.1	0.5
Hair/balding pattern: Pattern 4	1.0	2.5	5.1	-2.2	2.3	-0.2	0.2	1.5
Birth weight of first child	0.3	0.5	1.1	0.8	-0.3	0.4	0.8	1.1
Peak expiratory flow (PEF)	1.8	4.2	11.9	1.1	-3.5	-2.1	-1.3	-1.3
Pulse wave reflection index	0.2	0.3	0.5	-0.7	0.2	-0.3	-0.5	-0.7
Ever highly irritable/argumentative for 2 days	0.9	1.0	2.3	0.6	0.9	1.5	0.6	1.1
Loud music exposure frequency	0.9	0.9	1.7	1.1	0.1	-1.3	-1.0	-0.8
Qualifications: O levels/GCSEs or equivalent	0.2	0.2	0.5	0.6	-0.4	-0.7	0.2	-0.2
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.2	0.6	-0.0	-0.8	1.1	-0.2
Blood clot in the leg (DVT)	1.5	1.9	3.0	1.1	-1.7	-1.7	-1.4	0.7
Medication: Paracetamol	0.5	0.8	2.7	-0.4	1.0	0.5	0.4	1.6
Headache pain in last month	0.8	1.4	2.8	-0.6	1.7	1.3	1.4	0.4
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	2.2	-1.5	0.4	1.1	-0.9	1.2
Glaucoma (self-reported)	1.6	1.9	5.7	-0.9	-0.1	1.5	2.4	0.7
Gout (self-reported)	0.5	0.7	1.4	0.9	0.1	0.5	1.2	0.9
Hypothyroidism/myxoedema (self-reported)	1.5	3.0	11.0	-1.1	-0.3	-1.2	-3.3	-1.2
Medication: Amlodipine	0.6	0.8	3.5	0.1	-0.3	-1.9	-0.3	0.7
Medication: Ventolin 100micrograms inhaler	2.7	3.4	8.8	3.0	-2.3	0.6	1.4	-0.8
Birth weight	0.3	0.7	2.8	1.7	-0.2	-0.2	0.1	-0.7
Chronic bronchitis/emphysema (mother)	0.2	0.3	0.6	0.3	-0.4	-0.7	-0.3	-0.7
High blood pressure (siblings)	1.6	2.4	11.0	-0.3	0.7	-3.3	0.3	0.4
Forced vital capacity (FVC), Best measure	0.2	0.7	1.7	0.3	-0.9	0.8	0.4	1.3
Body fat percentage	0.2	0.7	2.0	-1.4	-0.0	0.0	-1.3	-0.3
Leg fat percentage (right)	0.2	0.8	1.8	-1.4	-0.2	0.6	-1.0	-0.8
Arm fat-free mass (right)	0.2	1.3	5.6	-0.7	-0.5	2.4	-0.0	-0.1
Exposure to tobacco smoke outside home	1.0	1.3	2.5	-1.3	1.6	-0.0	1.3	0.7
Comparative body size at age 10	0.8	2.2	5.6	0.4	-0.1	2.4	2.2	-0.7
Number of full brothers	0.5	0.6	1.7	-1.3	-0.5	0.3	-0.9	0.6
Worry too long after embarrassment	0.7	1.2	4.8	0.1	-0.7	-2.2	0.7	0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.7	2.2	0.9	-0.3	0.7	1.5	-0.4
Wheeze or whistling in the chest in last year	3.6	6.4	15.6	4.0	-2.8	-2.7	0.8	-0.5
Number of children fathered	1.1	1.2	4.0	-0.3	0.4	2.0	0.9	-0.9
Reason for reducing amount of alcohol drunk: Health precaution	2.0	2.3	4.1	1.0	-2.0	-1.9	-0.4	-1.6
Age at first live birth	1.0	1.8	2.8	1.7	-1.4	-1.0	1.5	-1.0
Pulse wave peak to peak time	1.5	1.7	7.3	2.7	-0.3	0.6	0.9	0.3
Health satisfaction	0.2	0.2	0.6	-0.5	0.1	-0.3	0.7	-0.3
Shortness of breath walking on level ground	0.8	0.9	2.0	-0.4	1.0	0.7	0.9	-1.4
Qualifications: College or University degree	1.1	3.4	12.0	-0.5	-1.3	-3.5	0.5	1.7
Eye problems/disorders: None of the above	0.2	0.3	0.6	-0.2	0.8	-0.7	-0.4	0.4
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.6	-0.4	0.3	-0.1	0.9	1.3
