[Hub]/) : Traits : High cholesterol (Self-reported) : ← →

chr1:108,854,166-111,016,796

Best TWAS P=4.47e-80 · Best GWAS P=5.14e-80 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	CELSR2	0.03	0.00	lasso	10	0.01	1.5e-02	-13.72	11.8	6.4e-32	-0.58	0.10	0.32	FALSE
2	CommonMind	Brain Pre-frontal Cortex	PSRC1	0.20	0.04	lasso	8	0.13	4.8e-16	4.22	-12.1	8.4e-34	0.63	0.02	0.98	TRUE
3	GTEx	Brain Frontal Cortex BA9	PSRC1	0.27	-0.01	lasso	6	-0.01	6.8e-01	-2.83	-5.5	4.2e-08	0.29	0.04	0.23	FALSE
4	GTEx	Breast Mammary Tissue (Male)	AMIGO1	0.21	0.10	lasso	2	0.12	8.4e-04	-4.10	-5.2	2.2e-07	0.17	0.08	0.06	FALSE
5	GTEx	Cells Transformed fibroblasts	GPSM2	0.12	0.00	enet	24	0.01	5.6e-02	-1.28	7.0	1.8e-12	-0.39	0.06	0.37	TRUE
6	GTEx	Esophagus Mucosa	GPSM2	0.17	0.02	enet	34	0.07	1.5e-05	-2.52	-6.8	1.4e-11	0.22	0.50	0.09	TRUE
7	GTEx	Esophagus Mucosa	PSRC1	0.18	0.14	lasso	3	0.14	2.4e-09	-18.89	-18.6	1.4e-77	0.97	0.00	1.00	FALSE
8	GTEx	Esophagus Mucosa	SORT1	0.20	0.07	lasso	6	0.04	6.7e-04	0.45	-5.8	9.1e-09	0.29	0.18	0.26	FALSE
9	GTEx	Heart Atrial Appendage	RP5-1065J22.8	0.29	0.00	enet	29	0.11	1.5e-05	-0.27	-5.4	5.4e-08	0.41	0.06	0.16	FALSE
10	GTEx	Liver	SYPL2	0.34	0.27	lasso	5	0.30	4.6e-09	-2.29	-6.0	1.8e-09	0.38	0.80	0.13	FALSE
11	GTEx	Liver	CELSR2	0.39	0.36	lasso	1	0.35	1.0e-10	-18.89	-18.9	1.3e-79	1.00	0.00	1.00	TRUE
12	GTEx	Liver	ATXN7L2	0.39	0.04	lasso	12	0.21	1.3e-06	-1.57	-11.7	1.1e-31	0.69	0.07	0.81	TRUE
13	GTEx	Muscle Skeletal	CELSR2	0.41	0.31	lasso	4	0.30	2.4e-30	-18.89	-18.7	2.9e-78	1.00	0.00	1.00	FALSE
14	GTEx	Muscle Skeletal	AMIGO1	0.16	0.09	lasso	9	0.08	5.7e-08	-4.11	-5.6	2.2e-08	0.18	1.00	0.00	TRUE
15	GTEx	Nerve Tibial	SYPL2	0.09	0.00	enet	27	0.05	1.9e-04	-7.18	7.5	9.3e-14	-0.34	0.09	0.24	FALSE
16	GTEx	Pituitary	AC000032.2	0.36	-0.01	enet	1	0.05	1.8e-02	-6.96	-7.0	3.4e-12	0.45	0.05	0.12	FALSE
17	GTEx	Skin Sun Exposed Lower leg	CELSR2	0.18	0.05	lasso	6	0.06	8.1e-06	-15.41	-13.9	8.1e-44	0.75	0.01	0.98	FALSE
18	GTEx	Skin Sun Exposed Lower leg	RP5-1160K1.3	0.08	0.02	lasso	3	0.04	3.7e-04	-8.65	6.2	8.0e-10	-0.28	0.15	0.15	FALSE
19	GTEx	Small Intestine Terminal Ileum	RP4-735C1.4	0.74	0.31	enet	47	0.43	6.9e-11	2.47	-5.4	7.2e-08	0.26	0.39	0.18	FALSE
20	GTEx	Thyroid	PSRC1	0.29	0.25	lasso	3	0.25	3.6e-19	2.36	-6.0	1.7e-09	0.33	1.00	0.00	FALSE
21	GTEx	Whole Blood	PSRC1	0.14	0.04	lasso	3	0.03	6.9e-04	-18.93	-18.9	4.5e-80	0.99	0.00	1.00	FALSE
22	METSIM	Adipose	CELSR2	0.13	0.04	enet	28	0.06	5.0e-09	7.57	5.3	1.2e-07	-0.22	1.00	0.00	FALSE
23	ROSMAP	Brain Pre-frontal Cortex	GSTM1	0.51	0.05	blup	434	0.26	1.4e-33	0.03	5.6	1.7e-08	-0.16	1.00	0.00	TRUE
