Best TWAS P=3e-38 · Best GWAS P=4e-38 conditioned to 0.00164
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | ANKRD31 | 0.10 | 0.13 | lasso | 9 | 0.13 | 3.9e-15 | 7.4 | -6.7 | 2.1e-11 | -0.41 | 1.00 | 0.00 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | POC5 | 0.17 | 0.16 | lasso | 5 | 0.15 | 5.2e-18 | 6.8 | -6.8 | 1.2e-11 | -0.64 | 1.00 | 0.00 | FALSE |
| 3 | GTEx | Adrenal Gland | GCNT4 | 0.13 | 0.02 | lasso | 8 | 0.01 | 1.3e-01 | 4.0 | 5.8 | 4.8e-09 | 0.46 | 0.24 | 0.37 | FALSE |
| 4 | GTEx | Brain Cerebellar Hemisphere | POLK | 0.27 | 0.20 | lasso | 6 | 0.16 | 8.3e-05 | 9.3 | 8.7 | 2.9e-18 | 0.64 | 0.24 | 0.40 | FALSE |
| 5 | GTEx | Cells Transformed fibroblasts | POLK | 0.06 | 0.04 | lasso | 3 | 0.04 | 1.0e-03 | 5.5 | -6.1 | 1.3e-09 | -0.45 | 0.44 | 0.04 | FALSE |
| 6 | GTEx | Esophagus Mucosa | COL4A3BP | 0.09 | 0.06 | lasso | 5 | 0.05 | 4.2e-04 | 10.9 | -11.2 | 5.3e-29 | -0.69 | 0.28 | 0.66 | FALSE |
| 7 | GTEx | Spleen | POLK | 0.18 | -0.01 | lasso | 16 | 0.03 | 5.1e-02 | 10.4 | 9.6 | 1.0e-21 | 0.60 | 0.14 | 0.34 | FALSE |
| 8 | GTEx | Spleen | CTC-366B18.2 | 0.16 | 0.11 | lasso | 3 | 0.14 | 2.2e-04 | 4.4 | 5.5 | 3.2e-08 | 0.50 | 0.22 | 0.20 | FALSE |
| 9 | GTEx | Testis | GCNT4 | 0.42 | 0.35 | enet | 62 | 0.37 | 3.8e-17 | 7.4 | 6.4 | 1.4e-10 | 0.46 | 1.00 | 0.00 | FALSE |
| 10 | GTEx | Thyroid | CTC-366B18.2 | 0.06 | 0.03 | lasso | 9 | 0.02 | 6.2e-03 | 8.5 | 8.4 | 3.0e-17 | 0.57 | 0.26 | 0.29 | FALSE |
| 11 | METSIM | Adipose | POLK | 0.05 | 0.01 | enet | 16 | 0.03 | 4.3e-05 | 11.2 | 8.2 | 3.1e-16 | 0.68 | 0.02 | 0.98 | FALSE |
| 12 | ROSMAP | Brain Pre-frontal Cortex | POLK | 0.03 | 0.01 | lasso | 7 | 0.02 | 3.9e-03 | 7.7 | 8.5 | 1.9e-17 | 0.62 | 0.64 | 0.13 | FALSE |
| 13 | ROSMAP | Brain Pre-frontal Cortex | ANKDD1B | 0.07 | 0.00 | bslmm | 382 | 0.03 | 7.0e-05 | 3.3 | -6.5 | 9.0e-11 | -0.44 | 0.17 | 0.06 | FALSE |
| 14 | The Cancer Genome Atlas | Colon Adenocarcinoma | GCNT4 | 0.10 | 0.06 | enet | 6 | 0.05 | 8.7e-04 | 4.5 | -7.2 | 7.8e-13 | -0.43 | 0.02 | 0.90 | FALSE |
| 15 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | HMGCR | 0.04 | 0.02 | enet | 4 | 0.03 | 6.0e-03 | 12.9 | 12.9 | 3.0e-38 | 0.89 | 0.01 | 0.90 | TRUE |
| 16 | The Cancer Genome Atlas | Prostate Adenocarcinoma | POLK | 0.03 | 0.01 | blup | 53 | 0.01 | 1.6e-02 | 7.8 | -9.6 | 7.9e-22 | -0.63 | 0.34 | 0.39 | FALSE |