Emphysema/chronic bronchitis	0.7	0.8	2.3	-0.2	0.1	-1.1	-1.5	-0.7
Medication for pain relief, constipation, heartburn	0.2	0.4	1.2	0.0	-0.4	-1.1	0.6	-0.6
Neck or shoulder pain in last month	0.3	0.5	2.2	0.1	0.0	-0.2	-0.4	-1.5
Medication: Blood pressure	1.1	2.0	4.7	2.2	-0.2	-1.5	1.3	-1.1
Angina (self-reported)	0.7	0.9	1.9	0.1	-1.0	-0.8	-1.1	-1.4
Migraine (self-reported)	0.1	0.2	0.5	0.7	-0.4	-0.1	-0.3	0.3
Medication: Ibuprofen	0.7	0.8	3.3	0.1	0.3	1.8	0.1	0.8
Medication: Allopurinol	0.1	0.2	0.5	0.2	-0.7	-0.3	0.2	0.5
Medication: Omeprazole	0.9	1.1	2.4	-1.0	0.5	1.1	-1.6	-0.6
Medication: Seretide 50 evohaler	2.9	3.3	6.1	1.6	-2.2	-2.5	-1.8	-0.2
Mean time to correctly identify matches	0.9	1.7	4.5	-1.6	2.1	0.8	-0.6	0.8
Heart disease (mother)	0.3	0.4	0.7	-0.8	0.2	-0.7	0.8	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.5	2.9	7.6	-2.5	0.6	-0.2	-2.8	-0.6
Whole body fat mass	0.2	0.8	2.1	-1.4	-0.0	0.5	-1.3	-0.1
Leg fat mass (right)	0.2	0.8	1.5	-1.2	-0.4	0.8	-1.0	-0.7
Arm predicted mass (right)	0.3	1.5	7.0	-0.6	-0.5	2.6	-0.2	-0.2
Pulse rate, automated reading	0.3	0.9	2.8	0.7	-0.0	1.7	1.1	-0.2
Alcohol intake frequency.	0.7	1.6	2.5	-1.2	1.6	1.5	0.6	1.2
Comparative height size at age 10	0.2	0.9	1.9	1.3	-1.4	0.6	0.6	0.7
Number of full sisters	2.7	3.3	9.4	-2.4	3.1	0.7	-0.9	-0.4
Suffer from ‘nerves’	2.6	4.1	12.4	0.7	0.6	2.5	3.5	0.9
Overall health rating	0.4	0.9	3.9	0.1	2.0	0.2	0.5	-0.3
Chest pain or discomfort	0.2	0.2	0.8	-0.1	-0.1	-0.9	-0.6	-0.2
Had major operations	1.0	1.2	3.1	-0.8	-0.7	-1.3	-0.4	-1.8
Age at last live birth	0.4	0.6	1.0	1.0	-0.5	0.5	0.9	-0.8
Family relationship satisfaction	0.1	0.2	0.3	-0.5	-0.4	0.4	0.1	-0.5
Leg pain on walking	1.3	1.6	4.3	-1.2	2.1	-0.0	-0.2	1.5
Qualifications: NVQ or HND or HNC or equivalent	0.8	1.0	3.6	0.2	0.9	-0.4	0.7	-1.9
Commuting to job workplace: Car/motor vehicle	1.5	1.7	2.4	1.5	-1.4	1.5	0.5	-1.3
Illness, injury, bereavement, stress in last 2 years	0.5	0.7	2.6	0.3	-0.3	0.7	-1.6	0.2
Medication: Aspirin	0.1	0.1	0.2	-0.4	0.2	-0.4	-0.1	-0.5
Supplements: Vitamin C	1.1	1.3	2.2	1.5	0.5	1.3	1.2	-1.0
Knee pain experienced in last month	2.1	3.3	7.0	-1.0	2.0	2.1	2.6	0.5
Hypertension (Self-reported)	0.3	0.8	2.3	-0.2	1.5	-0.4	1.2	0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.0	0.0	0.2	-0.1	0.0	-0.2	-0.4	0.0
Illnesses of father: Heart disease	0.4	0.5	1.4	0.7	-0.3	-0.7	1.2	-0.4
Illnesses of siblings: Diabetes	0.3	0.4	1.6	-0.2	0.5	0.2	1.3	-0.2
Smoking status: Previous	0.5	0.7	1.6	0.3	-0.6	-1.3	-0.1	-1.2
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	3.4	0.8	0.5	1.9	0.1	-0.1
Whole body fat-free mass	0.1	0.8	3.3	-0.4	-0.6	1.8	-0.2	-0.4
Leg fat-free mass (right)	0.1	0.6	1.3	-0.9	-0.5	1.1	-0.5	-0.5
Arm fat percentage (left)	0.4	1.5	6.0	-2.4	0.1	-0.3	-1.2	-0.3