24	ROSMAP	Brain Pre-frontal Cortex	PSRC1	0.33	0.21	bslmm	430	0.26	1.2e-32	-18.89	-15.8	5.5e-56	0.82	0.00	1.00	FALSE
25	ROSMAP	Brain Pre-frontal Cortex	CELSR2	0.25	0.21	lasso	6	0.23	4.9e-29	-18.89	-18.5	9.5e-77	0.96	0.00	1.00	FALSE
26	ROSMAP	Brain Pre-frontal Cortex	AMIGO1	0.08	0.03	blup	404	0.03	8.7e-05	-4.60	-7.4	1.4e-13	0.25	0.93	0.01	FALSE
27	YFS	Blood	PSRC1	0.25	0.18	enet	32	0.24	1.6e-76	-18.89	-16.9	8.7e-64	0.87	0.00	1.00	FALSE
28	The Cancer Genome Atlas	Breast Invasive Carcinoma	PSRC1	0.03	0.00	blup	49	0.02	5.7e-05	-15.41	-15.1	8.7e-52	0.80	0.02	0.91	TRUE
29	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	PSRC1	0.14	0.04	enet	13	0.07	2.7e-04	-18.61	-13.4	3.9e-41	0.73	0.01	0.74	FALSE
30	The Cancer Genome Atlas	Colon Adenocarcinoma	CELSR2	0.12	0.00	enet	21	0.04	3.0e-03	-18.93	-12.8	2.6e-37	0.58	0.00	0.79	FALSE
31	The Cancer Genome Atlas	Colon Adenocarcinoma	PSRC1	0.07	0.06	lasso	1	0.04	1.8e-03	-15.41	-15.4	1.3e-53	0.75	0.01	0.83	FALSE
32	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PSRC1	0.14	0.05	enet	6	0.08	7.5e-09	2.36	-10.5	9.6e-26	0.50	0.16	0.60	FALSE
33	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PSRC1	0.12	0.11	lasso	4	0.09	4.5e-06	-18.18	-17.9	1.7e-71	0.92	0.01	0.99	FALSE
34	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	MYBPHL	0.09	0.07	blup	46	0.06	5.7e-04	1.03	-8.8	1.8e-18	0.55	0.03	0.50	FALSE
35	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	PSRC1	0.16	0.20	lasso	3	0.19	3.7e-09	-18.41	-18.4	2.1e-75	0.95	0.01	0.99	FALSE
36	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	SORT1	0.23	0.16	lasso	4	0.16	4.6e-08	-18.93	-18.1	3.3e-73	0.94	0.00	1.00	FALSE
37	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	AMIGO1	0.13	0.13	blup	46	0.12	1.7e-13	-4.29	-5.1	2.8e-07	0.18	0.03	0.85	FALSE
38	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	PSRC1	0.07	0.03	enet	8	0.05	3.4e-04	-18.61	-15.0	4.7e-51	0.77	0.01	0.92	FALSE
39	The Cancer Genome Atlas	Prostate Adenocarcinoma	PSRC1	0.18	0.10	enet	11	0.10	1.6e-10	2.36	-7.3	3.8e-13	0.38	1.00	0.00	FALSE
40	The Cancer Genome Atlas	Soft Tissue Sarcoma	PSRC1	0.09	0.00	blup	49	0.02	3.1e-02	-10.54	-12.6	2.8e-36	0.67	0.01	0.38	TRUE
41	The Cancer Genome Atlas	Stomach Adenocarcinoma	CELSR2	0.08	0.00	blup	62	0.02	8.1e-03	-1.75	-8.5	2.3e-17	0.50	0.01	0.26	FALSE
42	The Cancer Genome Atlas	Stomach Adenocarcinoma	PSRC1	0.12	0.03	enet	6	0.08	1.5e-06	-18.89	-13.5	1.9e-41	0.77	0.00	0.99	FALSE
43	The Cancer Genome Atlas	Stomach Adenocarcinoma	SORT1	0.04	0.01	blup	60	0.03	4.4e-03	-18.89	-11.4	3.6e-30	0.63	0.00	0.82	FALSE