[Hub]/) : Traits : High cholesterol (Self-reported) : ← →

chr6:159,820,779-161,571,560

Best TWAS P=5.5e-14 · Best GWAS P=1.04e-23 conditioned to 4.17e-13

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	SLC22A3	0.10	0.02	blup	582	0.05	4.4e-07	5.61	7.1	1.3e-12	0.09	0.09	0.91	FALSE
2	GTEx	Adipose Visceral Omentum	SLC22A3	0.13	0.06	enet	7	0.09	1.3e-05	5.20	5.4	7.1e-08	0.00	0.97	0.00	FALSE
3	GTEx	Artery Tibial	RP11-288H12.3	0.17	0.01	lasso	8	0.06	2.3e-05	2.35	5.6	1.7e-08	0.14	0.23	0.05	FALSE
4	GTEx	Brain Caudate basal ganglia	SLC22A3	0.15	0.10	enet	39	0.11	5.6e-04	6.43	5.5	3.3e-08	-0.04	0.40	0.03	FALSE
5	GTEx	Brain Frontal Cortex BA9	SLC22A3	0.26	0.08	lasso	6	0.05	1.5e-02	6.98	7.5	5.5e-14	0.00	0.34	0.05	TRUE
6	GTEx	Esophagus Mucosa	SLC22A3	0.19	0.08	enet	47	0.12	1.7e-08	-5.06	5.6	2.8e-08	0.03	0.99	0.00	FALSE
7	GTEx	Ovary	SLC22A3	0.33	0.29	lasso	6	0.23	2.8e-06	5.39	5.6	2.0e-08	-0.02	0.56	0.04	FALSE
8	GTEx	Skin Not Sun Exposed Suprapubic	SLC22A3	0.15	0.05	lasso	9	0.05	9.9e-04	4.57	6.9	5.1e-12	0.06	0.74	0.02	FALSE
9	GTEx	Skin Sun Exposed Lower leg	SLC22A3	0.29	0.14	lasso	10	0.20	3.7e-16	-5.25	6.3	2.8e-10	0.00	1.00	0.00	FALSE
10	GTEx	Thyroid	RP11-288H12.3	0.14	0.07	enet	10	0.08	8.3e-07	-4.16	6.4	1.6e-10	0.23	0.49	0.20	TRUE
11	METSIM	Adipose	SLC22A3	0.04	0.01	lasso	2	0.01	2.3e-03	-5.25	5.2	1.5e-07	0.02	0.19	0.14	TRUE
12	ROSMAP	Brain Pre-frontal Cortex	SLC22A3	0.14	0.20	lasso	10	0.19	2.4e-24	5.60	6.5	8.4e-11	0.04	1.00	0.00	FALSE
13	ROSMAP	Brain Pre-frontal Cortex	SLC22A1	0.04	0.00	bslmm	534	0.01	1.3e-02	0.79	-6.6	3.1e-11	-0.14	0.06	0.06	FALSE
14	The Cancer Genome Atlas	Breast Invasive Carcinoma	SLC22A1	0.04	0.01	enet	17	0.01	5.2e-04	3.60	-7.1	1.4e-12	-0.59	0.01	0.94	TRUE
15	The Cancer Genome Atlas	Colon Adenocarcinoma	SLC22A3	0.17	0.06	lasso	5	0.04	2.8e-03	6.58	-6.7	3.0e-11	-0.04	0.03	0.67	FALSE