Average weekly red wine intake	1.0	1.5	2.2	-1.5	0.3	-1.3	-1.4	1.2
Handedness (chirality/laterality): Left-handed	1.5	1.8	4.8	1.9	-2.2	-0.2	-0.3	-0.7
Mood swings	1.2	2.2	8.7	1.3	0.5	0.8	3.0	0.1
Loneliness, isolation	0.9	1.2	3.5	0.9	0.5	0.6	1.9	1.2
Long-standing illness, disability or infirmity	1.9	3.0	10.3	-1.2	3.2	-1.3	-1.1	0.6
Ever had bowel cancer screening	0.6	0.7	1.9	-1.2	0.5	0.2	0.3	1.4
Diabetes diagnosed by doctor	0.2	0.3	0.7	-0.8	0.5	0.1	0.5	0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.8	2.3	-1.1	-0.1	1.5	-0.8	0.5
Friendships satisfaction	0.1	0.2	0.6	-0.3	-0.0	-0.1	0.8	-0.5
Qualifications: nursing, teaching	0.4	0.7	2.1	-0.3	1.0	-1.4	0.3	0.3
Commuting to job workplace: Walk	1.2	1.3	2.1	-1.0	1.5	-0.8	-0.8	1.5
Eye problems/disorders: Cataract	0.7	0.8	2.2	1.0	-1.5	0.5	-0.3	-0.5
Mouth/teeth dental problems: Mouth ulcers	1.4	2.2	5.2	1.9	-1.3	0.1	0.7	-2.3
Medication for cholesterol	1.1	1.7	3.4	1.4	-1.8	-0.4	-0.9	-1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.4	1.7	5.0	0.4	1.6	-0.2	2.2	0.8
Back pain experienced in last month	0.9	1.3	3.1	-1.0	1.5	1.8	-0.5	0.1
Mineral and other dietary supplements	0.6	0.7	1.4	-1.2	0.8	0.3	-1.1	0.6
Breast cancer (self-reported)	0.8	1.0	3.7	-1.1	0.2	1.9	-0.0	0.4
Asthma (self-reported)	10.3	20.5	50.6	7.1	-6.1	-3.5	1.3	-1.1
Osteoporosis (self-reported)	0.6	0.7	3.3	1.8	0.2	-0.3	-0.2	-0.3
Osteoarthritis (self-reported)	0.4	0.5	1.1	0.0	0.3	1.0	1.0	-0.4
Medication: Aspirin	0.1	0.1	0.3	-0.4	-0.1	-0.6	-0.2	-0.2
Medication: Gliclazide	1.2	1.4	3.6	1.3	-0.3	1.9	1.2	-0.0
Illnesses of father: None of the above (group 1)	0.7	0.9	1.7	-1.3	0.7	1.3	-0.2	-0.7
Smoking status: Current	0.2	0.3	0.9	1.0	-0.2	0.6	0.3	0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	3.2	-0.5	1.3	0.4	1.8	0.0
Whole body water mass	0.2	0.9	3.4	-0.5	-0.7	1.8	-0.1	-0.4
Leg predicted mass (right)	0.1	0.6	1.4	-1.0	-0.5	1.2	-0.5	-0.5
Arm fat mass (left)	0.3	1.1	4.4	-2.1	0.0	0.3	-0.9	-0.3
Number of self-reported non-cancer illnesses	1.2	2.1	3.9	1.9	-0.4	-1.4	-2.0	0.9
Average weekly champagne plus white wine intake	0.3	0.4	1.6	0.3	0.1	-1.3	-0.5	0.4
Miserableness	0.2	0.4	0.8	0.8	-0.1	0.3	0.7	-0.9
Guilty feelings	0.3	0.5	1.3	1.2	-0.4	-0.4	0.2	1.0
Wears glasses or contact lenses	1.1	1.2	2.6	-0.1	1.6	1.0	0.6	1.4
Ever taken oral contraceptive pill	0.8	0.9	2.1	-1.5	0.1	-0.3	1.3	0.8
Hearing aid user	0.1	0.1	0.2	-0.3	0.4	-0.5	-0.2	0.0
Mother’s age at death	1.8	2.3	5.4	-2.3	1.5	0.2	-0.8	1.8
Financial situation satisfaction	1.1	1.3	3.7	0.7	-0.3	1.2	1.9	1.0
Tinnitus: Yes, now most or all of the time	0.9	1.0	3.2	1.8	-0.2	-0.7	0.4	-1.1
Commuting to job workplace: Public transport	1.7	2.0	3.0	-1.7	1.6	-1.7	0.1	1.4
Eye problems/disorders: Glaucoma	1.4	1.7	6.2	-0.7	0.3	1.2	2.5	0.6
Medication: Blood pressure	0.1	0.3	0.8	0.3	0.6	-0.2	0.9	0.0
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.9	0.2	0.3	-0.4	0.6	-0.9
Supplements: Fish oil (including cod liver oil)	0.9	1.2	3.3	1.3	-1.8	-0.1	0.7	-0.8
High cholesterol (Self-reported)	0.4	0.7	1.7	-1.1	-0.0	0.7	-0.2	1.3
Medication: Bendroflumethiazide	0.7	1.1	1.5	-0.5	1.2	-1.2	1.1	1.0
Medication: Paracetamol	0.3	0.5	2.2	-0.3	0.3	-0.4	0.1	1.5
Medication: Lisinopril	0.4	0.5	2.1	0.6	-0.4	-1.4	0.3	0.2
Medication: Atorvastatin	0.3	0.4	1.9	-1.4	0.2	-0.1	-0.2	-0.3
Illnesses of father: High blood pressure	2.4	3.0	8.6	-1.4	2.0	-0.5	-0.2	2.9
Alcohol drinker status: Never	1.9	2.3	4.6	-1.8	2.2	0.9	0.4	1.7
Ever smoked	0.8	1.4	2.1	0.6	-1.4	-1.4	-0.9	-1.4
Basal metabolic rate	0.2	0.8	2.8	-0.8	-0.6	1.7	-0.4	-0.5
Leg fat percentage (left)	0.2	0.8	2.0	-1.4	-0.2	0.7	-1.0	-0.7
Arm fat-free mass (left)	0.2	0.8	3.4	-0.7	-0.2	1.9	-0.1	-0.1
Number of operations (self-reported)	0.7	1.0	4.0	-0.3	0.7	0.4	-2.0	-0.7
Average weekly beer plus cider intake	0.7	0.9	2.9	1.2	-0.1	0.5	0.4	-1.7
Irritability	0.7	1.3	3.9	0.3	0.7	0.9	2.0	-1.0
Risk taking	1.0	1.5	3.1	-1.3	1.8	-0.2	-0.1	1.6
Ever had prostate specific antigen (PSA) test	1.0	1.2	3.4	0.1	-1.8	-1.5	-0.1	0.4
Fractured/broken bones in last 5 years	0.8	1.0	3.5	-1.0	1.9	0.6	-0.1	-0.2
Age started oral contraceptive pill	1.6	2.0	4.0	0.0	1.3	2.0	1.8	1.0
Diastolic blood pressure, automated reading	1.2	3.7	8.2	-2.9	2.2	0.2	0.3	2.3
Ever depressed for a whole week	1.0	1.3	4.7	-0.1	-0.8	-2.2	-0.6	-0.8
Unable to work because of sickness or disability	0.4	0.6	2.0	0.7	0.3	1.4	0.2	0.5
Commuting to job workplace: Cycle	0.2	0.2	0.7	0.8	-0.4	-0.0	-0.5	-0.0
Myopia	0.7	1.0	1.5	1.2	-1.2	-0.6	1.2	-0.5
Vascular/heart problems diagnosed by doctor	0.2	0.5	1.0	-0.3	-0.8	0.7	-1.0	0.4
Cholesterol lowering medication	1.7	2.5	3.7	-1.7	1.5	1.9	0.4	1.9
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.5	-0.7	0.2	0.5	-1.2	-0.4
Pain experienced in last month	0.9	1.6	3.5	1.2	-1.6	-1.9	-0.7	-0.3
Supplements: Calcium	2.3	2.5	7.5	1.3	1.7	0.2	2.7	-0.8
Basal cell carcinoma (self-reported)	0.7	0.8	1.8	0.8	0.1	0.3	1.2	1.3
Heart attack/myocardial infarction (self-reported)	1.2	1.6	5.5	0.6	0.7	-0.9	-0.8	-2.3
Deep venous thrombosis (DVT) (self-reported)	1.8	2.3	3.4	1.7	-1.8	-1.8	-1.3	0.6
Heart disease (siblings)	0.8	0.9	3.6	0.6	0.5	-0.7	0.3	-1.9
Alcohol drinker status: Previous	0.3	0.4	1.1	1.0	-0.2	-0.5	-0.0	-0.6
Pack years of smoking	1.2	1.8	3.2	-0.5	-0.0	-1.6	-1.8	1.7
Impedance of whole body	0.3	1.7	5.7	2.4	-0.8	-1.0	-0.9	0.5
Leg fat mass (left)	0.2	0.8	1.6	-1.2	-0.3	0.9	-1.1	-0.6
Arm predicted mass (left)	0.2	0.8	3.3	-0.5	-0.4	1.8	-0.0	-0.4